Publication number: 20100022527
Abstract: The present invention relates to novel substituted spirotetronic acids (I) in which R1 and R2, together with the carbon atom to which they are bonded, form a group of the formula (1), (2), (3) or (4), whereby * represents the carbon atom to which R1 and R2 are bonded, to methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of retroviral disorders, in people and/or animals.
Type:
Application
Filed:
February 25, 2009
Publication date:
January 28, 2010
Applicant:
AiCuris GMBH & Co. KG
Inventors:
Dirk HEIMBACH, Adrian TERSTEEGEN, Kai THEDE, Reinhold WELKER, Beate FAST, Arnold PAESSENS, Frank DITTMER, Rudolph SCHOHE-LOOP, Axel HARRENGA, Alexander HILLISCH, Kerstin HENNINGER, Walter HUEBSCH, Marcus BAUSER, Daniela PAULSEN, Alexander BIRKMANN, Thomas BRETSCHNEIDER, Reiner FISCHER, Susanne GRESCHAT, Andreas URBAN, Steffen WILDUM
Publication number: 20090325992
Abstract: A compound represented by general formula (I): a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, macular degeneration, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, cancerous diseases (for example, cancer, cancer metastasis, etc.), a preventive and/or therapeutic agent for cancerous diseases or infections, or an agent for regeneration therapy.
Type:
Application
Filed:
July 30, 2007
Publication date:
December 31, 2009
Applicant:
ONO PHARMACEUTICAL CO., LTD.
Inventors:
Keisuke Hanada, Masaya Kokubo, Hiroshi Ochiai, Kousuke Tani, Shiro Shibayama
Publication number: 20090192182
Abstract: A compound represented by general formula (I): a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification. The compound of the present invention has antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, systemic erythematosus, retinopathy, macular degeneration, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
Type:
Application
Filed:
May 15, 2007
Publication date:
July 30, 2009
Applicant:
ONO PHARMACEUTICAL CO.,LTD.
Inventors:
Kensuke Kusumi, Masaya Kokubo, Hiroshi Ochiai, Shiro Shibayama
Publication number: 20090169567
Abstract: A compound represented by general formula (I): a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, systemic erythematosus, retinopathy, macular degeneration, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiac /vascular disease (for example, arteriosclerosis, myocardial infarction, stenocardia, cerebral infarction, chronic arterial occlusive disease, etc.), metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.
Type:
Application
Filed:
November 17, 2006
Publication date:
July 2, 2009
Applicant:
ONO PHARMACEUTICAL CO., LTD.,
Inventors:
Masaya Kokubo, Hiroshi Ochiai, Yoshikazu Takaoka, Shiro Shibayama
Publication number: 20090118279
Abstract: The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
Type:
Application
Filed:
October 27, 2006
Publication date:
May 7, 2009
Applicant:
ONO PHARMACEUTICAL CO., LTD.,
Inventors:
Masaya Kokubo, Motoyuki Tanaka, Hiroshi Ochiai, Yoshikazu Takaoka, Shiro Shibayama