Heavy Metal Or Aluminum Containing Patents (Class 544/225)
  • Patent number: 4495186
    Abstract: The invention relates to complex salts of N-cyclohexyl-piperazino-acetamides or propionamides with dihydroxy aluminum-.alpha.-hydroxy-carboxylates, a process for preparing them and the use thereof as antiulcer-antisecretive-buffering drugs.
    Type: Grant
    Filed: January 31, 1983
    Date of Patent: January 22, 1985
    Assignee: Camillo Corvi S.p.A.
    Inventor: Camillo C. Mora
  • Patent number: 4489002
    Abstract: Compounds of the general formula I ##STR1## where E is --CH.dbd. or --N.dbd., K is the radical of an amine or of a coupling component of the benzene, naphthalene, pyrazole, pyridine, pyrimidine, quinoline or isoquinoline series, or the radical of a 1,3-dicarbonyl compound which can be coupled, X is --O-- or --COO--, Y is --O--, --COO-- or --NH--, Z.sup.1 and Z.sup.2 independently of one another are unsubstituted or substituted alkyl or cycloalkyl, and one of them may furthermore be unsubstituted or substituted aryl, or Z.sup.1 and Z.sup.2 together with the nitrogen atom are a heterocyclic radical, and Z is unsubstituted or substituted C.sub.2 - or C.sub.3 -alkylene, from 1 to 4 sulfonic acid groups can be present and the rings A and B can be further substituted or can carry a fused benzene ring.The compounds of the present invention are suitable for dyeing or printing natural or synthetic N-containing materials, i.e., wool, leather or polyamide or polyurethane fibers, as wells as for coloring inks.
    Type: Grant
    Filed: June 4, 1982
    Date of Patent: December 18, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans Baumann, Klaus Grychtol
  • Patent number: 4478959
    Abstract: Amino and amido carboxylates of divalent tin, zinc, cobalt and nickel which are useful as catalysts for polyurethane formulations. Such compounds correspond to either of the formulae: ##STR1## wherein R.sub.1 and R.sub.2 are independently C.sub.1 -C.sub.20 alkyl, C.sub.6 -C.sub.20 cyclohydrocarbyl, C.sub.2 -C.sub.20 hydroxyalkyl or alkoxyalkyl, or R.sub.1 and R.sub.2 together with N form a nitrogen-containing heterocyclic ring of 5 or 6 atoms;R.sub.3 is a --CH.sub.2).sub.n group where n is an integer from 2 to 6 or a ##STR2## group where R.sub.4 is an alkyl, cycloalkyl or aryl group of up to 6 carbon atoms;A is ##STR3## wherein R.sub.5 and R.sub.6 are independently hydrogen, C.sub.1 -C.sub.4 alkyl or R.sub.5 and R.sub.6 together form part of a six-member cyclohydrocarbyl ring, andM is divalent tin, zinc, cobalt or nickel.
    Type: Grant
    Filed: September 29, 1983
    Date of Patent: October 23, 1984
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Ibrahim S. Bechara, Rocco L. Mascioli
  • Patent number: 4474952
    Abstract: Process for the preparation of 1:1 metal complexes of azines of the formula ##STR1## in which R.sub.1 is an H atom or an alkyl or aryl group, R.sub.2 is an isocyclic or heterocyclic radical with a hydroxyl or mercapto group adjacent to the azomethine group, Y' is the radical of a methylene-active compound or of an aryl-or heteroaryl-amine and the ring A can have substituents which do not confer solubility in water, which comprises heating a hydrazone of the formula ##STR2## with an isoindolinone of the formula ##STR3## in which R.sub.1, R.sub.2, A and Y' are as defined, in the presence of a metal donor, in a polar organic solvent.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: October 2, 1984
    Assignee: Ciba-Geigy Corporation
    Inventor: Abul Iqbal
  • Patent number: 4464373
    Abstract: Novel imidazoquinoxalines of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydroxy, alkoxy of 1 to 5 carbon atoms and cyclohexylcarbonyloxymethoxy, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkoxycarbonylvinyl of 4 to 7 carbon atoms, --COR, --CONH(CH.sub.2).sub.n --X and --A--(CH.sub.2).sub.m --Y, R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, alkenyl of 2 to 4 carbon atoms, alkoxy of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms, amino, --CF.sub.3, --CHCl.sub.2 --, phenyl, aralkyl of 7 to 10 carbon atoms, aralkoxy of 7 to 10 carbon atoms, n is 0 and X is phenyl or n is an integer from 1 to 5 and X is selected from the group consisting of ##STR2## R.sub.3 and R.sub.
    Type: Grant
    Filed: April 22, 1983
    Date of Patent: August 7, 1984
    Assignee: Roussel Uclaf
    Inventors: Alan C. Barnes, David P. Kay, Peter D. Kennewell, Frederick L. Parker, David A. Rowlands
  • Patent number: 4463175
    Abstract: A new composition of matter comprising molybdenum trioxide and heterocyclic nitrogen or oxygen Lewis bases. The molybdenum trioxide, upon reaction with Lewis base, forms a layered compound characterized in that the Lewis base is covalently bonded to molybdenum atoms in molybdenum oxide layers. The layered compound has the formula LMoO.sub.3 or L.sub.1/2 MoO.sub.3 where L is a Lewis base containing nitrogen or oxygen electron donors and selected from the group consisting of 5- and 6-membered heterocyclic amines, amine oxides, triorganophosphates, phosphine oxides and sulfoxides. L has the steric requirement such that its maximum cross-sectional area perpendicular to an axis running through the L-Mo covalent bond is less than about 30(.ANG.).sup.2.
    Type: Grant
    Filed: July 29, 1982
    Date of Patent: July 31, 1984
    Assignee: Exxon Research & Engineering Co.
    Inventors: Jack W. Johnson, Allan J. Jacobson
  • Patent number: 4459406
    Abstract: A new composition of matter comprising the reaction product of a mixed oxide having layers of corner linked octahedra and tetrahedra and a Lewis base. The reaction product forms a layered compound of the formula L.sub.x MOM'O.sub.4 where MOM'O.sub.4 is a mixed oxide selected from the group consisting of VOPO.sub.4, VOSO.sub.4, VOAsO.sub.4, VOMoO.sub.4, NbOPO.sub.4, NbOAsO.sub.4, TaOPO.sub.4 and MoOPO.sub.4, x is from about 0.1 to 1.0 and L is a Lewis base containing nitrogen or oxygen electron donor and is selected from the group consisting of 5-membered heterocyclic amines, 6-membered heterocyclic amines, amine oxides, triorganophosphates, phosphine oxides and sulfoxides. The layered compounds are characterized in that L is covalently bound to a metal atom in the MOM'O.sub.4 layer.
    Type: Grant
    Filed: July 29, 1982
    Date of Patent: July 10, 1984
    Assignee: Exxon Research and Engineering Co.
    Inventors: Jack W. Johnson, Allan J. Jacobson
  • Patent number: 4457927
    Abstract: Pyrido[2,1-b]quinazolinones of the formula ##STR1## wherein X is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl, carboxy, carboxy in the form of a salt thereof with a physiologically compatible base, carboxy esterified with a physiologically acceptable alcohol or carboxy amidated with a physiologically acceptable amine;R.sub.1 is hydrogen or methyl; andR.sub.2 through R.sub.5 are independently each hydrogen, halogen, alkyl of 1-4 carbon atoms, trifluoromethyl, carboxy, thiocyano, methylthio, methylsulfinyl, methylsulfonyl, methylsulfonimidoyl or methylsulfonamido with the proviso that two or three of the groups R.sub.2 through R.sub.5 are hydrogen; or a salt thereof with a physiologically acceptable acid or base;possess valuable pharmacological properties.
    Type: Grant
    Filed: December 22, 1982
    Date of Patent: July 3, 1984
    Assignee: Schering, Aktiengesellschaft
    Inventors: Helmut Biere, Joachim-Friedrich Kapp, Irmgard Bottcher
  • Patent number: 4454135
    Abstract: Novel tetraorganotin benzenesulfonamide compounds are described which possess insecticidal and arachnicidal activity. In addition, novel trifluoroacetate organotin benzenesulfonamide intermediates useful in the synthesis of these tetraorganotin benzenesulfonamide compounds are described.
    Type: Grant
    Filed: January 4, 1983
    Date of Patent: June 12, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Gerald E. Lepone
  • Patent number: 4447605
    Abstract: The present invention relates to a novel process for producing pyrimidine nucleosides by a reaction between bis(tri-lower alkylstannyl)-5-halogenouracil and 2-substituted tetrahydrofurane. The novel process of the present invention makes it possible to obtain, depending upon the manner of substitution of tetrahydrofurane residue on two nitrogen atoms N.sub.1 and N.sub.3 of 5-halogenouracil, N.sub.1 -mono-substituted compound, N.sub.3 -mono-substituted compound and N.sub.1,N-di-substituted compound among which the last can be converted by hydrolysis thereof into N.sub.1 -mono-substituted compound. The present invention further relates to novel N.sub.3 -mono-substituted compounds and N.sub.1,N.sub.3 -di-substituted compounds obtained by such process. The present invention still further relates to novel bis-(tri-lower alkylstannyl)-5-halogenouracil used in the present invention as a raw compound.
    Type: Grant
    Filed: July 28, 1981
    Date of Patent: May 8, 1984
    Assignee: Rikagaku Kenkyusho
    Inventors: Masanao Matsui, Tomoya Ogawa
  • Patent number: 4419351
    Abstract: A platinum-[2,4-dioxopyrimidine] complex and pharmaceutical composition suitable as an anti-tumor, anti-bacterial and anti-viral agent and process for the manufacture thereof comprising reacting a 2,4-dioxopyrimidine having the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are suitable substituents with cis-diaquodiamineplatinum (II).
    Type: Grant
    Filed: December 18, 1978
    Date of Patent: December 6, 1983
    Assignee: Research Corporation
    Inventors: Barnett Rosenberg, Loretta Van Camp, Robert G. Ficher, Samir Kansy, Henry J. Peresie, James P. Davidson
  • Patent number: 4416878
    Abstract: New [8-(dialkylamino alkoxy)-caffeine]-platinum complex compounds of the general formula ##STR1## are prepared from 8-(dialkylamino alkoxy)-caffeine and hexachloro platinic acid. The complex compounds are nonpoisonous, stable and infinitely durable. In pharmacological test series distinct cytostatic activity of the complex compounds is observed and they are suitable for use as active components in pharmaceutical products.
    Type: Grant
    Filed: December 4, 1981
    Date of Patent: November 22, 1983
    Inventor: Josef Klosa
  • Patent number: 4397700
    Abstract: Diferrocenyl piperazines represented by the formula: ##STR1## wherein Fc represents a ferrocene radial R represents alkylene radical hng from 1 to 7 carbon atoms, and x and y are 0 or 1 are disclosed as burning rate modifiers for ammonium perchlorate composite propellants. Coating ammonium perchlorate crystals with the differocenyl piperazines significantly decreases migration of the piperazines in the propellant.
    Type: Grant
    Filed: February 24, 1982
    Date of Patent: August 9, 1983
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Nancy C. Johnson, Carl Gotzmer, Mark Graff
  • Patent number: 4396617
    Abstract: The invention relates to novel 2-aryliminohexahydropyrimidines and imidazolidines, of the formula ##STR1## as well as to salts and complexes thereof, having fungicidal activity. These compounds are particularly active against rust of beans, brown rust of wheat and mildew on cereals. After having been processed into compositions, the compounds of the invention can successfully be used to prevent or control mould infections in agriculture and horticulture in a dosage of 200-1000 g of active substance per hectare.Very active fungicides are, for example, 2-(4-cyclohexyl-phenyl) iminohexahydropyrimidine and 2-(4-n-hexyl-phenyl) iminohexahydropyrimidine, as well as the sulphuric acid salts of these compounds and complexes with zinc salts.
    Type: Grant
    Filed: May 18, 1981
    Date of Patent: August 2, 1983
    Assignee: Duphar International B.V.
    Inventors: Hendrik Dolman, Johannes Kuipers
  • Patent number: 4388244
    Abstract: A petrolatum or hydrocarbon wax oxidate composition which comprises the reaction product of (a) a petrolatum or hydrocarbon wax oxidate, as described herein, or the metal salt thereof, with (b) a polyamine, as described herein, wherein the petrolatum or hydrocarbon wax oxidate composition has a very high viscosity, increased molecular weight and sinewy characteristics and is useful as a lubricant, grease, or protective coating.
    Type: Grant
    Filed: June 9, 1981
    Date of Patent: June 14, 1983
    Assignee: Ashland Oil, Inc.
    Inventor: Donald D. Carlos
  • Patent number: 4385174
    Abstract: The invention relates to a simplified process for the manufacture of 1:1 metal complexes of isoindoline azines of the formula ##STR1## wherein R is hydrogen, alkyl or aryl, Q contains an isocyclic or heterocyclic radical, acyl, carbamoyl or thiocarbamoyl, and Y is the radical of an active methylene group or aromatic amine, which comprises reacting a compound HQ or a hydrazone with an ortho ester or amidine in the presence of a metal donor at elevated temperature in a polar solvent. Pigments made by this process are lightfast and are useful in coloring plastics.
    Type: Grant
    Filed: March 9, 1981
    Date of Patent: May 24, 1983
    Assignee: Ciba-Geigy Corporation
    Inventors: Abul Iqbal, Paul Lienhard
  • Patent number: 4384117
    Abstract: The silver salt of metachloridine has been shown to have marked effectives against viruses, bacteria, fungi and protozoa. It is active against the organisms over a considerable concentration range in vitro, and has a noteworthy, high chemotherapeutic index when administered to animals by topical, oral or parenteral route. In addition to its effectiveness, silver metachloridine has been shown to be well tolerated at levels far above those required for therapeutic uses in animals.
    Type: Grant
    Filed: March 28, 1980
    Date of Patent: May 17, 1983
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Michael S. Wysor
  • Patent number: 4383021
    Abstract: Nickel complexes of diazabicyclooctane derivatives of one of the following formulae I and II are useful metallizing agents for the formation of metal complexed image dyes in image receiving elements for the dye diffusion transfer process ##STR1## In these formulae R.sup.1 represents an n-functional aliphatic hydrocarbon radical optionally containing carbocyclic or heterocyclic groups, carbonyl groups, sulphonyl groups and/or heteroatoms (O, S, N) as intermediate members;R.sup.2 and R.sup.3 represent hydrogen or alkyl;A.sup..crclbar. represents an anion; andn represents a number of from 1 to 5.
    Type: Grant
    Filed: February 10, 1982
    Date of Patent: May 10, 1983
    Assignee: Agfa-Gevaert Aktiengesellschaft
    Inventors: Peter Bergthaller, Guenter Helling, Jurgen Strauss
  • Patent number: 4374143
    Abstract: The invention relates to novel 2-aryliminohexahydropyrimidines and imidazolidines, of the formula ##STR1## as well as to salts and complexes thereof, having fungicidal activity. These compounds are particularly active against rust of beans, brown rust of wheat and mildew on cereals. After having been processed into compositions, the compounds of the invention can successfully be used to prevent or control mould infections in agriculture and horticulture in a dosage of 200-1000 g of active substance per hectare.Very active fungicides are, for example, 2-(4-cyclohexyl-phenyl) iminohexahydropyrimidine and 2-(4-n-hexyl-phenyl) iminohexahydropyrimidine, as well as the sulphuric acid salts of these compounds and complexes with zinc salts.
    Type: Grant
    Filed: May 18, 1981
    Date of Patent: February 15, 1983
    Assignee: Duphar International Research B.V.
    Inventors: Hendrik Dolman, Johannes Kuipers
  • Patent number: 4367333
    Abstract: 1:1 metal complexes of isoindolinazines of the formula ##STR1## in which the ring A can be further substituted, R is a hydrogen atom or an alkyl or aryl group, B is an isocyclic or heterocyclic aromatic radical, R.sub.1 is the OH or SH group and Y is a radical of the formula ##STR2## in which Z.sub.1 and Z.sub.2 are O or S atoms, n is the number 1 or 2, R.sub.2 ' is an alkyl, aryl or heteroaryl radical and R.sub.2 is an alkyl, cycloalkyl, aralkyl or aryl radical or a radical of the formula ##STR3## in which R.sub.3 is an alkylene or arylene group. The novel pigments color plastics and surface coatings in pure, intense orange to red shades with good fastness properties.
    Type: Grant
    Filed: March 9, 1981
    Date of Patent: January 4, 1983
    Assignee: Ciba-Geigy Corporation
    Inventor: Abul Iqbal
  • Patent number: 4366312
    Abstract: 1:1 metal complexes of azines of the formula ##STR1## in which the ring A can be further substituted, R is an H atom or an alkyl or aryl group, B is an isocyclic or heterocyclic aromatic radical or an alicyclic radical, R.sub.1 is the OH or SH group and Y is a radical of the formula ##STR2## in which Z is an O or S atom, n is the number 1 or 2 and R.sub.2 is an alkyl, aralkyl, cycloalkyl or aryl radical or an amino group which is unsubstituted or substituted by an alkyl, cycloalkyl, aralkyl or aryl radical.In plastics and surface coatings, the novel pigments give intense pure orange to violet colorations with good fastness properties.
    Type: Grant
    Filed: March 9, 1981
    Date of Patent: December 28, 1982
    Assignee: Ciba-Geigy Corporation
    Inventor: Abul Iqbal
  • Patent number: 4359576
    Abstract: Certain N-(2-pyrazinyl)-N-benzylcarbamates, having fungicidal and plant-growth regulating properties.
    Type: Grant
    Filed: June 2, 1981
    Date of Patent: November 16, 1982
    Assignee: Shell Oil Company
    Inventors: Pieter Ten Haken, Shirley B. Webb
  • Patent number: 4355161
    Abstract: A new composition of matter comprising molybdenum trioxide and heterocyclic nitrogen or oxygen Lewis bases. The molybdenum trioxide, upon reaction with Lewis base, forms a layered compound characterized in that the Lewis base is covalently bonded to molybdenum atoms in molybdenum oxide layers. The layered compound has the formula LMoO.sub.3 where L is a Lewis base containing nitrogen or oxygen electron donors and selected from the group consisting of 5- and 6-membered heterocyclic amines, amine oxides, triorganophosphates, phosphine oxides and sulfoxides. L has the steric requirement such that its cross-sectional area perpendicular to an axis running through the L-Mo covalent bond is less than about 30(A).sup.2.
    Type: Grant
    Filed: November 10, 1980
    Date of Patent: October 19, 1982
    Assignee: Exxon Research and Engineering Co.
    Inventors: Jack W. Johnson, Allan J. Jacobson
  • Patent number: 4355162
    Abstract: A new composition of matter comprising the reaction product of a mixed oxide having layers of corner linked octahedra and tetrahedra and a Lewis base. The reaction product forms a layered compound of the formula L.sub.x MOM'O.sub.4 where MOM'O.sub.4 is a mixed oxide selected from the group consisting of VOPO.sub.4, VOSO.sub.4, VOAsO.sub.4, VOMoO.sub.4, NbOPO.sub.4, NbOAsO.sub.4, TaOPO.sub.4 and MoOPO.sub.4, x is from about 0.1 to 1.0 and L is a Lewis base containing nitrogen or oxygen electron donor and is selected from the group consisting of 5-membered heterocyclic amines, 6-membered heterocyclic amines, amine oxides, triorganophosphates, phosphine oxides and sulfoxides. The layered compounds are characterized in that L is covalently bound to a metal atom in the MOM'O.sub.4 layer.
    Type: Grant
    Filed: November 10, 1980
    Date of Patent: October 19, 1982
    Assignee: Exxon Research and Engineering Co.
    Inventors: Jack W. Johnson, Allan J. Jacobson
  • Patent number: 4354024
    Abstract: A new composition of matter comprising layered compounds of tungsten trioxide and heterocyclic nitrogen or oxygen Lewis bases which have a unique layered structure. The layered compounds have the formula LWO.sub.3 where L is a Lewis base selected from the group consisting of 5-membered heterocyclic amines, 6-membered heterocyclic amines, amine oxides, triorganophosphates, phosphine oxides and sulfoxides, the layered compounds being characterized in that L is covalently bound to a tungsten atom in the tungsten oxide layer.
    Type: Grant
    Filed: November 10, 1980
    Date of Patent: October 12, 1982
    Assignee: Exxon Research and Engineering Company
    Inventors: Jack W. Johnson, Allan J. Jacobson
  • Patent number: 4349671
    Abstract: The invention relates to a process for the manufacture of 1:1 metal complexes of azines of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, an alkyl or aryl group, R.sub.2 is an isocyclic or heterocyclic radical containing a hydroxyl or mercapto group adjacent to the azomethine group, Y is the radical of a compound which contains active methylene groups, or of an aryl or heteroaryl amine, and the ring A can contain substituents that do not confer solubility in water, which process comprises reacting a compound of the formula ##STR2## wherein R.sub.3 is a hydrogen atom or an alkyl radical, R.sub.4 is an alkyl, aryl or heteroaryl radical or the radical of the formula ##STR3## or R.sub.3 and R.sub.4, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic ring, and Y has the given meaning, with a hydrazone of the formula ##STR4## in the presence of a transition metal donor and in a polar organic solvent, at temperatures above 100.degree. C.
    Type: Grant
    Filed: March 5, 1981
    Date of Patent: September 14, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Abul Iqbal, Paul Lienhard
  • Patent number: 4339448
    Abstract: New imidazole-copper complex compounds having a good fungicidal action, fungicides containing these compounds as active ingredients, processes for their manufacture, and their use for combating fungi.
    Type: Grant
    Filed: October 22, 1979
    Date of Patent: July 13, 1982
    Assignee: BASF Aktiengesellschaft
    Inventors: Toni Dockner, Anton Frank, Ernst-Heinrich Pommer
  • Patent number: 4331643
    Abstract: A process for preparing a ZSM-4 type crystalline zeolite material wherein 1,4-diazobicyclo (2.2.2) octane (DABCO), triethylenediamine (TED) is used as the source of an organic cation.
    Type: Grant
    Filed: December 15, 1980
    Date of Patent: May 25, 1982
    Assignee: Mobil Oil Corporation
    Inventors: Mae K. Rubin, Edward J. Rosinski
  • Patent number: 4327212
    Abstract: The isoindoline-azine nickel complex of the formula ##STR1## colors plastics, lacquers and printing inks in yellow shades of outstanding fastness properties.
    Type: Grant
    Filed: May 19, 1980
    Date of Patent: April 27, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Paul Lienhard, Francois L'Eplattenier
  • Patent number: 4325950
    Abstract: A platinum caffeine chloride anionic complex is formed by reacting K.sub.2 PtCl.sub.4 with caffeine in an aqueous solution at neutral pH under ambient conditions of temperature and pressure. This complex is particularly useful for cancer treatment.
    Type: Grant
    Filed: February 19, 1980
    Date of Patent: April 20, 1982
    Assignee: The Research Corporation of the University of Hawaii
    Inventor: Roger E. Cramer
  • Patent number: 4324895
    Abstract: The present invention relates to a novel process for producing pyrimidine nucleosides by a reaction between bis(tri-lower alkylstannyl)-5-halogenouracil and 2-substituted tetrahydrofurane. The novel process of the present invention makes it possible to obtain, depending upon the manner of substitution of tetrahydrofurane residue on two nitrogen atoms N.sub.1 and N.sub.3 of 5-halogenouracil, N.sub.1 -mono-substituted compound, N.sub.3 -mono-substituted compound and N.sub.1,N-di-substituted compound among which the last can be converted by hydrolysis thereof into N.sub.1 -mono-substituted compound. The present invention further relates to novel N.sub.3 -mono-substituted compounds and N.sub.1,N.sub.3 -di-substituted compounds obtained by such process. The present invention still further relates to novel bis-(tri-lower alkylstannyl)-5-halogenouracil used in the present invention as a raw compound.
    Type: Grant
    Filed: October 28, 1976
    Date of Patent: April 13, 1982
    Assignee: Rikagaku Kenkyusho
    Inventors: Masanao Matsui, Tomoya Ogawa
  • Patent number: 4321211
    Abstract: A carbonylation process for the preparation of carboxylic acid esters is described wherein carbon monoxide is contacted with at least one alcohol in the presence of a catalyst system having the general formula:B.sub.x Me[Me'(CO).sub.a (L).sub.b ].sub.2and a cocatalyst comprising halogen containing compounds in a cocatalyst to catalyst molar ratio ranging from about 1 to about 16, wherein B is a Lewis base capable of coordinating with a Group IIA metal; Me is a Group IIA metal, preferably magnesium, Me' is a transition metal selected from the group consisting of metals of Groups VIB, VIIB and VIII of the Periodic Table of the Elements; L is a uni- or polydentate ligand or hydrocarbon capable of coordinating with the transition metal; x is a positive integer ranging from 1 to 4; a is a positive integer ranging from 1 to 5 and b is an integer ranging from 0 to 4, with the proviso that the sum of a and b is 5 or less. A typical preferred catalyst system is represented by the general formula: (C.sub.4 H.sub.8 O).
    Type: Grant
    Filed: April 11, 1980
    Date of Patent: March 23, 1982
    Assignee: Exxon Research & Engineering Co.
    Inventor: Gary B. McVicker
  • Patent number: 4316853
    Abstract: Many varieties of harmful insects which attack useful plant crops can be controlled by treating the plants with compositions containing certain novel tetraorganotin compounds wherein three of the four hydrocarbon groups bonded to the tin atom are methyl and the remaining group is phenyl containing specified substituents or heterocyclic and is either bonded directly to the tin atom or separated from the tin atom by one methylene group. The present compounds exhibit unexpectedly superior insecticidal activity relative to prior art organotin compounds containing three methyl groups and a phenyl or an alkyl- substituted phenyl group bonded to the tin atom.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: February 23, 1982
    Assignee: M&T Chemicals Inc.
    Inventors: Melvin H. Gitlitz, John E. Engelhart, David A. Russo
  • Patent number: 4311843
    Abstract: Long chain di-n-alkyl esters of dicarboxypyrazinedicarboxylate from n-hexanol, n-octanol, n-decanol, n-dodecanol, and hexadecanol are prepared and characterized as liquid crystals, metals chelates, and surface active agents.
    Type: Grant
    Filed: February 20, 1981
    Date of Patent: January 19, 1982
    Inventor: Richard H. Wiley
  • Patent number: 4296030
    Abstract: This disclosure describes metal chelates of symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones useful for inhibiting the growth of tumors and as colorants or dyes.
    Type: Grant
    Filed: April 9, 1980
    Date of Patent: October 20, 1981
    Assignee: American Cyanamid Company
    Inventors: Stanley A. Lang, Jr., Keith C. Murdock
  • Patent number: 4294965
    Abstract: Certain sulfonamido pyridines, pyrimidines, benzothiazoles and oxazoles, metal complexes thereof and solutions of said compounds in essentially water-immiscible, liquid hydrocarbon solvents are disclosed. The sulfonamide compounds have the structural formula: ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification and claims thereof. Particular metal values are recovered from their aqueous solutions by using heterocyclic sulfonamide compounds dissolved in essentially water-immiscible, liquid hydrocarbon solvents. The extraction process generally comprises contacting the metal value containing aqueous solution with the solution of the sulfonamide compound in an essentially water-immiscible liquid hydrocarbon solvent and stripping the metal values from the loaded organic phase.
    Type: Grant
    Filed: January 31, 1980
    Date of Patent: October 13, 1981
    Assignee: Henkel Corporation
    Inventor: Michael J. Virnig
  • Patent number: 4294772
    Abstract: Tin-containing oxime derivatives of the formula ##STR1## wherein n is 0, 1 or 2,m is 0 or 1,Ar is an optionally substituted phenyl radical or an optionally substituted naphthyl radical, or when m is 0, Ar may also be an ester group,X is hydrogen, --CN, halogen, lower alkyl, lower alkanoyl, --COOH, a carboxylic acid ester radical, a carbamoyl radical andR.sub.8, R.sub.9 and R.sub.10, each independently of the other, are alkyl, aryl, aralkyl or C.sub.3 -C.sub.7 cycloalkyl, are suitable for protecting cultivated plants from the phytotoxic action of aggressive agrochemicals, in particular herbicides preferred are compounds of the above formula in whichAr is alkylphenyl, alkoxyphenyl, halophenyl, naphthyl or amido,X is cyano or a carboxylic acid ester radical, andR.sub.8, R.sub.9 and R.sub.10 are the same and are C.sub.1 -C.sub.4 alkyl, benzyl or phenyl.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: October 13, 1981
    Assignee: Ciba-Geigy Corporation
    Inventor: Henry Martin
  • Patent number: 4293549
    Abstract: This invention relates to new compounds, salts, complexes and acylated derivatives thereof, methods of producing said compounds, intermediates used in the method, pharmaceutical compositions containing the present compounds and methods of producing same, and a method of treating patients using the present compounds, having the general formula (I) ##STR1## in which R.sub.1 represents hydrogen, alkyl, alkoxy, hydroxy, halogen, trifluoromethyl, or phenyl; R.sub.2 represents hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, or hydroxy; R.sub.3 represents alkyl, cycloalkyl which can be further mono- or disubstituted with methyl or ethyl, phenyl or phenyl-alkyl, optionally being further substituted; and R.sub.
    Type: Grant
    Filed: October 27, 1978
    Date of Patent: October 6, 1981
    Assignee: Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktion-saktieselskab)
    Inventors: Schneur Rachlin, Edoardo Arrigoni-Martelli
  • Patent number: 4291033
    Abstract: Novel oxoimidazoquinoxalines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, chlorine and bromine, X is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms and cycloalkyl-alkyl of 4 to 6 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen alkyl of 1 to 5 carbon atoms, alkali metal, alkaline earth metal, aluminum, --NH.sub.4, organic amine and ##STR2## R.sub.4 and R.sub.5 are individually alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom form a saturated heterocycle of 4 to 6 carbon atoms optionally containing an oxygen atom or second nitrogen atom and n is a number from 1 to 5 and their non-toxic, pharmaceutically acceptable acid addition salts having antiallergic activity and their preparation.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: September 22, 1981
    Assignee: Roussel Uclaf
    Inventors: Alan C. Barnes, David P. Kay
  • Patent number: 4269834
    Abstract: A method of combatting mycoplasma infections by treatment with copper complexes of certain phenanthroline, isoquinoline and quinazoline derivatives. A number of the complexes and ligand compounds are novel, therapeutically useful substances. Processes for their preparation are described.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: May 26, 1981
    Inventor: Wijbe T. Nauta
  • Patent number: 4268668
    Abstract: An acid monomethine-metal complex dyestuff of the formula ##STR1## wherein M, Z, R, A, Y, n, a and b have the meaning given in the description.The acid metal complex dyestuffs of the formula I are valuable dyestuffs which are outstandingly suitable for dyeing and printing wool, silk and especially synthetic polyamides, such as NYLON and PERLON, in very clear shades ranging from yellow to blue, and are distinguished by high tinctorial strength, good build-up capacity and affinity and very good fastness characteristics, especially fastness to light.
    Type: Grant
    Filed: October 19, 1979
    Date of Patent: May 19, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Harnisch, Peter Rasche
  • Patent number: 4264494
    Abstract: Metal complex compounds which in the form of the free acids correspond to the formula I ##STR1## where A is an aliphatic, carbocyclic or heterocyclic radical,E is an aliphatic or carbocyclic radical,B is a cyano, acyl, substituted sulfonyl, carboxylic acid ester or carboxamide radical, orB and E together with the carbon atoms by which they are linked may be an alicyclic or heterocyclic radical,F is an aliphatic, carbocylic or heterocyclic radical,L is --O--, --COO--, ##STR2## n is 1, 2, 3 or 4, Y is .dbd.CH-- or .dbd.N-- andZ is ##STR3## or the radical of a coupling component, alkyl being of 1 to 4 carbon atoms, andR is hydrogen or unsubstituted or substituted alkyl, cycloalkyl, aryl or acyl and R.sup.1 and R.sup.2 are substituents conventionally present in dyes.The compounds of the formula I give fast dyeings on natural polyamides and synthetic nylons.
    Type: Grant
    Filed: August 2, 1978
    Date of Patent: April 28, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus Grychtol, Hans Baumann
  • Patent number: 4260757
    Abstract: Poly[di-1,2-(diazinylidene)-ethene-1,2-diols] having the structure:X--C.sub.4 H.sub.2 N.sub.2 --C(OH).dbd.C(OH)--C.sub.4 H.sub.2 N.sub.2 --C(OH) ].sub.n C(OH)--C.sub.4 H.sub.2 N.sub.2 --Yin which the C.sub.4 H.sub.2 N.sub.2 group is a diazinylidene diradical having each C(OH) group adjacent (ortho) to one but not two ring nitrogen atoms and not adjacent (ortho) to each other; X and Y are terminal formyl (CHO) groups or groups derived from them by oxidation; and n has a value of zero to seven--are prepared by a cyanide ion catalyzed condensation of pyrazine-2,5-dicarboxaldehyde, pyridazine-3,6-dicarboxaldehyde; or pyrimidine-4,6-dicarboxaldehyde as the only aldehydes which provide the requisite structures. The polymers form complexes with metal ions including manganese, which is insoluble, and vanadium, which is soluble.
    Type: Grant
    Filed: July 18, 1979
    Date of Patent: April 7, 1981
    Inventor: Richard H. Wiley
  • Patent number: 4256883
    Abstract: Stable biologically active aromatic prostacyclin analogues of the formula ##STR1## wherein X represents ##STR2## and R represents hydrogen, a pharmaceutically acceptable cation or a pharmaceutically acceptable lower alkyl group, are useful in the treatment of blood platelet aggregation and vascular constriction.
    Type: Grant
    Filed: March 14, 1979
    Date of Patent: March 17, 1981
    Assignee: Research Corporation
    Inventors: Kyriacos C. Nicolaou, William E. Barnette, Ronald L. Magolda
  • Patent number: 4254123
    Abstract: Novel imidazoquinoxalines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, --NH.sub.4, alkali metal, alkaline earth metal, magnesium, aluminum and non-toxic, pharmaceutically acceptable amines, X is selected from the group consisting of hydrogen, alkoxy of 1 to 5 carbon atoms and carbamoyl and Y and Z are individually selected from the group consisting of hydrogen and halogen and their non-toxic, pharmaceutically acceptable acid addition salts having anti-allergic activity and their preparation.
    Type: Grant
    Filed: July 30, 1979
    Date of Patent: March 3, 1981
    Assignee: Roussel Uclaf
    Inventors: Peter J. Ramm, Alan C. Barnes
  • Patent number: 4237292
    Abstract: Metal complexes of azomethines of the formula ##STR1## are useful for coloring plastics and lacquers in yellow to red shades of excellent fastness properties.
    Type: Grant
    Filed: October 26, 1978
    Date of Patent: December 2, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Francois L'Eplattenier, Andre Pugin, Jost von der Crone
  • Patent number: 4237286
    Abstract: Metal complexes of azomethines of the formula ##STR1## are useful for coloring plastics and lacquers in yellow to red shades of excellent fastness properties.
    Type: Grant
    Filed: October 26, 1978
    Date of Patent: December 2, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Francois L'Eplattenier, Andre Pugin, Jost von der Crone
  • Patent number: 4237293
    Abstract: Metal complexes of azomethines of the formula ##STR1## are useful for coloring plastics and lacquers in yellow to red shades of excellent fastness properties.
    Type: Grant
    Filed: October 26, 1978
    Date of Patent: December 2, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Francois L'Eplattenier, Andre Pugin, Jost von der Crone
  • Patent number: 4212810
    Abstract: Many varieties of harmful insects which attack useful plant crops can be controlled by treating the plants with compositions containing certain novel tetraorganotin compounds wherein three of the four hydrocarbon groups bonded to the tin atom are methyl and the remaining group is phenyl containing specified substituents or heterocyclic and is either bonded directly to the tin atom or separated from the tin atom by one methylene group. The present compounds exhibit unexpectedly superior insecticidal activity relative to prior art organotin compounds containing three methyl groups and a phenyl or an alkyl- substituted phenyl group bonded to the tin atom.
    Type: Grant
    Filed: December 21, 1978
    Date of Patent: July 15, 1980
    Assignee: M&T Chemicals Inc.
    Inventors: Melvin H. Gitlitz, John E. Engelhart, David A. Russo
  • Patent number: 4181517
    Abstract: 1,2,3-Thiadiazole-2-id-derivative of the formula ##STR1## in which R.sub.1 is hydrogen or alkyl which may be substituted in one or several places by oxygen or sulfur and wherein R.sub.1 has the meaning as given in the attached specification and wherein X is oxygen or sulfur and B is a univalent metal atom. The compounds have properties suited for controlling the natural growth and natural development of plants and in addition have a superior defoliating property.
    Type: Grant
    Filed: April 19, 1978
    Date of Patent: January 1, 1980
    Assignee: Schering Aktiengesellschaft
    Inventors: Hans-Rudolf Kruger, Reinhart Rusch, Friedrich Arndt