Ring Nitrogen In The Polycyclo Ring System Patents (Class 546/198)
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Publication number: 20030166652Abstract: The invention concerns compounds of formula (I), and their use in therapy, particularly in the modulation of CCR3 activity.Type: ApplicationFiled: November 20, 2002Publication date: September 4, 2003Inventors: Hitesh Sanganee, Brian Springthorpe
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Publication number: 20030166925Abstract: The present invention provides a novel compound having a superior acetylcholinesterase inhibitory action.Type: ApplicationFiled: November 25, 2002Publication date: September 4, 2003Inventors: Yoichi Iimura, Takashi Kosasa
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Publication number: 20030162970Abstract: The invention is directed to methods to inhibit p38-&agr; kinase using compounds of the formula 1Type: ApplicationFiled: May 28, 2002Publication date: August 28, 2003Inventors: Babu J. Mavunkel, Sarvajit Chakravarty, John J. Perumattam, Sundeep Dugar, Qing Lu, Xi Liang
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Publication number: 20030162792Abstract: The present invention relates to an indole derivative having the formula 1Type: ApplicationFiled: December 11, 2002Publication date: August 28, 2003Applicant: H. Lundbeck A/SInventors: Benny Bang-Andersen, Krestian Larsen, Jan Kehler
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Publication number: 20030162805Abstract: Compounds of the formula 1Type: ApplicationFiled: March 3, 2003Publication date: August 28, 2003Applicant: WyethInventors: Gary P. Stack, Hong Gao, Elizabeth S. Gildersleeve
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Patent number: 6610696Abstract: The present invention is directed to compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof, and methods of making, methods of using and pharmaceutical compositions having compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof: In Structural Formula I, n is 2, 3, or 4; V is O or S; W is O, S, or SO2; R1 is H, a C1-C4 alkyl, phenyl or trifluoromethyl; R2 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, a cycloalkyl, or together with the phenyl to which they are bound form naphthyl or 1,2,3,4-tetrahydronaphthyl; R3 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, or a cycloalkyl; R4 are each, independently, H, a C1-C4 alkyl, an aryl, or benzyl; R5 are each, independently, H, a substituted or unsubstituted aryl or a heteroaryl, provided that at least one R5 is a substituted or uType: GrantFiled: April 11, 2002Date of Patent: August 26, 2003Assignees: Eli Lilly and Company, Ligand Pharmaceuticals, Inc.Inventors: Dawn A. Brooks, Christopher J. Rito, Anthony J. Shuker, Samuel J. Dominianni, Alan M. Warshawsky, Lynn S. Gossett, Donald P. Matthews, David A. Hay, Robert J. Ardecky, Pierre-Yves Michellys, John S. Tyhonas
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Publication number: 20030153566Abstract: The present invention relates to compounds of the formula 1Type: ApplicationFiled: December 2, 2002Publication date: August 14, 2003Inventors: Alexander Flohr, Roland Jakob-Roetne, Roger David Norcross, Claus Riemer
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Publication number: 20030148387Abstract: This invention provides methods for the solution-phase synthesis of arylbenzoxazoles. The methods involve condensation of aminophenols with benzaldehydes to form a Schiff base. The Schiff base is then induced to undergo oxidative cyclization in the presence of DDQ. The resulting arylbenzoxazoles can be separated from the reduced DDQ byproduct by treatment of reaction mixture with a strongly basic ion exchange resin.Type: ApplicationFiled: November 19, 2002Publication date: August 7, 2003Applicant: IRM LLC, a Delaware LLCInventors: Junbiao Chang, Shifeng Pan
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Publication number: 20030144325Abstract: Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF&agr; in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafuoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.Type: ApplicationFiled: January 6, 2003Publication date: July 31, 2003Inventors: George W. Muller, David I. Stirling, Roger Shen-Chu Chen
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Publication number: 20030144520Abstract: The invention is directed to methods to inhibit p38-&agr; kinase using compounds of the formula 1Type: ApplicationFiled: May 28, 2002Publication date: July 31, 2003Inventors: Babu J. Mavunkel, Sarvajit Chakravarty, John J. Perumattam, Sundeep Dugar, Qing Lu, Xi Liang
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Publication number: 20030144288Abstract: The present invention relates to compounds of the formula 1Type: ApplicationFiled: December 2, 2002Publication date: July 31, 2003Inventors: Alexander Flohr, Roland Jakob-Roetne, Roger David Norcross, Claus Riemer
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Publication number: 20030139389Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof:Type: ApplicationFiled: December 11, 2002Publication date: July 24, 2003Applicant: SmithKline Beecham p.l.c.Inventors: Francis David King, Laramie Mary Gaster, Keith Raymond Mulholland
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Patent number: 6589956Abstract: A compound of formula (I): wherein: Ra represents a hydroxy, alkoxy, aryloxy or arylalkyloxy group, A represents a CH group or a nitrogen atom, in which case R1 is as defined in the description, or R1—A together represent an oxygen atom or a group, wherein R3 and R4 are as defined in the description, R2 being a hydrogen atom or an alkyl group, Rb and Rc, which may be identical or different, each represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, a hydroxy group or a trihaloalkyl group, n is an integer of from 2 to 6 inclusive, m and p are integers of from 0 to 6 inclusive, its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful as a TXA2 receptor antagonist and 5-HT2 receptor antagonist.Type: GrantFiled: July 12, 2002Date of Patent: July 8, 2003Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Christine Vayssettes-Courchay
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Patent number: 6586452Abstract: The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.Type: GrantFiled: July 9, 2001Date of Patent: July 1, 2003Assignee: Merck & Co., Inc.Inventors: Thomas Shih, Steven L. Colletti, Michael H. Fisher, Peter T. Meinke, Howard C. H. Kuo, Prasun K. Chakravarty, Matthew J. Wyvratt, Sriram Tyagarajan, Richard Berger
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Publication number: 20030119849Abstract: The invention relates to a group of novel piperazine and piperidine derivatives of the formula wherein Y is hydrogen, halogen, alkyl (1-3C), or CN, CF3, OCF3, SCF3, alkoxy(1-3C), amino or mono- or dialkyl(1-3C) substituted amino or hydroxy, X is O, S, SO or SO2, -Z represents —C, ═C or —N, R1 and R2 independently represent hydrogen or alkyl (1-3C), Q is benzyl or 2-, 3- or 4-pyridylmethyl, wich groups may be substited with one or more more substituents from the group halogen, nitro, cyano, amino, mono- or di (1-3C)alkylamino, (1-3C) alkoxy, CF3, OCF3, SCF3, (1-4C)-alkyl, (1-3C)alkylsulfonyl or hydroxy,and salts and prodrugs thereof. It has been found that these compounds have interesting pharmacological properties due to a combination of (partial) agonism towards the members of the dopamine D2-receptor subfamily and affinity for relevant serotonin and/or noradrenergic receptors.Type: ApplicationFiled: October 15, 2002Publication date: June 26, 2003Inventors: Roelof W. Feenstra, Johannes A.M. van der Heijden, Cornelis G. Kruse, Stephen K. Long, Gustaaf J.M. van Scharrenburg
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Publication number: 20030114448Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.Type: ApplicationFiled: May 28, 2002Publication date: June 19, 2003Applicant: Millennium Pharmaceuticals, Inc.Inventors: Penglie Zhang, Bing-Yan Zhu, Wenrong Huang, Robert M. Scarborough
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Patent number: 6579881Abstract: A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R1, R2, R3, R4, and R5 each represent a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3. The compounds have serotonin antagonism. They are therefore clinically useful as medicaments, in particular, for treating, ameliorating, and preventing spastic paralysis. They are also useful as central muscle relaxants for ameliorating myotonia.Type: GrantFiled: May 18, 2001Date of Patent: June 17, 2003Assignee: Eisai Co., Ltd.Inventors: Noritaka Kitazawa, Kohshi Ueno, Keiko Takahashi, Teiji Kimura, Atsushi Sasaki, Koki Kawano, Tadashi Okabe, Makoto Komatsu, Manabu Matsunaga, Atsuhiko Kubota
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Publication number: 20030109714Abstract: This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.Type: ApplicationFiled: September 20, 2002Publication date: June 12, 2003Inventors: Neil Wishart, Alena Rudolph, Kurt Ritter
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Patent number: 6576653Abstract: This invention relates to compounds of Formula I or stereoisomers, pharmaceutically acceptable salts or prodrugs thereof or a pharmaceutically acceptable salts of the prodrugs. This invention also relates to pharmaceutical compositions comprising a compound of Formula I, and to methods of treatment of diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis, or tissue ischemia.Type: GrantFiled: April 5, 2002Date of Patent: June 10, 2003Assignee: Pfizer Inc.Inventor: Daisy Joe Du Bois
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Publication number: 20030100545Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.Type: ApplicationFiled: September 30, 2002Publication date: May 29, 2003Inventors: Nicholas Michael Kelly, Kristian Norup Koch, Bo-Ragnar Tolf
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Patent number: 6569882Abstract: Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein the variables are as defined herein.Type: GrantFiled: February 19, 2002Date of Patent: May 27, 2003Assignee: G. D. Searle & Co.Inventors: John N. Freskos, Daniel P. Getman, John J. Talley, James A. Sikorski
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Publication number: 20030092717Abstract: The invention is directed to methods to inhibit p38-&agr; kinase using compounds of the formula 1Type: ApplicationFiled: November 20, 2001Publication date: May 15, 2003Inventors: Sundeep Dugar, John Perumattam, Gregory Luedtke, Xuefei Tan, Qing Lu
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Publication number: 20030083336Abstract: The present invention relates to a novel class of substituted phenylpiperazinyl derivatives having the formula 1Type: ApplicationFiled: June 25, 2002Publication date: May 1, 2003Applicant: H. Lundbeck A/SInventors: Thomas Ruhland, Jan Kehler, Kim Andersen, Benny Bang-Andersen, Mario Rottlander
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Heterocyclylalkoxy-,-alkylthio-and -alkylaminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
Publication number: 20030078286Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.Type: ApplicationFiled: April 19, 2002Publication date: April 24, 2003Applicant: WyethInventors: Yanfang Li, Ping Zhou -
Patent number: 6552199Abstract: The subject matter of the invention are new xanthene derivatives of the formula I, wherein R1,R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and X, Y, are as defined herein. The compounds according to the invention provide molecules that are—due to their spectral properties (absorption maxima in the range of approx. 650 nm and above as well as emission maxima above 670 nm)—very suitable for the use as dyes and in particular as fluorescence dyes. The compounds of the formula I according to the invention are used for the production of fluorescence conjugates, for their application in immunoassays, for DNA analytics, for in-vivo diagnostics or as a laser dye.Type: GrantFiled: May 11, 2000Date of Patent: April 22, 2003Assignee: Roche Diagnostics GmbHInventors: Ewald Daltrozzo, Alexander Reiss
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Patent number: 6552044Abstract: The present invention relates to substituted indane or dihydroindole compounds of Formula (I) wherein A is an indole. These compounds have high affinity for D4 receptors.Type: GrantFiled: March 21, 2001Date of Patent: April 22, 2003Assignee: H. Lundbeck A/SInventors: Jens Kristian Perregaard, Benny Bang-Andersen, Henrik Pedersen, Ivan Mikkelsen, Robert Dancer
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Publication number: 20030073697Abstract: Compounds of the formula 1Type: ApplicationFiled: April 25, 2002Publication date: April 17, 2003Applicant: WyethInventors: Megan Tran, Gary P. Stack
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Publication number: 20030073690Abstract: Novel compounds of the formula 1Type: ApplicationFiled: May 23, 2002Publication date: April 17, 2003Inventors: Deen Tulshian, Ginny D. Ho, Lisa S. Silverman, Julius J. Matasi, Robbie L. McLeod, John A. Hey, Richard W. Chapman, Ana Bercovici, Francis M. Cuss
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Patent number: 6548667Abstract: The present invention provides a novel sulfonamide derivative of general formula (I) useful as an inhibitor of matrix metalloproteinase (MMP), its isomers, pharmaceutically acceptable salts thereof and a process for preparing the same. Since the sulfonamide derivatives of the present invention selectively inhibit MMP activity in vitro, the MMP inhibitors comprising the sulfonamide derivatives as an effective ingredient can be practically applied for the prevention and treatment of all sorts of diseases caused by overexpression and overactivation of MMP.Type: GrantFiled: December 6, 2001Date of Patent: April 15, 2003Assignee: Samsung Electronics Co. Ltd.Inventors: Young-Jun Park, Hae-Young Bae, Ji-Uk Yoo, Myeong-Yun Chae, Sang-Hyun Paek, Hye-Kyung Min, Hyun-Gyu Park, Choon-Ho Ryu, Kyung-Chul Kim, Jeoung-Wook Lee
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Patent number: 6548516Abstract: Piperidine derivatives of the formula I and their physiologically acceptable salts in which X, Y, Z, R1, R2, R3 and R4 are as defined in claim 1 can be as excitatory amino acid antagonists for combating neurodegenerative disorders including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease and Huntington's disease, cerebral ischaemias, infarcts and psychosis.Type: GrantFiled: September 14, 2000Date of Patent: April 15, 2003Assignee: Merck Patent GmbHInventors: Helmut Prücher, Joachim Leibrock, Andrew Barber, Gerd Bartoszyk
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Publication number: 20030069249Abstract: A compound of the formula (I), (II), (III) or (IV) 1Type: ApplicationFiled: April 18, 2002Publication date: April 10, 2003Inventors: Qun Sun, R. Richard Goehring, Donald Kyle, Zhengming Chen, Sam Victory, John Whitehead
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Patent number: 6541471Abstract: A compound of formula (I): wherein: G represents a group such as: wherein R1 and R2 independently represent a hydrogen atom or an alkyl, cycloalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl or heteroarylalkyl group, or, R1 and R2 together with the nitrogen atom form a heterocycloalkyl group, R3 represents a hydrogen atom or an alkyl or optionally substituted phenyl group, Ra represents a hydroxy group, a linear or branched (C1-C6)alkoxy group or an amino group, Rb and Rc, which may be identical or different, each represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, a hydroxy group or a trihaloalkyl group, m is an integer of from 0 to 1 inclusive, n and q are integers of from 0 to 6 inclusive, p and r are integers of from 1 to 6 inclusive, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base; and medicinal products containing the same which are useful as a TXA2 receptType: GrantFiled: July 12, 2002Date of Patent: April 1, 2003Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Thierry Dubuffet, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Christine Vayssettes-Courchay
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Patent number: 6538002Abstract: The present in to s directed to compounds of the formula I: (wherein R1, R2, R3, R7, R8, X, Y, Z, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.Type: GrantFiled: June 8, 2000Date of Patent: March 25, 2003Assignee: Merck & Co., Inc.Inventors: Paul E. Finke, Malcolm Maccoss, Sander G. Mills, Bryan Oates
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Patent number: 6534650Abstract: This invention relates to compounds of Formula V H—Y—G—R V and Formula VI (wherein f, X, Y, G and R have the values defined in the description) which are useful as intermediates for the preparation of compounds, or pharmaceutically acceptable salts thereof, which are useful as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.Type: GrantFiled: March 9, 2001Date of Patent: March 18, 2003Assignee: Eli Lilly and CompanyInventors: Valentine J Klimkowski, Aaron L Schacht, Michael R Wiley
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Patent number: 6525075Abstract: Compounds of the formula: useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.Type: GrantFiled: April 25, 2002Date of Patent: February 25, 2003Assignee: WyethInventors: Megan Tran, Gary P. Stack
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Patent number: 6521758Abstract: Tosylate salts are useful in purifying 4-(fluorophenyl)-3-carbinol-piperidines from the corresponding des-fluoro impurity. The purified compounds are advantageously used in paroxetine synthesis.Type: GrantFiled: May 14, 2001Date of Patent: February 18, 2003Assignee: Synthon BVInventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Pavel Slanina
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Patent number: 6521754Abstract: The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.Type: GrantFiled: June 14, 2001Date of Patent: February 18, 2003Assignee: Hoffman-La Roche Inc.Inventors: Alexander Alanine, Alexander Flohr, Aubry Kern Miller, Roger David Norcross, Claus Riemer
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Publication number: 20030013730Abstract: This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect.Type: ApplicationFiled: August 16, 2002Publication date: January 16, 2003Applicant: MEIJI SEIKA KAISHA, LTD.Inventors: Yasuo Sato, Megumi Yamada, Kazuko Kobayashi, Katsuyoshi Iwamatsu, Fukio Konno, Koichi Shudo
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Patent number: 6500845Abstract: The invention relates to the use of certain lactam derivatives corresponding to the formula I as pharmaceutical compounds with immunomodulatory activity, to new lactam derivatives, and to processes for preparing these derivatives.Type: GrantFiled: June 6, 1995Date of Patent: December 31, 2002Assignee: Gruenenthal GmbHInventors: Horst Boehlke, Michael Finkam, Oswald Zimmer, Johannes Schneider, Stephan Wnendt, Kai Zwingenberger
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Patent number: 6500851Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.Type: GrantFiled: February 22, 2002Date of Patent: December 31, 2002Assignee: Eli Lilly and CompanyInventors: Douglas Wade Beight, Trelia Joyce Craft, Jeffry Bernard Franciskovich, Theodore Goodson, Jr., Steven Edward Hall, David Kent Herron, Valentine Joseph Klimkowski, Jeffrey Alan Kyle, John Joseph Masters, David Mendel, Guy Milot, Jason Scott Sawyer, Robert Theodore Shuman, Gerald Floyd Smith, Anne Louise Tebbe, Jennifer Marie Tinsley, Leonard Crayton Weir, James Howard Wikel, Michael Robert Wiley, Ying Kwong Yee
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Publication number: 20020198217Abstract: Compounds of the formula: 1Type: ApplicationFiled: April 24, 2002Publication date: December 26, 2002Applicant: WyethInventors: Megan Tran, Gary P. Stack
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Patent number: 6498170Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.Type: GrantFiled: July 12, 2001Date of Patent: December 24, 2002Assignee: WyethInventors: Fuk-Wah Sum, Baihua Hu
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Patent number: 6498161Abstract: The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.Type: GrantFiled: April 4, 2000Date of Patent: December 24, 2002Assignee: Merck & Co., Inc.Inventors: Charles G. Caldwell, Kevin T. Chapman, Jeffrey Hale, Dooseop Kim, Christopher Lynch, Malcolm MacCoss, Sander G. Mills, Christopher Willoughby, Scott Berk, Ronald M. Kim
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Publication number: 20020193365Abstract: Compounds of the formula 1Type: ApplicationFiled: April 25, 2002Publication date: December 19, 2002Applicant: WyethInventors: Gary P. Stack, Megan Tran
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Publication number: 20020169314Abstract: The present invention provides a novel sulfonamide derivative of general formula (I) useful as an inhibitor of matrix metalloproteinase (MMP), its isomers, pharmaceutically acceptable salts thereof and a process for preparing the same. Since the sulfonamide derivatives of the present invention selectively inhibit MMP activity in vitro, the MMP inhibitors comprising the sulfonamide derivatives as an effective ingredient can be practically applied for the prevention and treatment of all sorts of diseases caused by overexpression and overactivation of MMP.Type: ApplicationFiled: December 6, 2001Publication date: November 14, 2002Inventors: Young-Jun Park, Hae-Young Bae, Ji-Uk Yoo, Myeong-Yun Chae, Sang-Hyun Paek, Hye-Kyung Min, Hyun-Gyu Park, Choon-Ho Ryu, Kyung-Chul Kim, Jeoung-Wook Lee
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Patent number: 6476051Abstract: Compounds of Formula I: wherein Ar, Y, m, and Z are as defined in the specification, are useful antipsychotic and antidepressant agents demonstrating potent inhibition of 5-HT reuptake and dopamine D2 receptor antagonism.Type: GrantFiled: December 12, 2000Date of Patent: November 5, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Ronald J. Mattson, Joseph P. Yevich, Jun Yuan, Arlene S. Eison, Derek Denhart
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Patent number: 6472394Abstract: Disclosed are compounds represented by structural formula I: or a pharmaceutically acceptable salt, ester or solvate thereof, wherein W is R1—CR3R12NR4C(O)— or R11C(O)NR4—; the dotted line is an optional double bond; X is —CHR8—, —C(O)—, or —C(═NOR9)—; Y is R1 is optionally substituted cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkyl-alkyl; R2 is optionally substituted aryl or heteroaryl; R3 is alkyl, aryl or heteroaryl; R4 and R12 are H or alkyl; R8 is H, alkyl or alkoxyalkyl; R9 is H, alkyl or arylalkyl; R10 is H, alkyl or aryl; R11 is or, when R2 is R6-heteroaryl or R10 is not H, R11 can also be R5-phenylalkyl; n is 1-3 and m is 1-5; and R14 is 1-3 substituents selected from H, alkyl, halogen, —OH, alkoxy and CF3; and pharmaceutical compositions containing the compounds and methods of using the compounds in the trType: GrantFiled: December 17, 2001Date of Patent: October 29, 2002Assignee: Schering CorporationInventors: Brian A. McKittrick, Jing Su, John W. Clader, Shengjian Li, Guihau Guo
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Publication number: 20020156283Abstract: The present invention provides an arylpiperidine derivative of the formula (I) or a pharmaceutically acceptable salt thereof, which has antipsychotic effect: 1Type: ApplicationFiled: April 12, 2002Publication date: October 24, 2002Inventors: Masashi Nagamine, Makoto Gotoh, Masanori Yoshida, Atsuro Nakazato, Toshihito Kumagai, Shigeyuki Chaki, Kazuyuki Tomisawa
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Patent number: 6469011Abstract: Compound of formula (I): which is useful as a TXA2 and 5-HT2 receptor antagonist and pharmaceutical compositions containing the same.Type: GrantFiled: January 18, 2001Date of Patent: October 22, 2002Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Jean-Jacques Descombes
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Patent number: 6458785Abstract: Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.Type: GrantFiled: April 18, 2001Date of Patent: October 1, 2002Assignee: G. D. SearleInventors: Daniel P Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David L. Brown, Joseph J. McDonald