Abstract: 3-Trifluorothiomethyl-2-(3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, their pharmaceutically acceptable salts certain intermediates and their preparation are disclosed. These pyridines have pharmaceutical properties such as antihypertensive activity of rapid onset.

Abstract: One process comprises the step of reacting an amount of 5-carboxy-2-pyridone directly with both a suitable chlorinating agent and a suitable fluorinating agent to selectively transform both the 5-carboxy group and the 2-positioned oxygen function of the ring. A second process comprises the steps of reacting an amount of 5-carboxy-2-pyridone with a suitable fluorinating agent to selectively transform the 5-carboxy group without altering the 2-positioned oxygen function of the ring and reacting the 5-trifluoromethyl-2-pyridone thereby formed with a suitable chlorinating agent to cause 2-chloro-5-trifluoromethylpyridine to form.

Abstract: 4a-Arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroquinolines analgesic agonists and antagonists are prepared doubly alkylating a 4-aryltetrahydropyridine with an .alpha.,.omega.-dihaloalkane.

Abstract: 3-Trifluoromethylthio-2-(3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, their pharmaceutically acceptable salts certain intermediates and their preparation are disclosed. These pyridines have pharmaceutical properties such as antihypertensive activity of rapid onset.

Abstract: New phenoxy-alkanecarboxylic acid derivatives which have a herbicidal action and which are effective in regulating plant growth are described. They correspond to the formula ##STR1## in which A is the cyano group, a carboxylic acid, a salt, ester, thioester or amide thereof,Q is a mono- to trisubstituted phenyl or pyrid-2-yl radical,R.sub.3 is hydrogen, halogen, cyano, nitro, alkyl or carbamoyl,R.sub.4 is alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, phenyl or benzyl, andX, Y and Z are each oxygen or sulfur.They can be used as selective herbicides in cereal and rice crops, or for reducing the vegetative growth, for example in soya-bean crops, and also for defoliation and desiccation in cotton or potato crops shortly before the harvesting thereof.

Abstract: The chemical compound 5-trifluoromethyl-2-pyrone and a process for preparing a 5-trifluoromethyl-2-oxy compound of the formula ##STR1## wherein A is oxygen or nitrogen bearing a hydrogen, comprising the step of reacting an amount of the 5-carboxy precursor of the compound with a suitable fluorinating agent to selectively transform the 5-carboxy group without altering the oxygen function in the 2-position of the ring.

Abstract: The present invention relates to a novel organic compound, phenyl alpha,beta-epoxy-beta-(3-trifluoromethylphenyl)ethyl ketone. This compound may be produced by:(a) condensing 3-trifluoromethylbenzaldehyde with acetophenone under basic conditions to form a substituted chalcone, and(b) epoxidation of the substituted chalcone to produce the corresponding epoxide, phenyl alpha,beta-epoxy-beta-(3-trifluoromethylphenyl)ethyl ketone.

Abstract: A sulfonanilide compounds having the formula (I): ##STR1## wherein X.sub.1 is hydrogen atom, a halogen atom, methyl group or trifluoromethyl group, X.sub.2 is hydrogen atom or a halogen atom, R.sub.1 is a (C.sub.1 -C.sub.4) alkyl group or a halo(C.sub.1 -C.sub.4) alkyl group, R.sub.2 is hydrogen atom, a (C.sub.1 -C.sub.4) alkyl group, trifluoromethyl group or nitro group, R.sub.3 is hydrogen atom, --SO.sub.2 R.sub.1 group (R.sub.1 is the same as defined above), a (C.sub.2 -C.sub.4) acyl group, a (C.sub.2 -C.sub.4) acylmethyl group, a (C.sub.1 -C.sub.4) alkyl group, a (C.sub.1 -C.sub.4) alkoxy (C.sub.1 -C.sub.4) alkyl group or a (C.sub.3 -C.sub.4) alkenyl group, R.sub.4 is hydrogen atom or a halogen atom, and n is an integer of 0 to 2; and a salt thereof, which is useful as a herbicidal component.

Abstract: A class of 1-alkyl-3-phenylpyridinium salts are useful herbicides. The compounds bear a meta-substituent on the phenyl ring and optional 4- and 5-substituents.

Abstract: Imidazolylethoxy derivatives of pyridin-5-methanols having the general formula ##STR1## and their acid addition salts are useful as antifungal and antibacterial agents.

Abstract: Compounds are prepared which correspond to the formula ##STR1## wherein X and Y represent OR', trichloromethyl, trifluoromethyl, dichloromethyl, dichlorofluoromethyl or chlorodifluoromethyl with the proviso that one of X or Y must be OR' and the other of X and Y is other than OR'; and R and R' each independently represent alkyl of 1 to 12 carbons or alkenyl of 3 or 4 carbon atoms. These compounds and compositions containing them have been found to be useful as agronomic fungicides, especially useful and valuable for the control of soil-borne plant disease organisms which attack the roots of plants.

Abstract: A cosmetic composition comprising a content of an 1-hydroxy-2-pyridone of the general formula ##STR1## in which R.sub.1 stands for hydrogen, alkyl of 1 to 17 carbon atoms, alkenyl of 2 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, bicycloalkyl of 7 to 9 carbon atoms, cycloalkyl-alkyl of 1 to 4 alkyl carbon atoms, the cycloalkyl groups being optionally substituted by alkyl groups of 1 to 4 carbon atoms, aryl, aralkyl of 1 to 4 alkyl carbon atoms, aryl-alkenyl of 2 to 4 alkenyl carbon atoms, aryloxy-alkyl or arylthio-alkyl of 1 to 4 alkyl carbon atoms, benzhydryl, phenylsulfonyl-alkyl of 1 to 4 alkyl carbon atoms, furyl or furyl-alkenyl of 2 to 4 alkenyl carbon atoms, the aryl groups being optionally substituted by alkyl of 1 to 4 carbon atoms, by alkoxy of 1 to 4 carbon atoms, by nitro, cyano or halogen atoms, R.sub.2 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl or alkinyl of 2 to 4 carbon atoms, halogen atoms or benzyl, R.sub.

Abstract: A class of 1-alkyl-3-phenylpyridinium salts are useful herbicides. The compounds bear a meta-substituent on the phenyl ring and optional 4- and 5-substituents.

Abstract: Novel iodopropargyl pyridyl and picolinyl ethers and thioethers are effective antifungal agents. They find special utility in paint for protecting finished paint films from fungal attack.

Abstract: The compounds are substituted isocytosines which are histamine H.sub.2 -antagonists. Two specific compounds of the present inventon are 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-py rimidone and 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimi done.

Abstract: Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic acitivity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.

Abstract: A class of 3-phenyl-4(1H)-pyridones and pyridinethiones are broad-spectrum herbicides. The new compounds are characterized by a small substituent on the nitrogen, and usually bear a 5-substituent chosen from a class described herein. The phenyl ring may be substituted. The compounds are effective herbicides when applied both before and after the emergence of weeds, and are particularly useful for the control of weeds in cotton and rice cropland.

Abstract: An industrially advantageous process for the manufacture of vitamin B6 (pyridoxin) from 2-methyl-3-hydroxy-4,5-bis-(halomethyl)-pyridine, wherein the starting compound is first converted in the conventional manner to the corresponding pure acetoxy compound which is reacted with an alkali metal acetate, alkaline earth metal acetate or tertiary ammonium acetate to give pyridoxin triacetate, from which pyridoxin can be liberated by hydrolysis or trans-esterification.

Abstract: Disclosed herein are substituted diphenylmethyl picolinic acids, pharmaceutically acceptable salts, amides and esters thereof. The compounds disclosed are useful as topical anti-acne agents.

Abstract: Diphenylbutyltetrahydropyridines of the following formula: ##STR1## are disclosed, in which X is hydrogen, halogen such as fluorine, chlorine or bromine, trifluoromethyl, alkoxy, nitro, amino, lower alkyl of 1 to 6 carbon atoms, aryl or substituted aryl and n is 0, 1 or 2. These compounds are useful as antipsychotics.

Abstract: A novel method for the preparation of alkyl halopyridinyloxyalkanoate compounds is disclosed, which comprises reacting a halopyridine with an alkyl alpha-hydroxy alkanoate in the presence of an alkali metal carbonate promoter.The ester products prepared from this method are useful as herbicides.