Nitrogen Attached Indirectly To The Piperazine Ring By Nonionic Bonding Patents (Class 544/402)
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Publication number: 20030144505Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof: 1Type: ApplicationFiled: January 16, 2003Publication date: July 31, 2003Applicant: SmithKline Beecham p.l.c.Inventors: Steven Mark Bromidge, Francis David King, Paul Adrian Wyman
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Patent number: 6593473Abstract: Improved process for the preparation of granular N-alkylammoniumacetonitrile salts I R2R3N+R1—CR4R5—CN Y− (I) where R1 to R5 are hydrogen or organic radicals, and Y− is a sulfate or hydrogensulfate anion, from an aqueous solution of the compound II R2R3N+R1—CR4R5—CN R6O—SO2—O− (II) where R6 is C1- to C4-alkyl, which comprises evaporating this aqueous solution at a temperature of from 80° C. to 250° C. and a pressure of from 10 mbar to 2 bar to give a melt, then allowing the melt to solidify, where, during or following the evaporation, customary carrier materials and/or auxiliaries can be added, and the resulting solidified compound I is converted into the desired granular form.Type: GrantFiled: September 25, 2001Date of Patent: July 15, 2003Assignee: BASF AktiegesellschaftInventors: Michael Schönherr, Hans-Jürgen Kinder, Klaus Mundinger, Gregor Schürmann
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Publication number: 20030119721Abstract: A class of compounds is described which can be used for the treatment of viral infections.Type: ApplicationFiled: November 25, 2002Publication date: June 26, 2003Applicant: G. D. Searle & Co., Corporate Patent DepartmentInventors: Daniel L. Flynn, Jeffery Zablocki, Kenneth Williams, Susan L. Hockerman
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Publication number: 20030120066Abstract: The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl gorup and 6-8 atoms in the ring is disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.Type: ApplicationFiled: June 6, 2002Publication date: June 26, 2003Inventors: Adel Nefzi, John M. Ostresh, Richard A. Houghten
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Publication number: 20030105161Abstract: There are provided novel compounds of formula (I), 1Type: ApplicationFiled: August 22, 2002Publication date: June 5, 2003Inventors: Tim Birkinshaw, David Cheshire, Antonio Mete
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Publication number: 20030105092Abstract: Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.Type: ApplicationFiled: September 26, 2002Publication date: June 5, 2003Inventors: Kimberley Q. Cameron, Hua Z. Ke, Bruce A. Lefker, Robert L. Rosati, David D. Thompson
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Publication number: 20030105079Abstract: The present invention relates to novel 1,2- or 1,3-diamine and amide compounds and pharmaceutically useful salts thereof and methods for treating central nervous system diseases. The present 1,2- or 1,3-diamine and amide compounds have high binding affinity to the sigma receptor.Type: ApplicationFiled: June 12, 2002Publication date: June 5, 2003Inventors: Yong-Moon Choi, Yong-Kil Kim, Chun-Eung Park, Eun-Ho Lee
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Publication number: 20030087890Abstract: The present application describes novel 1,2-disubsituted cyclic derivatives of formula I: 1Type: ApplicationFiled: January 9, 2002Publication date: May 8, 2003Inventors: Chu-Biao Xue, Carl Decicco, Xiaohua He
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Publication number: 20030078428Abstract: Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.Type: ApplicationFiled: June 4, 2002Publication date: April 24, 2003Inventors: Stephen Douglas Barrett, Alexander James Bridges, Annette Marian Doherty, David Thomas Dudley, Alan Robert Saltiel, Haile Tecle
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Patent number: 6552025Abstract: Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The preferred derivative is 2,6-bis-(&ohgr;-aminobutyl)-3,5-diimino-piperazine. This is a naturally occurring biochemical compound isolated from cells. The diimino-piperazine derivatives are useful as therapeutic agents when administered to patients to treat diseases and disorders involving cell regulation.Type: GrantFiled: November 17, 2000Date of Patent: April 22, 2003Assignee: Emory UniversityInventors: Alfred H. Merrill, Jr., Lisa Warden, Dennis C. Liotta
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Patent number: 6548504Abstract: The present invention therefore provides, in a first aspect, a compound of formula (I) or a salt thereof: in which the group D is selected from a group of formula (A), (B) or (C) below: in which P is a monocyclic, bicyclic or tricyclic alicyclic ring containing up to 20 carbon atoms in the ring(s); A is a single bond, a C1-6alkylene or a C2-6alkenylene group; R1 is halogen, C1-6alkyl optionally substituted by one or more fluorine atoms, C3-6cycloalkyl, C1-6alkoxy, OCF3, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, C1-6alkanoyl, amino, alkylamino or dialkylamino, SR11 where R11 is hydrogen or C1-6alkyl or R1 is aryl, arylC1-6alkyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulfur; n is 0, 1, 2 or 3; and R2 is hydrogen, C1-6alkyl, aryl, arylC1-6alkyl or C3-6cycloalkyl; or in which Ra is an alkyl group containing 1 to 20 carbon atoms oType: GrantFiled: July 19, 2000Date of Patent: April 15, 2003Assignee: SmithKline Beecham p.l.c.Inventors: Steven Mark Bromidge, Stephen Frederick Moss
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Patent number: 6548498Abstract: The present invention relates to new piperidyl- or piperazinyl-substituted indan derivatives of the formula I as (R)-enantiomers, (S)-enantiomers, or racemates in the form of a free base or pharmaceutically acceptable salts or solvates thereof. The present invention further relates to a process for the preparation of the compounds, to pharmaceutical compositions containing the compounds and to methods of treatment of 5-hydroxytryptamine-mediated disorders comprising administering the compounds.Type: GrantFiled: October 21, 1998Date of Patent: April 15, 2003Assignee: AstraZeneca ABInventors: Stefan Berg, Lennart Florvall, Svante Ross, Seth-Olov Thorberg
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Publication number: 20030069234Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.Type: ApplicationFiled: June 6, 2002Publication date: April 10, 2003Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus
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Patent number: 6541632Abstract: A carbocyclic or heterocyclic compound, ammonia and an oxygen-containing gas are subjected to fluid catalytic reaction in vapor phase in the presence of a catalyst containing alkali metal to produce an aromatic or heterocyclic nitrile. The use of the catalyst containing a specific amount of alkali metal enables the stable production of the aromatic or heterocyclic nitrile in high yields with little change with time even when water is present in the reaction system. The use of the catalyst containing the alkali metal also enables the recycle and reuse of unreacted ammonia which is usually accompanied by water, thereby reducing production costs.Type: GrantFiled: June 19, 2002Date of Patent: April 1, 2003Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Hideaki Ogino, Takashi Okawa, Shuji Ebata, Yoshinori Kanamori
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Publication number: 20030032802Abstract: This invention relates to the novel use of dianilino squarates in the treatment of disease states mediated by the chemokine, Interteukin-8 (IL-8).Type: ApplicationFiled: August 30, 2002Publication date: February 13, 2003Inventors: Michael R. Palovich, Joseph Weinstock, Katherine L. Widdowson
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Publication number: 20030013846Abstract: Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e.g., polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.Type: ApplicationFiled: May 3, 2002Publication date: January 16, 2003Inventors: Bing Wang, Guy Miller, Satyanarayana Janagani, Wei Zhang
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Patent number: 6506759Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.Type: GrantFiled: October 31, 2000Date of Patent: January 14, 2003Assignee: Monsanto CompanyInventors: John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Kathryn L. Reed, Ko-Chung Lin, John Nicholas Freskos, Michael Clare, Donald Joseph Rogier, Jr., Robert M. Heintz, Michael L. Vazquez, Richard A. Mueller
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Publication number: 20030009029Abstract: The present invention relates to a process preparing compounds of the general formula (I) 1Type: ApplicationFiled: June 5, 2002Publication date: January 9, 2003Applicant: Merck Patent GmbHInventors: Herwig Buchholz, Urs Welz-Biermann
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Patent number: 6503910Abstract: Compounds of the formula (B)2N—X—(CH2)n—CR1R2—CO—Y (I) have therapeutic utility as inhibitors of metalloproteinases etc.Type: GrantFiled: August 11, 2000Date of Patent: January 7, 2003Assignee: Darwin Discovery Ltd.Inventors: Andrew Douglas Baxter, David Alan Owen, Robert John Watson, John Gary Montana
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Patent number: 6495546Abstract: Propanolamine derivatives represented by the following formula (I): These derivatives may be &bgr;3 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria activities. Pharmaceutical compositions containing such propanolamine derivatives, methods for the prevention and/or treatment diseases using these propanolamine derivatives, and processes for their preparation are also described.Type: GrantFiled: November 22, 2000Date of Patent: December 17, 2002Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Minoru Sakurai, Naoaki Fujii, Kumi Hosoi, Yasuyo Tomishima, Hisashi Takasugi, Hajime Sogabe, Hirofumi Ishikawa, Naomi Hanioka
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Patent number: 6489327Abstract: The invention relates to novel inhibitors of human tryptase which are used in the pharmaceutical industry for the production of medicaments.Type: GrantFiled: October 20, 2000Date of Patent: December 3, 2002Assignees: Max-Planck-Gesellschaft zur Fordrungder Wisenschaften, e.V., Byk Gulden Lomberg Chemische Fabrik GmbHInventors: Thomas Bär, Thomas Martin, Josef Stadlwieser, Wolf-Rüdiger Ulrich, Andreas Dominik, Ulrich Thibaut, Daniela Bundschuh, Rolf Beume, Karl-Josef Goebel, Wolfram Bode, Luis Moroder, Pedro Jose Barbosa Pereira, Andreas Bergner, Robert Huber, Christian Sommerhoff, Norbert Schaschke
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Publication number: 20020177598Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.Type: ApplicationFiled: November 29, 2000Publication date: November 28, 2002Applicant: Schering AktiengschellschaftInventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
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Patent number: 6472397Abstract: The compounds represented by the formula (I), and pharmacologically acceptable salts and solvates thereof are disclosed. The compound is hydrolyzed in organisms into a compound represented by the formula in which W represents a hydrogen atom, and D represents the group —V—(CH2)p—COOR, wherein R represents a hydrogen atom. The compound inhibits the aggregation of platelets via the inhibition of the linkage of the platelet membrane protein GPIIb/IIIa to fibrinogen. wherein A represents CH2 or CO, B represents the group —(CH2)k— or —(CH2)m—CO—, X and Y are different from each other and represent N or CH, W represents an ester moiety which can be removed under the physiological condition, and Z represents the groups (II) or (III): wherein D represents the group —V—(CH2)p—COOR.Type: GrantFiled: November 3, 2000Date of Patent: October 29, 2002Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kazumi Ota, Kazuko Kobayashi, Tomoaki Miura, Takahiro Imai, Kazumasa Aizawa, Hisashi Suzuki, Shokichi Ohuchi, Kiyoaki Katano, Takashi Ando
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Patent number: 6472364Abstract: The present invention relates to detergent compositions or components comprising certain cyclic amine based polymers and certain anionic cellulose materials. This combination imparts improved appearance and integrity benefits to fabrics and textiles laundered in washing solutions formed from such compositions, while also providing improved whiteness and/or brightness maintenance.Type: GrantFiled: April 12, 2001Date of Patent: October 29, 2002Assignee: The Procter & Gamble CompanyInventor: Gabor Heltovics
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Publication number: 20020103205Abstract: Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) 1Type: ApplicationFiled: July 11, 2001Publication date: August 1, 2002Inventors: Derek Lowe, Wei Chang, Joseph Kozlowski, Joel G. Berger, Robert McQuade, Allen Barnett, Margaret Sherlock, Wing Tom, Sundeep Dugar, Lian-Yong Chen, John W. Clader, Samuel Chackalamannil, Wang Yuguang, Stuart W. McCombie, Jayaram R. Tagat, Susan F. Vice, Wayne Vaccaro, Michael J. Green, Margaret E. Browne, Theodros Asberom
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Patent number: 6420560Abstract: This invention relates to novel multibinding compounds (agents) that are H1 histamine receptor antagonists and pharmaceutical compositions comprising such compounds. Accordingly, the multibinding compounds and pharmaceutical compositions of this invention are useful in the treatment and prevention of allergic diseases such as rhinitis, urticaria, asthma, and anaphylaxis, and the like.Type: GrantFiled: June 7, 1999Date of Patent: July 16, 2002Assignee: Theravance, Inc.Inventors: Robert P. Numerof, Yu-Hua Ji, John H. Griffin
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Patent number: 6413987Abstract: The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as dermal and topical anesthetics in mammals, including man, as well as compositions containing said compounds.Type: GrantFiled: June 6, 2000Date of Patent: July 2, 2002Assignee: Bridge Pharma, Inc.Inventors: A. K. Gunnar Aberg, George E. Wright, Jan L. Chen
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Patent number: 6403595Abstract: The present invention is to provide a compound or a salt thereof represented by the formula: wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, the ring A is an optionally substituted divalent nitrogen-containing heterocyclic group, X′ is an optionally substituted alkylene chain, Y is an optionally substituted divalent cyclic group, X is a chemical bond or an optionally substituted alkylene chain, and Z is (1) an optionally substituted amino group, (2) an optionally substituted imidoyl group or (3) an optionally substituted nitrogen-containing heterocyclic group, or a pro-drug thereof, which have activated coagulation factor X inhibitory activity and which are useful as anti-coagulants.Type: GrantFiled: August 3, 2000Date of Patent: June 11, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroyuki Tawada, Fumio Itoh, Hiroshi Banno, Zen-ichi Terashita
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Patent number: 6369225Abstract: Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.Type: GrantFiled: August 29, 2000Date of Patent: April 9, 2002Assignee: Allergan Sales, Inc.Inventors: Jayasree Vasudevan, Alan T. Johnson, Dehua Huang, Roshantha A. Chandraratna
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Patent number: 6339154Abstract: A (2-substituted oxyphenyl)alkanamide derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C3-30 expressed by R1 and the other is —(CH2)n—NR2R3; Z is —CO— or —CONR6—; R2 and R3 individually represent H, lower alkyl or benzyl, or —NR2R3 may be a heterocycle having 3-7 members; wherein —CONR5—(CH2)n—NR2R3 or —CONR6—(CH2)n—NR2R3 may be the following Group (D): wherein ring Y is a heterocycle of 6 or 7 members; R4 is selected from the group consisting of H, halogen, lower alkyl, lower acyl and etc; R5 and R6 are individually H, lower alkyl, lower acyl or lower alkylcarbamoyl, or may form a part of said Group(II); 1 is 0 or 1; m is 1 or 2; and n is an integer of 0-5.Type: GrantFiled: February 1, 2000Date of Patent: January 15, 2002Assignee: Shiseido Co, Ltd.Inventors: Koji Kobayashi, Hirotada Fukunishi, Tokuro Iwabuchi
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Patent number: 6335445Abstract: A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of and the other substituents are defined in the specification having an inhibitory activity of NO-synthase enzymes producing nitrogen mono-oxide and/or an activity which traps the reactive oxygen species.Type: GrantFiled: December 7, 1999Date of Patent: January 1, 2002Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auguet, Jeremiah Harnett
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Publication number: 20010056090Abstract: One aspect of the present invention relates to novel heterocyclic compounds comprising urea functionality. A second aspect of the present invention relates to the use of the novel heterocyclic compounds comprising urea functionality as ligands for various cellular receptors, including opioid receptors, other G-protein-coupled receptors and ion channels. An additional aspect of the present invention relates to the use of the novel heterocyclic compounds comprising urea functionality as analgesics.Type: ApplicationFiled: February 23, 2001Publication date: December 27, 2001Inventors: Brian M. Aquila, Gregory D. Cuny, James R. Hauske, Liming Shao, Xinhe Wu
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Patent number: 6300499Abstract: Phenylpiperazine derivatives having high affinity for the &agr;1-adrenoreceptor and pharmaceutical compositions containing them. Also disclosed is a method of using the such derivatives to treat benign prostatic hyperplasia.Type: GrantFiled: September 28, 1998Date of Patent: October 9, 2001Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Dennis Bigg, Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Michel Auguet
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Patent number: 6281206Abstract: Amidino and benzamidino compounds, including compounds of the formula: wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.Type: GrantFiled: February 11, 2000Date of Patent: August 28, 2001Assignee: 3-Dimensional Pharmaceuticals, Inc.Inventors: Tianbao Lu, Bruce E. Tomczuk, Carl R. Illig, Richard M. Soll
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Patent number: 6251846Abstract: Detergent compositions and fabric conditioning compositions which utilize certain anionically modified, oxidized cyclic amine based polymers, oligomers or copolymer materials. These anionically modified, cyclic amine based polymers, oilgomers or copolymers materials can impart fabric appearance and integrity benefits to fabrics and textiles laundered in washing solutions which contain such materials.Type: GrantFiled: March 14, 2000Date of Patent: June 26, 2001Assignee: The Procter & Gamble CompanyInventors: Rajan Keshav Panandiker, Sherri Lynn Randall, Eugene Paul Gosselink, William Conrad Wertz, Soren Hildebrandt, Elisabeth Kappes, Dieter Boeckh
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Patent number: 6235218Abstract: A process is provided for the preparation of a compound having the structure of Formula I The process includes reacting a heterocyclic amine with a monoaldehyde or a dialdehyde in a pH range of from about 8 to 14 and then quaternizing the so-reacted heterocyclic amine with an alkylating agent at a pH of not less than about 2. The use of pH control substantially prevents formation of an undesirable protonated reaction intermediate.Type: GrantFiled: November 19, 1999Date of Patent: May 22, 2001Assignee: The Clorox CompanyInventors: Ulrich Annen, James E. Deline, Lafayette D. Foland, Kevin A. Klotter, Josef Müller, Michael Müller, Klaus Mundinger, Martin A. Phillippi, Alfred Ruland, Wolfgang Schäfer, Gregor Schürmann, Rudi Widder, Alfred G. Zielske
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Patent number: 6228828Abstract: Detergent compositions and fabric conditioning compositions which utilize certain anionically modified, oxidized cyclic amine based polymers, oligomers or copolymer materials. These anionically modified, cyclic amine based polymers, oilgomers or copolymers materials can impart fabric appearance and integrity benefits to fabrics and textiles laundered in washing solutions which contain such materials.Type: GrantFiled: March 14, 2000Date of Patent: May 8, 2001Assignee: The Procter & Gamble CompanyInventors: Rajan Keshav Panandiker, Sherri Lynn Randall, Eugene Paul Gosselink, William Conrad Wertz, Soren Hildebrandt, Elisabeth Kappes, Dieter Boeckh
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Patent number: 6221898Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.Type: GrantFiled: August 29, 1997Date of Patent: April 24, 2001Assignee: Astra AktiebolagInventor: Thomas Antonsson
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Patent number: 6180784Abstract: The present invention provides a process of transfecting a cell with a polynucleotide mixed with one or more amphipathic compounds and an effective amount of a DNA-binding protein. Exemplary and preferred DNA-binding proteins are H1, H2A, and H2B. Exemplary and preferred amphipathic compounds are cationic amphipathic compounds.Type: GrantFiled: January 17, 1998Date of Patent: January 30, 2001Assignee: Mirus CorporationInventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Jeffery Fritz
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Patent number: 6124297Abstract: .alpha.-Unsaturated amines of the formula: ##STR1## wherein X.sup.1 and X.sup.2 are such that one is an electron-attracting group with the other being a hydrogen atom or an electron-attracting group; R.sup.1 is a group attached through a nitrogen atom; R.sup.2 is a hydrogen atom or a group attached through a carbon, nitrogen or oxygen atom; n is an integer equal to 0, 1 or 2; A is a heterocyclic group or a cyclic hydrocarbon group, and salts thereof and their agrochemical use as insecticidal and/or miticidal agents are described.Type: GrantFiled: January 11, 1999Date of Patent: September 26, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Isao Minamida, Koichi Iwanaga, Tetsuo Okauchi
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Patent number: 6107337Abstract: A compound of the formula ##STR1## wherein n, X, R.sup.3, R.sup.4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, bone resorption, loosening of artificial joint implants, atherosclerosis, multiple sclerosis, occular angiogenisis and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF.Type: GrantFiled: August 6, 1998Date of Patent: August 22, 2000Assignee: Pfizer Inc.Inventor: Ralph P. Robinson
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Patent number: 6010994Abstract: The invention provides liquid cleaning or bleaching compositions containing compounds having the structure of Formula I ##STR1## wherein A is a saturated ring formed by five atoms in addition to the N.sub.1 atom, the five saturated ring atoms being four carbon atoms and a heteroatom, the substituent R.sub.1 bound to the N.sub.1 atom of the Formula I structure including either (a) a C.sub.1-24 alkyl or alkoxylated alkyl where the alkoxy is C.sub.2-4, (b) a C.sub.4-24 cycloalkyl, (c) a C.sub.7-24 alkaryl, (d) a repeating or nonrepeating alkoxy or alkoxylated alcohol, where the alkoxy unit is C.sub.2-4, or (e) --CR.sub.2 R.sub.3 CN where R.sub.2 and R.sub.3 are each H, a C.sub.1-24 alkyl, cycloalkyl, or alkaryl, or a repeating or nonrepeating alkoxyl or alkoxylated alcohol where the alkoxy unit is C.sub.2-4, the R.sub.2 and R.sub.3 substituents are each H, a C.sub.1-24 alkyl, cycloalkyl, or alkaryl, or a repeating or nonrepeating alkoxyl or alkoxylated alcohol where the alkoxy unit is C.sub.Type: GrantFiled: November 29, 1996Date of Patent: January 4, 2000Assignee: The Clorox CompanyInventors: Clement K. Choy, James E. Deline, Lafayette D. Foland, Aram Garabedian, Jr., Kevin A. Klotter, Michael J. Petrin, Martin J. Phillippi, William L. Smith
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Patent number: 5985881Abstract: The invention relates to new compounds of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein A, B, Z, R.sup.1, R.sup.2, R.sup.3 and m are defined as in the specification, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds are valuable neurokinin (tachykinin) antagonists.Type: GrantFiled: August 2, 1997Date of Patent: November 16, 1999Assignee: Boehringer Ingelheim KGInventors: Horst Dollinger, Gerd Schnorrenberg, Hans Briem, Birgit Jung, Georg Speck
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Patent number: 5977359Abstract: The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from:A.sub.1) --O--CO--A.sub.2) --CH.sub.2 --O--CO--A.sub.3) --O--CH.sub.2 --CO--A.sub.4) --O--CH.sub.2 --CH.sub.2 --A.sub.5) --N(R.sub.1)--CO--A.sub.6) --N(R.sub.1)--CO--CO--A.sub.7) --N(R.sub.1)--CH.sub.2 --CH.sub.2 --A.sub.8) --O--CH.sub.2 --in which:R.sub.1 is a hydrogen or a (C.sub.1 -C.sub.4)-alkyl; andAm is a nitrogen-containing heterocycle.Type: GrantFiled: October 20, 1998Date of Patent: November 2, 1999Assignee: SanofiInventors: Xavier Emonds-Alt, Isabelle Grossriether, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
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Patent number: 5959104Abstract: Bleaching compositions are provided that comprise a nitrile containing compound that has the nitrile bonded to a quaternary nitrogen through a methylene unit (where one or both of the normal hydrogens can be substituted), and two of the quaternary nitrogen bonds are part of a saturated ring. This saturated ring contains from two to eight atoms in addition to the quaternary nitrogen. A source of active oxygen will react with the nitrile for bleaching applications. Particularly preferred nitrile containing compounds are N-alkyl morpholinium acetonitrile salts.Type: GrantFiled: April 13, 1998Date of Patent: September 28, 1999Assignee: The Clorox CompanyInventors: James W. Arbogast, James E. Deline, Lafayette D. Foland, Thomas W. Kaaret, Kevin A. Klotter, Michael J. Petrin, William L. Smith, Alfred G. Zielske
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Patent number: 5922872Abstract: Compositions comprising meta-benzylic compounds are prepared. The compositions are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compositions of the present invention are useful as research reagents.Type: GrantFiled: August 1, 1996Date of Patent: July 13, 1999Assignee: Isis Pharmaceuticals, Inc.Inventors: Phillip Dan Cook, Andrew M. Kawasaki
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Patent number: 5902883Abstract: The present invention relates to a process for the cyanobutylation of ammonia, an alkylamine or hydrazine with 3- and 4-pentenenitrile and mixtures thereof to form alkylaminonitriles.Type: GrantFiled: December 18, 1997Date of Patent: May 11, 1999Assignee: E. I. du Pont de Nemours and CompanyInventor: Frank Edward Herkes
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Patent number: 5892037Abstract: The invention relates to compounds obtainable by polymerization of esters or phenol ethers of the formula V ##STR1## and/or of the formula VI ##STR2## in which m and n are each 0 or 1, and A, E, R.sup.1 to R.sup.6 and X are as defined in claim 1, and up to 50 mol % of other, ethylenically unsaturated compounds. The homopolymers and copolymers according to the invention can advantageously be employed for the stabilization of organic polymers against the harmful effect of light, oxygen and/or heat.Type: GrantFiled: March 12, 1996Date of Patent: April 6, 1999Assignee: Ciba Specialty Chemicals CorporationInventor: Alfred Steinmann
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Patent number: 5861535Abstract: Tertiary aminoaryl compounds, such as N,N'dialkylaminoaryl compounds, are prepared using successive reductive steps without isolation therebetween, at high temperature and pressure. A nitroaryl compound is reduced using a ketone as both solvent and reactant in a reductive environment, and the resulting intermediate is further reacted with an aldehyde in the same reaction mixture without isolation to provide the second substituent on the amino group.Type: GrantFiled: September 23, 1997Date of Patent: January 19, 1999Assignee: Eastman Kodak CompanyInventor: Victor L. Mylroie
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Patent number: H2007Abstract: Compounds of the following structure are disclosed as effective insecticides: in which: A and B are independently lower alkyl; U is lower alkylidene, lower alkenylidene, or CH—Z, where Z is hydrogen, lower alkyl, lower cycloalkyl, or phenyl; R is phenyl or a dibenzocyclo(C5-8)alkyl, each optionally substituted, or where R3 and R4 are independently selected from phenyl, optionally substituted with, halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy, lower alkenyl, or phenyl; R1 is selected from a variety of substituents, including 3-R2, where R2 is where D, E, and G are hydrogen, hydroxy, halogen, cyano, hydroxy, lower alkyl, lower haloalkyl, lower alkoxy, nitro, lower haloalkylsuffonyloxy, lower alkylcarboxylato, lower alkylcarbonylamino, lower alkylcarbonyl, lower alkoxycarbonyl, arylcarbonylamino; D and E taken together may form the group —O(CH2)O—; J is hydrogen or lower alkyl; m is 2 or 3, n is 1, 2, or 3; and halogType: GrantFiled: January 9, 1997Date of Patent: December 4, 2001Assignee: FMC CorporationInventors: Ian R. Silverman, Syed F. Ali, Daniel H. Cohen, John W. Lyga, Kirk A. Simmons, Thomas G. Cullen