Silicon Containing Patents (Class 546/14)
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Patent number: 12262570Abstract: Provided are an organic electric element, a display panel and a display device having high efficiency or long life by including layers having excellent hole transport ability and carrier resistance.Type: GrantFiled: December 29, 2020Date of Patent: March 25, 2025Assignees: LG DISPLAY CO., LTD., SOLUS ADVANCED MATERIALS CO., LTD.Inventors: Seonkeun Yoo, Heejun Park, Soyoung Jang, Jiho Baek, Jeongdae Seo, Sunkap Kwon, Minchul Jun, Hyunchul Choi, Young Mo Kim, Jae Yi Sim
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Patent number: 12208075Abstract: The invention concerns antimicrobial compositions comprising free fatty acids emulsified with membrane lipids or hydrolysed derivatives thereof, and pharmaceutical formulations comprising same. The compositions can be used in the treatment of prophylaxis of microbial infections. They can also regulate the rate of blood clotting rendering them suitable for incorporation in catheter locking solutions and for use in wound care.Type: GrantFiled: November 29, 2021Date of Patent: January 28, 2025Assignee: WESTGATE BIOMEDICAL LTD.Inventor: Michael Anthony Folan
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Patent number: 12195479Abstract: A five-membered-fused six-membered compound, and a preparation method therefor and a pharmaceutical composition and the use thereof. The five- and six-membered compound is a compound as shown in formula I, II or III. The compound has an inhibitory effect on FLT3 and/or IRAK4.Type: GrantFiled: December 19, 2023Date of Patent: January 14, 2025Assignee: HANGZHOU POLYMED BIOPHARMACEUTICALS, INC.Inventors: Jason Shaoyun Xiang, Lei Wu, Rui Xu, Qiang Zhang, Gang Yang, Michael Xiang, Mixue Tong, Camille Xiang, Yuxin Liu, Suyue Wang, Rui Yang
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Patent number: 12162872Abstract: The present invention relates to a medicament for treating or preventing a disease related to orexin receptor, especially orexin type 2 receptor, comprising a new compound having a urea structure or a pharmaceutically acceptable salt thereof as an active ingredient. In more detail, the present invention relates to a medicament for treating or preventing narcolepsy, idiopathic hypersomnia, hypersomnia, sleep apnea syndrome, etc.Type: GrantFiled: November 26, 2020Date of Patent: December 10, 2024Assignee: Sumitomo Pharma Co., Ltd.Inventors: Eiji Ideue, Masafumi Komiya, Shoukou Lee, Shunichiro Uesugi, Yuta Funakoshi
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Patent number: 12043611Abstract: Complexes and devices, such as organic light emitting devices and full color displays, including a compound of the formula: wherein: M is Pd2+, Ir+, Rh+, or Au3+; each of V1, V2, V3, and V4 is coordinated to M and is independently N, C, P, B, or Si; each of L1, L2, L3, and L4 is independently a substituted or unsubstituted aryl, cycloalkyl, cycloalkenyl, heterocyclyl, heteroaryl, carbene, or N-heterocyclic carbene; and Z is O, S, NR, CR2, SiR2, BR, PR, ?where each R is independently substituted or unsubstituted C1-C4 alkyl or substituted or unsubstituted aryl.Type: GrantFiled: September 14, 2020Date of Patent: July 23, 2024Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Jian Li, Liang Huang, Tyler Fleetham
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Patent number: 11749422Abstract: Provided are methods for extending the life of in-service electrical cable having polymeric insulation, comprising injecting a dielectric enhancement fluid composition into the cable, wherein the composition comprises: (a) one or more organoalkoxysilane functional additives (voltage stabilizer-based, hindered amine light stabilizer (HALS)-based, and/or UV absorber-based); and (b) a catalyst suitable to catalyze hydrolysis and condensation of (a), the injected composition providing for rapid initial permeation of (a) into the insulation, and extended retention of subsequent condensation products of (a) in the insulation. Additionally provided are innovative silyl functional ferrocenes (e.g., containing a ferrocene moiety and a silyl function hydrolysable to silanol) having utility as functional voltage stabilizing additives in the methods.Type: GrantFiled: July 15, 2020Date of Patent: September 5, 2023Assignee: Novinium, LLCInventors: Glen J. Bertini, David C. Busby, Ramanathan Ravichandran, Miles J. Hutchings
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Patent number: 11749522Abstract: Provided are a composition for depositing a silicon-containing thin film containing a bis(aminosilyl)alkylamine compound and a method for manufacturing a silicon-containing thin film using the same, and more particularly, a composition for depositing a silicon-containing thin film, containing the bis(aminosilyl)alkylamine compound capable of being usefully used as a precursor of the silicon-containing thin film, and a method for manufacturing a silicon-containing thin film using the same.Type: GrantFiled: January 10, 2022Date of Patent: September 5, 2023Assignee: DNF CO., LTD.Inventors: Sung Gi Kim, Jeong Joo Park, Joong Jin Park, Se Jin Jang, Byeong-Il Yang, Sang-Do Lee, Sam Dong Lee, Sang Ick Lee, Myong Woon Kim
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Patent number: 11691993Abstract: A 1,1,1-tris(organoamino)disilane compound and a method of preparing the 1,1,1-tris(organoamino)disilane compound are disclosed. The method comprises aminating a 1,1,1-trihalodisilane with an aminating agent comprising an organoamine compound to give a reaction product comprising the 1,1,1-tris(organoamino)disilane compound, thereby preparing the 1,1,1-tris(organoamino)disilane compound. A film-forming composition is also disclosed. The film-forming composition comprises the 1,1,1-tris(organoamino)disilane compound. A film formed with the film-forming composition, and a method of forming the film, are also disclosed. The method of forming the film comprises subjecting the film-forming composition comprising the 1,1,1-tris(organoamino)disilane compound to a deposition condition in the presence of a substrate, thereby forming the film on the substrate.Type: GrantFiled: July 30, 2018Date of Patent: July 4, 2023Assignee: JIANGSU NATA OPTO-ELECTRONIC MATERIALS CO. LTD.Inventors: Byung K. Hwang, Xiaobing Zhou
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Patent number: 11672252Abstract: Disclosed herein are antifungal composites, devices, and methods to reduce or prevent a fungus from growing on the antifungal composite. The antifungal composite and devices thereof may include a biocompatible polymer and a Si3N4 powder loaded in at least a portion of the biocompatible polymer. The polymer may be a thermoplastic polymer such as a poly(methyl methacrylate) (PMMA) resin and the Si3N4 powder may be present in a concentration of about 1 vol. % to about 30 vol. % in the thermoplastic polymer.Type: GrantFiled: January 22, 2021Date of Patent: June 13, 2023Assignee: SINTX Technologies, Inc.Inventors: Bhajanjit Singh Bal, Bryan J. McEntire, Ryan M. Bock
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Patent number: 11649547Abstract: A method for depositing a film comprising silicon and oxygen onto a substrate includes (a) providing a substrate in a reactor; (b) introducing into the reactor at least one silicon precursor compound selected from the group consisting of Formulae A, B, and C as described herein, (c) purging the reactor with a purge gas; (d) introducing at least one of an oxygen-containing source and a nitrogen-containing source into the reactor; and (e) purging the reactor with the purge gas, wherein the steps b through e are repeated until a desired thickness of resulting silicon-containing film is deposited; and (f) treating the resulting silicon-containing film with R3xSi(NR1R2)4-x wherein R1-3 are the same as aforementioned, preferably methyl or ethyl; and x=1, 2, or 3; and wherein the method is conducted at one or more temperatures ranging from about 20° C. to 300° C.Type: GrantFiled: February 4, 2020Date of Patent: May 16, 2023Assignee: Versum Materials US, LLCInventors: Meiliang Wang, Xinjian Lei, Haripin Chandra, Matthew R. MacDonald
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Patent number: 11562900Abstract: Methods for depositing silicon oxycarbide (SiOC) thin films on a substrate in a reaction space are provided. The methods can include at least one plasma enhanced atomic layer deposition (PEALD) cycle including alternately and sequentially contacting the substrate with a silicon precursor that does not comprise nitrogen and a second reactant that does not include oxygen. In some embodiments the methods allow for the deposition of SiOC films having improved acid-based wet etch resistance.Type: GrantFiled: March 6, 2020Date of Patent: January 24, 2023Assignee: ASM IP HOLDING B.V.Inventors: Toshiya Suzuki, Viljami J. Pore, Hannu Huotari
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Patent number: 11505527Abstract: The present disclosure provides tetrahydroquinoline derivatives of Formula (I) wherein X1 and X2 each, independently, are oxygen or sulphur; R1 is a lower alkoxy, or an optionally substituted aryl group; R2 is selected from a group consisting of hydrogen, lower alkyl, haloalkyl, or an amino group; R3 and R4 each, independently, are hydrogen, or lower alkyl groups; and R5 and R6 are optionally substituted aryl groups. The present disclosure also provides a method for making the compound of Formula (I).Type: GrantFiled: May 27, 2022Date of Patent: November 22, 2022Assignee: KING ABDULAZIZ UNIVERSITYInventors: Mohamed Mostafa, Tamer Said Sayed Saleh, Nesreen Said Ismael Ahmed, Khadijah Saad Said Alghamdi, Dina Abed Bakhotmah
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Patent number: 11482684Abstract: Novel phosphorescent metal complexes containing 2-phenylisoquinoline ligands with at least two substituents on the isoquinoline ring are provided. The disclosed compounds have low sublimation temperatures that allow for ease of purification and fabrication into a variety of OLED devices.Type: GrantFiled: September 6, 2019Date of Patent: October 25, 2022Assignee: UNIVERSAL DISPLAY CORPORATIONInventors: Bin Ma, Alan Deangelis, Chuanjun Xia
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Patent number: 11467326Abstract: A color filtering film, a color filter substrate and a display device are disclosed. The color filtering film includes: a color filtering layer and a quantum dot layer laminated on the color filtering layer. The color filtering layer includes a plurality of groups of color filtering units, each group of color filtering units includes a first color filtering unit and a fourth color filtering unit, any first color filtering unit being spaced apart from the third color filtering unit.Type: GrantFiled: July 13, 2018Date of Patent: October 11, 2022Assignees: Hefei BOE Optoelectronics Technology Co., Ltd., Beijing BOE Technology Development Co., Ltd.Inventor: Yuanhui Guo
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Patent number: 11434197Abstract: The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear or branched alkyl group and R4 is hydrogen or an amine protecting group.Type: GrantFiled: June 7, 2019Date of Patent: September 6, 2022Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.Inventors: Stefano Fogal, Paolo Stabile, Pierluigi Padovan, Matteo De Poli, Angelo Restelli
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Patent number: 11198701Abstract: Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as “biaryl compound”), biaryl complexes, methods of making biaryl compounds, methods of making single enantiomers of these biaryl compounds, methods of use (e.g., catalysis), and the like.Type: GrantFiled: February 17, 2020Date of Patent: December 14, 2021Assignee: University of Florida Research Foundation, Inc.Inventors: Aaron Aponick, Flavio S. P. Cardoso
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Patent number: 11098068Abstract: A method of producing a halosiloxane, the method comprising: i) combining water, a halosilane, and a first solvent to form a reaction mixture, ii) partially hydrolyzing and condensing the halosilane to form a reaction product mixture comprising the halosiloxane, the solvent, unreacted halosilane, and hydrogen halide, iii) adding a second solvent, where the second solvent has a boiling point the boiling point of the halosiloxane, to the reaction mixture in i) or to the reaction product mixture in ii), and iv) recovering the halosiloxane from the reaction product mixture.Type: GrantFiled: May 24, 2018Date of Patent: August 24, 2021Assignee: Dow Silicones CorporationInventors: Noel Mower Chang, Barry Ketola, Andrew Millward, Xiaobing Zhou
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Patent number: 11028107Abstract: The present invention is directed to compositions for silylating organic substrates containing C—H or O—H bonds, especially heteroaromatic substrates. The compositions are derived from the preconditioning of mixtures of hydrosilanes or organodisilanes with bases, including metal hydroxide and metal alkoxide bases. In some embodiments, the preconditioning results in the formation of reactive silicon hydride species.Type: GrantFiled: February 22, 2017Date of Patent: June 8, 2021Assignee: California Institute of TechnologyInventors: Anton Toutov, Wenbo Liu, David P. Schuman, Brian M. Stoltz, Robert H. Grubbs
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Patent number: 10975106Abstract: To provide an organic silicon compound having an average structural formula (1). (Z represents a 2 to 20-valent group containing an organosiloxane structure, each R1 independently represents an alkyl group or an aryl group, each R2 independently represents an alkyl group or an aryl group, each R3 independently represents a hydrogen atom, an alkyl group, an alkoxy group, or an O. (oxy radical), each R4 independently represents a hydrogen atom or an alkyl group, each A1 independently represents a single bond or an alkylene group free of a hetero atom, each A2 independently represents a single bond or a divalent linking group containing a hetero atom, m is a number of 1 to 3, p is a number of 1 to 10, q is a number of 1 to 10, and p+q represents a number satisfying from 2 to 20 corresponding to the valency number of Z.Type: GrantFiled: February 6, 2020Date of Patent: April 13, 2021Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Tetsuro Yamada, Munenao Hirokami
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Patent number: 10618922Abstract: Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as “biaryl compound”), biaryl complexes, methods of making biaryl compounds, methods of making single enantiomers of these biaryl compounds, methods of use (e.g., catalysis), and the like.Type: GrantFiled: March 21, 2018Date of Patent: April 14, 2020Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: Aaron Aponick, Flavio S. P. Cardoso
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Patent number: 10412715Abstract: A method and a user equipment (UE) for transmitting a demodulation reference signal for a physical uplink shared channel (PUSCH) in a wireless communication system are discussed. The method according to an embodiment includes configuring a virtual cell identity (ID) which is different from a physical cell ID; generating a base sequence by using the virtual cell ID; obtaining a cyclic shift hopping pattern for each slot by using a UE-specific parameter; generating the demodulation reference signal for the PUSCH by using the base sequence and the cyclic shift hopping pattern for each slot; and transmitting the demodulation reference signal for the PUSCH to an eNodeB (eNB).Type: GrantFiled: October 5, 2016Date of Patent: September 10, 2019Assignee: LG ELECTRONICS INC.Inventors: Min Seok Noh, Jae Hoon Chung, Hyun Soo Ko
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Patent number: 9994571Abstract: The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R1-R9, Y, Z are defined as set forth in the specification. The invention is also directed to use of compounds of Formula (I) and the pharmaceutically acceptable salts and solvates thereof to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.Type: GrantFiled: December 23, 2014Date of Patent: June 12, 2018Assignee: Purdue Pharma L.P.Inventor: Laykea Tafesse
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Patent number: 9994599Abstract: Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as “biaryl compound”), biaryl complexes, methods of making biaryl compounds, methods of making single enantiomers of these biaryl compounds, methods of use (e.g., catalysis) and the like.Type: GrantFiled: September 12, 2014Date of Patent: June 12, 2018Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: Aaron Aponick, Flavio S. P. Cardoso
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Patent number: 9969711Abstract: A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.Type: GrantFiled: October 14, 2016Date of Patent: May 15, 2018Assignee: OPKO Health, Inc.Inventors: Anandan Palani, Xianhai Huang, Dong Xiao, Sunil Paliwal, Hon-Chung Tsui, Michelle Laci Wrobleski, Ashwin U. Rao, Cheng Wang, Sapna S. Shah, Neng-Yang Shih
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Reactions of aromatic substrates with base-activated hydrosilanes-silylations and reductive cleavage
Patent number: 9908840Abstract: The present invention describes chemical systems and methods for reducing C—O, C—N, and C—S bonds, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said system optionally comprising at least one molecular hydrogen donor compound, molecular hydrogen, or both.Type: GrantFiled: October 2, 2013Date of Patent: March 6, 2018Assignee: California Institute of TechnologyInventors: Robert H. Grubbs, Alexey Fedorov, Anton Toutov, Nicholas A. Swisher -
Patent number: 9688693Abstract: A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.Type: GrantFiled: July 25, 2014Date of Patent: June 27, 2017Assignee: OPKO Health, Inc.Inventors: Sunil Paliwal, Gregory A. Reichard, Cheng Wang, Dong Xiao, Hon-Chung Tsui, Neng-Yang Shih, Juan D. Arredondo, Michelle Laci Wrobleski, Anandan Palani
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Patent number: 9681664Abstract: The disclosure relates to macrocyclic picolinamides of Formula (I) and to the use of these compounds as fungicides.Type: GrantFiled: December 27, 2013Date of Patent: June 20, 2017Assignee: Dow AgroSciences LLCInventors: Rebecca Lalonde, Kevin G. Meyer, Fangzheng Li, Jeremy Wilmot, Karla Bravo-Altamirano, Chenglin Yao, Iain O'Callaghan, Jessica Herrick, Kyle DeKorver, Yu Lu
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Patent number: 9589896Abstract: An electronic circuit structure comprising a substrate, a dielectric layer on top of the substrate and comprising a cavity having side-walls, a manganese or manganese nitride layer covering the side-walls, and a self-assembled monolayer, comprising an organic compound of formula Z-L-A, covering the manganese or manganese nitride layer, wherein Z is selected from the list consisting of a primary amino group, a carboxylic acid group, a thiol group, a selenol group and a heterocyclic group having an unsubstituted tertiary amine in the cycle, wherein L is an organic linker comprising from 1 to 12 carbon atoms and from 0 to 3 heteroatoms, and wherein A is a group attaching the linker to the manganese or manganese nitride layer.Type: GrantFiled: March 10, 2016Date of Patent: March 7, 2017Assignee: IMEC VZWInventor: Silvia Armini
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Patent number: 9549556Abstract: The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides.Type: GrantFiled: December 19, 2014Date of Patent: January 24, 2017Assignee: Dow AgroSciences LLCInventors: Kyle DeKorver, Johnathan E. DeLorbe, Kevin G. Meyer, Chenglin Yao, Ronald J. Heemstra, William H. Dent, III
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Patent number: 9469629Abstract: A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.Type: GrantFiled: June 13, 2014Date of Patent: October 18, 2016Assignee: OPKO Health, Inc.Inventors: Anandan Palani, Xianhai Huang, Dong Xiao, Sunil Paliwal, Hon-Chung Tsui, Michelle Laci Wrobleski, Ashwin U. Rao, Cheng Wang, Sapna S. Shah, Neng-Yang Shih
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Patent number: 9381506Abstract: Disclosed herein are cobalt terpyridine complexes containing a single ligand coordinated to the cobalt, and their use as hydrosilylation and/or dehydrogenative silylation and crosslinking catalysts. The cobalt complexes also exhibit adequate air stability for handling and manipulation.Type: GrantFiled: November 19, 2014Date of Patent: July 5, 2016Assignees: Momentive Performance Materials Inc., Princeton UniversityInventors: Tianning Diao, Paul J. Chirik, Aroop Kumar Roy, Kenrick Lewis, Keith J. Weller, Johannes G. P. Delis, Renyuan Yu
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Patent number: 9318716Abstract: Disclosed is a composition comprising perylenediimide bridged dimethylethoxysilane. Disclosed also is an electronically active nanostructure comprising perylenediimide bridged dimethylethoxysilane. Disclosed also is a process for fabricating a photovoltaic device comprising depositing an electronically active nanostructure, the nanostructure made by hydrolysis and condensation of perylenediimide bridged dimethylethoxysilane, onto a substrate.Type: GrantFiled: September 20, 2013Date of Patent: April 19, 2016Assignee: Western Kentucky University Research FoundationInventor: Hemali Rathnayake
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Publication number: 20150147893Abstract: Classes of liquid aminosilanes have been found which allow for the production of silicon carbo-nitride films of the general formula SixCyNz. These aminosilanes, in contrast, to some of the precursors employed heretofore, are liquid at room temperature and pressure allowing for convenient handling. In addition, the invention relates to a process for producing such films. The classes of compounds are generally represented by the formulas: and mixtures thereof, wherein R and R1 in the formulas represent aliphatic groups typically having from 2 to about 10 carbon atoms, e.g., alkyl, cycloalkyl with R and R1 in formula A also being combinable into a cyclic group, and R2 representing a single bond, (CH2)n, a ring, or SiH2.Type: ApplicationFiled: December 16, 2014Publication date: May 28, 2015Applicant: AIR PRODUCTS AND CHEMICALS, INC.Inventors: Manchao Xiao, Arthur Kenneth Hochberg
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Publication number: 20150144937Abstract: Provided are a compound represented by the following Chemical Formula 1 for an organic optoelectronic device, an organic light emitting diode including the same, and a display device including the organic light emitting diode. The structure of Chemical Formula 1 is described in the specification. The compound for the organic photoelectric device provides an organic light emitting diode having excellent life-span characteristics due to excellent electrochemical and thermal stability and high luminous efficiency at a low driving voltage.Type: ApplicationFiled: February 3, 2015Publication date: May 28, 2015Inventors: Moo-Jin PARK, Eun-Sun YU, Mi-Young CHAE, Byung-Ku KIM, Hyo-Ju SEO, Jae-Deuk YANG
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Publication number: 20150136700Abstract: The present invention provides a chromatographic stationary phase material various different types of chromatography. One example chromatographic stationary phase is represented by Formula 1 [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition. W can be absent and/or can include hydrogen and/or can include hydroxyl on the surface of X. Q can be bound directly to X and can include a first hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. T can be bound directly to X and can include a second hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. Additionally, Q and T can essentially eliminate chromatographic interaction between the analyte, and X and W, thereby minimizing retention variation over time (drift or change) under chromatographic conditions utilizing low water concentrations.Type: ApplicationFiled: May 15, 2013Publication date: May 21, 2015Applicant: Waters Technologies CorporationInventors: Darryl W. Brousmiche, Kevin D. Wyndham, Jacob N. Fairchild, Pamela C. Iraneta, Jason F. Hill
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Publication number: 20150133400Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.Type: ApplicationFiled: September 15, 2014Publication date: May 14, 2015Inventors: Jiazhong Zhang, John Buell, Katrina Chan, Prabha N. Ibrahim, Jack Lin, Phuongly Pham, Songyuan Shi, Wayne Spevak, Guoxian Wu, Jeffrey Wu
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Publication number: 20150133294Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05?(b/c)?100, and a?0.Type: ApplicationFiled: May 15, 2013Publication date: May 14, 2015Applicant: Waters Technologies CorporationInventors: Kevin D. Wyndham, Michael F. Morris, Darryl W. Brousmiche, Jason F. Hill, Jacob N. Fairchild
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Publication number: 20150133301Abstract: 3-alkoxy, thioalkyl and amino-4-amino-6-(substituted)picolinic acids having a halogen, alkyl or mono-, di-tri- and tetra-substituted aryl substituents in the 6-position, and their acid derivatives, are herbicides demonstrating a broad spectrum of weed control.Type: ApplicationFiled: April 29, 2014Publication date: May 14, 2015Applicant: DOW AGROSCIENCES LLCInventors: Jeffrey B. Epp, Christian T. Lowe, James M. Renga, Paul R. Schmitzer, Joseph D. Eckelbarger, Katherine A. Guenthenspberger, Thomas L. Siddall, Carla N. Yerkes, Lindsey G. Fischer, Natalie C. Giampietro, Jeremy Kister, Joshua Roth
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Publication number: 20150133603Abstract: The invention relates to low-viscosity polymers containing silane groups, the polymers curing rapidly under the effect of moisture to form an elastic material with good heat resistance and being in particular suitable for elastic adhesives and sealants. The polymers containing silane groups are based on special hydoxysilanes which carry a secondary OH group. They are in particular obtained by reacting epoxysilanes with secondary amines.Type: ApplicationFiled: May 22, 2013Publication date: May 14, 2015Inventors: Andreas Kramer, Urs Burckhardt
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Patent number: 9028880Abstract: The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein.Type: GrantFiled: November 30, 2011Date of Patent: May 12, 2015Assignee: The Board of Trustees of the University of IllinoisInventors: Jianjun Cheng, Li Tang
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Patent number: 9029536Abstract: The present invention provides a compound which has the effect of PDE 10A inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on.Type: GrantFiled: August 3, 2011Date of Patent: May 12, 2015Assignee: Takeda Pharmaceutical Company LimitedInventors: Joseph Raker, Takahiko Taniguchi, Masato Yoshikawa, Tomoaki Hasui, Jun Kunitomo
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Patent number: 9029352Abstract: The present invention is directed to a process for the preparation of heterocyclic derivatives of formula I wherein J, X, Z, and R2 are as defined herein. Such compounds are useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.Type: GrantFiled: August 5, 2013Date of Patent: May 12, 2015Assignee: Janssen Pharmaceutica NVInventors: Krzysztof Kolodziejczyk, Alfred Elisabeth Stappers, Christopher A. Teleha, Koen Johan Herman Weerts
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Publication number: 20150099887Abstract: The disclosure generally relates to a process for the preparation of compounds of formula I, including synthetic intermediates which are useful in the process.Type: ApplicationFiled: December 12, 2014Publication date: April 9, 2015Inventors: David K. Leahy, Yu Fan, Collin Chan, Lopa V. Desai, Sunil S. Patel, Masano Sugiyama
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Publication number: 20150099414Abstract: An organosilicon compound having a hydrolyzable silyl group and pyridine ring in the molecule is provided. A composition comprising a polymer having an isocyanate, epoxy or acid anhydride in admixture with the organosilicon compound is shelf stable.Type: ApplicationFiled: September 22, 2014Publication date: April 9, 2015Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Munenao HIROKAMI
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Patent number: 8999734Abstract: Disclosed herein are mono-functional silylating compounds that may exhibit enhanced silylating capabilities. Also disclosed are method of synthesizing and using these compounds. Finally methods to determine effective silylation are also disclosed.Type: GrantFiled: March 10, 2010Date of Patent: April 7, 2015Assignee: American Air Liquide, Inc.Inventors: James J. F. McAndrew, Curtis Anderson, Christian Dussarrat
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Patent number: 8999955Abstract: The invention relates to kinase inhibitors of the formula (I) in which —R1 to R4?H; ether or polyether, amino; NO2; NH-carbamate; NH—CO—R, with R such as defined above; N3 and derivatives thereof of the 1,2,3-triazole type; —R5=—OH; halogen; —OR with R such as defined above; OH-carbamate; OH-carbonate; NH2, NH-carbamate; NH—CO—R, with R such as defined above; N3 and derivatives thereof of the 1,2,3-triazole type; N(R9,R10); —R5??H or a C1-C12 alkyl, —R6?H; R; (R or R?)3—Si, with R such as defined above; optionally substituted aryl, heteroaryl; halogen (iodine); alkynyl; —R7 and R8?H, C1-C12 alkyl; —R9 and R10?H, R (or R?) such as defined above. These compounds can be used as kinase inhibitors in particular for treating cancer.Type: GrantFiled: January 19, 2009Date of Patent: April 7, 2015Assignee: Centre National de la Recherche ScientifiqueInventors: Philippe Olivier Belmont, Laurent Meijer, Philip Cohen, Amaury Patin, Johann Bosson, Peter Gregory Goekjian
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Patent number: 9000167Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate; wherein said system is substantially free of a transition-metal compound.Type: GrantFiled: October 2, 2013Date of Patent: April 7, 2015Assignee: California Institute of TechnologyInventors: Robert H. Grubbs, Alexey Fedorov, Anton Toutov, Kerry Betz
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Patent number: 8999957Abstract: The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.Type: GrantFiled: June 22, 2011Date of Patent: April 7, 2015Assignee: Merck Sharp & Dohme Corp.Inventors: Yongqi Deng, Liang Zhu, Gerald W. Shipps, Jr., Sie-Mun Lo, Binyuan Sun, Xiaohua Huang, Corey Bienstock, Alan B. Cooper, Xiaolei Gao, Xin Yao, Hugh Y. Zhu, Joseph M. Kelly, Sobhana Babu Boga, Abdul-Basit Alhassan, Jayaram R. Tagat, Umar Faruk Mansoor, Kevin J. Wilson, Brendan M. O'Boyle, Matthew Hersh Daniels, Adam Schell, Phieng Siliphaivanh, Christian Fischer
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Publication number: 20150094470Abstract: Compounds and method of preparation of Si—X and Ge—X compounds (X?N, P, As and Sb) via dehydrogenative coupling between the corresponding unsubstituted silanes and amines (including ammonia) or phosphines catalyzed by metallic catalysts is described. This new approach is based on the catalytic dehydrogenative coupling of a Si—H and a X—H moiety to form a Si—X containing compound and hydrogen gas (X?N, P, As and Sb). The process can be catalyzed by transition metal heterogenous catalysts such as Ru(0) on carbon, Pd(0) on MgO) as well as transition metal organometallic complexes that act as homogeneous catalysts. The —Si—X products produced by dehydrogenative coupling are inherently halogen free. Said compounds can be useful for the deposition of thin films by chemical vapor deposition or atomic layer deposition of Si-containing films.Type: ApplicationFiled: September 19, 2014Publication date: April 2, 2015Inventors: Antonio Sanchez, Gennadily Itov, Peng Zhang, Matthew Damien Stephens
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Patent number: 8993072Abstract: Described herein are precursors and methods of forming films. In one aspect, there is provided a precursor having Formula I: XmR1nHpSi(NR2R3)4-m-n-p??I wherein X is selected from Cl, Br, I; R1 is selected from linear or branched C1-C10 alkyl group, a C2-C12 alkenyl group, a C2-C12 alkynyl group, a C4-C10 cyclic alkyl, and a C6-C10 aryl group; R2 is selected from a linear or branched C1-C10 alkyl, a C3-C12 alkenyl group, a C3-C12 alkynyl group, a C4-C10 cyclic alkyl group, and a C6-C10 aryl group; R3 is selected from a branched C3-C10 alkyl group, a C3-C12 alkenyl group, a C3-C12 alkynyl group, a C4-C10 cyclic alkyl group, and a C6-C10 aryl group; m is 1 or 2; n is 0, 1, or 2; p is 0, 1 or 2; and m+n+p is less than 4, wherein R2 and R3 are linked or not linked to form a ring.Type: GrantFiled: September 18, 2012Date of Patent: March 31, 2015Assignee: Air Products and Chemicals, Inc.Inventors: Manchao Xiao, Xinjian Lei, Mark Leonard O'Neill, Bing Han, Ronald Martin Pearlstein, Haripin Chandra, Heather Regina Bowen, Agnes Derecskei-Kovacs