Polycyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos Patents (Class 546/23)
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Patent number: 4670422Abstract: Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.Type: GrantFiled: March 27, 1986Date of Patent: June 2, 1987Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Tamara Dejneka
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Patent number: 4659657Abstract: Compounds of the formula ##STR1## wherein Y is ##STR2## M is hydrogen, or an alkali metal or ammonium ion, X is --O-- or an amino group,R is H, Cl, Br, CN or carbamoyl,R.sup.1 is H or --SO.sub.3 H, andA is one of several particular organic radicals,are especially useful in the photometric or fluorimetric determination of phosphatase or sulphatase activity in a liquid sample.Type: GrantFiled: December 14, 1983Date of Patent: April 21, 1987Assignee: Bayer AktiengesellschaftInventors: Horst Harnisch, Otto S. Wolfbeis
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Patent number: 4650791Abstract: A novel phospholipid of the formula: ##STR1## wherein R.sup.1 is an alkyl group of 10 to 24 carbon atoms, R.sup.2 is a cyclic imide group and A.sup.+ is a cyclic ammonio group and a salt thereof have platelet activating factor inhibiting activity and are useful for prevention and treatment of circulatory disorders and allergic bronchial asthma.Type: GrantFiled: January 8, 1985Date of Patent: March 17, 1987Assignee: Takedo Chemical Industries, Ltd.Inventors: Hiroaki Nomura, Kohei Nishikawa, Susumu Tsushima
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Patent number: 4649203Abstract: Novel ketoalkylphospholipids, inclusive of salts thereof, of the formula ##STR1## wherein R.sup.1 is an aliphatic hydrocarbon residue containing 10 to 20 carbon atoms,R.sup.2 is hydrogen or methoxy, andR.sup.3, R.sup.4 and R.sup.5 are independently hydrogen or C.sub.1-5 alkyl, or ##STR2## represents a cyclic ammonio group, exhibit inhibitory activity against multiplication of tumor cells and antifungal activity.Type: GrantFiled: March 27, 1986Date of Patent: March 10, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Shoshichi Nojima, Hiroaki Nomura, Susumu Tsushima
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Patent number: 4619917Abstract: The invention discloses certain substituted 2-furanyl- or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-induced blood platelet aggregation, PAF-mediated bronchoconstriction and extravasation, PAF-induced hypotension and PAF-induced ischemic bowel disease.Type: GrantFiled: October 31, 1985Date of Patent: October 28, 1986Assignee: Sandoz Pharm. Corp.Inventors: Mark L. Lee, Christian Jaeggi
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Patent number: 4603125Abstract: Compounds represented by the general formula (I): ##STR1## in which R.sub.1 represents ##STR2## A and B each represent H or a lower alkane optionally substituted with amino and/or hydroxyl functions, except that A and B are not both H; R.sub.3 represents H, OCH.sub.3, CH.sub.3, halogen, NH.sub.2, NO.sub.2, NHCH.sub.3, N.sub.3 (CH.sub.3).sub.2, N.sub.3, NHCOCH.sub.3, NHCOOCH.sub.3, N(CH.sub.3)COOCH.sub.3, CONH.sub.2 or CONHCH.sub.3 ; R.sub.4 represents H, alkyl, O-alkyl, CONH.sub.2, CONHCH.sub.3 or CONHCH.sub.2 CONHCH.sub.3, except that R.sub.3 and R.sub.4 taken together can represent --C.dbd.CH--CH.dbd.N--; R.sub.5 represents H, alkyl, O-alkyl, CONH.sub.2, CONHCH.sub.3 or CONH.sub.2 CH.sub.2 CONHCH.sub.3 ; R.sub.6 represents lower alkyl; R.sub.7 represents CH.sub.3 or C.sub.6 H.sub.5 (phenyl); R.sub.8 represents lower alkyl or C.sub.6 H.sub.5 (phenyl); R.sub.9 represents H, NHCOCH.sub.3, NH.sub.2 or N.dbd.CHN(CH.sub.3).sub.2 ; and R.sub.10 represents H or NH.sub.Type: GrantFiled: November 14, 1983Date of Patent: July 29, 1986Assignee: Development Finance Corporation of New ZealandInventors: Graham J. Atwell, Bruce C. Baguley, William A. Denny, Gordon W. Rewcastle
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Patent number: 4594199Abstract: A method is provided for preparing phosphinic acid prodrug intermediates which are useful in preparing phosphinic acid angiotensin-converting enzyme inhibitors which method includes the step of coupling a phosphonous acid or its ester of the structure ##STR1## wherein R is H or lower alkyl and R.sup.1 is lower alkyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl, with a conjugated compound of the structure ##STR2## wherein R.sup.2, R.sup.3 and R.sup.4 may be the same or different and each is independently H, lower alkyl or aryl, and Z is --CO.sub.2 R.sup.5 (wherein R.sup.5 is H or lower alkyl), ##STR3## (wherein R.sup.6 is H, lower alkyl aryl or arylalkyl), ##STR4## (wherein R.sup.7 and R.sup.8 are the same or different and are selected from the group consisting of H, lower alkyl, aryl, aryl-lower alkyl, cycloalkyl or cycloalkylalkyl and at least one of R.sup.7 and R.sup.8 is other than H, or R.sup.7 and R.sup.Type: GrantFiled: January 22, 1985Date of Patent: June 10, 1986Assignee: E. R. Squibb & Sons, Inc.Inventor: John K. Thottathil
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Patent number: 4569997Abstract: By reacting compounds of the formula ##STR1## with diisocyanates or triisocyanates of the formula R.sup.4 (NCO).sub.n at a low temperature, the corresponding 1-carbamyl compounds of the formula I ##STR2## in which n is 2 or 3 and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in claim 1, are obtained. The compounds of the formula 1 are light stabilizers for organic materials, especially for varnishes.Type: GrantFiled: September 29, 1983Date of Patent: February 11, 1986Assignee: Ciba Geigy CorporationInventor: Friedrich Karrer
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Patent number: 4567166Abstract: Compounds of the formula ##STR1## wherein X is an amino acid or ester are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: March 19, 1984Date of Patent: January 28, 1986Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4560681Abstract: This invention is directed to phosphinylmethylaminocarbonyl imino acid compounds of the formula ##STR1## wherein X represents various unsubstituted or substituted imino acids or esters.Type: GrantFiled: March 9, 1984Date of Patent: December 24, 1985Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
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Patent number: 4560680Abstract: Compounds of the structure ##STR1## are provided which are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.Type: GrantFiled: May 10, 1984Date of Patent: December 24, 1985Assignee: E. R. Squibb & Sons, Inc.Inventors: Denis E. Ryono, Edward W. Petrillo, Jr.
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Patent number: 4560752Abstract: Novel 5-(substituted amino)phenoxyalkyl-, phenylthioalkyl-, phenylsulfinylalkyl-, and phenylsulfonylalkylphosphinates and phosphonates, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.Type: GrantFiled: June 28, 1984Date of Patent: December 24, 1985Assignee: Zoecon CorporationInventor: Shy-Fuh Lee
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Patent number: 4551532Abstract: New ethylene glycol derivatives, inclusive of salts thereof, which have the formula: ##STR1## wherein n is an integer of 1 to 15; R.sup.1 is an aliphatic hydrocarbon group containing 6 to 26 carbon atoms; R.sup.2, R.sup.3 and R.sup.4 are independently H or lower alkyl, or ##STR2## represents a cyclic ammonio group, exhibit inhibitory activity to multiplication of tumor cells and antimicrobial activity.Type: GrantFiled: April 27, 1981Date of Patent: November 5, 1985Assignee: Takeda Chemical Industries, Ltd.Inventors: Motoo Hozumi, Hiroaki Nomura, Yoshio Yoshioka
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Patent number: 4542219Abstract: Ethylene glycol derivatives, inclusive of salts thereof, which have the formula: ##STR1## wherein R.sup.1 is C.sub.8-26 aliphatic hydrocarbon residue; R.sup.2, R.sup.3 and R.sup.4 are each hydrogen or lower alkyl which may be substituted, or --N.sup.+ R.sup.2 R.sup.3 R.sup.4 represents cyclic ammonio, exhibit inhibitory activity to multiplication of tumor cells and antimicrobial activity.Type: GrantFiled: March 24, 1982Date of Patent: September 17, 1985Assignee: Takeda Chemical Industries, Ltd.Inventors: Motoo Hozumi, Hiroaki Nomura, Yoshio Yoshioka
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Patent number: 4499271Abstract: 3-Phosphinyloxy-4-substituted phenoxy alkenoic acid esters, derivatives thereof, and the use thereof for the control of weeds.Type: GrantFiled: August 20, 1982Date of Patent: February 12, 1985Assignee: Zoecon CorporationInventors: Gustave K. Kohn, Joe T. Bamberg
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Patent number: 4496730Abstract: Phosphorous diketonate electron accepting compounds are disclosed for use as sensitizers in electron donating photoconductive compositions. Methine dyes having a phosphorous diketonate component and a method of making same are also disclosed.Type: GrantFiled: September 20, 1982Date of Patent: January 29, 1985Assignee: Eastman Kodak CompanyInventors: Chin H. Chen, Thomas E. Goliber, Jerome H. Perlstein, George A. Reynolds
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Patent number: 4486587Abstract: A process for concentrating light over a particular area by means of fluorescent compounds in plastic plates or films, wherein the fluorescent compounds used are those of the formula ##STR1## where Z is .dbd.N-- or .dbd.CH--, Y is --OSO.sub.2 R.sup.1, ##STR2## --OCOR.sup.1 or --OR.sup.3, or 2 Y together are ##STR3## where R is alkyl, X is fluorine, chlorine, C.sub.1 -C.sub.20 -alkyl, C.sub.3 -C.sub.20 -alkenyl, aralkyl, --COR.sup.1, --SO.sub.2 R.sup.1, --OPO(OR.sup.2).sub.2, --NH--COR.sup.1 or --NH--SO.sub.2 --R.sup.1, m is 2, 3 or 4, n is 0, 1 or 2, R.sup.1 is unsubstituted or substituted alkyl, alkenyl or an aromatic or heteroaromatic radical and, when Y is --OCOR.sup.1, may furthermore be alkoxy or cycloalkoxy, R.sup.2 is alkyl or cycloalkyl and R.sup.3 is alkyl, alkenyl, C.sub.2 - or C.sub.3 -alkylenecarboalkoxy, alkyl-substituted benzyl or cyclohexyl or a monocyclic, bicyclic or polycyclic saturated hydrocarbon radical.Some of the compounds I and II are new.Type: GrantFiled: August 20, 1982Date of Patent: December 4, 1984Assignee: BASF AktiengesellschaftInventor: Guenther Seybold
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Patent number: 4479000Abstract: The novel class of compounds of the present invention represented by the general formula (I): ##STR1## in which R.sub.1 represents H or OCH.sub.3,R.sub.2 represents H, OCH.sub.3, CH.sub.3, halogen, NO.sub.2, NH.sub.2, NHCOCH.sub.3 or NHCOOCH.sub.3, andR.sub.3 and R.sub.4 individually represent H, CH.sub.3, OCH.sub.3 or CONHCH.sub.3,and the acid addition salts thereof, have unexpectedly high potency and activity in in vivo antitumour tests. The compounds are also bacteriostatic, and show toxicity towards mouse, hamster and human tumour cell lines in culture.Type: GrantFiled: August 19, 1982Date of Patent: October 23, 1984Assignee: Development Finance Corporation of New ZealandInventors: Gordon W. Rewcastle, Graham J. Atwell, Bruce C. Baguley, William A. Denny
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Patent number: 4474774Abstract: This invention discloses new insecticidal chemical compounds of the following formula and their use in controlling insects: ##STR1## wherein X and Y are each independently selected from the group consisting of halogen, alkyl, haloalkyl, nitro, alkylsulfinyl, alkylsulfonyl and cyano; m and n are integers from 0 to 3; R.sup.1 is selected from the group consisting of alkyl and ##STR2## wherein R.sup.3 is selected from the group consisting of halogen, alkyl, haloalkyl, nitro and cyano; and k is an integer from 0 to 3; R.sup.2 is selected from the group consisting of alkyl, alkoxy, alkylthio, amino, alkylamino, dialkylamino and ##STR3## wherein R.sup.4 is selected from the group consisting of halogen, alkyl, haloalkyl, nitro and cyano; and t is an integer from 0 to 3; and A and B are each independently selected from the group consisting of oxygen and sulfur.Type: GrantFiled: January 31, 1983Date of Patent: October 2, 1984Assignee: Velsicol Chemical CorporationInventor: James T. Traxler
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Patent number: 4452790Abstract: Phosphonyl hydroxyacyl amino acids of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents.Type: GrantFiled: June 23, 1982Date of Patent: June 5, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4452792Abstract: This invention discloses new insecticidal chemical compounds of the following formula and their use in controlling insects: ##STR1## wherein X and Y are each independently selected from the group consisting of halogen, alkyl, haloalkyl, nitro, alkylsulfinyl, alkylsulfonyl and cyano; m and n are integers from 0 to 3; R.sup.1 is selected from the group consisting of alkyl and ##STR2## wherein R.sup.3 is selected from the group consisting of halogen, alkyl, haloalkyl, nitro and cyano; and k is an integer from 0 to 3; R.sup.2 is selected from the group consisting of alkyl, alkoxy, alkylthio, amino, alkylamino, dialkylamino and ##STR3## wherein R.sup.4 is selected from the group consisting of halogen, alkyl, haloalkyl, nitro and cyano; and t is an integer from 0 to 3; and A and B are each independently selected from the group consisting of oxygen and sulfur.Type: GrantFiled: December 27, 1982Date of Patent: June 5, 1984Assignee: Velsicol Chemical CorporationInventor: James T. Traxler
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Patent number: 4452791Abstract: Compounds of the structure ##STR1## are provided which are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.Type: GrantFiled: March 15, 1982Date of Patent: June 5, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Denis E. Ryono, Edward W. Petrillo, Jr.
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Patent number: 4448772Abstract: This invention is directed to phosphinylmethylaminocarbonyl imino acid compounds of the formula ##STR1## wherein X represents various unsubstituted or substituted imino acids or esters.Type: GrantFiled: April 22, 1982Date of Patent: May 15, 1984Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
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Patent number: 4444765Abstract: Compounds of the formula ##STR1## wherein X is an amino acid or ester are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: July 14, 1982Date of Patent: April 24, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4432971Abstract: Phosphonamidates of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents.Type: GrantFiled: June 28, 1982Date of Patent: February 21, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4427665Abstract: Phosphinylalkanoyl imino acids of the formula ##STR1## wherein X is tetrahydroisoquinoline carboxylic acid, dihydroindole or dihydroisoindole carboxylic acid are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: May 19, 1982Date of Patent: January 24, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4370320Abstract: Phosphoric and phosphonic acid derivatives of substituted 4-hydroxyquinolines of the formula ##STR1## in which R.sup.1 denotes alkyl, alkoxy, alkylthio, (di)alkylamino or phenyl, R.sup.2 and R.sup.4 denote alkyl, R.sup.3 denotes H, halogen, carbalkoxy, substituted carbonamido or CN, R.sup.5 denotes H, halogen, NO.sub.2, alkyl, alkoxy or CF.sub.3 and X denotes O or S, are effective insecticides and fungicides.Type: GrantFiled: September 18, 1981Date of Patent: January 25, 1983Assignee: Hoechst AktiengesellschaftInventors: Horst Gildemeister, Hilmar Mildenberger, Werner Knauf, Anna Waltersdorfer, Burkhard Sachse
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Patent number: 4308399Abstract: A compound effective in the treatment of diabetic angiopathy, i.e. a selective .beta.-receptor blocker has the formula ##STR1## wherein: R.sup.2 is a hydrogen or alkyl having one to five carbon atoms,R.sup.3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phenyl, or R.sup.2 and R.sup.3 together form a five- to eight-membered ring optionally containing also other heteroatoms and/or fused with another ring, preferably phenyl, naphthyl, quinolyl, isoquinolyl, pyridyl, pyrazolyl,R.sup.5 is hydrogen or alkyl having one to four carbon atoms, cycloalkyl or phenyl optionally substituted with halogen, alkoxy having one to four carbon atoms or alkyl having one to four carbons,R.sup.6 is hydrogen, alkyl having one to four carbon atoms or phenyl, m=0, 1 or 2, and n=0, 1 or 2.Type: GrantFiled: July 5, 1979Date of Patent: December 29, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Kalman Takacs, Peter N. Literati, Ilona Kiss nee Ajzert, Antal Simay, Matyas Szentivanyi, Sandor Virag, Katalin Farago
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Patent number: 4298602Abstract: Compounds are prepared which correspond to the formula ##STR1## wherein R represents a nitrogen containing heterocyclic radical corresponding to one of the formulae ##STR2## each X independently represents chloro, fluoro, bromo, nitro, alkyl of 1 to 4 carbon atoms, amino, mono- or dialkylamino wherein each alkyl group independently contains from 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, alkylsulfinyl of 1 to 4 carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms, cyano, trifluoromethyl, trichloromethyl, phenoxy or substituted phenoxy of the formula ##STR3## wherein each Z independently represents chloro, fluoro, bromo, nitro, cyano, alkoxy of 1 to 4 carbon atoms or alkylthio of 1 to 4 carbon atoms, with the proviso that when either n is 2 or 3, all X groups are sterically compatible with each other and all Z groups are sterically compatible with each other; Y represents oxygen or sulfur; each n can independently represent an integer of from 0 to 3, inclusive; R.sup.Type: GrantFiled: October 15, 1979Date of Patent: November 3, 1981Assignee: The Dow Chemical CompanyInventor: Chester E. Pawloski
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Patent number: 4293466Abstract: New derivatives of N,N'-4-piperidyl-tetraalkyl-substituted alkylene diamines are disclosed. These new compounds are useful for stabilizing thermoplastic polymers, in particular polyolefins, against sunlight, heat and oxidation. A process for producing the new compounds is also disclosed, as well as the use thereof as stabilizers of polymers and polymeric compositions.Type: GrantFiled: December 5, 1978Date of Patent: October 6, 1981Assignee: Montedison S.p.A.Inventors: Piero Di Battista, Renzo Fontanelli, Francesco Gratani, Giuseppe Nelli
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Patent number: 4232030Abstract: Disclosed are substituted N-methylene derivatives of thienamycin sulfoxide (I, n=1) and sulfone (I, n=2) which may be represented by the following structural formula: ##STR1## wherein X and Y are selected from the group consisting of hydrogen, R, OR, SR, and NR.sup.1 R.sup.2 wherein, inter alia, R is substituted or unsubstituted: alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, and heterocyclylalkyl; R.sup.1 and R.sup.2 are hydrogen or R. Such compounds and their pharmaceutically acceptable salt, ether, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.Type: GrantFiled: September 15, 1977Date of Patent: November 4, 1980Assignee: Merck & Co., Inc.Inventors: Burton G. Christensen, William J. Leanza, Kenneth J. Wildonger
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Patent number: 4210584Abstract: Vindesine is prepared by converting 4-desacetyl VLB C-3 carboxhydrazide to the corresponding azide with a nitrite such as n-butyl nitrite in THF and then reacting the thus formed azide with triphenylphosphine to yield an intermediate acyl iminophosphorane, which compound is decomposed with acid to yield vindesine of high purity and in good yield.Type: GrantFiled: January 15, 1979Date of Patent: July 1, 1980Assignee: Eli Lilly and CompanyInventors: Gloria C. Paschal, Gerald L. Thompson
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Patent number: 4187220Abstract: A compound effective in the treatment of diabetic angiopathy, i.e. a selective .beta.-receptor blocker has the formula ##STR1## wherein: R.sup.2 is a hydrogen or alkyl having one to five carbon atoms, R.sup.3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phenyl, or R.sup.2 and R.sup.3 together form a five- to eight-membered ring optionally containing also other heteroatoms and/or fused with an other ring, preferably phenyl, naphthyl, quinolyl, isoquinolyl, pyridyl, pyrazolyl, R.sup.5 is hydrogen or alkyl having one to four carbon atoms, cycloalkyl or phenyl optionally substituted with halogen, alkoxy having one to four carbon atoms or alkyl having one to four carbon atoms, R.sup.6 is hydrogen, alkyl having one to four carbon atoms or phenyl, m=0, 1 or 2, and n=0, 1 or 2.Type: GrantFiled: August 30, 1977Date of Patent: February 5, 1980Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Kalman Takacs, Peter N. Literati, Ilona Kiss nee Ajzert, Antal Simay, Matyas Szentivanyi, Sandor Virag, Katalin Farago
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Patent number: 4160828Abstract: A phosphinyl derivative of formula (I) ##STR1## wherein X is =CH-- or =N--,R.sup.1 is(a) phenyl radical,(b) a quinolyl radical,(c) one of the radicals (a) and (b) being substituted by at least one substituent selected from the group consisting of halogen, trifluoromethyl and 1 to 3 alkyl radicals having in total up to 4 carbon atoms,R.sup.2 is selected from the group consisting of a dialkyl-phosphinylalkyl radical and a dialkyl phosphinyl-hydroxyalkyl radical each of said radicals R.sup.2 having a total of from 3 to 7 carbon atomsAnd acid addition salts thereof, pharmaceutical preparations containing said derivatives.Type: GrantFiled: February 10, 1978Date of Patent: July 10, 1979Assignee: Hoechst AktiengesellschaftInventors: Alfons Soder, Klaus Perrey