1,2- Or 2,1-thiazine Ring In The Tricyclo Ring System (e.g., Hydrogenated 1,2-benzothiazine In Tricyclo Ring System, Etc.) Patents (Class 544/33)
  • Patent number: 4137313
    Abstract: Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is methyl or ethyl;Y is hydrogen, fluorine, chlorine, bromine, methoxy, methyl, ethyl or trifluoromethyl; andAr is 2-thiazolyl which may have one or two methyl or ethyl substituents attached thereto; 5,6-dihydro-4H-cyclopentathiazol-2-yl; 4,5,6,7-tetrahydro-2-benzothiazolyl; 2-benzothiazolyl; 3-isothiazolyl which may have a methyl substituent attached thereto; 2-pyridyl which may have a methyl or hydroxyl substituent attached thereto; 3-pyridyl; 4-pyridyl; 4-pyrimidinyl; pyrazinyl; 2-benzimidazolyl; 2-oxazolyl which may have a methyl substituent attached thereto; 2-benzoxazolyl; or phenyl which may have a fluoro, chloro, bromo, methyl, ethyl, trifluoromethyl or methoxy substituent attached thereto; and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antiphlogistics and blood platelet aggregation inhibitors.
    Type: Grant
    Filed: January 27, 1978
    Date of Patent: January 30, 1979
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Gunter Trummlitz, Wolfhard Engel, Ernst Seeger, Walter Haarmann, Gunther Engelhardt