Heavy Metal Or Aluminum Containing Patents (Class 544/225)
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Patent number: 4495186Abstract: The invention relates to complex salts of N-cyclohexyl-piperazino-acetamides or propionamides with dihydroxy aluminum-.alpha.-hydroxy-carboxylates, a process for preparing them and the use thereof as antiulcer-antisecretive-buffering drugs.Type: GrantFiled: January 31, 1983Date of Patent: January 22, 1985Assignee: Camillo Corvi S.p.A.Inventor: Camillo C. Mora
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Patent number: 4489002Abstract: Compounds of the general formula I ##STR1## where E is --CH.dbd. or --N.dbd., K is the radical of an amine or of a coupling component of the benzene, naphthalene, pyrazole, pyridine, pyrimidine, quinoline or isoquinoline series, or the radical of a 1,3-dicarbonyl compound which can be coupled, X is --O-- or --COO--, Y is --O--, --COO-- or --NH--, Z.sup.1 and Z.sup.2 independently of one another are unsubstituted or substituted alkyl or cycloalkyl, and one of them may furthermore be unsubstituted or substituted aryl, or Z.sup.1 and Z.sup.2 together with the nitrogen atom are a heterocyclic radical, and Z is unsubstituted or substituted C.sub.2 - or C.sub.3 -alkylene, from 1 to 4 sulfonic acid groups can be present and the rings A and B can be further substituted or can carry a fused benzene ring.The compounds of the present invention are suitable for dyeing or printing natural or synthetic N-containing materials, i.e., wool, leather or polyamide or polyurethane fibers, as wells as for coloring inks.Type: GrantFiled: June 4, 1982Date of Patent: December 18, 1984Assignee: BASF AktiengesellschaftInventors: Hans Baumann, Klaus Grychtol
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Patent number: 4478959Abstract: Amino and amido carboxylates of divalent tin, zinc, cobalt and nickel which are useful as catalysts for polyurethane formulations. Such compounds correspond to either of the formulae: ##STR1## wherein R.sub.1 and R.sub.2 are independently C.sub.1 -C.sub.20 alkyl, C.sub.6 -C.sub.20 cyclohydrocarbyl, C.sub.2 -C.sub.20 hydroxyalkyl or alkoxyalkyl, or R.sub.1 and R.sub.2 together with N form a nitrogen-containing heterocyclic ring of 5 or 6 atoms;R.sub.3 is a --CH.sub.2).sub.n group where n is an integer from 2 to 6 or a ##STR2## group where R.sub.4 is an alkyl, cycloalkyl or aryl group of up to 6 carbon atoms;A is ##STR3## wherein R.sub.5 and R.sub.6 are independently hydrogen, C.sub.1 -C.sub.4 alkyl or R.sub.5 and R.sub.6 together form part of a six-member cyclohydrocarbyl ring, andM is divalent tin, zinc, cobalt or nickel.Type: GrantFiled: September 29, 1983Date of Patent: October 23, 1984Assignee: Air Products and Chemicals, Inc.Inventors: Ibrahim S. Bechara, Rocco L. Mascioli
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Patent number: 4474952Abstract: Process for the preparation of 1:1 metal complexes of azines of the formula ##STR1## in which R.sub.1 is an H atom or an alkyl or aryl group, R.sub.2 is an isocyclic or heterocyclic radical with a hydroxyl or mercapto group adjacent to the azomethine group, Y' is the radical of a methylene-active compound or of an aryl-or heteroaryl-amine and the ring A can have substituents which do not confer solubility in water, which comprises heating a hydrazone of the formula ##STR2## with an isoindolinone of the formula ##STR3## in which R.sub.1, R.sub.2, A and Y' are as defined, in the presence of a metal donor, in a polar organic solvent.Type: GrantFiled: September 13, 1982Date of Patent: October 2, 1984Assignee: Ciba-Geigy CorporationInventor: Abul Iqbal
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Patent number: 4464373Abstract: Novel imidazoquinoxalines of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydroxy, alkoxy of 1 to 5 carbon atoms and cyclohexylcarbonyloxymethoxy, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkoxycarbonylvinyl of 4 to 7 carbon atoms, --COR, --CONH(CH.sub.2).sub.n --X and --A--(CH.sub.2).sub.m --Y, R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, alkenyl of 2 to 4 carbon atoms, alkoxy of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms, amino, --CF.sub.3, --CHCl.sub.2 --, phenyl, aralkyl of 7 to 10 carbon atoms, aralkoxy of 7 to 10 carbon atoms, n is 0 and X is phenyl or n is an integer from 1 to 5 and X is selected from the group consisting of ##STR2## R.sub.3 and R.sub.Type: GrantFiled: April 22, 1983Date of Patent: August 7, 1984Assignee: Roussel UclafInventors: Alan C. Barnes, David P. Kay, Peter D. Kennewell, Frederick L. Parker, David A. Rowlands
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Patent number: 4463175Abstract: A new composition of matter comprising molybdenum trioxide and heterocyclic nitrogen or oxygen Lewis bases. The molybdenum trioxide, upon reaction with Lewis base, forms a layered compound characterized in that the Lewis base is covalently bonded to molybdenum atoms in molybdenum oxide layers. The layered compound has the formula LMoO.sub.3 or L.sub.1/2 MoO.sub.3 where L is a Lewis base containing nitrogen or oxygen electron donors and selected from the group consisting of 5- and 6-membered heterocyclic amines, amine oxides, triorganophosphates, phosphine oxides and sulfoxides. L has the steric requirement such that its maximum cross-sectional area perpendicular to an axis running through the L-Mo covalent bond is less than about 30(.ANG.).sup.2.Type: GrantFiled: July 29, 1982Date of Patent: July 31, 1984Assignee: Exxon Research & Engineering Co.Inventors: Jack W. Johnson, Allan J. Jacobson
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Patent number: 4459406Abstract: A new composition of matter comprising the reaction product of a mixed oxide having layers of corner linked octahedra and tetrahedra and a Lewis base. The reaction product forms a layered compound of the formula L.sub.x MOM'O.sub.4 where MOM'O.sub.4 is a mixed oxide selected from the group consisting of VOPO.sub.4, VOSO.sub.4, VOAsO.sub.4, VOMoO.sub.4, NbOPO.sub.4, NbOAsO.sub.4, TaOPO.sub.4 and MoOPO.sub.4, x is from about 0.1 to 1.0 and L is a Lewis base containing nitrogen or oxygen electron donor and is selected from the group consisting of 5-membered heterocyclic amines, 6-membered heterocyclic amines, amine oxides, triorganophosphates, phosphine oxides and sulfoxides. The layered compounds are characterized in that L is covalently bound to a metal atom in the MOM'O.sub.4 layer.Type: GrantFiled: July 29, 1982Date of Patent: July 10, 1984Assignee: Exxon Research and Engineering Co.Inventors: Jack W. Johnson, Allan J. Jacobson
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Patent number: 4457927Abstract: Pyrido[2,1-b]quinazolinones of the formula ##STR1## wherein X is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl, carboxy, carboxy in the form of a salt thereof with a physiologically compatible base, carboxy esterified with a physiologically acceptable alcohol or carboxy amidated with a physiologically acceptable amine;R.sub.1 is hydrogen or methyl; andR.sub.2 through R.sub.5 are independently each hydrogen, halogen, alkyl of 1-4 carbon atoms, trifluoromethyl, carboxy, thiocyano, methylthio, methylsulfinyl, methylsulfonyl, methylsulfonimidoyl or methylsulfonamido with the proviso that two or three of the groups R.sub.2 through R.sub.5 are hydrogen; or a salt thereof with a physiologically acceptable acid or base;possess valuable pharmacological properties.Type: GrantFiled: December 22, 1982Date of Patent: July 3, 1984Assignee: Schering, AktiengesellschaftInventors: Helmut Biere, Joachim-Friedrich Kapp, Irmgard Bottcher
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Patent number: 4454135Abstract: Novel tetraorganotin benzenesulfonamide compounds are described which possess insecticidal and arachnicidal activity. In addition, novel trifluoroacetate organotin benzenesulfonamide intermediates useful in the synthesis of these tetraorganotin benzenesulfonamide compounds are described.Type: GrantFiled: January 4, 1983Date of Patent: June 12, 1984Assignee: E. I. Du Pont de Nemours and CompanyInventor: Gerald E. Lepone
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Patent number: 4447605Abstract: The present invention relates to a novel process for producing pyrimidine nucleosides by a reaction between bis(tri-lower alkylstannyl)-5-halogenouracil and 2-substituted tetrahydrofurane. The novel process of the present invention makes it possible to obtain, depending upon the manner of substitution of tetrahydrofurane residue on two nitrogen atoms N.sub.1 and N.sub.3 of 5-halogenouracil, N.sub.1 -mono-substituted compound, N.sub.3 -mono-substituted compound and N.sub.1,N-di-substituted compound among which the last can be converted by hydrolysis thereof into N.sub.1 -mono-substituted compound. The present invention further relates to novel N.sub.3 -mono-substituted compounds and N.sub.1,N.sub.3 -di-substituted compounds obtained by such process. The present invention still further relates to novel bis-(tri-lower alkylstannyl)-5-halogenouracil used in the present invention as a raw compound.Type: GrantFiled: July 28, 1981Date of Patent: May 8, 1984Assignee: Rikagaku KenkyushoInventors: Masanao Matsui, Tomoya Ogawa
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Patent number: 4419351Abstract: A platinum-[2,4-dioxopyrimidine] complex and pharmaceutical composition suitable as an anti-tumor, anti-bacterial and anti-viral agent and process for the manufacture thereof comprising reacting a 2,4-dioxopyrimidine having the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are suitable substituents with cis-diaquodiamineplatinum (II).Type: GrantFiled: December 18, 1978Date of Patent: December 6, 1983Assignee: Research CorporationInventors: Barnett Rosenberg, Loretta Van Camp, Robert G. Ficher, Samir Kansy, Henry J. Peresie, James P. Davidson
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Patent number: 4416878Abstract: New [8-(dialkylamino alkoxy)-caffeine]-platinum complex compounds of the general formula ##STR1## are prepared from 8-(dialkylamino alkoxy)-caffeine and hexachloro platinic acid. The complex compounds are nonpoisonous, stable and infinitely durable. In pharmacological test series distinct cytostatic activity of the complex compounds is observed and they are suitable for use as active components in pharmaceutical products.Type: GrantFiled: December 4, 1981Date of Patent: November 22, 1983Inventor: Josef Klosa
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Patent number: 4397700Abstract: Diferrocenyl piperazines represented by the formula: ##STR1## wherein Fc represents a ferrocene radial R represents alkylene radical hng from 1 to 7 carbon atoms, and x and y are 0 or 1 are disclosed as burning rate modifiers for ammonium perchlorate composite propellants. Coating ammonium perchlorate crystals with the differocenyl piperazines significantly decreases migration of the piperazines in the propellant.Type: GrantFiled: February 24, 1982Date of Patent: August 9, 1983Assignee: The United States of America as represented by the Secretary of the NavyInventors: Nancy C. Johnson, Carl Gotzmer, Mark Graff
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Patent number: 4396617Abstract: The invention relates to novel 2-aryliminohexahydropyrimidines and imidazolidines, of the formula ##STR1## as well as to salts and complexes thereof, having fungicidal activity. These compounds are particularly active against rust of beans, brown rust of wheat and mildew on cereals. After having been processed into compositions, the compounds of the invention can successfully be used to prevent or control mould infections in agriculture and horticulture in a dosage of 200-1000 g of active substance per hectare.Very active fungicides are, for example, 2-(4-cyclohexyl-phenyl) iminohexahydropyrimidine and 2-(4-n-hexyl-phenyl) iminohexahydropyrimidine, as well as the sulphuric acid salts of these compounds and complexes with zinc salts.Type: GrantFiled: May 18, 1981Date of Patent: August 2, 1983Assignee: Duphar International B.V.Inventors: Hendrik Dolman, Johannes Kuipers
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Patent number: 4388244Abstract: A petrolatum or hydrocarbon wax oxidate composition which comprises the reaction product of (a) a petrolatum or hydrocarbon wax oxidate, as described herein, or the metal salt thereof, with (b) a polyamine, as described herein, wherein the petrolatum or hydrocarbon wax oxidate composition has a very high viscosity, increased molecular weight and sinewy characteristics and is useful as a lubricant, grease, or protective coating.Type: GrantFiled: June 9, 1981Date of Patent: June 14, 1983Assignee: Ashland Oil, Inc.Inventor: Donald D. Carlos
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Patent number: 4385174Abstract: The invention relates to a simplified process for the manufacture of 1:1 metal complexes of isoindoline azines of the formula ##STR1## wherein R is hydrogen, alkyl or aryl, Q contains an isocyclic or heterocyclic radical, acyl, carbamoyl or thiocarbamoyl, and Y is the radical of an active methylene group or aromatic amine, which comprises reacting a compound HQ or a hydrazone with an ortho ester or amidine in the presence of a metal donor at elevated temperature in a polar solvent. Pigments made by this process are lightfast and are useful in coloring plastics.Type: GrantFiled: March 9, 1981Date of Patent: May 24, 1983Assignee: Ciba-Geigy CorporationInventors: Abul Iqbal, Paul Lienhard
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Patent number: 4384117Abstract: The silver salt of metachloridine has been shown to have marked effectives against viruses, bacteria, fungi and protozoa. It is active against the organisms over a considerable concentration range in vitro, and has a noteworthy, high chemotherapeutic index when administered to animals by topical, oral or parenteral route. In addition to its effectiveness, silver metachloridine has been shown to be well tolerated at levels far above those required for therapeutic uses in animals.Type: GrantFiled: March 28, 1980Date of Patent: May 17, 1983Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Michael S. Wysor
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Patent number: 4383021Abstract: Nickel complexes of diazabicyclooctane derivatives of one of the following formulae I and II are useful metallizing agents for the formation of metal complexed image dyes in image receiving elements for the dye diffusion transfer process ##STR1## In these formulae R.sup.1 represents an n-functional aliphatic hydrocarbon radical optionally containing carbocyclic or heterocyclic groups, carbonyl groups, sulphonyl groups and/or heteroatoms (O, S, N) as intermediate members;R.sup.2 and R.sup.3 represent hydrogen or alkyl;A.sup..crclbar. represents an anion; andn represents a number of from 1 to 5.Type: GrantFiled: February 10, 1982Date of Patent: May 10, 1983Assignee: Agfa-Gevaert AktiengesellschaftInventors: Peter Bergthaller, Guenter Helling, Jurgen Strauss
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Patent number: 4374143Abstract: The invention relates to novel 2-aryliminohexahydropyrimidines and imidazolidines, of the formula ##STR1## as well as to salts and complexes thereof, having fungicidal activity. These compounds are particularly active against rust of beans, brown rust of wheat and mildew on cereals. After having been processed into compositions, the compounds of the invention can successfully be used to prevent or control mould infections in agriculture and horticulture in a dosage of 200-1000 g of active substance per hectare.Very active fungicides are, for example, 2-(4-cyclohexyl-phenyl) iminohexahydropyrimidine and 2-(4-n-hexyl-phenyl) iminohexahydropyrimidine, as well as the sulphuric acid salts of these compounds and complexes with zinc salts.Type: GrantFiled: May 18, 1981Date of Patent: February 15, 1983Assignee: Duphar International Research B.V.Inventors: Hendrik Dolman, Johannes Kuipers
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Patent number: 4367333Abstract: 1:1 metal complexes of isoindolinazines of the formula ##STR1## in which the ring A can be further substituted, R is a hydrogen atom or an alkyl or aryl group, B is an isocyclic or heterocyclic aromatic radical, R.sub.1 is the OH or SH group and Y is a radical of the formula ##STR2## in which Z.sub.1 and Z.sub.2 are O or S atoms, n is the number 1 or 2, R.sub.2 ' is an alkyl, aryl or heteroaryl radical and R.sub.2 is an alkyl, cycloalkyl, aralkyl or aryl radical or a radical of the formula ##STR3## in which R.sub.3 is an alkylene or arylene group. The novel pigments color plastics and surface coatings in pure, intense orange to red shades with good fastness properties.Type: GrantFiled: March 9, 1981Date of Patent: January 4, 1983Assignee: Ciba-Geigy CorporationInventor: Abul Iqbal
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Patent number: 4366312Abstract: 1:1 metal complexes of azines of the formula ##STR1## in which the ring A can be further substituted, R is an H atom or an alkyl or aryl group, B is an isocyclic or heterocyclic aromatic radical or an alicyclic radical, R.sub.1 is the OH or SH group and Y is a radical of the formula ##STR2## in which Z is an O or S atom, n is the number 1 or 2 and R.sub.2 is an alkyl, aralkyl, cycloalkyl or aryl radical or an amino group which is unsubstituted or substituted by an alkyl, cycloalkyl, aralkyl or aryl radical.In plastics and surface coatings, the novel pigments give intense pure orange to violet colorations with good fastness properties.Type: GrantFiled: March 9, 1981Date of Patent: December 28, 1982Assignee: Ciba-Geigy CorporationInventor: Abul Iqbal
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Patent number: 4359576Abstract: Certain N-(2-pyrazinyl)-N-benzylcarbamates, having fungicidal and plant-growth regulating properties.Type: GrantFiled: June 2, 1981Date of Patent: November 16, 1982Assignee: Shell Oil CompanyInventors: Pieter Ten Haken, Shirley B. Webb
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Patent number: 4355161Abstract: A new composition of matter comprising molybdenum trioxide and heterocyclic nitrogen or oxygen Lewis bases. The molybdenum trioxide, upon reaction with Lewis base, forms a layered compound characterized in that the Lewis base is covalently bonded to molybdenum atoms in molybdenum oxide layers. The layered compound has the formula LMoO.sub.3 where L is a Lewis base containing nitrogen or oxygen electron donors and selected from the group consisting of 5- and 6-membered heterocyclic amines, amine oxides, triorganophosphates, phosphine oxides and sulfoxides. L has the steric requirement such that its cross-sectional area perpendicular to an axis running through the L-Mo covalent bond is less than about 30(A).sup.2.Type: GrantFiled: November 10, 1980Date of Patent: October 19, 1982Assignee: Exxon Research and Engineering Co.Inventors: Jack W. Johnson, Allan J. Jacobson
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Patent number: 4355162Abstract: A new composition of matter comprising the reaction product of a mixed oxide having layers of corner linked octahedra and tetrahedra and a Lewis base. The reaction product forms a layered compound of the formula L.sub.x MOM'O.sub.4 where MOM'O.sub.4 is a mixed oxide selected from the group consisting of VOPO.sub.4, VOSO.sub.4, VOAsO.sub.4, VOMoO.sub.4, NbOPO.sub.4, NbOAsO.sub.4, TaOPO.sub.4 and MoOPO.sub.4, x is from about 0.1 to 1.0 and L is a Lewis base containing nitrogen or oxygen electron donor and is selected from the group consisting of 5-membered heterocyclic amines, 6-membered heterocyclic amines, amine oxides, triorganophosphates, phosphine oxides and sulfoxides. The layered compounds are characterized in that L is covalently bound to a metal atom in the MOM'O.sub.4 layer.Type: GrantFiled: November 10, 1980Date of Patent: October 19, 1982Assignee: Exxon Research and Engineering Co.Inventors: Jack W. Johnson, Allan J. Jacobson
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Patent number: 4354024Abstract: A new composition of matter comprising layered compounds of tungsten trioxide and heterocyclic nitrogen or oxygen Lewis bases which have a unique layered structure. The layered compounds have the formula LWO.sub.3 where L is a Lewis base selected from the group consisting of 5-membered heterocyclic amines, 6-membered heterocyclic amines, amine oxides, triorganophosphates, phosphine oxides and sulfoxides, the layered compounds being characterized in that L is covalently bound to a tungsten atom in the tungsten oxide layer.Type: GrantFiled: November 10, 1980Date of Patent: October 12, 1982Assignee: Exxon Research and Engineering CompanyInventors: Jack W. Johnson, Allan J. Jacobson
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Patent number: 4349671Abstract: The invention relates to a process for the manufacture of 1:1 metal complexes of azines of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, an alkyl or aryl group, R.sub.2 is an isocyclic or heterocyclic radical containing a hydroxyl or mercapto group adjacent to the azomethine group, Y is the radical of a compound which contains active methylene groups, or of an aryl or heteroaryl amine, and the ring A can contain substituents that do not confer solubility in water, which process comprises reacting a compound of the formula ##STR2## wherein R.sub.3 is a hydrogen atom or an alkyl radical, R.sub.4 is an alkyl, aryl or heteroaryl radical or the radical of the formula ##STR3## or R.sub.3 and R.sub.4, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic ring, and Y has the given meaning, with a hydrazone of the formula ##STR4## in the presence of a transition metal donor and in a polar organic solvent, at temperatures above 100.degree. C.Type: GrantFiled: March 5, 1981Date of Patent: September 14, 1982Assignee: Ciba-Geigy CorporationInventors: Abul Iqbal, Paul Lienhard
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Patent number: 4339448Abstract: New imidazole-copper complex compounds having a good fungicidal action, fungicides containing these compounds as active ingredients, processes for their manufacture, and their use for combating fungi.Type: GrantFiled: October 22, 1979Date of Patent: July 13, 1982Assignee: BASF AktiengesellschaftInventors: Toni Dockner, Anton Frank, Ernst-Heinrich Pommer
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Patent number: 4331643Abstract: A process for preparing a ZSM-4 type crystalline zeolite material wherein 1,4-diazobicyclo (2.2.2) octane (DABCO), triethylenediamine (TED) is used as the source of an organic cation.Type: GrantFiled: December 15, 1980Date of Patent: May 25, 1982Assignee: Mobil Oil CorporationInventors: Mae K. Rubin, Edward J. Rosinski
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Patent number: 4327212Abstract: The isoindoline-azine nickel complex of the formula ##STR1## colors plastics, lacquers and printing inks in yellow shades of outstanding fastness properties.Type: GrantFiled: May 19, 1980Date of Patent: April 27, 1982Assignee: Ciba-Geigy CorporationInventors: Paul Lienhard, Francois L'Eplattenier
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Patent number: 4325950Abstract: A platinum caffeine chloride anionic complex is formed by reacting K.sub.2 PtCl.sub.4 with caffeine in an aqueous solution at neutral pH under ambient conditions of temperature and pressure. This complex is particularly useful for cancer treatment.Type: GrantFiled: February 19, 1980Date of Patent: April 20, 1982Assignee: The Research Corporation of the University of HawaiiInventor: Roger E. Cramer
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Novel process for producing pyrimidine nucleosides and novel pyrimidine nucleosides obtained thereby
Patent number: 4324895Abstract: The present invention relates to a novel process for producing pyrimidine nucleosides by a reaction between bis(tri-lower alkylstannyl)-5-halogenouracil and 2-substituted tetrahydrofurane. The novel process of the present invention makes it possible to obtain, depending upon the manner of substitution of tetrahydrofurane residue on two nitrogen atoms N.sub.1 and N.sub.3 of 5-halogenouracil, N.sub.1 -mono-substituted compound, N.sub.3 -mono-substituted compound and N.sub.1,N-di-substituted compound among which the last can be converted by hydrolysis thereof into N.sub.1 -mono-substituted compound. The present invention further relates to novel N.sub.3 -mono-substituted compounds and N.sub.1,N.sub.3 -di-substituted compounds obtained by such process. The present invention still further relates to novel bis-(tri-lower alkylstannyl)-5-halogenouracil used in the present invention as a raw compound.Type: GrantFiled: October 28, 1976Date of Patent: April 13, 1982Assignee: Rikagaku KenkyushoInventors: Masanao Matsui, Tomoya Ogawa -
Patent number: 4321211Abstract: A carbonylation process for the preparation of carboxylic acid esters is described wherein carbon monoxide is contacted with at least one alcohol in the presence of a catalyst system having the general formula:B.sub.x Me[Me'(CO).sub.a (L).sub.b ].sub.2and a cocatalyst comprising halogen containing compounds in a cocatalyst to catalyst molar ratio ranging from about 1 to about 16, wherein B is a Lewis base capable of coordinating with a Group IIA metal; Me is a Group IIA metal, preferably magnesium, Me' is a transition metal selected from the group consisting of metals of Groups VIB, VIIB and VIII of the Periodic Table of the Elements; L is a uni- or polydentate ligand or hydrocarbon capable of coordinating with the transition metal; x is a positive integer ranging from 1 to 4; a is a positive integer ranging from 1 to 5 and b is an integer ranging from 0 to 4, with the proviso that the sum of a and b is 5 or less. A typical preferred catalyst system is represented by the general formula: (C.sub.4 H.sub.8 O).Type: GrantFiled: April 11, 1980Date of Patent: March 23, 1982Assignee: Exxon Research & Engineering Co.Inventor: Gary B. McVicker
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Patent number: 4316853Abstract: Many varieties of harmful insects which attack useful plant crops can be controlled by treating the plants with compositions containing certain novel tetraorganotin compounds wherein three of the four hydrocarbon groups bonded to the tin atom are methyl and the remaining group is phenyl containing specified substituents or heterocyclic and is either bonded directly to the tin atom or separated from the tin atom by one methylene group. The present compounds exhibit unexpectedly superior insecticidal activity relative to prior art organotin compounds containing three methyl groups and a phenyl or an alkyl- substituted phenyl group bonded to the tin atom.Type: GrantFiled: November 5, 1979Date of Patent: February 23, 1982Assignee: M&T Chemicals Inc.Inventors: Melvin H. Gitlitz, John E. Engelhart, David A. Russo
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Patent number: 4311843Abstract: Long chain di-n-alkyl esters of dicarboxypyrazinedicarboxylate from n-hexanol, n-octanol, n-decanol, n-dodecanol, and hexadecanol are prepared and characterized as liquid crystals, metals chelates, and surface active agents.Type: GrantFiled: February 20, 1981Date of Patent: January 19, 1982Inventor: Richard H. Wiley
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Patent number: 4296030Abstract: This disclosure describes metal chelates of symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones useful for inhibiting the growth of tumors and as colorants or dyes.Type: GrantFiled: April 9, 1980Date of Patent: October 20, 1981Assignee: American Cyanamid CompanyInventors: Stanley A. Lang, Jr., Keith C. Murdock
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Patent number: 4294965Abstract: Certain sulfonamido pyridines, pyrimidines, benzothiazoles and oxazoles, metal complexes thereof and solutions of said compounds in essentially water-immiscible, liquid hydrocarbon solvents are disclosed. The sulfonamide compounds have the structural formula: ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification and claims thereof. Particular metal values are recovered from their aqueous solutions by using heterocyclic sulfonamide compounds dissolved in essentially water-immiscible, liquid hydrocarbon solvents. The extraction process generally comprises contacting the metal value containing aqueous solution with the solution of the sulfonamide compound in an essentially water-immiscible liquid hydrocarbon solvent and stripping the metal values from the loaded organic phase.Type: GrantFiled: January 31, 1980Date of Patent: October 13, 1981Assignee: Henkel CorporationInventor: Michael J. Virnig
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Patent number: 4294772Abstract: Tin-containing oxime derivatives of the formula ##STR1## wherein n is 0, 1 or 2,m is 0 or 1,Ar is an optionally substituted phenyl radical or an optionally substituted naphthyl radical, or when m is 0, Ar may also be an ester group,X is hydrogen, --CN, halogen, lower alkyl, lower alkanoyl, --COOH, a carboxylic acid ester radical, a carbamoyl radical andR.sub.8, R.sub.9 and R.sub.10, each independently of the other, are alkyl, aryl, aralkyl or C.sub.3 -C.sub.7 cycloalkyl, are suitable for protecting cultivated plants from the phytotoxic action of aggressive agrochemicals, in particular herbicides preferred are compounds of the above formula in whichAr is alkylphenyl, alkoxyphenyl, halophenyl, naphthyl or amido,X is cyano or a carboxylic acid ester radical, andR.sub.8, R.sub.9 and R.sub.10 are the same and are C.sub.1 -C.sub.4 alkyl, benzyl or phenyl.Type: GrantFiled: August 20, 1979Date of Patent: October 13, 1981Assignee: Ciba-Geigy CorporationInventor: Henry Martin
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Patent number: 4293549Abstract: This invention relates to new compounds, salts, complexes and acylated derivatives thereof, methods of producing said compounds, intermediates used in the method, pharmaceutical compositions containing the present compounds and methods of producing same, and a method of treating patients using the present compounds, having the general formula (I) ##STR1## in which R.sub.1 represents hydrogen, alkyl, alkoxy, hydroxy, halogen, trifluoromethyl, or phenyl; R.sub.2 represents hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, or hydroxy; R.sub.3 represents alkyl, cycloalkyl which can be further mono- or disubstituted with methyl or ethyl, phenyl or phenyl-alkyl, optionally being further substituted; and R.sub.Type: GrantFiled: October 27, 1978Date of Patent: October 6, 1981Assignee: Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktion-saktieselskab)Inventors: Schneur Rachlin, Edoardo Arrigoni-Martelli
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Patent number: 4291033Abstract: Novel oxoimidazoquinoxalines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, chlorine and bromine, X is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms and cycloalkyl-alkyl of 4 to 6 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen alkyl of 1 to 5 carbon atoms, alkali metal, alkaline earth metal, aluminum, --NH.sub.4, organic amine and ##STR2## R.sub.4 and R.sub.5 are individually alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom form a saturated heterocycle of 4 to 6 carbon atoms optionally containing an oxygen atom or second nitrogen atom and n is a number from 1 to 5 and their non-toxic, pharmaceutically acceptable acid addition salts having antiallergic activity and their preparation.Type: GrantFiled: February 4, 1980Date of Patent: September 22, 1981Assignee: Roussel UclafInventors: Alan C. Barnes, David P. Kay
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Patent number: 4269834Abstract: A method of combatting mycoplasma infections by treatment with copper complexes of certain phenanthroline, isoquinoline and quinazoline derivatives. A number of the complexes and ligand compounds are novel, therapeutically useful substances. Processes for their preparation are described.Type: GrantFiled: June 19, 1978Date of Patent: May 26, 1981Inventor: Wijbe T. Nauta
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Patent number: 4268668Abstract: An acid monomethine-metal complex dyestuff of the formula ##STR1## wherein M, Z, R, A, Y, n, a and b have the meaning given in the description.The acid metal complex dyestuffs of the formula I are valuable dyestuffs which are outstandingly suitable for dyeing and printing wool, silk and especially synthetic polyamides, such as NYLON and PERLON, in very clear shades ranging from yellow to blue, and are distinguished by high tinctorial strength, good build-up capacity and affinity and very good fastness characteristics, especially fastness to light.Type: GrantFiled: October 19, 1979Date of Patent: May 19, 1981Assignee: Bayer AktiengesellschaftInventors: Horst Harnisch, Peter Rasche
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Patent number: 4264494Abstract: Metal complex compounds which in the form of the free acids correspond to the formula I ##STR1## where A is an aliphatic, carbocyclic or heterocyclic radical,E is an aliphatic or carbocyclic radical,B is a cyano, acyl, substituted sulfonyl, carboxylic acid ester or carboxamide radical, orB and E together with the carbon atoms by which they are linked may be an alicyclic or heterocyclic radical,F is an aliphatic, carbocylic or heterocyclic radical,L is --O--, --COO--, ##STR2## n is 1, 2, 3 or 4, Y is .dbd.CH-- or .dbd.N-- andZ is ##STR3## or the radical of a coupling component, alkyl being of 1 to 4 carbon atoms, andR is hydrogen or unsubstituted or substituted alkyl, cycloalkyl, aryl or acyl and R.sup.1 and R.sup.2 are substituents conventionally present in dyes.The compounds of the formula I give fast dyeings on natural polyamides and synthetic nylons.Type: GrantFiled: August 2, 1978Date of Patent: April 28, 1981Assignee: BASF AktiengesellschaftInventors: Klaus Grychtol, Hans Baumann
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Patent number: 4260757Abstract: Poly[di-1,2-(diazinylidene)-ethene-1,2-diols] having the structure:X--C.sub.4 H.sub.2 N.sub.2 --C(OH).dbd.C(OH)--C.sub.4 H.sub.2 N.sub.2 --C(OH) ].sub.n C(OH)--C.sub.4 H.sub.2 N.sub.2 --Yin which the C.sub.4 H.sub.2 N.sub.2 group is a diazinylidene diradical having each C(OH) group adjacent (ortho) to one but not two ring nitrogen atoms and not adjacent (ortho) to each other; X and Y are terminal formyl (CHO) groups or groups derived from them by oxidation; and n has a value of zero to seven--are prepared by a cyanide ion catalyzed condensation of pyrazine-2,5-dicarboxaldehyde, pyridazine-3,6-dicarboxaldehyde; or pyrimidine-4,6-dicarboxaldehyde as the only aldehydes which provide the requisite structures. The polymers form complexes with metal ions including manganese, which is insoluble, and vanadium, which is soluble.Type: GrantFiled: July 18, 1979Date of Patent: April 7, 1981Inventor: Richard H. Wiley
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Patent number: 4256883Abstract: Stable biologically active aromatic prostacyclin analogues of the formula ##STR1## wherein X represents ##STR2## and R represents hydrogen, a pharmaceutically acceptable cation or a pharmaceutically acceptable lower alkyl group, are useful in the treatment of blood platelet aggregation and vascular constriction.Type: GrantFiled: March 14, 1979Date of Patent: March 17, 1981Assignee: Research CorporationInventors: Kyriacos C. Nicolaou, William E. Barnette, Ronald L. Magolda
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Patent number: 4254123Abstract: Novel imidazoquinoxalines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, --NH.sub.4, alkali metal, alkaline earth metal, magnesium, aluminum and non-toxic, pharmaceutically acceptable amines, X is selected from the group consisting of hydrogen, alkoxy of 1 to 5 carbon atoms and carbamoyl and Y and Z are individually selected from the group consisting of hydrogen and halogen and their non-toxic, pharmaceutically acceptable acid addition salts having anti-allergic activity and their preparation.Type: GrantFiled: July 30, 1979Date of Patent: March 3, 1981Assignee: Roussel UclafInventors: Peter J. Ramm, Alan C. Barnes
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Patent number: 4237292Abstract: Metal complexes of azomethines of the formula ##STR1## are useful for coloring plastics and lacquers in yellow to red shades of excellent fastness properties.Type: GrantFiled: October 26, 1978Date of Patent: December 2, 1980Assignee: Ciba-Geigy CorporationInventors: Francois L'Eplattenier, Andre Pugin, Jost von der Crone
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Patent number: 4237286Abstract: Metal complexes of azomethines of the formula ##STR1## are useful for coloring plastics and lacquers in yellow to red shades of excellent fastness properties.Type: GrantFiled: October 26, 1978Date of Patent: December 2, 1980Assignee: Ciba-Geigy CorporationInventors: Francois L'Eplattenier, Andre Pugin, Jost von der Crone
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Patent number: 4237293Abstract: Metal complexes of azomethines of the formula ##STR1## are useful for coloring plastics and lacquers in yellow to red shades of excellent fastness properties.Type: GrantFiled: October 26, 1978Date of Patent: December 2, 1980Assignee: Ciba-Geigy CorporationInventors: Francois L'Eplattenier, Andre Pugin, Jost von der Crone
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Patent number: 4212810Abstract: Many varieties of harmful insects which attack useful plant crops can be controlled by treating the plants with compositions containing certain novel tetraorganotin compounds wherein three of the four hydrocarbon groups bonded to the tin atom are methyl and the remaining group is phenyl containing specified substituents or heterocyclic and is either bonded directly to the tin atom or separated from the tin atom by one methylene group. The present compounds exhibit unexpectedly superior insecticidal activity relative to prior art organotin compounds containing three methyl groups and a phenyl or an alkyl- substituted phenyl group bonded to the tin atom.Type: GrantFiled: December 21, 1978Date of Patent: July 15, 1980Assignee: M&T Chemicals Inc.Inventors: Melvin H. Gitlitz, John E. Engelhart, David A. Russo
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Patent number: 4181517Abstract: 1,2,3-Thiadiazole-2-id-derivative of the formula ##STR1## in which R.sub.1 is hydrogen or alkyl which may be substituted in one or several places by oxygen or sulfur and wherein R.sub.1 has the meaning as given in the attached specification and wherein X is oxygen or sulfur and B is a univalent metal atom. The compounds have properties suited for controlling the natural growth and natural development of plants and in addition have a superior defoliating property.Type: GrantFiled: April 19, 1978Date of Patent: January 1, 1980Assignee: Schering AktiengesellschaftInventors: Hans-Rudolf Kruger, Reinhart Rusch, Friedrich Arndt