The Polycyclo Ring System Is Tricyclo-carbocyclic Patents (Class 546/203)
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Patent number: 4540519Abstract: This disclosure describes symmetrical 1,4-bis-(substituted-amino)-5,8-hydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.Type: GrantFiled: April 9, 1984Date of Patent: September 10, 1985Assignee: American Cyanamid CompanyInventors: Keith C. Murdock, Frederick E. Durr
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Patent number: 4528374Abstract: Novel oligomer or polymer polyamine-1,3,5-triazines containing at least one polyalkylpiperidine radical, for example that of the formula ##STR1## processes for their production, their use for stabilizing organic material, and the organic material protected therewith against oxidative and light-induced degradation.Type: GrantFiled: November 9, 1981Date of Patent: July 9, 1985Assignee: Ciba-Geigy CorporationInventor: Erwin Nikles
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Patent number: 4486598Abstract: Novel compounds of the following general formula: ##STR1##Type: GrantFiled: February 22, 1982Date of Patent: December 4, 1984Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4477668Abstract: (+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine, and its pharmaceutically acceptable salts is useful as an anxiolytic, antidepressant, anticonvulsant, muscle relaxant and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease. The racemate of the compound is produced by a four-step synthetic process in about 65% yield from 5H-dibenzo[a,d]cyclohepten-5-one.Type: GrantFiled: September 3, 1982Date of Patent: October 16, 1984Assignee: Merck & Co., Inc.Inventors: Dean R. Bender, Sandor Karady, Theresa Rothauser
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Patent number: 4461899Abstract: A series of ester and salt derivatives of fluorene-9-carboxylic acid and fluorene-1-carboxylic acid exhibit significant plant growth regulating properties, useful in controlling the size, shape, dormancy time, flowering time and/or fruit setting of plants, depending upon the concentrations used. They may also be used to control the growth rate, texture and color of turf grass. Presently preferred compounds include the cis-2,5-dimethylpyrrolidine salt of 1-fluorenecarboxylic acid, 9-cis-2,5-dimethyl-1-pyrrolidinyl-2-chlorofluorene-9-carboxylic acid, methyl ester, the 2,6-dimethylpiperidine salt of 1-fluorenecarboxylic acid, and the cis-2,5-dimethylpyrrolidine salt of 9-hydroxyfluorene-9-carboxylic acid.Type: GrantFiled: May 24, 1982Date of Patent: July 24, 1984Assignee: Diamond Shamrock Chemicals CompanyInventors: William J. Pyne, Han S. Ku, Robert E. Holm
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Patent number: 4459306Abstract: This invention relates to novel tricyclic ethers, pharmaceutically acceptable addition salts and optical isomers therefrom. The compounds described herein are useful as psychotropic agents in the treatment of depression and anxiety. Also included herein are methods of preparing said compounds, pharmaceutical compositions including them and methods of treating human or animal beings by administering these pharmaceutical compositions.Type: GrantFiled: April 6, 1981Date of Patent: July 10, 1984Assignee: Science Union et CieInventors: Charles Malen, Jean-Claude Poignant
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Patent number: 4452745Abstract: Fluorenes bearing a 9-aminoalkyl substituent are useful antiarrhythmic agents. Pharmaceutical formulations containing such compounds are provided, as well as a method of treatment.Type: GrantFiled: September 29, 1982Date of Patent: June 5, 1984Assignee: Eli Lilly and CompanyInventors: William B. Lacefield, Richard L. Simon
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Patent number: 4447368Abstract: Aromatic aminosulphonic acids which have a reduced content of discoloring by-products are obtained when aromatic amines are reacted with a sulphonating agent in a reaction medium at least some of which consists of tetramethylene sulphone.Type: GrantFiled: March 31, 1982Date of Patent: May 8, 1984Assignee: Siemens-Allis, Inc.Inventors: Herbert Emde, Heinz U. Blank, Peter Schnegg
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Patent number: 4447610Abstract: 10-Substituted 5-cyanomethylene-dibenzo[a,d]-cycloheptenes, their pure cis- and trans-isomers, their N-oxides and their pharmaceutically tolerated addition salts with acids, processes for their preparation, therapeutic agents containing these compounds and their use as drugs, especially as sedatives, hypnotics or tranquilizers.Type: GrantFiled: February 25, 1981Date of Patent: May 8, 1984Assignee: BASF AktiengesellschaftInventors: Gerd Steiner, Hans P. Hofmann, Horst Kreiskott, Hans-Juergen Teschendorf, Dieter Lenke
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Patent number: 4435336Abstract: Aminoarylsulphonic acids which have a relatively high purity and a relatively low content of aminoaryldisulphonic acids can be obtained, if they are prepared, from the corresponding arylammonium hydrogen sulphates, by an improved version of the so-called baking process, wherein the reaction is carried out under pressure at a temperature of at least 140.degree. C. and, at least partially, in the presence of water.Type: GrantFiled: March 31, 1982Date of Patent: March 6, 1984Assignee: Bayer AktiengesellschaftInventors: Herbert Emde, Heinz U. Blank, Peter Schnegg
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Patent number: 4426387Abstract: The invention concerns compounds of formula ##STR1## and acid addition and quaternary ammonium salts thereof, wherein the dotted line represents an optional bond, Ar represents a ring system of formula ##STR2## in which Q is O,S,--CR.sup.7 .dbd.CR.sup.8 --, --N.dbd.CR.sup.8 -- and --N.dbd.N--; R.sup.4, R.sup.5 and R.sup.6, and R.sup.7 and R.sup.8 when present, each represent hydrogen or defined substituents and additionally either R.sup.4 and R.sup.5 when adjacent or R.sup.6 and R.sup.8 when adjacent, together with the carbon atoms to which they are attached also represent a fused five or six membered carbocyclic or heterocyclic ring optionally carrying one or more defined substituents; R is an optionally substituted aryl or heteroaryl radical or a cycloalkyl radical containing 5 to 7 carbon atoms; R.sup.1, R.sup.2, R.sup.3 and R.sup.9 are each hydrogen or a lower alkyl group; n is 0 or 1; X is .dbd.O, .dbd.S or .dbd.NH; Y is --O-- or a direct bond and Z is --CO-- or --CH.sub.Type: GrantFiled: April 7, 1982Date of Patent: January 17, 1984Assignee: John Wyeth & Brother Ltd.Inventors: John L. Archibald, Terrence J. Ward
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Patent number: 4412999Abstract: Certain esters of cyproheptadine-3-carboxylic acid and its bioisosteres are peripherally selective dopamine antagonists useful in the treatment of emesis caused by stimulation of dopamine receptors of the chemoreceptor trigger zone, as well as emesis and nausea resulting from other causes including post operative emesis, chronic pediatric vomiting, radiotherapy and chemotherapy induced emesis, and nausea associated with migrane attacks and dysmenorrhea or arising idiopathically.They are also useful in the treatment of gastrointestinal disorders, such as gastro-oesophageal reflux caused by stimulation of dopamine receptors in the stomach or other causes and dyspepsia arising from delayed gastric emptying, post prandial dyspepsia or dyspepsia of unknown etiology.Type: GrantFiled: April 14, 1982Date of Patent: November 1, 1983Assignee: Merck & Co., Inc.Inventors: David C. Remy, Bradley V. Clineschmidt
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Patent number: 4379785Abstract: What are disclosed are sulfonyl ureas of the formula ##STR1## in which R.sup.1, X and Y are as defined in the specification, and their physiologically acceptable salts, pharmaceutical formulations on the basis of these compounds, and their use in the treatment of diabetes.Type: GrantFiled: December 17, 1980Date of Patent: April 12, 1983Assignee: Hoechst AktiengesellschaftInventors: Rudi Weyer, Volker Hitzel, Karl Geisen, Gunter Regitz
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Patent number: 4368205Abstract: Disclosed are novel compounds of the formula ##STR1## wherein R.sup.1 is a heterocyclic radical selected from furanyl, thienyl, pyridyl, pyrimidyl, oxazolyl, pyrrolyl, isoxazolyl, thiazolyl, and isothiazolyl, and R.sup.2 is hydrogen, a tetramethylcylopropanecarbonyl group, a 1-(substituted-phenyl)-2-methylpropyl-1-carbonyl group, a 1-(4-ethoxyphenyl)-2-dichlorocyclopropanecarbonyl group, or a substituted-vinyl-cyclopropanecarbonyl group. The compounds wherein R.sup.2 is other than hydrogen are insecticides.Type: GrantFiled: September 17, 1981Date of Patent: January 11, 1983Assignee: FMC CorporationInventor: John F. Engel
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Patent number: 4356184Abstract: 1-Piperidinylmethyl benzenamines represented by the formula: ##STR1## wherein X is S or --CH.sub.2 --CH.sub.2 --; R.sub.1 and R.sub.2 are the same different members of the group consisting of hydrogen or lower alkyl; and the pharmaceutically acceptable salts thereof. The compounds are useful as anti-allergic and antihypertensive agents.Type: GrantFiled: March 25, 1981Date of Patent: October 26, 1982Assignee: G. D. Searle & Co.Inventors: James R. Deason, Richard A. Partis
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Patent number: 4355036Abstract: Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3 or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ##STR4## is a nitrogen containing ring, ##STR5## must be phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is ##STR6## wherein p is 1 or 2 and n is 1 or 2, R.sup.1 is C.sub.1 to C.sub.6 alkyl, R.sup.2 is hydrogen or C.sub.1 to C.sub.6 alkyl, and the dotted line represents an optical double bond, R.sup.2 being absent if the double bond is present, and Y is substituted carboxylate or substituted sulfonyl. Said antihistamines have little or no sedative effects.Type: GrantFiled: March 16, 1981Date of Patent: October 19, 1982Assignee: Schering CorporationInventor: Frank J. Villani
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Patent number: 4349689Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: September 14, 1982Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4329469Abstract: An optically impure diastereomeric salt is purified by treating a suspension of the salt in an appropriate solvent or solvent mixture with the required amount of the desired, optically pure, acid or base.Type: GrantFiled: November 24, 1980Date of Patent: May 11, 1982Assignee: Merck & Co., Inc.Inventors: Torleif Utne, Ronald B. Jobson
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Patent number: 4328233Abstract: The invention relates to 2-hydroxymethyl-3,4,5-trihydroxy-6-substituted-piperidines and methods for their preparation. The invention also includes compositions containing said 2-hydroxymethyl-3,4,5-trihydroxy-6-substituted-piperidines and the use of said compounds and compositions for influencing carbohydrate metabolism and fat metabolism and for use in animal nutrition as feed additives.Type: GrantFiled: October 29, 1979Date of Patent: May 4, 1982Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Rudiger Sitt, Ernst Truscheit
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Patent number: 4315940Abstract: Sulfonylureas of the formula ##STR1## wherein n, R, R.sup.1 and X have the indicated meanings, as well as their physiologically acceptable salts, pharmaceutical preparations on the basis of these compounds and their use for treating diabetes.Type: GrantFiled: November 26, 1980Date of Patent: February 16, 1982Assignee: Hoechst AktiengesellschaftInventors: Volker Hitzel, Rudi Weyer, Karl Geisen, Gunter Regitz
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Patent number: 4310461Abstract: Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids are useful for the treatment of hypertension.Type: GrantFiled: June 23, 1980Date of Patent: January 12, 1982Assignee: E. R. Squibb & Sons, Inc.Inventors: John Krapcho, Peter C. Wade
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Patent number: 4306076Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: December 15, 1981Assignee: The Upjohn CompanyInventor: Norman A. Nelson
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Patent number: 4306075Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: December 15, 1981Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4277473Abstract: Compounds having the formula ##STR1## wherein a is 0 or 1, R.sub.1 is hydrogen or lower alkyl, A is lower alkylene or lower alkylidene, and R.sub.2 and R.sub.3, which can be the same or different, are hydrogen, lower alkyl, cycloalkyl, benzyl or substituted benzyl, or ##STR2## is a saturated heterocyclic ring, and acid addition salts thereof, possess anti-viral activity and reduced activity on the central nervous system.Type: GrantFiled: December 12, 1979Date of Patent: July 7, 1981Assignees: Kao Soap Co., Ltd., Sumitomo Chemical Industries Ltd.Inventors: Yoshiaki Inamoto, Motoyoshi Osugi, Eiji Kashihara
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Patent number: 4275070Abstract: The levorotatory enantiomers of 3-methoxy cyproheptadine and a related compound are antipsychotic agents.Type: GrantFiled: May 19, 1980Date of Patent: June 23, 1981Assignee: Merck & Co., Inc.Inventor: David C. Remy
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Patent number: 4258181Abstract: This disclosure describes anthracene-9,10-bis-carbonyl-hydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers.Type: GrantFiled: May 7, 1979Date of Patent: March 24, 1981Assignee: American Cyanamid CompanyInventors: Keith C. Murdock, Frederick E. Durr
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Patent number: 4254261Abstract: 6-Oxo-2-piperidinecarboxylic acid has been resolved via direct crystallization of pure S-6-oxo-2-piperidinecarboxylic acid dehydroabietylammonium salt from a solvent system consisting of dimethylformamide, cyclohexane and acetone. The S-enantiomer is a required component for making certain tripeptides related to thyrotropin releasing hormone (TRH) which are central nervous system stimulants.Type: GrantFiled: October 15, 1979Date of Patent: March 3, 1981Assignee: Merck & Co., Inc.Inventors: Stewart M. Miller, John L. Smith
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Patent number: 4254128Abstract: The invention provides novel 2-adamantyl hydrazine derivatives of the general formula A ##STR1## In this formula R.sub.1 is hydrogen or a lower alkyl group of 1-4 carbon atoms; R.sub.2 and R.sub.3 are the same or different and are each hydrogen, an unsubstituted or substituted radical being a lower alkyl of 1-4 carbon atoms, a lower alkanoic acid radical of 2-4 carbon atoms or a lower alkyl ester thereof, adamantyl, aryl, aralkyl, in which the alkyl moiety has from 1-4 carbon atoms or an unsubstituted or substituted heterocyclic radical of aromatic character; or R.sub.2 and R.sub.3 together with the nitrogen atom to which they are attached form an unsubstituted or substituted non-aromatic cyclic radical.The invention further provides pharmaceutically acceptable acid addition salts of the above compounds.Several methods of preparation of the new compounds are described.Type: GrantFiled: November 22, 1978Date of Patent: March 3, 1981Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Ben-Zion Weiner, Raul Suchi, Jeffrey Sterling, Haim Yellin
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Patent number: 4251655Abstract: Substituted N-iminomethylpiperidines are disclosed which are useful for the inhibition of gastric acid secretion.Type: GrantFiled: September 20, 1979Date of Patent: February 17, 1981Assignee: McNeilab, Inc.Inventors: Malcolm K. Scott, Chris R. Rasmussen
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Patent number: 4224344Abstract: Novel 9-aminoalkyl-methanoanthracenes of the formula: ##STR1## wherein A is C.sub.1 -C.sub.4 alkylene or C.sub.3 -C.sub.4 alkenylene and R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.3 -C.sub.6 cycloalkyl(C.sub.1 -C.sub.3)alkyl, ar(C.sub.1 -C.sub.3)alkyl or polyhalo(C.sub.2 -C.sub.4)alkyl or, when taken together with the adjacent nitrogen atom, they may form a 5 to 7-membered nitrogen-containing heterocyclic ring which may contain an additional hetero atom, and their non-toxic salts, which are useful as anti-anxiety, anti-depressant, major tranquilizer, anti-histamine and anti-allergy drugs and can be prepared through a novel key intermediate, i.e., 9-formyl-9,10-dihydro-9,10-methanoanthracene, by various methods.Type: GrantFiled: December 11, 1975Date of Patent: September 23, 1980Assignee: Sumitomo Chemical Company, LimitedInventors: Makoto Sunagawa, Hiromi Sato, Junki Katsube, Hisao Yamamoto
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Patent number: 4218472Abstract: New geminally disubstituted indenes are of general formula I ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or R.sup.1 and R.sup.2 together form a direct bond or an alkylene group --(CH.sub.2).sub.n --, in which n is an integer from 1 to 4, R.sup.3 is hydrogen, C.sub.1-3 -alkoxy or halogen, and each of R.sup.4 and R.sup.5 is hydrogen or C.sub.1-4 -lower alkyl, or R.sup.4 and R.sup.5 together form an alkylene group --(CH.sub.2).sub.m --, in which m is an integer from 3 to 6; and the corresponding amine oxides, quaternary ammonium compounds and salts with physiologically acceptable acids.The indenes find use in treating incontinence, as a mucous membrane decongestant, as a blood pressure reducing agent, as vasocostrictor or as an anti-reserpine agent.The indenes may be prepared by processes known per se involving(a) synthesing the side chain --CH(OH)CH.sub.2 NR.sup.4 R.sup.Type: GrantFiled: August 1, 1978Date of Patent: August 19, 1980Assignee: AB KabiInventors: Aake N. Joensson, Tomas G. Kempe, Lembit Mikiver, Bengt A. Sparf
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Patent number: 4212871Abstract: 3-Hydroxymethyl derivatives of cyproheptadine and related compounds are appetite stimulants and antihistaminic agents.Type: GrantFiled: March 2, 1979Date of Patent: July 15, 1980Assignee: Merck & Co., Inc.Inventor: John D. Prugh
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Patent number: 4188485Abstract: The invention encompasses 1-[10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methyl]-4-substituted piperidines and related compounds of the formula ##STR1## and the non-toxic pharmaceutically acceptable acid addition salts thereof; wherein R in each occurrence represents hydrogen, halogen, alkyl radical of 1 to 7 carbon atoms, or trifluoromethyl, alike or different; R.sup.1 is hydrogen or alkyl radical of 1 to 7 carbon atoms; Z is hydroxy or NR.sup.2 R.sup.3 group wherein R.sup.2 and R.sup.3 are each hydrogen or alkyl radical of 1 to 7 carbon atoms or R.sup.2 and R.sup.Type: GrantFiled: June 16, 1978Date of Patent: February 12, 1980Assignee: G. D. Searle & Co.Inventor: Michael J. Kukla
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Patent number: 4182865Abstract: 5-Membered 1,3-diazacarbocyclic derivatives of guanidine having hypoglycemic activity.Type: GrantFiled: September 18, 1978Date of Patent: January 8, 1980Assignee: McNeil Laboratories, Inc.Inventor: Chris R. Rasmussen
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Patent number: 4172949Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or methyl; R.sup.1 is hydrogen, C.sub.1 to C.sub.8 linear or branched alkyl or C.sub.1 to C.sub.8 linear or branched alkanoyl; X is oxygen or sulfur; R.sup.2 is selected from the group hydrogen, C.sub.1 to C.sub.18 linear or branched alkyl and the radicals --(CH.sub.2).sub.n --NR.sup.3 R.sup.4, --CH.sub.2 --CH(OH)--CH.sub.2 --OH or a ketal thereof formed from the aldehyde or ketone R.sup.5 R.sup.6 CO, wherein R.sup.3 and R.sup.4 are each independently C.sub.1 to C.sub.6 linear or branched alkyl or R.sup.3 and R.sup.4 taken together with the nitrogen atom of the first radical are attached to form a 5- or 6-membered heterocyclic ring, R.sup.5 and R.sup.6 are each independently hydrogen, C.sub.1 to C.sub.6 linear or branched alkyl, phenyl or benzyl or R.sup.5 and R.sup.Type: GrantFiled: June 28, 1978Date of Patent: October 30, 1979Assignee: Syntex (U.S.A.) Inc.Inventors: James P. Dunn, Peter H. Nelson, Karl G. Untch
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Patent number: 4167573Abstract: Valuable novel 3,5-dimethyl-piperidin-4-one compounds, substituted at the nitrogen by a long-chain radical, which have a good fungicidal action, and a process for combating fungi by means of these compounds.Type: GrantFiled: May 1, 1978Date of Patent: September 11, 1979Assignee: BASF AktiengesellschaftInventors: Walter Himmele, Karl-Heinz Koenig, Norbert Goetz, Ernst-Heinrich Pommer
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Patent number: 4160031Abstract: 10,11-Dihydro-3-carboxycyproheptadine is disclosed to have pharmaceutical utility as an appetite stimulant and as an antihistaminic agent. Also disclosed are processes for the preparation of such compound; pharmaceutical compositions comprising such compound; and methods of treatment comprising administering such compound and compositions.Type: GrantFiled: November 22, 1976Date of Patent: July 3, 1979Assignee: Merck & Co., Inc.Inventor: David C. Remy
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Patent number: 4138419Abstract: A novel cyclopentadiene derivative of the general formula: ##STR1## wherein R.sup.1 is hydrogen, a mono- to tetra-hydric alcohol moiety having 1 to 12 carbon atoms, a metal of Groups Ia, IIa and IIb of the Periodic Table, an ammonium group or an organic amine residue; R.sup.2, R.sup.3, and R.sup.4 are independently hydrogen or alkyl groups having 1 to 6 carbon atoms; R.sup.a, R.sup.b, and R.sup.c are independently hydrogen or alkyl groups having 1 to 3 carbon atoms; m is 0 or 1; and n is an integer of 1 to 4. This cyclopentadiene derivative is comparable or even superior to natural rosin in effectiveness as an emulsifier for use in the production of SBR and ABS resins or as a sizing agent in paper making.Type: GrantFiled: April 29, 1977Date of Patent: February 6, 1979Assignee: Japan Synthetic Rubber Co., Ltd.Inventors: Masatoshi Arakawa, Ryotaro Ohno, Katuhiro Ishikawa, Noboru Yamahara, Hisashi Matsui
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Patent number: 4130710Abstract: New piperidine derivatives and in particular esters and amides of substituted (piperidinylidene-4) acetic acid are used as stabilizers for polymers, especially for polyolefines.Type: GrantFiled: April 23, 1976Date of Patent: December 19, 1978Assignee: Ciba-Geigy CorporationInventor: Barry Cook
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Patent number: 4128554Abstract: Carboxylic acid amides are obtained from aryl, heterocyclic, and vinylic halides and substituted derivates thereof, by reacting same with a primary or secondary amine and carbon monoxide, in the presence of a palladium catalyst and if necessry a tertiary amine at about 20.degree.-150.degree. C and from at least a half atmosphere pressure.Type: GrantFiled: March 10, 1977Date of Patent: December 5, 1978Assignee: University of DelawareInventor: Richard F. Heck
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Patent number: 4127717Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein n is 1 or 2; m is 2, 3 or 4; R.sub.1 is alkanoyl; and R.sub.2 is a tertiary amino group; have hypotensive activity.Type: GrantFiled: March 20, 1978Date of Patent: November 28, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Joyce Reid
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Patent number: 4125604Abstract: N.sup.2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.Type: GrantFiled: June 7, 1977Date of Patent: November 14, 1978Assignees: Mitsubishi Chemical Industries Limited, Shosuke OkamotoInventors: Shosuke Okamoto, Akiko Hijikata, Ryoji Kikumoto, Yoshikuni Tamao, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura