Chalcogen Attached Directly To The Additional Hetero Ring By Nonionic Bonding Patents (Class 546/284.4)
  • Patent number: 10875868
    Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are. disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: December 29, 2020
    Assignee: VERNALIS (R&D) LIMITED
    Inventors: Samantha Jane Bamford, Roger John Gillespie, Richard Simon Todd
  • Patent number: 9388169
    Abstract: Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: July 12, 2016
    Assignee: Zhengzho University
    Inventors: Guifu Dai, Songlin Zhu, Yanan Wang, Jian Wu, Dan Zhao, Di Wu, Huanfei Liu, Haiwei Xu, Mengjiao Liu, Jing Zhao, Wei Han, Zhenwei Wu, Hang Wang, Hongmin Liu
  • Patent number: 9265767
    Abstract: 1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Among the disorders which may be treated are neurological, neurodegenerative and psychiatric disorders including, but not to, those associated with cognitive deficits or schizophrenic symptoms.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: February 23, 2016
    Assignee: FORUM PHARMACEUTICALS INC.
    Inventors: Richard Chesworth, Amy Ripka, Gideon Shapiro
  • Publication number: 20150051403
    Abstract: Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.
    Type: Application
    Filed: February 5, 2013
    Publication date: February 19, 2015
    Applicant: ZHENGZHOU UNIVERSITY
    Inventors: Guifu Dai, Songlin Zhu, Yanan Wang, Jian Wu, Dan Zhao, Di Wu, Huanfei Liu, Haiwei Xu, Mengjiao Liu, Jing Zhao, Wei Han, Zhenwei Wu, Hang Wang, Hongmin Liu
  • Publication number: 20140371268
    Abstract: The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases, gastrointestinal diseases and respiratory diseases.
    Type: Application
    Filed: August 31, 2012
    Publication date: December 18, 2014
    Applicant: AMAKEM NV
    Inventors: Jo Alen, Sandro Boland, Arnaud Pierre Jean Bourin, Olivier Defert, Dirk Leysen
  • Publication number: 20140323502
    Abstract: The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.
    Type: Application
    Filed: February 13, 2014
    Publication date: October 30, 2014
    Inventors: Anton Franz Joseph Fliri, Randall James Gallaschun, Christopher John O'Donnell, Jacob Bradley Schwarz, Barbara Eileen Segelstein
  • Patent number: 8846125
    Abstract: The present invention relates to enaminocarbonyl compounds with the formula I. The present invention also relates to the use of compounds with the formula I for the modification of the taste of a product and/or preparation for oral administration.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: September 30, 2014
    Assignee: Instytut Chemii Organicznej, Polska Akademia Nauk
    Inventors: Piotr Krajewski, Agnieszka Woźniak
  • Patent number: 8815914
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: August 26, 2014
    Assignee: H. Lundbeck A/S
    Inventors: Anette Graven Sams, Jorgen Eskildsen, Ask Püschl
  • Publication number: 20140187555
    Abstract: The present invention relates to new phosphodiesterase inhibitors, more specifically soft PDE4 inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new soft PDE4 inhibitors compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including inflammatory diseases.
    Type: Application
    Filed: August 9, 2012
    Publication date: July 3, 2014
    Applicant: AMAKEM NV
    Inventors: Dirk Leysen, Olivier Defert, Sandro Boland
  • Patent number: 8765790
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: July 1, 2014
    Assignee: H. Lundbeck A/S
    Inventors: Jørgen Eskildsen, Anette Graven Sams, Ask Püschl
  • Patent number: 8680285
    Abstract: The present invention relates to a process for the preparation of enaminocarbonyl compounds of the formula (I) where compounds of the formula (II) are reacted in the presence of a Brønsted acid to give compounds of the formula (I), and A, R1 and Z are as defined in the description, and also corresponding starting compounds which are used in the process according to the invention.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: March 25, 2014
    Assignee: Bayer Cropscience AG
    Inventors: Norbert Lui, Jens-Dietmar Heinrich
  • Patent number: 8680286
    Abstract: The present invention relates to a process for preparing enaminocarbonyl compounds by reacting compounds of the formula (II) with compounds of the formula (III) in which the A, R1, R2 and Z radicals are each as defined in the description, in the presence of a Brønsted acid.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: March 25, 2014
    Assignee: Bayer Cropscience AG
    Inventors: Norbert Lui, Jens-Dietmar Heinrich
  • Patent number: 8653110
    Abstract: Disclosed are novel active compound combinations comprising at least one substituted enaminocarbonyl compound and azadirachtin, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids. Methods of controlling insects and acarids are also disclosed.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: February 18, 2014
    Assignee: Bayer CropScience AG
    Inventors: Michael Kilian, Margit Doth
  • Publication number: 20140044806
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Application
    Filed: October 16, 2013
    Publication date: February 13, 2014
    Applicant: H. Lundbeck A/S
    Inventors: Jørgen Eskildsen, Anette Graven Sams, Ask Püschl
  • Patent number: 8637550
    Abstract: Disclosed are compounds and compositions of the formula (I) as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula (I).
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: January 28, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Neil Alexander Farrow, Donghong Amy Gao, Alexander Heim-Riether, Sabine Schlyer, Lana Louise Smith Keenan, Steven John Taylor, Bernd Wellenzohn, Dieter Wiedenmayer, Zhaoming Xiong, Qiang Zhang
  • Publication number: 20140010897
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 9, 2014
    Inventors: Anette Graven Sams, Jorgen Eskildsen, Ask Püschl
  • Publication number: 20140010898
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 9, 2014
    Inventors: Jorgen Eskildsen, Anette Graven Sams, Ask Püschl
  • Publication number: 20130324412
    Abstract: N-Alkoxyamides of 4-aminopicolinic acids and 6-amino-4-pyrimidinecarboxylates are selective herbicides for corn, canola and sugar beet.
    Type: Application
    Filed: August 8, 2013
    Publication date: December 5, 2013
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Joseph D. Eckelbarger, Paul R. Schmitzer, Carla N. Yerkes, Timothy A. Boebel, Norbert M. Satchivi, Gregory T. Whiteker
  • Publication number: 20130303376
    Abstract: The invention relates to the use of at least one compound selected from the class of the enaminocarbonyl compounds for enhancing plants' intrinsic defences and/or for improving plant growth and/or for enhancing the resistance of plants to plant diseases which are caused by fungi, bacteria, viruses, MLOs (mycoplasma-like organisms) and/or RLOs (rickettsia-like organisms), and/or for enhancing the resistance of plants to abiotic stress factors.
    Type: Application
    Filed: July 19, 2013
    Publication date: November 14, 2013
    Inventors: Robert Velten, Peter Jeschke, Dirk Ebbinghaus, Wolfgang Thielert, Heike Hungenberg, Claudia Urlass
  • Patent number: 8563584
    Abstract: The present application relates to novel substituted enaminothiocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: October 22, 2013
    Assignee: Bayer CropScience AG
    Inventors: Robert Velten, Peter Jeschke, Eva-Maria Franken
  • Patent number: 8481534
    Abstract: 5- and 6-membered heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Also described is the treatment of neurological, neurodegenerative and psychiatric disorders including but not limited to those comprising cognitive deficits or schizophrenic symptoms.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: July 9, 2013
    Assignee: EnVivo Pharmaceuticals, Inc.
    Inventors: Amy Ripka, Gideon Shapiro, Richard Chesworth
  • Publication number: 20130172312
    Abstract: Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.
    Type: Application
    Filed: December 14, 2012
    Publication date: July 4, 2013
    Inventors: Bernd NOSSE, Martin FLECK, Niklas HEINE, Gerald Juergen ROTH
  • Publication number: 20130059731
    Abstract: The present invention relates to a novel solid form of 4-[[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one, to processes for its preparation and to its use in agrochemical preparations.
    Type: Application
    Filed: October 31, 2012
    Publication date: March 7, 2013
    Applicant: BAYER CROPSCIENCE AG
    Inventor: BAYER CROPSCIENCE AG
  • Publication number: 20130012530
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Application
    Filed: July 6, 2012
    Publication date: January 10, 2013
    Applicant: H. Lundbeck A/S
    Inventors: Jørgen Eskildsen, Anette Graven Sams, Ask Püschl
  • Patent number: 8344151
    Abstract: Process for the preparation of 4-aminobut-2-enolide compounds of the formula (I): comprising reaction of a 4-alkoxyfuran-2(5H)-one compound or 4-arylalkoxyfuran-2(5H)-one compound of the formula (II) with an amine of the formula (III) in which R1, R2 and A have the definitions given in the description, in the presence of a Brønstedt acid.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: January 1, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Norbert Lui, Jens-Dietmer Heinrich
  • Patent number: 8324253
    Abstract: The present invention relates to a defined crystalline modification of the compound of the formula (I), to processes for its preparation and to its use in agrochemical preparations.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: December 4, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Britta Olenik, Peter Jeschke, Robert Velten, Bernd Gallenkamp, Wolfgang Joerges, Ronald Vermeer, Leonardo Pitta
  • Patent number: 8314242
    Abstract: Process for the preparation of 4-aminobut-2-enolide compounds of the formula (I): comprising reaction of a 4-(methylamino)furan-2(5H)-one compound of the formula (II) with an amine of the formula (III) in which R1 and A have the definitions mentioned in the description, optionally in the presence of a Brønstedt acid.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: November 20, 2012
    Assignee: BayerCrop Science AG
    Inventors: Norbert Lui, Jens-Dietmar Heinrich
  • Publication number: 20120283294
    Abstract: The invention relates to a new co-crystal of 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoroethyl)amino} furan-2(5H)-one with benzoic acid, to processes for the preparation thereof and use thereof.
    Type: Application
    Filed: October 26, 2010
    Publication date: November 8, 2012
    Applicant: BAYER TECHNOLOGY SERVICES GMBH
    Inventors: Martin Weiss, Dirk Storch, Wolfgang Wirth, Britta Olenik, Hans-Christoph Weiss, Ulrich Schwiedop
  • Publication number: 20120270904
    Abstract: The invention relates to a new co-crystal of 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one with oxalic acid, and also to processes for preparation thereof and use.
    Type: Application
    Filed: October 26, 2010
    Publication date: October 25, 2012
    Applicant: BAYER TECHNOLOGY SERVICES GMBH
    Inventors: Martin Weiss, Dirk Storch, Wolfgang Wirth, Britta Olenik, Ulrich Schwiedop, Hans-Christoph Weiss
  • Publication number: 20120252766
    Abstract: The invention relates to a new co-crystal of 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one (I) with salicylic acid, and also to processes for preparation thereof and use thereof.
    Type: Application
    Filed: October 26, 2010
    Publication date: October 4, 2012
    Applicant: BAYER ITECHNOLOGY SERVICES GMBH
    Inventors: Martin Weiss, Dirk Storch, Wolfgang Wirth, Britta Olenik, Hans-Christoph Weiss, Ulrich Schwiedop
  • Patent number: 8273904
    Abstract: Process for preparing 2,2-difluoroethylamine derivatives, wherein compounds of the general formula (IV) are reduced to the corresponding 2,2-difluoroethylamine derivatives of the general formula (III), where the A radical is as defined in the description:
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: September 25, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Norbert Lui, Jens-Dietmar Heinrich
  • Publication number: 20120232033
    Abstract: The invention relates to the use of compounds of formula I wherein the substituents are described in the description and claims for the treatment of psychoses, dysfunction in memory and learning, schizophrenia, dementia, attention deficit disorders or Alzheimer's disease. The invention also relates to some compounds of formula I and pharmaceutical compositions containing them.
    Type: Application
    Filed: May 25, 2012
    Publication date: September 13, 2012
    Inventors: Sabine Kolczewski, Hans-Peter Marty, Robert Narquizian, Emmanuel Pinnard, Henri Stalder
  • Publication number: 20120208807
    Abstract: This invention is directed to analogs of 5-(tetradecyloxy)-2-furancarboxylic acid (TOFA) and their use in the treatment of dermatological disorders or conditions characterized by sebaceous gland hyperactivity, such as acne and oily skin, and other dermatological disorders and conditions. This invention is also directed to pharmaceutical compositions comprising analogs of TOFA and a pharmaceutically acceptable excipient for dermatological or oral administration.
    Type: Application
    Filed: July 1, 2010
    Publication date: August 16, 2012
    Applicant: VALOCOR THERAPEUTICS, INC.
    Inventors: Timothy Scott Daynard, Geoffrey C. Winters, David W.C. Hunt
  • Publication number: 20120202817
    Abstract: A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R1 and R2 are hydrogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.
    Type: Application
    Filed: April 18, 2012
    Publication date: August 9, 2012
    Applicant: SANTEN PHARMACEUTICAL CO., LTD.
    Inventors: Takahiro Honda, Hisashi Tajima, Yoshimasa Sasabuchi, Kenji Kawashima, Kazuyoshi Okamoto, Minoru Yamamoto, Masakazu Ban
  • Publication number: 20120157498
    Abstract: The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.
    Type: Application
    Filed: December 22, 2011
    Publication date: June 21, 2012
    Applicant: Bayer CropScience AG
    Inventors: Peter JESCHKE, Robert Velten, Thomas Schenke, Otto Schallner, Michael Edmund Beck, Rolf Pontzen, Olga Malsam, Udo Reckmann, Ralf Nauen, Ulrich Görgens, Leonard Pitta, Thomas Müller, Christian Arnold, Erich Sanwald
  • Publication number: 20120101080
    Abstract: The invention relates to a pharmaceutical composition comprising a compound of formula (1) wherein R1 is optionally substituted phenyl, optionally substituted pyridyl or optionally substituted indolyl; R2 is (CH2)n wherein n is 0, 1, 2, 3 or 4; R3 is (CH2)mR3A wherein m is 0, 1, 2, 3 or 4, and R3A is methyl, isopropyl, tert-butyl, OCH3, OH, optionally substituted phenoxy, C?CH, C?N, optionally substituted phenyl, furanyl or thienyl; A is a ring containing X1 with the meaning O, S, NH, N(CH3) or CH2; and X2 is O, S or NH; and a compound of formula (2) wherein R4 is optionally substituted phenyl, optionally substituted pyridyl, optionally substituted indolyl, —NR7R8; or —NH—N?CH—R9; and substituents R5 to R9 have the meanings indicated in the description, in particular ethionamide. The pharmaceutical composition is useful, e.g., in the treatment of multidrug-resistant tuberculosis.
    Type: Application
    Filed: June 25, 2010
    Publication date: April 26, 2012
    Applicant: BioVersys AG
    Inventors: Ronald Schoenmakers, Wilfried Weber, Marc Gitzinger, Martin Fussenegger, Marcel Tigges, Peter Schneider
  • Publication number: 20120016132
    Abstract: The present invention relates to a process for the preparation of enaminocarbonyl compounds of the formula (I) where compounds of the formula (II) are reacted in the presence of a Brønsted acid to give compounds of the formula (I), and A, R1 and Z are as defined in the description, and also corresponding starting compounds which are used in the process according to the invention.
    Type: Application
    Filed: March 12, 2010
    Publication date: January 19, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Norbert Lui, Jens-Dietmar Heinrich
  • Publication number: 20120004416
    Abstract: The present invention relates to a process for preparing enaminocarbonyl compounds by reacting compounds of the formula (II) with compounds of the formula (III) in which the A, R1, R2 and Z radicals are each as defined in the description, in the presence of a Brønsted acid.
    Type: Application
    Filed: March 12, 2010
    Publication date: January 5, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Norbert Lui, Jens-Dietmar Heinrich
  • Publication number: 20110274803
    Abstract: The present invention relates to enaminocarbonyl compounds with the formula I, in which X denotes O or CH2, Y denotes N and each of R1 and R2 denotes hydrogen, or Y denotes a CH and either R1 or R2 denotes a C1-4 alkyl, and the remaining R1 or R2 denotes hydrogen, selected (for Y denoting CH and R1 or R2 denoting a C1-4 alkyl) from a group encompassing a mixture of R and S enantiomers enriched in either enantiomer R or enantiomer S, enantiomer R and enantiomer S. The present invention also relates to the use of compounds with the formula I, in which X denotes O or CH2, Y denotes a CH and either R1 or R2 is selected from a group encompassing hydrogen and a C1-4 alkyl, and the remaining R1 or R2 denotes hydrogen, for the modification of the taste of a product and/or preparation for oral administration.
    Type: Application
    Filed: February 2, 2010
    Publication date: November 10, 2011
    Inventors: Piotr Krajewski, Agnieszka Wozniak
  • Publication number: 20110183976
    Abstract: 5- and 6-membered heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Also described is the treatment of neurological, neurodegenerative and psychiatric disorders including but not limited to those comprising cognitive deficits or schizophrenic symptoms.
    Type: Application
    Filed: June 25, 2009
    Publication date: July 28, 2011
    Inventors: Amy Ripka, Gideon Shapiro, Richard Chesworth
  • Publication number: 20110152534
    Abstract: Process for the preparation of 4-aminobut-2-enolide compounds of the formula (I): comprising reaction of a 4-alkoxyfuran-2(5H)-one compound or 4-arylalkoxyfuran-2(5H)-one compound of the formula (II) with an amine of the formula (III) in which R1, R2 and A have the definitions given in the description, in the presence of a Brønstedt acid.
    Type: Application
    Filed: December 21, 2010
    Publication date: June 23, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Norber LUI, Jens-Dietmer Heinrich
  • Publication number: 20110105533
    Abstract: The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.
    Type: Application
    Filed: June 25, 2010
    Publication date: May 5, 2011
    Inventors: Anton F. J. Fliri, Randall James Gallaschun, Christopher John O'Donnell, Jacob Bradley Schwarz, Barbara E. Segelstein
  • Publication number: 20110054182
    Abstract: Process for the preparation of 4-aminobut-2-enolide compounds of the formula (I): comprising reaction of a 4-(methylamino)furan-2(5H)-one compound of the formula (II) with an amine of the formula (III) in which R1 and A have the definitions mentioned in the description, optionally in the presence of a Brønstedt acid.
    Type: Application
    Filed: August 17, 2010
    Publication date: March 3, 2011
    Applicant: Bayer CropScience AG
    Inventors: Norbert LUI, Jens-Dietmar Heinrich
  • Publication number: 20110039894
    Abstract: The present application relates to novel substituted enaminothiocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.
    Type: Application
    Filed: March 25, 2009
    Publication date: February 17, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Robert Velten, Peter Jeschke, Eva-Maria Franken
  • Publication number: 20110009454
    Abstract: Disclosed is a composition for agricultural use, which is used for controlling or preventing plant diseases caused by plant pathogens. The composition for agricultural use contains a compound represented by formula (1), a salt thereof or a hydrate of the compound or the salt. (1) [In the formula, Z represents an oxygen atom, a sulfur atom or NRZ; and E represents a furyl group, a thienyl group, a pyrrolyl group, a tetrazolyl group, a thiazolyl group, a pyrazolyl group, a phenyl group or the like.
    Type: Application
    Filed: February 27, 2009
    Publication date: January 13, 2011
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yuichi Matsuzaki, Takashi Komori, Tohru Inoue
  • Publication number: 20100292261
    Abstract: In the quorum sensing antagonist blocking the communication in bacteria, the method for preventing biofilm formation using this quorum sensing antagonist and the method for reducing the bacterial contamination, the quorum sensing antagonist contains the homoserine lactone moiety and sulfanylethanoyl group, and has a similar chemical structure to that of the autoinducer which is produced by bacteria as a signal, whereby the quorum sensing antagonist can inhibit the formation of biofilm and reduce the bacterial contamination as well.
    Type: Application
    Filed: May 3, 2007
    Publication date: November 18, 2010
    Applicant: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION
    Inventors: Je-Yong Yoon, Cheol-Jin Kim, Jae-Eun Kim, Hyung-Yeon Park
  • Publication number: 20100261724
    Abstract: The present invention is directed to heterocycle phenyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
    Type: Application
    Filed: October 23, 2008
    Publication date: October 14, 2010
    Inventors: James C. Barrow, Paul J. Coleman, Thomas S. Reger, Kelly-Ann S. Schlegel, Youheng Shu, Zhi-Qiang Yang
  • Publication number: 20100240705
    Abstract: The present application relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.
    Type: Application
    Filed: March 19, 2007
    Publication date: September 23, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Peter Jeschke, Robert Velten, Thomas Schenke, Otto Schallner, Michael Edmund Beck, Olga Malsam, Ralf Nauen, Thomas Müller, Christian Arnold, Erich Sanwald, Ulrich Görgens
  • Publication number: 20100204480
    Abstract: The present invention relates to a process for preparing 4-aminobut-2-enolides and also corresponding intermediates and starting compounds which are passed through or used in the process according to the invention.
    Type: Application
    Filed: September 5, 2008
    Publication date: August 12, 2010
    Applicant: BAYER CROPSCIENCE
    Inventors: Norbert Lui, Jens-Dietmar Heinrich
  • Publication number: 20100190990
    Abstract: Process for preparing 2,2-difluoroethylamine derivatives, wherein compounds of the general formula (IV) are reduced to the corresponding 2,2-difluoroethylamine derivatives of the general formula (III), where the A radical is as defined in the description:
    Type: Application
    Filed: September 5, 2008
    Publication date: July 29, 2010
    Applicant: Bayer Cropscience AG
    Inventors: Norbert Lui, Jens-Dietmar Heinrich