The -oh Or -om Is Bonded To An Acyclic Carbon, Which Carbon Is Bonded Directly To Two Rings Patents (Class 546/241)
  • Publication number: 20150038533
    Abstract: The invention relates to the treatment of an attention deficit hyperactivity disorder (ADHD) with alpha-phenyl(piperidin-2-yl)methanol, or the pharmaceutically acceptable salts and esters thereof, in particular the acetate derivative, more particularly dextrophacetoperane. The invention additionally provides a method of synthesis of the (S,S) enantiomer of alpha-phenyl(piperidin-2-yl)methanol as well as a method of synthesis of dextrophacetoperane.
    Type: Application
    Filed: November 29, 2012
    Publication date: February 5, 2015
    Inventors: Eric Konofal, Bruno Figadere
  • Publication number: 20140271527
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
    Type: Application
    Filed: November 1, 2012
    Publication date: September 18, 2014
    Applicant: Serina Therapeutics, Inc.
    Inventors: Randall Moreadith, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley
  • Patent number: 8557998
    Abstract: Disclosed is a benzylpiperizine compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which is useful as a medicinal agent such as an antidepressant agent. (In the formula (1), R1 represents a hydrogen atom or a methyl group; R2 is a group bound in a p- or m-position relative to a methylene group and represents a chlorine atom bound in a p-position, a bromine atom bound in a p-position, a methyl group bound in a p-position, a chlorine atom bound in a m-position or a bromine atom bound to in a m-position; X represents a methylene or an oxygen atom; and n represents an integer of 1 to 3.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: October 15, 2013
    Assignee: Dainippon Sumitomo Pharma Co., Ltd
    Inventor: Tomohiro Toyoda
  • Publication number: 20130252947
    Abstract: The present disclosure relates to a method to stimulate endogenous BMP-2 up-regulation in a subject which method comprises administering to a subject an effective amount of an H1 receptor antagonist, whereby endogenous BMP-2 up-regulation is stimulated in said subject. Also provided is a pharmaceutical formulation including an H1 receptor antagonist present in an effective amount to stimulate BMP-2 up-regulation in a subject and a kit.
    Type: Application
    Filed: May 17, 2013
    Publication date: September 26, 2013
    Applicant: Southwest Research Institute
    Inventor: Jorge Gianny ROSSINI
  • Patent number: 8501778
    Abstract: The present invention relates to aralkyl piperidine derivatives, compositions containing the same, and their uses in the preparation of antalgic or ataractic medicament. The said derivatives are a free base of the compound represented by the following formula or a salt thereof. The pharmacological experiments show that they display favorable antalgic, ataractic activity and low side effects.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: August 6, 2013
    Assignees: NHWA Pharma. Corporation, Shanhai Institute of Pharmaceutical Industry
    Inventors: Jianqi Li, Guan Wang, Guisen Zhang, Yanqin Ma, Wenhua Ji, Yuan Zhang, Lin Guo
  • Patent number: 8067605
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: November 29, 2011
    Assignee: Albany Molecular Research, Inc.
    Inventors: Harold Meckler, Benjamin J. Littler, Prasad Raje, Michael Van Brundt, Paul Vogt
  • Publication number: 20110071295
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.
    Type: Application
    Filed: November 30, 2010
    Publication date: March 24, 2011
    Applicant: ALBANY MOLECULAR RESEARCH, INC.
    Inventors: Harold MECKLER, Ben Littler, Prasad Raje, Michael Van Brunt, Paul F. Vogt
  • Publication number: 20100191475
    Abstract: Materials, methods and a computer system are provided which facilitate the identification and characterization of modulators of potassium ion channels, particularly the HERG channel.
    Type: Application
    Filed: March 4, 2010
    Publication date: July 29, 2010
    Inventors: Scott Perschke, Ming Liu
  • Patent number: 7763639
    Abstract: The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho, meta-disubstituted phenyl)-1-alkypiperidines and piperazines. wherein R1, R2, R3 and X are as defined.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: July 27, 2010
    Assignee: NSAB, Filial AF Neurosearch Sweden AB, Sverige
    Inventors: Clas Sonesson, Lars Swanson, Nicholas Ross Waters
  • Patent number: 7691615
    Abstract: The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is —COOH or —COOR4; R4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy. This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB: wherein R3 is —CH3 and R1, R2, A, B, and D are defined above in the presence of a microorganism under conditions effective to produce the product compound.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: April 6, 2010
    Assignee: Albany Molecular Research, Inc.
    Inventors: Peter C. Michels, Eric L. Zirbes
  • Publication number: 20090227798
    Abstract: The present invention provides various processes for the preparation of (R)-?-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Application
    Filed: March 13, 2009
    Publication date: September 10, 2009
    Applicants: SANOFI-AVENTIS DEUTSCHLAND GMBH, AVENTIS PHARMACEUTICALS INC.
    Inventors: Wolfgang Laux, Gerard Guillamot, Frederick M. Laskovics, Chi-Hsin R. King, James E. Hitt, Sandra K. Stolz-Dunn, Ian A. Tomlinson, Johannes Nicolaas Koek
  • Publication number: 20090221830
    Abstract: Anhydrous crystalline fexofenadine hydrochloride Form C, crystalline fexofenadine acetate monohydrate Form D, crystalline fexofenadine acetate dihydrate Form E and crystalline fexofenadine free base monohydrate Form F, processes of preparing the same, pharmaceutical compositions thereof, therapeutic uses thereof and methods of treatment therewith.
    Type: Application
    Filed: November 19, 2008
    Publication date: September 3, 2009
    Applicant: Cipla Limited
    Inventors: Dharmaraj Ramachandra RAO, Rajendra Narayanrao KANKAN, Manish Gopaldas GANGRADE, Dilip Ramdas BIRARI
  • Publication number: 20090124810
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.
    Type: Application
    Filed: January 20, 2009
    Publication date: May 14, 2009
    Applicant: ALBANY MOLECULAR RESEARCH, INC.
    Inventors: Harold Meckler, Ben Littler, Prasad Raje, Michael van Brunt, Paul F. Vogt
  • Patent number: 7378412
    Abstract: Compounds or their salts having general formula: A-B—C—NO2 wherein: A is a drug radical; B is a linker; and C is a bivalent radical.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: May 27, 2008
    Assignee: Nicox S.A.
    Inventor: Piero Del Soldato
  • Patent number: 7232908
    Abstract: The present invention relates to a process for the production of piperidine derivatives with microorganisms. This is carried out by incubating starting compounds in the presence of a microorganism under conditions effective to produce piperidine derivative products. Suitable microorganisms can be from any one of the genus of Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Pseudomonas, Helicostylum, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, and Penicillium. In another aspect of the invention, starting compounds are incubated in the presence of Cunninghamella bainieria under conditions effective to produce piperidine derivative products.
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: June 19, 2007
    Assignee: AMR Technology, Inc.
    Inventors: Peter C. Michels, Eric L. Zirbes
  • Patent number: 7122539
    Abstract: Nitric acid salts with medicines active in the respiratory system pathology treatment.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: October 17, 2006
    Assignee: Nicox S.A.
    Inventor: Piero Del Soldato
  • Patent number: 6797826
    Abstract: The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; R3 is —COOH or —COOR4; R4 has 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents. A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: September 28, 2004
    Assignee: AMR Technology, Inc.
    Inventor: Thomas E. D'Ambra
  • Publication number: 20040152900
    Abstract: The present invention is directed to the method of isolation of sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT2A antagonist (+)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Application
    Filed: January 20, 2004
    Publication date: August 5, 2004
    Applicant: Aventis Pharmaceuticals Inc.
    Inventors: Ronald Charles Bernotas, Paul Wayne Brown, Gary Thomas Emmons, Chi-Hsin Richard King
  • Publication number: 20040132744
    Abstract: Nitric acid salts with medicines active in the respiratory system pathology treatment.
    Type: Application
    Filed: December 17, 2003
    Publication date: July 8, 2004
    Applicant: Nicox S.A.
    Inventor: Piero Del Soldato
  • Publication number: 20040102634
    Abstract: The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them.
    Type: Application
    Filed: October 22, 2003
    Publication date: May 27, 2004
    Inventors: Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Sakai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Safakazu Miyashita, Taro Hihara, Hitoshi Harada, Kaya Ohashi
  • Patent number: 6716986
    Abstract: The present invention is directed to sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT2A antagonist (+)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and a processes for its preparation and its use in the treatment for a number of disease states.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: April 6, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Ronald Charles Bernotas, Paul Wayne Brown, Gary Thomas Emmons, Chi-Hsin Richard King
  • Patent number: 6713627
    Abstract: The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: March 30, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Edward D. Daugs, Jonathan C. Evans, Hans-Wolfram Flemming, Thomas Heinz Eduard Hilpert, Johannes Nicolaas Koek, Frederick M. Laskovics, Sandra K. Stolz-Dunn, Ian A. Tomlinson
  • Publication number: 20040058955
    Abstract: The present invention provides novel crystal forms of fexofenadine hydrochloride Forms V, VI and VIII through XV and processes for their preparation and preparation of amorphous form and other crystalline forms of fexofenadine hydrochloride. Forms XIV and XV are solvates of ethyl acetate, while Form IX is anhydrous, but can be crystallized as a solvate of MTBE or cyclohexane. The forms are useful for administration to humans and animals to alleviate symptoms caused by histamine. The present invention further provides pharmaceutical compositions of the new crystalline forms.
    Type: Application
    Filed: September 12, 2003
    Publication date: March 25, 2004
    Inventors: Ben-Zon Dolitzky, Shlomit Wizel, Barnaba Krochmal, Dov Diller, Irwin Gross
  • Patent number: 6683094
    Abstract: This invention relates to novel piperidine derivatives of formula (I) and a process for the preparation thereof. wherein R1 is H or C1-C6alkyl wherein the C1-C6alkyl moiety is straight or branched; R2 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; or stereoisomers or pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: January 27, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Timothy A. Ayers, Paul W. Brown
  • Publication number: 20040014976
    Abstract: The present invention is related to novel processes for preparing anhydrous and hydrated forms of piperidine derivatives, polymorphs and pseudomorphs thereof of the formulas 1
    Type: Application
    Filed: March 10, 2003
    Publication date: January 22, 2004
    Inventors: Daniel R. Henton, Frederick J. McCarty, Susan I. Tripp, Jill E. DeWitt
  • Publication number: 20030204084
    Abstract: A process comprising allowing a peroxide compound represented by following Formula (2): 1
    Type: Application
    Filed: March 6, 2003
    Publication date: October 30, 2003
    Inventors: Yasutaka Ishii, Tatsuya Nakano
  • Publication number: 20030171590
    Abstract: The present invention discloses processes for preparing piperidine derivative compounds of the formulae: 1
    Type: Application
    Filed: August 5, 2002
    Publication date: September 11, 2003
    Inventors: Thomas E. D'Ambra, Garry M. Pilling
  • Patent number: 6613907
    Abstract: The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is —COOH or —COOR4; R4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy. This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB: wherein R3 is —CH3 and R1, R2, A, B, and D are defined above In the presence of a microorganism under conditions effective to produce the product compound.
    Type: Grant
    Filed: January 4, 2001
    Date of Patent: September 2, 2003
    Assignee: AMR Technology, Inc.
    Inventors: Peter C. Michels, Eric L. Zirbes
  • Patent number: 6605630
    Abstract: The invention concerns a compound of the formula (I): wherein, for example: T is of the formula (IA), (IB), or (IC); R1 is of the formula —NHC(═O)Rb wherein Rb is (1-4C)alkyl; R2 and R3 are hydrogen or fluoro; >A—B— is >C═CH— (but not when T is (IA)) or >CH—CH2—; wherein when T is of the formula (IA) or (IB); R6 is, for example, (1-4C)alkyl; R5 is hydrogen, R10CO—, R10SO2— or R10CS— wherein R10 is, for example, optionally substituted phenyl, or (1-10C)alkyl, or when T is of the formula (IA), (IB); or (IC): R5 and R6 are linked to give a 5- or 6-membered ring which is fused to the ring shown in (IA), (IB), or (IC) so as to give an optionally substituted bicyclic ring; and pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them, and their use as antibacterial agents.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: August 12, 2003
    Assignee: Syngenta Limited
    Inventor: Michael Barry Gravestock
  • Publication number: 20030105329
    Abstract: The present invention relates to processes for preparing certain piperidine derivatives, including fexofenadine (F), the active ingredient in the non-sedating antihistamine sold in the U.S. under the designation “Allegra®”. This invention also relates to novel synthetic intermediates useful in the processes of the present invention.
    Type: Application
    Filed: June 11, 2002
    Publication date: June 5, 2003
    Inventors: Collin Schroeder, Ryan Huddleston, Richard Charles
  • Publication number: 20030087932
    Abstract: The present invention is directed to sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT2A antagonist (+)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and a processes for its preparation and its use in the treatment for a number of disease states.
    Type: Application
    Filed: July 22, 2002
    Publication date: May 8, 2003
    Inventors: Ronald C. Bernotas, Paul W. Brown, Gary T. Emmons, Chi-Hsin R. King
  • Publication number: 20030065186
    Abstract: This invention relates to novel substituted piperidine derivatives. More particularly, this invention relates to substituted phenyl 4-substituted-piperidinoalkanol derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
    Type: Application
    Filed: October 3, 2002
    Publication date: April 3, 2003
    Inventors: Kah Hiing Ling, Paul Wayne Brown, Robert M. Strom, Richard A. Wolf
  • Patent number: 6465490
    Abstract: The present invention is directed to sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester a metabolite of the 5HT2A antagonist (+)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and a processes for its preparation and its use in the treatment for a number of disease states.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: October 15, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Ronald Charles Bernotas, Paul Wayne Brown, Gary Thomas Emmons, Chi-Hsin Richard King
  • Patent number: 6407119
    Abstract: This invention relates to novel piperidine derivatives of formula (I) and a process for the preparation thereof. wherein R1 is H or C1-C6alkyl wherein the C1-C6alkyl moiety is straight or branched; R2 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; or stereoisomers or pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: June 18, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Timothy A. Ayers, Paul W. Brown
  • Patent number: 6358977
    Abstract: Disclosed is the use of a compound with Formula (I) wherein n is 2, 3, or 4, and R1, R2, R3, and R4 are each independently hydrogen, C1-6 alkyl, halogen, trifluoromethyl, hydroxy, C1-6 alkoxy or amino, or an optical isomer or a pharmaceutically acceptable salt thereof for the production of a pharmaceutical composition for treatment of a neurodevelopmental disorder. Also a method for treatment of neurodevelopmental disorders wherein a therapeutically effective amount of said compound is administered to a patient is disclosed.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: March 19, 2002
    Assignee: A. Carlsson Research AB
    Inventor: Maria Carlsson
  • Publication number: 20020016467
    Abstract: This invention relates to novel substituted piperidine derivatives. More particularly, this invention relates to substituted phenyl 4-substituted-piperidinoalkanol derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
    Type: Application
    Filed: October 2, 2001
    Publication date: February 7, 2002
    Inventors: Kah Hiing Ling, Paul Wayne Brown, Robert M. Strom, Richard A. Wolf
  • Patent number: 6207681
    Abstract: A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (R)-trihexyphenidyl. The method comprises administering a therapeutically effective amount of enantiomerically enriched (R)-trihexyphenidyl, or a pharmaceutically acceptable salt thereof, substantially free of the (S)-trihexyphenidyl enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (R)-trihexyphenidyl, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.
    Type: Grant
    Filed: December 29, 1998
    Date of Patent: March 27, 2001
    Assignee: Sepracor Inc.
    Inventors: Vincent L. Fabiano, John R. McCullough
  • Patent number: 6207835
    Abstract: Arylmetal compounds are prepared by deprotonation of aromatics which have a hydrogen atom in the ortho position relative to a halogen atom or a trifluoromethoxy group, using a suitable base or by halogen-metal exchange of haloaromatics using a suitable metalating reagent. The arylmetal compounds are prepared in a continuous-flow reactor. The arylmetal compound can be further reacted with an electrophilic reagent.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: March 27, 2001
    Assignee: Merck KGaA
    Inventors: Volker Reiffenrath, Hans Christian Stiasny
  • Patent number: 6165944
    Abstract: 4-(3-Heterocyclyl-1-benzoyl)pyrazoles of the formula I ##STR1## where: R.sup.1 and R.sup.3 are each hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, N-alkylaminosulfonyl, N,N-dialkyl)aminosulfonyl, N-alkylsulfonylamino, N-haloalkylsulfonylamino, N-alkyl-N-alkylsulfonylamino or N-alkyl-N-haloalkylsulfonylamino;R.sup.2 is a 5- or 6-membered heterocyclyl radical with or without substitution which comprises 1 to 4 identical or different hetero atoms from the following group: oxygen, sulfur or nitrogen;R.sup.4 is hydrogen, halogen or alkyl;R.sup.5 is substituted pyrazole which is attached in position 4;and agriculturally useful salts thereof; processes for preparing the 4-(3-heterocyclyl-1-benzoyl)pyrazoles; compositions comprising them; and the use of these derivatives or these compositions comprising them for controlling undesirable plants.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: December 26, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang von Deyn, Regina Luise Hill, Ernst Baumann, Stefan Engel, Guido Mayer, Joachim Rheinheimer, Matthias Witschel, Ulf Misslitz, Oliver Wagner, Martina Otten, Helmut Walter, Karl-Otto Westphalen
  • Patent number: 6133259
    Abstract: Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: October 17, 2000
    Assignee: University of Pittsburgh
    Inventors: William E. Klunk, Jay W. Pettegrew, Chester A. Mathis, Jr.
  • Patent number: 6004980
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: December 21, 1999
    Assignee: Merrell Pharmaceuticals, Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay
  • Patent number: 5990127
    Abstract: The invention relates to the preparation of the compound 4-(4-(4-(hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-.alpha.,.alpha.-d imethylphenylacetic acid and its phosphorylated derivatives. These compounds can be prepared from .alpha.-(p-tert-butylphenyl)-4-(.alpha.-hydroxy-.alpha.-phenylbenzyl)-1-pi peridinylbutanol with the aid of fungi of the genus Cunninghamella or Absidia. The compounds according to the present invention can be used as pharmaceuticals for the treatment of allergic disorders, allergic rhinitis or asthma. Compounds of the formula II in which R.sup.1 is --CH.sub.2 --O--P(O)(OH).sub.2 and R.sup.2 is --OH; R.sup.1 is --CH.sub.3 and R.sup.2 is --O--P(O)(OH).sub.2 ; orR.sup.1 is --COOH and R.sup.2 is --O--P(O)(OH).sub.2 are produced by the process according to the present invention and are suitable as pharmaceuticals with antihistamine action.
    Type: Grant
    Filed: March 9, 1998
    Date of Patent: November 23, 1999
    Assignee: Hoechst Marion Roussel Deutschland GmbH
    Inventors: Johannes Meiwes, Manfred Worm
  • Patent number: 5981528
    Abstract: The invention concerns a compound of formula (I): ##STR1## wherein R.sup.1 -R.sup.6, A, B, and D have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising such a compound or salt, and methods of treating a bacterial infection by administering such a compound or salt.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: November 9, 1999
    Assignee: Zeneca Limited
    Inventor: Michael Barry Gravestock
  • Patent number: 5777125
    Abstract: A process for the preparation of tertiary diphenyl carbinols containing a primary or secondary amine substituent on the aliphatic moiety attached to the carbinol function which consists in contacting a Grignard phenyl reagent with an aminoacid wherein the mobile protons are not masked in an aprotic inert organic solvent or a mixture thereof at a temperature between 20.degree. C. and the boiling temperature by the reaction mixture.The reaction products are useful as active ingredients of medicaments and intermediates for the manufacture thereof.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: July 7, 1998
    Assignee: Gruppo Lepetit SpA
    Inventor: Elvio Bellasio
  • Patent number: 5721249
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
  • Patent number: 5700812
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 23, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay
  • Patent number: 5700813
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 23, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay
  • Patent number: 5683998
    Abstract: Novel tricyclic triazolo derivatives and pharmaceutically acceptable salts thereof, which are useful as anti-inflammation agents, anti-allergy agents or anti-PAF agents as well as processes for producing the same are disclosed. The triazolo derivatives of the present invention are represented by the formula (I): ##STR1## ?wherein R.sup.1 represents hydrogen, lower alkyl or C.sub.3 -C.sub.5 cycloalkyl; R.sup.2 and R.sup.3 respectively represent hydrogen, lower alkyl, lower alkoxy or halogen; W represents C.dbd.O or CR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 respectively represents hydrogen or lower alkyl); A represents C.sub.1 -C.sub.5 straight or branched saturated or unsaturated alkylene which may contain one or more hetero atoms; l represents 0 to 2, n represents 1 to 3, . . . represents single bond or double bond; Y represents N or C; Z represents C(B)Ar.sup.1 Ar.sup.2 (wherein B represents hydrogen, hydroxy or methoxy, Ar.sup.1 and Ar.sup.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: November 4, 1997
    Assignee: Toray Industries, Inc.
    Inventors: Katsuhiro Shibayama, Tetsuya Makino, Takayuki Imaoka, Tetsuya Katou, Masayuki Kaneko
  • Patent number: 5675009
    Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: October 7, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Chi-Hsin Richard King, Michele A. Kaminski
  • Patent number: 5663353
    Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: September 2, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Chi-Hsin Richard King, Michele A. Kaminski