Chalcogen Bonded Directly To Ring Carbon Of A 1,2-diazine Ring Patents (Class 544/239)
Plural chalcogens bonded directly (Class 544/240)
Halogen attached directly to the 1,2-diazine ring by nonionic bonding (Class 544/241)
  • Method for treating septic shock
    Publication number: 20030158201
    Abstract: Levosimendan, or (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile, which has been previously suggested for the treatment of congestive heart failure is useful in the treatment of septic shock.
    Type: Application
    Filed: March 24, 2003
    Publication date: August 21, 2003
    Inventors: Anders Oldner, Michael Wanecek, Eddie Weitzberg, Anders Rudehill
  • Aryl ether derivatives and processes for their preparation and herbicidal and desiccant compositions containing them
    Publication number: 20030130122
    Abstract: Substituted aryl ether derived compounds represented by the general structure (1) are described.
    Type: Application
    Filed: December 5, 2001
    Publication date: July 10, 2003
    Applicant: ISHIHARA SANGYO KAISHA, LTD.
    Inventors: Sandeep Gupta, Masamitsu Tsukamoto, Mark Read
  • 2-Phenyl-2h-pyridazine-3-ones
    Publication number: 20030130123
    Abstract: The invention relates to 2-phenyl-2H-pyridazin-3-ones of the general formula I 1
    Type: Application
    Filed: October 10, 2002
    Publication date: July 10, 2003
    Inventors: Michael Puhl, Thorsten Volk, Gerhard Hamprecht, Robert Reinhard, Ingo Sagasser, Cyrill Zagar, Karl-Otto Westphalen, Matthias Witschel, Helmut Walter
  • Water-soluble phenylpyridazine compounds and compositions containing the same
    Publication number: 20030119838
    Abstract: Compounds having the formula (1): 1
    Type: Application
    Filed: September 25, 2002
    Publication date: June 26, 2003
    Applicant: KOWA CO., LTD.
    Inventors: Yoshinori Kyotani, Tomoyuki Koshi, Hiromichi Shigyo, Hideo Yoshizaki, Takahiro Kitamura, Shunji Takemura, Kyoko Yasuoka, Junko Totsuka, Seiichi Sato
  • Phenylpyridazinones
    Publication number: 20030119673
    Abstract: The invention relates to novel phenylpyridazinones of the general formula (I) 1
    Type: Application
    Filed: September 30, 2002
    Publication date: June 26, 2003
    Inventors: Karl-Heinz Linker, Kurt Findeisen, Wilhelm Haas, Markus Dollinger, Hans-Joachim Santel
  • Benzocycloalkylenylamine derivatives as muscarinic receptor antagonists
    Publication number: 20030109524
    Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: 1
    Type: Application
    Filed: November 6, 2002
    Publication date: June 12, 2003
    Inventors: Robert James Weikert, Ann Marie Madera, Russell Stephen Stabler
  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Publication number: 20030105101
    Abstract: The present invention describes pyridazinone compounds which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important “housekeeping” enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti inflammatory drugs (NSAIDs).
    Type: Application
    Filed: December 6, 2002
    Publication date: June 5, 2003
    Inventor: Lawrence A. Black
  • Inhibitors of p38
    Publication number: 20030096817
    Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Application
    Filed: May 10, 2002
    Publication date: May 22, 2003
    Inventors: Jeremy Green, Scott L. Harbeson, John E. Cochran
  • Zwitterionic imides
    Publication number: 20030087151
    Abstract: Zwitterionic imide compounds are provided according to the formula: R1—SO2—N−—SO2—R2+, where R1 and R2+are any suitable groups. Typically R1 is a highly fluorinated alkane and R2+contains a quaternary ammonium group or a heteroatomic aromatic group having an cationic nitrogen, such as: pyridiniumyl, pyridaziniumyl, pyrimidiniumyl, pyraziniumyl, imidazoliumyl, pyrazoliumyl, thiazoliumyl, oxazoliumyl, or triazoliumyl. Zwitterionic liquids are provided, typically having melting points of less than 100 ° C. and typically having a solubility in water of less than 5% by weight.
    Type: Application
    Filed: October 25, 2001
    Publication date: May 8, 2003
    Applicant: 3M Innovative Properties Company
    Inventor: Steven Joseph Hamrock
  • PPARgamma modulators
    Publication number: 20030088103
    Abstract: Modulators of PPAR&ggr; activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
    Type: Application
    Filed: April 15, 2002
    Publication date: May 8, 2003
    Applicant: Tularik Inc.
    Inventors: Jonathan B. Houze, Lawrence R. McGee, Steven Marc Rubenstein
  • Adenosine A2A receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver
    Patent number: 6555545
    Abstract: Hepatic cirrhosis and fibrosis and fatty liver can be prevented and treated by administering to a subject in need thereof an effective amount of at least one adenosine A2A receptor antagonist or at least one adenosine uptake promotor.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: April 29, 2003
    Assignee: New York University
    Inventors: Bruce N. Cronstein, Edwin Chan
  • Phenylpyridazinones
    Patent number: 6551963
    Abstract: The invention relates to novel phenylpyridazinones of the general formula (I) in which R1, R2, R3, R4, R5 and R6 are each as defined in the description, to processes for their preparation, to their use as herbicides and to novel intermediates and processes for preparing them.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: April 22, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl-Heinz Linker, Kurt Findeisen, Wilhelm Haas, Markus Dollinger, Hans-Joachim Santel
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20030073693
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: August 2, 2002
    Publication date: April 17, 2003
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • 3-arylphenyl sulfide derivative and insecticide and miticide
    Publication number: 20030069242
    Abstract: 3-Arylphenyl sulfide derivatives represented by general formula (I): 1
    Type: Application
    Filed: April 15, 2002
    Publication date: April 10, 2003
    Applicant: KUMIAI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Keiji Toriyabe, Nobuo Takefuji, Minoru Itou, Tetsuya Hirade, Kiyotoshi Nishiyama, Mitsuharu Asahida, Yasunobu Maeda, Nobuhide Wada, Toyokazu Fujisawa, Hiroyuki Yano, Masaaki Komatsu, Osamu Tada
  • Photographic processing composition containing heterocycle combination and method of forming image
    Publication number: 20030054298
    Abstract: A photographic processing composition for silver halide color photographic lightsensitive material, comprising at least one compound represented by the formula (I):
    Type: Application
    Filed: March 29, 2002
    Publication date: March 20, 2003
    Applicant: FUJI PHOTO FILM CO., LTD.
    Inventors: Makoto Suzuki, Yasufumi Nakai, Yoshiharu Yabuki
  • Novel cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
    Publication number: 20030050314
    Abstract: There are described cycloalkyl derivatives of the formula (I)
    Type: Application
    Filed: May 10, 2002
    Publication date: March 13, 2003
    Applicant: Aventis Pharma S.A.
    Inventors: Volkmar Wehner, Jochen Knolle, Hans Ulrich Stilz, Jean-Francois Gourvest, Denis Carniato, Thomas Richard Gadek, Robert McDowell, Robert Maurice Pitti, Sarah Catherine Bodary
  • Pyrazinone inhibitors of fatty acid binding protein and method
    Publication number: 20030040516
    Abstract: aP2 inhibiting compounds are provided having the formula 1
    Type: Application
    Filed: July 12, 2002
    Publication date: February 27, 2003
    Inventors: Richard Sulsky, Jeffrey A. Robl
  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Patent number: 6525053
    Abstract: The present invention describes pyridazione compounds having the formula (I), which are cyclooxygenase (COX) inhibitors The compounds are selective inhibitors of cyclooxygenase-2-(COX-2), which is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1), which is an important “housekeeping” enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDS).
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: February 25, 2003
    Assignee: Abbott Laboratories
    Inventor: Lawrence A. Black
  • 1H-imidazo[4,5-d]pyridazin-7-one, and corresponding thiones as corticotropin releasing factor (CRF) receptor ligands
    Patent number: 6518271
    Abstract: Corticotropin releasing factor (CRF) antagonists of formula I: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: February 11, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Paul Joseph Gilligan, Rajagopal Bakthavatchalam
  • 3-arylphenyl sulfide derivative and insecticide and miticide
    Patent number: 6509354
    Abstract: 3-Arylphenyl sulfide derivatives represented by general formula (I): (wherein R is a C2-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group or the like, B0 to B2 and B3 are hydrogen atoms, halogen atoms, cyano groups, C1-C4 haloalkyl groups or the like, n is 0, 1 or 2, and Ar is a phenyl ring, a pyridine ring, a thiophene ring, a pyrazole ring or the like), and insecticides and miticides containing the 3-arylphenyl sulfide derivatives as an active ingredient.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: January 21, 2003
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Keiji Toriyabe, Nobuo Takefuji, Minoru Itou, Tetsuya Hirade, Kiyotoshi Nishiyama, Mitsuharu Asahida, Yasunobu Maeda, Nobuhide Wada, Toyokazu Fujisawa, Hiroyuki Yano, Masaaki Komatsu, Osamu Tada
  • Aryl sulfonamides and sulfamide derivatives and uses thereof
    Publication number: 20030013714
    Abstract: This invention is directed to novel aryl sulfonamide and sulfamide compounds which bind selectively to and inhibit the activity of the human Y5 receptor. This invention is also related to uses of these compounds for the treatment of feeding disorders such as obesity, anorexia nervosa, bulimia nervosa, and abnormal conditions such as sexual/reproductive disorders, depression, epileptic seizure, hypertension, cerebral hemorrhage, congestive heart failure or sleep disturbances and for the treatment of any disease in which antagonism of a Y5 receptor may be useful.
    Type: Application
    Filed: April 2, 2002
    Publication date: January 16, 2003
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: Imadul Islam, Daljit S. Dhanoa, John M. Finn, Ping Du, Charles Gluchowski, Yoon T. Jeon
  • Sulfonyl pyridazinone compounds useful as aldose reductase inhibitors
    Publication number: 20030004139
    Abstract: This invention relates to novel sulfonyl pyridazinone compounds useful as aldose reductase inhibitors in the treatment or prevention of certain complications arising from diabetes mellitus, pharmaceutical compositions comprising the sulfonyl pyridazinone, pharmaceutical compositions comprising a combination of the sulfonyl pyridazinone together with a second pharmaceutical agent, therapeutic methods comprising the administration of the sulfonyl pyridazinone compounds, therapeutic methods comprising the administration of the sulfonyl pyridazinone compounds in combination with a second pharmaceutical agent and compounds useful as intermediates for preparing the sulfonyl pyridazinone compounds of this invention.
    Type: Application
    Filed: February 26, 2002
    Publication date: January 2, 2003
    Inventors: William H. Martin, Banavara L. Mylari
  • Process for preparing pyridazin-3-on derivatives
    Patent number: 6500951
    Abstract: A pyridazin-3-on derivative of the formula (1): in which R2 is a hydrogen atom or a C1-C3 alkyl group, R3 is a hydrogen atom or a C1-C3 alkyl group, and Q is an optionally substituted phenyl group can be prepared at a high yield and high purity by ring closing a carboxylic acid derivative of the formula (2): in which R2, R3 and Q are the same as defined above, or its salt in the presence of a nitrogen-containing aromatic compound and a boron compound.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: December 31, 2002
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masao Yanagawa, Masahiko Mizuno, Yoshiaki Oda
  • Compounds useful as anti-inflammatory agents
    Patent number: 6492393
    Abstract: Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: December 10, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Steffen Breitfelder, Pier F. Cirillo, Ming-Hong Hao, Eugene R. Hickey, Rajiv Sharma, Sanxing Sun, Hidenori Takahashi
  • Cyano-indole serotonin-reuptake inhibitor compound
    Patent number: 6492366
    Abstract: A compound selected from those of formula (I): wherein: R1 and R2 each independently represent hydrogen or, alkyl, T1 and T2 each independently represent alkylene, G represents a heterocyclic group selected of formula (&agr;):  wherein: W1 to W5 and X1 to X4 are so defined in the description. Medicinal products containing the same are useful as serotonin-reuptake inhibitors.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: December 10, 2002
    Assignee: Les Laboratoires Servier
    Inventors: Gilbert Lavielle, Olivier Muller, Mark Millan, Didier Cussac, Anne Dekeyne
  • Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
    Publication number: 20020183324
    Abstract: The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I: 1
    Type: Application
    Filed: October 29, 2001
    Publication date: December 5, 2002
    Inventors: Irina C. Jacobson, Ruth R. Wexler, Suanne Nakajima, Mimi L. Quan, Shuaige Wang, Joanne M. Smallheer, Jennifer Qiao
  • Heterocyclyl-substituted benzoylcyclohexandiones, their preparation, and their use as herbicides
    Publication number: 20020173424
    Abstract: There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators.
    Type: Application
    Filed: August 30, 2001
    Publication date: November 21, 2002
    Inventors: Andreas van Almsick, Lothar Willms, Thomas Auler, Hermann Bieringer, Felix Thurwachter
  • Substituted (hetero) aryl compounds, process for their preparation, agents containing them and their use as safeners
    Patent number: 6482947
    Abstract: Compounds of the formula I and their salts, as defined in claim 1, are suitable as safeners for protecting crop plants against the phytotoxic side-effects of herbicides.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: November 19, 2002
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Xenia Holdgrün, Lothar Willms, Klaus Bauer, Klaus Trinks, Hermann Bieringer
  • Herbicidally active benzoylcyclohexanediones
    Publication number: 20020165095
    Abstract: There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators.
    Type: Application
    Filed: August 30, 2001
    Publication date: November 7, 2002
    Inventors: Thomas Seitz, Andreas van Almsick, Lothar Willms, Hermann Bieringer, Thomas Auler, Hubert Menne
  • Pyridazinone derivatives
    Patent number: 6475955
    Abstract: This invention provides pyridazinone derivatives encompassed by the following the formula: wherein, R1, R2, R3, R4, R5 and R7 represent a hydrogen atom and the like, and R6 represents a C1-C3 alkyl and the like. The pyridazinone derivatives have excellent herbicidal activity, therefore, they can be used as an active ingredient for herbicidal compositions and can be utilized in herbicidal method, which are also described.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: November 5, 2002
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Takashi Komori
  • Substituted benzene compounds, process for their preparation, and herbicidal and defoliant compositions containing them
    Publication number: 20020133007
    Abstract: Novel herbicidal and defoliant substituted aniline derived compounds represented by general structure (I) 1
    Type: Application
    Filed: August 16, 2001
    Publication date: September 19, 2002
    Applicant: ISK AMERICAS INCORPORATED
    Inventors: Sandeep Gupta, Shao-Yong Wu, Masamitsu Tsukamoto, David A. Pulman, Bai-Ping Ying
  • Cyclic amide compounds
    Patent number: 6448242
    Abstract: The invention relates to compounds represented by the following general formula (1): wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a lower alkylene group which may be substituted, or the like, Y is a single bond or the like; Z is a divalent residue of benzene which may be substituted, or the like, and m and n are independently an integer of 1 to 4, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.
    Type: Grant
    Filed: August 21, 2000
    Date of Patent: September 10, 2002
    Assignee: Kowa Co., Ltd.
    Inventors: Hiroyuki Ishiwata, Seiichi Sato, Mototsugu Kabeya, Soichi Oda, Yukio Hattori, Makoto Suda, Manabu Shibasaki, Hiroshi Nakao, Takao Nagoya
  • Novel pyridazine derivatives and medicines containing the same as effective ingredients
    Publication number: 20020123496
    Abstract: This invention relates to pyridazine derivatives represented by the formula (1): 1
    Type: Application
    Filed: November 30, 2001
    Publication date: September 5, 2002
    Applicant: Kowa Co., Ltd.
    Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Tomoyuki Koshi, Takahiro Kitamura, Tadaaki Ohgiya, Takayuki Matsuda, Yukiyoshi Yamazaki, Natsuyo Kumai, Kyoko Kotaki, Hideo Yoshizaki, Yuriko Habata
  • Arylalkylpyridazinones
    Publication number: 20020111356
    Abstract: Aralkylpyridazinone derivatives of the formula I 1
    Type: Application
    Filed: April 8, 2002
    Publication date: August 15, 2002
    Applicant: MERCK KGAA
    Inventors: Rochus Jonas, Michael Wolf, Norbert Beier
  • Pyridazine derivatives and drugs containing the same as the active ingredient
    Patent number: 6403586
    Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a lower alkoxyl group, a lower alkylthio group or a halogen atom; R2 represents H, a lower alkoxyl group, a lower alkylthio group or a halogen atom; R3 represents a lower alkyl or lower alkenyl group, which may be substituted by one or more OHs, CNs, lower cycloalkyl groups, (substituted) aromatic groups or (substituted) carbamoyl groups; R4 represents COOH, a lower alkoxycarbonyl group, a (substituted) carbamoyl group, a (substituted) amino group, or a (substituted) ureido group; and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: June 11, 2002
    Assignee: Kowa Co., Ltd.
    Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Hideo Yoshizaki, Tomoyuki Koshi, Takahiro Kitamura, Takayuki Matsuda, Soichi Oda, Yuriko Habata, Kyoko Kotaki
  • Arylalkylpyridazinones
    Patent number: 6399611
    Abstract: Aralkylpyridazinone derivatives of the formula I and their physiologically acceptable salts in which R1, R2, R3, R4, R5 and Q have the meanings indicated in claim 1, show inhibition of phosphodiesterase IV and can be employed for the treatment of inflammatory processes and of allergies, asthma and autoimmune disorders.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: June 4, 2002
    Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung
    Inventors: Rochus Jonas, Michael Wolf, Norbert Beier
  • Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them
    Publication number: 20020061887
    Abstract: The present invention relates to compounds of the formula I 1
    Type: Application
    Filed: November 28, 2001
    Publication date: May 23, 2002
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Ursula Schindler, Karl Schonafinger, Hartmut Strobel
  • p-(sulfonyl) aryl and heteroarylamines as anti-inflammatory agents
    Publication number: 20020052349
    Abstract: This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Application
    Filed: April 26, 2001
    Publication date: May 2, 2002
    Inventors: Nancy Elisabeth Krauss, Taraneh Mirzadegan, David Bernard Smith, Keith Adrian Walker
  • Methods and compositions controlling biofouling using sulfamic acids
    Patent number: 6380182
    Abstract: The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfamic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfamic acid used in the method of the invention has the formula R1R2NS(O)2(OH). In this formula, R1 and R2 are independently a hydrogen, a C4-C20 alkyl group or a cyclohexyl group. However, R1 and R 2 are not both hydrogen.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: April 30, 2002
    Inventors: Thomas E. McNeel, Marilyn S. Whittemore, Stephen D. Bryant, Graciela H. Vunk
  • New derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Publication number: 20020045753
    Abstract: A compound of the formula 1
    Type: Application
    Filed: September 4, 2001
    Publication date: April 18, 2002
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auguet, Jeremiah Harnett
  • Alpha-acyl- and alpha-heteroatom-substituted benzene acetamide glucokinase activators
    Publication number: 20020042512
    Abstract: Substituted benzene acetamide compounds which are glucokinase activators and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: July 13, 2001
    Publication date: April 11, 2002
    Inventors: Robert F. Kester, Ramakanth Sarabu
  • Compounds having activity as inhibitors of cytochrome P450RAI
    Patent number: 6369225
    Abstract: Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: April 9, 2002
    Assignee: Allergan Sales, Inc.
    Inventors: Jayasree Vasudevan, Alan T. Johnson, Dehua Huang, Roshantha A. Chandraratna
  • Aromatic compounds and pharmaceutical compositions containing them
    Patent number: 6365603
    Abstract: Compounds of formula I useful for inhibiting the pain enhancing effects of E-type prostaglandins are disclosed wherein A is a ring system in which the —CH(R3)N(R2)B—R1 and —OR4 groups are positioned in a 1,2 relationship to one another on ring carbon atoms. B is a ring system having R1 in a 1,3 or 1,4 relationship with the —CH(R1)N(R2)— linking group. A, B, R1, R2, R3 and R4 are as defined in the specification and may be substituted. Also disclosed are pharmaceutically-acceptable salts, in vivo-hydrolysable esters and amides of compounds of formula I, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and the use of such compounds as therapeutic agents.
    Type: Grant
    Filed: September 13, 1999
    Date of Patent: April 2, 2002
    Assignee: Zeneca Ltd.
    Inventor: Gloria Anne Breault
  • Substituted aryl hydroxamic acids as metalloproteinase inhibitors
    Patent number: 6365587
    Abstract: The present application describes novel substituted aryl hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring A is a 5-8 membered ring containing from 0-1 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: April 2, 2002
    Inventors: Matthew E. Voss, Carl P. Decicco, Ruth R. Wexler
  • Cycloalkenyl substituted compounds
    Patent number: 6362193
    Abstract: Novel pyridyl or pyrimidinyl substituted cycloalkenyl compounds and compositions for use in therapy.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: March 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Ravi Garigipati
  • ACETYLENES DISUBSTITUTED WITH A 5 ALKYL, ARYL OR HETEROARYL SUBSTITUTED DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUP HAVING RETINOID-LIKE WITH AN ARYL OR HETEROARYL GROUP HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY
    Patent number: 6355806
    Abstract: Compounds of the formula wherein the symbols have the meaning described in the specification, have retinoid-like biological activity.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: March 12, 2002
    Assignee: Allergen Sales, Inc.
    Inventors: Alan T. Johnson, Min Teng, Vidyasagar Vuligonda, Richard L. Beard, Samuel J. Gillett, Tien T. Duong, Roshantha A. Chandraratna
  • Oral compositions of levosimendan
    Patent number: 6355269
    Abstract: A composition for oral administration comprising a substantially pure crystalline polymorphic form (I) of levosimendan as an active ingredient together with a pharmaceutically acceptable carrier is described. Polymorphic form (I) of levosimendan is rapidly absorbed from the gastrointestinal tract and is useful in the treatment of congestive heart disease.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: March 12, 2002
    Assignee: Orion Corporation
    Inventors: Maarit Backman, Ilkka Larma, Saila Antila, Lasse Lehtonen
  • Aza compounds, pharmaceutical compositions and methods of use
    Publication number: 20020028814
    Abstract: The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.
    Type: Application
    Filed: April 17, 2001
    Publication date: March 7, 2002
    Inventors: Yong-Qian Wu, Wei Huang, Gregory S. Hamilton
  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Publication number: 20020028938
    Abstract: The present invention describes pyridazinone compounds of formula I 1
    Type: Application
    Filed: May 31, 2001
    Publication date: March 7, 2002
    Inventors: Lawrence A. Black, Anwer Basha, Teodozyj Kolasa, Michael E. Kort, Huaqing Liu, Catherine M. McCarty, Meena Patel, Jeffrey J. Rohde, Michael J. Coghlan, Andrew O. Stewart
  • Platelet ADP receptor inhibitors
    Publication number: 20020025961
    Abstract: Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 5, 2001
    Publication date: February 28, 2002
    Inventors: Robert M. Scarborough, Hans-Michael Jantzen, Wolin Huang, David M. Sedlock, Charles Marlowe