Process Of Forming Partially Hydrogenated Pyridine Ring Patents (Class 546/249)
  • Patent number: 10626123
    Abstract: The present invention relates to a process for synthesis of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to obtain the intermediate dimethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-5 dicarboxylate or the intermediate diethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: April 21, 2020
    Assignee: H. Lundbeck A/S
    Inventors: Carla De Faveri, Florian Anton Martin Huber
  • Patent number: 9388338
    Abstract: Liquid crystal mixture comprising one or several compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, M1, M2, X, A, and m are defined herein.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: July 12, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ji Li, Toshiaki Nonaka, Ayako Ogawa, Hans-Rolf Dübal, Barbara Hornung, Wolfgang Schmidt, Rainer Wingen
  • Patent number: 9260662
    Abstract: Liquid crystal mixture comprising one or several compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, M1, M2, X, A, and m are defined herein.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: February 16, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ji Li, Toshiaki Nonaka, Ayako Ogawa, Hans-Rolf Dübal, Barbara Hornung, Wolfgang Schmidt, Rainer Wingen
  • Patent number: 9018234
    Abstract: The present invention relates to novel, fluoro-substituted 2-aryl-3,5-dicyano-4-(1H-indazol-5-yl)-6-methyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly Cancer and other proliferative disorders.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: April 28, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Alexandros Vakalopoulos, Martin Michels, Katja Zimmermann, Nicole Teusch, Mario Lobell, Karen Engel
  • Patent number: 8957254
    Abstract: Process for synthesizing a chemical, in particular an agriculturally or pharmaceutically active compound, including: a first step comprising reacting a carboxylic acid halide with a vinyl ether to prepare a halogenated precursor of an alkenone; a second step comprising eliminating hydrogen halide from such precursor to form an alkenone, preferably by thermolysis under specific conditions; and a third step which uses the formed alkenone as a building block to synthesize the chemical. First step may be done in a liquid reaction medium comprising an alkenone or a halogenated alkenone precursor, or in a liquid reaction medium in turbulent state, specifically by creation of gas bubbles of the carboxylic acid halide herein. Second step may include a flash thermolysis, vacuum thermolysis, thermolysis under stripping with inert gas, and/or a thermolysis at a temperature from >90° C. to 120° C. Third step preferably comprises reacting the alkenone with a nitrogen-containing compound.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: February 17, 2015
    Assignee: Solvay SA
    Inventors: Max Braun, Stefan Palsherm, Uta Claassen, Alain Lambert
  • Patent number: 8864848
    Abstract: The invention relates to agents for coloring keratinic fibers, in particular human hair, including in a cosmetic carrier at least one compound of the formula (I). The structures the of the general formula (I) have a heterocycle A which bears a quaternary nitrogen atom and thus a positive charge. The invention furthermore relates to the use of these novel azo dyes in agents for coloring hair and to the dyes themselves.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: October 21, 2014
    Assignee: Henkel AG & Co. KGAA
    Inventors: Wibke Gross, Ralph Nemitz, Melanie Moch
  • Patent number: 8864849
    Abstract: The present specification provides for an agent for coloring keratinic fibers. The agent includes, a cosmetic carrier, a compound of formula (I), R1 and R2 independently of one another denote hydrogen, a C1-C6 alkyl group, a C2-C6 alkenyl group, a hydroxyl group, a halogen, a C1-C6 alkoxy group, an amino group, a nitro group, an acetyl amino group, or a sulfonamide group; or when in ortho-position to one another, form a 5- or 6-membered, saturated or unsaturated ring, which optionally include further heteroatoms.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: October 21, 2014
    Assignee: Henkel AG & Co. KGaA
    Inventors: Wibke Gross, Ralph Nemitz, Melanie Moch, Astrid Kroos, Antje Gebert
  • Patent number: 8685114
    Abstract: The invention relates to a dyeing composition comprising a fluorescent disulphide dye and to a method of dyeing keratin materials, with a lightening effect, that employs said composition. It likewise relates to new fluorescent disulphide dyes and to their uses in the lightening of keratin materials. This composition allows a particularly persistent lightening effect to be obtained.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: April 1, 2014
    Assignee: L'Oreal
    Inventors: Nicolas Daubresse, Andrew Greaves, Henri Samain
  • Patent number: 8491669
    Abstract: The present invention relates to a cationic aminopyridine of general formula (I), acid-addition salts thereof and solvates thereof: in which: R1 is a linear or branched, saturated C1-C20 alkyl radical, substituted and/or interrupted with a cationic radical. The present invention is also directed towards a process for synthesizing this cationic aminopyridine, compositions, uses, hair dyeing processes and devices using this cationic aminopyridine.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: July 23, 2013
    Assignee: L'Oreal
    Inventor: Aziz Fadli
  • Publication number: 20130165649
    Abstract: Cls ruthenium complexes that can be used as catalysts are described. The complexes are generally square pyramidal in nature, having two anionic ligands X adjacent to each other. The complexes can be used as catalysts, for example in olefin metathesis reactions. Corresponding trans ruthenium complexes are also described, together with cationic complexes where one or both of the anionic ligands X are replaced by a non-co-ordinating anionic ligand.
    Type: Application
    Filed: March 21, 2011
    Publication date: June 27, 2013
    Inventor: Catherine Cazin
  • Patent number: 8431710
    Abstract: A process for the manufacture of a cyclic compound of formula (I) which comprises (a) adding an acid halide of formula R1—C(O)—X, to a vinyl ether of formula (II): CH2?CH—OR2, to produce an addition product, and (b) reacting the addition product with a compound of formula (III): Y-A-Z; wherein R1 is a halogenated alkyl group; wherein X is fluorine, chlorine, or bromine; wherein R2 is an alkyl group, an aralkyl group, or an aryl group; wherein Z and Y designate independently carbon or a heteroatom; and wherein A is a linking group between Z and Y comprising 0, 1, 2 or 3 atoms in the cycle.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: April 30, 2013
    Assignee: Solvay SA
    Inventor: Max Braun
  • Publication number: 20130053565
    Abstract: Described herein are methods for synthesizing substituted 3-piperidone compounds. Notably, substituted 3-piperidones can also be prepared in enantiopure form. The methods may allow for preparation of highly substituted piperidine cores. Also disclosed are 3-piperidone compounds and pharmaceutical compositions comprising the compounds.
    Type: Application
    Filed: August 29, 2012
    Publication date: February 28, 2013
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Janis Louie, Puneet Kumar
  • Publication number: 20130005773
    Abstract: The present invention relates to novel, fluoro-substituted 2-aryl-3,5-dicyano-4-(1H-indazol-5-yl)-6-methyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly Cancer and other proliferative disorders.
    Type: Application
    Filed: November 8, 2010
    Publication date: January 3, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Alexandros Vakalopoulos, Martin Michels, Katja Zimmermann, Nicole Teusch, Mario Lobell, Karen Engel
  • Publication number: 20120149735
    Abstract: The present invention relates to 1,4-dihydropyridine derivatives of the formula (I) and their uses in the treatment and/or prevention of diseases and disorders directly or indirectly associated with the modification (increase or decrease) of the activity of the cannabinoid receptor 2 (CB2).
    Type: Application
    Filed: May 19, 2010
    Publication date: June 14, 2012
    Applicants: CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE, UNIVERSITE LILLE 2 DROIT ET SANTE
    Inventors: Regis Millet, Jamal El Bakali, Philippe Chavatte, Nicolas Renault, Didier Lambert, Giulo Muccioli, Mathilde Body-Malapel, Pierre Desreumaux
  • Publication number: 20120100274
    Abstract: The present invention relates to a method for synthetizing a compound of the following formula (I): wherein R is a methyl or ethyl group, n is 1 or 2, and X is a CH2 or CD2 group, from a compound of the following formula (II): wherein R and n are as defined above, and also relates to a method for assaying the compounds of the formula (I) using a corresponding deuterated derivative as an internal reference, as well as to the use of ketal derivatives of compounds of the formula (I) as a stable precursor, in particular in a flavoring composition.
    Type: Application
    Filed: June 24, 2010
    Publication date: April 26, 2012
    Inventors: Alain Morere, Chantal Menut, Yusuf Ziya Gunata, Abdelhamid Agrebi
  • Patent number: 8012220
    Abstract: The present disclosure relates to monocationic monochromophoric compounds of formula (I) and (II) and dyeing compositions and multicompartment devices comprising monocationic monochromophoric compounds of formula (I) and (II). The disclosure also relates to methods for preparing monocationic monochromophoric compounds of formula (I) and (II), and also to methods for dyeing comprising applying monocationic monochromophoric compounds of formula (I) and (II) to keratin fibers.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: September 6, 2011
    Assignee: L'Oreal S.A.
    Inventors: Hervé David, Nadège Murguet, Andrew Greaves
  • Publication number: 20110178297
    Abstract: A process for the manufacture of a cyclic compound of formula (I) which comprises (a) adding an acid halide of formula R1—C (O)—X, to a vinyl ether of formula (II): CH2?CH—OR2, to produce an addition product, and (b) reacting the addition product with a compound of formula (III): Y-A-Z; wherein R1 is a halogenated alkyl group; wherein X is fluorine, chlorine, or bromine; wherein R2 is an alkyl group, an aralkyl group, or an aryl group; wherein Z and Y designate independently carbon or a heteroatom; and wherein A is a linking group between Z and Y comprising 0, 1, 2 or 3 atoms in the cycle.
    Type: Application
    Filed: September 25, 2009
    Publication date: July 21, 2011
    Applicant: SOLVAY SA
    Inventor: Max Braun
  • Publication number: 20110166349
    Abstract: Methods are provided for the catalytic hydroamination of compounds having an alkyne or allene functional group, in which the compound is contacted with ammonia or an amine in the presence of a catalytic amount of a gold complex under conditions sufficient for hydroamination to occur.
    Type: Application
    Filed: May 8, 2009
    Publication date: July 7, 2011
    Applicant: The Regents of the University of California
    Inventors: Guy Bertrand, Vincent Lavallo, Guido D. Frey, Bruno Donnadieu, Michele Soleil-Havoup
  • Publication number: 20110152324
    Abstract: A compound of formula: wherein Ar1, Ar2, V, X, R3, R4, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Cyclo(hetero)alkenyl Compound”); compositions comprising an effective amount of a Cyclo(hetero)alkenyl Compound; and methods for treating or preventing, e.g., pain, UI, an ulcer, IBD, or IBS in an animal, comprising administering to an animal in need thereof an effective amount of a Cyclo(hetero)alkenyl Compound are disclosed herein.
    Type: Application
    Filed: February 16, 2010
    Publication date: June 23, 2011
    Applicant: Purdue Pharma L.P.
    Inventors: Donald J. Kyle, Qun Sun, Laykea Tafesse
  • Publication number: 20110130562
    Abstract: In one embodiment, the present application discloses mixtures comprising (a) water in an amount of at least 1% wt/wt of the mixture; (b) a transition metal catalyst; and (c) one or more solubilizing agents; and methods for using such mixtures for performing transition metal mediated bond formation reactions.
    Type: Application
    Filed: December 1, 2010
    Publication date: June 2, 2011
    Inventor: Volker Berl
  • Publication number: 20110065915
    Abstract: The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.
    Type: Application
    Filed: January 23, 2009
    Publication date: March 17, 2011
    Applicant: TRUSTEES OF BOSTON COILEGE
    Inventors: Steven J. Malcolmson, Amir H. Hoveyda, Simon J. Meek, Richard R. Schrock
  • Patent number: 7820825
    Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: October 26, 2010
    Assignee: Wyeth LLC
    Inventors: Derek Cecil Cole, Magda Asselin, Joseph Raymond Stock, Albert Jean Robichaud, Ji-In Kim, William Ronald Solvibile, Jonathan Laird Gross
  • Publication number: 20100113722
    Abstract: Sulfur chelated ruthenium compounds represented by the following formula: wherein M indicates the ruthenium metal bound to a benzylidene carbon; R represents C1-C7 alkyl group or optionally substituted aryl; X1 and X2 each independently represent halogen; Y1 and Y2 each independently denote unsubstituted or alkyl-substituted phenyl; and Z independently represents hydrogen, electron withdrawing or electron donating substituent, with m being an integer from 1 to 4, and processes and compositions related thereto.
    Type: Application
    Filed: October 30, 2009
    Publication date: May 6, 2010
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: N. Gabriel LEMCOFF, Amos BEN-ASULY
  • Publication number: 20090318592
    Abstract: The present invention relates to novel processes for the preparation of a sterically hindered amine ether by reacting a corresponding sterically hindered amine oxide with a ketone or an aldehyde with at least one reactive H in the presence of a peroxydisulphate. Products obtained by this process may be hydrogenated. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers.
    Type: Application
    Filed: October 2, 2006
    Publication date: December 24, 2009
    Applicant: CIBA CORPORATION
    Inventors: Markus Frey, Valérie Brönnimann
  • Publication number: 20090203860
    Abstract: One embodiment of the invention provides polyisobutylene (PIB) oligomers that are end-functionalized with ruthenium (Ru) catalysts. Such nonpolar catalysts can be dissolved in nonpolar solvents such as heptane, or any other nonpolar solvent that is otherwise not latently biphasic (i.e., if two or more solvent components are present, they remain miscible with each other throughout the entire reaction process, from the addition of substrate through to the removal of product). Substrate that is dissolved in the nonpolar solvent with the catalyst is converted into product. The lower solubility of the product in the nonpolar solvent renders it easily removable, either by extraction with a more polar solvent or by applying physical means in cases where the product precipitates from the nonpolar solvent. In this manner the catalysts are recycled; since the catalysts remain in the nonpolar solvent, a new reaction can be initiated simply by dissolving fresh substrate into the nonpolar solvent.
    Type: Application
    Filed: October 1, 2008
    Publication date: August 13, 2009
    Inventors: David E. Bergbreiter, Hassan S. Bazzi, Chayanant Hongfa
  • Patent number: 7569079
    Abstract: The present disclosure relates to polycationic monochromophoric hydrazone compounds of following formula (I): wherein W1 is a heteroaromatic radical comprising 5 or 6 ring members, optionally condensed with an aromatic ring comprising 6 ring members, comprising a quaternized nitrogen atom and optionally another heteroatom which may or may not be identical to nitrogen; X, which may or may not be identical, is a nitrogen atom or a CR2 group; Z is a cationic group comprising at least one quaternized nitrogen atom. 1The present disclosure also relates to a composition for dyeing human keratin fibers comprising the polycationic compounds disclosed herein, and to a dyeing process using the composition of the present disclosure, and ever further to multicompartment device.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: August 4, 2009
    Assignee: L'Oreal S.A.
    Inventors: Hervé David, Nadège Murguet
  • Patent number: 7528260
    Abstract: A method is disclosed for preparing compounds of Formula 1 by combining compounds of Formulae 2 and 3 and a sulfonyl chloride. Also disclosed are compounds of Formula 3, which are useful as starting materials for this method.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: May 5, 2009
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rafael Shapiro, Eric de Guyon Taylor, William T. Zimmerman
  • Publication number: 20090005569
    Abstract: 4-Trifluoromethyl-2(1H)-pyridinone is prepared from an alkyl vinyl ether and trifluoroacetyl chloride in a four step process.
    Type: Application
    Filed: June 27, 2008
    Publication date: January 1, 2009
    Applicant: Dow AgroSciences LLS
    Inventors: Douglas C. Bland, John Davies
  • Patent number: 7468437
    Abstract: The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, depression, and anxiety.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: December 23, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Robert J. DeVita, Peter Lin, Sander G. Mills, Jonathan R. Young
  • Patent number: 7438728
    Abstract: Disclosed herein are dissymmetrical cationic diazo compounds comprising a 2-pyridinium group and a cationic or non-cationic linker. Also disclosed herein are dyeing compositions comprising such compounds as a direct dye in a medium appropriate for the dyeing of keratin fibers, a method for coloring keratin fibers comprising contacting the keratin fibers with such dyeing compositions, and a device comprising a plurality of compartments.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: October 21, 2008
    Assignee: L'Oreal S.A.
    Inventors: Hervé David, Andrew Greaves, Nicolas Daubresse
  • Patent number: 7439366
    Abstract: The present invention relates to a phenacylamine derivative of the formula (I) or a salt thereof: wherein A is alkyl, cycloalkyl, phenyl which may be substituted by Y, pyridyl which may be substituted by Y, or pyrazolyl which may be substituted by Y, R1 and R2 are each alkyl, or R1 and R2 may together form a 3- to 6-membered saturated carbocycle, R3 is hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl or COR4, X is halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkenyloxy, haloalkenyloxy, alkynyloxy, haloalkynyloxy, alkylthio, haloalkylthio, alkenylthio, haloalkenylthio, alkynylthio, haloalkynylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, dialkylaminosulfonyl, nitro, cyano, phenyl which may be substituted by Y, phenoxy which may be substituted by Y, benzyloxy which may be substituted by Y, or pyridyloxy which may be substituted by Y, and n is an integer of from 0 to 5.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: October 21, 2008
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Yuji Nakamura, Masayuki Morita, Kenji Izakura
  • Patent number: 7429278
    Abstract: The present disclosure is directed to a family of N-alkylheteroaryl secondary para-phenylenediamines, to their preparation, and to a cosmetic composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising, in a suitable dyeing medium, at least one N-alkylheteroaryl secondary para-phenylenediamine. Further disclosed herein is a process of dyeing keratin fibers, a ready-to-use composition, and a kit comprising at least two compartments.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: September 30, 2008
    Assignee: L'Oréal
    Inventors: Stéphane Sabelle, Eric Metais
  • Patent number: 7410506
    Abstract: The present disclosure relates to a novel family of dicationic bis-hydrazone compounds that may be used as direct dyes, and to a dye composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising, in a suitable dyeing medium, at least one such compound. Also disclosed are dyeing processes implementing this composition and uses thereof.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: August 12, 2008
    Assignee: L'Oreal S.A.
    Inventors: Hervé David, Andrew Greaves, Leïla Hercouet, Alain Lagrange
  • Patent number: 7407516
    Abstract: The present disclosure relates to a novel dyeing composition for dyeing human keratinous fibers, such as hair, comprising at least one dicationic diazo dye of formula (I): [W1—N?N—W2—W3—(W4—W5)p-]2-L ??Formula (I) as well as the process for dyeing hair using same. Certain compounds of formula (I) are also disclosed herein.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: August 5, 2008
    Assignee: L'Oreal, S.A.
    Inventor: Laurent Vidal
  • Publication number: 20080132705
    Abstract: 2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield by cyclization and thioalkylation.
    Type: Application
    Filed: February 9, 2007
    Publication date: June 5, 2008
    Inventors: Stephen T. Heller, Ronald Ross, Nicholas M. Irvine, James M. Renga, Mark M. Zettler, Kim E. Erndt
  • Patent number: 7332512
    Abstract: The present invention relates to novel halonitrobutadienes, to processes for their preparation and to their use for controlling animal pests.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: February 19, 2008
    Assignee: Bayer CropScience AG
    Inventors: Reiner Fischer, Peter Jeschke, Angelika Lubos-Erdelen, legal representative, Peter Lösel, Udo Reckmann, Dieter Kaufmann, Viktor Zapolskil, Christoph Erdelen
  • Patent number: 7329288
    Abstract: The present disclosure relates to a novel family of N-heteroaryl secondary para-phenylenediamines, to their preparation, to their use for dyeing the hair and to a dye composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising, in a suitable dyeing medium, at least one heteroaryl secondary para-phenylenediamine. The disclosure also relates to the process using this composition, to its use and to the multi-compartment device and dyeing “kit”.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: February 12, 2008
    Assignee: L'Oreal S.A.
    Inventors: Stéphane Sabelle, Eric Metais
  • Patent number: 7319084
    Abstract: Catalyst compositions useful for the polymerization or oligomerization of olefins are disclosed. Certain of the catalyst compositions comprise N-pyrrolyl substituted nitrogen donors. Also disclosed are processes for the polymerization or oligomerization of olefins using the catalyst compositions.
    Type: Grant
    Filed: March 21, 2006
    Date of Patent: January 15, 2008
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Leslie Shane Moody, Peter Borden Mackenzie, Christopher Moore Killian, Gino Georges Lavoie, James Allen Ponasik, Jr., Anthony Gerard Martin Barrett, Thomas William Smith, Jason Clay Pearson
  • Patent number: 7288122
    Abstract: The present disclosure relates to cationic diazo dye compounds of formula (I): Dye1-LK-Dye2, ??(I) dye compositions comprising the direct dye compounds, and also to a process for dyeing keratin fibers using this composition and a multi-compartment kit.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: October 30, 2007
    Assignee: L'Oreal S.A.
    Inventors: Andrew Greaves, Hervé David
  • Patent number: 7285138
    Abstract: The present disclosure relates to a cationic diazo compound of formula (I): Dye1-LK-Dye2 wherein Dye1 and Dye2 are such that the compound of formula (I) is not symmetrical, and are chosen from: The disclosure also relates to dye compositions comprising compounds of formula (I) as direct dye, and further relates to a process for dyeing keratin fibers using the compositions disclosed herein and also to a multi-compartment device.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: October 23, 2007
    Assignee: L'Oreal, S.A.
    Inventors: Andrew Greaves, Hervé David
  • Patent number: 7282069
    Abstract: The present disclosure relates to cationic diazo compounds chosen from those of formula (I) and the acid addition salts thereof: Dye1-LK-Dye2 (I); and to dye compositions comprising the the compounds as direct dye, and also to a process for dyeing keratin fibers using this composition and a multi-compartment device.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: October 16, 2007
    Assignee: L'Oreal S.A.
    Inventors: Andrew Greaves, Hervé David
  • Patent number: 7238211
    Abstract: The invention relates to a dye composition that is useful for dyeing keratin fibers, containing at least one oxidation base and at least one coupler of the 6-alkoxy-2,3-diaminopyridine type in which the amino radical in position 2 is a disubstituted amino radical, to the use of this composition for dyeing keratin fibers and to the dyeing process using this composition. The invention also relates to novel 6-alkoxy-2,3-diaminopyridine compounds that are useful as couplers.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: July 3, 2007
    Assignee: L'Oreal S.A.
    Inventors: Laurent Vidal, Aziz Fadli
  • Patent number: 7204857
    Abstract: The present invention relates to the use, for dyeing keratin fibres, of at least one specific compound containing active methylene and of at least one compound chosen from an aldehyde, a ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative, which makes it possible to obtain, by reaction without an oxidizing agent, a coloration of the said keratin fibres.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: April 17, 2007
    Assignee: L'Oreal S.A.
    Inventors: Hervé Andrean, Alain Lagrange
  • Patent number: 7198648
    Abstract: The invention relates to a method for dyeing keratin fibers, especially human hair. The inventive method comprises the following steps: optionally applying a pretreatment agent M1 to the fiber, using a dye M2 on the fiber which is optionally mixed immediately before application to the fiber from a component M2a, containing at least one oxidative dye pre-product of the developer type and/or an indole and/or indole derivative and a component M2b, containing an oxidative dye and/or an enzyme. If desired, a third agent M3 is added to the individual agents M2a or M2b before mixing them or to the mixture M2, and said dye M2 is rinsed from the fiber after a period of 5–10 minutes. At least one of the agents M1, M2a, M2b or M3 contains a compound from the vitamin B6 group. The invention further relates to hair pretreatment agents, to agents for dyeing keratin fibers, to their packing in corresponding kits and to the use thereof.
    Type: Grant
    Filed: June 9, 2001
    Date of Patent: April 3, 2007
    Assignee: Henkel Kommanditgesellschaft Auf Aktien (Henkel KGAA)
    Inventors: Frank Naumann, Astrid Kleen, Horst Hoeffkes, Bernd Meinigke
  • Patent number: 7192963
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3.
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: March 20, 2007
    Assignee: Pfizer Inc
    Inventors: Todd A. Blumenkopf, Mark E. Flanagan, Michael J. Munchhof
  • Patent number: 7151181
    Abstract: Methods are provided for improving production of 3,5-diethyl-1,2-dihydro-1-phenyl-2-propylpyridine (DHP). In one illustrative embodiment, the methods involve controlling the rate of reaction and temperature of the reaction during formation of DHP. In another illustrative embodiment, the methods involve neutralizing the acid catalyst subsequent to DHP formation.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: December 19, 2006
    Assignee: Reilly Industries, Inc.
    Inventors: Martin Grendze, Ramiah Murugan, L. Mark Huckstep, Charles R. Hopper
  • Patent number: 7141560
    Abstract: The present invention relates to alanine 2,6-dialkoxyphenyl ester derivatives having the general formula I The invention also relates to pharmaceutical compositions comprising said derivatives, and to the use of these alanine 2,6-dialkoxyphenyl ester derivatives as hypnotics for the induction and maintenance of general anaesthesia.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: November 28, 2006
    Assignee: Akzo Nobel N.V.
    Inventors: Niall Morton Hamilton, David Jonathan Bennett
  • Patent number: 7141079
    Abstract: The invention concerns an oxidation dyeing composition for keratinous fibers, and in particular human keratinous fibers such as hair comprising, in a medium suited for dyeing: as first coupling agent at least a 3,5-diaminopyridine derivative suitably selected; and as second coupling agent at least a meta-phenylenediamine, and/or one of its addition salts with an acid; and at least an oxidation base such as para-phenylenediamine and/or one of its addition salts with an acid. The invention also concerns the dyeing method using said composition.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: November 28, 2006
    Assignee: L′Oreal
    Inventor: Marie-Pascale Audousset
  • Patent number: 7141078
    Abstract: The invention concerns an oxidation dyeing composition for keratinous fibers, and in particular human keratinous fibers such as hair, comprising, in a medium suited for dyeing, (a) as first coupling agent at least a 3,5-diamino-pyridine derivative suitably selected; (b) and as second coupling agent at least resorcin (1,3-dihydrobenzene) and/or one of its addition salts with an acid; (c) and as third coupling agent at least an oxidation base such as para-phenylenediamine and/or one of its addition salts with an acid. The invention also concerns the dyeing method using said composition.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: November 28, 2006
    Assignee: L′Oreal
    Inventor: Marie-Pascale Audousset
  • Patent number: 7101406
    Abstract: The subject of the present application is a dyeing composition for dyeing keratinous fibers, in particular human keratinous fibres such as hair, comprising, in an appropriate dyeing medium, at least one cationic tertiary para-phenylenediamine containing a pyrrolidine ring, and at least one cationic direct dye comprising at least one heterocyclic group. The subject of the invention is also the dyeing method using this composition and the corresponding devices.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: September 5, 2006
    Assignee: L'Oreal
    Inventors: Jean Cotteret, Alain Lagrange