Abstract: A dye for heat sensitive transfer recording represented by formula (I): ##STR1## wherein Q.sup.1 represents an atomic group, which includes at least one nitrogen atom, which is required, together with the carbon atoms to which said atomic group is bonded, to form an at least five membered nitrogen containing heterocyclic ring; R.sub.1 represents an acyl group or a sulfonyl group; R.sub.2 represents a hydrogen atom or an aliphatic group which has from 1 to 6 carbon atoms; R.sub.3 represents a hydrogen atom, a halogen atom, an alkoxy group, or an aliphatic group which has from 1 to 6 carbon atoms; R.sub.4 represents a halogen atom, an alkoxy group, or an aliphatic group which has from 1 to 6 carbon atoms; n represents an integer of from 0 to 4; R.sub.3 may be joined to R.sup.1, R.sup.2, or R.sup.4 to form a ring; R.sup.5 and R.sup.6, which may be the same or different, each represents a hydrogen atom, an aliphatic group which has from 1 to 6 carbon atoms, or an aromatic group; R.sup.5 and R.sup.

Abstract: A compound having the formula ##STR1## in which X is O, S, or Se; each R.sub.1, R.sub.2, and R.sub.3, independently, is H, a lower alkyl, or aralkyl; A is a saturated or unsaturated ring; and each Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4, Z.sub.5, Z.sub.6, Z.sub.7, or Z.sub.8, independently, is H or a halogen,provided that when X is O, at least one group Z is a halogen; when either Z.sub.2 or Z.sub.3 is a halogen, at least one of R.sub.2 or R.sub.3 is H; and when both Z.sub.2 and Z.sub.3 are halogens, both R.sub.2 and R.sub.3 are H;or a pharmaceutically acceptable salt thereof.The compounds are useful for photo-inactivation of cancer cells.

Abstract: Hydrolyzable substrates comprise blocked moieties which, when cleaved from the substrate during hydrolysis, provide electron transfer agents. The released electron transfer agents can be recycled between a reductant and a reducible compound that upon reduction provides a detectable species. Alternatively, they can be recycled between an oxidant and an oxidizable compound that upon oxidation provides a detectable species. These substrates are useful in analytical compositions, elements and methods for the determination of hydrolytic analytes, such as hydrolytic enzymes or biological cells containing such enzymes.

Abstract: Novel adducts of oxazine urea chromophors or thiazine urea chromophors with organic substrates are provided which are useful in analytical techniques for the detection and measurement of biological and clinical compounds of interest.

Abstract: A compound of the formula ##STR1## wherein X has the formula ##STR2## wherein ring A is phenyl, naphthyl or heterocyclic; wherein R.sup.1 is hydrogen, alkyl, alkanoyl or aroyl; wherein R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each is an electron withdrawing substituent selected from halogeno, nitro, cyano, trifluoromethyl, alkylthio, alkylsulphinyl and alkylsulphonyl or each is hydrogen, alkyl, alkoxy or dialkylamino provided that when ring A is phenyl or naphthyl at least one of R.sup.2, R.sup.3 and R.sup.4 is an electron-withdrawing substituent; wherein R.sup.5 and R.sup.6, which may be the same or different, each is hydrogen, halogeno or alkyl; wherein R.sup.7 is alkyl or halogenoalkyl; and wherein R.sup.8 is carbamoyl, alkyl, cycloalkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalkenyl, halogenoalkynyl, alkanoyl, alkylcarbamoyl, dialkylcarbamoyl or aroyl; or wherein R.sup.

Abstract: A new leuco dye is capable of developing into a colored dye which has an absorption band in the near infrared region. The new leuco dye has the following formula (I): ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 independently is hydrogen, an alkyl group, an aralkyl group, a cycloalkyl group or an aryl group; each of X.sup.1 and X.sup.2 independently is oxygen, sulfur or --NR.sup.4 -- (R.sup.4 has the same meaning as for R.sup.1, R.sup.2 and R.sup.3); each of the rings A to E independently is benzene ring or naphthalene ring and may have one or more substituent groups; and each of R.sup.1 to R.sup.4 may have one or more substituent groups. A recording material containing the leuco dye is also disclosed.

Abstract: Novel chromophor derivatives of cyclic anhydrides are provided which have the ability to react with a variety of organic substrates forming adducts which are useful in analytical techniques for the detection and measurement of biological compounds.

Abstract: This invention describes phenothiazine derivatives which are N-substituted and which contain an additional sulfur molecule in the N substituent.

Abstract: Novel urea derivatives of oxazine and thiazine chromophors have the structural formula I or II. ##STR1## wherein M is oxygen or sulfur, R.sub.1 and R.sub.2 are aliphatic alkyl groups or hydrogen; R.sub.3 is hydrogen or alkyl group; R.sub.4 is hydrogen, alkyl or amine group; R.sub.5 is hydrogen, amine or alkyl group; X.sup..crclbar. is an anion consisting of an organic (e.g. CH.sub.3 COO.sup..crclbar., CH.sub.3 CH.sub.2 COO.sup..crclbar. and the like) or inorganic specie (e.g. Cl.sup..crclbar., Br.sup..crclbar., I.sup..crclbar., ClO.sub.4.sup..crclbar., SO.sub.4 ", and the like); n is 0 to 20; Z is N.dbd.C.dbd.O, N.dbd.C.dbd.S, carboxylic, primary or secondary amine, and when n=0, Z may be ##STR2## wherein Q is hydroxyl, amino, carboxylic, sulfydryl, isocyanato, or isothiocyanato.The functional oxazine-urea and thiazine-urea derivatives react with compounds of interest to form adducts resulting in the fluorescent labeling of the compound.

Abstract: Azine redox dyes and their corresponding dyes of the formula: ##STR1## in which: X is O, S, NR.sup.2,Z completes a fused aromatic of heterocyclic ring system,n is 0 or 1 to allow one R.sup.1 ring substituent,Q represents CR.sup.4 R.sup.5 in which at least one of R.sup.4 and R.sup.5 is an electronegative group or R.sup.4 and R.sup.5 may complete a ring, orwhen X is S Q may represent NR.sup.3 in which R.sup.3 is an aromatic or heterocyclic group.The leuco dyes are useful as dye generators in pressure sensitive, thermographic or photothermographic imaging systems.

Abstract: Dyestuffs of the formula ##STR1## wherein F stands for an organic chromophore andZ stands for radicals of the formulae ##STR2## wherein R.sub.1 -R.sub.2 denote hydrogen, alkyl, cycloalkyl, alkenyl, aryl, aralkyl or a heterocyclic structure orR.sub.2 and R.sub.3 represent an optionally substituted amino group or together form a ring orR.sub.1 with R.sub.2 and/or R.sub.3 with R.sub.4 form a ring,A.sup.(-) denotes an anion,Y denotes an anionic group,m denotes 0-2 andn denotes 1-6,and wherein the chromophore and said radicals can carry further substituents, provided that the total number of anionic substituents is smaller than the total number of quaternary and quaternizable amino groups, are used for dyeing cellulose fibres, in particular paper.

Abstract: A process for the preparation of dioxazine compounds of the formula ##STR1## in which B.sub.1 and B.sub.2 designate a ring system with 1, 2, 3 or 4 carbocyclic and/or heterocyclic rings which can be substituted, andX.sub.1 and X.sub.2 designate hydrogen, halogen, --R', --OR', --NHR', --NR'R", ##STR2## R' and R" representing alkyl, cycloalkyl, aryl and aralkyl and n denoting 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11, it being possible for the n bromine atoms, independently of one another, to replace both H atoms of the ring systems B.sub.1 and B.sub.2 or their substituents and H atoms of X.sub.1 and X.sub.2 as well as X.sub.1 and X.sub.2 themselves,is characterized in that compounds of the formula II ##STR3## are reacted with bromine, preferably in the presence of diluents.

Abstract: Pharmaceutical compositions containing a compound of Formula I: ##STR1## wherein X is O, S, SO or SO.sub.2 and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be positioned anywhere on the structure, or a pharmaceutically-acceptable salt thereof and certain novel benzo[a]phenothiazines, which compositions and compounds are useful in treating allergic conditions, asthma, cardiovascular disorders, inflammation and pain and are useful as cytoprotective agents.

Abstract: Quino-benzothiazine compounds having the formula ##STR1## wherein R.sub.2 is one or more constituents; R.sub.1 is a hydrogen or a carboxy-protecting group; and Z is an amine group or an aliphatic heterocyclic group. The compounds have antibacterial activity.

Abstract: 1-pyridine substituted quino-benzothiazine having the formula: ##STR1## wherein X is halogen or hydrogen; R.sub.2 is a substituent; and R.sub.1 is hydrogen or a carboxy protecting group.

Abstract: 1,2-methylenedioxy quino-benzothiazine derivatives having the formula ##STR1## wherein R.sub.2 is a substituent and R.sub.1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity.

Abstract: The novel compound according to the present invention, viz. 3,4-dihydropyrrolo-[1,2-a]-pyrazine has the formula: ##STR1## The method of preparing this compound comprises reacting dialkylacetals or dioxalane of a 2,5-dialkoxytetrahydrofurfurol with ethylenediamine in a medium of lower aliphatic acids at a temperature within the range of from 100.degree. to 150.degree. C., followed by isolation of the desired product.The novel compound according to the present invention, viz. 3,4-dihydropyrrolo-[1,2-a]-pyrazine, owing to a simple method for producing same, simplifies the process of manufacture of physiologically active compounds employed in neuroleptic or coronary dilating preparations, wherein it may be used as the starting material.