Silicon Containing Patents (Class 546/14)
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Publication number: 20110311601Abstract: A medical device having a silane surface comprising an antimicrobial peptide exhibiting a complex tertiary structure, wherein the antimicrobial peptide is attached to the silane surface via reversible interaction.Type: ApplicationFiled: June 22, 2011Publication date: December 22, 2011Inventors: Michael Kleine, Martin Christian Weigel, Karsten Hofmann-Peiker
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Publication number: 20110301122Abstract: The present application relates to novel substituted aryl compounds, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.Type: ApplicationFiled: October 31, 2009Publication date: December 8, 2011Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: Michael Härter, Hartmut Beck, Peter Ellinghaus, Kerstin Berhörster, Susanne Greschat, Karl-Heinz Thierauch, Frank Süssmeier
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Publication number: 20110293852Abstract: This invention relates to organometallic precursor compounds represented by the formula (H)mM(R)n wherein M is a metal or metalloid, R is the same or different and is a substituted or unsubstituted, saturated or unsaturated, heterocyclic radical containing at least one nitrogen atom, m is from 0 to a value less than the oxidation state of M, n is from 1 to a value equal to the oxidation state of M, and m+n is a value equal to the oxidation state of M, a process for producing the organometallic precursor compounds, and a method for producing a film or coating from the organometallic precursor compounds.Type: ApplicationFiled: December 19, 2007Publication date: December 1, 2011Inventor: Scott Houston Meiere
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Patent number: 8067595Abstract: In order to efficiently supply CPT, which is a starting compound of irinotecan hydrochloride and a variety of camptothecin derivatives, by a practical total synthesis, the invention provides a means of efficiently preparing a tricyclic ketone that corresponds to a CDE ring moiety of a camptothecin (CPT) skeleton.Type: GrantFiled: June 8, 2006Date of Patent: November 29, 2011Assignee: Kabushiki Kaisha Yakult HonshaInventors: Hiroyuki Nishiyama, Seigo Sawada
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Publication number: 20110287408Abstract: A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.Type: ApplicationFiled: May 3, 2011Publication date: November 24, 2011Inventors: Zoran Popovic, Manuel Matthias Tsotsalas, Michael Busby, Luisa De Cola, Gion Calzaferri, Hans-Peter Josel
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Publication number: 20110288051Abstract: Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I: or stereoisomers or pharmaceutically acceptable salts thereof, wherein G, Q, X, Y, R3, R3a, and R3b are defined herein.Type: ApplicationFiled: August 3, 2011Publication date: November 24, 2011Inventors: Jun Li, Jeffrey A. Robl, James J. Li, Lawrence J. Kennedy, Haixia Wang, Jie Jack Li, Chenkou Wei, Michael Galella
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Publication number: 20110287369Abstract: There is provided a resist underlayer film forming composition for lithography for forming a resist underlayer film capable of being used as a hardmask. A resist underlayer film forming composition for lithography comprising a silane compound containing an anion group, wherein the silane compound containing an anion group is a hydrolyzable organosilane in which an organic group containing an anion group is bonded to a silicon atom and the anion group forms a salt structure, a hydrolysis product thereof, or a hydrolysis-condensation product thereof. The anion group may be a carboxylic acid anion, a phenolate anion, a sulfonic acid anion, or a phosphonic acid anion. The hydrolyzable organosilane may be a compound of Formula (1): R1aR2bSi(R3)4?(a+b) (1).Type: ApplicationFiled: December 16, 2009Publication date: November 24, 2011Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Wataru Shibayama, Makoto Nakajima, Yuta Kanno
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Publication number: 20110281388Abstract: The present invention relates to modified quantum dots (QDs) and methods for using and producing the same. Some aspects of the invention provide cross-linked quantum dots and methods for producing and using the same.Type: ApplicationFiled: November 13, 2008Publication date: November 17, 2011Applicant: HCF PARTNERS, LPInventors: Neil Gough, Arrelaine A. Dameron, Ethan Tsai
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Publication number: 20110282060Abstract: The invention described herein provides for novel nitric oxide-releasing polymers that comprise at least two adjacent units derived from acrylonitrile monomer units and containing at least one carbon-bound diazeniumdiolate. The diazeniumdiolated acrylonitrile-derived polymers can be used in medical devices therapeutically. Accordingly, the invention also provides a method of treating a biological disorder and a method of promoting angiogenesis that includes administering a medical device comprising a nitric oxide-releasing polymer comprising at least two adjacent units of acrylonitrile before exposure to nitric oxide and at least one nitric oxide releasing N2O2? group, wherein the N2O2? group is attached directly to the polyacrylonitrile backbone, to a specific location on or within the mammal in an amount effective to treat the biological disorder or promote angiogenesis.Type: ApplicationFiled: May 19, 2011Publication date: November 17, 2011Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Joseph A. Hrabie, Frank DeRosa, Larry K. Keefer
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Publication number: 20110275595Abstract: The present invention relates to compounds defined by formula I wherein the groups R1, Y1 to Y4, V, W, and X are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 ?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.Type: ApplicationFiled: October 22, 2009Publication date: November 10, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Matthias Eckhardt, Bradford S. Hamilton, Frank Himmelsbach
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Publication number: 20110275792Abstract: A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.Type: ApplicationFiled: July 15, 2011Publication date: November 10, 2011Inventor: Thomas Piccariello
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Publication number: 20110269962Abstract: Process for the preparation of ?-ketoester synthetic intermediates useful in the preparation of statins, in particular Pitavastatin.Type: ApplicationFiled: April 22, 2011Publication date: November 3, 2011Applicant: DIPHARMA FRANCIS S.R.L.Inventors: Maurizio TADDEI, Evita BALDUCCI, Emanuele ATTOLINO, Simone MANTEGAZZA, Gianmaria DELL'ANNA
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Publication number: 20110269712Abstract: This invention is directed to compounds of Formula (1) including all geometric and stereoisomers, N oxides, and agriculturally suitable salts thereof, agricultural compositions containing them and their use as fungicides, (1) provided that the compound of Formula 1 is other than 2-[1-[(2-chlorophenyl)acetyl]-4-piperidinyl]-N-methyl-N-[(1R)-1-phenylethyl]-4-thiazolecarboxamide and R1 is other than 4-fluorophenyl; wherein R1, R2, A, G, Q, W1, W2, X and n are otherwise as defined in the disclosure, Also disclosed are compositions containing the a compound having a formula corresponding to Formula (1) where the provisos are both omitted; and methods for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound having a formula corresponding to Formula (1) where the provisos are both omitted.Type: ApplicationFiled: July 26, 2006Publication date: November 3, 2011Inventors: John Joseph Bisaha, Patrick Ryan Kovacs, Renne M. Lett, Jeffrey Keith Long, Robert James Pasteris, Boris Abramovich Klyashchitsky, Bruce Lawrence Finkelstein, Brenton Todd Smith
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Publication number: 20110263529Abstract: In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.Type: ApplicationFiled: November 5, 2009Publication date: October 27, 2011Inventors: Ruo Xu, John W. Clader
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Patent number: 8026364Abstract: A compound having the general structure shown in Formula I: or pharmaceutically acceptable salt and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.Type: GrantFiled: March 30, 2010Date of Patent: September 27, 2011Assignee: OPKO Health, Inc.Inventors: Sapna S. Shah, Anandan Palani, Xianhai Huang, Dong Xiao, Sunil Paliwal, Hon-Chung Tsui, Michelle Laci Wrobleski, Ashwin U. Rao, Cheng Wang, Neng-Yang Shih
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Publication number: 20110223134Abstract: The present invention relates to novel Fused Tricyclic Silyl Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, D, M1, X1 and X2 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Silyl Compound, and methods of using the Fused Tricyclic Silyl Compounds for treating or preventing HCV infection in a patient.Type: ApplicationFiled: March 4, 2011Publication date: September 15, 2011Inventors: Anilkumar Gopinadhan Nair, Kerry M. Keertikar, Seong Heon Kim, Joseph A. Kozlowski, Stuart Rosenblum, Oleg B. Selyutin, Michael Wong, Wensheng Yu, Qingbei Zeng
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Publication number: 20110220881Abstract: The invention provides a light emitting layer host compound and an electron-blocking compound that have high excited triplet levels, and can completely confine the triplet excitons of phosphorescent material, for use as the material of a high-efficient organic electroluminescent device. The invention also provides a high-efficient, high-luminance organic electroluminescent device with the use of the compounds. The compound of the general formula (1) below has a triphenylsilyl group and a triarylamine structure, and the organic electroluminescent device includes a pair of electrodes and at least one organic layer interposed between the pair of electrodes, wherein the compound of the general formula (1) having a triphenylsilyl group and a triarylamine structure is used as constituent material of the at least one organic layer.Type: ApplicationFiled: November 9, 2009Publication date: September 15, 2011Applicants: HODOGAYA CHEMICAL CO., LTD., SHINSHU UNIVERSITYInventors: Norimasa Yokoyama, Shuichi Hayashi, Yoshio Taniguchi, Musubu Ichikawa, Shinichi Matsuki
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Patent number: 8013157Abstract: Syntheses of unsaturated piperidines from piperidones through a silyl piperidine reagent via the Shapiro reaction and palladium-catalyzed cross-coupling reactions with organo halides.Type: GrantFiled: December 19, 2007Date of Patent: September 6, 2011Assignee: Janssen Pharmaceutica NVInventors: Neelakandha S. Mani, Christie Morrill
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Publication number: 20110207698Abstract: The present application relates to novel heteroaryl-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.Type: ApplicationFiled: February 26, 2009Publication date: August 25, 2011Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: Daniel Meibom, Alexandros Vakalopoulos, Barbara Albrecht-Küpper, Katja Zimmermann, Peter Nell, Frank Süßmeier
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Publication number: 20110206607Abstract: Disclosed herein are compounds of Formula (I), or a pharmaceutically acceptable salt, ester, amide, thereof; and methods of modulating the activity of a cannabinoid CB2 receptor comprising contacting a compound of Formula I with the cannabinoid CB2 receptor. Also disclosed are methods of imaging of a tissue by positron emission tomography, the method comprising administering to the subject a compound of Formula I, wherein the compound comprises a radioisotope. Also disclosed are methods of measuring the relative concentration of cannabinoid CB2 receptors in tissue of a subject, by using a compound of Formula I which comprises a radioisotope. In addition, method of diagnosing a disorder in a subject are disclosed.Type: ApplicationFiled: May 9, 2008Publication date: August 25, 2011Inventors: Roger Olsson, Ethan Burstein, Anne Eeg Knapp, Jorgen Eskildsen, Joel Castillo, James Nairne, Veronique Morisson-Iveson, Edward Robins, Alex Gibson
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Publication number: 20110207699Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.Type: ApplicationFiled: December 9, 2010Publication date: August 25, 2011Applicant: ABBOTT LABAORATORIESInventors: David A. DeGoey, Warren M. Kati, Charles W. Hutchins, Pamela L. Donner, Allan C. Krueger, John T. Randolph, Christopher E. Motter, Lissa T. Nelson, Sachin V. Patel, Mark A. Matulenko, Ryan G. Keddy, Tammie K. Jinkerson, Todd N. Soltwedel, Douglas K. Hutchinson, Charles A. Flentge, Rolf Wagner, Clarence J. Maring, Michael D. Tufano, David A. Betebenner, Todd W. Rockway, Dachun Liu, John K. Pratt, Michael J. Lavin, Kathy Sarris, Kevin R. Woller, Seble H. Wagaw, Jean C. Califano, Wenke Li, Daniel D. Caspi, Mary E. Bellizzi, William A. Carroll
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Publication number: 20110207700Abstract: The present invention relates to the compound represented by formula (I): (wherein, all the symbols have the same meaning as that of the specification), a salt thereof, a solvate thereof or a prodrug thereof. Since the compound of the present invention has an anti stress action, it is useful for preventive and/or therapeutic agent for a disease caused by stress, especially a digestive system disease caused by stress and is superior to oral absorption.Type: ApplicationFiled: April 29, 2011Publication date: August 25, 2011Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Kazuyuki OHMOTO, Masashi KATO, Yoshifumi KAGAMIISHI, Junichiro MANAKO
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Publication number: 20110195929Abstract: Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described.Type: ApplicationFiled: August 4, 2009Publication date: August 11, 2011Applicant: SUMMIT CORPORATION PLCInventors: Olivier De Moor, Graeme Horne, Penny Jane Middleton, Frank Schroer, Stephen Paul Wren, Maria Ines Passos Eleuterio, Renate Van Well, Colin Richard Dorgan, Francis Xavier Wilson, Robert Nash, Richard Storer, Graham Michael Wynne, Alan Geoffrey Roach, Akane Kawamura, Jonathon Mark Tinsley
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Publication number: 20110193064Abstract: An organic EL device includes an emitting layer provided between an anode and a cathode. The emitting layer contains a diaminopyrene derivative represented by the following formula (1) as an emitting material for the organic EL device. The diaminopyrene derivative emits light with electrical energy. In the formula, X and X? each independently represent a substituent containing at least one of Ge, P, B and Si. d and e each represent an integer of 0 to 5 while d+e?1 is satisfied. When d is 2 or more, the plurality of X may be mutually the same or different and may be bonded together to form a saturated or unsaturated ring. When e is 2 or more, the plurality of X? may be mutually the same or different and may be bonded together to form a saturated or unsaturated ring.Type: ApplicationFiled: May 7, 2008Publication date: August 11, 2011Applicant: IDEMITSU KOSAN CO., LTD.Inventor: Masakazu Funahashi
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Publication number: 20110195930Abstract: To provide a novel pesticide. The present invention provides a pesticide which contains, as an active ingredient, novel pyridine derivative represented by the formula (I) or its salt: wherein R1 is alkyl, cycloalkyl, alkoxyalkyl or OR3; R2 is 1H-1,2,4-triazol-1-yl which may be substituted, 1H-imidazol-1-yl which may be substituted, 1H-1,2,3-triazol-1-yl which may be substituted, or 4H-1,2,4-triazol-4-yl which may be substituted; X is alkyl which may be substituted, cycloalkyl which may be substituted, halogen, nitro, etc.; R3 is alkyl which may be substituted, cycloalkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, etc.; m is an integer of from 1 to 4.Type: ApplicationFiled: November 6, 2009Publication date: August 11, 2011Applicant: Ishihara Sangyo Kaisha, Ltd.Inventors: Takahiro Haga, Masayuki Morita, Kazuhisa Kiriyama, Kumiko Azuma
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Publication number: 20110183938Abstract: The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.Type: ApplicationFiled: December 14, 2010Publication date: July 28, 2011Applicant: Genentech, Inc.Inventors: Hazel Joan Dyke, Lewis Gazzard, Karen Williams
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Publication number: 20110165346Abstract: Classes of liquid aminosilanes have been found which allow for the production of silicon carbo-nitride films of the general formula SixCyNz. These aminosilanes, in contrast, to some of the precursors employed heretofore, are liquid at room temperature and pressure allowing for convenient handling. In addition, the invention relates to a process for producing such films. The classes of compounds are generally represented by the formulas: and mixtures thereof, wherein R and R1 in the formulas represent aliphatic groups typically having from 2 to about 10 carbon atoms, e.g., alkyl, cycloalkyl with R and R1 in formula A also being combinable into a cyclic group, and R2 representing a single bond, (CH2)n, a ring, or SiH2.Type: ApplicationFiled: March 18, 2011Publication date: July 7, 2011Applicant: AIR PRODUCTS AND CHEMICALS, INC.Inventors: Manchao Xiao, Arthur Kenneth Hochberg
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Patent number: 7968664Abstract: The invention described herein provides for novel nitric oxide-releasing polymers that comprise at least two adjacent units derived from acrylonitrile monomer units and containing at least one carbon-bound diazeniumdiolate. The diazeniumdiolated acrylonitrile-derived polymers can be used in medical devices therapeutically. Accordingly, the invention also provides a method of treating a biological disorder and a method of promoting angiogenesis that includes administering a medical device comprising a nitric oxide-releasing polymer comprising at least two adjacent units of acrylonitrile before exposure to nitric oxide and at least one nitric oxide releasing N2O2— group, wherein the N2O2— group is attached directly to the polyacrylonitrile backbone, to a specific location on or within the mammal in an amount effective to treat the biological disorder or promote angiogenesis.Type: GrantFiled: September 27, 2005Date of Patent: June 28, 2011Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Joseph A. Hrabie, Michael L. Citro, Frank DeRosa, Larry K. Keefer
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Patent number: 7968715Abstract: The present invention relates to a light-emitting transition metal compound represented by the Chemical Formula 1 and Chemical Formula 2 and an organic electroluminescence device including the same. In the Chemical Formulae 1 and 2, M is Ir, Pt, Rh, Re, Os, and the like, m is 2 or 3, n is 0 or 1, the sum of m and n is 3, provided that the sum of m and n is 2 when M is Pt, X, and Z are the same or different, N or P, and Y and Q are O, S, or Se, R1 and R5 are hydrogen, a C1 to C20 alkyl excluding an aromatic cyclic substituent, a cycloalkyl, a halogen, a linear or branched substituent including at least one halogen, or a linear or branched substituent including at least one heteroatom, and R2, R3, R4, R6, R7, R8, R9, and R10 are hydrogen, a C1 to C20 alkyl, an aryl, a cycloalkyl, a halogen, a linear or branched substituent including at least one halogen, a linear or branched substituent including at least one heteroatom, carbonyl, vinyl, or acetylenyl, or may form a cycle, and may be the same or different.Type: GrantFiled: January 8, 2007Date of Patent: June 28, 2011Assignees: Samsung Electronics Co., Ltd., Industry-University Cooperation Foundation, Hanyang UniversityInventors: Dong-Hack Suh, Jin-Soo Lim, Ji-Ho Kim, Sun-Hyun Choi
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Publication number: 20110144291Abstract: The present invention relates to the field of group 4 post-metallocene complexes based on sterically encumbered bis(naphtoxy)pyridine and bis(naphtoxy)thiophene ligands. It also relates to the use of such post-metallocene complexes in the polymerisation of ethylene and alpha-olefins.Type: ApplicationFiled: February 17, 2009Publication date: June 16, 2011Applicants: TOTAL PETROCHEMCALS RESEARCH FELUY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Jean-Francois Carpentier, Evgueni Kirillov, Abbas Razavi
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Publication number: 20110143966Abstract: Novel processes are disclosed for forming an array of polymers by functionalizing the surface of particles by methods that include covalently attaching a functionalized silicon compound. Substrates such as microparticles having functionalized silicon compounds attached thereto are produced by introducing at least one carboxyl group directly by silanating a carboxylated silane compound to the surface of a microparticle. In a further aspect of the invention, the silane compound is a dipodal carboxylated silane.Type: ApplicationFiled: August 2, 2010Publication date: June 16, 2011Applicant: Affymetrix, INC.Inventors: Glenn H. McGall, Anthony D. Barone
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Publication number: 20110143967Abstract: Novel processes are disclosed for forming an array of polymers by functionalizing the surface of particles by methods that include covalently attaching a functionalized silicon compound. Substrates such as microparticles having functionalized silicon compounds attached thereto are produced by introducing at least one carboxyl group directly by silanating a carboxylated silane compound to the surface of a microparticle. In a further aspect of the invention, the silane compound is a dipodal carboxylated silane.Type: ApplicationFiled: December 14, 2010Publication date: June 16, 2011Inventors: Glenn H. McGALL, Anthony D. BARONE, Randall J. TRUE
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Publication number: 20110127513Abstract: The present invention provides a novel nitrogen-containing heterocyclic derivative and an organic electronic device using the same. The organic electronic device according to the present invention has excellent properties in terms of efficiency, driving voltage, and a life span.Type: ApplicationFiled: November 3, 2009Publication date: June 2, 2011Applicant: LG CHEM, LTD.Inventors: Dong-Hoon Lee, Tae-Yoon Park, Jae-Soon Bae, Hyun Nam, Jun-Gi Jang, Sung-Kil Hong
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Publication number: 20110130361Abstract: The present invention relates to a novel class of Silicon derivatives. The Silicon compounds can be used to treat cancer. The Silicon compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.Type: ApplicationFiled: August 5, 2008Publication date: June 2, 2011Inventors: Jonathan Grimm, Richard W. Heidebrecht, JR., Dawn M. Mampreian, Joey L. Methot, Thomas A. Miller, Karin M. Otte, Scott Peterson, Phieng Siliphaivanh, Kevin J. Wilson, David J. Witter
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Publication number: 20110112297Abstract: The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.Type: ApplicationFiled: June 19, 2009Publication date: May 12, 2011Applicant: Chongqing Pharmaceutical Research Institute Co., Ltd.Inventors: Huafu Sun, Jie Luo, Wenrun Ye, Jie Deng, Bo Lin, Chunyan Dan, Bin Fan
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Publication number: 20110108781Abstract: The present invention relates to photochromic materials that include a photochromic compound that includes a photochromic substituent (e.g., an indeno-fused naphthopyran) and at least one pendent silane group, which is bonded to the photochromic substituent. The pendent silane groups are selected from certain pendent siloxy-silane groups and/or pendent alkoxy-silane groups represented by general formulas (I) and/or (II) as described in further detail herein. The present invention also relates to photochromic articles, such as photochromic optical elements (e.g., photochromic lenses), and photochromic coating compositions (e.g., curable photochromic coating compositions), that include the photochromic materials of the present invention. The photochromic materials of the present invention have improved compatibility with compositions into which they may be incorporated, for example, coating compositions, such as urethane coating compositions.Type: ApplicationFiled: October 26, 2010Publication date: May 12, 2011Applicant: TRANSITIONS OPTICAL, INC.Inventor: Massimiliano Tomasulo
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Publication number: 20110105430Abstract: Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (A) are inhibitors N of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.Type: ApplicationFiled: June 8, 2009Publication date: May 5, 2011Inventors: Soumya P. Sahoo, Meng-Hsin Chen, Kevin D. Dykstra, Hiroo Koyama, Peter T. Meinke, Stephen J. O'keefe, Ginger Xu-Qiang Yang
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Publication number: 20110105704Abstract: The present invention discloses post-metallocene complexes based on sterically encumbered bi- and tri-dentate naphthoxy-imine ligands. It also relates to the use of such post-metallocene complexes in the oligomerisation of ethylene to selectively prepare vinyl-end capped linear alpha-olefins.Type: ApplicationFiled: April 24, 2009Publication date: May 5, 2011Applicants: TOTAL PETROCHEMICALS RESEARCH FELUY, Centre National De Le Recherche Scientifique (CNRS)Inventors: Jean-Francois Carpentier, Evgueni Kirillov, Abbas Razavi
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Publication number: 20110105429Abstract: The use of thiazole-4-carboxylic esters and thioesters of the formula (I) in which R1, R2, R3, R4, R5, R6, R7, Y1, Y2, Y3, W, X and G have the meanings given in the description, and also of agrochemically active salts thereof, as fungicides.Type: ApplicationFiled: April 18, 2009Publication date: May 5, 2011Applicant: Bayer CropScience AGInventors: Pierre Cristau, Stefan Harrmann, Nicola Rahn, Arnd Voerste, Ulrik Wachendorff-Neumann, Tomoki Tsuchiya
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Publication number: 20110092672Abstract: A nanoparticle contains a core including superparamagnetic nanoparticles and having an outer surface, and siloxanyl moieties covalently coupled to the outer surface of the core and having Formula (I): In formula (I): X1 and X2 independently represent methylene, ethylene or propylene; R represents an optionally substituted pyridyl group, or —S—R is a group derived from a targeting ligand containing —SH group and effective to bind specifically with a predetermined targeted cell in an object; n and m independently represent an integer ranging from 1 to 3; and p represents an integer ranging from 9 to 45. The nanoparticles are suitable for use as a magnetic resonance imaging contrast agent.Type: ApplicationFiled: April 14, 2010Publication date: April 21, 2011Applicant: NATIONAL CHIAO TUNG UNIVERSITYInventors: Yun-Ming Wang, Ting-Jung Chen
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Publication number: 20110077404Abstract: The invention relates to a novel process for the preparation of pharmacologically interesting indolopyridine derivatives containing tetracyclic tetrahydro-?-carboline-hydantoines linked to a basic side chain and the corresponding salts, which can be used as Eg5 inhibitor, with very high overall chemical yield and enantiomeric purity.Type: ApplicationFiled: March 5, 2009Publication date: March 31, 2011Applicant: 4SC AGInventors: Bernd Muller, Helmut Schlemper
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Publication number: 20110077220Abstract: The present invention is directed to compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.Type: ApplicationFiled: April 23, 2009Publication date: March 31, 2011Inventors: Scott D. Kuduk, Christina Ng Di Marco, William D. Shipe
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Patent number: 7914910Abstract: An organic electroluminescence device includes an anode; a cathode; and at least one organic layer, wherein the at least one organic layer includes a first organic layer which is a light-emitting layer being provided between the anode and the cathode and containing at least one light-emitting material, and the at least one organic layer contains at least one compound represented by formula (I): wherein Q1 represents an aromatic heterocyclic ring; each of R1, R2, R3 and R4 independently represents a hydrogen atom or a substituent; and each of R11, R12 and R13 independently represents an alkyl group, an aryl group, or an aromatic heterocyclic group, provided that at least one of R11, R12 and R13 represents an aryl group or an aromatic heterocyclic group.Type: GrantFiled: November 26, 2008Date of Patent: March 29, 2011Assignee: FUJIFILM CorporationInventor: Toshihiro Ise
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Publication number: 20110065745Abstract: Compounds of formula (I): wherein R, R1, R2, R3, R4, and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.Type: ApplicationFiled: September 14, 2010Publication date: March 17, 2011Applicant: SANOFI-AVENTISInventors: Danielle DE PERETTI, Yannick EVANNO, Patrick LARDENOIS, Nathalie RAKOTOARISOA, Antonio ALMARIO GARCIA, Andre MALANDA
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Publication number: 20110065700Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.Type: ApplicationFiled: September 14, 2010Publication date: March 17, 2011Applicant: SANOFI-AVENTISInventors: Danielle DE PERETTI, Yannick EVANNO, David MACHNIK, Nathalie RAKOTOARISOA
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Publication number: 20110065727Abstract: Compounds of formula (I): wherein R, R1, R2, R3, R4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.Type: ApplicationFiled: September 14, 2010Publication date: March 17, 2011Applicant: SANOFI-AVENTISInventors: Danielle DE PERETTI, Yannick EVANNO, Patrick LARDENOIS, David MACHNIK, Nathalie RAKOTOARISOA, Antonio ALMARIO GARCIA
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Publication number: 20110046336Abstract: A transition metal complex obtained by contacting a bipyridine compound represented by the formula (1): wherein R1, R2 and R3 represent a C1-C10 alkyl group which may be substituted, etc., and R4 and R5 represent a hydrogen atom etc., with a compound of a transition metal belonging to Group 9, 10 or 11, and a process for producing a conjugated aromatic compound comprising reacting an aromatic compound (A) wherein one or two leaving groups are bonded to an aromatic ring with an aromatic compound (A) having the same structure as that of the above-mentioned aromatic compound (A) or an aromatic compound (B) being structurally different from the above-mentioned aromatic compound (A) and having one or two leaving groups bonded to an aromatic ring, in the presence of said transition metal complex.Type: ApplicationFiled: July 25, 2008Publication date: February 24, 2011Inventors: Taku Asaumi, Takashi Kamikawa
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Publication number: 20110046088Abstract: Compounds of the formula (I) in which the substituents are as defined in claim 1 are suitable for use as microbiocides.Type: ApplicationFiled: February 20, 2008Publication date: February 24, 2011Applicants: SYNGENTA CROP PROTECTION, INC., SYNGENTA LIMTIEDInventors: Paul Anthony Worthington, Daniel Stierli, Fredrik Cederbaum, Kurt Nebel, Antoine Daina
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Publication number: 20110024725Abstract: The present invention relates to a novel anthracene derivative and an organic electronic device using the same. The organic electronic device according to the present invention shows excellent characteristics in efficiency, driving voltage, and life time.Type: ApplicationFiled: May 16, 2008Publication date: February 3, 2011Inventors: Dong-Hoon Lee, Jae-Chol Lee, Jae-Soon Bae, Jun-Gi Jang, Kong-Kyeom Kim, Dae-Woong Lee
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Patent number: 7875717Abstract: The present invention relates to a light emitting metallic compound of Chemical Formula 1 and an organic electroluminescence device including the compound. In the Chemical Formula 1, M is selected from Ir, Pt, Rh, Re, and Os, m is 2 or 3, n is 0 or 1, the sum of m and n is 3, provided that the sum of m and n is 2 when M is Pt. X is an N or P atom, Y is S, O, or Se, and Z is SiR5R6, CR5R6, PR5, S, SO2, carbonyl, or NR5, and L2 is represented by Chemical Formulae 2, 3, or 4.Type: GrantFiled: January 8, 2007Date of Patent: January 25, 2011Assignees: Samsung Electronics Co., Ltd., Industry-University Cooperation Foundation, Hanyang UniversityInventors: Dong-Hack Suh, Jin-Sik Choi, Song-Ho Kim, Dae-Beom Kim, Chi-Hun Kim