Polycyclo-carbocyclic Ring System Having At Least Three Cyclos Patents (Class 546/285)
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Publication number: 20130221332Abstract: Novel compounds containing a triphenylene moiety linked to an ?? connected binaphthyl ring system are provided. These compounds have surprisingly good solubility in organic solvents and are useful as host compounds in red phosphorescent OLEDs.Type: ApplicationFiled: December 18, 2012Publication date: August 29, 2013Applicant: Universal Display CorporationInventor: Universal Display Corporation
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Publication number: 20130210785Abstract: This disclosure relates to progesterone derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation resulting from traumatic brain injury or stroke.Type: ApplicationFiled: February 14, 2013Publication date: August 15, 2013Applicant: EMORY UNIVERSITYInventor: Emory University
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Publication number: 20130193382Abstract: The present invention relates to compounds of the formula (I) and to the use thereof in electronic devices. The invention furthermore relates to electronic devices, preferably organic electroluminescent devices (OLEDs), comprising one or more com-pounds of the formula (I). The invention again furthermore relates to the preparation of compounds of the formula (I) and to formulations comprising one or more compounds of the formula (I).Type: ApplicationFiled: September 6, 2011Publication date: August 1, 2013Applicant: MERCK PATENT GmbHInventors: Arne Buesing, Thomas Eberle, Irina Martynova, Teresa Mujica-Fernaud
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Patent number: 8492365Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: GrantFiled: June 9, 2009Date of Patent: July 23, 2013Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
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Patent number: 8455652Abstract: Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.Type: GrantFiled: March 2, 2009Date of Patent: June 4, 2013Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human ServicesInventors: Bruce D. Hammock, In-Hae Kim, Christophe Morisseau, Takaho Watanabe, John W. Newman
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Patent number: 8455653Abstract: Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors, useful in the treatment of psoriasis.Type: GrantFiled: October 26, 2012Date of Patent: June 4, 2013Assignee: Takeda GmbHInventor: Ulrich Kautz
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Publication number: 20130137699Abstract: The invention provides compounds of formula I or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for inducing apoptosis or treating cancer using compounds of formula I.Type: ApplicationFiled: December 23, 2010Publication date: May 30, 2013Inventors: Joseph A. Fontana, Marcia Dawson, Zebin Xia
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Patent number: 8440684Abstract: The present invention relates to novel polycyclic pyrrolidine-2,5-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.Type: GrantFiled: July 3, 2012Date of Patent: May 14, 2013Assignee: Allergan, Inc.Inventors: Richard L. Beard, Vidyasagar Vuligonda, Thong Vu, John E. Donello, Veena Viswanath, Michael E. Garst
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Publication number: 20130056722Abstract: A novel organic compound is suitable for emitting green light. An organic light-emitting device includes the novel organic compound.Type: ApplicationFiled: May 11, 2011Publication date: March 7, 2013Applicant: CANON KABUSHIKI KAISHAInventors: Yosuke Nishide, Jun Kamatani, Akihito Saitoh
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Patent number: 8383820Abstract: Novel substituted benzamide based inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration of said compounds are described. The present compounds modulate the activity of 11?-hydroxysteroid dehydrogenase type 1 (11?HSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, such as the metabolic syndrome.Type: GrantFiled: February 19, 2008Date of Patent: February 26, 2013Assignee: High Point Pharmaceuticals, LLCInventor: Soren Ebdrup
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Patent number: 8378112Abstract: Disclosed is a gap junction inhibitor which is more practically useful compared with carbenoxolone. Also disclosed is a novel glycyrrhetinic acid derivative. The glycyrrhetinic acid derivative is represented by general formula (1) or (2).Type: GrantFiled: July 15, 2009Date of Patent: February 19, 2013Assignees: INI Corporation, University Corporation Nagoya UniversityInventors: Hideyuki Takeuchi, Akio Suzumura
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Publication number: 20130038515Abstract: There is provided a novel organic compound suitably used for a blue light-emitting device and an organic light-emitting device including the novel organic compound. The organic compound is an acephenanthryleno[4,5-k]benzo[e]acephenanthrylene derivative.Type: ApplicationFiled: April 19, 2011Publication date: February 14, 2013Applicant: CANON KABUSHIKI KAISHAInventors: Tomonari Horikiri, Hiroyuki Tomono, Jun Kamatani
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Publication number: 20130002526Abstract: A novel organic compound suitable for emitting green light and an organic light-emitting device including the organic compound are provided. The organic compound is represented by general formula (1). In general formula (1), R1 to R18 are each independently selected from a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted amino group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group.Type: ApplicationFiled: March 22, 2011Publication date: January 3, 2013Applicant: CANON KABUSHIKI KAISHAInventors: Jun Kamatani, Kengo Kishino, Naoki Yamada, Akihito Saitoh
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Publication number: 20120322801Abstract: The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.Type: ApplicationFiled: March 4, 2011Publication date: December 20, 2012Applicant: Amakem NVInventors: Dirk Leysen, Olivier Defert, Nadzeya Kaval, Petra Blom, Sandro Boland
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Patent number: 8334305Abstract: Novel substituted amide inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration of said compounds are described. The present compounds modulate the activity of 11?-hydroxysteroid dehydrogenase type 1 (11?HSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, such as the metabolic syndrome.Type: GrantFiled: February 19, 2008Date of Patent: December 18, 2012Assignee: High Point Pharmaceuticals, LLCInventor: Soren Ebdrup
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Patent number: 8324391Abstract: Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors.Type: GrantFiled: May 19, 2011Date of Patent: December 4, 2012Assignee: Nycomed GmbHInventor: Ulrich Kautz
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Patent number: 8318944Abstract: Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors.Type: GrantFiled: May 19, 2011Date of Patent: November 27, 2012Assignee: Nycomed GmbHInventor: Ulrich Kautz
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Publication number: 20120286251Abstract: Embodiments of the present invention are directed to a compound represented by Formula 1, and an organic light-emitting device including an organic film that includes the compound of Formula 1:Type: ApplicationFiled: April 19, 2012Publication date: November 15, 2012Inventors: Soo-Jin Park, Tsuyoshi Naijo, Keon-Ha Choi, Ji-Hye Shim, Jong-Tae Je, Jeong-Soo Kim, Hyun-Jung Kwon, Yoo-Na Shin
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Publication number: 20120283201Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: ApplicationFiled: July 12, 2012Publication date: November 8, 2012Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhalie, Atul K. Verma, Laura Honeyman, Tadeusz Warchol, David Messersmith
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Patent number: 8304415Abstract: A series of novel 1,2-disubstituted amido-anthraquinone derivatives, and the preparation method and application of said derivatives. Said application includes said derivatives with therapeutically effective amount being prepared into pharmaceutical compositions for inhibition of cancer cell growth, further treating cancer.Type: GrantFiled: February 25, 2010Date of Patent: November 6, 2012Assignee: National Defense Medical CenterInventors: Hsu-Shan Huang, Chia-Chung Lee
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Patent number: 8288018Abstract: An amino compound for an organic light-emitting device of general formula [1]: wherein X1 is bonded to the pair of fluorenyl groups at meta-positions to each other and is substituted or unsubstituted aromatic ring, fused polycyclic ring, or heterocyclic ring; Y1 and Y2 are each substituted or unsubstituted alkyl, aryl, or heterocyclic and are the same or different; Z1 to Z4 are each hydrogen, halogen, or substituted or unsubstituted alkyl, aralkyl, alkenyl, alkynyl, alkoxy, aryl, or heterocyclic and are the same or different; R1 to R4 are each hydrogen, halogen, or substituted or unsubstituted alkyl, aryl, or heterocyclic and are the same or different; a and d are each 1 to 4; and b and c are each 1 to 3.Type: GrantFiled: April 27, 2011Date of Patent: October 16, 2012Assignee: Canon Kabushiki KaishaInventors: Shigemoto Abe, Akihiro Senoo, Naoki Yamada, Chika Negishi
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Publication number: 20120238549Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.Type: ApplicationFiled: March 15, 2012Publication date: September 20, 2012Applicant: ABBOTT LABORATORIESInventors: Kevin P. Cusack, Thomas D. Gordon, David C. Ihle, Martin E. Hayes, Eric C. Breinlinger, Anna M. Ericsson, Bin Li, Lei Wang, Gloria Y. Martinez, Andrew Burchat, Adrian D. Hobson, Kelly D. Mullen, Michael Friedman, Michael J. Morytko
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Publication number: 20120217449Abstract: The present invention relates to compounds of the general formula (I), to the use thereof in electronic devices, preferably as host material for fluorescent dopants or as fluorescent dopant, to a process for the preparation of the compounds of the formula (I), and to electronic devices comprising compounds of the formula (I).Type: ApplicationFiled: October 19, 2010Publication date: August 30, 2012Applicant: Merck Patent GmbHInventors: Hubert Spreitzer, Jochen Schwaiger, Heinrich Becker, Frank Voges, Holger Heil
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Patent number: 8232300Abstract: A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH2)3—or —(CH2)4—, X represents —N(R2)—CO—(R2 represents hydrogen atom or a C1-6 alkyl group), —CO—N(R3)—(R3 represents hydrogen atom or a C1-6 alkyl group), —C(R4)?C(R5)—(R4 and R5 represent hydrogen atom or a C1-6 alkyl group), or —N(R6)—SO2—(R6 represents hydrogen atom or a C1-6 alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has a retinoid action and is useful as an active ingredient of a medicament.Type: GrantFiled: August 14, 2008Date of Patent: July 31, 2012Assignee: Research Foundation Itsuu LaboratoryInventors: Yohei Amano, Masayuki Noguchi, Koichi Shudo
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Patent number: 8222519Abstract: A merocyanine dye is provided. The merocyanine dye is represented by formula (1). In the formula (1), A1 represents a divalent atomic group, n represents an integer of 1 to 3, A2 and A3 each independently represent an aromatic hydrocarbon ring or a heterocyclic ring having 3 to 18 carbon atoms, and R11 and R12 each independently represent a hydrogen atom, an alkyl group having 1 to 18 carbon atoms, an aryl group having 6 to 18 carbon atoms, or a heterocyclic group having 3 to 18 carbon atoms.Type: GrantFiled: January 16, 2009Date of Patent: July 17, 2012Assignee: FUJIFILM CorporationInventors: Kimiatsu Nomura, Rui Shen, Hideyuki Suzuki
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Publication number: 20120177634Abstract: This disclosure concerns novel demethylpenclomedine analogs. Also disclosed are pharmaceutical compositions and methods for using such compositions to treat hyperproliferative disorders.Type: ApplicationFiled: February 22, 2012Publication date: July 12, 2012Inventor: Lee Roy Morgan
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Publication number: 20120156491Abstract: A SERS tag comprising a core comprising at least two aggregated particles of a SERS enhancing material wherein the contact point between the particles defines a crevice; and a reporter molecule having a length sufficiently short to fit into the crevice and a conjugated path length which is as large as possible, provided the overall reporter molecule length is maintained sufficiently short to fit into the crevice.Type: ApplicationFiled: June 17, 2011Publication date: June 21, 2012Applicant: CABOT SECURITY MATERIALS INC.Inventors: Felicia Tam, Marcelo E. Piotti, Richard G. Freeman
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Publication number: 20120142707Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 betulinic acid and other structurally related natural products derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.Type: ApplicationFiled: June 2, 2011Publication date: June 7, 2012Inventors: Alicia Regueiro-Ren, Jacob Swidorski, Zheng Liu, Nicholas A. Meanwell, Sing-Yuen Sit, Jie Chen
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Publication number: 20120135968Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.Type: ApplicationFiled: May 7, 2010Publication date: May 31, 2012Inventors: Chi-Li Chen, Roger B. Clark, Yonghong Deng, Minsheng He, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Magnus Rönn
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Publication number: 20120115818Abstract: Efficient method for preparing the enone intermediate (VII) used in the synthesis of tetracyclines derivatives. In particular, the invention provides a synthesis which allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.Type: ApplicationFiled: April 30, 2010Publication date: May 10, 2012Applicant: President and Felows of Harvard CollegeInventors: Andrew G. Myers, David A. Kummer, Derun Li, Evan Hecker, Amelie Dion, Peter M. Wright
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Publication number: 20120115819Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.Type: ApplicationFiled: May 13, 2010Publication date: May 10, 2012Inventors: Roger B. Clark, Diana Katharine Hunt, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Magnus P. Rönn
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Publication number: 20120112177Abstract: An amine derivative represented by the following general formula (1) and exhibiting a temperature difference of 30° C. or more as defined by the difference of [decomposition temperature (° C.) minus sublimation temperature (° C.)]: wherein R1 and R2 independently represent a substituted or unsubstituted C6-40 aryl or C5-40 heteroaryl group; and R3 and R4 independently represent a hydrogen atom, a straight-chain, branched or cyclic C1-18 alkyl or C1-18 alkoxy group, or a substituted or unsubstituted C6-40 aryl or C5-40 heteroaryl group, provided that R3 and R4 may form together a cyclic hydrocarbon group. The amine derivative is useful as an organic electroluminescent material.Type: ApplicationFiled: June 2, 2010Publication date: May 10, 2012Applicant: TOSOH CORPORATIONInventors: Shinichi Ishikawa, Naoki Matsumoto, Takanori Miyazaki, Yasushi Hara
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Publication number: 20120091450Abstract: The present invention provides organic compounds which are indenobenzo[k]fluoranthene derivatives represented by the following general formula (1): In general formula (1), R1 to R14 are each independently selected from a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an amino group, an aryl group, and a heterocyclic group.Type: ApplicationFiled: April 27, 2010Publication date: April 19, 2012Applicant: CANON KABUSHIKI KAISHAInventors: Jun Kamatani, Naoki Yamada, Akihito Saitoh
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Publication number: 20120091885Abstract: Disclosed are novel organic electroluminescent compounds and organic electroluminescent devices comprising the same. With good luminous efficiency and excellent life property, the disclosed organic electroluminescent compounds can be used to manufacture OLED devices having very good operation life.Type: ApplicationFiled: March 29, 2010Publication date: April 19, 2012Applicant: Rohm and Haas Electronic Materials Korea Let.Inventors: Young Gil Kim, Young Jun Chop, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
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Patent number: 8148409Abstract: The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.Type: GrantFiled: July 20, 2009Date of Patent: April 3, 2012Assignee: Pfizer Inc.Inventor: Paul V. Rucker
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Publication number: 20120065066Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: May 16, 2009Publication date: March 15, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: Christopher John Mathews, Louisa Robinson, Stephane Andre Marie Jeanmart
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Publication number: 20120065247Abstract: Provided herein are compounds and methods for use in preventing or treating a viral infection mediated by a virus comprising an IRES-containing RNA molecule or cancer related to an increase or decrease in IRES-mediated translation of an RNA molecule. Also provided are methods of inhibiting or promoting IRES-mediated translation. Also provided are methods of screening for an agent that inhibits IRES-mediated translation.Type: ApplicationFiled: March 26, 2010Publication date: March 15, 2012Applicants: DiscoveryBiomed, Inc., The UAB Research FoundationInventors: Sunnie R. Thompson, Erik Mills Schwiebert, John H. Streiff
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Patent number: 8124596Abstract: This disclosure concerns novel demethylpenclomedine analogs. Also disclosed are pharmaceutical compositions and methods for using such compositions to treat hyperproliferative disorders. In one embodiment the analogs are represented by the formula (1).Type: GrantFiled: December 12, 2006Date of Patent: February 28, 2012Assignee: Dekk-Tec, Inc.Inventor: Lee Roy Morgan
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Publication number: 20120037892Abstract: The present invention relates to a novel cycloalkene derivative, and an organic electronic device using the same. The cycloalkene derivative according to the exemplary embodiment of the present invention may act as a hole injection, a hole transport, an electron injection, an electron transport, or a light emitting material in an organic light emitting diode and an organic electronic device, and in particular, may be used alone as a light emitting host or a dopant.Type: ApplicationFiled: January 20, 2010Publication date: February 16, 2012Applicant: LG CHEM, LTD.Inventors: Hye-Young Jang, Jae-Chol Lee, Jae-Soon Bae, Jeung-Gon Kim, Seong-So Kim, Chang-Hwan Kim
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Publication number: 20120028800Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: January 25, 2010Publication date: February 2, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
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Publication number: 20120025183Abstract: Provided is an acenaphtho[1,2-k]benzo[e]acephenanthrene derivative represented by general formula (1): wherein R1 to R16 are each independently selected from a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group; and at least one of R1 to R8 and R10 to R15 is selected from a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group.Type: ApplicationFiled: April 22, 2010Publication date: February 2, 2012Applicant: CANON KABUSHIKI KAISHAInventors: Jun Kamatani, Takayuki Horiuchi, Naoki Yamada, Akihito Saitoh
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Publication number: 20120001161Abstract: Disclosed is an organic electroluminescent element which has achieved both high luminous efficiency and low driving voltage by containing a light-emitting element material, which comprises a specific pyrene compound, in one of the layers that constitute the light-emitting element, preferably in a light-emitting layer or in an electron-transporting layer.Type: ApplicationFiled: March 25, 2010Publication date: January 5, 2012Applicant: TORAY INDUSTRIES, INC.Inventors: Yohei Nakano, Kazunori Sugimoto, Kazumasa Nagao, Daisaku Tanaka, Tsuyoshi Tominaga
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Patent number: 8084610Abstract: Improved compositions have been developed which are selectively sequestered in acidic areas of tumors. When the compositions contain a radioisotope effective to report the presence of the composition, the compositions are useful for detecting tumors. When the compositions contain radioisotopes effective to kill cells, the compositions are useful for treating tumors. Methods for detecting and treating tumors with such compositions are also disclosed.Type: GrantFiled: June 7, 2006Date of Patent: December 27, 2011Inventor: James Edward Summerton
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Publication number: 20110295017Abstract: A highly stable organic EL material having the properties of both benzofluoranthene and anthracene structures is provided. The organic EL device has at least one organic compound layer containing a compound presented by the general formula (I) below: (in which L is a linking group linking any one of the positions 1 to 12 and any one of the positions 13 to 22; the unlinked positions 1 to 22 are substituted by any of a hydrogen atom, substituted or unsubstituted aryl group, substituted or unsubstituted heterocyclic group, substituted or unsubstituted alkyl group, and aromatic amino group; and L presents any of a single bond, substituted or unsubstituted arylene group, substituted or unsubstituted heterocyclic group, and substituted or unsubstituted alkylene group).Type: ApplicationFiled: May 27, 2011Publication date: December 1, 2011Applicant: TDK CorporationInventors: Akira EBISAWA, Hajime Amano, Sumiko Kitagawa, Tetsushi Inoue
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Publication number: 20110251394Abstract: An organic compound is represented by general formula (1): where R1 to R18 are each independently selected from a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group.Type: ApplicationFiled: December 16, 2009Publication date: October 13, 2011Applicant: CANON KABUSHIKI KAISHAInventors: Jun Kamatani, Naoki Yamada, Akihito Saitoh
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Patent number: 8034827Abstract: The present invention relates to new phenanthridine derivatives of formula (I), wherein the variables are as defined in the specification, to processes for producing the same, to pharmacological compositions containing the same and to their use in therapy or prevention of painful and inflammatory processes.Type: GrantFiled: December 19, 2006Date of Patent: October 11, 2011Assignee: Richter Gegeon Nyrt.Inventors: Gyula Beke, Eva Bozo, Gabor Czira, Janos Eles, Sandor Farkas, Katalin Hornok, Eva Schmidt, Eva Szentirmay, Istvan Vago, Monika Vastag
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Publication number: 20110245501Abstract: The present invention relates to substituted tetracycline compounds and related methods for increasing the antifungal activity of an antifungal agent. The methods include administering to a subject an effective amount of a substituted tetracycline compound in combination with an antifungal agent such that the subject is treated for the fungal associated disorder.Type: ApplicationFiled: June 14, 2011Publication date: October 6, 2011Applicant: Paratek Pharmaceuticals, Inc.Inventors: Michael Draper, Mark L. Nelson
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Publication number: 20110224244Abstract: Embodiments of the present invention provide adamantyl benzamide derivtives and pharmaceutical compositions comprising adamantyl benzamide derivatives. Methods of use of such compounds and compositions to modulate the activity of 11?-hydroxysteroid dehydrogenase type 1 (11?HSD1) in a subject are also provided.Type: ApplicationFiled: November 17, 2009Publication date: September 15, 2011Applicant: HIGH POINT PHARMACEUTICALS, LLCInventors: Dharma Rao Polisetti, Suparna Gupta, Soren Ebdrup
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Patent number: 8003798Abstract: Compounds of the formula I in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors.Type: GrantFiled: March 2, 2005Date of Patent: August 23, 2011Assignee: NYCOMED GmbHInventor: Ulrich Kautz
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Patent number: 7994333Abstract: The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders are provided which include administration of compound of Formula I: wherein the constituent variables are defined herein.Type: GrantFiled: November 7, 2008Date of Patent: August 9, 2011Assignee: Wyeth LLCInventors: Neelu Kaila, Silvano L. Debarnardo, Kristin M. Janz, Raymond T. Camphausen, Patricia Ward Bedard, Adrian Huang