Heavy Metal Or Aluminum Containing Patents (Class 544/225)
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Patent number: 6133259Abstract: Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.Type: GrantFiled: November 9, 1998Date of Patent: October 17, 2000Assignee: University of PittsburghInventors: William E. Klunk, Jay W. Pettegrew, Chester A. Mathis, Jr.
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Patent number: 6127369Abstract: A compound selected from those of formula (I): ##STR1## wherein: X represents N, C or CH,Y represents N when X represents C or CH, or Y represents C or CH when X represents N,R.sub.1 represents an optionally substituted alkyl,R.sub.2 and R.sub.3, which may be identical or different, represent Z or W, as defined in the description,their isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.Type: GrantFiled: June 11, 1999Date of Patent: October 3, 2000Assignee: Adir et CompagnieInventors: Paul Caubere, Gerald Guillaumet, Ivan Rodriguez, Karine Vinter-Pasquier, Catherine Kuehm-Caubere, Stephanie Blanchard, Ghanem Atassi, Alain Pierre, Bruno Pfeiffer, Pierre Renard
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Patent number: 6121443Abstract: Organometallic precursor compounds useful for forming aluminum films by chemical vapor deposition are disclosed. Also disclosed are methods of preparing the organometallic precursor compounds and methods of forming aluminum films.Type: GrantFiled: March 31, 1999Date of Patent: September 19, 2000Assignee: Rohm and Haas CompanyInventor: Hyun-Koock Shin
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Patent number: 6103920Abstract: Disclosed herein is a process for the polymerization of ethylene, norbornenes and styrenes, by contacting in solution a selected nickel compound and a selected compound which is or can coordinated to the nickel with the olefin(s). The polymers produced are useful for films and molding resins.Type: GrantFiled: July 23, 1997Date of Patent: August 15, 2000Assignee: E. I. du Pont de Nemours and CompanyInventors: Lynda Kaye Johnson, Jerald Feldman, Kristina Ann Kreutzer, Stephan James Mclain, Alison Margaret Anne Bennett, Edward Bryan Coughlin, Dennis Scott Donald, Lissa Taka Jennings Nelson, Anju Parthasarathy, Xing Shen, Wilson Tam, Yueli Wang
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Patent number: 6077805Abstract: Hexacoordinated ruthenium and osmium catalysts of the formulae ##STR1## in which M and M' independently of one another are ruthenium or osmium;X, X', Y and Y' independently of one another are anionic ligands, or X and Y and X' and Y' in each case together are bis-anionic ligandsL.sup.1 and L.sup.1' independently of one another are tertiary phosphine;L.sup.2 and L.sup.3 independently of one another are a monodentate ligand, or L.sup.2 and L.sup.3 together are bidentate, neutral electron donor ligands;L.sup.4 is tetradentate, neutral electron donor ligand;L.sup.5 is a bidentate, neutral electron donor ligand; andT and T' indepedently of one another are H or organic substituents, are useful for the synthesis of custom-tailored polymers and for the ring-closing metathesis of olefins.Type: GrantFiled: March 2, 1998Date of Patent: June 20, 2000Assignee: Ciba Specialty Chemicals CorporationInventors: Paul Adriaan Van Der Schaaf, Andreas Hafner, Andreas Muhlebach
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Patent number: 6043363Abstract: Novel aminomethylphosphine ligands have particular substituents on the central carbon atom. Such ligands form coordination complexes that may be catalysts for the polymerization of monomers or other catalytic induced reactions.Type: GrantFiled: March 8, 1999Date of Patent: March 28, 2000Assignee: Symyx Technologies, Inc.Inventors: Anne Marie LaPointe, Anil Guram, Timothy S. Powers, Bernd Jandeleit, Thomas Boussie, Cheryl Lund
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Patent number: 6013798Abstract: Gold thiolates of formula AuSR" or a salt thereof, in which R" is such that HSR" represents: 4,6-dihydroxy-2-mercaptopyrimidine;N-(2-mercaptoacetyl)glycine;N-(3-mercaptopropionyl)glycine; andN-(2-mercaptopropionyl)glycine. The invention provides also processes for preparing novel gold thiolates.Type: GrantFiled: January 20, 1998Date of Patent: January 11, 2000Assignee: Johnson Matthey Public Limited CompanyInventor: Peter T Bishop
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Patent number: 5986074Abstract: The present invention relates to novel metal chelates, exemplified as technetium-99m or rhenium chelates, and to the process of preparing such metal chelates from corresponding ligands. These ligands and their corresponding metal chelates are synthesized to have a cysteinylethylene (EC) structure, a monothiourea (MTU) structure, or a dithiourea (DTU) structure. The present invention further relates to a pharmaceutical composition comprising a metal chelate, for example, a .sup.99m Tc-chelate, to the use of the composition for renal imaging and examination of renal function, and to a kit for preparing such a composition prior to use.Type: GrantFiled: December 18, 1997Date of Patent: November 16, 1999Assignee: Emory UniversityInventors: Luigi G. Marzilli, Malgorzata Lipowska, Lory Hansen, Andrew Taylor, Jr.
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Patent number: 5958914Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is amino, R.sup.2 is hydrogen,R.sup.3 is carboxy,R.sup.4 is heterocyclic(lower)alkylthio wherein said heterocyclic group is pyrazolyl and said lower alkyl group is methyl, andR.sup.5 is halogen; and pharmaceutically acceptable salts thereof.Type: GrantFiled: March 26, 1998Date of Patent: September 28, 1999Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kohji Kawabata, Hirofumi Yamamoto, Yoshiteru Eikyu, Shinya Okuda, Hisashi Takasugi
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Patent number: 5955053Abstract: The present invention relates to novel metal chelates, exemplified as technetium-99m or rhenium chelates, and to the process of preparing such metal chelates from corresponding ligands. These ligands and their corresponding metal chelates are synthesized to have a cysteinylethylene (EC) structure, a thioacetamidethiourea (TATU) structure, or a dithiourea (DTU) structure. The present invention further relates to a pharmaceutical composition comprising a metal chelate, for example, a .sup.99m Tc-chelate, to the use of the composition for renal imaging and examination of renal function, and to a kit for preparing such a composition prior to use.Type: GrantFiled: May 6, 1996Date of Patent: September 21, 1999Assignee: Emory UniversityInventors: Luigi Gaetano Marzilli, Malgorzata Lipowska, Lory Hansen, Andrew Taylor, Jr.
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Patent number: 5942616Abstract: A metal ion coordinated complex crystal is composed of cation of a nitrogen-containing heterocyclic aromatic compound, anion of triiodine and metal ion. The complex crystal can be used as light-polarizing particles having a stable and strong polarizability which is resistant to ultra violet, an excellent heat resistance, excellent moisture resistance and excellent insolubility.Type: GrantFiled: April 16, 1996Date of Patent: August 24, 1999Assignee: Kabushiki Kaisha Toyota Chuo KenkyushoInventors: Hisato Takeuchi, Azusa Tsukigase, Arimitsu Usuki
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Patent number: 5919928Abstract: A phenanthridine derivative metal complex of formula 1 having a large absorption in the near-infrared range and a reduced absorption in the visible range, which phenanthridine derivative metal complex is used in a transparent recording medium: ##STR1## where M is a metal atom, and X is a negative ion.Type: GrantFiled: September 18, 1997Date of Patent: July 6, 1999Assignee: Nippon Paper Industries, Co., Ltd.Inventors: Reiji Ohashi, Yukiko Ryu, Tomoaki Nagai, Hidetoshi Yoshioka
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Patent number: 5912207Abstract: Metal chelates of herbicidal dione compounds of the formula ##STR1## are chemically stable for long periods of time under normal as well as extreme temperature conditions. Chemically stable liquid herbicidal formulations containing metal chelates of the herbicidal compounds of formula (I) and water, an organic solvent or a liquid co-herbicide and processes for producing chemically stable herbicidal compositions containing such metal chelates are also described.Type: GrantFiled: January 31, 1997Date of Patent: June 15, 1999Assignee: Zeneca LimitedInventors: Herbert B. Scher, Jinling Chen
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Patent number: 5892033Abstract: Disclosed is a metal chelate dye which is composed of a metal ion and a ligand that is a methine dye having 2 or more bonding positions capable of coordinate bond to the metal ion at the bonding position. A thermal transfer recording material, an ink used for an ink jet image recording process and a color toner for electrostatic image recording process are also disclosed.Type: GrantFiled: September 4, 1996Date of Patent: April 6, 1999Assignee: Konica CorporationInventors: Tawara Komamura, Akira Onishi, Tatsuo Tanaka, Yoriko Nakayama, Mari Honda, Norio Miura
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Patent number: 5892042Abstract: An acridine derivative metal complex of formula 2 having a large absorption in the near-infrared range and a reduced absorption in the visible range, which acridine derivative metal complex is used in a transparent recording medium: ##STR1## where M is a metal atom, and X is a negative ion.Type: GrantFiled: September 18, 1997Date of Patent: April 6, 1999Assignee: Nippon Paper Industries Co., Ltd.Inventors: Reiji Ohashi, Yukiko Ryu, Tomoaki Nagai, Hidetoshi Yoshioka
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Patent number: 5886203Abstract: A process is provided for the production of metalorganic compounds by reacting a Grignard reagent with a Group II, Group III or Group V metal halide in a tertiary alkyl amine solvent to form a metalorganic adduct, isolating the adduct and dissociating the adduct to leave the metalorganic compound.Type: GrantFiled: July 14, 1997Date of Patent: March 23, 1999Assignee: Secretary of State For Defence Acting Through His Defence Evaluation & Research AgencyInventors: Anthony Copeland Jones, Simon Andrew Rushworth, Trevor Martin, Timothy John Whittaker, Richard William Freer
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Patent number: 5728691Abstract: Derivatives of 7-aminoceph-3-em-4-carboxylic acid with 6-fluoroquinolone derivatives in which the cephem and 6-fluoroquinolone moieties are bound to each other through a carboxamido bond as well as the pharmaceutical compositions containing them are described. These compounds possess antibacterial, growth promoting and probiotic activity.Type: GrantFiled: August 22, 1996Date of Patent: March 17, 1998Assignees: Laboratorios Aranda S.A. De C.V., Judith Marcia Arrieta MunguiaInventor: Miguel Angel Corpi Constantino
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Patent number: 5693310Abstract: Compounds of general Formula I ##STR1## wherein R.sup.3 is a saturated, unsaturated, straight- or branched-chain or cyclic aliphatic hydrocarbon residue of up to 16 carbon atoms or, if R.sup.4 is a hydrogen atom, a cycloalkyl group or an aryl or aralkyl group optionally substituted by one or several C.sub.1 -C.sub.6 -dialkylamino groups or by one or several C.sub.1 -C.sub.6 -alkoxy groups,R.sup.4 is a hydrogen atom, a saturated, unsaturated, straight- or branched-chain or cyclic hydrocarbon residue of up to 16 carbon atoms, orR.sup.3 and R.sup.4 jointly mean a saturated or unsaturated 5- or 6-membered ring optionally substituted or containing an O, S, N atom or oxo substituent, and Y is COOX or CONR.sub.3 R.sub.4,are valuable complexing agents, complexes or complex salts, e.g., for use as NMR or X-ray diagnostic image-enhancement agents or radioactive diagnostic agents.Type: GrantFiled: November 19, 1990Date of Patent: December 2, 1997Assignee: Schering AktiengesellschaftInventors: Heinz Gries, Bernd Raduechel, Hans-Joachim Weinmann, Wolfgang Muetzel, Ulrich Speck
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Patent number: 5681830Abstract: Diarylmethyl piperazine compounds having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors are disclosed. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, cough, and apnea, respiratory depression, cognitive disorders, emesis and gastrointestinal disorders.Type: GrantFiled: August 3, 1994Date of Patent: October 28, 1997Assignee: Delta Pharmaceuticals, Inc.Inventors: Kwen-Jen Chang, Dulce G. Bubacz, Ann O. Davis, Robert W. McNutt, Jr., Mark A. Collins, Michael J. Bishop
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Patent number: 5633256Abstract: This invention relates to derivatives of acrylic acid useful in agriculture (especially as fungicides but also as plant growth regulators, insecticides and nematocides), to processes for preparing them, to agricultural (especially fungicidal) compositions containing them, and to methods of using them to combat fungi, especially fungal infections in plants, to regulate plant growth and to kill or control insect or nematode pests. The invention provides a compound having the formula (I): ##STR1## and stereoisomers thereof, wherein W is a substituted pyridinyl or substituted pyrimidinyl group linked to A by any of its ring carbon atoms; A is either an oxygen atom or S(O).sub.Type: GrantFiled: March 29, 1995Date of Patent: May 27, 1997Assignee: Zeneca LimitedInventors: Vivienne M. Anthony, John M. Clough, Paul DeFraine, Christopher R. A. Godfrey
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Patent number: 5624662Abstract: Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.Type: GrantFiled: June 7, 1995Date of Patent: April 29, 1997Assignee: ImaRx Pharmaceutical CorporationInventors: Evan C. Unger, DeKang Shen
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Patent number: 5624919Abstract: Novel trans-platinum IV complexes which contain heterocycle ligands such as quinoline or isoquinoline, anionic ligands such as halide or sulfate, and which optionally may contain ammonia, or a primary or secondary amine are provided. These complexes have application as pharmaceuticals, in particular as anti-tumor agents.Type: GrantFiled: September 13, 1994Date of Patent: April 29, 1997Assignee: The University of Vermont and State Agricultural CollegeInventor: Nicholas Farrell
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Patent number: 5616750Abstract: A compound of formula (I): ##STR1## n which M is a transition metal ion; A is a counter-ion if required;r, s and t are independently 0 to 3 such that r+s+t is in the range of 1 to 3;R.sup.a, R.sup.b, R.sup.c are each independently hydrogen or CH.sub.2 OR' where R' is hydrogen or an organic group;B and E are independently oxygen, CH.sub.2, NR.sup.d in which R.sup.d is alkyl, hydrogen, alkylcarbonyl, or arylcarbonyl or SO.sub.n where n is 0 or an integer 1 or 2, with the proviso that B and E are not simultaneously CH.sub.2 and that when B is oxygen, NR.sup.d or SO.sub.n, then r cannot be 0, and when E is oxygen, NR.sup.d or SO.sub.n, then t cannot be 0;R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are independently hydrogen, alkyl or alkoxy.Type: GrantFiled: October 6, 1993Date of Patent: April 1, 1997Assignee: SmithKline Beecham plcInventors: David Bell, David Miller, Robin P. Attrill
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Patent number: 5609849Abstract: Compounds such as 4-(s'-methoxy)phenyl-[2'-N-2"-pyridinyl)-p-iodobenzamido]ethylpiperazine have affinity and specificity for serotonin 5-HT.sub.1A receptors.Type: GrantFiled: March 11, 1994Date of Patent: March 11, 1997Assignee: The Trustees of the University of PennsylvaniaInventor: Hank F. Kung
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Patent number: 5608059Abstract: Ion-sensitive compounds have the formula A.sup.2+ B.sup.2- wherein A represents a cation capable of forming a receptor-substrate complex with an anion, and B represents one or more counter anions, the cation being an anion receptor of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group or R.sup.1 and R.sup.2 taken together with the atoms separating them represent the atoms necessary to complete a (2)-cryptand; and,R.sup.3 and R.sup.4 are each independently H or a lower alkyl group having from 1 to 4 carbon atoms, or R.sup.3 and R.sup.4 taken together represent an ethylene bridging group.The compounds may be used for sensing anions.Type: GrantFiled: December 19, 1994Date of Patent: March 4, 1997Assignee: Eastman Kodak CompanyInventors: Trevor J. Wear, Christopher P. Moore, Alistair J. Goulden, Paul D. Beer, Nicholas C. Fletcher
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Patent number: 5602076Abstract: This invention relates to derivatives of acrylic acid useful in agriculture (especially as fungicides but also as plant growth regulators, insecticides and nematocides), to processes for preparing them, to agricultural (especially fungicidal compositions containing them, and to methods of using them to combat fungi, especially fungal infections in plants, to regulate plant growth and to kill or control insect or nematode pests.The invention provides a compound having the formula (I): ##STR1## and stereoisomers thereof, wherein W is a substituted pyridinyl or substituted pyrimidinyl group linked to A by any of its ring carbon atoms; A is either an oxygen atom or S(O).sub.Type: GrantFiled: March 29, 1995Date of Patent: February 11, 1997Assignee: Zeneca LimitedInventors: Vivienne M. Anthony, John M. Clough, Paul DeFraine, Christopher R. A. Godfrey
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Patent number: 5602236Abstract: Metal-containing steroid mimic complexes are provided. Compositions containing a metal ion incorporated into a steroid skeleton structure and ligands useful in the preparation of such compositions are also provided. The metal ion is preferably a radionuclide, such as technetium, rhenium or gallium. Methods for using the metal complexes for diagnostic and therapeutic purposes are further provided.Type: GrantFiled: April 8, 1994Date of Patent: February 11, 1997Assignee: Mallinckrodt Medical, Inc.Inventor: Raghavan Rajagopalan
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Patent number: 5587144Abstract: Heterocyclic chelating agents and salts thereof of formula I: ##STR1## wherein X represents a bond, O or S, or a group CHR.sup.1 or NR.sup.3 ; each R.sup.1 represents H, a group OR.sup.3 or NR.sup.3 R.sup.3, or an alkyl or alkoxyalkyl group optionally substituted by a hydroxyl group or by a group NR.sup.3 R.sup.3 or CON.sup.3 R.sup.3 ;each R.sup.2 represents H, or an alkyl or alkoxy group optionally substituted by a hydroxyl or alkoxy group;each R.sup.3 represents H, an optionally hydroxylated alkyl group or a group CH.sub.2 Y;Y represents a group COZ, CON(OH)R.sup.4, POZ.sub.2 or SO.sub.2 Z,Z represents a group OR.sup.4, NR.sup.4 R.sup.4 or ##STR2## where each R.sup.11 is H, a hydroxyl group or an optionally hydroxylated alkyl group, s is 0, 1 or 2, and W is CHR.sup.11, NR.sup.11 or an oxygen atom; andeach R.sup.4 represents H, or an optionally mono- or poly-hydroxylated alkyl, alkoxyalkyl or polyalkoxyalkyl group;with the provisos that where s is 0 then W is CHR.sup.Type: GrantFiled: June 6, 1995Date of Patent: December 24, 1996Assignee: Nycomed Imaging ASInventors: Torsten Alm en, Arne Berg, Harald Dugstad, Jo Klaveness, Klaus D. Krautwurst, P.ang.l Rongved
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Patent number: 5567815Abstract: An anionic initiator system formed by the reaction product of: (1) an organolithium compound with (2) the reaction product of (a) a secondary amine and (b) diisopropenyl benzene, initiates polymerization to produce a polymer containing tertiary amine functional sites incorporated at the head of the polymer chain. A subclass of these polymers can be compounded to exhibit reduced hysteresis over conventionally prepared polymers.Type: GrantFiled: July 18, 1994Date of Patent: October 22, 1996Assignee: Bridgestone CorporationInventors: James E. Hall, David F. Lawson, Thomas A. Antkowiak
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Patent number: 5559108Abstract: Novel cephem derivatives represented by the general formula ##STR1## in which the Acyl substituent is a group of the formula ##STR2## where Ar is a substituted phenyl or optionally substituted naphthyl or benzthiazolyl group and A is a substituted-pyridinium group are gram-positive antibiotics, especially useful in the treatment of diseases caused by methicillin-resistant Staphylococcus aureus.Type: GrantFiled: May 22, 1995Date of Patent: September 24, 1996Assignee: Bristol-Myers Squibb CompanyInventors: Choung U. Kim, Muzammil M. Mansuri, Peter F. Misco, Jr., John A. Wichtowski, Joanne J. Bronson, Stanley V. D'Andrea, Thomas W. Hudyma
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Patent number: 5554357Abstract: Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.Type: GrantFiled: September 30, 1994Date of Patent: September 10, 1996Assignee: Mallinckrodt Medical, Inc.Inventor: Raghavan Rajagopalan
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Patent number: 5552409Abstract: This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula ##STR1## wherein A, Q, D and R.sup.1 are as defined within, compositions containing these compounds and methods of controlling agricultural and mammalian fungal diseases.Type: GrantFiled: March 31, 1994Date of Patent: September 3, 1996Assignee: Rohm and Haas CompanyInventors: Enrique L. Michelotti, Anne R. Egan, Ronald Ross, Jr., Willie J. Wilson
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Patent number: 5532373Abstract: An aluminate complex represented by formula (I): ##STR1## with the groups in the aluminate complex as defined in the specification, and which is capable of radical generation upon photoexcitation; a photopolymerizable composition comprising an ethylenically unsaturated polymerizable compound and the aluminate complex; and an image-forming material comprising a support, an organoaluminum compound anion represented by formula (I'): ##STR2## with the groups in the organoaluminum compound anion as defined in the specification, and a photobleachable dye; are disclosed.Type: GrantFiled: September 22, 1994Date of Patent: July 2, 1996Assignee: Fuji Photo Film Co., Ltd.Inventors: Hirotaka Matsumoto, Jun Yamaguchi, Naoto Yanagihara, Hisashi Yamamoto
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Patent number: 5530139Abstract: A condensed heterocyclic compound having a structure represented by formula (I): ##STR1## wherein the substituents are as defined in the specification herein.Type: GrantFiled: May 31, 1994Date of Patent: June 25, 1996Assignee: Showa Denko Kabushiki KaishaInventors: Yoshihiro Saida, Yoshiaki Ikenoue, Reiko Ichikawa
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Patent number: 5527905Abstract: Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R.sup.1, R.sup.2 and R.sup.7 are various organic groups, n is 0, 1 or 2 and X is a direct carbon-carbon bond or lower alkylene) show valuable anti-tumor activity and may be prepared by reacting an amine-platinum complex with a compound providing the group represented by Z.Type: GrantFiled: November 18, 1994Date of Patent: June 18, 1996Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Tomoyuki Shibata, Yukiko Kameyama, Kimio Iino, Shigeki Muramatsu, Tomowo Kobayashi, Toshihiko Hashimoto
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Patent number: 5516940Abstract: A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from the phosphorous or germanium core.Type: GrantFiled: April 29, 1994Date of Patent: May 14, 1996Assignee: Curators of the University of MissouriInventors: Kattesh V. Katti, Wynn A. Volkert, Alan R. Ketring, Prahlad R. Singh
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Patent number: 5514799Abstract: Nonlinear optical compounds having structures with delocalized resonance configurations corresponding to: ##STR1## wherein A.sub.1 and A.sub.2 are independently selected from electron withdrawing moieties; R.sub.1 and R.sub.2 are independently selected from aromatic rings, heteroaromatic rings and fused ring systems consisting of two or three aromatic or heteroaromatic rings; n and m are integers from one to five, and D.sub.1 and D.sub.2 are independently selected from hydrogen, electron donating groups and polymer attachment groups, with the proviso that at least one of D.sub.1 and D.sub.2 is an electron donating group. Polymers blended with, cured with, or having pendant side chains of the disclosed nonlinear optical materials and exhibiting second order nonlinear optical properties are also disclosed.Type: GrantFiled: August 2, 1993Date of Patent: May 7, 1996Assignee: Enichem S.p.A.Inventors: Pushkara R. Varanasi, Kwan-Yue A. Jen, King Y. Wong, Robert M. Mininni
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Patent number: 5512687Abstract: Novel ruthenium complexes for use as immunosuppressive agents to prevent or significantly reduce graft rejection in organ and bone marrow transplantation are described. The ruthenium complexes can also be used as an immunosuppressant drug for T-lymphocyte mediated autoimmune diseases, such as diabetes, and may be useful in alleviating psoriasis and contact dermatitis.Type: GrantFiled: October 28, 1994Date of Patent: April 30, 1996Assignee: Procept, Inc.Inventor: Cecilia M. Bastos
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Patent number: 5506357Abstract: A photostable cyanine dye possessing a structure represented by the general formula I or II:.PHI..sup.+ -L=.PSI..multidot.Q.sup.- (I).PHI.=L-.PSI..sup.+ .multidot.Q.sup.- (II)wherein .PHI. denotes a monovalent or divalent residue of thiazole ring, oxazole ring, selenazole ring, imidazole ring, pyridine ring, indolenine ring, benzoindolenine ring or dibenzoindolenine ring which may have an aromatic ring condensed thereto, .PSI. denotes a divalent or monovalent residue of thiazole ring, oxazole ring, selenazole ring, imidazole ring, pyridine ring, indolenine ring, benzoindolenine ring or dibenzoindolenine ring which may have an aromatic ring condensed thereto, L denotes a polymethine connecting group for the formation of a cyanine dye, and Q.sup.- denotes an anion represented by the general formula III: ##STR1## wherein M denotes a transition metal atom, R.sup.1, R.sup.2, R.sup.3 and R.sup.Type: GrantFiled: June 6, 1994Date of Patent: April 9, 1996Assignee: TDK CorporationInventor: Kenryo Namba
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Patent number: 5502065Abstract: The present invention provides compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof.Type: GrantFiled: September 21, 1994Date of Patent: March 26, 1996Assignee: Pfizer Inc.Inventors: Alan D. Brown, Roger P. Dickinson, Martin J. Wythes
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Patent number: 5500297Abstract: Stable electron acceptor compositions are composed of a plurality of pillared metal complexes disposed on a supporting substrate. At least one Group VIII metal at zero valence is entrapped within this matrix. The complexes comprise from one to about 100 units of the formula:--(Y.sup.1 O.sub.3 --Z--Y.sup.2 O.sub.3)Me.sup.1 --Y.sup.1 and Y.sup.2 being phosphorus or arsenic; Z being a divalent group which reversibly forms a stable reduced form and contains two conjugated cationic centers having a negative E.degree..sub.red value; and Me.sup.1 being a trivalent or tetravalent metal of Group III, IVA, or IVB having an atomic number of at least 21 or a lanthanide. The units are bound to the substrate through a divalent linking group. Counter anions balance the charge of Z. The compositions can be used in the decomposition of water to yield hydrogen gas, the sensing of oxygen, and as catalysts.Type: GrantFiled: August 9, 1993Date of Patent: March 19, 1996Assignee: The Trustees of Princeton UniversityInventors: Mark E. Thompson, Jonathan L. Snover, Lori A. Vermeulen
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Patent number: 5466692Abstract: This invention relates to substituted pyridopyrimidinones of general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are independently H, lower alkyl containing 1 to 6 carbon atoms, hydroxyalkyl containing 1 to 6 carbon atoms, formyl, carbonylalkyl containing 1 to 6 carbon atoms, carboxy, or carboxyalkyl containing 1 to 6 carbon atoms; R.sup.3 and R.sup.4 are independently H, lower alkyl containing 1 to 6 carbon atoms, hydroxy; R.sup.3a and R.sup.4a are H, and when taken together with R.sup.3 and R.sup.4 respectively comprise a carbonyl; with the proviso that at least one of the groups R1 and R.sup.2 must be hydroxyalkyl, formyl, carbonylalkyl containing 1 to 6 carbon atoms, carboxy, or carboxyalkyl containing 1 to 6 carbon atoms; or R.sup.3 and R.sup.4 must be hydroxy or taken together with R.sup.3a and R.sup.4a respectively must comprise a carbonyl; n is 0 to 3; Ar.sup.Type: GrantFiled: January 10, 1994Date of Patent: November 14, 1995Assignee: American Home Products CorporationInventor: John W. Ellingboe
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Patent number: 5466804Abstract: Novel silver-carboxylate/1,2-diazine compounds having the formula: ##STR1## wherein: R.sup.1 represents either an alkyl, aralkyl, cycloalkyl, or alkenyl group of up to 29 carbon atoms; or an aryl group of up to 14 carbon atoms; andand R.sup.2 represents either hydrogen, an alkyl group, a cycloalkyl group fused to the 1,2-diazine ring, or the atoms necessary to complete a 5- or 6-membered aromatic ring fused to the 1,2-diazine ring.The novel silver-carboxylate/1,2-diazine compounds are coordination compounds of two silver-carboxylate molecules and two molecules comprising a 1,2-diazine nucleus. These compounds can serve as the silver source in a black-and-white thermographic or photothermographic element or as the oxidizing agent for a dye-based thermographic or photothermographic color-imaging construction.Type: GrantFiled: June 6, 1994Date of Patent: November 14, 1995Assignee: Minnesota Mining and ManufacturingInventors: David R. Whitcomb, William C. Frank
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Patent number: 5451563Abstract: Fungicidal heterocyclic silyl compounds of the general formula ##STR1## have been discovered wherein Het is a six membered heterocyclic moiety; R is hydrogen or a trisubstituted silyl group; R.sup.1, R.sup.2 and R.sup.3 are independently selected from substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or pyridyl groups; m is 0 or 1 and n is zero, one or two.Type: GrantFiled: March 16, 1994Date of Patent: September 19, 1995Assignee: Rohm and Haas CompanyInventors: Steven H. Shaber, Edward M. Szapacs, Reynolds Charles H.
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Patent number: 5420099Abstract: A compound having the formula ##STR1## wherein A is CR.sub.7 ; and R.sup.1 through R.sup.7 are substituents such as hydrogen, halogen, branched and straight chain hydrocarbons, cyclic hydrocarbons, aromatics, and sulfur and nitrogen containing functional groups. Further, R.sup.5 and R.sup.6 may be taken together with the atom to which they are attached to form a group ##STR2## in which R.sup.9 and R.sup.10 are further functional groups. The compounds are useful in herbicidal compositions, particularly in combination with carriers and surfactants. A process for making this compound is also presented.Type: GrantFiled: December 21, 1992Date of Patent: May 30, 1995Assignee: Shell Research LimitedInventor: Trevor W. Newton
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Patent number: 5410052Abstract: Mthods and apparatus for the extraction of a ligand such as molecular oxygen from a first fluid environment and for release of a ligand such as molecular oxygen, as well as ligand carrier compounds therefore comprising linear, pentadentate polyalkylamines and transition metal ions. The carrier compounds have the general formula: ##STR1## where, each of R.sub.1 and R.sub.2 is independently an organic group including a sulfur, an oxygen or a nitrogen coordinated to M;each of m, n. o, and p is 1, 2 3, or 4;X is selected from the group consisting of 2,6-pyridyl, 2,6-piperidyl, 2,5pyrrolyl, 2,4-imidazolyl, substituted heterocyclic amines, --O--, --S-- >P--R.sub.3, and >N--R.sub.3 where R.sub.3 is hydrogen, lower alkyl, or aralkyl; andM is a transition metal ion.Type: GrantFiled: September 25, 1990Date of Patent: April 25, 1995Assignee: The Regents of the University of CaliforniaInventors: Kevin M. Smith, Joseph P. Ciccone, N. Venkata Ramana
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Patent number: 5409915Abstract: Novel bis(platinum) (IV) complexes coupled via diamine bridging agents are taught as well as methods for their preparation. These complexes are to be used as pharmaceutical agents, e.g., for the treatment of cancer and parasitic diseases.Type: GrantFiled: September 14, 1993Date of Patent: April 25, 1995Assignee: The University of Vermont and State Agricultural CollegeInventors: Nicholas Farrell, Silvano Spinelli, Mariella Valsecchi, Ernesto Menta
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Patent number: 5384108Abstract: Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. The complexes are represented by the formula of: ##STR1## wherein A is --CHR.sup.2 --CHR.sup.3 -- or ##STR2## M.sup.+Z is a paramagnetic ion of an element with an atomic number of 21-29, 42-44 58-70, and a valence, Z, of +2 or +3; R.sup.1 groups may be the same or different and are selected from the group consisting of --O.sup.- and ##STR3## The R.sup.4, R.sup.5 and R.sup.6 groups are as defined in the disclosure. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.Type: GrantFiled: April 24, 1989Date of Patent: January 24, 1995Assignee: Mallinckrodt Medical, Inc.Inventor: Raghavan Rajagopalan
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Patent number: 5378708Abstract: Compounds of the formula: ##STR1## wherein A, Q and R.sup.2 to R.sup.5 are as defined in the text, compositions containing them and methods for using them to control insects, acarids and fungi.Type: GrantFiled: May 13, 1993Date of Patent: January 3, 1995Assignee: E. I. Du Pont de Nemours and CompanyInventors: Joseph E. Drumm, III, Renee M. Lett, Thomas M. Stevenson
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Patent number: 5374632Abstract: 2,3-Dihydro-1-(8-methyl-1,2,4-triazolo [4,3-b]pyridazin-6-yl)-4(1H)-pyridinone has been prepared in substantially pure form and has been found to be useful for alleviating bronchial spasms in mammals. Synthesis of this material through phenylselenyl intermediates is described.Type: GrantFiled: August 17, 1992Date of Patent: December 20, 1994Assignee: Merrell Dow Pharmaceuticals Inc.Inventor: Robert J. Cregge