Abstract: Disclosed herein are compounds of the formula ##STR1## in which Ar is l-naphthyl; R.sup.1 and R.sup.2 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidine, morpholine and 4-(lower alkyl)-1-piperazinyl; and R.sup.3 and R.sup.4 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R.sup.3 and R.sup.4 together with the nitrogen to which they are joined represent a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl; or a therapeutically acceptable acid addition salt thereof. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
Type:
Grant
Filed:
May 19, 1976
Date of Patent:
February 20, 1979
Assignee:
Ayerst, McKenna and Harrison Limited
Inventors:
Jean-Marie Ferland, Real R. Laliberte, Wilbur Lippmann, Thomas A. Pugsley
Abstract: This invention relates to 3-(phenyl/naphthyl)benz[d]isothiazole-1,1-dioxides wherein the phenyl or naphthyl substituent possesses an N-heterocyclic moiety in the para position. These compounds are useful as intermediates in the synthesis of certain 3,3-disubstituted-2,3-dihydrobenz[d]isothiazole-1,1-dioxide dyes which find utility as, for example, photographic optical filter agents and filter agent precursors.
Type:
Grant
Filed:
September 23, 1977
Date of Patent:
February 13, 1979
Assignee:
Polaroid Corporation
Inventors:
Alan L. Borror, James W. Foley, John W. Lee, Jr.
Abstract: This invention relates to certain derivatives of phenylalanine having interesting pharmaceutical properties, in particular, a lipid-lowering activity.
Abstract: Novel 3-amino-2-OR-propoxyaryl substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.
Abstract: N.sup.2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.
Type:
Grant
Filed:
June 7, 1977
Date of Patent:
December 26, 1978
Assignees:
Mitsubishi Chemical Industries, Limited, Shosuke Okamoto
Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein n is 0, 1 or 2; R.sub.1 is alkanoyl; and R.sub.2 is ##STR2## R.sub.3 is alkyl; R.sub.4 is cyano or hydroxy; R.sub.5 is hydroxy or alkanoyloxy; R.sub.6 is hydrogen or alkanoyl; and m is 2, 3 or 4; have useful hypotensive properties.
Type:
Grant
Filed:
November 25, 1977
Date of Patent:
November 28, 1978
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Frederic P. Hauck, Rita T. Fox, John R. Watrous
Abstract: N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.
Type:
Grant
Filed:
January 19, 1977
Date of Patent:
November 14, 1978
Assignees:
Mitsubishi Chemical Industries, Ltd., Shosuke Okamoto
Abstract: N.sup.2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.
Type:
Grant
Filed:
June 7, 1977
Date of Patent:
November 14, 1978
Assignees:
Mitsubishi Chemical Industries Limited, Shosuke Okamoto