Phosphorus Attached Indirectly To The Six-membered Hetero Ring By Nonionic Bonding Patents (Class 546/22)
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Publication number: 20090036409Abstract: The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.Type: ApplicationFiled: August 20, 2008Publication date: February 5, 2009Inventors: Michael J. Hawkins, Michael N. Greco, Eugene Powell, Lawrence De Garavilla, Bruce E. Maryanoff
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Publication number: 20090036357Abstract: This invention relates to novel compounds that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering HIV protease inhibitors. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving atazanavir.Type: ApplicationFiled: June 12, 2008Publication date: February 5, 2009Applicant: CoNCERT Pharmaceuticals, Inc.Inventors: Scott L. Harbeson, Roger D. Tung
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Patent number: 7485726Abstract: The present invention relates to an improved process for the selective crystallization of 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium in pure hemi-pentahydrate form of Formula (I), by first converting 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid into organic amine salt and then by replacing it with sodium salt.Type: GrantFiled: January 16, 2007Date of Patent: February 3, 2009Assignee: Aurobindo Pharma Ltd.Inventors: Srinivasa Rao V. N Divvela, Lenin Racha, Sivakumaran Meenakshisunderam, Ramesh Dandala
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Patent number: 7476738Abstract: The present invention provides a method for confirming existence of a phosphoric acid monoester compound (peptide, saccharine and the like) and easily identifying the molecular weight thereof even among biological samples including a plurality of compounds, and an additive for a mass spectrometry used for the method. In the method according to the present invention, a complex compound exhibiting extremely high coordination ability to a phosphoric acid monoester group and configured of single kind of zinc isotopes is used to obtain a plurality of mass spectrum data, and then the data are compared.Type: GrantFiled: December 24, 2003Date of Patent: January 13, 2009Assignee: NARD Institute Ltd.Inventors: Tohru Koike, Norio Minami, Akihiko Kawasaki
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Publication number: 20080318905Abstract: Prodrugs of parent drugs and methods of making and using the same are described. The prodrugs comprise an amine-containing parent drug moiety and a prodrug moiety, such as methoxyphosphonic acid or ethoxyphosphonic acid. The prodrugs may be employed in therapy for the treatment of various indications, such as pain, and in methods of decreasing the abuse potential of abuse-prone drugs and/or delaying the onset of parent drug activity and/or prolonging parent drug activity as compared to administration of a parent drug.Type: ApplicationFiled: December 5, 2007Publication date: December 25, 2008Inventors: Naweed Muhammad, Keith R. Bley
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Publication number: 20080318906Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.Type: ApplicationFiled: April 15, 2008Publication date: December 25, 2008Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: John M. Sanders, Yongcheng Song, Julian M. W. Chan, Eric Oldfield, Yonghui Zhang
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Publication number: 20080318907Abstract: Nitroxide free radicals attached to antineoplastic agents can synergize their potencies to cancer cells. This invention relates to any antineoplastic agents and their derivatives chemically attached with nitroxide free radicals, such as TEMPO and its radical derivatives. This invention also relates to precursors of such compounds, as well as the products formed from the adducts after administration.Type: ApplicationFiled: March 12, 2007Publication date: December 25, 2008Applicant: The Trustees of California State UniversityInventors: Yong Ba, Errol V. Mathias
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Patent number: 7468359Abstract: The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of formula (I), some are known and others are new. The novel compounds constitute another aspect of the invention.Type: GrantFiled: May 23, 2006Date of Patent: December 23, 2008Assignee: Yissum Research Develpment Company of the Hebrew University of JerusalemInventors: Eli Breuer, Reuven Reich, Claudio Salomon
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Publication number: 20080312440Abstract: The present invention relates to drug derivatives and linkers. The invention specifically relates to compounds and methods of phosphonates and linkers, that are useful as carriers for imaging agents and useful in the treatment of various bone diseases.Type: ApplicationFiled: April 16, 2008Publication date: December 18, 2008Applicant: University of Southern CaliforniaInventors: Charles E. McKenna, Boris A. Kashemirov, Joy Lynn F. Bala
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Publication number: 20080300408Abstract: This process in general relates to the novel process for preparing polymorphic forms of 3-pyridyl-1-hydroxyethylidine-1,1-bisphosphonic acid sodium salt (Risedronate Sodium) in particular risedronate Form A and B employing a solvent system in an appropriate ratio. An improved process for preparation of risedronic acid is also disclosed in the present invention.Type: ApplicationFiled: August 21, 2006Publication date: December 4, 2008Applicant: JUBILANT ORGANOSYS LIMITEDInventors: Satish Chandra Pandey, Khushi Ram, Manoj Kumar Singh, Rajesh Kumar Thaper, Sushil Kumar Dubey
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Patent number: 7459461Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.Type: GrantFiled: April 16, 2003Date of Patent: December 2, 2008Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Michael N. Greco, Harold R. Almond, Lawrence de Garavilla, Michael J. Hawkins, Michael J. Humora, Yun Qian, Donald Gilmore Walker, Sergio Cesco-Cancian, Christopher Norman Nilsen, Mitul N. Patel, Kirk Leonard Sorgi, Eugene Powell
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Publication number: 20080287399Abstract: This invention relates to novel compounds having the structural formula (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.Type: ApplicationFiled: December 12, 2005Publication date: November 20, 2008Applicant: AstraZeneca ABInventors: Jeffrey Scott Albert, Owen Callaghan, James Campbell, Robin Arthur Ellis Carr, Gianni Chessari, Suzanna Cowan, Miles Stuart Congreve, Phil Edwards, Martyn Frederickson, Christopher William Murray, Sahil Patel
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Publication number: 20080287398Abstract: The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.Type: ApplicationFiled: May 2, 2008Publication date: November 20, 2008Inventors: Raymond W. Colburn, Scott L. Dax, Christopher Flores, Jay Matthews
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Publication number: 20080281104Abstract: A membrane anchoring-type fluorescent probe consisting of a compound comprising a phospholipid residue, a fluorescent probe compound residue, and a linker which binds the residues (e.g., the compound represented by the following formula).Type: ApplicationFiled: March 3, 2006Publication date: November 13, 2008Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Hirotatsu Kojima, Takashi Osaki
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Patent number: 7449571Abstract: Novel synthetic monomers that have the capacity to be assembled into defined oligomers which bind with sequence specificity to duplex Watson-Crick DNA via a triple helix motif are provided.Type: GrantFiled: June 14, 2005Date of Patent: November 11, 2008Assignee: Board of Regents of the University of NebraskaInventor: Barry I. Gold
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Patent number: 7442689Abstract: The present invention provides for pyridoxine phosphonate analogues, pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases.Type: GrantFiled: December 9, 2003Date of Patent: October 28, 2008Assignee: Medicure International Inc.Inventor: Wasimul Haque
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Publication number: 20080261923Abstract: Ac-Phe-Tyr-phosphoSer-?[CH?C]-Pro-Arg-NH2AND Fmoc-bis(pivaloylmethoxy)phosphoSer-?[CH?C]-Pro-2-aminoethyl-(3-indole); and their Phospho-(D)-serine stereoisomers are novel compounds. ? refers to a pseudo amide. Such novel compounds advantageously may be used as alkene mimics.Type: ApplicationFiled: July 29, 2005Publication date: October 23, 2008Inventors: Felicia A. Etzkorn, Xiaodong X. Wang, Bulling Xu
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Patent number: 7439385Abstract: The present invention provides a novel process for preparation of bisphosphonic acid derivatives or pharmaceutical acceptable salt thereof, by reacting carboxylic acid having structural formula (II) with phosphorous acid and a halophosphorous compound, wherein halophosphorous compound is selected from the group comprising of PCl3, PCl5, POCl3, PBr3, POBr3, and PBr5 in presence of diphenyl ether.Type: GrantFiled: July 24, 2006Date of Patent: October 21, 2008Assignee: Alembic LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra
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Publication number: 20080255070Abstract: The disclosure provides, inter alia, novel bisphosphonate compounds and methods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively inhibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selectively inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compounds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts, which in several cases exceed the activity levels of previous generation bisphosphonate drugs by orders of magnitude. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g.Type: ApplicationFiled: April 11, 2008Publication date: October 16, 2008Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Eric OLDFIELD, Yonghui ZHANG
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Patent number: 7432276Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.Type: GrantFiled: December 27, 2006Date of Patent: October 7, 2008Assignee: CV Therapeutics, Inc.Inventors: Matthew Abelman, Robert Jiang, Jeff Zablocki, Dmitry Koltun, Melanie Boze
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Publication number: 20080227683Abstract: Disclosed is the use of compounds of formula (I) wherein X, Y and Z are as defined in the description of the invention, for the preparation of an antitumor medicament, optionally in combination with different biologically active substances.Type: ApplicationFiled: February 8, 2005Publication date: September 18, 2008Applicant: DEFIANTE FARMACEUTICA LDAInventors: Gianfranco Peluso, Menotti Calvani
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Patent number: 7423045Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.Type: GrantFiled: June 28, 2006Date of Patent: September 9, 2008Assignee: CV Therapeutics, Inc.Inventors: Matthew Abelman, Robert Jiang, Jeff Zablocki, Dmitry Koltun
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Publication number: 20080207942Abstract: Phosphoramidites with the general formulae I to VI are claimed together with the use of these compounds as ligands of transition metal compounds, in particular in transition metal catalysts, in the hydrogenation, transfer hydrogenation, hydroboration, hydrocyanation, 1,4-addition, hydroformylation, hydrosilylation, hydrovinylation, and Heck reactions of prochiral olefins, ketones, or ketimines.Type: ApplicationFiled: September 12, 2006Publication date: August 28, 2008Applicant: Kaiser-Wilhelm-Platz 1Inventors: Manfred T. Reetz, Gerlinde Mehler
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Publication number: 20080200679Abstract: The present invention relates to a method for preparing ?-hydroxy, ?-substituted methylenebisphosphonates and phosphonoacetates via addition of Grignard or organoindium reagents to tetraalkyl carbonylbisphosphonates and trialkyl carbonylphosphonoacetates. Also disclosed are compounds so synthesized.Type: ApplicationFiled: January 22, 2008Publication date: August 21, 2008Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Charles E. McKenna, Boris A. Kashemirov, Gregorio V. Sanchez
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Publication number: 20080199454Abstract: The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. This invention further relates to pharmaceutical compositions comprising these compounds, which are particularly well-suited for treatment of caspase-mediated diseases, including inflammatory and degenerative diseases. This invention further relates to methods for preparing compounds of this invention.Type: ApplicationFiled: December 21, 2007Publication date: August 21, 2008Inventors: Michael Mortimore, Julian M.C. Golec
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Publication number: 20080194524Abstract: The present invention is related to compounds having formula (I) wherein the dashed line indicates a single or double bond or is absent and wherein A1-A9, Q, R1-R11, T, U, V, W1-W3, X1, X2, Y and Z are as defined in the claims and description, pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament for the treatment of diseases involving abnormal cell proliferation, undesired cell proliferation, abnormal mitosis and/or undesired mitosis.Type: ApplicationFiled: December 18, 2004Publication date: August 14, 2008Applicant: JERINI AGInventors: Jochen Knolle, Mike Schutkowski, Gerd Hummel, Thomas Tradler, Laurence Jobron, Claudia Christner, Christoph Gibson, Gunther Zischinsky
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Patent number: 7410956Abstract: The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. This invention further relates to pharmaceutical compositions comprising these compounds, which are particularly well-suited for treatment of caspase-mediated diseases, including inflammatory and degenerative diseases. This invention further relates to methods for preparing compounds of this invention.Type: GrantFiled: February 11, 2003Date of Patent: August 12, 2008Assignee: Vertex Pharmaceuticals IncorporatedInventors: Michael Mortimore, Julian M. C. Golec
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Patent number: 7411087Abstract: The present invention provides a novel process for preparation of bisphosphonic acids or salts thereof, e.g. alendronic acid, by reacting a carboxylic acid, phosphorous acid and a halophosphorous compound in a water miscible neutral solvent.Type: GrantFiled: August 10, 2004Date of Patent: August 12, 2008Assignee: Sun Pharmaceutical Industries LimitedInventors: Vijaykumar Muljibhai Patel, Trinadha Rao Chitturi, Rajamannar Thennati
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Publication number: 20080188443Abstract: The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.Type: ApplicationFiled: January 31, 2008Publication date: August 7, 2008Applicant: Pfizer, Inc.Inventors: Hengmiao (Henry) Cheng, Rajesh Devraj, Gary A. DeCresenzo, Xiao Hu, Kevin D. Jerome, Mark Obukowicz, Lisa Olson, Paul V. Rucker, Ronald Keith Webber
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Patent number: 7385058Abstract: Methods and compounds are provided for the formation of carbon-nitrogen or carbon-carbon bonds comprising reacting an amine or an aryl boronic acid with an aryl halide in the presence of a palladium catalyst, a base, and a compound of formula II:Type: GrantFiled: September 27, 2005Date of Patent: June 10, 2008Assignee: Iowa State University Research Foundation, Inc.Inventors: John G. Verkade, Sameer Urgaonkar, JuHua Xu
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Publication number: 20080125397Abstract: 2-({2-Oxo-2-[(pyridin-3-ylmethyl)amino]ethyl}sulfonyl)ethyl N,N,N?,N?-tetrakis(2-chloroethyl)phosphorodiamidate and its acid addition salts, especially in solid form, their preparation and intermediates in their preparation, formulations containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.Type: ApplicationFiled: November 28, 2006Publication date: May 29, 2008Inventors: Stella K. Lui, Wenli Ma, Robert M. Yee
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Publication number: 20080125398Abstract: 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N,N?,N?-tetrakis(2-chloroethyl)-phosphorodiamidates, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.Type: ApplicationFiled: November 29, 2006Publication date: May 29, 2008Inventors: Wenli Ma, Kevin T. Weber, Robert M. Yee
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Publication number: 20080119441Abstract: This invention related to a series of new phosphonic acid derivatives having anti-hyperphosphatemia activity. (I) [wherein: A is selected from —(CH2)n—, —CO—, —(CH2)n—CO—(CH2)m—, —(CH2)n—CS—(CH2)m— or branched alkylene group. B ring and C ring are selected from benzene ring, naphthalene ring, azulene ring or, heterocycle or fused heterocycle. D is —(CH2)(n+1)—, —(CH2)-O—(CH2)m—, —(CH2)—S(O)o—(CH2)m—, —CF3 or —(CH2)n—NR10—(CH2)m— (wherein: D ring is connected with the carbon atom composing C ring.) E is selected from oxygen atom or sulfur atom. P is phosphine atom. R1˜R7 (wherein R1 and R2, R4 and R5 are joined together with neighbored carbon atom to form 5˜7 membered saturated or unsaturated hydrocarbon ring, or 5˜6 membered fused heterocycle. R1, R2 and R3 are not hydrogen atom if B ring is benzene ring.) may be the same or different and are substituents. R8 and R9 are may be the same or different and are substituents. R10 is alkyl group. n and m are 0-10. o is 0-2.Type: ApplicationFiled: October 5, 2005Publication date: May 22, 2008Inventors: Hiroshi Tomiyama, Masayuki Yokota, Kazuo Tokuzaki, Ryoko Tomita
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Patent number: 7371739Abstract: Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.Type: GrantFiled: January 25, 2005Date of Patent: May 13, 2008Assignee: Metabasis Therapeutics, Inc.Inventors: Brett C. Bookser, Qun Dang, K. Raja Reddy
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Patent number: 7361761Abstract: The present invention is to relate an improved process using anisole as solvent for the preparation of compound of formula (I) and its pharmaceutically acceptable salts thereof. wherein R represents —NR1R2, or a group n=1, 2, 3, 4 and 5, where R1 and R2 may be same or different and independently represents hydrogen, or C1-6 alkyl.Type: GrantFiled: September 19, 2006Date of Patent: April 22, 2008Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Udayampalayam P. Senthilkumar, Thangavel Arulmoli, Venu S. Lakshmipathi, Siripragada M. Rao
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Patent number: 7358361Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.Type: GrantFiled: October 7, 2005Date of Patent: April 15, 2008Assignee: The Board of Trustees of the University of IllinoisInventors: John M. Sanders, Yongcheng Song, Julian M. W. Chan, Eric Oldfield, Yonghui Zhang
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Patent number: 7358360Abstract: The present invention relates to a method of making risedronate sodium substantially free of iron including the steps of refluxing, especially with mechanical agitation, a combination of risedronic acid, a sodium base, especially sodium hydroxide, and an iron-reducing amount of EDTA in a liquid that is water, a lower alkanol, or, especially, a mixture of a lower alkanol and water; and isolating risedronate sodium substantially free of iron from the combination.Type: GrantFiled: January 16, 2004Date of Patent: April 15, 2008Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Revital Lifshitz-Liron, Ramiy Lidor-Hadas, Nissm Sasson, Igor Lifshitz
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Patent number: 7345082Abstract: The present invention relates to phosphinic acid derivatives of formula I wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prevention of a disease related to the inhibition of ?-secretase, inter alia for the treatment of Alzheimer's disease.Type: GrantFiled: November 8, 2004Date of Patent: March 18, 2008Assignee: Hoffmann-La Roche Inc.Inventors: Hans Hilpert, Roland Humm, Dietmar Knopp, Peter Weiss
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Publication number: 20080051327Abstract: The present invention relates to crystals of phosphorylated Aurora-A kinase fragment alone and in complex with a ligand, amino acid residues 1-43 of human TPX2. This invention also relates to methods for designing and selecting ligands, in particular allosteric inhibitors of Aurora-A, that bind to the Aurora-A kinase and their use. Further, the present invention relates to certain indene and indole derivatives. The present invention relates to crystals of phosphorylated Aurora-A kinase alone and in complex with a ligand, amino acid residues 1-43 of human TPX2. This invention also relates to methods for designing and selecting ligands that bind to the Aurora-A kinase and their use. Further, the present invention relates to certain indene and indole derivative.Type: ApplicationFiled: October 11, 2004Publication date: February 28, 2008Applicant: EMBLInventors: Elena Conti, Richard Bayliss, Carsten Schultz, Isabelle Vernos, Teresa Sardon
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Patent number: 7332603Abstract: A process for preparing alendronate sodium includes the reaction of gammabutyric acid with phosphorous acid and phosphorus trichioride and subsequent treatment with an aqueous solution of an alkali metal hydroxide, in which the reaction is conducted in liquid ionic solvents.Type: GrantFiled: November 25, 2002Date of Patent: February 19, 2008Assignee: Chemi S.p.A.Inventors: Lorenzo De Ferra, Stefano Turchetta, Pietro Massardo, Paolo Casellato
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Publication number: 20080033176Abstract: A method for preparing a prostaglandin derivative represented by the following general formula (I): (wherein Ph represents phenyl group, R1 represents a C1-7 alkyl group, a C1-7 alkenyl group, phenyl group, or benzyl group), which comprises the successive steps (1) to (8) described in the specification, or any one step or two or more successive steps selected from the group consisting of the steps (1) to (8). A method for efficiently, inexpensively and safely preparing prostaglandin derivatives, of which typical example is latanoprost, is provided.Type: ApplicationFiled: March 20, 2007Publication date: February 7, 2008Applicant: DAIICHI FINE CHEMICAL CO., LTD.Inventors: Noriaki MURATA, Atsunori ARAMATA
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Patent number: 7320993Abstract: The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.Type: GrantFiled: June 16, 2000Date of Patent: January 22, 2008Assignee: Astellas Deutschland GmbHInventors: Elfi Biedermann, Max Hasmann, Roland Löser, Benno Rattel, Friedemann Reiter, Barbara Schein, Klaus Seibel, Klaus Vogt, Katja Wosikowski, Isabel Schemainda
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Publication number: 20080009465Abstract: Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n-Z-(CH2)m—PO(OR7)(OR8), —(CH2)nZ-(CH2)m—PO(OR7)Rg, —(CH2)n-Z-(CH2)m—OPO(OR7)Rg, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.Type: ApplicationFiled: June 28, 2007Publication date: January 10, 2008Inventors: Denis E. Ryono, Peter T.W. Cheng, Scott A. Bolton, Sean Chen, Yan Shi, Wei Meng, Joseph A. Tino, Hao Zhang, Richard B. Sulsky
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Patent number: 7317104Abstract: Chelants and macrocyclic metal complexes thereof, methods of preparing the chelants and macrocyclic metal complexes, and radiopharmaceutical compositions comprising the macrocyclic metal complexes are disclosed. Methods of using the macrocyclic metal complexes as radiopharmaceuticals for the diagnosis of cardiovascular disorders, infectious diseases and cancer are also disclosed. Chelants as bifunctional chelators (BFCs) for the radiolabeling of target-specific biomolecules, such as proteins, peptides, peptidomimetics, non-peptide receptor ligands, enzyme inhibitors, and enzyme substrates are disclosed. Methods of using macrocyclic metal complexes containing the chelant-biomolecule conjugates as target-specific diagnostic radiopharmaceuticals that selectively localize at sites of disease and allow an image to be obtained of the loci using gamma scintigraphy are disclosed.Type: GrantFiled: June 9, 2004Date of Patent: January 8, 2008Assignee: Bristol-Myers Squibb Pharma CompanyInventor: Shuang Liu
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Patent number: 7312219Abstract: Novel FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.Type: GrantFiled: August 6, 2003Date of Patent: December 25, 2007Assignee: Metabasis Therapeutics, Inc.Inventors: Qun Dang, Srinivas Rao Kasibhatla, K. Raja Reddy, Mark D. Erion, M. Rami Reddy, Atul Agurwal
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Patent number: 7301023Abstract: A method for resolving enantiomers of a compound containing the structure of the forula: wherein R4 or R5 may contan one or more asymmetric centers, by mixing a racemic mixture of enantiomers of a compound, containing the structure of said formula; in a solvent, with a resolving compound having a defined sterospecificity, to form a solution and with said resolving agent being capable of binding with at least one but not all of said enantiomers to form a precipitate, containing said at least one of said enantiomers in sterospecific form and collecting either the precipitate and purifying it or collecting the solution with contained other of said enantiomers and recrystallizing the enantiomer contained in said solution.Type: GrantFiled: May 23, 2002Date of Patent: November 27, 2007Assignee: Pfizer Inc.Inventors: Mark E. Flanagan, Michael J. Munchhof
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Patent number: 7276604Abstract: The present invention relates to a crystalline, hydrated form of the sodium salt of 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid. The hydrate contains from 6.4 up to 22 weight % of sodium and 15 up to 23 weight % of crystalline water if the sodium content is lower than 7.5 weight %, based on the whole molecule, or 4.5 up to 18 weight % of crystalline water if the sodium content is equal to or higher than 13 weight %, based on the anhydrous substance. Due to stability in humid environments, the hydrate is useful as an active substance for the treatment of diseases associated with bone resorption disorders.Type: GrantFiled: October 21, 2003Date of Patent: October 2, 2007Assignee: Zentiva A.S.Inventors: Jindrich Richter, Josef Jirman
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Patent number: 7268124Abstract: The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use.Type: GrantFiled: August 25, 2005Date of Patent: September 11, 2007Assignee: University of Iowa Research FoundationInventors: David F. Wiemer, Raymond J. Hohl
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Publication number: 20070197478Abstract: The present invention relates to immune response modifiers of formula (I), which act selectively through agonism, of Toll-Like Receptors (TLRs), uses thereof, processes for the preparation thereof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infection and cancer.Type: ApplicationFiled: February 16, 2007Publication date: August 23, 2007Inventors: Peter Jones, David Pryde, Thien Duc Tran
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Publication number: 20070191606Abstract: The present invention provides novel 2,2-bis(4-hydroxyphenyl)-alkyl onium salts as illustrated by 2,2-bis(4-hydroxyphenyl)-tridecyl(1,2-dimethylimidazolium)bromide and a process for preparation thereof by hydroxyalkylating acetoacetate to the corresponding hyroxyalkylacetoacetate, dealkoxycarbonylating the hydroxyalkyl acetoacetate to ?-hydroxyalkan-2-one and contacting the ?-hydroxyalkan-2-one with phenol in the presence of an acidic catalyst to give 2,2-bis(4-hydroxyphenyl)alkanol, brominating the 2,2-bis(4-hydroxyphenyl)alkanol to 2,2-bis(4-hydroxyphenyl)alkyl bromide, quaternizing 1,2-dimethylimidazole with the 2,2-bis(4-hydroxyphenyl)alkyl bromide to 2,2-bis(4-hydroxyphenyl)alkyl(1,2-dimethylimidazolium)bromide. The products can be used as reactive modifiers for layered phyllosilicates that can be used in the preparation of polymer-nanocomposites, wherein the said polymers are prepared from 2,2-bis(4-hydroxyphenyl)propane as one of the reacting monomers.Type: ApplicationFiled: October 13, 2006Publication date: August 16, 2007Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Shroff Rama Mallikarjuna, Swaminathan Sivaram