Patent number: 6465486
Abstract: Certain imidazo pyridines/quinolines of the formula:
where
n is 0, 1, 2;
X is independently selected from the group consisting of C1-4alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4alkoxy, —SO2NH2, nitro, and two adjacent X may be fused to form the moiety:
whereby a saturated, partially unsaturated or aromatic six-membered fused ring is formed;
Y is independently selected from the group consisting of hydrogen, hydroxy, C1-4alkyl, C1-4alkoxy, trifluoromethyl and phenyl; and
Z is independently selected from the group consisting of hydroxy, C1-4alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4alkoxy, —SO2NH2 and nitro;
are &agr;2-adrenoceptor modulators which are useful in the treatment of hypertension, glaucoma, sexual dysfunction, depression, attention deficit hyperactivity disorder, Parkinsonism, the need for anesthesia, cardiac arrythmia or the need for analgesia.
Type:
Grant
Filed:
March 10, 2000
Date of Patent:
October 15, 2002
Assignee:
Ortho-McNeil Pharmaceutical, Inc.
Inventors:
Ellen W. Baxter, Robert E. Boyd, John R. Carson, Michele C. Jetter, Allen B. Reitz
Patent number: 6302837
Abstract: A compound selected from those of formula (I):
wherein:
X represents oxygen, sulphur, or NR3 wherein R3 is as defined in the description,
Y represents oxygen, sulphur, NR3, or may represent single bond in certain cases,
T represents nitrogen, carbon, or CH,
A represents single bond, alkylene, arylene, cycloalkylene, heterocycloalkylene, heteroarylene, or —SO2—R4— wherein R4 is as defined in the description,
W represents hydroxy, alkoxy, aryloxy, arylalkoxy, cycloalkyloxy, heterocycloalkyloxy or heteroaryloxy, or hydroxyamino,
U1 represents hetero, or alkylene wherein one or more of carbon may optionally be replaced by one or more hetero atoms,
V1 represents arylene, heteroarylene,or heterocycloalkylene,
U2 represents single bond, hetero or alkylene wherein one or more carbon may optionally be replaced by one or more hetero atoms,
V2 represents aryl, heteroaryl, or heterocycloalkyl,
Ra, Rb, Rc, which may be identical or different, each independently of the others r
Type:
Grant
Filed:
October 13, 2000
Date of Patent:
October 16, 2001
Assignee:
Adir et Compagnie
Inventors:
Guillaume De Nanteuil, Christine Lila, Tony Verbeuren, Alain Rupin