Arsenic Containing Patents (Class 546/3)
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Publication number: 20150129840Abstract: A novel emitter compound having the formula Os(L1)(L2)(L3) and a novel method of making such compounds are disclosed. In the formula Os(L1)(L2)(L3), each of L1, L2, and L3 is independently a bidentate ligand. The method includes (a) reacting a precursor of ligand L1 with an osmium precursor to form a first intermediate product that has the ligand L1 coordinated to the osmium, wherein the osmium precursor has the formula OsHx(PR3)y, wherein x is an integer from 2 to 6 and y is an integer from 2 to 5, and R is selected from the group consisting of aryl, alkyl and cycloalkyl; (b) reacting the first intermediate product with a reducing agent to form a Os(II) second intermediate product; (c) reacting the second intermediate product with a coordinating solvent to form a third intermediate product; and (d) reacting a mixture of ligands L2 and L3 with said third intermediate product.Type: ApplicationFiled: November 8, 2013Publication date: May 14, 2015Applicant: Universal Display CorporationInventors: Jui-Yi Tsai, Chuanjun Xia, Miguel A. Esteruelas, Enrique Oñate Rodriguez, Tamara Bolano, Adrian U. Palacios
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Publication number: 20140121165Abstract: The present invention relates to process for identifying a compound which induces the mitochondrial permeability transition (MPT) in proliferating cells, wherein said process comprises contacting a cell or cell extract with a compound, determining whether the compound binds to adenine nucleotide translocator (ANT), and determining whether the compound selectively induces the MPT in proliferating cells.Type: ApplicationFiled: October 25, 2013Publication date: May 1, 2014Applicant: NewSouth Innovations Pty LimitedInventor: Philip John Hogg
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Patent number: 8133709Abstract: The invention is based on the discovery that certain biarsenical molecules react with specified target sequences, thereby providing a facile means for labeling polypeptides containing the target sequence. The invention is useful in creating stable mammalian cell lines expressing a certain tetracysteine tagged polypeptides, thereby overcoming toxicity associated with native tetracysteine. In addition, the invention allows for orthogonal labeling of polypeptides, thereby allowing for the observation of protein-protein interactions and conformational changes in proteins, for example.Type: GrantFiled: April 3, 2008Date of Patent: March 13, 2012Assignee: Life Technologies CorporationInventor: George Hanson
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Publication number: 20110269697Abstract: A method for treating a lymphoma selected from non-Hodgkin's and Hodgkin's lymphoma comprising administering an organoarsenic compound having a structure of the formula (I) wherein X is S or Se and R1 and R2 are independently C1-30alkyl(R3, R3?, R4, R5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.Type: ApplicationFiled: August 14, 2009Publication date: November 3, 2011Inventors: Brian Eric Schwartz, Jonathan Lewis, Philip B. Komarnitsky
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Publication number: 20110229929Abstract: The invention provides methods and compositions for labeling dithiol-containing analytes.Type: ApplicationFiled: March 21, 2011Publication date: September 22, 2011Inventors: Laura Ellen Downs Beaulieu, Mary J. Tanga
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Publication number: 20110015396Abstract: Disclosed herein is a class of tunable phenylacetylene compounds as well as compositions and methods for their use as host compounds for ligand binding. In certain examples the hosts report binding events by exhibiting altered spectroscopic properties, such as different fluorescent emission spectra.Type: ApplicationFiled: September 28, 2010Publication date: January 20, 2011Applicant: The State of Oregon on behalf of the University of OregonInventors: Michael M. HALEY, Darren W. JOHNSON, Orion B. BERRYMAN, Charles A. JOHNSON, Calden N. STIMPSON
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Patent number: 7799926Abstract: The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.Type: GrantFiled: March 9, 2006Date of Patent: September 21, 2010Assignee: CepheidInventor: Alexander A Gall
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Patent number: 7728137Abstract: The present invention relates to new types of metal complexes. Such compounds can be used as active components (=functional materials) in a series of different types of applications which can be classed within the electronics industry in the widest sense. The inventive compounds are described by the structure 1 and the formulae (1) to (60).Type: GrantFiled: March 9, 2004Date of Patent: June 1, 2010Assignee: Merck Patent GmbHInventors: Philipp Stössel, Hubert Spreitzer
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Patent number: 7696349Abstract: The present invention relates to a process for asymmetric synthesis in the presence of a chiral catalyst comprising at least one complex of a metal of transition group VIII with ligands capable of dimerization via noncovalent bonds, such catalysts and their use.Type: GrantFiled: September 24, 2008Date of Patent: April 13, 2010Assignee: BASF SEInventors: Christoph Jäkel, Martin Volland, Thomas Mackewitz, Rocco Paciello, Bernhard Breit, Wolfgang Seiche, Martine Weis, Christoph Waloch
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Publication number: 20090233894Abstract: The present invention provides organic arsenicals which may be used to treat numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.Type: ApplicationFiled: January 16, 2007Publication date: September 17, 2009Applicant: The Texas A&M University SystemInventor: Ralph A. Zingaro
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Publication number: 20080254546Abstract: A molecular probe comprises two arsenic atoms and at least one cyanine based moiety. A method of producing a molecular probe includes providing a molecule having a first formula, treating the molecule with HgOAc, and subsequently transmetallizing with AsCl3. The As is liganded to ethanedithiol to produce a probe having a second formula. A method of labeling a peptide includes providing a peptide comprising a tag sequence and contacting the peptide with a biarsenical molecular probe. A complex is formed comprising the tag sequence and the molecular probe. A method of studying a peptide includes providing a mixture containing a peptide comprising a peptide tag sequence, adding a biarsenical probe to the mixture, and monitoring the fluorescence of the mixture.Type: ApplicationFiled: April 12, 2007Publication date: October 16, 2008Inventors: M. Uljana Mayer-Cumblidge, Haishi Cao
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Patent number: 6921824Abstract: New ruthenium dimeric complexes with high antimetastatic and antitumour activity and remarkable chemical stability are described.Type: GrantFiled: April 18, 2000Date of Patent: July 26, 2005Assignee: SIGEA S.r.l.Inventors: Giovanni Mestroni, Enzo Alessio, Gianni Sava, Elisabetta Iengo, Sonia Zorzet, Alberta Bergamo
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Patent number: 6686458Abstract: The present invention features biarsenical molecules. Target sequences that specifically react with the biarsenical molecules are also included. The present invention also features kits that include biarsenical molecules and target sequences. Tetraarsenical molecules are also featured in the invention.Type: GrantFiled: April 19, 2002Date of Patent: February 3, 2004Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, B. Albert Griffin
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Patent number: 6372909Abstract: Disclosed is a process for preparing a compound having the formula: wherein R, R1, R2, R3, and R4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy, by (A) reacting a compound having the formula wherein RA, RC, RD, and RE are independently selected from the group consisting of H, halo, alkyl, or alkoxy, and R5 is aryl or heteroaryl, with a dehydrating agent to produce an imine having the formula: (B) hydrolyzing the imine produced in step (A) to produce the compound having formula (I). Also disclosed are novel intermediates having the formula: wherein RA, RB, RC, RD, and RE are independently selected from the group consisting of H, halo, alkyl, or alkoxy, and R5 is aryl or heteroaryl.Type: GrantFiled: November 18, 1999Date of Patent: April 16, 2002Assignee: Schering CorporationInventors: Charles F. Bernard, Michael Casey, Frank Xing Chen, Denise C. Grogan, Marc Poirier, Robert P. Williams, Yee-Shing Wong, George G. Wu
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Patent number: 6179937Abstract: The stability of HAN, HAN derivatives or hydroxylamine, and compositions comprising these is considerably enhanced by employing a stabilizing effective amount of a stabilizer selected from (a) a pyridine or pyridone salt, or an acid thereof; (b) a diphosphonate or methylenephosphonate salt, or an acid thereof; or (c) a mixture of two or more stabilizers, wherein at least one is selected from (a) and at least one is selected from (b). Stabilized HAN, HAN derivatives, or hydroxylamine or compositions comprising HAN, an HAN derivative or hydroxylamine, along with a process for providing these stabilized compositions is described. A stabilizer mixture having enhanced, synergistic stabilizing properties is described as well.Type: GrantFiled: October 1, 1998Date of Patent: January 30, 2001Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Chares S. Leveritt, Steven W. Bunte, Eugene F. Rothgery, Carl G. Seefried, Nathan Klein
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Patent number: 6008378Abstract: The present invention features biarsenical molecules. Target sequences that specifically react with the biarsenical molecules are also included. The present invention also features kits that include biarsenical molecules and target sequences. Tetraarsenical molecules are also featured in the invention.Type: GrantFiled: October 21, 1997Date of Patent: December 28, 1999Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, B. Albert Griffin
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Patent number: 5908931Abstract: The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for completing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.Type: GrantFiled: December 14, 1990Date of Patent: June 1, 1999Assignee: Mallinckrodt Inc.Inventors: Raghavan Rajagopalan, William L. Neumann, Dennis L. Nosco
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Patent number: 5869721Abstract: A novel trivalent Group IVB metal complex for preparing syndiotactic vinyl aromatic polymers is disclosed which is coordinated by a bidentate ligand and is represented by the formula (I):(C.sub.5 R.sub.n H.sub.5-n)M(BD).sub.m Y.sub.p (I)wherein C.sub.5 R.sub.n H.sub.5-n is a substituted or unsubstituted cyclopentadienyl group, n is an integer between 0 and 5, and R is C.sub.1 to C.sub.12 alkyl, aryl, substituted alkyl, or substituted aryl; M is a trivalent Group IVB metal; (BD) is a bidentate ligand with -1 valence, having a coordinating group which is capable of forming a coordinating bond or a chelating bond with the metal M; Y is selected from the group consisting of alkyl, aryl, aralkyl, halogen and hydrogen; m is an integer of 1 or 2; and m+p=2.Type: GrantFiled: June 23, 1997Date of Patent: February 9, 1999Assignee: Industrial Technology Research InstituteInventors: Yi-Chun Chen, Jing C. Tsai, W. P. Chao
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Patent number: 5258169Abstract: Silicon diimide having a carbon content of at most 0.5% by weight and a chlorine content of at most 20 ppm is prepared by reacting ammonia with organyl amino silane at 50.degree.-300.degree. C. at elevated pressure and is useful as an intermediate for high grade silicon nitride.Type: GrantFiled: September 20, 1991Date of Patent: November 2, 1993Assignee: Bayer AktiengesellschaftInventors: Ulrich Wannagat, Adrian Schervan, Martin Jansen, Hans-Peter Baldus, Aloys Eiling
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Patent number: 5164502Abstract: Chloro and bromophenols and N-acylanilines are fluorinated in an ortho or para position with an N-fluoropyridinium salt to obtain fluorohalophenols and N-acylfluorohaloanilines, which can be further converted to fluorophenols and N-acylfluoroanilines by reduction. Thus, o-fluorophenol is obtained by fluorination of p-bromophenol with 2-chloro-6-(trichloromethyl)pyridinium fluoroborate and reduction of the product obtained with sodium formate and a palladium catalyst. N-Fluoropyridinium salts having trichloromethyl substituents are disclosed.Type: GrantFiled: November 8, 1991Date of Patent: November 17, 1992Assignee: DowElancoInventors: Alexander P. Fung, M. Moklesur Rahman, Thomas J. Dietsche
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Patent number: 5116982Abstract: Chloro and bromophenols and N-acylanilines are fluorinated in an ortho or para position with an N-fluoropyridinium salt to obtain fluorohalophenols and N-acylfluorohaloanilines, which can be further converted to fluorophenols and N-acylfluoroanilines by reduction. Thus, o-fluorophenol is obtained by fluorination of p-bromophenol with 2-chloro-6-(trichloromethyl)-pyridinium fluoroborate and reduction of the product obtained with sodium formate and a palladium catalyst. N-fluoropyridinium salts having trichloromethyl substituents are disclosed.Type: GrantFiled: August 6, 1990Date of Patent: May 26, 1992Assignee: DowElancoInventors: Alexander P. Fung, M. Moklesur Rahman, Thomas J. Dietsche
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Patent number: 4851396Abstract: Nicotinic acid derivatives They are of formula: ##STR1## with: Z=OR, with R=optionally substituted C.sub.1 -C.sub.18 -alkyl, C.sub.2 -C.sub.18 -alkenyl, C.sub.2 -C.sub.5 -alkynyl, phenyl or phenoxy;Y=H, hal, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy andn=1 to 3.Fungicidal products for agricultural use.Type: GrantFiled: May 18, 1987Date of Patent: July 25, 1989Assignee: Rhone-Poulenc AgrochimieInventors: Claude Lambert, Regis Pepin
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Patent number: 4695642Abstract: A new crystalline zirconium phosphate composition and method for its synthesis are provided. The composition has ion exchange properties and is readily convertible to catalytically active material by thermal treatment.Type: GrantFiled: September 2, 1986Date of Patent: September 22, 1987Assignee: Mobil Oil CorporationInventors: E. G. Derouane, R. M. Dessau, I. J. Heilweil, G. T. Kerr
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Patent number: 4550186Abstract: A compound of the formula[Cu(R.sub.3 NBH.sub.2 CO.sub.2).sub.2. R.sub.3 NBH.sub.2 CO.sub.2 H].sub.2wherein each R independently represents H, C.sub.1 -C.sub.10 alkyl, or phenyl and L represents a non-toxic Lewis base capable of forming a coordinate bond with the copper with the provisos that any two or three R attached to the same nitrogen may represent a C.sub.4 -C.sub.5 alkylene group containing up to 2 non-cumulative double bonds optionally having 1 or 2 carbons replaced by oxygen or nitrogen, that any 3 R attached to the same nitrogen when taken together with the nitrogen may represent a 6-membered aromatic ring containing 1, 2 or 3 nitrogen atoms, and that any R containing a carbon atom may be substituted with a hydroxyl, ether, ester, carboxyl, or amino functional group is disclosed along with methods of making these compounds and methods of using these compounds as antihyperlipidemic agents and antineoplastic agents.Type: GrantFiled: July 11, 1983Date of Patent: October 29, 1985Assignee: Duke UniversityInventors: Andrew T. McPhail, Bernard F. Spielvogel, Iris H. Hall
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Patent number: 4353912Abstract: N-substituted haloalkyl apomorphines of the formula ##STR1## wherein R.sub.1 is hydrogen or R.sub.2 O; R.sub.2 is hydrogen, acyl, lower alkyl or ##STR2## R.sub.3 and R.sub.4 are lower alkyl; and X is halogen; and their acid addition salts. Representative compounds have neuroleptic properties.Type: GrantFiled: May 8, 1980Date of Patent: October 12, 1982Assignee: Northeastern UniversityInventor: John L. Neumeyer
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Patent number: 4238394Abstract: A method is provided for making certain diaryliodonium salt photoinitiators, based on the initial formation of a diaryliodonium bisulfate. Methylene chloride is substituted for acetic acid during the reaction between potassium iodate and benzene in the presence of acetic anhydride and sulfuric acid. The diaryliodonium bisulfate is then reacted with a counterion source, such as a metal salt, to produce the desired diaryliodonium salt which can be used as a photoinitiator. The iodonium salt photoinitiators made by the method of the present invention can be used to make UV curable compositions.Type: GrantFiled: October 30, 1978Date of Patent: December 9, 1980Assignee: General Electric CompanyInventors: James V. Crivello, Julia H. W. Lam
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Patent number: 4231947Abstract: Tantalum and niobium catalysts or catalyst precursors of the formula: ##STR1## wherein R is cyclopentadienyl, which can be substituted with methyl up to five positions, or neopentylidene, R.sup.1 is neopentyl or benzyl, n is 0 or 1, R.sup.2 is neopentylidene, benzylidene, tetramethylene, or 2,3-dimethyltetramethylene, A is halo or a moiety of the formula YR.sup.3 R.sup.4 R.sup.5 wherein Y is a group 5 element including N, P, As, Sb and Bi and R.sup.3, R.sup.4, R.sup.5 can be the same or different and are C.sub.1 -C.sub.4 alkyl, aralkyl such as naphthyl, neophyl, tolyl or xylyl, aryl such as benzyl or phenyl or bipyridyl and Z is tantalum or niobium. The compounds selectively dimerize 1-olefins to 1-butenes; m=1 or 2.Type: GrantFiled: January 2, 1979Date of Patent: November 4, 1980Assignee: Massachusetts Institute of TechnologyInventor: Richard R. Schrock
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Patent number: 4136102Abstract: Halogen onium salts, and onium salts of Group VA and V1A elements having an MF.sub.6.sup.- anion, where M is selected from P, As and Sb, have been found to exhibit unusual activity under ultraviolet light. These onium salts can be employed as cationic photoinitiators when used with a variety of organic resins and cyclic organic compounds.Type: GrantFiled: April 21, 1973Date of Patent: January 23, 1979Assignee: General Electric CompanyInventor: James V. Crivello
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Patent number: 4124533Abstract: Process for the homogeneous catalytic hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in the presence of an optically active coordinated metal complex hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum.This process is a generalized process for any asymmetric hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in which one .alpha.-amino acid enantiomorph is the desired end-product. It is especially useful for the preparation of .alpha.-amino acids found in nature which possess optical activity and which have a hydrogen attached to the asymmetric center.This invention also relates to new optically active coordinated metal complex hydrogenation catalysts.Type: GrantFiled: March 17, 1975Date of Patent: November 7, 1978Assignee: Monsanto CompanyInventors: William S. Knowles, Milton J. Sabacky
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Patent number: RE33009Abstract: A new crystalline zirconium phosphate composition and method for its synthesis are provided. The composition has ion exchange properties and is readily convertible to catalytically active material by thermal treatment.Type: GrantFiled: July 5, 1988Date of Patent: August 1, 1989Assignee: Mobil Oil CorporationInventors: E. G. Derouane, R. M. Dessau, I. J. Heilweil, G. T. Kerr