Abstract: This invention relates to compounds having the formula ##STR1## wherein R represents hydrogen, alkyl containing one to four carbon atoms, or alkoxyalkyl, alkenyl or alkynyl containing two to four carbon atoms, R.sub.1 represents hydrogen or 1-oxoalkyl containing one to two carbon atoms and wherein X and Y are carbon or nitrogen with the proviso that one of X and Y must be nitrogen and the other carbon and which are useful diuretic agents.
Abstract: Disclosed are antibiotic cephalosporins (I) of the formula: ##STR1## Wherein the stylized radical attached to the 7-amino nitrogen of the cephalosporin moiety represents a nitrogen-containing heterocyclic group (mono- or polycyclic); R is, inter alia, hydrogen, alkyl, heterocyclylalkyl, aryl, alkenyl, aralkyl, --NR.sub.2, --OR, COOR, CONR.sub.2 or CN; A is conventionally known in the cephalosporin art; and R.sup.2 is H, or loweralkoxyl; X is O, CH.sub.2, or NR.sup.7 (R.sup.7 is, inter alia, hydrogen, alkyl or aralkyl. Also disclosed are the pharmaceutically acceptable salt and ester derivatives of I; processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
Abstract: 6-(1H-Tetrazol-5-yl)thiozolo[3,2-a]pyrimidin-5-ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo-pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitory action on the immediate hypersensitivity reaction in mammals and relaxant action on the tracheal muscle. Intermediates in the synthesis of these substances from 2-aminoazoles and ethoxy-methylene malononitrile also have smooth muscle relaxant and immediate hypersensitivity reaction inhibitory activity.
Type:
Grant
Filed:
May 5, 1978
Date of Patent:
September 16, 1980
Assignee:
Mead Johnson & Company
Inventors:
Robert R. Covington, Davis L. Temple, Jr., Joseph P. Yevich
Abstract: Triazolone herbicides of the formula: ##STR1## where V is hydrogen, fluorine, chlorine, bromine, methyl or OR where R is alkyl of 1-4 carbon atoms;X is hydrogen, fluorine, chlorine, bromine, cyano, methyl, methoxy, or nitro;Y is hydrogen, fluorine, chlorine, bromine, or methyl;n, m is 0, 1, 2, 3 or 4;Q is oxygen or sulfur;Z is oxygen, S(O).sub.p or NR';p is 0, 1 or 2 andR' is alkyl of 1--3 carbon atomswith the provisos that(1) n+m=2, 3, or 4; and(2) if n+m=2 or 4 then Y, X.noteq.Hand when Z is S(O)p, n is 1, 2, 3 or 4.
Abstract: This disclosure describes substituted 1,2,4-triazolo[1,5-a]pyrimidines and substituted 1,2,4-triazolo[4,3-a]pyrimidines which possess anxiolytic activity.
Type:
Grant
Filed:
April 27, 1979
Date of Patent:
June 24, 1980
Assignee:
American Cyanamid Company
Inventors:
John P. Dusza, Robert A. Hardy, Jr., Jay D. Albright
Abstract: S-Triazolo-(1,5-a)-pyrimidin-2-yl-5,7-dimethyl-phosphoric acid derivatives of the formula ##STR1## wherein X represents oxygen or sulphur,R.sub.1 represents C.sub.1 -C.sub.6 -alkyl, andR.sub.2 represents C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylamino or di-C.sub.1 -C.sub.6 -alkylamino, processes for producing them, and their use in combating pests.
Abstract: New 1,7-dihydro-1-substituted-3H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidi ne-3-thione and 3-one mesoionic didehydro derivatives which have the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, phenyl-lower alkyl, cycloalkyl or hydroxy-lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is lower alkyl, cycloalkyl or hydroxy-lower alkyl; andX is sulfur or oxygen,Are useful as anti-inflammatory agents.