Additional Chalcogen Attached Directly Or Indirectly To The Diazine Ring By Nonionic Bonding Patents (Class 544/318)
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Patent number: 5539115Abstract: Disclosed in this invention are the phenylpyrimidine derivatives represented by the general formula I: ##STR1## the alcohols represented by the formula: ##STR2## usable as starting material for the preparation of the phenylpyrimidine derivatives, and the processes for preparing such derivatives. The phenylpyrimidine derivatives of the formula I according to the present invention have very excellent properties as a liquid crystal compound and can be utilized effectively for the production of liquid crystal elements.Type: GrantFiled: October 8, 1993Date of Patent: July 23, 1996Assignee: Sumitomo Chemical Company, LimitedInventors: Takayuki Higashii, Masayoshi Minai, Isao Kurimoto, Shoji Toda, Takeshi Tani, Chizu Sekine, Koichi Fujisawa
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Patent number: 5534188Abstract: An acetylene derivative represented by general formula (I): ##STR1## wherein R.sup.1 is saturated or unsaturated alkyl group having 3-20 carbon atoms, R.sup.2 is saturated or unsaturated alkyl group having 1-20 carbon atoms which may optionally be substituted by halogen atom or alkoxyalkyl group having 2-20 carbon atoms, A and B represent phenylene group or the like or taken as --A--B-- represent naphthalene group or the like, m and s are each 0 or 1, n is integer of 1-6, and * means asymmetric carbon atom; a process for producing said acetylene derivative, a liquid crystal composition using the same as active ingredient, and a liquid crystal element using said composition.Type: GrantFiled: June 24, 1994Date of Patent: July 9, 1996Assignee: Sumitomo Chemical Company, LimitedInventors: Masayoshi Minai, Takayuki Higashii, Shoji Toda, Naoyuki Takano, Kayoko Ueda, Koichi Fujisawa
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Patent number: 5527763Abstract: A herbicide containing a pyrimidine or triazine derivative of the formula (I): ##STR1## [wherein A is a furan ring, a pyrimidine ring, a 1,2,4-triazine ring or the like which may suitably be substituted, R is a hydroxyl group or a lower alkoxy group, each of R.sup.1 and R.sup.2 which may be the same or different, is a halogen atom, a lower alkyl group or a lower alkoxy group, W is an oxygen atom or a sulfur atom, and Z is nitrogen or a methine group] and its salt, as an active ingredient, is presented. The pyrimidine or triazine derivative of the present invention has excellent herbicidal effects against noxious weeds in paddy fields, upland fields and non-agricultural fields.Type: GrantFiled: December 8, 1993Date of Patent: June 18, 1996Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.Inventors: Masahiro Miyazaki, Masafumi Matsuzawa, Takumi Yoshimura, Kuniaki Shimizu, Shigehiko Tachikawa
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Patent number: 5525724Abstract: A process for the preparation of chloropyrimidines of the formula ##STR1## in which the substituents may be alkyl, cycloalkyl, aryl or radicals containing heteroatoms, but in which at least one of the substituents R.sup.1 to R.sup.4 must be Cl, which involves:reacting a hydroxy-pyrimidine or its tautomeric keto form with phosphoryl chloride in the presence of an amine or amine hydrochloride;recovering phosphoryl chloride after the reaction by adding phosphorus pentachloride and distilling the phosphoryl chloride; andseparating the chloropyrimidine from the amine hydrochloride by addition of a solvent which will dissolve the chloropyrimidine but not the amine hydrochloride and removing the amine hydrochloride.Type: GrantFiled: February 27, 1995Date of Patent: June 11, 1996Assignee: Huels AktiengesellschaftInventor: Artur Hunds
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Patent number: 5519139Abstract: There is disclosed a novel 4-aminopyrimidine derivative containing an optionally esterified carboxyl group at the 5-position which has potent fungicidal activity as well as insecticidal and miticidal activity. The compound is useful as agricultural fungicides, insecticides and miticides.Type: GrantFiled: May 23, 1995Date of Patent: May 21, 1996Assignee: Shionogi & Co., Ltd.Inventors: Toshikazu Ohtsuka, Moriyasu Masui, Takami Takeda, Michio Masuko, Katsuaki Ohba
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Patent number: 5488112Abstract: The invention relates to dimeric 2-(2'-hydroxyphenyl)benzotriazoles of the formula I ##STR1## in which p is 0 or 1; is C.sub.1 -C.sub.12 alkylene;R.sub.1 and R'.sub.1, independently of one another, are hydrogen, halogen, C.sub.1 -C.sub.18 aklyl, C.sub.1 -C.sub.18 alkoxy or --CN;R.sub.2 and R'.sub.2, independently of one another, are hydrogen or C.sub.1 -C.sub.18 alkyl or together are C.sub.2 -C.sub.12 alkylene or C.sub.2 -C.sub.12 hydroxyalkylene; andR.sub.3 and R'.sub.3, independently of one another, are hydrogen, halogen, C.sub.1 -C.sub.18 alkyl or C.sub.1 -C.sub.18 alkoxy.The compounds of formula I are highly suitable for the stabilization of organic material against the harmful effects of heat, oxygen and light, in particular UV radiation.Type: GrantFiled: February 22, 1995Date of Patent: January 30, 1996Assignee: Ciba-Geigy CorporationInventors: Dieter Reinehr, Jean-Pierre Bacher, Andre Schmitter
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Patent number: 5472965Abstract: A novel imidazole derivatives of formula I: ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, or optionally substituted aryl; R.sup.2 is alkyl, optionally substituted aryl optionally substituted aralkyl, or optionally substituted hetero ring group; R.sup.3 is hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, or optionally substituted hydroxyalkyl; R.sup.4 is hydrogen, alkyl, halogen, acyl, optionally substituted hydroxyalkyl, optionally esterified or amidated carboxyl group, hydroxy group, aryl or arylthio; X is S, SO, SO.sub.2, CH.sub.2, or Se; n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof, said derivative having anti-HIV activity and being useful for the treatment of HIV infections.Type: GrantFiled: March 14, 1994Date of Patent: December 5, 1995Assignee: Shionogi & Co., Ltd.Inventors: Hirohiko Sugimoto, Masaru Ogata, Hiroshi Matsumoto, Ken-ichi Sugita, Akihiko Sato, Tamio Fujiwara
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Patent number: 5470819Abstract: This invention relates to derivatives of acrylic acid useful in agriculture (especially as fungicides but also as plant growth regulators, insecticides and nematocides), to processes for preparing them, to agricultural (especially fungicidal) compositions containing them, and to methods of using them to combat fungi, especially fungal infections in plants, to regulate plant growth and to kill or control insect or nematode pests.The invention provides a compound having the formula (I): ##STR1## and stereoisomers thereof, wherein W is a substituted pyridinyl or substituted pyrimidinyl group linked to A by any of its ring carbon atoms; A is either an oxygen atom or S(O).sub.n wherein n is 0, 1 or 2; X, Y and Z, which are the same or different, are hydrogen or halogen atoms, or hydroxy, optionally substituted alkyl (including haloalkyl), optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy.Type: GrantFiled: May 9, 1994Date of Patent: November 28, 1995Assignee: Zeneca LimitedInventors: Vivienne M. Anthony, John M. Clough, Paul deFraine, Christopher R. A. Godfrey, Ian Ferguson, Patrick J. Crowley, Michael G. Hutchings
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Patent number: 5461152Abstract: Compounds of the formulae I and Ia and their racemates ##STR1## in which A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 --, R.sub.1 is hydrogen or a protective group, R.sub.2 is hydrogen or a protective group or a radical forming a phosphorus-containing nucleotide bridge group and B is a purine or pyrimidine radical or an analogue thereof, can be used as antiviral active ingredients or for the preparation of biologically active oligonucleotides.Type: GrantFiled: June 28, 1993Date of Patent: October 24, 1995Assignee: Ciba-Geigy CorporationInventors: Karl-Heinz Altmann, Rene Imwinkelried, Albert Eschenmoser
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Patent number: 5459145Abstract: Antidepressant agents having the formula ##STR1## wherein R.sup.1 is a polycycloalkyl group; R.sup.2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic heterocyclic rings having a total of three nitrogen atoms, one in each ring and one angular nitrogen.Type: GrantFiled: January 19, 1988Date of Patent: October 17, 1995Assignee: Pfizer Inc.Inventors: Nicholas A. Saccomano, Fredric J. Vinick
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Patent number: 5446013Abstract: Pyrimidinyl- or triazinyloxy- (or -thio)-carboxylic acid derivatives, processes for their preparation, and their use as herbicides or plant growth regulatorsCompounds of the formula (I) ##STR1## in which A is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X and Y are as defined in claim 1 are suitable as selective herbicides and plant growth regulators.Type: GrantFiled: December 17, 1993Date of Patent: August 29, 1995Assignee: Hoechst AktiengesellschaftInventors: Frank Zurmuhlen, Klaus Bauer, Hermann Bieringer
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Patent number: 5440042Abstract: Disclosed is a novel near-infrared absorbing dye of formula: ##STR1## wherein X.sup.1, X.sup.2 independently represents --CR.sup.8 R.sup.9 --, --S--, --Se--, --NR.sup.10 --, --CH.dbd.CH-- or --O--;n is an integer of 2 or 3;R.sup.1 and R.sup.2 independently represent alkyl of 1 to 10 carbons or substituted alkyl of 1 to 10 carbons;R.sup.3 represents a ring chosen from the set consisting of aryl, substituted aryl, and heterocyclic containing 5 or 6 carbons in the ring;R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently represent hydrogen, alkyl of 1-10 carbons, substituted alkyl of 1-10 carbons, R.sup.4 and R.sup.5 taken together or R.sup.6 and R.sup.7 taken together may represent the atoms necessary to form a 5 or 6-membered aliphatic ring, an aromatic six-membered ring, an aromatic 10-membered ring, a substituted aromatic six-member ring or a substituted aromatic 10-member ring;R.sup.8, R.sup.Type: GrantFiled: May 26, 1993Date of Patent: August 8, 1995Assignee: E. I. Du Pont de Nemours and CompanyInventors: Dietrich M. Fabricius, Gregory C. Weed
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Patent number: 5439874Abstract: The invention relates to novel substituted bicyclo[3.1.0]hexanes of the formula ##STR1## in which R.sup.1 represents, e. g., hydroxyl or alkoxy,R.sup.2 to R.sup.8 represent, e. g., hydrogen or alkyl,R.sup.9 and R.sup.10 represent, e.g., methyl or methoxy,X represents, e.g., oxygen,Y represents, e.g., oxygen or sulphur andZ represents, e.g., CH or N,as well as salts of the free acid (R.sup.1 =OH) and their further functional derivatives, and furthermore to processes and novel intermediates for their preparation, and to their use as herbicides.In addition, a novel process is described for preparing certain 2-keto-bicyclo[3.1.0]hexanes, which are required as intermediates, starting from correspondingly substituted .alpha.,.beta.-unsaturated carbonyl compounds (of the methacrolein type) and .beta.-keto acid esters (of the acetoacetic acid ester type).Type: GrantFiled: July 21, 1993Date of Patent: August 8, 1995Assignee: Bayer AktiengesellschaftInventors: Mark W. Drewes, Rolf Kirsten, Hans-Joachim Santel, Klaus Lurssen, Robert R. Schmidt
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Patent number: 5440040Abstract: The present invention is directed to compounds of formula (I), ##STR1## wherein R.sup.1 is OH, NH.sub.2 ; R.sup.2 is a heteroaromatic or aromatic substituent; R.sup.3 is H, OH, F, OCH.sub.3 ; R.sup.4 is H, F, OH or an ether or ester residue thereof, OCH.sub.3, CN, C.dbd.CH, N.sub.3 ; R.sup.5 is OH or an ether or ester residue thereof including mono, di- and triphosphate esters (.alpha.), wherein n is 0 or 1 and M is hydrogen or a pharmaceutically acceptable counterion such as sodium, potassium, ammonium or alkylammonium; and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising said compounds can be used for therapeutic treatment of virus infections. The present invention is also directed to compounds of formula (I'), ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, as intermediates.Type: GrantFiled: January 18, 1991Date of Patent: August 8, 1995Assignee: Medivir ABInventor: Salo Gronowitz
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Patent number: 5439908Abstract: Compounds of the formula ##STR1## wherein A is a substituted or unsubstituted, aromatic or non-aromatic, monocyclic or bicyclic, heterocyclic radical that is bonded by way of a carbon atom to X; each of R.sub.1 and R.sub.2, independently of the other, is hydrogen or C.sub.1 -C.sub.6 alkyl; X is NR.sub.3, O or S; and R.sub.3 is hydrogen or C.sub.1 -C.sub.4 alkyl, in free form or in salt form, can be used as agrochemical active ingredients and can be prepared in a manner known per se.Type: GrantFiled: October 30, 1992Date of Patent: August 8, 1995Assignee: Ciba-Geigy CorporationInventors: Peter Maienfisch, Manfred Boger, Thomas Pitterna
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Patent number: 5438059Abstract: Fungicidal compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein R.sup.1 is optionally substituted aryl or optionally substituted heteroaryl; Y is oxygen, sulphur or NR.sup.4 ; R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, are hydrogen, C.sub.1-4 alkyl or C.sub.2-4 alkenyl; X is halogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.1-4 alkoxy, nitro or cyano; and n is 0 or an integer of 1 to 4; provided that when Y is oxygen, n is 0 and R.sup.1 is unsubstituted phenyl at least one of R.sup.2 and R.sup.3 is other than hydrogen or methyl.Type: GrantFiled: July 6, 1993Date of Patent: August 1, 1995Assignee: Zeneca LimitedInventors: John M. Clough, Christopher R. A. Godfrey, Paul J. de Fraine, Michael G. Hutchings, Vivienne M. Anthony
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Patent number: 5434267Abstract: Process for the preparation of compounds of the formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3, X and n have the meaning given in the description, by reacting acetates with carbon monoxide in the presence of a basic auxiliary, followed by alkylation. The products are intermediates for fungicidal acrylates.Type: GrantFiled: March 14, 1994Date of Patent: July 18, 1995Assignee: Bayer AktiengesellschaftInventors: Helmut Kraus, Alexander Klausener, Hans-Joachim Diehr
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Patent number: 5426090Abstract: A method of combating undesired plant growth in wheat, comprising treating said undesired plant growth with an effective amount of a compound of the formula I ##STR1## in which n is an integer from 1 to 6;m is an integer from 0 to 2n+2;X represents an oxygen or sulphur atom or a sulphinyl or sulphonyl group;R.sup.1, R.sup.2 and R.sup.3 each independently represents a hydrogen or halogen atom, a formyl, cyano, carboxy or azido group, or an optionally substituted C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, C.sub.1-12 alkoxy, C.sub.2-12 alkenyloxy, C.sub.2-12 alkynyloxy, C.sub.1-12 alkylthio, C.sub.2-12 alkenylthio, C.sub.2-12 alkynylthio, C.sub.1-12 alkylcarbonyl, C.sub.1-12 alkoxycarbonyl, amino, aminoxy or di-C.sub.1-12 alkyliminoxy group;Z represents a hydrogen or halogen atom, a hydroxy group, an optionally substituted C.sub.1-12 alkoxy, C.sub.2-12 alkenyloxy, C.sub.2-12 alkynyloxy, (C.sub.3-8 cycloalkyl)oxy, phenyloxy, C.sub.1-12 alkylthio, C.sub.2-12 alkenylthio, C.sub.Type: GrantFiled: July 12, 1993Date of Patent: June 20, 1995Assignee: Shell Research LimitedInventors: Alastair McArthur, Trevor W. Newton
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Patent number: 5424275Abstract: Novel biphenyl derivatives represented by the formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X.sup.1, X.sup.2, X.sup.3 and Y are as defined hereinafter.Type: GrantFiled: October 14, 1993Date of Patent: June 13, 1995Assignee: Sumitomo Chemical Company, LimitedInventors: Mitsunori Hiratsuka, Toru Uekawa, Naonori Hirata, Kazuo Saito, Hiroyuki Yogai
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Patent number: 5418233Abstract: Heterobiaryl derivatives of the formulaR.sub.1 NH--X.sub.1 --X.sub.2 --X.sub.3 --Y.sub.1 --Y.sub.2 --Y.sub.3 --Y.sub.4 --E (I)whereinR.sub.1, X.sub.1 to X.sub.3 and Y.sub.1 to Y.sub.4 are as defined herein, the tautomers, stereoisomers and mixtures thereof, and the salts, particularly the physiologically acceptable salts, thereof with organic or inorganic acids or bases. The derivatives have valuable pharmacological properties, such as inhibiting cell-cell aggregation and cell-matrix interactions.Type: GrantFiled: October 14, 1992Date of Patent: May 23, 1995Assignee: Karl Thomae GmbHInventors: Guenter Linz, Helmut Pieper, Frank Himmelsbach, Austel: Volkhard, Thomas Mueller, Johannes Weisenberger, Elke Seewaldt-Becker
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Patent number: 5411973Abstract: Compounds of formula I ##STR1## wherein X, A, B, R.sup.1 and R.sup.2 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable ester thereof, processes for preparing the compounds and pharmaceutical compositions comprising them. The compounds are useful as potassium channel openers and as therapeutic agents in the treatment of urinary incontinence.Type: GrantFiled: May 18, 1993Date of Patent: May 2, 1995Assignee: Zeneca LimitedInventors: Keith Russell, James R. Empfield, Cyrus J. Ohnmacht, Keith H. Gibson
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Patent number: 5401711Abstract: The present invention provides a herbicidal composition containing a novel pyrimidine derivative having the formula (1), ##STR1## wherein R.sup.1 is a trifluoromethanesulfonyioxy group, an ethenyl group which may be substituted, or an ethynyl group which may be substituted; R.sup.2 is a hydrogen atom, an alkyl group, 2-trimethylsilyl ethyl group; R.sup.3 and R.sup.4 are the same or different, and are a methoxy group or a halogen atom; X is an oxygen atom or a sulfur atom; and Z is a methine group; or its salt, as an active ingredient.The pyrimidine derivative of the present invention exhibits an excellent herbicidal effect against noxious weeds which grow in paddy fields, upland fields and non-agricultural fields.Type: GrantFiled: February 1, 1993Date of Patent: March 28, 1995Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.Inventors: Masahiro Sato, Koichiro Kaku, Shigehiko Tachikawa
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Patent number: 5395935Abstract: An optically active compound selected from the group consisting of a compound having the absolute stereochemical formula ##STR1## and a compound having the absolute stereochemical formula ##STR2## and intermediates thereof.Type: GrantFiled: October 12, 1993Date of Patent: March 7, 1995Assignee: Pfizer Inc.Inventor: Nicholas A. Saccomano
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Patent number: 5389651Abstract: Compounds of the formula ##STR1## wherein R is hydrogen; C.sub.1-8 alkyl; C.sub.2-8 alkenyl; C.sub.3-8 alkadienyl; C.sub.2-8 alkynyl; C.sub.4-8 alkadiynyl; C.sub.2-10 (alkoxyalkyl); C.sub.2.sub.2-10 (alkylthioalkyl); C.sub.3-8 cycloalkyl and C.sub.4-12 (cycloalkylalkyl); optionally substituted by 1 to 6 halos,R.sup.1 is hydrogen or C.sub.1-8 alkyl,R.sup.2 is hydrogen, C.sub.1-8 alkyl or halo,R.sup.3 is ##STR2## wherein each R.sup.5 and R.sup.6, are independently hydrogen, halo, C.sub.1-8 alkyl, optionally substituted by 1 to 6 halos, C.sub.1-8 alkoxy, C.sub.1-8 alkylthio or nitro,W is --O--, --S--, --NR.sup.4 -- or --CO--,W.sup.1 is --O--, --S--, --SO--, --SO.sub.2 --, --NR.sup.4 -- or --CO--,X is --O--, --S--, --NR.sup.4 -- or ##STR3## wherein R.sup.1 is hydrogen or C.sub.1-8 alkyl,Z is hydrogen, C.sub.1-8 alkyl optionally substituted by 1 to 6 halos,m is 0 or 1,m' is 0 or 1, andn is 0, 1 or 2,wherein each R.sup.4 is independently hydrogen or C.sub.1-8 alkyl, said compounds are useful as pesticides, i.e.Type: GrantFiled: July 27, 1987Date of Patent: February 14, 1995Assignee: Sandoz Ltd.Inventor: Clive A. Henrick
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Patent number: 5387575Abstract: Disclosed are a pyrimidine or triazine compound represented by the following formula (I): ##STR1## wherein R.sup.1 represents cyano group, a halogen atom, hydroxy group or --O--R.sup.7 where R.sup.7 represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a halo-lower alkyl group or a cyano-lower alkyl group; R.sup.2 represents hydrogen atom or a lower alkyl group; R.sup.3 represents hydrogen atom or a lower alkyl group; R.sup.4 represents a 1-imidazolyl group, --NHSO.sub.2 --R.sup.8 where R.sup.8 represents a lower alkyl group or a phenyl group which may have a substituent, hydroxy group, a lower alkoxy group or a benzyloxy group when Z is nitrogen atom; or a 1-imidazolyl group, --NHSO.sub.2 --R.sup.8 where R.sup.Type: GrantFiled: June 5, 1992Date of Patent: February 7, 1995Assignee: Ube Industries, Ltd.Inventors: Katsumasa Harada, Takaaki Abe, Yuji Akiyoshi, Akio Matsushita, Mikio Kojima, Ikuo Shiraishi, Kaoru Yamamoto, Takashi Hayama, Shohei Fukuda
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Patent number: 5385880Abstract: Herbicidal composition containing a compound having the following formula or its salt: ##STR1## wherein W is an oxygen atom, a sulfur atom, a NH group or a group of the formula, >NC(O)B;Z is a methine group or a nitrogen group;X is a phenyl group which may be substituted or a group having the formula: ##STR2## and n is an integer of from 1 to 3.Type: GrantFiled: September 17, 1992Date of Patent: January 31, 1995Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.Inventors: Masahiro Miyazaki, Masafumi Matsuzawa, Keiji Toriyabe, Michiya Hirata
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Patent number: 5385985Abstract: Disclosed is cyclic urea derivatives represented by the following formula (A): ##STR1## wherein n is an integer of 0 or 1; m is an integer of 1 to 15; X is oxygen, sulfur or --NR.sub.1 -- (R.sub.1 is hydrogen or an alkyl group having 1 to 5 carbon atoms); R is an alkyl-, cycloalkyl -, aryl-, aralkyl-, alkaryl- and glycidyl group having 1 to 27 carbon atoms, or an alkyl-, cycloalkyl-, aryl-, aralkyl- and alkaryl group containing at least one ##STR2## O, S and N and having 1 to 27 carbon atoms with a molecular weight of 15 to 500, said groups substituted by glycidyl-, hydroxylic-, nitro groups, halogens, cyano-, formyl- or amino groups, or polyester-, polyether-, polyurethane and polyamide groups having a molecular weight of 500 to 100,000.Type: GrantFiled: September 17, 1992Date of Patent: January 31, 1995Assignee: Nippon Paint Co., Ltd.Inventors: Tsuboniwa Noriyuki, Urano Satoshi, Umemoto Hirotoshi, Sakamoto Hiroyuki, Tobinaga Kenshiro, Tsuchiya Yasuyuki
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Patent number: 5384070Abstract: The use of optically active tetrahydrofuran-2-carboxylic acid esters as dopants in liquid-crystal mixtures, liquid-crystal mixtures containing same and novel optically active tetrahydrofuran-2-carboxylic acid esters.Optically active tetrahydrofuran-2-carboxylic acid esters containing a mesogenic molecular building unit are suitable as dopants in liquid-crystal mixtures. They result in liquid-crystalline ferroelectric phases having short switching times and in electroclinic phases having large electroclinic coefficients. A further advantage is that they induce a helix having a very small pitch so that they are also suitable for helix compensation in LC mixtures.The compounds are symbolized by the general formula: ##STR1## in which the symbols and indices essentially denote: R.sup.1 =alkyl/alkenyl or tetrahydrofurancarbonyloxy or -thio; j, l, n=zero, 1 or 2; k, m=zero or 1; --A.sup.1, --A.sup.2, --A.sup.3 =phenylene, cycloalkylene or corresponding heterocyclates containing nitrogen, oxygen or sulfur; --M.sup.Type: GrantFiled: May 20, 1993Date of Patent: January 24, 1995Assignee: Hoechst AktiengesellschaftInventors: Wolfgang Hemmerling, Hans-Rolf Dubal, Claus Escher, Gerhard Illian, Yoshio Inoguchi, Ingrid Muller, Mikio Murakami, Dieter Ohlendorf, Rainer Wingen
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Patent number: 5380700Abstract: The present invention provides a novel pyridine derivative having the following general formula and its salt: ##STR1## wherein R is a hydrogen atom, a hydroxyl group, an alkoxy group, an alkoxyalkoxy group, and derivatives;R.sup.1 and R.sup.2 may be the same or different, and are a hydrogen atom, an alkoxy group, a halogen atom, an alkylamino group, a dialkylamino group;Z is a methine group or a nitrogen atom;X.sup.1 is an acylamino group, a cycloalkyl group, a halogen-substituted alkoxy group, an alkenyloxy group, an alkynyloxy group, an alkoxycarbonyl group, an alkylamino group, a dialkylamino group, a phenyl group.The pyridine derivative and its salt of the present invention achieve an excellent herbicidal effect on annual and perennial weeds growing in paddy fields and upland fields at a very small dosage.The pyridine derivative and its salt of the present invention have safety to rice, wheat, cotton and corn, and can be suitably applied as a herbicide to a field where these plants are cultivated.Type: GrantFiled: December 23, 1992Date of Patent: January 10, 1995Assignees: Kumiai Chemical Industries Co., Ltd., Ihara Chemical Industries Co., Ltd.Inventors: Masahiro Miyazaki, Masafumi Matsuzawa, Keiji Toriyabe, Michiya Hirata
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Patent number: 5378839Abstract: There are provided 1-(substituted)thioalkylpyrrole compounds of formula I ##STR1## the use thereof for the control of insect, acarid and mollusk pests and methods and compositions for the protection of crops from the ravages of said pests.Type: GrantFiled: January 26, 1994Date of Patent: January 3, 1995Assignee: American Cyanamid CompanyInventors: David G. Kuhn, Venkataraman Kameswaran
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Patent number: 5378711Abstract: .alpha.-Arylacrylates substituted by a heterocyclic radical and of the general formula I ##STR1## where R.sup.1 is alkoxy or alkylthio, R.sup.2 is alkyl, Het is quinolyl, which is unsubstituted or substituted, A is oxygen and n is 1, and their plant-tolerated acid addition salts and metal complexes, and the N-oxides of the heterocyclic compounds, and fungicides containing these compounds.Type: GrantFiled: December 28, 1992Date of Patent: January 3, 1995Assignee: BASF AktiengesellschaftInventors: Franz Schuetz, Thomas Kuekenhoehner, Jochen Wild, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz
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Patent number: 5371062Abstract: The present invention relates to new substituted azines, of the general formula (I) ##STR1## in which n, Q.sup.1, Q.sup.2, Q.sup.3, R.sup.1, R.sup.2, R.sup.3, X, Y and Z have the meanings given in the description, to a plurality of processes for their preparation, and to their use as herbicides.Type: GrantFiled: April 1, 1993Date of Patent: December 6, 1994Assignee: Bayer AktiengesellschaftInventors: Roland Andreee, Mark W. Drewes, Hans-Joachim Santel, Klaus Lurssen, Robert R. Schmidt
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Patent number: 5354500Abstract: Use of optically active carboxylic esters of oxygen-containing heterocycles as doping substances in liquid crystal mixtures and liquid crystal mixtures containing them.Optically active 1,3-dioxolane-4-carboxylic esters and oxirane-2-carboxylic esters of the general formula (I)R(--A.sup.1).sub.j (--M.sup.1).sub.k (--A.sup.2).sub.l (--M.sup.2).sub.m (--A.sup.3).sub.n --X--Acin whichR.sup.1 is, for example, (C.sub.1 -C.sub.16)-alkyl or (C.sub.1 -C.sub.16)-alkoxy,A.sup.1, A.sup.2, A.sup.3 are, for example, phenyl or pyrimidine-2, 5-diyl,M.sup.1, M.sup.2 are, for example, CO--O, CH.sub.2 --CH.sub.2,j, l are 0, 1, 2,k, m are 0, 1,n is 0, 1, 2,X is O, S andAc is ##STR1## in which R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 for example, H or methyl, are particularly suitable doping substances for liquid crystalline mixtures, since they induce a high spontaneous polarization and effect a substantial decrease in the melting point.Type: GrantFiled: April 17, 1992Date of Patent: October 11, 1994Assignee: Hoechst AktiengesellschaftInventors: Wolfgang Hemmerling, Ingrid Muller, Hans-Rolf Dubal, Claus Escher, Gerhard Illian, Mikio Murakami, Dieter Ohlendorf, Rainer Wingen
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Patent number: 5354944Abstract: 4-Carboxy-2-aryloxyphenoxyalkyl substituted heterocycle compounds which are effective for the selective control of grass weed species in the presence of crops are described. Also described are a method for the selective herbicidal use of the compounds and methods for their preparation.Type: GrantFiled: January 25, 1993Date of Patent: October 11, 1994Assignee: American Cyanamid CompanyInventors: Robert L. Arotin, Michael Anthony
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Patent number: 5350750Abstract: .beta.-carboline-3-hydroxyalkylcarboxylic acid ester derivatives of formula I ##STR1## in which R.sup.A, n, R.sup.4 and R.sup.3, have the meaning indicated in the claims, as well as their production and their use in pharmaceutical agents are described.Type: GrantFiled: March 1, 1993Date of Patent: September 27, 1994Assignee: Schering AktiengesellschaftInventors: Andreas Huth, Martin Kruger, Dieter Seidelmann, Ralph Schmiechen, Werner Krause, Herbert Schneider, Lechoslaw Turski
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Patent number: 5346880Abstract: This invention relates to novel pyrimidinylthioalkane derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are defined in the specification and A represents hydroxy, and B represents hydrogen or A and B together form a carbonyl group, a process for their production and a method of using said derivatives to combat unwanted plant growth.Type: GrantFiled: April 6, 1993Date of Patent: September 13, 1994Assignee: Nihon Bayer Agrochem K.K.Inventors: Toshio Goto, Yoshinori Kitagawa, Hidenori Hayakawa, Katsuhiko Shibuya, Ryo Watanabe
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Patent number: 5346914Abstract: Compounds of the structure ##STR1## wherein W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.6 and R.sup.7 are hydrogen or alkyl, or R.sup.6 and R.sup.7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## R.sup.8 is selected from hydrogen, alkyl, haloalkyl, optionally substituted phenyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, (alkoxycarbonyl)alkyl, and (alkylaminocarbonyl)alkyl; Z is --CH.sub.2 --, oxygen, sulfur, or --NR.sup.9 where R.sup.9 is hydrogen or alkyl, L.sup.1 and L.sup.2 are selected from a valence bond, alkylene, propenylene, and propynylene, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from alkyl, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is selected from oxygen, --NR.sup.10, where R.sup.10 is hydrogen or alkyl, and ##STR4## where n=0, 1, or 2, and R.sup.5 is alkyl, inhibit the biosynthesis of leukotrienes.Type: GrantFiled: May 14, 1993Date of Patent: September 13, 1994Assignee: Abbott LaboratoriesInventors: Joseph F. Dellaria, Anwer Basha, Lawrence A. Black, Linda J. Dorn, Wendy Lee
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Patent number: 5338844Abstract: A 2-substituted-2-cyclopentenone compound represented by the following formula (I) and an anticancer agent and a bone formation accelerator comprising the same as an effective active ingredient: ##STR1##Type: GrantFiled: July 16, 1993Date of Patent: August 16, 1994Assignee: Teijin LimitedInventors: Satoshi Sugiura, Toru Minoshima, Atsuo Hazato, Yoshinori Kato
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Patent number: 5332717Abstract: The invention relates to compounds of formula ##STR1## wherein W, X, Y.sup.1, Y.sup.2, Z, R.sup.1, R.sup.2 and R.sup.14 are as defined in the description, and to the preparation thereof, to weed control compositions and plant-growth-regulating compositions comprising such compounds as active ingredients, and to the use of the active ingredients or compositions for controlling weeds and for regulating plant growth.Type: GrantFiled: April 15, 1993Date of Patent: July 26, 1994Assignee: Ciba-Geigy CorporationInventors: Christoph Luthy, Jean-Pierre Obrecht
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Patent number: 5330989Abstract: Biphenyl derivatives of cyclobutene-1,2-dione of formula 1 are angiotensin II antagonists and are useful for the treatment of hypertension and congestive heart failure ##STR1## wherein: Y is O, NR.sup.7, NCOR.sup.7 ; or R.sup.5 and Y taken together represent a linking chain of N.dbd.CR.sup.8 N; or R.sup.5 and Y taken together represent a linking chain of (CR.sup.9 R.sup.10).sub.n CON where n=1,2,3,4, or 5;X is N, CR.sup.7 ;Z is N, CR.sup.7 ;R.sup.1 is H, alkyl, benzyl, alkoxyalkyl, phenyl;R.sup.2 is H, alkyl, benzyl, alkoxyalkyl, phenyl, alkoxy, alkyl-OH, perfluoroalkyl, F, Cl, Br, I, NR.sup.7 R.sup.8 ;R.sup.3 is H, alkyl, benzyl, alkoxyalkyl, phenyl, alkoxy, alkyl-OH, perfluoroalkyl, F, Cl, Br, I, NR.sup.7 R.sup.8 ;R.sup.4 is H, NR.sup.7 R.sup.8, OR.sup.1, CN, F, Cl, I, Br, perfluoroalkyl, alkyl, phenyl, alkoxy, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.1, --(CH.sub.2).sub.n CONR.sup.7 R.sup.8 where n=1, 2, 3, 4, or 5;R.sup.5, R.sup.Type: GrantFiled: September 11, 1992Date of Patent: July 19, 1994Assignee: American Home Products CorporationInventors: Richard M. Soll, William A. Kinney
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Patent number: 5328639Abstract: A liquid crystal composition, comprising: at least one optically active mesomorphic compound having an asymmetric carbon atom to which a fluorine atom is directly bonded.Type: GrantFiled: December 31, 1992Date of Patent: July 12, 1994Assignee: Canon Kabushiki KaishaInventors: Hiroyuki Nohira, Masanao Kamei, Shinichi Nakamura, Kazuharu Katagiri, Masahiro Terada, Masataka Yamashita, Yoko Yamada, Kenji Shinjo, Takashi Iwaki, Chieko Hioki, Akio Yoshida, Toshiharu Uchimi
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Patent number: 5326767Abstract: .alpha.-Arylacrylates substituted by a heterocyclic radical and of the general formula I ##STR1## where R.sup.1 is alkoxy or alkylthio, R.sup.2 is alkyl, Het is pyridyl, pyridone, quinolyl, pyrimidinyl, pyrimidinone, the heterocyclic ring system being unsubstituted or substituted, A is carbonyloxy, oxygen or sulfur, and n is 0 or 1, and their plant-tolerated acid addition salts and metal complexes, and the N-oxides of the heterocyclic compounds, and fungicides containing these compounds.Type: GrantFiled: June 11, 1992Date of Patent: July 5, 1994Assignee: BASF AktiengesellschaftInventors: Franz Schuetz, Thomas Kuekenhoehner, Jochen Wild, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz
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Patent number: 5324837Abstract: 3,4-Diaryl-4,5-dihydro-1H-pyrazole compounds having a selected 5- or 6-membered aromatic heterocyclic moiety in the 4-position and an optionally substituted phenyl moiety in the 3-position, such as 4,5-dihydro-3-(4-fluorophenyl)-4-(5-trifluoromethyl-2-pyridinyl)-1H-pyrazo le were prepared as intermediates in the preparation of insecticidal 3,4,N-triaryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds. The 3,4-diaryl-4,5-dihydro-1H-pyrazole compounds can be prepared from appropriate 1,2-diarylethanone compounds by successive treatments with N,N,N',N'-tetramethyldiaminomethane in dichloromethane in the presence of acetic anhydride (to form a Mannich adduct) and hydrazine in the presence of a catalytic amount of trifluoroacetic acid.Type: GrantFiled: August 17, 1992Date of Patent: June 28, 1994Assignee: DowElancoInventors: James M. Renga, Kevin L. McLaren, James T. Pechacek, Michael J. Ricks, Yulan C. Tong
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Patent number: 5318946Abstract: 2-(Heteroaryloxyphenoxy)alkylsulfonate compounds which are effective for the selective control of grass weed species in the presence of crops are described. Also described are a method for the selective herbicidal use of the compounds and a method for their preparation.Type: GrantFiled: November 27, 1991Date of Patent: June 7, 1994Assignee: American Cyanamid CompanyInventors: Michael E. Condon, Michael A. Guaciaro
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Patent number: 5318945Abstract: Thiocarboxylic acid derivatives useful as herbicides or plant growth regulators are of the general formula I ##STR1## where R.sup.1 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl or cycloalkenyl, unsubstituted or substituted alkenyl or alkynyl or unsubstituted or substituted phenyl;R.sup.2 is halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio;X is nitrogen or CR.sup.6, where R.sup.6 is hydrogen or, together with R.sup.3, forms a C.sub.3 - or C.sub.4 -alkylene chain or C.sub.3 - or C.sub.4 -alkenylene chain in which a methylene group is replaced with oxygen;R.sup.3 is halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio or R.sup.3 is bonded to R.sup.6 as stated above to give a 5-membered or 6-membered ring;R.sup.Type: GrantFiled: December 21, 1992Date of Patent: June 7, 1994Assignee: BASF AktiengesellschaftInventors: Ernst Baumann, Thomas Saupe, Joachim Rheinheimer, Uwe J. Vogelbacher, Matthias Bratz, Norbert Meyer, Matthias Gerber, Karl-Otto Westphalen, Uwe Kardorff, Andreas Landis, Helmut Walter
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Patent number: 5312919Abstract: This invention relates to novel photooxidation products, and derivatives thereof, of Merocyanine 540, their preparation and their uses as anticancer and antiviral agents.Type: GrantFiled: June 12, 1992Date of Patent: May 17, 1994Assignee: Baylor Research InstituteInventors: Kirpal S. Gulliya, Burchard Franck, J. Lester Matthews, Udo Schneider
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Patent number: 5290773Abstract: A sulfonyl compound of the formula ##STR1## The above illuminated formula (I) undergo bimolecular condensation by the condensing agents and easily form simple metal salts especially metal complexes which act as combatting viruses and inhibiting tissue growth.Type: GrantFiled: March 21, 1990Date of Patent: March 1, 1994Inventor: Takeo Takayanagi
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Patent number: 5290477Abstract: An optically active compound represented by formula (I): ##STR1## wherein R.sup.1 represents an alkyl group having from 3 to 9 carbon atoms; R.sup.2 represents an alkyl group having from 3 to 7 carbon atoms; m and n each represent 1 or 2 provided that they do not simultaneously represent 1; and C.sup.*1 and C.sup.*2, both represent an optically active carbon atom, and a liquid crystal composition containing the same are disclosed. The compound exhibits chiral nematic and smectic phases and are excellent as a chiral dopant for ferroelectric liquid crystal compositions or nematic liquid crystal compositions.Type: GrantFiled: July 29, 1993Date of Patent: March 1, 1994Assignee: Takasago International CorporationInventors: Hitoshi Kondo, Mika Tadokoro, Hiroshi Sugiyama, Toshimitsu Hagiwara, Takashi Imai, Mamoru Yamada, Keisuke Itakura
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Patent number: 5290755Abstract: Salicylic acid derivatives and sulfur analogs thereof of the formula I, ##STR1## wherein the substituents are herein below defined.Type: GrantFiled: August 4, 1992Date of Patent: March 1, 1994Assignee: BASF AktiengesellschaftInventors: Uwe J. Vogelbacher, Joachim Rheinheimer, Thomas Saupe, Norbert Meyer, Matthias Gerber, Karl-Otto Westphalen, Helmut Walter
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Patent number: 5286750Abstract: Unsaturated phenylacetic acid derivatives of the general formula ##STR1## where U is .dbd.O, .dbd.CH--OCH.sub.3, .dbd.N--OCH.sub.3, .dbd.N--NH--CH.sub.3, .dbd.CH.sub.2, .dbd.CH--CH.sub.3, .dbd.CH--CH.sub.2 --CH.sub.3 or .dbd.CH--S--CH.sub.3 andZ.sup.1 and Z.sup.2 are hydrogen, halogen, trifluoromethyl, cyanide, NO.sub.2 or unsubstituted or substituted alkyl, alkenyl, aryl, alkynyl, alkoxy, aryloxy, arylalkoxy, acyloxy, hetaryl, --CO.sub.2 R.sup.1, --CONR.sup.2 R.sup.3, COR.sup.4 or NR.sup.5 R.sup.6, and Z.sup.1 and Z.sup.2 may also form a ring,A is meta or para and is (CH.sub.2).sub.n, CH.dbd.CH, O--(CH.sub.2).sub.n, O--(CH.sub.2).sub.n --CO, CH.sub.2 --O--CO--(CH.sub.2).sub.n, CO--O--(CH.sub.2).sub.n, O--CO--(CH.sub.2).sub.n, O--(CH.sub.2).sub.n --CO--O, O--(CH.sub.2).sub.n+2 --O, CH.sub.2 O--(CH.sub.2).sub.n, CH.sub.2 --S--(CH.sub.2).sub.n CH.sub.2 --NR.sup.7 --(CH.sub.2).sub.n, CH(CN)--O--CO--(CH.sub.2).sub.n, CH.dbd.N--(CH.sub.2).sub.n or CH.dbd.N--O--(CH.sub.2).sub.n.Type: GrantFiled: March 15, 1993Date of Patent: February 15, 1994Assignee: BASF AktiengesellschaftInventors: Bernd Mueller, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz, Franz Roehl