Heavy Metal Or Aluminum Containing Patents (Class 544/225)
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Publication number: 20080142759Abstract: The present invention relates to the use of pyridine N-oxide based azo dyes and their metal complexes in optical layers for optical data recording, preferably for optical data recording using a blue laser with a wavelength up to 450 nm or a red laser with a wavelength up to 650 nm. The invention further relates to a write only read many (WORM) type optical recording medium capable of recording and reproducing information with radiation of a blue or red laser, which employs a pyridine N-oxide based azo dye or a respective metal complex in the optical layer.Type: ApplicationFiled: December 7, 2005Publication date: June 19, 2008Inventor: Christophe Pays
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Patent number: 7381479Abstract: Emissive phosphorescent organometallic compounds are described that produce improved electroluminescence, particularly in the blue region of the visible spectrum. Organic light emitting devices employing such emissive phosphorescent organometallic compounds are also described. Also described is an organic light emitting layer including a host material having a lowest triplet excited state having a decay rate of less than about 1 per second; a guest material dispersed in the host material, the guest material having a lowest triplet excited state having a radiative decay rate of greater than about 1×105 or about 1×106 per second and wherein the energy level of the lowest triplet excited state of the host material is lower than the energy level of the lowest triplet excited state of the guest material.Type: GrantFiled: May 3, 2005Date of Patent: June 3, 2008Assignees: The University of Southern California, The Trustees of Princeton University, Universal Display CorporationInventors: Sergey Lamansky, Mark E. Thompson, Vadim Adamovich, Peter I. Djurovich, Chihaya Adachi, Marc A. Baldo, Stephen R. Forrest, Raymond Kwong
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Patent number: 7375224Abstract: The present invention provides an adenine modified solid, ordered, mesoporous, bifunctional, organo-inorganic silica-based catalyst, its method of preparation and also a process for the production of cyclic carbonates of the formula hereinbelow wherein R?H, CH2Cl, CH3, C4H9, C6H11, C6H5.Type: GrantFiled: May 23, 2006Date of Patent: May 20, 2008Assignee: Council of Scientific and Industrial ResearchInventors: Darbha Srinivas, Rajendra Srivastava, Paul Ratnasamy
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Publication number: 20080113216Abstract: It is an object of the present invention to provide a substance capable of emitting phosphorescence. In addition, it is an object of the present invention to provide a light-emitting element that is excellent in chromaticity. One aspect of the present invention is an organometallic complex having a structure represented by a general formula (1). In the general formula (1), R1 to R4 are each any one of hydrogen, a halogen element, an acyl group, an alkyl group, an alkoxyl group, an aryl group, a cyano group, and a heterocyclic group. In addition, R5 to R13 are each any one of hydrogen, an acyl group, an alkyl group, an alkoxyl group, an aryl group, a heterocyclic group, and an electron-withdrawing group. An organometallic complex having such a structure can emit phosphorescence with higher emission intensity.Type: ApplicationFiled: December 1, 2005Publication date: May 15, 2008Applicant: Semiconductor Energy Laboratory Co., Ltd.Inventors: Hideko Inoue, Satoko Shitagaki, Satoshi Seo
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Publication number: 20080113954Abstract: Supramolecular complexes that target and cleave DNA are provided. The supramolecular complexes include at least one metal-to-ligand charge transfer (MLCT) light absorbing unit, at least one Pt based DNA binding unit, and at least one bridging unit that serves to connect the components. The Pt-based DNA binding unit binds the complex to DNA, and the MLCT unit absorbs light, thereby sensitizing molecular oxygen to produce reactive oxygen species in close proximity to the complex and the bound DNA. The reactive oxygen species cleave the bound DNA.Type: ApplicationFiled: September 7, 2007Publication date: May 15, 2008Inventors: Karen J. Brewer, Brenda Winkel
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Patent number: 7365140Abstract: Organometallic complexes suitable as olefin metathesis catalysts are provided. The complexes are Group 8 transition metal carbenes bearing a cationic substituent and having the general structure (I) wherein M is a Group 8 transition metal, L1 and L2 are neutral electron donor ligands, X1 and X2 are anionic ligands, m is zero or 1, n is zero or 1, and R1, W, Y, and Z are as defined herein. Methods for synthesizing the complexes are also provided, as are methods for using the complexes as olefin metathesis catalysts.Type: GrantFiled: June 9, 2005Date of Patent: April 29, 2008Assignee: UTI Limited PartnershipInventors: Warren Edward Piers, Patricio Eduardo Romero Guajardo
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Patent number: 7354662Abstract: An electroluminescence device having a layer containing a specific metal coordination compound is provided. The metal coordination compound is represented by formula (1) below: MLmL?n,??(1) wherein M is a metal atom of Ir, Pt, Rh or Pd; L and L? are mutually different bidentate ligands; m is 1, 2 or 3 and n is 0, 1 or 2 with the proviso that m+n is 2 or 3; a partial structure MLm is represented by formula (2) shown below and a partial structure ML?n is represented by formula (3) or (4) shown below: The metal coordination compound of the formula (1) is characterized by having at least one aromatic substituent for at least one of CyN1, CyN2, CyC1 and CyC2. The metal coordination compound having the aromatic substituent is effective in providing high-efficiency luminescence, long-term high luminance, and less deterioration by current passing.Type: GrantFiled: August 12, 2005Date of Patent: April 8, 2008Assignee: Canon Kabushiki KaishaInventors: Akira Tsuboyama, Shinjiro Okada, Takao Takiguchi, Seishi Miura, Takashi Moriyama, Jun Kamatani, Manabu Furugori
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Publication number: 20080058517Abstract: There are provided compounds of Ir(III) having ?-diketimine ligands. The complexes having Formulae I: where: L is the same or different at each occurrence and is a cyclometalating bidentate monoanionic ligand coordinated through a nitrogen atom and a carbon atom; R1 and R3 can be the same or different and are independently selected from the group consisting of hydrogen, halogen, alkyl, aryl, alkylaryl and heterocyclic groups; and R10 and R11 can be the same or different and are independently selected from the group consisting of hydrogen, halogen, alkyl, aryl, alkylaryl, trialkylsilyl, triarylsilyl, and heterocyclic groups; and R2 is selected from the group consisting of hydrogen, alkyl, aryl, alkylaryl, heterocyclic groups, and fluorine wherein adjacent R groups can join together to form 5- or 6-membered rings. R8 is H, F, or alkyl There are also provided electronic devices containing such compounds.Type: ApplicationFiled: September 6, 2006Publication date: March 6, 2008Inventors: Alexander Zak Bradley, Jeffrey A. Merlo
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Patent number: 7321037Abstract: A photosensitizer dye is provided. The photosensitizer dye contains a Ru complex represented by the following formula (1): wherein Y1 and Y2 independently represent hydrogen atom (H), lithium (Li), sodium (Na) or tetra-alkyl ammonium groups (as represented by the following general formula (2)). wherein A, B, C and D independently represents CmH2m+1 (m=1˜6).Type: GrantFiled: September 21, 2006Date of Patent: January 22, 2008Assignee: National Central UniversityInventors: Chun-Guey Wu, Chia-Yuan Chen, Shi-Jhang Wu
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Publication number: 20070267959Abstract: Provided are a high-efficiency, photoluminescent heteronuclear copper (I)-iridium (III) complex and an organic electroluminescent device using the complex. The photoluminescent heteronuclear copper (I)-iridium (III) complex can be used to form an organic layer of an organic electroluminescent device, can emit light of 590-630 nm as a high-efficiency, photoluminescent material, and provides a high brightness and a low turn-on voltage.Type: ApplicationFiled: March 27, 2007Publication date: November 22, 2007Inventors: Das Rupasree Ragini, Hee-Kyung Kim, Byoung-Ki Choi, Yi-Yeol Lyu, Young-Hun Byun, O-Hyun Kwon, Che-Un Yang, Jung-Bae Song
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Publication number: 20070270605Abstract: The present invention provides an improved process for the preparation of carbamates with high selectivity of pharmaceutical interest by an eco-friendly, non-toxic, phosgene-/isocyanate-/CO-free clean route through a reaction of amine, organic halide compound and carbon dioxide in the presence of a solid, reusable catalyst at moderate conditions and does not require additional cocatalyst/promoter as well as solventType: ApplicationFiled: May 22, 2006Publication date: November 22, 2007Inventors: Darbha Srinivas, Rajendra Srivastava, Paul Ratnasamy
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Publication number: 20070265443Abstract: A photosensitizer dye is provided. The photosensitizer dye contains a Ru complex represented by the following formula (1): wherein Y1 and Y2 independently represents hydrogen atom (H), lithium (Li), sodium (Na) or tetra-alkyl ammonium groups (as represented by the following general formula (2)). Formula (2): wherein A, B, C and D independently represents CmH2m+1 (m=1˜6).Type: ApplicationFiled: September 21, 2006Publication date: November 15, 2007Applicant: NATIONAL CENTRAL UNIVERSITYInventors: Chun-Guey Wu, Chia-Yuan Chen, Shi-Jhang Wu
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Publication number: 20070196689Abstract: Provided are an organometallic complex providing highly efficient phosphorescence and an organic electroluminescence device using the organometallic complex represented by Formula 1: MLmL?n where M is Ir, Os, Pt, Pb, Re, Ru or Pd, L and L? are different bidentate ligands, m is 1, 2 or 3, and n is 3?m. The organometallic complex can be used to form an organic layer of the organic electroluminescence device, efficiently emits light of a wavelength corresponding to red light, and has high brightness and low operating voltage.Type: ApplicationFiled: December 18, 2006Publication date: August 23, 2007Inventors: Das Rupasree Ragini, Hee-Kyung Kim, O-Hyun Kwon, Myeong-Suk Kim, Shinichiro Tamura, Jong-Jin Park, Che-Un Yang, Yi-Yeol Lyu, Young-Hun Byun
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Publication number: 20070184303Abstract: Provided is a cyclometalated transition metal complex represented by Formula 1: The cyclometalated transition metal complex contains a new ancillary ligand having a carboxylate acid or the like connected to a hetero ring, so that it can efficiently emit red light from a phosphorous material through intersystem crossing (ISC) to form triplet excitons and then metal to ligand charge transfer (MLCT). An organic light emitting device manufactured using the transition metal complex shows excellent luminous efficiency and external quantum efficiency.Type: ApplicationFiled: December 6, 2006Publication date: August 9, 2007Inventors: Young-Hun Byun, Hee-Kyung Kim, Das Rupasree Ragini, O-Hyun Kwon, Yi-Yeol Lyu, Lyong-Sun Pu, Shinichiro Tamura
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Publication number: 20070178332Abstract: Provided are an organometallic complex providing highly efficient phosphorescence and an organic electroluminescence device using the same. The organometallic complex can be used to form an organic layer of the organic electroluminescence device, efficiently emits light of a wavelength corresponding to red light, and has high brightness and low operating voltage.Type: ApplicationFiled: December 18, 2006Publication date: August 2, 2007Inventors: Das Rupasree Ragini, Che-Un Yang, Young-Hun Byun, O-Hyun Kwon, Lyong-Sun Pu, Shinichiro Tamura, Woon-Jung Paek, Myeong-Suk Kim, Hee-Kyung Kim, Jong-Jin Park
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Patent number: 7250510Abstract: The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.Type: GrantFiled: August 23, 2006Date of Patent: July 31, 2007Assignee: Total Synthesis, Ltd.Inventors: Michael G. Organ, Christopher J. O'Brien, Assam (Eric) B. Kantchev
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Patent number: 7250512Abstract: The present invention is generally directed to electroluminescent Ir(III) complexes which have emission maxima in the red-orange to red region of the visible spectrum and devices that are made with the Ir(III) complexes.Type: GrantFiled: October 31, 2002Date of Patent: July 31, 2007Assignee: E. I. du Pont de Nemours and CompanyInventors: Daniel David Lecloux, Viacheslav A. Petrov, Ying Wang
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Patent number: 7238437Abstract: A light-emitting material comprises a compound having a partial structure represented by the following formulas (8), (20) and tautomers thereof: wherein the variables are as defined in the specification.Type: GrantFiled: May 13, 2004Date of Patent: July 3, 2007Assignee: Fujifilm CorporationInventors: Tatsuya Igarashi, Keizo Kimura, Kazumi Nii
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Patent number: 7238806Abstract: An organometallic complex according to the present invention comprises a structure represented by the following general formula (1). In the formula, R1 to R5 are any one selected from the group consisting of hydrogen, a halogen element, an acyl group, an alkyl group, an alkoxyl group, an aryl group, a cyano group, and a heterocyclic group, Ar is an aryl group having an electron-withdrawing group or a heterocyclic group having electron-drawing group, and M is an element of Group 9 or an element of Group 10.Type: GrantFiled: December 28, 2004Date of Patent: July 3, 2007Assignee: Semiconductor Energy Laboratory Co., Ltd.Inventors: Hideko Inoue, Satoshi Seo, Satoko Shitagaki, Hiroko Abe
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Patent number: 7232616Abstract: A class of organic metal complexes with mixed ligands for organic light emitting diodes are designed and characterized as the formula:(L2L3M)n. In this formula: L2 is a bidentate ligand which has at least one coordinate atom of oxygen; L3 is a tridentate ligand with three chelate points; M is trivalent metal selected from the group consisting of Al, Ga, In, Tl, and Ir; and n is an integer of from 1 to 2. In Formula (3), X, Y independently represent CH or N and II, III are unsubstituted or substituted aryl or heteroalkyl groups. The substituent groups can be alkyl having 1–8 carbon atoms, halogen, cyano, amino, amido, sulfonyl, carbonyl, aryl, or heteroalkyl groups such as furan, thiophene, pyrrole, pyridine, etc.Type: GrantFiled: January 28, 2003Date of Patent: June 19, 2007Assignee: Tsinghua UniversityInventors: Yong Qiu, Juan Qiao
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Patent number: 7214794Abstract: The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumorsType: GrantFiled: August 17, 2004Date of Patent: May 8, 2007Assignee: Bracco S.p.A.Inventors: Bruno Macchia, Aldo Balsamo, Marco Macchia, Mario Del Tacca, Romano Danesi
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Patent number: 7166368Abstract: The present invention is generally directed to electroluminescent Pt(II) complexes which have emission maxima across the visible spectrum, and devices that are made with the Pt(II) complexes.Type: GrantFiled: October 31, 2002Date of Patent: January 23, 2007Assignee: E. I. du Pont de Nemours and CompanyInventors: Daniel David Lecloux, Viacheslav A. Petrov, Ying Wang, Eric Maurice Smith
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Patent number: 7122668Abstract: The present invention concerns novel platinum complexes in which at least one of the amine ligand is a non-planar heterocyclic aliphatic amine. The platinum complexes may be in a trans or cis configuration and were found to posses therapeutic activites. Thus, the present concerns novel platinum complexes, pharmaceutical compositions comprising them and other uses thereof.Type: GrantFiled: August 21, 2002Date of Patent: October 17, 2006Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Yechezkel Barenholz, Dan Gibson, Yousef Najajreh, Elena Khazanov
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Patent number: 7094897Abstract: The present invention describes novel organometallic compounds which are phosphorescence emitters. Such compounds can be used as active components (=functional materials) in a series of different types of application which can be classed within the electronics industry in the broadest sense. The compounds according to the invention are described by the formulae (I), (Ia), (II) and (IIa).Type: GrantFiled: April 3, 2002Date of Patent: August 22, 2006Assignee: Covion Organic Semiconductors GmbHInventors: Philipp Stossel, Hubert Spreitzer, Heinrich Becker
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Patent number: 7024068Abstract: Complexes of organic ligands with a metal ion exhibit unique conformation and spectroscopic properties upon changes in oxidation state of the metal ion. The metal is a redox-active metal ion and may possess additional ligands bonded to it. The organic ligand has three “arms” that are linked together at a central atom; each arm contains atoms that may also coordinate to the metal ion. At least two of the arms possess chromophoric properties. At least one arm contains two different groups that may coordinate to the metal ion. In one oxidation state, a first atom binds to the metal. In a second oxidation state, a second atom binds to the metal. This change in coordination of the metal ion results in a rotation of one of the arms, which changes the orientation of another group, which inverses the orientation of the two chromophoric species with respect to one another.Type: GrantFiled: December 23, 2003Date of Patent: April 4, 2006Assignee: New York UniversityInventors: James W. Canary, Suffen Zahn
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Patent number: 7002013Abstract: A series of Pt(II) complexes having the following formula are disclosed: X1 and X2 independently are C or N, X1 can also locate at another position of the hexagonal ring, when X1 is N; R1 is H, C1–C8 alkyl, or C1–C4 perfluoroalkyl, R2 is H, R1 and R2 together are C4–C8 alkylene, or R1 and R2 together are bridged carbocyclic C4–C12 alkylene, when X2 is C; R1 is H, C1–C8 alkyl, or C1–C4 perfluoroalkyl, and R2 is omitted, when X2 is N; R7 is H or methyl, and R8 is omitted, when X1 is N; R7 is H or methyl, R8 is H or methyl, or R7 and R8 together are when X1 is C.Type: GrantFiled: September 23, 2004Date of Patent: February 21, 2006Assignee: National Tsing Hua UniversityInventors: Yun Chi, Pi-Tai Chou, Sheng-Yuan Chang, Jakka Kavitha, Yu-Tai Tao
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Patent number: 6974639Abstract: An electroluminescence device having a layer containing a specific metal coordination compound is provided. The metal coordination compound is represented by formula (1) below: MLmL?n??(1), wherein M is a metal atom of Ir, Pt, Rh or Pd; L and L? are mutually different bidentate ligands; m is 1, 2 or 3 and n is 0, 1 or 2 with the proviso that m+n is 2 or 3; a partial structure MLm is represented by formula (2) shown below and a partial structure ML?n is represented by formula (3) or (4) shown below: The metal coordination compound of the formula (1) is characterized by having at least one aromatic substituent for at least one of CyN1, CyN2, CyC1 and CyC2. The metal coordination compound having the aromatic substituent is effective in providing high-efficiency luminescence, long-term high luminance, and less deterioration by current passing.Type: GrantFiled: March 6, 2002Date of Patent: December 13, 2005Assignee: Canon Kabushiki KaishaInventors: Akira Tsuboyama, Shinjiro Okada, Takao Takiguchi, Seishi Miura, Takashi Moriyama, Jun Kamatani, Manabu Furugori
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Patent number: 6965028Abstract: This invention features a supramolecule having the following structure: M is a transition metal atom that is rhenium (Re), manganese (Mn), chromium (Cr), molybdenum (Mo), tungsten (W), iron (Fe), ruthenium (Ru), or osmium (Os); Y is a nitrogen-based didentate ligand; A is O, S, Se, or Te; R is C3˜C16 alkyl, (CH2)n-aryl, or (CH2)n-aryl-(O—C1˜C16 alkyl)p, in which n is 0-15, p is 1-3; and m is 1, 2, 3, 4, or 5.Type: GrantFiled: January 24, 2002Date of Patent: November 15, 2005Assignee: Academia SinicaInventors: Kuang-Lieh Lu, Manimaran Bala, Thangamuthu Rajendran, Yi-Long Lu, Gene-Hsiang Lee, Shie-Ming Peng
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Patent number: 6951936Abstract: The invention provides a probe for detecting a highly ordered structural site of a nucleic acid of a gene by specifically binding with the structural site to generate an electrochemical response. The inventive probe comprises a cyclic ligand containing ferrocenyl group and a DNA threading intercalating moiety, such as 1,4,5,8-tetrasubstituted naphthalene, 9,10-disubstituted anthracene, and 1,5-disubstituted anthraquinone. Current of the cyclic ligand is not observed due to interaction such as stacking or so called charge transfer between ferrocenyl group and the DNA threading intercalating moiety in conventional electrolyte. The binding of the ligand with a highly ordered structural site of a single stranded nucleic acid, where nucleic base inserts between the cavity of cyclic ligand, inhibits the intramolecular interaction of the ligand to convert the ligand into its electrically active form, and as a result, current is observed.Type: GrantFiled: July 12, 2001Date of Patent: October 4, 2005Assignee: Kyushu UniversityInventor: Shigeori Takenaka
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Patent number: 6919139Abstract: The present invention is generally directed to electroluminescent Ir(III) compounds with phosphinoalkoxides and phenylpyridines or phenylpyrimidines, and devices that are made with the Ir(III) compounds.Type: GrantFiled: February 3, 2003Date of Patent: July 19, 2005Assignee: E. I. du Pont de Nemours and CompanyInventors: Vladimir Grushin, Viacheslav A. Petrov
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Patent number: 6919449Abstract: The present invention relates to a method for the preparation of cephalosporin antibiotic of the formula (II), which comprises hydrolyzing and halogenating the ester of formula (III) by photochemical irradiation in one pot using a halogenating agent in the absence or presence of a solvent, to produce compound of formula (I), activating the 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) using conventional activation agents gives compound of formula (IV), condensing the activated compound of the formula (IV) with 7-amino cephem derivative of the formula (V) to produce a compound of formula (VI), and cyclizing the compound of formula (VI) with thiourea to give cephalosporin compounds of the formula (II).Type: GrantFiled: September 18, 2002Date of Patent: July 19, 2005Assignee: Orchid Chemicals and Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Pratik Ramesh Sathe, Sivakumaran Sundaravadivelan, Praveen Nagesh Ganesh
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Patent number: 6914152Abstract: A method for producing biphenyl and its derivative comprising oxidatively coupling a benzene aromatic compound in the presence of a catalyst comprising a palladium salt, a copper salt, and a bidentate ligand compound capable of forming a complex with the palladium salt via the nitrogen atom and the oxygen atom in the molecule thereof in an atmosphere containing molecular oxygen. In particular, an improved method for selectively producing an asymmetrically substituted biphenyl derivative, such as a 2,3,3?,4?-biphenyltetracarboxylic acid tetraester, which comprises oxidatively coupling a substituted aromatic compound, such as a phthalic diester, in the presence of the catalyst in an atmosphere containing molecular oxygen without replenishing with a ligand.Type: GrantFiled: October 2, 2002Date of Patent: July 5, 2005Assignee: Ube Industries, Ltd.Inventors: Yasushi Yamamoto, Tetsuro Tsuji, Jun Haruta
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Patent number: 6914154Abstract: A production process, especially a continuous production process, for a biphenyltetracarboxylic acid tetraester characterized by carrying out, in parallel, a step of preliminarily mixing a phthalic acid diester and a palladium compound-containing catalyst to prepare a starting mixture, a step of continuously or intermittently supplying the starting mixture to a reactor, a step of conducting oxidative dimerization reaction of the phthalic acid diester in a temperature range of from 140° C. and lower than 250° C. while supplying molecular oxygen to the reactor to form a reaction mixture in the reactor, and a step of continuously or intermittently removing a portion of the reaction mixture from the reactor.Type: GrantFiled: August 12, 2003Date of Patent: July 5, 2005Assignee: Ube Industries, Ltd.Inventors: Yasushi Yamamoto, Tetsuro Tsuji, Jun Haruta, Kikuo Ataka, Noboru Kakeya
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Patent number: 6911551Abstract: The present invention relates to substituted boron or aluminum spiro compounds and their use in the electronic industry. The compounds of the invention are used as electron transport material, hole blocking material and/or as host material in organic electroluminescence and/or phosphorescence devices, as electron transport material in photocopiers, as electron acceptor or electron transport material in solar cells, as charge transport material in organic ICs (circuits) and in organic solid-state lasers or organic photodetectors.Type: GrantFiled: December 20, 2001Date of Patent: June 28, 2005Assignee: Covion Organic Semiconductors GmbHInventors: Philipp Stössel, Hubert Spreitzer, Heinrich Becker, Jacqueline Drott
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Patent number: 6906055Abstract: A cephem compound (particularly its crystal) represented by the formula [I], wherein X is CH3COOH, CH3CH2COOH or CH3CN, and n is 0 to 5, is useful as an antibacterial agent (particularly anti-MRSA agent) and shows superior quality such as high solid stability, possible long-term stable preservation and the like.Type: GrantFiled: August 10, 2001Date of Patent: June 14, 2005Assignee: Takeda Chemical Industries, Ltd.Inventors: Tomoyasu Ishikawa, Shohei Hashiguchi, Yuji Iizawa
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Patent number: 6894049Abstract: The present invention relates to platinum antitumor drugs. In particular, it relates to platinum complexes having formula Ia or Ib or a pharmaceutically acceptable salt thereof wherein: each A is independently an anion; each B is independently halo, hydroxy, carboxylate, carbamate or a carbonate ester, Z is a substituted 5- or 6-membered, heterocyclic moiety wherein at least one substituent sterically hinders access of the Pt atom to a DNA strand of a tumor cell, and wherein Z is other than pyridine; and X is NH3 or mono- or dialkyl substituted NH3. which are active against cancer cells and have improved aqueous solubility and activity.Type: GrantFiled: October 4, 2000Date of Patent: May 17, 2005Assignee: AnorMED, Inc.Inventors: Ernest S. Y. Wong, Christen M. Giandomenico
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Publication number: 20040258620Abstract: The invention relates to a novel class of ligands, complexes comprising such ligands and a metal ion, and adducts of these metal complexes and a macromolecule. Pharmaceutical compositions and methods of making and using the ligand-metal complexes are also described. The invention also relates to the use of macromolecular adducts for enhancement of diagnostic imaging. In particular, the invention relates to (ethylene)-(propylene)-triaminepentaacetic acid (EPTPA) derivatives, a process for their production, and their use for the production of pharmaceutical agents for NMR diagnosis or radiodiagnosis or radiotherapy.Type: ApplicationFiled: August 19, 2004Publication date: December 23, 2004Inventors: Lutz Lehmann, Ulrich Niedballa, Hannelore Niedballa, Johannes Platzek, Matthias Friebe, Christoph Hilger, Andre E Merbach, Eva Jakab Toth, Robert Ruloff, Sabrina Laus
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Patent number: 6824894Abstract: A metal coordination compound having a basic structure represented by formula: MLmL′n (1), wherein M is a metal atom of Ir, Pt, Rh or Pd; L and L′ are mutually different bidentate ligands; m is 1, 2 or 3; wherein at least one bidentate ligand has a partial structure formed by condensation via an alkylene group having 2-10 carbon atoms, is provided. In an electroluminescence device composed of one or a plurality of organic films disposed between a cathode and an anode, at least one layer is a luminescence layer which is formed by incorporating luminescence molecules constituting the metal coordination compound having a structure of the formula (1) described above as a guest material in a host material thereby to provide an electroluminescence device producing luminescence at high efficiency and stably keeping a high luminance for a long period.Type: GrantFiled: July 17, 2002Date of Patent: November 30, 2004Assignee: Canon Kabushiki KaishaInventors: Takao Takiguchi, Akira Tsuboyama, Shinjiro Okada, Jun Kamatani, Seishi Miura, Takashi Moriyama, Satoshi Igawa, Manabu Furugori, Hidemasa Mizutani
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Patent number: 6821646Abstract: A luminescence device that has an organic compound layer disposed between a pair of electrodes. This organic compound layer contains a metal coordination compound represented by the following formula (1) wherein M is Ir, Rh or Pd; n is 2 or 3; CyN is a substituted or unsubstituted cyclic group containing a nitrogen atom connected to M and capable of containing another nitrogen atom and/or sulfur atom; and CyC is a substituted or unsubstituted cyclic group containing a carbon atom connected to M and capable of containing a nitrogen atom and/or a sulfur atom.Type: GrantFiled: September 24, 2001Date of Patent: November 23, 2004Assignee: Canon Kabushiki KaishaInventors: Akira Tsuboyama, Hidemasa Mizutani, Shinjiro Okada, Takao Takiguchi, Seishi Miura, Takashi Moriyama, Satoshi Igawa, Jun Kamatani, Manabu Furugori
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Patent number: 6818586Abstract: The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same. The inventive catalysts are of the formula wherein: M is ruthenium or osmium; X and X1 are the same or different and are each independently an anionic ligand; L, L1′ and L2 are the same or different and are each independently a neutral electron donor ligand; and, R and R1 are each independently hydrogen or a substituent selected from the group consisting of C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl and silyl.Type: GrantFiled: June 14, 2002Date of Patent: November 16, 2004Assignees: Cymetech, LLP, California Institute of TechnologyInventors: Robert H. Grubbs, Melanie S. Sanford, Jason L. Moore, Jennifer A. Love, Tina M. Trnka
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Publication number: 20040212773Abstract: Complexes of organic ligands with a metal ion exhibit unique conformation and spectroscopic properties upon changes in oxidation state of the metal ion. The metal is a redox-active metal ion and may possess additional ligands bonded to it. The organic ligand has three “arms” that are linked together at a central atom; each arm contains atoms that may also coordinate to the metal ion. At least two of the arms possess chromophoric properties. At least one arm contains two different groups that may coordinate to the metal ion. In one oxidation state, a first atom binds to the metal. In a second oxidation state, a second atom binds to the metal. This change in coordination of the metal ion results in a rotation of one of the arms, which changes the orientation of another group, which inverses the orientation of the two chromophoric species with respect to one another.Type: ApplicationFiled: December 23, 2003Publication date: October 28, 2004Inventors: James W. Canary, Suffen Zahn
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Publication number: 20040192541Abstract: The invention relates to a catalyst component and a catalyst system for the preparation of high molecular weight ethylene or alpha-olefin homopolymers, ethylene-alpha-olefin copolymers, terpolymers or tetrapolymers, in a polymerization process, which is expediently effected in solution, at elevated temperature, preferably at least 80 DEG C. The catalyst system comprises a group 4-6 metal, preferably group 4 metal, a cyclic ligand (such as a cyclopentadienyl-type ligand), which forms a delocalized pi-bond with the metal M, a monohapto bonded 1,3-diaza-2-imino heterocyclic ligand (such as an iminoimidazolidine-type ligand) and anionic ligands and a catalyst activator coupound.Type: ApplicationFiled: March 23, 2004Publication date: September 30, 2004Inventor: Winfried Peter Kretschmer
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Patent number: 6783873Abstract: A metal coordination compound having a binuclear molecular structure represented by the following formula (1): wherein M1 and M2 independently denotes a metal atom selected from the group consisting of Ir, Pt, Rh, Pd, Ru and Os; P is a quadridentate ligand connected to M1 and M1; Q1 is a bidentate ligand connected to M1; Q2 is a bidentate ligand connected to M2; and n is 1 or 2.Type: GrantFiled: June 13, 2002Date of Patent: August 31, 2004Assignee: Canon Kabushiki KaishaInventors: Akira Tsuboyama, Hidemasa Mizutani, Shinjiro Okada, Takao Takiguchi, Seishi Miura, Takashi Moriyama, Satoshi Igawa, Jun Kamatani, Manabu Furugori
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Publication number: 20040116696Abstract: The present invention is generally directed to electroluminescent Ir(III) compounds, the substituted 2-phenylpyridines, phenylpyrimidines, and phenylquinolines that are used to make the Ir(III) compounds, and devices that are made with the Ir(III) compounds.Type: ApplicationFiled: November 24, 2003Publication date: June 17, 2004Inventors: Vladimir Grushin, Viacheslav A. Petrov, Ying Wang
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Patent number: 6743786Abstract: The invention provides methods for treating cancer and compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates useful for preparing the compounds.Type: GrantFiled: May 8, 2002Date of Patent: June 1, 2004Assignee: Parker Hughes InstituteInventors: Fatih M. Uckun, Yanhong Dong, Phalguni Gosh
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Publication number: 20040101892Abstract: Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.Type: ApplicationFiled: August 15, 2003Publication date: May 27, 2004Applicant: Affymetrix, INC.Inventors: Glenn H. McGall, Anthony D. Barone
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Publication number: 20040097724Abstract: An organometallic framework material is prepared by a process which comprises reacting a fluid mixture comprising a metal salt with at least one one at least bidentate organic compound capable of coordination to metal ions in the presence of at least one base and a solvent, where the solvent comprises at least one cyclic amide (lactam) and/or at least one cyclic ester (lactone).Type: ApplicationFiled: September 5, 2003Publication date: May 20, 2004Inventors: Ulrich Muller, Michael Hesse, Lisa Lobree, Markus Holzle, Jan-Dirk Arndt, Peter Rudolf
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Publication number: 20040054152Abstract: The invention provides low molecular weight or polymeric organic materials in which at least one hydrogen atom is replaced by a group of the formula (A) 1Type: ApplicationFiled: October 23, 2003Publication date: March 18, 2004Inventors: Klaus Meerholz, Michael Bayerl, Florian Bielefeldt, Thomas Braig, Markus Gross, David Muller, Oskar Nuyken, Hubert Spreitzer
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Publication number: 20040044208Abstract: This invention relates to high purity hydrogen ion buffers and in particular amino-organosulfonic acid zwitterionic compositions having low metal content. The concentration of any single metal in the composition is no greater than about 500 ppb, and ideally is less than about 20 ppb.Type: ApplicationFiled: August 29, 2002Publication date: March 4, 2004Applicant: Buffers & Biochemicals CorporationInventors: David Bow, Glenn Thomas Carroll
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Publication number: 20040029854Abstract: The invention relates to ligand complexes characterised by the presence of a piperazineNONOate residue with metal cations where the cations derive from a transition metal or zinc in a stable oxidation state. These complexes are nitric oxide donors and exert an endothelio-protective effect on the coronary district and stimulate re-endothelialization and angiogenesis processes. The invention comprises a preparation process and the therapeutic use of said compounds.Type: ApplicationFiled: April 23, 2003Publication date: February 12, 2004Inventors: Luigi Casella, Marina Ziche