Polycyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos Patents (Class 544/14)
  • Patent number: 10494373
    Abstract: Disclosed is a fused-ring or tricyclic aryl pyrimidine compound used as a mutation selectivity EGFR inhibitor. Specifically, disclosed is a compound represented by formula (I) and used as an EGFR inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: December 3, 2019
    Assignee: Guangdong Zhongsheng Pharmaceutical Co., Ltd
    Inventors: Charles Z. Ding, Shuhui Chen, Baoping Zhao, Xile Liu, Linxia Xiao, Chao Ding, Fei Wang, Jian Li
  • Patent number: 10101514
    Abstract: Provided is a laminate comprising a thermoplastic resin substrate and a polyvinyl alcohol based resin layer formed on the thermoplastic resin substrate, being used to form a polarizing film of the polyvinyl alcohol based resin layer treated with a post-process comprising at least a dyeing step of dyeing the polyvinyl alcohol based resin layer with a dichroic material, the post-process being performed after the polyvinyl alcohol based resin layer formed on the thermoplastic resin substrate is stretched together with the thermoplastic resin substrate, wherein the polyvinyl alcohol based resin layer comprises a polyvinyl alcohol based resin and a halide.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: October 16, 2018
    Assignee: NITTO DENKO CORPORATION
    Inventors: Shusaku Goto, Minoru Miyatake, Takashi Kamijo, Satoru Kunikata
  • Patent number: 10079346
    Abstract: The present invention provides compounds of formula (I) wherein X is O, S or NR10, wherein R10 is H, C1-30-alkyl, substituted C1-30-alkyl, C2-30-alkenyl, substituted C2-30-alkenyl, C2-30-alkynyl, substituted C2-30-alkynyl or C(0)-OR11, R1 and R11 are independently from each other selected from the group consisting of C1-30-alkyl, substituted C1-30-alkyl, C2-30-alkenyl, substituted C2-30-alkenyl, C2-30-alkynyl, substituted C2-30-alkynyl, C5-8-cycloalkyl, substituted C5-8-cycloalkyl, C5-8-cycloalkenyl, and substituted C5-8-cycloalkenyl, and an electronic device comprising the compounds as semiconducting material.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: September 18, 2018
    Assignee: BASF SE
    Inventors: Hitoshi Yamato, Takuya Tsuda, Chao Wu, Thomas Weitz, Michael Eustachi, Maximilian Hemgesberg
  • Patent number: 9899605
    Abstract: An organic thin film transistor containing a compound represented by the formula (1) in a semiconductor active layer has a high carrier mobility, a small change in the threshold voltage after repeated driving and a high solubility in an organic solvent. A1 and A2 represent S, O or Se; at least one of R1 to R6 represents a substituent represented by *-L-R wherein L represents a divalent linking group and R represents a hydrogen atom, an alkyl group, an oligooxyethylene group, an oligosiloxane group or a trialkylsilyl group.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: February 20, 2018
    Assignee: FUJIFILM Corporation
    Inventors: Yasunori Yonekuta, Koji Takaku, Wataru Sotoyama
  • Patent number: 9062077
    Abstract: This invention relates to the field of biologically active compounds and specifically to phaeofungins, of the general formula (I) or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof, pharmaceutical compositions comprising these compounds, methods for the production of the phaeofungins and their use as fungicide, antibiotic as well as antitumor agent.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: June 23, 2015
    Assignee: Leibniz-Institut fuer Naturstoff-Forschung und Infektionsbiologie E.V. Hans-Knoell-Institute (HKI)
    Inventors: Axel Brakhage, Hans-Martin Dahse, Christian Hertweck, Hans-Wilhelm Nuetzmann, Kirstin Scherlach
  • Publication number: 20150034887
    Abstract: A novel photochromic compound which develops a color of a neutral tint (double peak characteristic) and has high color optical density, high fading speed and excellent durability. Like a compound represented by the following formula (20), the photochromic compound having a group (methylthio group in the following formula 20) which has a sulfur atom bonded to the 7-position carbon atom is a photochromic compound having high color optical density, high fading speed and excellent durability.
    Type: Application
    Filed: March 11, 2013
    Publication date: February 5, 2015
    Applicant: TOKUYAMA CORPORATION
    Inventors: Shinobu Izumi, Yasutomo Shimizu, Junji Momoda
  • Publication number: 20140315896
    Abstract: This invention relates to the field of biologically active compounds and specifically to phaeofungins, of the general formula (I) or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof, pharmaceutical compositions comprising these compounds, methods for the production of the phaeofungins and their use as fungicide, antibiotic as well as antitumor agent.
    Type: Application
    Filed: June 15, 2012
    Publication date: October 23, 2014
    Applicant: Leibniz-Institut fuer Naturstoff-Forschung und Infektionsbiologie E.V. Hans-Knoell-Institut (HKI)
    Inventors: Axel Brakhage, Hans-Martin Dahse, Christian Hertweck, Hans-Wilhelm Nuetzmann, Kirstin Scherlach
  • Publication number: 20140303144
    Abstract: Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor ?2B antagonists. The compounds may also bind to and antagonize adrenergic receptor ?2B. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.
    Type: Application
    Filed: February 17, 2012
    Publication date: October 9, 2014
    Applicant: Medivation Technologies, Inc.
    Inventors: Andrew Asher Protter, Sarvajit Chakravarty
  • Publication number: 20140228353
    Abstract: Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic receptor ?2A. The compounds may also bind to and are an antagonist of the adrenergic receptor ?2B; or the compounds are not antagonists of the adrenergic receptor ?2B and the compounds are administered in conjunction with a second agent that reduces, or is expected to reduce, blood pressure in an individual. The compounds may find use in therapy, e.g., to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. Use of the compounds to treat type 2 diabetes is particularly described.
    Type: Application
    Filed: February 17, 2012
    Publication date: August 14, 2014
    Applicant: Medivation Technologies, Inc.
    Inventors: Andrew Asher Protter, Sarvvajit Chakravarty
  • Publication number: 20130313532
    Abstract: [Problem] To provide a charge transporting material which allows for a low driving voltage and is superior in luminous efficiency and durability. [Means for resolution] A charge transporting material comprising a compound represented by any one of the following general formula (1-1) to general formula (1-3): wherein R111 to R114, R121 to R125 and R131 to R135 each independently represent a hydrogen atom or a substituent, and may be bound together to form a ring; L111 to L113 each independently represent O or S; L121 to L123 each independently represent a single bond or a divalent linking group; and Ar111 to Ar113 each independently represent an aryl group or a heteroaryl group.
    Type: Application
    Filed: May 20, 2013
    Publication date: November 28, 2013
    Applicant: UDC IRELAND LIMITED
    Inventors: Kousuke WATANABE, Yosuke YAMAMOTO, Wataru SOTOYAMA
  • Publication number: 20130225558
    Abstract: This disclosure is directed to fused tetracyclic pyrido[4,3-b>]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
    Type: Application
    Filed: February 18, 2011
    Publication date: August 29, 2013
    Inventors: Sarvajit Chakravarty, Barry Patrick Hart, Rajendra Parasmal Jain
  • Publication number: 20130210803
    Abstract: This disclosure is directed to fused tetracyclic pyrido[4,3-b]indoles and pyrido[3,4-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
    Type: Application
    Filed: February 18, 2011
    Publication date: August 15, 2013
    Inventors: Sarvajit Chakravarty, Barry Patrick Hart, Rajendra Parasmal Jain
  • Patent number: 8481785
    Abstract: The invention pertains to new materials based on sterically inhibited donor arylboranes for the improvement of electron injection and electron transport in organic electronic components like organic light-emitting diodes (OLED's), organic field effect transistors (OFET's), and on organic photovoltaics based components, in particular, organic solar cells.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: July 9, 2013
    Assignee: Osram Opto Semiconductors GmbH
    Inventor: Andreas Kanitz
  • Publication number: 20130053555
    Abstract: The present invention relates to electronic devices, in particular organic electroluminescent devices, comprising compounds of the formula (1), and the corresponding compounds.
    Type: Application
    Filed: March 29, 2011
    Publication date: February 28, 2013
    Inventors: Amir Hossain Parham, Christof Pflumm, Philipp Stoessel, Arne Buesing, Dominik Joosten
  • Patent number: 8349992
    Abstract: The present invention provides a thermosetting resin having a benzoxazine ring structure represented by the following formula (I): wherein X is a residue of a diol compound having a molecular weight or a number average molecular weight in terms of polystyrene measured by GPC of 5,000 or less; Y is a residue of a diamine compound; and n is an integer of 2 to 200.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: January 8, 2013
    Assignee: Sekisui Chemical Co., Ltd.
    Inventors: Yuji Eguchi, Kazuo Doyama
  • Publication number: 20120319052
    Abstract: The present invention relates to compounds of the formula (1) or (2) and to the use thereof in electronic devices, and to electronic devices which comprise these compounds. The invention furthermore relates to the preparation of the compounds of the formula (1) or (2) and to formulations comprising one or more compounds of the formula (1) or (2).
    Type: Application
    Filed: January 21, 2011
    Publication date: December 20, 2012
    Applicant: Merck Patent GmbH
    Inventors: Constanze Brocke, Christof Pflumm, Amir Hossain Parham, Rocco Fortte
  • Publication number: 20120214803
    Abstract: The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.
    Type: Application
    Filed: February 2, 2012
    Publication date: August 23, 2012
    Applicant: VIFOR (INTERNATIONAL) AG
    Inventors: Wilm Buhr, Susanna Burckhardt, Franz Dürrenberger, Felix Funk, Peter O. Geisser, Vincent A. Corden, Stephen M. Courtney, Graham Dawson, Tara Davenport, Mark Slack, Mark P. Ridgill, Chrostopher J. Yarnold, Susan Boyce, Albertus A. Ellenbroek
  • Patent number: 8207146
    Abstract: The present invention relates to substituted phenothiazines with a double bond and physiologically acceptable salts thereof, and their use as a medicament.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: June 26, 2012
    Assignee: Sanofi-Aventis
    Inventors: Stefanie Keil, Elisabeth Defossa, Dieter Schmoll, Axel Dietrich, Johanna Kuhlmann-Gottke, Karl-Christian Engel
  • Publication number: 20120122804
    Abstract: The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. The present invention also relates to methods for using such compounds.
    Type: Application
    Filed: March 30, 2007
    Publication date: May 17, 2012
    Applicant: Cylene Pharmaceuticals, Inc.
    Inventors: Jeffrey P. Whitten, Michael Schwaebe, Adam Siddiqui-Jain, Terrance Moran
  • Publication number: 20120070409
    Abstract: The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
    Type: Application
    Filed: February 3, 2011
    Publication date: March 22, 2012
    Applicant: Japan Tobacco Inc.
    Inventors: Takahiro Oka, Kazutaka Ikegashira, Shintaro Hirashima, Hiroshi Yamanaka, Satoru Noji, Yasushi Niwa, Yoko Matsumoto, Toshihiro Sato, Izuru Ando, Yukihiro Nomura
  • Publication number: 20120064099
    Abstract: The present invention relates to compounds with activity as BACE1 and NF?B modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.
    Type: Application
    Filed: April 26, 2011
    Publication date: March 15, 2012
    Applicant: The Trustees of Columbia University in The City of New York
    Inventors: Donald W. Landry, Tae-Wan Kim, Shi Xian Deng, Gangli Gong, Jeremy C. Hwang, Yuli Xie, Yidong Liu, K. Alison Rinderspacher
  • Patent number: 8088500
    Abstract: The invention provides an OLED device including a cathode, an anode, and having there between a light-emitting layer, further including, between the cathode and the light emitting layer, a first layer containing a fluoranthene compound including one and only one fluoranthene nucleus and having no aromatic rings annulated to the fluoranthene nucleus, the fluoranthene nucleus having independently selected aromatic groups in the 7,10-positions and an azine group in the 8- or 9-position, provided that the azine group is not a phenanthroline group. The OLED device desirably includes a second layer containing an alkali metal or alkali metal compound, located between the cathode and the first layer. The OLED device can also include a polycyclic aromatic hydrocarbon compound in the first layer or in a third layer located between the first layer and the light-emitting layer. Devices of the invention provide improvement in features such as efficiency and drive voltage.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: January 3, 2012
    Assignee: Global OLED Technology LLC
    Inventors: William J. Begley, Natasha Andrievsky, Liang-Sheng Liao
  • Patent number: 7943320
    Abstract: The present invention relates to novel unsymmetrical cyanine dyes and to methods of performing nucleic acid analysis in the presence of such dyes. More specifically, the present invention relates to novel unsymmetrical cyanine dyes that have high affinity to double-stranded nucleic acids and that do not inhibit amplification reactions, particularly the polymerase chain reaction (PCR).
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: May 17, 2011
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventor: Weidong Cao
  • Publication number: 20110110948
    Abstract: Disclosed are novel gamma secretase inhibitors of the formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein L1, n, X, Ar, Y, Z, Q, and Q1 are as defined herein. Also disclosed are methods for inhibiting gamma secretase, methods for treating Alzheimer's disease, methods of treating one or more neurodegenerative diseases, and methods of inhibiting the deposition of amyloid protein (e.g., amyloid beta protein) in, on or around neurological tissue (e.g., the brain) using the compounds of formula 1.0.
    Type: Application
    Filed: July 15, 2008
    Publication date: May 12, 2011
    Applicant: SCHERING CORPORATION
    Inventors: Thavalakulamgara K. Sasikumar, Duane A. Burnett, Theodros Asberom, Wen-Lian Wu, Hongmei Li, Ruo Xu, Hubert B. Josien
  • Patent number: 7935685
    Abstract: A process for the preparation of inclusion complexes of a drug (piroxicam or ibuprofen) and a cyclodextrin, characterised in that: a) the drug and cyclodextrin, in the form of finely divided powders, are mixed in the presence of aqueous or hydroalcoholic solutions, ammonia solutions or acid solutions; b) the resulting mixture is treated in a microwave oven; c) the resulting product is dried under vacuum at room temperature or with heating.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: May 3, 2011
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Ferdinando Giordano, Ruggero Bettini
  • Patent number: 7932397
    Abstract: The present invention provides methods for the synthesis of catalysts and precursors thereof. Methods of the invention may comprise combining a catalyst precursor and at least one ligand to generate a catalytically active species, often under mild conditions and in high yields. In some cases, a wide variety of catalysts may be synthesized from a single catalyst precursor. Methods of the invention may also include the preparation of catalysts which, under reaction conditions known in the art, may have been difficult or impossible to prepare and/or isolate due to, for example, steric crowding at the metal center. The present invention also provides catalyst compositions, and precursors thereof, which may be useful in various chemical reactions including olefin metathesis. In some cases, methods of the invention may reduce the number of synthetic and purification steps required to produce catalysts and/or other reaction products, as well as reducing time, cost, and waste production.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: April 26, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Adam S. Hock, Richard R. Schrock
  • Publication number: 20110065687
    Abstract: This application relates to certain novel polycyclic compounds that interact with quadruplex-forming regions of polynucleotides and thereby inhibit translation of genetic information into polypeptides. These compounds can thus provide anticancer and antibacterial and antiviral effects. The invention includes novel compounds and pharmaceutical compositions, and methods of using them to treat cancer and other conditions.
    Type: Application
    Filed: April 17, 2008
    Publication date: March 17, 2011
    Inventors: Michael Schwaebe, Johnny Yasuo Nagasawa, Mustapha Haddach
  • Patent number: 7820653
    Abstract: A photosensing soluble organic semiconductor material is disclosed, which includes a Diels-Alder adduct which is a polycyclic aromatic compound with a dienophile. The polycyclic aromatic compound is pentacene. And the dienophile is represented by the formula of O?S?N—R1, wherein R1 is SO2R2, SO3R2, SO2?, or SO3?; and wherein R2 is selected from the group consisting of alkyl, alkoxy, acyl, aryl, aralkyl, chloroalkyl, fluoroalkyl, and substituted aryl with 1-12 carbon atoms.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: October 26, 2010
    Assignee: Industrial Technology Research Institute
    Inventors: Tarng-Shiang Hu, Hsiang-Yuan Cheng, Jia-Chong Ho, Tzu-Wei Lee, Ming-Chou Chen, Jen-Shyang Ni
  • Patent number: 7799912
    Abstract: A bifunctional compound comprising a molecular unit (I) intercalating between nucleobases (B) of nucleic acids, an active molecular unit (AD) capable of emitting a detectable signal, and optionally a spacer unit, in which the active molecular unit (AD) is selected from amongst chemical entities having a structure such as to interact electronically with the intercalating molecular unit (I) in such a way that, during the reaction of oxidation, the reduction-oxidation potential (EI+/I) of the semicouple I+/I defined by the intercalating molecular unit (I) is lower than the reduction-oxidation potential (EB+/B) of the semicouple B+/B defined by the nucleobases (B), and in such a way that, during the reaction of reduction, the reduction-oxidation potential (EI/I?) of the semicouple I/I? defined by the intercalating molecular unit (I) is higher than the reduction-oxidation potential (EB/B?) of the semicouple B/B? defined by the nucleobases (B).
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: September 21, 2010
    Assignee: STMicroelectronics S.r.l.
    Inventors: Sabrina Conoci, Salvatore Sortino
  • Patent number: 7691847
    Abstract: The present invention provides methods for treating neurological diseases and disorders. Compounds that replace or enhance the function of SMN or alleviate or reduce a phenotype of cells with low SMN protein levels are provided. Screening methods and kits for identifying such compounds also are provided.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: April 6, 2010
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Gideon Dreyfuss, Jin Wang
  • Publication number: 20090114906
    Abstract: New materials for the n-doping of the elctron-transporting layer in organic electronic components, their utilization, and organic electronic components The invention pertains to new materials based on sterically inhibited donor arylboranes for the improvement of electron injection and electron transport in organic electronic components like organic light-emitting diodes (OLED's), organic field effect transistors (OFET's), and on organic photovoltaics based components, in particular, organic solar cells.
    Type: Application
    Filed: August 23, 2006
    Publication date: May 7, 2009
    Applicant: Osram Opto Semiconductors GmbH
    Inventor: Andreas Kanitz
  • Patent number: 7514427
    Abstract: HIV inhibitory compounds of formula: salts and stereoisomers thereof, wherein R1 and R2 are hydrogen or optionally substituted C1-10alkyl; R3 is n is 1, 2 or 3; R3a is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxycarbonyl, aminocarbonyl, C 1-4alkyloxycarbonyl, mono- or di(C1-4alkyl)aminocarbonyl, C1-4alkylcarbonyl, methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het; or R3 is a monocyclic or bicyclic aromatic heterocyclic ring system, wherein one, two, three or four ring members are nitrogen, oxygen and sulfur, and wherein the remaining ring members are carbon atoms; and wherein each of said heterocyclic ring systems may optionally be substituted; X is —NR7—, —O— or —S—; pharmaceutical compositions containing these compounds, methods for preparing these compounds and compositions.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: April 7, 2009
    Assignee: Tibotec Pharmaceuticals, Ltd.
    Inventors: Bart Rudolf Romanie Kesteleyn, Pierre Jean-Marie Raboisson, Wim Van De Vreken, Maxime Francis Jean-Marie Ghislain Canard
  • Publication number: 20090042868
    Abstract: Inhibitors of indoleamine 2,3-dioxygenase (IDO) are provided as are pharmaceutical compositions containing such inhibitors as well as the use of such inhibitors and compositions for the treatment of a condition in a mammalian subject characterized by pathology of the IDO-mediated tryptophan metabolic pathway. Such conditions may involve suppression of T-cell mediated immune response or may directly result from depletion of tryptophan or accumulation of a product of tryptophan degradation. Specific disease conditions include cataracts, age-related yellowing in the eye, neurodegenerative disorders, mood disorders, cancer and various bacterial/viral infections. IDO inhibitors of this invention are substituted naphthalene and anthracene diones. Novel compounds of this invention include the following taurine-substituted naphthaquinone structure.
    Type: Application
    Filed: July 13, 2005
    Publication date: February 12, 2009
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Raymond J. ANDERSEN, Alban PEREIRA, Xin-Hui HUANG, Grant MAUK, Eduardo VOTTERO, Michel ROBERGE, Aruna BALGI
  • Publication number: 20080305082
    Abstract: Disclosed are compounds having Formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, A, and B are as defined herein, for use in methods for treating, preventing or ameliorating hyperproliferative disorders, such as cancer and other diseases and conditions. The invention also relates to pharmaceutical compositions and formulations comprising a compound having Formula I, and in combination with one or more other active agents and/or treatments.
    Type: Application
    Filed: September 14, 2005
    Publication date: December 11, 2008
    Inventors: John G. Curd, Robert L. Capizzi, John F.W. Keana
  • Publication number: 20080119646
    Abstract: A process for the preparation of substituted benzothiazinoindoles of general formula (I) wherein R1, R2, and R4 are independently selected from hydrogen, chloro, fluoro, amino, nitro, cyano, CHO, (C1-C3)alkyl, perhalo(C1-C3)alkyl, (C1-C3)alkoxy, aryl, aralkyl, aralkoxy, (C5-C7)heterocyclyl, (C5-C7)heterocyclylalkyl, (C5-C7)heterocyclyloxy, acyl, acetyl, alkylamino, aminoalkyl, amide, hydroxyalkyl, carboxylic acid and its derivatives. The process comprises cyclization of compound of general formula-II (i.e. substituted 1-benzenesulfonyl-7-bromo-1H-indole), formula (II) wherein R1, R2, R3 and R4 are attached using suitable catalyst and solvents.
    Type: Application
    Filed: June 23, 2005
    Publication date: May 22, 2008
    Inventors: Venkata Satya Niroai Ramakrishna, Vikas Shreekrishna Shirsath, Rama Sastri Kambhampati, Amol Dinkar Deshpande, Prabhakar Kothmirkar, Venkateswarlu Jasti
  • Publication number: 20070262298
    Abstract: A photosensing soluble organic semiconductor material is disclosed, which includes a Diels-Alder adduct which is a polycyclic aromatic compound with a dienophile. The polycyclic aromatic compound is selected from the group consisting of oligothiophene, perylene, benzo[ghi]perylene, coronene and polyacene. And the dienophile is represented by the formula of O?S?N—R1, wherein R1 is SO2R2, SO3R2, SO2?, or SO3?; and wherein R2 is selected from the group consisting of alkyl, alkoxy, acyl, aryl, aralkyl, chloroalkyl, fluoroalkyl, and substituted aryl with 1-12 carbon atoms.
    Type: Application
    Filed: October 26, 2006
    Publication date: November 15, 2007
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Tarng-Shiang Hu, Hsiang-Yuan Cheng, Jia-Chong Ho, Tzu-Wei Lee, Ming-Chou Chen, Jen-Shyang Ni
  • Patent number: 7125989
    Abstract: The present invention describes organic solvent-soluble Diels-Alder adducts of polycyclic aromatic compounds, such as, oligothiophene, perylene, benzo[ghi]perylene, coronene and polyacenes, with variety of dienophiles containing at least one heteroatom and in some cases two heteroatoms bonded to aromatic moiety, such as, thioxomalonates, azodicarboxylates, thialdehyde, acylnitroso and N-sulfinylamides. The Diels-Alder adducts are prepared by a simple, one step cycloaddition reaction of the polycyclic aromatic compounds, such as, pentacene, or other fused aromatic compounds, with heterodienophiles. The Diels-Alder adducts according to the present invention all form soluble adducts with pentacene and can be converted back to pentacene by retro-Diels-Alder reaction at moderate (60–250° C.) temperatures both in bulk, in solution or as thin-films.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: October 24, 2006
    Assignee: International Business Machines Corporation
    Inventors: Ali Afzali-Ardakani, Tricia L Breen, Christos D Dimitrakopoulos
  • Patent number: 7026475
    Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, n, and m, are as defined herein, or an enantiomer or diastereomer thereof, or a pharmacologically acceptable salt thereof, processes for preparing these compounds, and their use in pharmaceutical compositions.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: April 11, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Angelo Ceci, Klaus Klinder, Thomas Weiser, Karin Winter
  • Patent number: 7008941
    Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, B, X, R1, and R5 are as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents as well as inhibitors of central nervous disorders. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: March 7, 2006
    Assignee: Myriad Genetics, Inc.
    Inventors: Jan Urban, Hiroshi Nakanishi, Min S. Lee
  • Patent number: 6900204
    Abstract: The invention features compounds that act as antimicrobial agents and/or antimicrobial enhancer agents, compositions that include the antimicrobial enhancer agents of the invention, and methods for treating microbial infections using those compositions.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: May 31, 2005
    Assignee: ActivBiotics, Inc.
    Inventors: Arthur F. Michaelis, Hawkins V. Maulding
  • Publication number: 20040266758
    Abstract: Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure 1
    Type: Application
    Filed: June 10, 2004
    Publication date: December 30, 2004
    Inventors: Sara Sabine Hadida-Ruah, Xiaohui He, Johnny Yasuo Nagasawa
  • Publication number: 20040215015
    Abstract: Sulfoderivatives of perylenetetracarboxylic acid dibenzimidazole are provided. These compounds form liquid crystal systems possessing high quality optical properties. The resulting liquid crystal systems are readily applicable onto a substrate to obtain optically isotropic or anisotropic, at least partially crystalline films applicable in various fields.
    Type: Application
    Filed: November 14, 2003
    Publication date: October 28, 2004
    Inventors: Victor V. Nazarov, Elena N. Sidorenko
  • Patent number: 6800618
    Abstract: A compound having the structural formula or a pharmaceutically acceptable salt or prodrug thereof, wherein X is a substituted or unsubstituted alkyl or a heteroatom; n is 4, 5 or 6; Y is a substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or wherein R1 and R2 are each independently, H, a heteroatom, substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; and wherein each ring structure are independently substituted or unsubstituted is disclosed. Also disclosed are chemosensitizing agents and methods of modulating, attenuating, reversing, or affecting a cell's or organism's resistance to a given drug such as an antimalarial.
    Type: Grant
    Filed: May 7, 2001
    Date of Patent: October 5, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Ai J. Lin, Jian Guan, Dennis E. Kyle, Wilbur K. Milhous
  • Patent number: 6777406
    Abstract: The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein is R1, R6a, R6b, R7, R8, R9, X, b, m, and n are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: August 17, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: John M. Fevig, Ian S. Mitchell, Taekyu Lee, Wenting Chen, Joseph Cacciola
  • Publication number: 20040157831
    Abstract: The present invention provides compounds of Formula (I): 1
    Type: Application
    Filed: February 3, 2004
    Publication date: August 12, 2004
    Applicant: Pharmacia & Upjohn Company
    Inventor: William W. McWhorter
  • Publication number: 20040127492
    Abstract: Cyclic pyrazole compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of making such compounds are described, as well as a method of using them for the inhibition of MK-2 in a subject in need of such inhibition, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.
    Type: Application
    Filed: February 18, 2003
    Publication date: July 1, 2004
    Applicant: Pharmacia Corporation
    Inventors: Michael L. Vazquez, Suzanne Metz, Matthew J. Graneto, Cathleen E. Hanau, Serena Marie Mershon, Susan J. Hartmann, David B. Reitz, Gennadiy Poda, Len F. Lee, Thao D. Perry, Emily J. Reinhard, Leslie Pugh
  • Publication number: 20040122002
    Abstract: The present invention relates to fused pyrrole compounds of the formula 1.
    Type: Application
    Filed: September 27, 2002
    Publication date: June 24, 2004
    Inventors: Hans Guenter Striegel, Stefan Laufer, Karola Tollmann, Susanne Tries
  • Publication number: 20040092514
    Abstract: The present invention provides compounds of Formula I or II that are useful as anti-cancer agents and other diseases that can be treated by inhibiting tyrosine kinase enzymes.
    Type: Application
    Filed: September 29, 2003
    Publication date: May 13, 2004
    Inventors: Upender Velaparthi, Mark D. Wittman
  • Publication number: 20040092502
    Abstract: The present invention is directed to certain novel compounds represented by structural Formula (I) 1
    Type: Application
    Filed: December 19, 2001
    Publication date: May 13, 2004
    Inventors: John M. Fevig, Ian S. Mitchell, Taekyu Lee, Wenting Chen, Joseph Cacciola
  • Patent number: RE39679
    Abstract: The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8, R9, X, b, k, m, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: June 5, 2007
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Albert J. Robichaud, Taekyu Lee, Wei Deng, Ian S. Mitchell, Michael Guang Yang, Simon Haydar, Wenting Chen, Christopher D. McClung, Emile J. B. Calvello, David M. Zawrotny, Parthasarathl Rajagopalan