Abstract: New substituted [3,6-pyridazinediylbis(thio)]bis-[2,2-dimethylalkanoic acids] and derivatives which are useful as anti-arteriosclerotic agents are disclosed. These compounds elevate the high density lipoprotein fraction of cholesterol, and also lower the low density lipoprotein fraction of cholesterol.

Abstract: Substituted pyridazones of the general formula ##STR1## where R.sup.2 is halogen or alkoxy, R.sup.1 is amino, alkylamino, dialkylamino, alkoxyamino, alkylalkoxyamino, halogen, alkoxy, trimethyleneimino or acylated amino, X is unsubstituted or substituted phenoxy of the formula ##STR2## where R.sup.3, R.sup.4 and R.sup.5 are each, independently of one another, hydrogen, halogen, nitro, cyano, carboxyl, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylmercapto, haloalkylmercapto, alkylsulfinyl or alkylsulfonyl and Y is hydrogen, cyano, haloalkyl, halogen or nitro, and herbicides which contain these compounds.

Abstract: A carbamylbiuret-modified polyisocyanate of the formula: ##STR1## wherein n is an integer of from about 1 to about 20; R is a divalent radical containing from about 1 to about 18 carbon atoms; and Y is a divalent radical selected from the group consisting of: ##STR2## wherein D is selected from the group consisting of O, S, and NH; X, X', and X" are independently selected from the group consisting of oxygen and sulfur; R.sup.2 and R.sup.3 are independently selected from the group consisting of aryl of from about 6 to about 18 carbon atoms, alkyl containing from about 1 to about 6 carbon atoms, and cycloalkyl containing from about 3 to about 7 carbon atoms, provided that each of R.sup.2 and R.sup.3 differs from R; and R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are independently selected from the group consisting of hydrogen, alkyl containing from about 1 to about 6 carbon atoms, cycloalkyl containing from about 3 to about 7 carbon atoms, phenyl, and benzyl.

Abstract: Heterocyclic sulfenamides, such as N-[2-chloro-5-(trifluoromethyl)phenyl]-N-[2,4-dinitro-6-trifluoromethyl)ph enyl]-3-nitro-2-pyridinesulfenamide, are useful as miticides, insecticides, fungicides and ovicides.

Abstract: Valuable pyridazinone intermediates to pharmaceutically useful compounds can be prepared in surprisingly high yields by the quinoline catalyzed reaction of the corresponding monohydrazone with an appropriately substituted acetic acid ester. In an especially preferred embodiment, p,p'-dichlorobenzil monohydrazone and methyl acetoacetate are reacted in a xylene solvent in the presence of quinoline to afford 4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one, which can then be reacted with ethylene carbonate in the presence of potassium carbonate to afford the antihypertensive agent, 4-acetyl-5,6-bis(p-chlorophenyl)-2-(2'-hydroxyethyl)-2H-pyridazin-3-one.

Abstract: A new heterocyclic chemical compound useful in the field of agricultural applications and in that of coloring substances has the formula ##STR1## (6-phenyl-[1,2,3]-oxadiazolo-(4,5 d)-pyridazine-7(6H)-one).

Abstract: Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 denotes hydrogen or an optionally substituted hydrocarbon radical of aliphatic character, and their salts are useful as peripheral analgetics and/or as antiphlogistic uricosuric and/or thrombolytic agents.

Abstract: A novel class of growth regulator compounds of the structural formula ##STR1## is disclosed, in which Y is --COOH or an agriculturally acceptable salt thereof, --COOR, --CH.sub.2 OH, --CHO, --R, --OR or halogen and R is C.sub.1 to C.sub.4 alkyl or alkenyl.

Abstract: The compounds are sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines which are useful to produce inhibition of histamine H-2 receptors.

Abstract: Pyridazones are prepared by heating 4,5-dihydro-3-pyridazones in the liquid phase in the presence of a dehydrogenation catalyst. The reaction temperature is in the range of from 150.degree. to 350.degree. C. The dehydrogenation catalyst contains a noble metal of subgroup 8 of the periodic table, which is generally supported on a carrier. The reaction is preferably carried out in the presence of a solvent.

Abstract: Compounds of the formula ##STR1## are useful antihypertensive agents.

Abstract: In a process for obtaining 4,5-dichloro-2-phenyl-3(2H)-pyridazinone from 5-chloro-4-amino-2-phenyl-3(2H)-pyridazinone the 5-chloro-4-amino-2-phenyl-3(2H)-pyridazinone is diazotized in a first stage in accordance with the following reaction: ##STR1## the compound (I) being obtained by dilution with water and filtration. In a second stage of the process the compound (I) is reacted with thionyl chloride in accordance with the following reaction: ##STR2## the 4,5-dichloro-2-phenyl-3(2H)-pyridazinone being obtained by dilution with water and filtration.

Abstract: Compounds of the formula I ##STR1## in which R.sub.1 and R.sub.2 each represent a hydrogen atom, a halogen atom, an alkyl group containing 1 to 3 carbon atoms, an alkoxy group containing 1 to 3 carbon atoms or a trifluoromethyl group; and R.sub.3 represents an alkyl group containing 1 to 4 carbon atoms mono- or polyhydroxyl substituted, the alcohol functions being unesterified or esterified by benzoic acid are useful as in therapy as medicaments, in particular as psychotropic and anorexigenic agents.

Abstract: The present invention provides new pyridazinones of the formula ##STR1## where R is alkyl;R.sub.1 and R.sub.2 are halo, alkyl, alkoxy, amino; nitro or trifluoromethyl;R.sub.3 is hydrogen, hydroxy, or acyloxy;R.sub.4 is hydrogen or alkyl; andR.sub.5 is hydroxy or acyl;which are useful as central nervous system depressants.

Abstract: O-alkyl-O-[1-(trifluoromethylphenyl)-1,6-dihydropyridaz-(6)-on-(3)-yl]-(thi ono)phosphoric(phosphonic) acid esters and ester-amides of the formula ##STR1## in which R is alkyl with 1 to 6 carbon atoms,R' is phenyl, alkyl with 1 to 4 carbon atoms, alkoxy with 1 to 6 carbon atoms, alkylthio with 1 to 6 carbon atoms or alkylamino with 1 to 4 carbon atoms in each alkyl chain,R" and R"' each independently is hydrogen or methyl, andR.sup.iv is hydrogen, halogen, nitro or halogenoalkyl with 1 to 3 carbon atoms,N is an integer from 1 to 4, andX is oxygen or sulfur,Which possess insecticidal and acaricidal properties.

Abstract: 1-Phenyl-1,6-dihydropyridaz-6-on-3-yl-(thiono)-phosphoric(phosphonic) acid esters of the formula ##STR1## in which R is alkyl,R.sup.1 is alkyl or alkoxy,R.sup.2 is halogenoalkyl, andX and Y each independently is oxygen or sulphur,Which possess arthropodicidal properties.

Abstract: O-Alkyl-O-[1,6-dihydro-1-substituted-6-thioxopyridazin(3)yl]-(thiono) (thiol) phosphoric (phosphonic) acid esters and ester-amides of the formula ##STR1## in which R is alkyl with 1 to 6 carbon atoms,R' is alkyl, alkoxy, alkylmercapto or alkylamino with 1 to 6 carbon atoms per alkyl chain, or phenyl,R" is alkyl, cyanoalkyl, carbalkoxyalkyl or alkylcarbonylalkyl with 1 to 4 carbon atoms per alkyl chain, phenyl or phenyl carrying at least one substituent selected from the group consisting of halogen, nitro, alkyl with 1 to 4 carbon atoms and halogenoalkyl with 1 to 4 carbon atoms, andX is oxygen or sulfur,Which possess arthropodicidal properties.

Abstract: This invention concerns novel aminoalkylthiopyridazine compounds useful for inhibiting the aggregation of blood platelets in animals and a process for preparing the compounds from an isothiuronium salt generated in situ from an aminoalkyl halide and thiourea. The compounds also have fungicidal and nematocidal properties.

Abstract: O-Alkyl-S-[1,6-dihydro-6-oxo-pyridazin(1)ylmethyl]-(thiono)-(di)-thiolphosp horic(phosphonic) acid esters of the formula ##STR1## in which R.sub.1 is alkyl or alkoxyalkyl with 1 to 6 carbon atoms per alkyl chain,R.sub.2 is alkyl, alkylmercapto, alkylamino or alkenylamino with up to 6 carbon atoms per aliphatic chain, amino or phenyl, andR.sub.3 is alkoxy, cyanoalkoxy, carbalkoxy-alkoxy, alkenyloxy, alkynyloxy, alkanoyloxy, dialkylcarbamoyloxy or alkylsulfonyloxy with up to 5 carbon atoms in each aliphatic chain, halogen, hydroxyl, or a (thiono) (thiol)-phosphoric(phosphonic) acid ester or esteramide radical,R.sub.4 and R.sub.5 each independently is hydrogen, alkyl with 1 to 3 carbon atoms or halogen, or R.sub.4 and R.sub.5 conjointly form a fused benzene ring, andX is oxygen or sulfur,Which possess insecticidal, acaricidal and nematocidal properties.

Abstract: O,O-Di-alkyl-O-(1-6-pyridazinon-3-yl)-(thiono)-phosphoric acid esters of the formula ##STR1## in which R is methyl or ethyl,R.sub.1 is alkyl with 3 to 5 carbon atoms or alkoxyalkyl with 1 to 3 carbon atoms in each alkoxy and alkyl moiety,R.sub.2 is hydrogen, nitro, halogen or alkyl with 1 to 6 carbon atoms, andX is oxygen or sulfur,Which possess insecticidal and acaricidal properties.

Abstract: O-?1-substituted-6-pyridazinon(3)yl!-thionoalkanephosphonic acid esters of the formula ##STR1## in which R.sub.1 and R.sub.2 each independently is alkyl with 1 to 7 carbon atoms,R.sub.3 is alkyl, cyanoalkyl, alkylcarbonylalkyl, carbalkoxyalkyl, hydroxyalkyl, alkylthioalkyl or halogenalkyl with 1 to 4 carbon atoms per alkyl radical, alkenyl or alkynyl with 3 to 5 carbon atoms, benzyl, benzyl carrying at least one substituent selected from halogen and alkyl with 1 to 3 carbon atoms, phenyl, phenyl carrying at least one substituent selected from nitro, halogen, alkyl with 1 to 3 carbon atoms and carbalkoxy with 1 to 4 carbon atoms, morpholinomethyl or piperidinomethyl,R.sub.4 and R.sub.5 each independently is hydrogen or alkyl with 1 to 3 carbon atoms, andX and Y each independently is oxygen or sulfur,Which possess insecticidal and acaricidal properties.

Abstract: O-Alkyl-S-?1,6-dihydro-6-thioxo-pyridazin-(1)-yl methyl!-(thiono)-(di)-thiol-phosphoric (phosphonic) acid esters and ester-amides of the formula ##STR1## in which R is alkyl with 1 to 6 carbon atoms,R.sup.1 is alkyl, alkoxy, alkylmercapto or alkylamino with a maximum of 6 carbon atoms per alkyl chain,R.sup.2 is halogen, alkoxy with 1 to 5 carbon atoms or alkyl with 1 to 5 carbon atoms,R.sup.3 and R.sup.4 each is hydrogen or conjointly form a fused benzene ring, andX is oxygen or sulfur atomWhich possess nematicidal and arthropodicidal, e.g. insecticidal and acaricidal properties.