Having -c(=x)-, Wherein X Is Chalcogen, Attached Indirectly To A Piperdine Ring By Nonionic Bonding Patents (Class 546/190)
  • Patent number: 4976889
    Abstract: 4-Formylaminopiperidine derivatives of the formula (I) ##STR1## where n is 1 or 2, R.sup.1 to R.sup.4 are each alkyl or R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 are tetra- or pentamethylene, R.sup.5 is hydrogen or alkyl, R.sup.6 is hydrogen, unsubstituted or substituted alkyl, alkenyl, aralkyl or acyl, and, when n is 1, Y is hydrogen, unsubstituted or substituted alkyl, alkenyl, cycloalkyl, bicycloalkyl, aralkyl, aryl, alkyl containing heterocyclic radicals, or ##STR2## or, when n is 2, Y is alkylene, cycloalkylene, aralkylene or arylene or is alkylene which is interrupted by oxygen, nitrogen, sulfur or a 5-membered or 6-membered heterocyclic structure, and their acid addition salts have very good stabilizing properties in plastics.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: December 11, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Alexander Aumueller, Peter Neumann, Hubert Trauth
  • Patent number: 4973756
    Abstract: An alpha-hydroxyl-alpha,alpha-di(inert-substituted)-gamma',delta'-yne ketone can be prepared by a procedure comprising contacting an acetylenic Grignard reagent with an alpha-hydroxyl-alpha,alpha-di(inert substituted)-alpha',beta'-ene ketone, and the alpha-hydroxyl-alpha,alpha-di(inert-substituted)-alpha',beta'-ene ketone can be prepared by a procedure comprising steps of contacting, first, an alkoxy allene with a lithium donating organic agent, second, product of the first step with a di(inert-substituted)ketone, and third, product of the second step with an acidic substance.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: November 27, 1990
    Assignee: Marion Laboratories, Inc.
    Inventors: Hans Wynberg, Wolter T. Hoeve, Gerrit A. Barf, Johannes N. Koek, David R. Borcherding
  • Patent number: 4972009
    Abstract: Compounds possessing both a hindered amine moiety, such as a derivative of 2,2,6,6-tetramethylpiperidine, and a nitrone moiety are valuable stabilizers for protecting polymer compositions against the deleterious effects of actinic light and from the adverse effects of high temperature polymer processing environments. Additionally, the instant compounds present the opportunity for grafting onto preformed polymer backbones.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: November 20, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Joseph Suhadolnik, Ramanathan Ravichandran
  • Patent number: 4970022
    Abstract: Mustard oils of the formula IR--(A.sup.1 --Z.sup.1).sub.n --A.sup.2 --Z.sup.2 --A.sup.3 --NCSin which A.sup.1, A.sup.2, A.sup.3, R, Z.sup.1, Z.sup.2 and n have the meaning specified in claim 1 can be used as components of liquid-crystalline phases.
    Type: Grant
    Filed: August 19, 1987
    Date of Patent: November 13, 1990
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Bernhard Scheuble, Rudolf Eidenschink, Joachim Krause, Eike Poetsch, Andreas Wachtler
  • Patent number: 4933344
    Abstract: Ethanone oximes represented by the following general formula: ##STR1## wherein R.sup.1 represents a cycloalkyl group, aryl group, aralkyl group, aryloxy group, aralkyloxy group, arylthio group or aryl sulfonyl group, those groups being optionally substituted with a substituent selected from an alkyl group having 1 to 3 carbon atoms, an alkoxy group having 1 to 3 carbon atoms and a halogen atom, piperidino group, piperazino group, 4-alkyl substituted piparazino group, imidazolyl group, 4-alkyl substituted imidazolyl group or substituted amino group,R.sup.2 represents a hydrogen atom or an alkoxy group having 1 to 3 carbon atoms, andR.sup.3 represents a piperidino group, piperazino group or 4-alkyl substituted piperazino group, orR.sup.1 and R.sup.2 together with a phenyl group to which they are attached may form a phenothiazin-2-yl group, N-acetyl-phenothiazin-2-yl group, thianthren-2-yl group, dibenzothiophen-3-yl group, dibenzofuran-3-yl group or a group of the formula: ##STR2## wherein R.sup.
    Type: Grant
    Filed: August 31, 1988
    Date of Patent: June 12, 1990
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Shinichiro Fujimori, Satoshi Yamazaki, Mamoru Sugano, Makoto Kawamura, Kunihiro Ninomiya, Akihiro Tobe, Issei Nitta
  • Patent number: 4921893
    Abstract: both R.sub.1 's are CH.sub.3 or together form --CH.sub.2).sub.5 ;both R.sub.2 's are CH.sub.3 or together form --CH.sub.2).sub.5 ;R.sub.3 has a significance of R, independently of R, except for oxygen;X is --O--, --NH-- or ##STR2## m is an integer from 1 to 4 inclusive; R.sub.4 is a saturated or unsaturated aliphatic group unsubstituted or substituted by one or two groups selected from --OH and C.sub.1-4 alkoxy and which can be interrupted by an oxygen or sulphur atom; or an aromatic group unsubstituted or substituted by one or two groups selected from --OH, C.sub.1-4 alkyl and C.sub.1-4 alkoxy are useful as U.V. light stabilizers in polymeric organic compounds.
    Type: Grant
    Filed: December 3, 1987
    Date of Patent: May 1, 1990
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4916175
    Abstract: Compounds are provided which are useful as light stabilizers for polymeric materials and which have the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are organic radicals, R.sub.3 and R.sub.15 are hydrogen or organic radicals and R is hydrogen, oxygen or an organic radical.
    Type: Grant
    Filed: November 5, 1987
    Date of Patent: April 10, 1990
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4914227
    Abstract: A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula: ##STR1## which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: ##STR2## with a benzylidene compound represented by the general formula: ##STR3## (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde compound represented by the general formula: ##STR4## and a .beta.-keto-ester compound represented by the general formula:R.sup.4 --CO--CH.sub.2 --COOR.sup.2 (V)(c) reacting a 3-carbamoyloxyalkylpropiolic acid derivative represented by the general formula: ##STR5## with the benzylidene compound of the general formula III and ammonia or its salt; or(d) reacting the 3-carbamoyloxyalkylpropiolic acid derivative of the general formula VI with the aldehyde compound of the general formula IV, the .beta.-keto-ester compound of the general formula V and ammonia or its salt.
    Type: Grant
    Filed: May 16, 1986
    Date of Patent: April 3, 1990
    Assignee: Banyu Pharmaceutical Company, Ltd.
    Inventors: Tetsuji Miyano, Kunio Suzuki, Ryosuke Ushijima, Susumu Nakagawa
  • Patent number: 4906634
    Abstract: Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents, especially as antiarrhythmic agents are described. Pharmaceutical formulations containing such compounds are also discussed.
    Type: Grant
    Filed: March 8, 1988
    Date of Patent: March 6, 1990
    Assignee: Schering A.G.
    Inventors: Stanley S. Greenberg, William C. Lumma, Jr., Klaus Nickisch, Ronald A. Wohl
  • Patent number: 4902334
    Abstract: A plant metabolism regulating agent comprising as an active ingredient an alpha,beta or beta,gamma-un-saturated carboxylic acid or its derivative. It is useful for controlling the metabolism of a plant, facilitating the growth of a beneficial plant such as cereals by inhibiting the growth of undesirable plants or eradicating them, regulating the growth of a plant and dwarfing a plant.
    Type: Grant
    Filed: October 31, 1984
    Date of Patent: February 20, 1990
    Assignee: Teijin Limited
    Inventors: Shizuo Azuma, Toshiyuki Hiramatsu, Teizo Yamaji, Yataro Ichikawa
  • Patent number: 4898941
    Abstract: A process for preparing a diphenylalkene derivative of the formula [II] ##STR1## which comprises oxidizing a diphenylalkanoic acid derivative of the formula [I] ##STR2## wherein R.sub.1 and R.sub.2 are each substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or substituted or unsubstituted aryl, R.sub.1 and R.sub.2 may form a heteroring together theirwith or with an adjacent benzene ring, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 are each hydrogen atom, halogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyl or substituted or unsubstituted amino, R.sub.12 and R.sub.13 are each hydrogen atom or substituted or unsubstituted alkyl, X is carboxyl, amide, ester or halide thereof.
    Type: Grant
    Filed: August 11, 1987
    Date of Patent: February 6, 1990
    Assignee: Kanzaki Paper Manufacturing Co., Ltd.
    Inventors: Nobuo Kanda, Haruo Omura, Yukihiro Abe, Mitsuru Kondo
  • Patent number: 4876279
    Abstract: Novel 3-hydroxy-3-methylglutaryl-Coenzyme A(HMG-CoA) reductase inhibitors, which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II) ##STR1## and pharmaceutically acceptable salts of the compound (II) in which Z is hydrogen are disclosed.
    Type: Grant
    Filed: May 26, 1988
    Date of Patent: October 24, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Ta J. Lee, William F. Hoffman, Clarence S. Rooney
  • Patent number: 4873253
    Abstract: A phenylalanine derivative having the formula (I): ##STR1## wherein A represents ##STR2## B represents ##STR3## wherein m is 0, 1, or 2 and n is 3, 4, or 5; X represents (a) hydroxy, (b) nitro, (c) amino, (d) phenoxy which may be substituted with (i) halogen or (ii) nitro, (e) c.sub.1 -C.sub.4 alkyloxy which may be substituted wit (i) phenyl or (ii) benzoyl, (f) benzoyl, (g) pyridyloxy which may be substituted with (i) halogen or (ii) nitro, or (h) c.sub.1 -C.sub.4 alkyl which may by substituted with halogen;Y represents ##STR4## or --OR.sup.3 wherein R.sup.1 R.sup.2 are independently (a) hydrogen, (b) phenyl which may be substituted with (i) benzoyl, (ii) C.sub.1 -C.sub.4 alkylcarbonyl, (iii) C.sub.1 -C.sub.4 alkyl which may be further substituted with C.sub.1 -C.sub.4 alkoxycarbonyl or hydroxycarbonyl, (iv) C.sub.2 -C.sub.5 alkenyl which may be further substituted with hydroxycarbonyl or C.sub.1 -C.sub.4 alkoxycarbonyl, (v) C.sub.1 -C.sub.
    Type: Grant
    Filed: March 30, 1987
    Date of Patent: October 10, 1989
    Assignees: Shosuke Okamoto, Showa Denko Kabushiki Kaisha
    Inventors: Shosuke Okamoto, Yoshio Okada, Akiko Okunomiya, Taketoshi Naito, Yoshio Kimura, Morihiko Yamada, Norio Ohno, Yasuhiro Katsuura, Hiroshi Nojima, Takashi Shishikura
  • Patent number: 4857643
    Abstract: 2-Substituted thiazolidines compounds having formula I ##STR1## wherein X is a CH.sub.2, O or S, R is hydroxy or an acyloxy, alkyloxy, alkenyloxy or alkinyloxy group, R.sub.1 is hydrogen or a group of formula ##STR2## R.sub.2 is hydrogen or a free or esterified carboxy group, R.sub.a and R.sub.b are hydrogen or methyl, p is zero or 1, R.sub.3 is hydrogen, a C.sub.1 -C.sub.2 alkylsulphonyl group, a phenyl or p-Cl phenyl, p-methylsulphonyl group or an acyl group; are useful as mucus regulating, antitussive and antibronchospastic agents.
    Type: Grant
    Filed: November 3, 1988
    Date of Patent: August 15, 1989
    Assignee: Boehringer Biochemia Robin S.p.A.
    Inventors: Carmelo A. Gandolfi, Silvano Spinelli, Odoardo Tofanetti, Raimondo Russo, Sergio Tognella
  • Patent number: 4855434
    Abstract: The novel compounds of the formula (I) ##STR1## in which n is 1 or 2, R.sub.1 is hydrogen, 0.sup..multidot. NO, cyanomethyl, C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.6 alkenyl or C.sub.3 -C.sub.6 alkynyl subject to the proviso that the carbon atom attached to the nitrogen atom is a primary carbon atom, benzyl, C.sub.1 -C.sub.7 acyl or OH-monosubstituted C.sub.2 -C.sub.4 alkyl, R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkyl or phenyl, R.sub.3 is a group of the formula (II) ##STR2## with R.sub.6 being as defined for R.sub.1, R.sub.4 is --COOR.sub.3 or --CN and, if n is 1, R.sub.5 is hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.2 -C.sub.4 alkyl substituted by C.sub.1 -C.sub.12 alkoxy or di(C.sub.1 -C.sub.6 alkyl)amino, or C.sub.5 -C.sub.12 cycloalkyl unsubstituted or substituted by 1, 2 or 3 C.sub.1 -C.sub.4 alkyl radicals, benzyl, benzyl substituted by 1, 2 or 3 C.sub.1 -C.sub.4 alkyl radicals, or a group of the formula (II), and, if n is 1 and R.sub.4 is --CN, R.sub.
    Type: Grant
    Filed: February 16, 1988
    Date of Patent: August 8, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Giuseppe Cantatore, Valerio Borzatta
  • Patent number: 4847380
    Abstract: Novel high molecular weight polyalkoxyamine derivatives are prepared which contain a polyalkoxyamide, urea or urethane backbone with a piperidine terminal radical.The structures can be represented by the following three classes of compounds: ##STR1## where R.sub.1 is from dibasic acid, e.g. adipic or dimer acid; R.sub.2 is from diisocyanate, e.g. IPDI or TMXDI.
    Type: Grant
    Filed: July 27, 1987
    Date of Patent: July 11, 1989
    Assignee: Texaco Inc.
    Inventors: George P. Speranza, Jiang-Jen Lin
  • Patent number: 4837350
    Abstract: Benzoin esters of aromatic sulfonic acids can be obtained in high yield from benzoin and the respective sulfonyl halide in molar amounts of a base by carrying out the reaction at low temperature in an organic solvent with the addition of water. Aqueous NaOh or KOH can be used as base in this process.
    Type: Grant
    Filed: December 7, 1987
    Date of Patent: June 6, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Rutsch, Rinaldo Husler
  • Patent number: 4822883
    Abstract: Compounds which contain peroxide linkages and the radical of a hindered amine light stabilizer group are provided. These compounds function as polymerization initiators which cause the hindered amine stabilizer to be chemically bound to the polymer.
    Type: Grant
    Filed: August 20, 1987
    Date of Patent: April 18, 1989
    Assignee: Pennwalt Corporation
    Inventor: Terry N. Myers
  • Patent number: 4788187
    Abstract: A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: November 29, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Patent number: 4780493
    Abstract: Novel piperidine compounds of the general formula (I) ##STR1## in which m is an integer from 1 to 4, R.sub.1 and R.sub.2 are as defined in claim 1 and at least one 2,2,6,6-tetramethylpiperidinyl group, being present in R.sub.1 or R.sub.2 are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic material, especially for synthetic polymers.
    Type: Grant
    Filed: April 22, 1986
    Date of Patent: October 25, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Giuseppe Cantatore, Valerio Borzatta
  • Patent number: 4772708
    Abstract: Derivatives of 4-hydroxy-methyl-piperidine having general formula: ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be alkyl or may form, with the carbon they are bound to, a cycloalkyl group or the group ##STR2## with R.sub.6, R.sub.7, R.sub.8 and R.sub.9 being hydrogen or alkyl; R.sub.5 may be H, alkyl, aryl, alkenyl, etc.; Y may be an organic or inorganic group or atom having a valence from 1 to 4 and n is an integer from 1 to 4.The use of the derivatives of the alkyl-substituted 4-hydroxy-methyl-piperidine of formula (I) as stabilizers of polymeric substances, and polymeric compositions stabilized with said piperdine derivatives.This invention relates to new derivatives of alkyl-substituted 4-hydroxy-methyl-piperidine, to the use thereof as stabilizers of polymeric substances usually subject to worsening owing to thermal and/or photo-oxidation, and to the polymeric compositions stabilized with said derivatives.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: September 20, 1988
    Assignee: Ausimont S.p.A.
    Inventors: Piero Di Battista, Gilberto Nucida
  • Patent number: 4762872
    Abstract: A poly(.alpha.-aminoacetamide) ("poly(AAMID)" for brevity) main chain having terminal polysubstituted piperidinyl chain ends are novel compounds which have highly desirable UV-light stabilizing (UV-S) activity coupled with unexpectedly good thermal stability. These compounds, referred to as "piperidinyl-chain ended poly(AAMID)s", are oligomers which contain from 2 to about 18 AAMID repeating units, for use in polymer recipes to formulate a stabilized polymeric composition comprising a UV-light-degradable organic polymer containing an effective amount of the poly(AAMID) sufficient to stabilize the polymer. A poly(AAMID) is especially effective in a polyolefin in which there is from about 0.1 percent by weight (% by wt), to about 5% by wt of the oligomer, and is also effective in a wide variety of pastel colored and/or transparent commercially significant polymers.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: August 9, 1988
    Assignee: The B. F. Goodrich Company
    Inventors: John T. Lai, Pyong Nae-Son
  • Patent number: 4760061
    Abstract: Mono- or bis-complex esters or ethers of a phenol derivative of the formulaNU--A--X--R.sup.1wherein NU is a defined mono- or bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus; whereinA is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, whereinR.sup.1 is hydrogen, or alkyl, alkenyl, cycloalkyl, halogenoalkyl, aryl or arylalkyl, or R.sup.1 is joined to R.sup.2, and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR1## --SO.sub.2 NR.sup.2 -- or --CO--, or, when R.sup.1 is not hydrogen, is --NR.sup.12 COO--, --S--, --SO-- or --SO.sub.2 --, whereinR.sup.2 is hydrogen or alkyl, or R.sup.1 and R.sup.2 together form alkylene; whereinR.sup.12 is hydrogen or alkyl, and whereinR.sup.22 is hydrogen, cyano or nitro; or a salt thereof when appropriate.
    Type: Grant
    Filed: April 24, 1985
    Date of Patent: July 26, 1988
    Assignee: Imperial Chemical Industries PLC
    Inventors: Philip N. Edwards, Brian S. Tait
  • Patent number: 4751073
    Abstract: 2,2,6,6-tetraalkyl-4-piperidinyl derivatives and, more specifically, the N,N'-bis(2,2,6,6-tetraalkyl-4-piperidene)2,2'-diamino-2,2'-dihydrocarbyl divinyl ketones wherein the alkyl groups have independently from one to about eight carbon atoms and said hydrocarbyl moieties are selected from the group consisting of alkyls having between one and about eight carbon atoms, aryl, alkaryl, and aralkyl groups having between one and about twenty carbon atoms.These compounds are useful as UV light stabilizers in plastics and cosmetics (e.g. sunscreens).
    Type: Grant
    Filed: June 3, 1987
    Date of Patent: June 14, 1988
    Assignee: Olin Corporation
    Inventor: Robert J. Raynor
  • Patent number: 4751310
    Abstract: Compounds having the formula ##STR1## wherein n is 0 or 1, R.sup.2 through R.sup.9 are H or C.sub.1-2 alkyl, and X is pyridyl or mono- or disubstituted phenyl are useful in the preparation of the compounds which inhibit the 5-lipoxygenase pathway.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: June 14, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul E. Bender, Nabil Hanna
  • Patent number: 4748184
    Abstract: The present invention relates to new compounds of the formula ##STR1## wherein X is ##STR2## wherein R.sub.1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole, pyrazole oxazole or thiazole; W is hydrogen or hydroxy; (Y).sub.A is positioned ortho to W and is an aminoloweralkyl having the formula --CH.sub.2 NR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 are the same or different and may be lower alkyl or R.sub.2 and R.sub.3 may together with N form a pyrrolidine, piperidine or azepine ring, and A is 2; n and m are independently from 0 to 5; and R is straight or branched C.sub.1 -C.sub.10 alkyl, straight or branched C.sub.3 -C.sub.10 cycloalkyl, straight or branched C.sub.2 -C.sub.4 alkenyl or straight or branched C.sub.2 -C.sub.4 alkynyl, or a pharmaceutically acceptable salt thereof.These compounds are useful in the treatment of various cardiac arrhythmias.
    Type: Grant
    Filed: December 27, 1985
    Date of Patent: May 31, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David M. Stout, William L. Matier, Lawrence A. Black
  • Patent number: 4739106
    Abstract: A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula: ##STR1## which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: ##STR2## with a benzylidene compound represented by the general formula: ##STR3## (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde compound represented by the general formula: ##STR4## and a .beta.-keto-ester compound represented by the general formula:R.sup.4 --CO--CH.sub.2 --COOR.sup.2 (V)(c) reacting a 3-carbamoyloxyalkylpropiolic acid derivative represented by the general formula: ##STR5## with the benzylidene compound of the general formula III and ammonia or its salt; or(d) reacting the 3-carbamoyloyalkylpropiolic acid derivative of the general formula VI with the aldehyde compound of the general formula IV, the .beta.-keto-ester compound of the general formula V and ammonia or its salt.
    Type: Grant
    Filed: May 16, 1986
    Date of Patent: April 19, 1988
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Tetsuji Miyano, Kunio Suzuki, Nobuo Harada
  • Patent number: 4730017
    Abstract: A compound useful as a light-stabilizer for polymeric material of formula I ##STR1## in which R is hydrogen, oxygen, C.sub.1-8 alkyl or --CO--R.sub.5, where R.sub.5 is --C(R.sub.10).dbd.CH.sub.2, C.sub.1-6 alkyl, phenyl, --CO--O--C.sub.1-4 alkyl or --NR.sub.7 R.sub.8 and where R.sub.7 is hydrogen, C.sub.1-12 alkyl, C.sub.5-6 -cycloalkyl, phenyl, phenylC.sub.1-4 alkyl or C.sub.1-12 alkylphenyl and R.sub.8 is C.sub.1-12 alkyl or hydrogen;each R.sub.1, independently, is --CH.sub.3 or --CH.sub.2 (C.sub.1-4 alkyl) or both groups R.sub.1 form a group --(CH.sub.2).sub.5 --;each R.sub.2, independently, is --CH.sub.3 or --CH.sub.2 (C.sub.1-4 alkyl) or both groups R.sub.2 form a group --(CH.sub.2).sub.5);R.sub.10 is hydrogen or C.sub.1-4 alkyl; andR.sub.4 is an amide- or ester-forming group.
    Type: Grant
    Filed: September 12, 1986
    Date of Patent: March 8, 1988
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4725634
    Abstract: A stabilizer for synthetic resins containing as an effective ingredient a hindered piperidine compound represented by the general formula: ##STR1## wherein R.sub.1 represents a C.sub.1 -C.sub.18 alkyl group, R.sub.2 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, n represents an integer of 1 to 12, and C.sub.n H.sub.2n represents a straight-chain or branched alkylene group.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: February 16, 1988
    Assignee: Sumitomo Chemical Company, Ltd.
    Inventors: Tamaki Ishii, Shinichi Yachigo, Haruki Okamura, Yuzo Maegawa, Eizo Okino, Yukoh Takahashi, Hiroki Yamamoto
  • Patent number: 4719218
    Abstract: A method of inhibiting the production of 5-lipoxygenase products in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a 2(3)-(pyridyl)-3-(2)-substituted phenyl)-6,7-dihydro-[5H]-pyrrolo-[1,2-a]imidazole, a 2(3)-(pyridyl)-3(2)-(substituted phenyl)-5,6,7,8-tetrahydro-imidazo[1,2,-a]pyridine, or a pharmaceutically acceptable salt thereof, to such animal.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: January 12, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul E. Bender, Nabil Hanna
  • Patent number: 4716187
    Abstract: both R.sub.1 's and CH.sub.3 or together form --CH.sub.2).sub.5 ;both R.sub.2 's are CH.sub.3 or together form --CH.sub.2).sub.5 ;R.sub.3 has a significance of R, independently of R, except for oxygen;X is --O--, --NH-- or ##STR2## m is an integer from 1 to 4 inclusive; R.sub.4 is a saturated or unsaturated aliphatic group unsubstituted or substituted by one or two groups selected from --OH and C.sub.1-4 alkoxy and which can be interrupted by an oxygen or sulphur atom; or an aromatic group unsubstituted or substituted by one or two groups selected from --OH, C.sub.1-4 alkyl and C.sub.1-4 alkoxy are useful as U.V. light stabilizers in polymeric organic compounds.
    Type: Grant
    Filed: March 15, 1985
    Date of Patent: December 29, 1987
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4710527
    Abstract: Malonate-based spiroacetals of polyalkylpiperidin-4-ones are useful light stabilizers for synthetic polymer resins such as polyolefins, and in particular, polypropylene.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: December 1, 1987
    Assignee: ICI Americas Inc.
    Inventors: Richard V. Nelson, John F. Stephen
  • Patent number: 4705805
    Abstract: Certain 2,2'-dithiobis-N-substituted or unsubstituted benzamides or derivatives thereof are useful as antithrombotic agents because of their ability to suppress aggregation of blood platelets.
    Type: Grant
    Filed: February 17, 1987
    Date of Patent: November 10, 1987
    Inventors: Koji Yamada, Tamotsu Hashimoto, Masao Naruse, Yo Murayama, Hideki Ninno
  • Patent number: 4696959
    Abstract: A composition of matter contains as a principal component a material which acts as an ultraviolet light stabilizer. The ultraviolet light stabilizer is formed from the reaction of (a) a methylol or alkoxy alkyl-containing material, and (b) an alkyl substituted piperidine containing material which is represented by the following structural formula: ##STR1## R" is hydrogen or C.sub.1 to C.sub.6 alkyl, R.sub.10 is hydrogen or methyl,Y is a radical derived from a material selected from the group consisting of amino substituted triazines, ureas, glycolurils, phenols, and amides of the formula ##STR2## R' is hydrogen or C.sub.1 to C.sub.12 alkyl and R is an aliphatic, cycloaliphatic, or olefinic radical, or an acrylic polymer moiety having at least one group selected from hydroxyl, carboxyl, amido, and ureido, said reaction proceeding between a methylol or alkoxy alkyl group of (a) and the group selected from hydroxyl, carboxyl, amido and ureido of (b).
    Type: Grant
    Filed: September 26, 1983
    Date of Patent: September 29, 1987
    Assignee: PPG Industries, Inc.
    Inventors: Wen-Hsuan Chang, Michael M. Chau, Robert Piccirilli
  • Patent number: 4695600
    Abstract: These compounds are useful as light stabilizers in polymeric systems. ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are organic radicals.
    Type: Grant
    Filed: June 17, 1986
    Date of Patent: September 22, 1987
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4684644
    Abstract: The present invention is directed to a class of basic monocarboxyamide derivatives of actagardine. Actagardine (INN) is an antibiotic substance produced by actinoplanes strains such as Actinoplanes Sp. ATCC 31048 and Actinoplanes Sp. ATCC 31049 which are described in U.S. Pat. No. 4,022,884. Actagardine shows antimicrobial in vitro and in vivo activity against gram-positive organisms. Its complete chemical structure is not yet known but there is only information on its chemical functions and main fragments. In particular, it has been found that actagardine has two carboxylic functions and a primary amino function and can therefore be represented as follows: ##STR1## The compounds of the invention are monoamide derivatives at one of the carboxy functions of actagardine.
    Type: Grant
    Filed: March 21, 1986
    Date of Patent: August 4, 1987
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Bruno Cavalleri
  • Patent number: 4678787
    Abstract: Novel 4H-1-benzopyran-4-ones and their sulfur containing analogs are disclosed which are efficacious for the treatment of psychosis including schizophrenia.
    Type: Grant
    Filed: November 22, 1985
    Date of Patent: July 7, 1987
    Assignee: Warner-Lambert Company
    Inventors: Juan C. Jaen, Lawrence D. Wise
  • Patent number: 4668273
    Abstract: The invention relates to processes for the treatment of substrates which comprise applying at least one ammonium salt to the substrate as an algicide, bactericide or fungicide, said ammonium salt containing units which contain diepoxide and diamine radicals.
    Type: Grant
    Filed: September 24, 1982
    Date of Patent: May 26, 1987
    Assignee: Ciba-Geigy Corporation
    Inventor: Jaroslav Haase
  • Patent number: 4656180
    Abstract: Diamine derivatives corresponding to the general formula IR.sup.1 R.sup.2 N--(CH.sub.2).sub.m --Q--A--NH--R--NH--B--Q'--(CH.sub.2).sub.n NR.sup.3 R.sup.4 (I)which have a highly selective action on histamine-H.sub.2 receptors and are therefore suitable for use as anti-ulcerative agents are described. Processes for the preparation of these compounds and pharmaceutical preparations containing these compounds are also described.
    Type: Grant
    Filed: March 5, 1985
    Date of Patent: April 7, 1987
    Assignee: Ludwig Heumann & Co., GmbH
    Inventors: Stefan Postius, Rolf Herter, Peter Morsdorf, Helmut Schickaneder, Istvan Szelenyi, Kurt H. Ahrens
  • Patent number: 4632986
    Abstract: Thiocarbamylsulfenamides are readily recovered from solutions of the thiocarbamylsulfenamides by the addition of a dilute aqueous caustic solution, to flash off the solvent separating the thiocarbamylsulfenamide from the resulting water slurry and drying the thiocarbamylsulfenamide.
    Type: Grant
    Filed: July 29, 1985
    Date of Patent: December 30, 1986
    Assignee: The BFGoodrich Company
    Inventors: Enrique G. Reynes, John O. Leising
  • Patent number: 4609698
    Abstract: Oligomeric esters of the formula I or II ##STR1## in which n has a value from 1 to 3, R.sup.1 and R.sup.2 are divalent organic radicals, at least one of which contains a polyalkylpiperidine radical of the formula III ##STR2## in which R is hydrogen or C.sub.1 -C.sub.4 -alkyl and E and E' are end groups, are prepared by polycondensing a dicarboxylic acid ester with a diol, one of the two components being used in a molar excess of 33 to 100%. The end groups of these oligoesters can be modified by reaction with a monofunctional component. If two different dicarboxylic acid esters or diols are used, the corresponding co-oligoesters are obtained. All these oligoesters are valuable light stabilisers for light-sensitive organic material, especially for polymer.
    Type: Grant
    Filed: April 26, 1985
    Date of Patent: September 2, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Friedrich Karrer, Jean Rody
  • Patent number: 4600774
    Abstract: Cyclic sulfoperfluoroaliphaticcarboxylic acid anhydrides, amide derivatives thereof, a process for making the same, curable compositions containing cyclic sulfoperfluoroaliphaticcarboxylic acid anhydrides or amide derivatives thereof and cationically-sensitive monomers, and a process for using cyclic sulfoperfluoroaliphaticcarboxylic acid anhydrides or amide derivatives thereof as catalysts for the cure of cationically-sensitive monomers.
    Type: Grant
    Filed: June 13, 1985
    Date of Patent: July 15, 1986
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Robert J. Koshar
  • Patent number: 4593102
    Abstract: Novel pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds having the formula: ##STR1## wherein X is --S--, --S(O)-- or --S(O).sub.2 --; A is a loweralkalene chain and A.sup.1 and A.sup.2 are alkalene chains when p and d are one; R, R.sup.1 and R.sup.2 are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R.sup.1 and R.sup.2 may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts useful as cardiac antiarrhythmia agents are disclosed.Novel chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with --(A.sup.2).sub.p --X--(A.sup.2).sub.d --Q side chain are also disclosed.
    Type: Grant
    Filed: July 1, 1985
    Date of Patent: June 3, 1986
    Assignee: A. H. Robins Company, Inc.
    Inventor: James R. Shanklin, Jr.
  • Patent number: 4588734
    Abstract: Compounds of the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl,n is an integer from 0 to 4 inclusive,M is heterocyclic or heterocyclic alkyl,Y is hydroxy, alkoxy, amino, or substituted amino, amino-alkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is hydrogen, alkanoyl, carboxylalkanoyl, hydroxyalkanoyl, amino-alkanoyl, cyano, amidino, carbalkoxy, ZS, or ##STR2## wherein Z is hydrogen, alkyl, hydroxyalkyl, aminoalkyl or the radical ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n, M and Y are as described above; and where Y is hydroxy their nontoxic, pharmaceutically acceptable alkali metal, alkaline earth metal, and amine salts.These compounds possess antihypertensive and angiotensin converting enzyme inhibitory activity.
    Type: Grant
    Filed: November 19, 1984
    Date of Patent: May 13, 1986
    Assignee: USV Pharmaceutical Corp.
    Inventors: John T. Suh, Jerry W. Skiles, Bruce E. Williams, Alfred Schwab
  • Patent number: 4579863
    Abstract: Substituted trans-1,2-diaminocyclohexyl amide compounds demonstrating selective opioid receptor binding possess utility as analgesic, diuretic, and psychotherapeutic agents. A method of preparing the compounds, pharmaceutical compositions employing the compounds, and a method of alleviating pain employing the compounds are also disclosed.
    Type: Grant
    Filed: December 6, 1983
    Date of Patent: April 1, 1986
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Andrew Beeby
  • Patent number: 4578454
    Abstract: A novel class of polymeric compounds containing piperidine radicals of the formula ##STR1## in which X is a divalent radical selected from the group comprising ##STR2## is described. The novel compounds are light stabilizers, heat stabilizers and oxidation stabilizers for synthetic polymers and are particularly effective in polyolefine films, fibres and tapes.
    Type: Grant
    Filed: May 8, 1984
    Date of Patent: March 25, 1986
    Assignee: Ciba-Geigy S.p.A.
    Inventor: Giuseppe Cantatore
  • Patent number: 4562201
    Abstract: The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S-- where R.sub.1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y).sub.A is --CH.sub.2 NR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 may be hydrogen, substituted alkyls, aryls, or together with N form a 5 to 7 membered heterocyclic group; and Ar is a substituted or unsubstituted aryl. These compounds are useful in the treatment of various cardiac arrhythmias.
    Type: Grant
    Filed: July 26, 1982
    Date of Patent: December 31, 1985
    Assignee: American Hospital Supply Corporation
    Inventors: David M. Stout, William L. Matier
  • Patent number: 4556714
    Abstract: Compounds of the formula I ##STR1## in which m is zero, 1 or 2 and n is 2, 3 or 4, R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl, A is the n-valent radical of a polyol and R.sup.2 and R.sup.3 are monovalent radicals as defined in claim 1, are outstanding light stabilizers for organic materials, particularly for organic polymers.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: December 3, 1985
    Assignee: Ciba-Geigy Corporation
    Inventor: Friedrich Karrer
  • Patent number: 4546148
    Abstract: Novel polycondensed compounds containing piperidine groups of polycarbamate structure, of the general formula: ##STR1##
    Type: Grant
    Filed: July 19, 1984
    Date of Patent: October 8, 1985
    Assignee: Ciba-Geigy S.p.A.
    Inventor: Giuseppe Cantatore
  • Patent number: 4537924
    Abstract: Quadratic acid bisamides and salts thereof having the formula I are effective stabilizers of synthetic resins, especially for imparting resistance to deterioration resulting from exposure to light ##STR1## wherein R.sub.1 is H, C.sub.1-12 alkyl or OH-substituted C.sub.2-12 alkyl; R.sub.2 is --(CH.sub.2).sub.m --O--.sub.n, wherein m is an integer of 2-6; n is 0 or 1;R.sub.3 is H, CH.sub.3, CH.sub.2 --CH.sub.2 --OH, CH.sub.2 --COOH or CH.sub.2 --CH.sub.2 --COOH;HX is an acid equivalent of an unsubstituted or substituted monobasic, dibasic or polybasic organic acid of not more than 20 carbon atoms, or of sulfuric or phosphoric acid; and0.ltoreq.p.ltoreq.2.
    Type: Grant
    Filed: September 14, 1983
    Date of Patent: August 27, 1985
    Assignee: Chemische Werke Huels, AG
    Inventors: Konrad Rombusch, Gunther Maahs, Wolfgang Schafer