Ring Nitrogen Is Shared By Two Cyclos Patents (Class 544/263)
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Publication number: 20030045532Abstract: A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-&agr;]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an amino moiety at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or ◯subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.Type: ApplicationFiled: June 14, 2002Publication date: March 6, 2003Inventors: Mark Stuart Chambers, Ian James Collins, Simon Charles Goodacre, David James Hallett, Philip Jones, Linda Elizabeth Keown, Robert James Maxey, Leslie Joseph Street
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Patent number: 6525056Abstract: Corticotropin releasing factor (CRF) antagonists of Formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.Type: GrantFiled: February 21, 2001Date of Patent: February 25, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Argyrios G. Arvanitis, Paul J. Gilligan, James P. Beck, Rajagopal Bakthavatchalam
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Patent number: 6521628Abstract: The invention relates to a novel fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent together with, and synergistically effective amounts of (a) at least one benzophenone of formula I wherein R1, R2, R3, R4, R5, R6, R7, m and n have the meaning given; at least one fungicidal active ingredient selected from the following groups (A), (B), (C), (D) and (E): (A) an ergosterol biosynthesis inhibitor; (B) a strobilurine derivative, (C) a melanin biosynthesis inhibitor; (D) a compound selected from the group consisting of acibenzolar, benomyl, captan, carboxin, chlorothalonil, copper, cyprodinil, dinocap, dithianon, dimethomorph, dodine, ethirimol, famoxadone, fenpiclonil, fluazinam, mancozeb, metalaxyl, pyrifenox, sulfur, vinclozolin and (E) an azolopyrimidine of formula II in which R8, R9, R10, R11, A, L and p have the meaning given; and to a method of controlling the growth of phytopathogenic fungi at a locus which comprises aType: GrantFiled: January 27, 2000Date of Patent: February 18, 2003Assignee: BASF AktiengesellschaftInventors: Henry Van Tuyl Cotter, Gunter Reichert, Ewald Sieverding, Petrus Martinus Franciscus Emanuel Jegerings
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Patent number: 6518222Abstract: N-(Triazoloazinyl)thiophenesulfonamide compounds were prepared from appropriately substituted 2-amino[1,2,4]triazolo[1,5-c]pyrimidine, 2-amino[1,2,4]triazolo[1,5-a]pyrimidine and 2-amino[1,2,4]triazolo[1,5-a]pyridine compounds and appropriately substituted thiophenesulfonyl chloride compounds. The compounds were found to be useful as herbicides.Type: GrantFiled: November 2, 2001Date of Patent: February 11, 2003Assignee: Dow AgroSciences LLCInventors: Kim Eric Arndt, Timothy Calvin Johnson, David George Ouse
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Patent number: 6518275Abstract: Fungicidal compositions comprising an acceptable carrier and/or surface active agent and synergistically effective amounts of (a) at least one azolopyrimidine of formula I in which R1, R2, L1, L2 and L3 have the meaning given in claim 1; and (b) at least one fungicidal active ingredient selected from benomyl, carboxin, captan, chlorothalonil, copper oxychloride, cyprodinil, dimethomorph, dithianon, dodine, famoxadone, fenhexamid, fenpiclonil, fenpropimorph, fluazinam, mancozeb, metalaxyl, pyrimethanil, quinoxifen, sulfur, triforine, vinclozolin, a fungicidal triazole derivative, and a synthetic strobilurine derivative. The invention also provides a method of controlling the growth of phytopathogenic fungi at a locus by applying synergistically effective amounts of at least one azolopyrimidine of formula I and at least one fungicidal active ingredient (b) to the locus.Type: GrantFiled: March 15, 2001Date of Patent: February 11, 2003Assignee: BASF AktiengesellschaftInventors: Henry Van Tuyl Cotter, Leslie May, Gunter Reichert, Ewald Sieverding
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Patent number: 6479666Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).Type: GrantFiled: May 23, 2001Date of Patent: November 12, 2002Assignee: Hoffman-La Roche Inc.Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley
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Publication number: 20020151713Abstract: This invention relates to compounds of the formula 1Type: ApplicationFiled: May 30, 2002Publication date: October 17, 2002Applicant: Pfizer Inc.Inventor: Yuhpyng L. Chen
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Publication number: 20020147338Abstract: The present invention relates to pyrazolotriazines according to formula (I) 1Type: ApplicationFiled: November 21, 2001Publication date: October 10, 2002Inventors: Paul J. Gilligan, Richard G. Wilde
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Publication number: 20020111361Abstract: N-(5,7-dimethoxy[1,2,4]triazolo[1,5-a]pyrimidin-2-yl) arylsulfonamide compounds were prepared from 2-amino-5,7-dimethoxy[1,2,4]triazolopyrimidine and appropriately substituted benzenesulfonyl chloride and pyridinesulfonyl chloride compounds. The compounds were found to be useful as herbicides.Type: ApplicationFiled: November 2, 2001Publication date: August 15, 2002Inventors: Timothy Calvin Johnson, John Cord VanHeertun, David George Ouse, Kim Eric Arndt, Mark Ardrew Pobanz, David Keith Walker
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Patent number: 6433169Abstract: 2-Alkoxy-6-trifluoromethyl-N-([1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamides are prepared by introducing the 2-alkoxy substituent of the benzenesulfonamide ring in the last step by contacting the corresponding 2-fluoro substituted material with the appropriate alkoxide.Type: GrantFiled: September 24, 2001Date of Patent: August 13, 2002Assignee: Dow AgroSciences LLCInventors: Michael Allen Gonzalez, Eric Wayne Otterbacher
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Publication number: 20020094935Abstract: N-(Triazoloazinyl)thiophenesulfonamide compounds were prepared from appropriately substituted 2-amino[1,2,4]triazolo[1,5-c]pyrimidine, 2-amino[1,2,4]triazolo[1,5-a]pyrimidine and 2-amino[1,2,4]triazolo[1,5-a]pyridine compounds and appropriately substituted thiophenesulfonyl chloride compounds. The compounds were found to be useful as herbicides.Type: ApplicationFiled: November 2, 2001Publication date: July 18, 2002Inventors: Kim Eric Arndt, Timothy Calvin Johnson, David George Ouse
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Patent number: 6380202Abstract: The novel compounds of formula I: wherein (R1, R2, Hal and L1 through L5 are defined in the specification) show selective fungicidal activity and high systemicity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.Type: GrantFiled: September 24, 1999Date of Patent: April 30, 2002Assignee: BASF AktiengesellschaftInventors: Klaus-Juergen Pees, Annerose Rehnig, Guido Albert
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Patent number: 6372743Abstract: Disclosed are compounds of the formula: where R1, R2, R3, R4, R5, R6, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.Type: GrantFiled: September 29, 2000Date of Patent: April 16, 2002Assignees: Neurogen Corporation, Pfizer Inc.Inventors: James W. Darrow, Stephane De Lombaert, Charles Blum, Jennifer Tran, Mark Giangiordano, David Andrew Griffith, Philip Albert Carpino
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Publication number: 20020037811Abstract: 2-Alkoxy-6-trifluoromethyl-N-([1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamides are prepared by introducing the 2-alkoxy substituent of the benzenesulfonamide ring in the last step by contacting the corresponding 2-fluoro substituted material with the appropriate alkoxide.Type: ApplicationFiled: September 24, 2001Publication date: March 28, 2002Inventors: Michael Allen Gonzalez, Eric Wayne Otterbacher
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Patent number: 6362335Abstract: 2-Amino-5, 8-dimethoxy[1,2,4]triazolo[1,5-c]-pyrimidine is prepared from a 5-chloro or 5-methoxy substituted 3-amino-8-methoxy[1,2,4]triazolo[4,3-c]-pyrimidine by reaction with methoxide in an alcohol solvent. Both rearrangement and, when the 5-substituent is chloro, methoxy substitution can be accomplished directly.Type: GrantFiled: June 15, 2001Date of Patent: March 26, 2002Assignee: Dow AgroSciences LLCInventors: Mark Victor Michael Emonds, Gary A. Roth
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Publication number: 20020013230Abstract: 2-Amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]-pyrimidine is prepared from a 5-chloro or 5-methoxy substituted 3-amino-8-methoxy[1,2,4]triazolo[4,3-c]-pyrimidine by reaction with methoxide in an alcohol solvent. Both rearrangement and, when the 5-substituent is chloro, methoxy substitution can be accomplished directly.Type: ApplicationFiled: June 15, 2001Publication date: January 31, 2002Inventors: Mark Victor Michael Emonds, Gary A. Roth
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Patent number: 6337331Abstract: Substituted or 6,7-ring fused 1,2,3-triazolo[1,5-&agr;]-pyrimidine derivatives are selective ligands for GABAA receptors useful in the treatment of disorders of the central nervous system, including anxiety and convulsions.Type: GrantFiled: November 8, 2000Date of Patent: January 8, 2002Assignee: Merck Sharp & Dohme Ltd.Inventors: Howard Barff Broughton, Jose Luis Castro Pineiro, Ian James Collins, Karl Richard Gibson, Michael Rowley, Leslie Joseph Street
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Publication number: 20010044436Abstract: New bicyclic based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.Type: ApplicationFiled: December 15, 2000Publication date: November 22, 2001Inventors: John M. Nuss, Xiaohui A. Zhou
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Patent number: 6297251Abstract: The novel compounds of formula I: (R1, R2 and Hal are defined in the specification) show selective fungicidal activity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.Type: GrantFiled: December 8, 1999Date of Patent: October 2, 2001Assignee: American Cyanamid Co.Inventors: Klaus-Juergen Pees, Guido Albert
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Patent number: 6297195Abstract: The invention concerns novel substituted triazoloazine sulphonamides of formula (I) in which Q1 stands for nitrogen or a CH group: Q2 stands for nitrogen or a CH group; R1 stands for hydrogen or halogen, or for C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylamino or di(C1-C4 alkyl)amino, in each case optionally substituted by hydroxy, halogen or C1-C4 alkoxy; R2 stands for hydrogen or halogen, or for C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylamino or di(C1-C4 alkyl)amino, in each case optionally substituted by halogen; and Ar stands for 4-cyano-2,5-difluoro-phenyl, 2,6-dimethoxy-phenyl, 2-bromo-3-trifluoro-methyl-phenyl, 2-bromo-5-trifluoromethyl-phenyl, 6-chloro-pyridine-3-yl-methyl or one of the 5- or 6-member (hetero)cyclic groups mentioned in the description. The invention also concerns salts of these substances, a process for preparing the novel compounds, and their use as plant-treatment agents.Type: GrantFiled: May 10, 1999Date of Patent: October 2, 2001Assignee: Bayer AktiengesellschaftInventors: Ernst Rudolf F. Gesing, Mark Wilhelm Drewes, Johannes R. Jansen, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Müller, Ulrich Philipp, Hans-Jochem Riebel, Otto Schallner, Detlef Wollweber, Markus Dollinger, Klaus Stenzel, Christoph Erdelen
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Patent number: 6284762Abstract: The novel compounds of formula I: (R1, R2, R3, L1, L2 and Hal are defined in the specification) show selective fungicidal activity. These compounds may be processed with carriers, and optionally an adjuvant, to produce fungicidal compositions.Type: GrantFiled: March 19, 1999Date of Patent: September 4, 2001Assignee: American Cyanamid CompanyInventor: Waldemar Pfrengle
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Patent number: 6277857Abstract: The novel compounds of formula I: wherein (R1, R2, R3, A, X, L and n through L5 are defined in the specification) show high fungicidal activity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.Type: GrantFiled: September 24, 1999Date of Patent: August 21, 2001Assignee: American Cyanamid CompanyInventors: Waldemar Pfrengle, Klaus-Juergen Pees
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Patent number: 6255309Abstract: The novel compounds of formula I: wherein (R1, R2, Hal and L1 through L5 are defined in the specification) show selective fungicidal activity. The new compounds may be processed with carriers and adjuvants to produce fungicidal compositions.Type: GrantFiled: March 19, 1999Date of Patent: July 3, 2001Assignee: American Cyanomid Co.Inventors: Klaus-Juergen Pees, Guenter Krummel, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Leslie May, Waldemar Pfrengle
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Patent number: 6245769Abstract: Corticotropin releasing factor (CRF) antagonists of Formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.Type: GrantFiled: September 1, 1998Date of Patent: June 12, 2001Assignee: DuPont Pharmaceuticals CompanyInventors: Argyrios G. Arvanitis, Paul J. Gilligan, James P. Beck, Rajagopal Bakthavatchalam
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Patent number: 6242451Abstract: The novel compounds of formula I: (R1 to R5 and X are defined in the specification) show selective fungicidal activity, in particular against rice blast disease. The new compounds are processed with carriers and, optionally, an adjuvant to provide fungicidal compositions.Type: GrantFiled: September 24, 1999Date of Patent: June 5, 2001Inventor: Klaus-Juergen Pees
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Patent number: 6229011Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.Type: GrantFiled: August 21, 1998Date of Patent: May 8, 2001Assignee: Hoffman-La Roche Inc.Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achyutharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
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Patent number: 6222035Abstract: [1,2,4]Triazolo[1,5-c]pyrimidine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof are provided, which have adenosine A2A receptor antagonism and are useful for the treatment or prevention of various diseases induced by hyperactivity of adenosine A2A receptors (for example, Parkinson's disease or senile dementia): wherein R1 represents substituted or unsubstituted aryl, or the like; R2 represents hydrogen, halogen, lower alkyl, substituted or unsubstituted aryl, or the like; R3 represents hydrogen, halogen, XR10 (wherein X represents O or S; and R10 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic ring, substituted or unsubstituted aralkyl, lower alkyl, or hydroxy lower alkyl), or the like; and Q represents hydrogen or 3,4-dimethoxybenzyl.Type: GrantFiled: September 23, 1999Date of Patent: April 24, 2001Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiroshi Tsumuki, Junichi Shimada, Hironori Imma, Akiko Nakamura, Hiromi Nonaka, Shizuo Shiozaki, Shunji Ichikawa, Tomoyuki Kanda, Yoshihisa Kuwana, Michio Ichimura, Fumio Suzuki
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Patent number: 6204269Abstract: The novel optically active compounds of formula I: (R1, Hal and L1 through L5 are defined in the specification) wherein the enantiomeric excess of the (S)-enantiomer is at least 70%., show enhanced selective fungicidal activity. The new compounds are processed with carriers, and optionally with adjuvants, to form fungicidal compositions.Type: GrantFiled: September 24, 1999Date of Patent: March 20, 2001Assignee: American Cyanamid Co.Inventors: Waldemar Pfrengle, Klaus-Juergen Pees, Guido Albert, Paul Carter, Annerose Rehnig, Henry Van Tuyl Cotter
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Patent number: 6194410Abstract: The present invention is concerned with pyrazolopyrimidines and pyrazolotriazines of the general formula and their pharmaceutically acceptable salts. Surprisingly, these compounds evidence selective affinity to 5HT-6 receptors. They are accordingly suitable for use in the treatment and prevention of central nervous disorders such as, for example, psychoses, schizophrenia, manic depressions, depressions, neurological disorders, memory disorders, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease and Huntington's chorea.Type: GrantFiled: February 24, 1999Date of Patent: February 27, 2001Assignee: Hoffman-La Roche Inc.Inventors: Michael Bös, Claus Riemer, Heinz Stadler
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Patent number: 6165942Abstract: A compound represented by the general formula (I) and a salt thereof: ##STR1## wherein: Rf represents a (C.sub.1 -C.sub.4)haloalkyl group; X.about.Y represents N.dbd.N or CH.dbd.N or the like; A represents a nitrogen atom or CH; Z represents an oxygen or sulfur atom; Rg represents a hydrogen or halogen atom and the like; R1, R2, R3, R4 and R5 are each independently represent a hydrogen or halogen atom or a nitro or cyano group or the like.Type: GrantFiled: April 1, 1999Date of Patent: December 26, 2000Assignee: Nissan Chemical Industries, Ltd.Inventors: Jun Satow, Yoshihiro Kudo, Eitatsu Ikeda, Tsutomu Nawamaki, Chiaki Kawaguchi
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Patent number: 6162915Abstract: Chlorosulfonyl substituted aromatic heterocyclic compounds, such as 2-chlorosulfonyl[1,2,4]triazolo[1,5-c]pyrimidine compounds, were prepared in good yield by chloroxidation of di(aromatic heterocyclyl) disulfide compounds in a medium containing water, a water-immiscible organic solvent, and a phase transfer catalyst, such at tetrabutylammonium chloride.Type: GrantFiled: June 25, 1998Date of Patent: December 19, 2000Assignee: Dow AgroSciences LLCInventors: Douglas L. Pearson, Jimmy J. Tai, Timothy J. Adaway
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Patent number: 6124301Abstract: Adjuvants selected from liquid polyalkoxylated aliphatic alcohols, solid sodium hydrocarbyl sulfonates and polyalkoxylated trisiloxanes enhance the efficacy of fungicidal triazolopyrimidines. They can be incorporated into formulations of the fungicidal compounds or be added to spray mixtures (tank mix) as separately formulated additives in order to improve the efficacy, systemicity and spectrum of these fungicides.Type: GrantFiled: March 15, 1999Date of Patent: September 26, 2000Assignee: American Cyanamid CompanyInventors: Michael Aven, Henry Van Tuyl Cotter, Leslie May
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Patent number: 6121270Abstract: Disclosed are enantiomers diastereomers, salts, solvates, hydrates and mixtures thereof, of formula I: ##STR1## The core moiety is non-cyclic or at least one five- to seven-membered ring, n is an integer from about 4 to about 16, R.sub.1 and R.sub.2 are hydrogen, halogen or C.sub.1-12 alkyl or alkenyl, and (CH.sub.2).sub.n may be substituted by a hydroxyl, halogen, oxygen, a (C.sub.1-4) alkyl group or a dimethylamino group. The compounds and pharmaceutical composition thereof are useful in methods for treating an individual having a disease or treatment-induced toxicity, mediated by second messenger activity.Type: GrantFiled: June 17, 1998Date of Patent: September 19, 2000Assignee: Cell Therapeutics, Inc.Inventors: Gail Underiner, J. Peter Klein, John Michnick, Alistair Leigh, Anil Kumar
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Patent number: 6117876Abstract: The novel compounds of formula I: ##STR1## (R.sup.1, R.sup.2 and Hal are defined in the specification) show selective fungicidal activity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.Type: GrantFiled: April 8, 1998Date of Patent: September 12, 2000Assignee: American Cyanamid CompanyInventors: Klaus-Juergen Pees, Guido Albert
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Patent number: 6114338Abstract: The compounds of the formula: ##STR1## wherein Y is bond or alkylene;Z is bond, alkylene or vinylene;E is(i) 4-15 membered, unsaturated, partially saturated or fully saturated, mono or bicyclic hetero ring containing as hetero atoms, one or two nitrogen atoms, one or two oxygen atoms or one sulfur atom,(ii) 4-15 membered, unsaturated or partially saturated, mono or bicyclic carbocyclic ring, or(iii) --OR.sup.4 (in which R.sup.4 is hydrogen atom, alkyl or alkyl substituted by a hydroxy group);Cyc is benzene, pyridine or imidazole;R.sup.1 is hydrogen or alkyl;R.sup.2 is hydrogen, alkyl, alkoxy or halogen atom;R.sup.3 is hydrogen, alkyl, alkoxy or --COOR.sup.5 (in which R.sup.5 is hydrogen or alkyl);with the proviso that(1) a Cyc ring should not bond to Z through a nitrogen atom in the Cyc ring when Z is vinylene and that(2) Y is not a single bond, when E is --OR.sup.Type: GrantFiled: October 13, 1999Date of Patent: September 5, 2000Assignee: ONO Pharmaceutical Co., Ltd.Inventors: Sung Jai Lee, Yoshitaka Konishi, Orest Taras Macina, Kigen Kondo, Dingwei Tim Yu, Manton Rodgers Frierson, Masafumi Sugitani
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Patent number: 6090932Abstract: A method for the preparation of 2'-modified nucleosides is provided. The method comprises a novel intramolecular nucleophilic displacement reaction. Included in the invention are novel 2'-modified pyrimidines and purines prepared according to the method of the invention, novel pyrimidines and purines bearing a 2',3' heterocyclic substituent and oligonucleotides containing said 2'-modified pyrimidines and purines. The 2'-modified nucleosides are useful as anti-viral and anti-neoplastic agents.Type: GrantFiled: October 30, 1996Date of Patent: July 18, 2000Assignee: Proligo LLCInventors: Danny P. McGee, Wolfgang A. Pieken, David P. Sebesta, Yansheng Zhai
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Patent number: 6020338Abstract: The novel compounds of formula I: whereinR.sup.1 represents an optionally substituted alkyl, alkenyl, alkynyl, alkadienyl, or aryl group, or an optionally substituted cycloalkyl or cycloalkenyl group, in which one CH.sub.2 group may also be replaced by O, S or NR.sup.2, in which R.sup.2 represents a hydrogen atom or an alkyl group;X represents a hydrogen or halogen atom, or an alkoxy, aryloxy, aralkyloxy, haloalkoxy, alkylthio, cyano, amino, alkylamino or dialkylamino group;L.sup.1, L.sup.2, L.sup.3, L.sup.4 and L.sup.5 each independently represent an hydrogen or halogen atom or an optionally substituted alkyl or alkoxy group or a nitro or cyano group show selective fungicidal activity. The new compounds are processed with carriers and, optionally, adjuvants, to afford fungicidal compositions, useful in agricultural applications.Type: GrantFiled: February 3, 1999Date of Patent: February 1, 2000Assignee: American Cyanamid CompanyInventors: Waldemar Pfrengle, Klaus-Juergen Pees, Guido Albert
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Patent number: 6005108Abstract: N-(Triazoloazinyl)arylsulfonamide compounds, such as 2,6-dimethoxy-N-(8-chloro-5-methoxy[1,2,4]-triazolo[1,5-c]pyrimidin-2-yl)b enzenesulfonamide, 2-methoxy-4-(trifluoromethyl)-N-(5,8-dimethoxy[1,2,4]-triazolo[1,5-c]pyrim idin-2-yl)pyridine-3-sulfonamide, and 2-methoxy-6-methoxycarbonyl-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-a]pyridin- 2-yl)benzenesulfonamide were prepared from appropriately substituted 2-amino[1,2,4]triazolo-[1,5-c]pyrimidine and 2-amino[1,2,4]triazolo[1,5-a]-pyridine compounds and appropriately substituted benzenesulfonyl chloride and pyridine-3-sulfonyl chloride compounds. The compounds were found to be useful as herbicides.Type: GrantFiled: July 31, 1998Date of Patent: December 21, 1999Inventors: Timothy C. Johnson, Robert J. Ehr, Richard D. Johnston, William A. Kleschick, Mark A. Pobanz, Richard K. Mann, Timothy P. Martin, John C. Van Heertum
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Patent number: 6001830Abstract: The compounds of the formula: ##STR1## wherein ring ##STR2## is a hetero ring containing nitrogen atom, optionally selected from ##STR3## n is 0-2; Y is bond or alkylene;Z is bond, alkylene or vinylene;E is(i) 4-15 membered, unsaturated, partially saturated or fully saturated, mono or bicyclic hetero ring containing as hetero atoms, 1 or 2 N atoms, 1 or 2 O atoms or 1 S atom,(ii) 4-15 membered, unsaturated or partially saturated, mono or bicyclic carbocyclic ring, or(iii) --OR.sup.4 (in which R.sup.4 is hydrogen atom, alkyl or alkyl substituted by a hydroxy group);Cyc is 5-7 membered, unsaturated, partially saturated or fully saturated, monocyclic hetero ring containing as hetero atoms, 1 or 2 N atoms or 5-7 membered, unsaturated or partially saturated, monocyclic carbocyclic ring;R.sup.1 is H or alkyl;R.sup.2 is H, alkyl, alkoxy or halogen atom;R.sup.3 is H, alkyl, alkoxy or --COOR.sup.5 (in which R.sup.Type: GrantFiled: November 12, 1998Date of Patent: December 14, 1999Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Sung Jai Lee, Yoshitaka Konishi, Orest Taras Macina, Kigen Kondo, Dingwei Tim Yu, Manton Rodgers Frierson, Masafumi Sugitani
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Patent number: 5998415Abstract: A class of piperazinones, homopiperazinones and thione analogues thereof, substituted at the 1-position by an optionally substituted alkenyl, alkynyl, aryl-alkyl or heteroaryl-alkyl moiety, and linked at the 4-position via an alkylene spacer to a fused bicyclic heteroaromatic moiety, typically indolyl, are selective agonists of 5-HT.sub.1 -like receptors, being potent agonists of the human 5-HT.sub.1D.alpha. receptor subtype while possessing at least a 10-fold selective affinity for the 5-HT.sub.1D.alpha. receptor subtype relative to the 5-HT.sub.1D.beta. subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT.sub.1D receptors is indicated, while eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT.sub.1D receptor agonists.Type: GrantFiled: April 17, 1998Date of Patent: December 7, 1999Assignee: Merck Sharp & Dohme Ltd.Inventors: Mark Stuart Chambers, Sarah Christine Hobbs, Leslie Joseph Street
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Patent number: 5994360Abstract: The novel compounds of formula I: ##STR1## (A, L, n and R.sup.1 through R.sup.4 are defined in the specification) show selective fungicidal activity. The new compounds can be combined with carriers and adjuvants to form fungicidal compositions.Type: GrantFiled: July 14, 1998Date of Patent: November 30, 1999Assignee: American Cyanamid CompanyInventor: Waldemar Pfrengle
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Patent number: 5985883Abstract: The novel compounds of formula I: ##STR1## (R.sup.1, R.sup.2 and Hal are defined in the specification) show selective fungicidal activity, in particular against rice blast disease. The new compounds are processed with carriers, and optionally an adjuvant, to make fungicidal compositions.Type: GrantFiled: September 25, 1998Date of Patent: November 16, 1999Assignee: American Cyanamid CompanyInventor: Klaus-Juergen Pees
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Patent number: 5986135Abstract: An improved process for the preparation of (S)-1,1,1-trifluoroalkyl-2-amines of formula IIIA, ##STR1## where R.sup.1 is a C.sub.1-6 alkyl group, from the corresponding racemic mixture, which process includes treating 1 part by mole of the racemic mixture with approximately 0.3 to 0.7 part by mole of D-(-)-tartaric acid in the presence of an inert solvent.Type: GrantFiled: September 25, 1998Date of Patent: November 16, 1999Assignee: American Cyanamid CompanyInventors: Waldemar Pfrengle, Klaus-Juergen Pees, Guido Albert, Paul Carter, Annerose Rehnig, Henry Van Tuyl Cotter
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Patent number: 5981534Abstract: The novel compounds of formula I: ##STR1## (R.sup.1, R.sup.2, R.sup.3, L.sup.1, L.sup.2 and Hal are defined in the specification) show selective fungicidal activity. These compounds may be processed with carriers, and optionally an adjuvant, to produce fungicidal compositions.Type: GrantFiled: September 25, 1998Date of Patent: November 9, 1999Assignee: American Cyanamid CompanyInventor: Waldemar Pfrengle
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Patent number: 5973148Abstract: N-arylsulfilimine compounds, such as S,S-dimethyl-N-(2,6-dichlorophenyl)sulfilimine, were prepared and found to catalyze the reaction of aromatic sulfonyl chloride compounds, such as 2-chlorosulfonyl-7-fluoro-5-ethoxy[1,2,4]triazolo[1,5-c]pyrimidine, with aromatic amine compounds, such as 2,6-dichloroaniline, to form N-arylarylsulfonamide compounds, such as N-(2,6-dichlorophenyl)-7-fluoro-5-ethoxy[1,2,4]triazolo[1,5-c]-pyrimidine- 2-sulfonamide. The aryl moiety of the N-arylsulfilimine catalyst and the aryl moiety of the aromatic amine compound were generally chosen to be identical.Type: GrantFiled: December 23, 1998Date of Patent: October 26, 1999Assignee: Dow AgroSciences LLCInventors: James W. Ringer, Carmen A. Scott, Douglas L. Pearson, Anne P. Wallin
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Patent number: 5965561Abstract: The novel compounds of formula I ##STR1## (A and R.sup.1 through R.sup.4 are defined in the specification) show selective fungicidal activity. The new compounds are obtainable by a new synthetic method and processed with carriers and adjuvants to fungicidal compositions.Type: GrantFiled: April 2, 1998Date of Patent: October 12, 1999Assignee: American Cyanamid CompanyInventors: Klaus Jurgen Pees, Peter Liers, Cornelia Karla
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Patent number: 5959106Abstract: N-(substituted aryl)?1,2,4!triazoloazinesulfonamide compounds, such as N-(2,6-difluorophenyl)-8-fluoro-5-methoxy?1,2,4!triazolo?1,5-c!pyrimidine- 2-sulfonamide, were prepared at a good reaction rate and in good yield by the reaction of a chlorosulfonyl?1,2,4!triazoloazine compound, such as 2-chlorosulfonyl-8-fluoro-5-methoxy?1,2,4!triazolo?1,5-c!pyrimidine, and an arylamine compound, such as 2,6-difluoroaniline, in an organic medium containing a relatively acidic alcohol, such as propylene glycol or 2,2,2-trifluoroethanol.Type: GrantFiled: January 25, 1999Date of Patent: September 28, 1999Assignee: Dow AgroSciences LLCInventors: Douglas L. Pearson, Timothy J. Adaway
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Patent number: 5948783Abstract: The novel compounds of formula I: ##STR1## wherein R.sup.1, R.sup.2, Hal and L.sup.1 through L.sup.5, are defined in the specification show selective fungicidal activity.Type: GrantFiled: April 3, 1998Date of Patent: September 7, 1999Assignee: American Cyanamid CompanyInventors: Klaus-Juergen Pees, Guenter Krummel, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Leslie May, Waldemar Pfrengle
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Patent number: 5889006Abstract: Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.21, R.sup.27, R.sup.28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula with acetylcholinesterase inhibitors.Type: GrantFiled: August 8, 1996Date of Patent: March 30, 1999Assignee: Schering CorporationInventors: Derek B. Lowe, Wei K. Chang, Joseph A. Kozlowski, Joel G. Berger, Robert McQuade, Allen Barnett, Margaret Sherlock, Wing Tom, Sundeep Dugar, Lian-Yong Chen, John W. Clader, Samuel Chackalamannil, Yuguang Wang, Stuart W. McCombie, Jayaram R. Tagat, Susan F. Vice, Wayne Vaccaro, Michael J. Green, Margaret E. Browne, Theodros Asberom, Craig D. Boyle
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Patent number: 5858924Abstract: N-(Triazoloazinyl)arylsulfonamide compounds, such as 2,6-dimethoxy-N-(8-chloro-5-methoxy?1,2,4!-triazolo?1,5-c!pyrimidin-2-yl)b enzenesulfonamide, 2-methoxy-4-(trifluoromethyl)-N-(5,8-dimethoxy?1,2,4!-triazolo?1,5-c!pyrim idin-2-yl)pyridine-3-sulfonamide, and 2-methoxy-6-methoxycarbonyl-N-(5,8-dimethoxy?1,2,4!triazolo?1,5-a!pyridin- 2-yl)benzenesulfonamide were prepared from appropriately substituted 2-amino?1,2,4!triazolo-?1,5-c!pyrimidine and 2-amino?1,2,4!triazolo?1,5-a!-pyridine compounds and appropriately substituted benzene-sulfonyl chloride and pyridine-3-sulfonyl chloride compounds. The compounds were found to be useful as herbicides.Type: GrantFiled: September 23, 1997Date of Patent: January 12, 1999Assignee: Dow AgroSciences LLCInventors: Timothy C. Johnson, Robert J. Ehr, Richard D. Johnston, William A. Kleschick, Timothy P. Martin, Mark A. Pobanz, John C. Van Heertum, Richard K. Mann