The -oh Or -om Is Bonded To An Acyclic Carbon, Which Carbon Is Bonded Directly To Two Rings Patents (Class 546/241)
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Publication number: 20150038533Abstract: The invention relates to the treatment of an attention deficit hyperactivity disorder (ADHD) with alpha-phenyl(piperidin-2-yl)methanol, or the pharmaceutically acceptable salts and esters thereof, in particular the acetate derivative, more particularly dextrophacetoperane. The invention additionally provides a method of synthesis of the (S,S) enantiomer of alpha-phenyl(piperidin-2-yl)methanol as well as a method of synthesis of dextrophacetoperane.Type: ApplicationFiled: November 29, 2012Publication date: February 5, 2015Inventors: Eric Konofal, Bruno Figadere
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Publication number: 20140271527Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.Type: ApplicationFiled: November 1, 2012Publication date: September 18, 2014Applicant: Serina Therapeutics, Inc.Inventors: Randall Moreadith, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley
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Patent number: 8557998Abstract: Disclosed is a benzylpiperizine compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which is useful as a medicinal agent such as an antidepressant agent. (In the formula (1), R1 represents a hydrogen atom or a methyl group; R2 is a group bound in a p- or m-position relative to a methylene group and represents a chlorine atom bound in a p-position, a bromine atom bound in a p-position, a methyl group bound in a p-position, a chlorine atom bound in a m-position or a bromine atom bound to in a m-position; X represents a methylene or an oxygen atom; and n represents an integer of 1 to 3.Type: GrantFiled: June 20, 2012Date of Patent: October 15, 2013Assignee: Dainippon Sumitomo Pharma Co., LtdInventor: Tomohiro Toyoda
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Publication number: 20130252947Abstract: The present disclosure relates to a method to stimulate endogenous BMP-2 up-regulation in a subject which method comprises administering to a subject an effective amount of an H1 receptor antagonist, whereby endogenous BMP-2 up-regulation is stimulated in said subject. Also provided is a pharmaceutical formulation including an H1 receptor antagonist present in an effective amount to stimulate BMP-2 up-regulation in a subject and a kit.Type: ApplicationFiled: May 17, 2013Publication date: September 26, 2013Applicant: Southwest Research InstituteInventor: Jorge Gianny ROSSINI
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Patent number: 8501778Abstract: The present invention relates to aralkyl piperidine derivatives, compositions containing the same, and their uses in the preparation of antalgic or ataractic medicament. The said derivatives are a free base of the compound represented by the following formula or a salt thereof. The pharmacological experiments show that they display favorable antalgic, ataractic activity and low side effects.Type: GrantFiled: June 20, 2008Date of Patent: August 6, 2013Assignees: NHWA Pharma. Corporation, Shanhai Institute of Pharmaceutical IndustryInventors: Jianqi Li, Guan Wang, Guisen Zhang, Yanqin Ma, Wenhua Ji, Yuan Zhang, Lin Guo
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Patent number: 8067605Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.Type: GrantFiled: November 30, 2010Date of Patent: November 29, 2011Assignee: Albany Molecular Research, Inc.Inventors: Harold Meckler, Benjamin J. Littler, Prasad Raje, Michael Van Brundt, Paul Vogt
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Publication number: 20110071295Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.Type: ApplicationFiled: November 30, 2010Publication date: March 24, 2011Applicant: ALBANY MOLECULAR RESEARCH, INC.Inventors: Harold MECKLER, Ben Littler, Prasad Raje, Michael Van Brunt, Paul F. Vogt
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Publication number: 20100191475Abstract: Materials, methods and a computer system are provided which facilitate the identification and characterization of modulators of potassium ion channels, particularly the HERG channel.Type: ApplicationFiled: March 4, 2010Publication date: July 29, 2010Inventors: Scott Perschke, Ming Liu
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Patent number: 7763639Abstract: The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho, meta-disubstituted phenyl)-1-alkypiperidines and piperazines. wherein R1, R2, R3 and X are as defined.Type: GrantFiled: December 8, 2006Date of Patent: July 27, 2010Assignee: NSAB, Filial AF Neurosearch Sweden AB, SverigeInventors: Clas Sonesson, Lars Swanson, Nicholas Ross Waters
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Patent number: 7691615Abstract: The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is —COOH or —COOR4; R4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy. This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB: wherein R3 is —CH3 and R1, R2, A, B, and D are defined above in the presence of a microorganism under conditions effective to produce the product compound.Type: GrantFiled: January 17, 2007Date of Patent: April 6, 2010Assignee: Albany Molecular Research, Inc.Inventors: Peter C. Michels, Eric L. Zirbes
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Publication number: 20090227798Abstract: The present invention provides various processes for the preparation of (R)-?-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.Type: ApplicationFiled: March 13, 2009Publication date: September 10, 2009Applicants: SANOFI-AVENTIS DEUTSCHLAND GMBH, AVENTIS PHARMACEUTICALS INC.Inventors: Wolfgang Laux, Gerard Guillamot, Frederick M. Laskovics, Chi-Hsin R. King, James E. Hitt, Sandra K. Stolz-Dunn, Ian A. Tomlinson, Johannes Nicolaas Koek
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Publication number: 20090221830Abstract: Anhydrous crystalline fexofenadine hydrochloride Form C, crystalline fexofenadine acetate monohydrate Form D, crystalline fexofenadine acetate dihydrate Form E and crystalline fexofenadine free base monohydrate Form F, processes of preparing the same, pharmaceutical compositions thereof, therapeutic uses thereof and methods of treatment therewith.Type: ApplicationFiled: November 19, 2008Publication date: September 3, 2009Applicant: Cipla LimitedInventors: Dharmaraj Ramachandra RAO, Rajendra Narayanrao KANKAN, Manish Gopaldas GANGRADE, Dilip Ramdas BIRARI
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Publication number: 20090124810Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.Type: ApplicationFiled: January 20, 2009Publication date: May 14, 2009Applicant: ALBANY MOLECULAR RESEARCH, INC.Inventors: Harold Meckler, Ben Littler, Prasad Raje, Michael van Brunt, Paul F. Vogt
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Patent number: 7378412Abstract: Compounds or their salts having general formula: A-B—C—NO2 wherein: A is a drug radical; B is a linker; and C is a bivalent radical.Type: GrantFiled: December 30, 2004Date of Patent: May 27, 2008Assignee: Nicox S.A.Inventor: Piero Del Soldato
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Patent number: 7232908Abstract: The present invention relates to a process for the production of piperidine derivatives with microorganisms. This is carried out by incubating starting compounds in the presence of a microorganism under conditions effective to produce piperidine derivative products. Suitable microorganisms can be from any one of the genus of Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Pseudomonas, Helicostylum, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, and Penicillium. In another aspect of the invention, starting compounds are incubated in the presence of Cunninghamella bainieria under conditions effective to produce piperidine derivative products.Type: GrantFiled: August 11, 2003Date of Patent: June 19, 2007Assignee: AMR Technology, Inc.Inventors: Peter C. Michels, Eric L. Zirbes
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Patent number: 7122539Abstract: Nitric acid salts with medicines active in the respiratory system pathology treatment.Type: GrantFiled: December 17, 2003Date of Patent: October 17, 2006Assignee: Nicox S.A.Inventor: Piero Del Soldato
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Patent number: 6797826Abstract: The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; R3 is —COOH or —COOR4; R4 has 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents. A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.Type: GrantFiled: September 4, 2002Date of Patent: September 28, 2004Assignee: AMR Technology, Inc.Inventor: Thomas E. D'Ambra
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Publication number: 20040152900Abstract: The present invention is directed to the method of isolation of sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT2A antagonist (+)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.Type: ApplicationFiled: January 20, 2004Publication date: August 5, 2004Applicant: Aventis Pharmaceuticals Inc.Inventors: Ronald Charles Bernotas, Paul Wayne Brown, Gary Thomas Emmons, Chi-Hsin Richard King
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Publication number: 20040132744Abstract: Nitric acid salts with medicines active in the respiratory system pathology treatment.Type: ApplicationFiled: December 17, 2003Publication date: July 8, 2004Applicant: Nicox S.A.Inventor: Piero Del Soldato
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Publication number: 20040102634Abstract: The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them.Type: ApplicationFiled: October 22, 2003Publication date: May 27, 2004Inventors: Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Sakai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Safakazu Miyashita, Taro Hihara, Hitoshi Harada, Kaya Ohashi
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Patent number: 6716986Abstract: The present invention is directed to sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT2A antagonist (+)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and a processes for its preparation and its use in the treatment for a number of disease states.Type: GrantFiled: July 22, 2002Date of Patent: April 6, 2004Assignee: Aventis Pharmaceuticals Inc.Inventors: Ronald Charles Bernotas, Paul Wayne Brown, Gary Thomas Emmons, Chi-Hsin Richard King
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Patent number: 6713627Abstract: The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.Type: GrantFiled: January 11, 2002Date of Patent: March 30, 2004Assignee: Aventis Pharmaceuticals Inc.Inventors: Edward D. Daugs, Jonathan C. Evans, Hans-Wolfram Flemming, Thomas Heinz Eduard Hilpert, Johannes Nicolaas Koek, Frederick M. Laskovics, Sandra K. Stolz-Dunn, Ian A. Tomlinson
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Publication number: 20040058955Abstract: The present invention provides novel crystal forms of fexofenadine hydrochloride Forms V, VI and VIII through XV and processes for their preparation and preparation of amorphous form and other crystalline forms of fexofenadine hydrochloride. Forms XIV and XV are solvates of ethyl acetate, while Form IX is anhydrous, but can be crystallized as a solvate of MTBE or cyclohexane. The forms are useful for administration to humans and animals to alleviate symptoms caused by histamine. The present invention further provides pharmaceutical compositions of the new crystalline forms.Type: ApplicationFiled: September 12, 2003Publication date: March 25, 2004Inventors: Ben-Zon Dolitzky, Shlomit Wizel, Barnaba Krochmal, Dov Diller, Irwin Gross
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Patent number: 6683094Abstract: This invention relates to novel piperidine derivatives of formula (I) and a process for the preparation thereof. wherein R1 is H or C1-C6alkyl wherein the C1-C6alkyl moiety is straight or branched; R2 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; or stereoisomers or pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: June 12, 2002Date of Patent: January 27, 2004Assignee: Aventis Pharmaceuticals Inc.Inventors: Timothy A. Ayers, Paul W. Brown
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Publication number: 20040014976Abstract: The present invention is related to novel processes for preparing anhydrous and hydrated forms of piperidine derivatives, polymorphs and pseudomorphs thereof of the formulas 1Type: ApplicationFiled: March 10, 2003Publication date: January 22, 2004Inventors: Daniel R. Henton, Frederick J. McCarty, Susan I. Tripp, Jill E. DeWitt
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Publication number: 20030204084Abstract: A process comprising allowing a peroxide compound represented by following Formula (2): 1Type: ApplicationFiled: March 6, 2003Publication date: October 30, 2003Inventors: Yasutaka Ishii, Tatsuya Nakano
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Publication number: 20030171590Abstract: The present invention discloses processes for preparing piperidine derivative compounds of the formulae: 1Type: ApplicationFiled: August 5, 2002Publication date: September 11, 2003Inventors: Thomas E. D'Ambra, Garry M. Pilling
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Patent number: 6613907Abstract: The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is —COOH or —COOR4; R4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy. This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB: wherein R3 is —CH3 and R1, R2, A, B, and D are defined above In the presence of a microorganism under conditions effective to produce the product compound.Type: GrantFiled: January 4, 2001Date of Patent: September 2, 2003Assignee: AMR Technology, Inc.Inventors: Peter C. Michels, Eric L. Zirbes
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Patent number: 6605630Abstract: The invention concerns a compound of the formula (I): wherein, for example: T is of the formula (IA), (IB), or (IC); R1 is of the formula —NHC(═O)Rb wherein Rb is (1-4C)alkyl; R2 and R3 are hydrogen or fluoro; >A—B— is >C═CH— (but not when T is (IA)) or >CH—CH2—; wherein when T is of the formula (IA) or (IB); R6 is, for example, (1-4C)alkyl; R5 is hydrogen, R10CO—, R10SO2— or R10CS— wherein R10 is, for example, optionally substituted phenyl, or (1-10C)alkyl, or when T is of the formula (IA), (IB); or (IC): R5 and R6 are linked to give a 5- or 6-membered ring which is fused to the ring shown in (IA), (IB), or (IC) so as to give an optionally substituted bicyclic ring; and pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them, and their use as antibacterial agents.Type: GrantFiled: February 18, 2000Date of Patent: August 12, 2003Assignee: Syngenta LimitedInventor: Michael Barry Gravestock
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Publication number: 20030105329Abstract: The present invention relates to processes for preparing certain piperidine derivatives, including fexofenadine (F), the active ingredient in the non-sedating antihistamine sold in the U.S. under the designation “Allegra®”. This invention also relates to novel synthetic intermediates useful in the processes of the present invention.Type: ApplicationFiled: June 11, 2002Publication date: June 5, 2003Inventors: Collin Schroeder, Ryan Huddleston, Richard Charles
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Publication number: 20030087932Abstract: The present invention is directed to sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT2A antagonist (+)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and a processes for its preparation and its use in the treatment for a number of disease states.Type: ApplicationFiled: July 22, 2002Publication date: May 8, 2003Inventors: Ronald C. Bernotas, Paul W. Brown, Gary T. Emmons, Chi-Hsin R. King
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Publication number: 20030065186Abstract: This invention relates to novel substituted piperidine derivatives. More particularly, this invention relates to substituted phenyl 4-substituted-piperidinoalkanol derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.Type: ApplicationFiled: October 3, 2002Publication date: April 3, 2003Inventors: Kah Hiing Ling, Paul Wayne Brown, Robert M. Strom, Richard A. Wolf
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Patent number: 6465490Abstract: The present invention is directed to sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester a metabolite of the 5HT2A antagonist (+)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and a processes for its preparation and its use in the treatment for a number of disease states.Type: GrantFiled: July 13, 2000Date of Patent: October 15, 2002Assignee: Aventis Pharmaceuticals Inc.Inventors: Ronald Charles Bernotas, Paul Wayne Brown, Gary Thomas Emmons, Chi-Hsin Richard King
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Patent number: 6407119Abstract: This invention relates to novel piperidine derivatives of formula (I) and a process for the preparation thereof. wherein R1 is H or C1-C6alkyl wherein the C1-C6alkyl moiety is straight or branched; R2 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; or stereoisomers or pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: November 27, 2000Date of Patent: June 18, 2002Assignee: Aventis Pharmaceuticals Inc.Inventors: Timothy A. Ayers, Paul W. Brown
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Patent number: 6358977Abstract: Disclosed is the use of a compound with Formula (I) wherein n is 2, 3, or 4, and R1, R2, R3, and R4 are each independently hydrogen, C1-6 alkyl, halogen, trifluoromethyl, hydroxy, C1-6 alkoxy or amino, or an optical isomer or a pharmaceutically acceptable salt thereof for the production of a pharmaceutical composition for treatment of a neurodevelopmental disorder. Also a method for treatment of neurodevelopmental disorders wherein a therapeutically effective amount of said compound is administered to a patient is disclosed.Type: GrantFiled: December 4, 2000Date of Patent: March 19, 2002Assignee: A. Carlsson Research ABInventor: Maria Carlsson
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Publication number: 20020016467Abstract: This invention relates to novel substituted piperidine derivatives. More particularly, this invention relates to substituted phenyl 4-substituted-piperidinoalkanol derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.Type: ApplicationFiled: October 2, 2001Publication date: February 7, 2002Inventors: Kah Hiing Ling, Paul Wayne Brown, Robert M. Strom, Richard A. Wolf
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Patent number: 6207681Abstract: A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (R)-trihexyphenidyl. The method comprises administering a therapeutically effective amount of enantiomerically enriched (R)-trihexyphenidyl, or a pharmaceutically acceptable salt thereof, substantially free of the (S)-trihexyphenidyl enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (R)-trihexyphenidyl, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.Type: GrantFiled: December 29, 1998Date of Patent: March 27, 2001Assignee: Sepracor Inc.Inventors: Vincent L. Fabiano, John R. McCullough
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Patent number: 6207835Abstract: Arylmetal compounds are prepared by deprotonation of aromatics which have a hydrogen atom in the ortho position relative to a halogen atom or a trifluoromethoxy group, using a suitable base or by halogen-metal exchange of haloaromatics using a suitable metalating reagent. The arylmetal compounds are prepared in a continuous-flow reactor. The arylmetal compound can be further reacted with an electrophilic reagent.Type: GrantFiled: December 17, 1999Date of Patent: March 27, 2001Assignee: Merck KGaAInventors: Volker Reiffenrath, Hans Christian Stiasny
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Patent number: 6165944Abstract: 4-(3-Heterocyclyl-1-benzoyl)pyrazoles of the formula I ##STR1## where: R.sup.1 and R.sup.3 are each hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, N-alkylaminosulfonyl, N,N-dialkyl)aminosulfonyl, N-alkylsulfonylamino, N-haloalkylsulfonylamino, N-alkyl-N-alkylsulfonylamino or N-alkyl-N-haloalkylsulfonylamino;R.sup.2 is a 5- or 6-membered heterocyclyl radical with or without substitution which comprises 1 to 4 identical or different hetero atoms from the following group: oxygen, sulfur or nitrogen;R.sup.4 is hydrogen, halogen or alkyl;R.sup.5 is substituted pyrazole which is attached in position 4;and agriculturally useful salts thereof; processes for preparing the 4-(3-heterocyclyl-1-benzoyl)pyrazoles; compositions comprising them; and the use of these derivatives or these compositions comprising them for controlling undesirable plants.Type: GrantFiled: June 16, 1998Date of Patent: December 26, 2000Assignee: BASF AktiengesellschaftInventors: Wolfgang von Deyn, Regina Luise Hill, Ernst Baumann, Stefan Engel, Guido Mayer, Joachim Rheinheimer, Matthias Witschel, Ulf Misslitz, Oliver Wagner, Martina Otten, Helmut Walter, Karl-Otto Westphalen
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Patent number: 6133259Abstract: Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.Type: GrantFiled: November 9, 1998Date of Patent: October 17, 2000Assignee: University of PittsburghInventors: William E. Klunk, Jay W. Pettegrew, Chester A. Mathis, Jr.
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Patent number: 6004980Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states.Type: GrantFiled: November 13, 1998Date of Patent: December 21, 1999Assignee: Merrell Pharmaceuticals, Inc.Inventors: Albert A. Carr, John M. Kane, David A. Hay
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Patent number: 5990127Abstract: The invention relates to the preparation of the compound 4-(4-(4-(hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-.alpha.,.alpha.-d imethylphenylacetic acid and its phosphorylated derivatives. These compounds can be prepared from .alpha.-(p-tert-butylphenyl)-4-(.alpha.-hydroxy-.alpha.-phenylbenzyl)-1-pi peridinylbutanol with the aid of fungi of the genus Cunninghamella or Absidia. The compounds according to the present invention can be used as pharmaceuticals for the treatment of allergic disorders, allergic rhinitis or asthma. Compounds of the formula II in which R.sup.1 is --CH.sub.2 --O--P(O)(OH).sub.2 and R.sup.2 is --OH; R.sup.1 is --CH.sub.3 and R.sup.2 is --O--P(O)(OH).sub.2 ; orR.sup.1 is --COOH and R.sup.2 is --O--P(O)(OH).sub.2 are produced by the process according to the present invention and are suitable as pharmaceuticals with antihistamine action.Type: GrantFiled: March 9, 1998Date of Patent: November 23, 1999Assignee: Hoechst Marion Roussel Deutschland GmbHInventors: Johannes Meiwes, Manfred Worm
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Patent number: 5981528Abstract: The invention concerns a compound of formula (I): ##STR1## wherein R.sup.1 -R.sup.6, A, B, and D have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising such a compound or salt, and methods of treating a bacterial infection by administering such a compound or salt.Type: GrantFiled: October 21, 1997Date of Patent: November 9, 1999Assignee: Zeneca LimitedInventor: Michael Barry Gravestock
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Patent number: 5777125Abstract: A process for the preparation of tertiary diphenyl carbinols containing a primary or secondary amine substituent on the aliphatic moiety attached to the carbinol function which consists in contacting a Grignard phenyl reagent with an aminoacid wherein the mobile protons are not masked in an aprotic inert organic solvent or a mixture thereof at a temperature between 20.degree. C. and the boiling temperature by the reaction mixture.The reaction products are useful as active ingredients of medicaments and intermediates for the manufacture thereof.Type: GrantFiled: May 24, 1995Date of Patent: July 7, 1998Assignee: Gruppo Lepetit SpAInventor: Elvio Bellasio
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Patent number: 5721249Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.Type: GrantFiled: June 7, 1995Date of Patent: February 24, 1998Assignee: Merrell Pharmaceuticals Inc.Inventors: Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
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Patent number: 5700812Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.Type: GrantFiled: June 7, 1995Date of Patent: December 23, 1997Assignee: Merrell Pharmaceuticals Inc.Inventors: Albert A. Carr, John M. Kane, David A. Hay
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Patent number: 5700813Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.Type: GrantFiled: June 7, 1995Date of Patent: December 23, 1997Assignee: Merrell Pharmaceuticals Inc.Inventors: Albert A. Carr, John M. Kane, David A. Hay
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Patent number: 5683998Abstract: Novel tricyclic triazolo derivatives and pharmaceutically acceptable salts thereof, which are useful as anti-inflammation agents, anti-allergy agents or anti-PAF agents as well as processes for producing the same are disclosed. The triazolo derivatives of the present invention are represented by the formula (I): ##STR1## ?wherein R.sup.1 represents hydrogen, lower alkyl or C.sub.3 -C.sub.5 cycloalkyl; R.sup.2 and R.sup.3 respectively represent hydrogen, lower alkyl, lower alkoxy or halogen; W represents C.dbd.O or CR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 respectively represents hydrogen or lower alkyl); A represents C.sub.1 -C.sub.5 straight or branched saturated or unsaturated alkylene which may contain one or more hetero atoms; l represents 0 to 2, n represents 1 to 3, . . . represents single bond or double bond; Y represents N or C; Z represents C(B)Ar.sup.1 Ar.sup.2 (wherein B represents hydrogen, hydroxy or methoxy, Ar.sup.1 and Ar.sup.Type: GrantFiled: May 2, 1995Date of Patent: November 4, 1997Assignee: Toray Industries, Inc.Inventors: Katsuhiro Shibayama, Tetsuya Makino, Takayuki Imaoka, Tetsuya Katou, Masayuki Kaneko
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Patent number: 5675009Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.Type: GrantFiled: May 1, 1995Date of Patent: October 7, 1997Assignee: Merrell Pharmaceuticals Inc.Inventors: Chi-Hsin Richard King, Michele A. Kaminski
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Patent number: 5663353Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.Type: GrantFiled: May 2, 1995Date of Patent: September 2, 1997Assignee: Merrell Pharmaceuticals Inc.Inventors: Chi-Hsin Richard King, Michele A. Kaminski