Plural Chalcogens Bonded Directly Patents (Class 544/240)
  • Patent number: 9029295
    Abstract: The present invention relates to a pyridazinone compound of the formula (I): wherein R1 represents hydrogen, a C1-6 alkyl group, and the like, R2 represents halogen, a cyano group, a nitro group, a C1-6 alkoxy group, and the like, G represents hydrogen, and the like, Z represents halogen, a cyano group, a nitro group, a C1-6 alkyl group, and the like, and n represents an integer of 1-5 useful as an active ingredient in a herbicide and a noxious arthropod controlling agent.
    Type: Grant
    Filed: December 26, 2011
    Date of Patent: May 12, 2015
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Takashi Kuragano, Shin-ichiro Souma, Yoshinobu Jin, Tomohiro Araki
  • Publication number: 20150126739
    Abstract: A pyridazinone compound represented by the formula (I) has excellent effect on weed control and is useful as an active ingredient of herbicides.
    Type: Application
    Filed: January 14, 2015
    Publication date: May 7, 2015
    Inventors: Toshiyuki KIJI, Takafumi FUSAKA
  • Publication number: 20150126738
    Abstract: A pyridazinone compound represented by the formula (I) has excellent effect on weed control and is useful as an active ingredient of herbicides.
    Type: Application
    Filed: January 14, 2015
    Publication date: May 7, 2015
    Inventors: Toshiyuki KIJI, Takafumi FUSAKA
  • Patent number: 8962625
    Abstract: A pyridazinone compound represented by the formula (I) has excellent effect on weed control and is useful as an active ingredient of herbicides.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: February 24, 2015
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toshiyuki Kiji, Takafumi Fusaka
  • Publication number: 20150030704
    Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: August 21, 2012
    Publication date: January 29, 2015
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: William Farnaby, Charlotte Fieldhouse, Katherine Hazel, Catrina Kerr, Natasha Kinsella, David Livermore, Kevin Merchant, David Miller
  • Publication number: 20140336165
    Abstract: Provided is a compound having a D-amino acid oxidase (DAAO) inhibitory action, and useful as, for example, a prophylaxis and/or therapeutic agent for schizophrenia or neuropathic pain. The present inventors have studied a compound that inhibits DAAO, and confirm that a dihydroxy aromatic heterocyclic compound has a DAAO inhibitory action, and completed the present invention. That is, the dihydroxy aromatic heterocyclic compound of the present invention has a good DAAO inhibitory action, and can be used as a prophylaxis and/or therapeutic agent for, for example, schizophrenia or neuropathic pain.
    Type: Application
    Filed: November 14, 2012
    Publication date: November 13, 2014
    Inventors: Takeshi Hondo, Keita Nakanishi, Tatsuya Niimi, Masaichi Warizaya, Ichiji Namatame, Katsuya Harada
  • Patent number: 8884010
    Abstract: The present invention relates to a novel method for producing a pyridazinone compound and an intermediate thereof as shown in the following scheme: wherein the symbols are as defined in the specification.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: November 11, 2014
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Markus Jachmann, Takayuki Wakamatsu, Mitsuharu Anryu
  • Publication number: 20140256546
    Abstract: The present invention provides a compound of Formula (I) or an agronomically acceptable salt thereof, wherein: R2 is selected from the group consisting of (A1), (A2) and (A3) wherein X1 is N or CR7X2 is N or CR8X3 is N or CR9X4 is N or CR6R1, R3, R4, R5 R6, R7, R8 and R9 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants.
    Type: Application
    Filed: October 3, 2011
    Publication date: September 11, 2014
    Applicant: SYNGENTA LIMITED
    Inventors: Yunas Bhonoah, Alison Clare Elliott, Steven Gaulier, Kenneth Ling, Glynn Mitchell, James Alan Morris, Paula Rocha Rzepa, Russell Colin Viner
  • Publication number: 20140256549
    Abstract: The present invention relates to esters of carboxylic acid agrochemicals comprising a labile protecting group and having formula (I). Certain of the esters of carboxylic acid agrochemicals do not undergo hydrolysis to a significant degree in the dark, but are cleaved to regenerate the parent carboxylic acid agrochemical when exposed to light. Others of the esters of carboxylic acid agrochemicals undergo hydrolysis under both light and dark conditions. The present invention further relates to methods for the controlled release of a carboxylic acid agrochemicals, and to methods of controlling unwanted plants comprising applying to the unwanted plants an ester of a carboxylic acid agrochemical.
    Type: Application
    Filed: October 11, 2012
    Publication date: September 11, 2014
    Applicant: MONSANTO TECHNOLOGY LLC
    Inventor: David A. Morgenstern
  • Patent number: 8686155
    Abstract: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: April 1, 2014
    Assignee: Amgen Inc.
    Inventors: Victor J. Cee, Philip R. Olivieri, Laurie Schenkel
  • Publication number: 20140024648
    Abstract: The invention relates to pyridazinone and pyridone compounds having formula (I) or (I?), and pharmaceutically acceptable salts, hydrates, and solvates thereof (I) wherein R1/R4 and X and X3 are as defined in the claims. The invention further relates to their use as inhibitors of copper-containing amine oxidases. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds, pharmaceutically acceptable salts, hydrates, or solvates thereof.
    Type: Application
    Filed: March 6, 2012
    Publication date: January 23, 2014
    Applicant: BIOTIE THERAPIES CORPORATION
    Inventors: Marjo Pihlavisto, David Smith, Auni Juhakoski, Ferenc Fulop, Laszlo Lazar, Istvan Szatmari, Ferenc Miklos, Zsolt Szakonyi, Lorand Kiss, Marta Palko
  • Publication number: 20130303541
    Abstract: The present invention discloses an aryloxy dihalopropenyl ether compound with the structure shown as general formula (I), of which the group definitions can be seen in the specification. The present invention also discloses the use of the compound with general formula (I) as an insecticide in the agricultural field and an insecticidal composition using the compound with general formula (I) as an active component.
    Type: Application
    Filed: March 28, 2012
    Publication date: November 14, 2013
    Applicants: Shenyang Research Institute Of Chemical Industry Co., Ltd., SINOCHEM CORPORATION
    Inventors: Changling Liu, Jichun Yang, Xiuhui Chang, Miao Li, KeKe Li, Qiao Wu, Yuquan Song
  • Publication number: 20130281299
    Abstract: The present invention relates to a pyridazinone compound of the formula (I): wherein R1 represents hydrogen, a C1-6 alkyl group, and the like, R2 represents halogen, a cyano group, a nitro group, a C1-6 alkoxy group, and the like, G represents hydrogen, and the like, Z represents halogen, a cyano group, a nitro group, a C1-6 alkyl group, and the like, and n represents an integer of 1-5 useful as an active ingredient in a herbicideand a noxious arthropod controlling agent.
    Type: Application
    Filed: December 26, 2011
    Publication date: October 24, 2013
    Applicant: SUMITOMO CHEMICAL COMPANY,LIMITED
    Inventors: Takashi Kuragano, Shin-ichiro Souma, Yoshinobu Jin, Tomohiro Araki
  • Publication number: 20130237515
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R1, R2, L1, L2, U and B are as defined in the application, which have valuable pharmacological properties, and in particular modulate the activity of the MCH receptor.
    Type: Application
    Filed: February 28, 2013
    Publication date: September 12, 2013
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Thorsten OOST, Ralf LOTZ, Dirk STENKAMP
  • Patent number: 8507410
    Abstract: A pyridazinone compound represented by formula (I) wherein R1 represents a C1-6 alkyl group or a (C1-6 alkyloxy) C1-6 alkyl group, R2 and R3 represent hydrogen or a C1-6 alkyl group, W represents halogen, etc., Z1 represents a C1-6 alkyl group, Z2 represents a C1-6 alkyl group, a C3-8 cycloalkyl group, etc., and n represents 0, 1, 2, 3 or 4, has a weed-controlling effect and an arthropod-controlling effect.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: August 13, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Takafumi Fusaka
  • Patent number: 8481537
    Abstract: The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: July 9, 2013
    Assignee: LG Life Sciences Ltd.
    Inventors: Hye Kyung Chang, Yeong Soo Oh, Yong Jin Jang
  • Publication number: 20130172556
    Abstract: The present invention relates to a novel method for producing a pyridazinone compound and an intermediate thereof as shown in the following scheme: wherein the symbols are as defined in the specification.
    Type: Application
    Filed: September 7, 2011
    Publication date: July 4, 2013
    Inventors: Markus Jachmann, Takayuki Wakamatsu, Mitsuharu Anryu
  • Patent number: 8470738
    Abstract: There is provided a compound represented by the formula (I): wherein R1 is a C1-6 alkyl group or a (C1-6 alkyloxy)C1-6 alkyl group; R2 is a hydrogen atom or a C1-6 alkyl group; G is a hydrogen atom etc.; Z1 is a C1-6 alkyl group or a C1-6 alkyloxy group; Z2 is a C3-8 cycloalkyl group, etc.; Z3 is a C1-6 alkyl group, etc.; n is 0, 1, 2 or 3, which has an excellent weed controlling effect.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: June 25, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Takafumi Fusaka
  • Publication number: 20130158021
    Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
    Type: Application
    Filed: October 26, 2012
    Publication date: June 20, 2013
    Applicant: Massachusetts Institute of Technology
    Inventor: Massachusetts Institute of Technology
  • Publication number: 20130157851
    Abstract: New phenylamidines are described, having general formula (I): and their use for the control of phytopathogenic fungi.
    Type: Application
    Filed: August 18, 2011
    Publication date: June 20, 2013
    Applicant: ISAGRO S.P.A.
    Inventors: Marilena Gusmeroli, Lucio Filippini, Franco Pellacini, Paolo Bravini, Alexia Elmini, Matteo Santino Vazzola, Christian Badaracco
  • Publication number: 20130131062
    Abstract: The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.
    Type: Application
    Filed: December 21, 2007
    Publication date: May 23, 2013
    Inventors: Hakim Djaballah, Harold E. Varmus, David Shum, Romel Somwar, Alexander Chucholowski, Mohan Santhanam Thiruvazhi
  • Publication number: 20130052281
    Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: August 22, 2012
    Publication date: February 28, 2013
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: William FARNABY, Charlotte FIELDHOUSE, Catrina KERR, Natasha KINSELLA, David LIVERMORE, Kevin MERCHANT, David MILLER, Katherine HAZEL
  • Publication number: 20120276006
    Abstract: The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.
    Type: Application
    Filed: June 21, 2012
    Publication date: November 1, 2012
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: David S. Casebier, Simon P. Robinson, Ajay Purohit, Heike S. Radeke, Michael T. Azure, Douglas D. Dischino
  • Publication number: 20120238740
    Abstract: The present invention provides novel and advantageous processes for preparing and purifying pharmaceuticals The processes comprise a nucleophilic reaction wherein a modified leaving group LM, which has increased lipophilicity, of a vector in a nucleophilic reaction which offers a convenient and time-saving way to purify the product from non-reacted precursors vector-LM and by-products LM.
    Type: Application
    Filed: July 6, 2010
    Publication date: September 20, 2012
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith Graham, Mathias Berndt, Dae Yoon Chi, Byoung Se Lee, Sandip S. Shinde, Hee Seup Kil, Sang Ju Lee, Jin-Sook Ryu, Seung Jun Oh
  • Publication number: 20120196750
    Abstract: A pyridazinone compound represented by the formula (I) has excellent effect on weed control and is useful as an active ingredient of herbicides.
    Type: Application
    Filed: March 22, 2012
    Publication date: August 2, 2012
    Inventors: Toshiyuki KIJI, Takafumi Fusaka
  • Publication number: 20120190124
    Abstract: The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1—H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X?, Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.
    Type: Application
    Filed: August 9, 2010
    Publication date: July 26, 2012
    Inventors: Mark Smith, Stephen Caddick, James Baker
  • Publication number: 20120190579
    Abstract: The present invention relates to a product comprising a solid substrate and a moiety of formula (I) linked thereto: wherein X, X? and R are as defined herein. The product is useful for immobilising target molecules such as molecules of biochemical interest to solid substrates for numerous applications, such as affinity chromatography, ELISA, biotechnological assay techniques and solid phase peptide synthesis.
    Type: Application
    Filed: August 9, 2010
    Publication date: July 26, 2012
    Applicant: UCL Business PLC
    Inventors: Mark Smith, Stephen Caddick, James Baker
  • Publication number: 20120184736
    Abstract: Disclosed is a method for producing a 3-(substituted oxy)-4-pyridazinol derivative represented by the general formula (I), which comprises reacting a compound represented by the general formula (III) with a compound represented by the general formula (IV) in the presence or absence of a base and in the presence or absence of a solvent. According to the present invention, a 3-(substituted oxy)-4-pyridazinol derivative represented by the general formula (I) can be produced in high yield and with high selectivity.
    Type: Application
    Filed: September 29, 2010
    Publication date: July 19, 2012
    Applicant: MITSUI CHEMICALS AGRO, INC
    Inventors: Hideaki Ikishima, Nobuhiro Kondo, Takeshi Takada, Yoshihisa Tsukamoto, Hidetake Yoshitomi, Haruko Mita
  • Publication number: 20120165339
    Abstract: A cyclopropane derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof has orexin receptor inhibitory action, and thus, is extremely useful as an agent for preventing or treating sleep disorder or dyssomnia caused by orexin, including insomnia as a typical example: wherein A1, A2 and A3 each independently represent an aryl group, a heterocyclyl group or the like, R1, R2 and R3 each independently represent a hydrogen atom, a C1-6 alkyl group or the like, X represents an oxygen atom or the like, and L represents a bond or the like.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 28, 2012
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Taro Terauchi, Ayumi Takemura, Yuji Kazuta, Fumihiro Ozaki, Takashi Doko, Yu Yoshida, Toshiaki Tanaka, Keiichi Sorimachi, Yoshimitsu Naoe, Carsten Beuckmann
  • Publication number: 20120149710
    Abstract: Bacterial infections, including Methicillin resistant Staphylococcus aureus (MRSA) infections are a major health problem that has created a pressing need for new antibiotics. Pyridazinone, rhodanine, and pyrazolethione compounds effective inhibit the enzymatic activity of sortase A (srtA) found in gram positive bacteria are disclosed. A structure activity relationship (SAR) analysis led to the identification of several pyridazinone and pyrazolethione analogs that inhibit SrtA with IC50 values in the sub-micromolar range. Compounds that inhibit the S. aureus SrtA sortase may function as potent anti-infective agents as this enzyme attaches virulence factors to the cell wall. Many of these molecules also inhibit the sortase enzyme from B. anthracis suggesting that they may be generalized sortase inhibitors. The novel compounds, compositions, uses, formulations, medicaments, articles of manufacture provide improved materials, uses, and treatments useful in combating infectious disorders.
    Type: Application
    Filed: August 23, 2010
    Publication date: June 14, 2012
    Inventors: Michael E. Jung, Robert T. Clubb, Sung Wook Yi, Nutee Suree, Jeremy Justin Clemens
  • Publication number: 20120028988
    Abstract: Since a pyridazinone compound shown by formula (I) has an activity for controlling arthropod pests, the pyridazinone compound is effective for a use for controlling arthropod pests.
    Type: Application
    Filed: March 24, 2010
    Publication date: February 2, 2012
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Norihisa Sakamoto, Takafumi Fusaka
  • Patent number: 8022221
    Abstract: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: September 20, 2011
    Assignee: Amgen Inc.
    Inventors: Victor J. Cee, Holly L. Deak, Bingfan Du, Stephanie D. Geuns-Meyer, Brian L. Hodous, Hanh Nho Nguyen, Philip R. Olivieri, Vinod F. Patel, Karina Romero, Laurie Schenkel
  • Publication number: 20110183998
    Abstract: Heterocyclic derivatives, processes for their preparation, medicaments comprising these compounds, and the use thereof. The invention relates to compounds of the formula I in which the radicals R1, R2, R3, R4, W, A, B, D, E, G, L, M, R, T and Y have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example for the treatment of the metabolic syndrome, insulin resistance, obesity and diabetes.
    Type: Application
    Filed: July 7, 2009
    Publication date: July 28, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Gerhard Zoller, Dieter Schmoll, Marco Mueller, Guido Haschke, Ingo Focken
  • Patent number: 7968711
    Abstract: The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular hypertension of a compound of formula I wherein Y, Q, Z, R, R1 and R2 are as defined in the specification. The present invention further comprises pharmaceutical compositions, e.g. ophthalmic compositions, including said compound.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: June 28, 2011
    Assignee: Allergan, Inc.
    Inventors: June Chen, Simon N. Pettit, Hans G. Fliri
  • Patent number: 7964531
    Abstract: A compound represented by the formula: [wherein R1 represents a hydrogen atom, a halogen atom, alkyl group, etc., R2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R3, R4, R5, R6 and R7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substitutable cycloalkyl group, etc., or R3, R4, R5, R6 and R7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: June 21, 2011
    Assignee: Mitsui Chemicals Agro, Inc.
    Inventors: Yoshihisa Tsukamoto, Hiroyuki Komai, Junji Kadotani, Kiyoshi Koi, Shigeru Mio, Hideo Takeshiba
  • Publication number: 20110118118
    Abstract: Phenyl-substituted pyridazinones of the formula (I) are described as herbicides and insecticides. In this formula (I), A, B, G, X, Y and Z represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen, nitro and cyano.
    Type: Application
    Filed: September 23, 2010
    Publication date: May 19, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Stefan Lehr, Jan Dittgen, Christopher Hugh Rosinger, Dieter Feucht, Isolde Häuser-Hahn
  • Patent number: 7906644
    Abstract: The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: March 15, 2011
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Ankush Argade, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li
  • Publication number: 20110003692
    Abstract: The invention describes phenyl-substituted pyridazinones of the formula (I) as herbicides and insecticides. In this formula (I), A, B, G, X, Y and Z are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen, nitro and cyano.
    Type: Application
    Filed: December 14, 2009
    Publication date: January 6, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Stefan Lehr, Thomas Schenke, Christopher Hugh Rosinger, Reiner Fischer, Isolde Häuser-Hahn, Dieter Feucht, Jan Dittgen, Pierre Cristau, Oliver Gaertzen, Stefan Herrmann, Olga Malsam, Eva-Maria Franken
  • Publication number: 20100286390
    Abstract: Novel pyridazinone compounds of formula (I), which inhibit the purinergic P2X7 receptor and are useful for prevention, therapy and improvement of inflammatory and immunological diseases.
    Type: Application
    Filed: October 30, 2008
    Publication date: November 11, 2010
    Inventors: Yukihiro Shigeta, Yutaka Hirokawa, Hiroshi Nagai, Kei Nagae, Tsuneo Watanabe, Megumi Io, Yusuke Shintani, Junji Kamon, Masato Horikawa, Kazuya Takeuchi
  • Patent number: 7816357
    Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I. including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R4, R5, m and n are described herein.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: October 19, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guixue Yu, William R. Ewing, Amarendra B. Mikkilineni, Annapurna Pendri, Bruce A. Ellsworth, Philip M. Sher, Samuel Gerritz, Chongqing Sun, Natesan Murugesan, Ximao Wu
  • Publication number: 20100216642
    Abstract: There is provided a compound represented by the formula (I): wherein R1 is a C1-6 alkyl group or a (C1-6 alkyloxy)C1-6 alkyl group; R2 is a hydrogen atom or a C1-6 alkyl group; G is a hydrogen atom etc.; Z1 is a C1-6 alkyl group or a C1-6 alkyloxy group; Z2 is a C3-8 cycloalkyl group, etc.; Z3 is a C1-6 alkyl group, etc.; n is 0, 1, 2 or 3, which has an excellent weed controlling effect.
    Type: Application
    Filed: September 12, 2008
    Publication date: August 26, 2010
    Applicant: SUMITOMO CHEMICAL COMPANY LIMITED
    Inventor: Takafumi Fusaka
  • Publication number: 20100210649
    Abstract: The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.
    Type: Application
    Filed: December 21, 2007
    Publication date: August 19, 2010
    Applicant: Sloan-Kettering Institute for Cancer Research
    Inventors: Hakim Djaballah, Harold E. Varmus, David Shum, Romel Somwar, Alexander Chucholowski, Mohan Santhanam Thiruvazhi
  • Patent number: 7767811
    Abstract: One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomeric mixture of a chiral substrate, e.g., a cyclic carbonate or cyclic carbamate; and a nucleophile, e.g., an alcohol, amine or thiol. A preferred embodiment of the present invention relates to a method for achieving the kinetic resolution of racemic and diastereomeric mixtures of derivatives of ?- and ?-amino, hydroxy, and thio carboxylic acids. In certain embodiments, the methods of the present invention achieve dynamic kinetic resolution of a racemic or diastereomeric mixture of a substrate, i.e.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: August 3, 2010
    Assignee: Brandeis University
    Inventors: Li Deng, Jianfeng Hang, Liang Tang
  • Publication number: 20100184602
    Abstract: The invention describes phenyl-substituted pyridazinones of the formula (I) as herbicides and insecticides. In this formula (I), A, B, G, X, Y and Z are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen, nitro and cyano.
    Type: Application
    Filed: December 15, 2009
    Publication date: July 22, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Stefan Lehr, Thomas Schenke, Christopher Hugh Rosinger, Reiner Fischer, Isolde Häuser-Hahn, Dieter Feucht, Jan Dittgen, Pierre Cristau, Oliver Gaertzen, Stefan Herrmann, Olga Malsam, Eva-Maria Franken
  • Publication number: 20100173775
    Abstract: The invention describes phenyl-substituted pyridazinones of the formula (I) as herbicides and insecticides. In this formula (I), A, B, G, X, Y and Z are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen, nitro and cyano.
    Type: Application
    Filed: December 15, 2009
    Publication date: July 8, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Stefan LEHR, Thomas Schenke, Christopher Hugh Rosinger, Reiner Fischer, Isolde Häuser-Hahn, Dieter Feucht, Jan Dittgen, Pierre Cristau, Oliver Gaertzen, Stefan Herrmann, Olga Malsam, Eva-Maria Franken
  • Publication number: 20100041555
    Abstract: A compound represented by the formula: [wherein R1 represents a hydrogen atom, a halogen atom, alkyl group, etc., R2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R3, R4, R5, R6 and R7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substitutable cycloalkyl group, etc., or R3, R4, R5, R6 and R7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.
    Type: Application
    Filed: August 18, 2009
    Publication date: February 18, 2010
    Applicant: MITSUI CHEMICALS AGRO, INC.
    Inventors: Yoshihisa Tsukamoto, Hiroyuki Komai, Junji Kadotani, Kiyoshi Koi, Shigeru Mio, Hideo Takeshiba
  • Publication number: 20100022526
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in claim 1, which are useful as fungicides.
    Type: Application
    Filed: January 21, 2008
    Publication date: January 28, 2010
    Applicant: SYNGENTA CROP PROTECTION, INC.
    Inventors: Clemens Lamberth, Sebastian Volker Wendeborn, Stephan Trah, Raphael Dumeunier
  • Patent number: 7642303
    Abstract: Thermoplastic composition and articles containing UV absorbers that protect the articles contents from harmful UV radiation are disclosed as well as methods for making the thermoplastic articles and methods for using the articles to contain and protect materials sensitive to UV radiation. The UV absorbers contain oxazolone and/or azine functional groups that absorb UV radiation and prevent its transmission into the article. Many of the compounds are novel compositions of matter. The generally clear thermoplastic articles of this disclosure are particularly useful for containing a variety of UV sensitive consumer products that would otherwise have to be packaged in opaque containers.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: January 5, 2010
    Inventors: Thomas L. Shakely, James John Krutak
  • Patent number: 7608563
    Abstract: A compound represented by the formula: [wherein R1 represents a hydrogen atom, a halogen, atom, alkyl group, etc., R2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R3, R4, R5, R6 and R7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substituteable cycloalkyl group, etc., or R3, R4, R5, R6 and R7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: October 27, 2009
    Assignee: Mitsui Agro Chemicals, Inc.
    Inventors: Yoshihisa Tsukamoto, Hiroyuki Komai, Junji Kadotani, Kiyoshi Koi, Shigeru Mio, Hideo Takeshiba
  • Patent number: RE44613
    Abstract: The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: November 26, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Kevin J. Duffy, William Henry Miller, Andrea K. Myers, Antony N. Shaw, Michael N. Zimmerman