Plural Acyclic Nitrogens Bonded Directly To The Same Carbon Or Single Bonded Directly To Each Other Patents (Class 546/306)
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Patent number: 4418198Abstract: The invention is directed to the novel 2-(((substituted pyridinyl)carbonyl)amino)ethyl esters of 2-methyl-2-propenoic acid and their method of preparation. The compounds are prepared by reacting an appropriately substituted pyridinol, pyridinethiol, aminopyridine, or hydroxyalkyloxypyridine with isocyanatoethyl methacrylate in an appropriate solvent in the presence of an activating agent. These compounds may be utilized as herbicides, fungicides, or both.Type: GrantFiled: November 16, 1981Date of Patent: November 29, 1983Assignee: The Dow Chemical CompanyInventor: Chester E. Pawloski
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Patent number: 4412856Abstract: The novel compounds of the formula I are useful selective herbicides for postemergence application in crops of cereals, maize and rice.In formula I, ##STR1## A is an unsubstituted or substituted amino group, Q is a C.sub.2 -C.sub.6 alkylene bridge, Y is an oxygen or sulfur atom or an unsubstituted or substituted nitrogen atom, and Z is an unsubstituted or substituted phenyl, naphthyl or heterocyclic radical, which phenyl radical, containing the bridge member Y, can additionally carry one to four further substituents.Type: GrantFiled: May 22, 1981Date of Patent: November 1, 1983Assignee: Ciba-Geigy CorporationInventors: Hans-Georg Brunner, Rolf Schurter, Henry Szczepanski
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Patent number: 4387099Abstract: Novel 1-heterocyclyloxy- or 1-aryloxy-3-amido-alkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-(4-indolyloxy)-3-.beta.-isobutyramidoethylamino-2-propanol.Type: GrantFiled: February 12, 1982Date of Patent: June 7, 1983Assignee: Imperial Chemical Industries LimitedInventor: Leslie H. Smith
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Patent number: 4376735Abstract: Novel N-(sulphenamide)-acyl isocyanates of the formula ##STR1## in which R.sup.1 represents a thrihalogenomethyl radical andR.sup.2 represents an aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic radicalare useful as intermediates for reaction with amines to produce the corresponding fungicidally active biurets.Type: GrantFiled: December 11, 1981Date of Patent: March 15, 1983Assignee: Bayer AktiengesellschaftInventors: Engelbert Kuhle, Hermann Hagemann
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Patent number: 4372778Abstract: N-(Pyridinylaminocarbonyl)benzenesulfonamides are useful for the regulation of plant growth and as pre-emergence and post-emergence herbicides.Type: GrantFiled: May 29, 1981Date of Patent: February 8, 1983Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4358606Abstract: Novel esters of phenylalkyloxy- or phenylalkylthioacylamino acids and pyridylalkyloxy- or pyridylalkylthioacylamino acids, synthesis thereof, intermediates therefor, and the use of said esters for the control of weeds.Type: GrantFiled: June 19, 1981Date of Patent: November 9, 1982Assignee: Zoecon CorporationInventors: Shy-Fuh Lee, Clive A. Henrick
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Patent number: 4347250Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.Type: GrantFiled: September 2, 1980Date of Patent: August 31, 1982Assignee: Smith Kline & French Laboratories LimitedInventors: Graham J. Durant, Charon R. Ganellin, Geoffrey R. Owen, Rodney C. Young
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Patent number: 4345083Abstract: (1-Methyl-2-pyridinylidene) and (1-methyl-2-quinolinylidene) derivatives of guanidine having hypoglycemic activity.Type: GrantFiled: December 10, 1979Date of Patent: August 17, 1982Assignee: McNeilab, Inc.Inventor: Chris R. Rasmussen
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Patent number: 4338321Abstract: 2,6-Dihalobenzoyl 5-substituted-2-pyridinyl ureas are potent insecticides. A method of reducing a population of manure-breeding insects is also provided.Type: GrantFiled: February 11, 1981Date of Patent: July 6, 1982Assignee: Eli Lilly and CompanyInventor: John L. Miesel
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Patent number: 4331669Abstract: A compound having the formula ##STR1## wherein R is halogen, trichloromethyl, trifluoromethyl, nitro, cyano, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; X is NH, O or S and n is an integer of from 1 to 5, which is useful as a fungicide on plants and other substrates susceptible to fungicidal attack.Type: GrantFiled: June 17, 1980Date of Patent: May 25, 1982Assignee: Dow Chemical Company Limited, EnglandInventor: David P. Clifford
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Patent number: 4308054Abstract: N-(2,6-disubstituted 4-pyridyl)-N'-phenylurea compounds are plant growth regulators having potent cytokinin activity. N-(2,6-dichloro-4-pyridyl)-N'-phenylurea is useful for regulating plant growth.Type: GrantFiled: October 24, 1980Date of Patent: December 29, 1981Inventors: Yo Isogai, Soshiro Takahashi, Koichi Shudo, Toshihiko Okamoto
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Patent number: 4297498Abstract: A series of 2,6-diamino-4-tertiary-amino-pyridine 1-oxides is disclosed. Substituents in the 4-position include diethylamino, pyrrolidinyl, piperidino, morpholino, thiomorpholino, and N-methylpiperazino. Novel oxadiazolones such as 5-amino-7-(1-piperidinyl)-2H-[1,2,4]oxadiazolo[2,3-a]pyridine-2-one which are useful in the preparation of the pyridine 1-oxides are also disclosed. The compounds of this invention lower blood pressure in normotensive and hypertensive mammals and are particularly useful in the treatment of hypertensive conditions in mammals. 2,6-Diamino-4-(1-piperidinyl)pyridine 1-oxide is a representative embodiment of the invention.Type: GrantFiled: August 23, 1979Date of Patent: October 27, 1981Assignee: Mead Johnson & CompanyInventors: John E. Lawson, Ronald D. Dennis
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Patent number: 4293330Abstract: N-(Pyridinylaminocarbonyl)benzenesulfonamides are useful for the regulation of plant growth and as pre-emergence and post-emergence herbicides.Type: GrantFiled: September 29, 1980Date of Patent: October 6, 1981Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4287346Abstract: Novel cyanoguanidine derivatives, and acid addition salts thereof useful as medicines which have pharmacological actions such as anti-secretory effect, local anesthesia action and the like; and process for the preparation thereof.Type: GrantFiled: February 12, 1980Date of Patent: September 1, 1981Assignee: Eisai Co., Ltd.Inventors: Satoru Tanaka, Katsutoshi Shimada, Kazunori Hashimoto, Kiichi Ema, Koichiro Udea
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Patent number: 4285952Abstract: Bisamidines carrying one unsaturated nitrogen heterocycle-containing substituent, representative of which is 1-[N'-(2-(5-methyl-4-imidazolyl)methylthio)ethyl)guanidino]-8-[N'-methylgu anidino]octane, are histamine H.sub.2 -antagonists.Type: GrantFiled: November 13, 1979Date of Patent: August 25, 1981Assignee: Smith Kline & French Laboratories LimitedInventors: Graham J. Durant, Peter D. Miles
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Patent number: 4282363Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R.sup.2 is hydrogen, hydroxy, cyano, (lower)alkyl, (lower)alkoxy, halogen or amino; n is 2 or 3; X is NR.sup.3 or CHR.sup.3 ; R.sup.3 is cyano, nitro, SO.sub.2 Ar; or SO.sub.2 (lower)alkyl; R.sup.12 is hydrogen or (CH.sub.2).sub.p NR.sup.13 R.sup.14 ; p is an integer of from 1 to 4, inclusive; R.sup.13 and R.sup.14 each are independently hydrogen or (lower)alkyl; and Ar is phenyl or phenyl containing 1 or 2 substituents independently selected from halogen and (lower)alkyl; and nontoxic, pharmaceutically acceptable salts thereof, are potent anti-ulcer agents.Type: GrantFiled: March 10, 1980Date of Patent: August 4, 1981Assignee: Bristol-Myers CompanyInventors: Aldo A. Algieri, Ronnie R. Crenshaw
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Patent number: 4281003Abstract: 2,6-Dihalobenzoyl 5-substituted-2-pyridinyl ureas are potent insecticides. A method of reducing a population of manure-breeding insects is also provided.Type: GrantFiled: January 23, 1980Date of Patent: July 28, 1981Assignee: Eli Lilly and CompanyInventor: John L. Miesel
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Patent number: 4281004Abstract: A series of phenylguanidine base compounds and their pharmaceutically acceptable acid addition salts have been found to be active as oral hypoglycemic agents. Preferred member compounds include N,N'-diphenyl-1-pyrrolidinocarboxamidine, N-phenyl-N'-methyl-N'-phenyl-1-pyrrolidinocarboxamidine and N-phenyl-N'-(p-chlorophenyl)-1-pyrrolidinocarboxamidine, and their hydrohalide acid addition salts. Synthetic routes leading to these compounds are described.Type: GrantFiled: March 31, 1980Date of Patent: July 28, 1981Assignee: Pfizer Inc.Inventor: Jeffrey L. Ives
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Patent number: 4279639Abstract: Plant growth and suppression regulators of the N-(2-substituted-4-pyridyl)urea and thiourea type are provided, which exhibit excellent cytokinin-like activities and are thus useful for regulating plant growth in various fashions, such as acceleration of growth when used in flowering or fruiting at a controlled time when used in small amounts, and controlling compositions such as sugar, alkaloids, etc. of plants, or suppression of plant growth when used in an amount higher than optimal for growth acceleration, etc.Type: GrantFiled: August 1, 1979Date of Patent: July 21, 1981Assignees: Toshihiko Okamoto, Yo Isogai, Koichi Shudo, Susumu SatoInventors: Toshihiko Okamoto, Yo Isogai, Koichi Shudo, Soshiro Takahashi
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Patent number: 4276290Abstract: This invention relates to novel anthelmintic compounds containing an arylene or divalent heterocyclic ring whose free valences are satisfied by(1) a disubstituted phosphoryl ureido or thioureido group and(2) an amino group or a substituted amido or thioamido group,to compositions containing them, and to methods of using them for the treatment of intestinal parasites in mammals and birds.Type: GrantFiled: September 6, 1979Date of Patent: June 30, 1981Assignee: Rohm and Haas CompanyInventors: W. David Weir, Edward E. Kilbourn
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Patent number: 4269837Abstract: Novel guanylamidines and the pharmaceutically acceptable acid addition salts thereof having activity as hypoglycemic agents are disclosed.Type: GrantFiled: February 19, 1980Date of Patent: May 26, 1981Assignee: Pfizer Inc.Inventors: David S. Watt, Jeffrey L. Ives
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Patent number: 4266062Abstract: (1-Methyl-2-pyridinylidene) and (1-methyl-2-quinolinylidene) derivatives of guanidine having hypoglycemic activity.Type: GrantFiled: September 18, 1978Date of Patent: May 5, 1981Assignee: McNeilab, Inc.Inventor: Chris R. Rasmussen
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Patent number: 4260767Abstract: 2-Pyridylhydrazides useful as antiinflammatory agents.Type: GrantFiled: December 26, 1979Date of Patent: April 7, 1981Assignee: American Cyanamid CompanyInventor: John P. Dusza
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Patent number: 4256752Abstract: There are prepared compounds corresponding to the formula ##STR1## in which X is a 5-membered or 6-membered aromatic heterocyclic radical which is attached through a carbon atom to the adjacent CH.sub.2 -group and which contains from 1 to 3 nitrogen atoms or one nitrogen atom and one oxygen or sulphur atom, and which may be substituted once or twice by substituents defined hereinbelow, each R.sup.1 represents hydrogen or a C.sub.1 -C.sub.4 -alkyl group, Alk represents a C.sub.2 -C.sub.6 -alkylene chain and Ac is defined hereinbelow and their salts.Type: GrantFiled: February 13, 1979Date of Patent: March 17, 1981Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals RoesslerInventors: Walter von Bebenburg, Norbert Schulmeyer, Istvan Szelenyi
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Patent number: 4252959Abstract: Certain sulfonylhydrazines, metal complexes thereof and solutions of said compounds in essentially water-immiscible, liquid hydrocarbon solvents are disclosed. The sulfonylhydrazines have the general structural formula:R--SO.sub.2 NHNH--R.sub.1wherein R and R.sub.1 are as defined in the specification and claims hereof. Particular metal values are recovered from their aqueous solutions by using sulfonylhydrazines dissolved in essentially water-immiscible, liquid hydrocarbon solvents. The extraction process involves contacting the metal value containing aqueous solution with the solution of the sulfonylhydrazines in essentially water-immiscible, liquid hydrocarbon solvent and stripping the metal from the loaded organic phase.Type: GrantFiled: June 28, 1979Date of Patent: February 24, 1981Assignee: Henkel CorporationInventor: Ernest Spitzner
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Patent number: 4250316Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R.sup.2 is hydrogen, hydroxy, cyano, (lower)alkyl, (lower)alkoxy, halogen or amino; n is 2 or 3; X is NR.sup.3 or CHR.sup.3 ; R.sup.3 is cyano, nitro, SO.sub.2 Ar; or SO.sub.2 (lower)alkyl; R.sup.12 is hydrogen or (CH.sub.2).sub.p NR.sup.13 R.sup.14 ; p is an integer of from 1 to 4, inclusive; R.sup.13 and R.sup.14 each are independently hydrogen or (lower)alkyl; and Ar is phenyl or phenyl containing 1 or 2 substituents independently selected from halogen and (lower)alkyl; and nontoxic, pharmaceutically acceptable salts thereof, are potent anti-ulcer agents.Type: GrantFiled: November 24, 1978Date of Patent: February 10, 1981Assignee: Bristol-Myers CompanyInventors: Aldo A. Algieri, Ronnie R. Crenshaw
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Patent number: 4244950Abstract: This invention relates to new derivatives of 4-amino-3-sulfonamido-pyridine having diuretic properties.The new derivatives of pyridine may be represented by the following general formula: ##STR1## in which R.sub.1 represents hydrogen or an alkyl, cycloalkyl, carbamoyl or sulfonamido radical;R.sub.2 represents an alkyl, halogenoalkyl, cycloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, phenyl (possibly substituted), phenylalkyl, diphenylmethyl, isobornyl, furfuryl, tetrahydrofurfuryl, dialkylaminoalkyl or heterocyclic radical; or R.sub.1 and R.sub.2 form together with the nitrogen atom a saturated heterocyclic radical; andX represents an alkoxy radical, an heterocyclic amino radical, or a secondary or tertiary amino radical having its first substituent selected from hydrogen and the alkyl and alkenyl groups, and its second substituent selected from the alkyl, alkenyl, alkynyl, hydroxyalkyl, diphenylmethyl, isorbornyl, furfuryl, tetrahydrofurfuryl, phenylalkyl and heterocyclic groups.Type: GrantFiled: January 24, 1979Date of Patent: January 13, 1981Assignee: A. Christiaens Societe AnonymeInventors: Rene R. De Ridder, Andre H. Georges, Arlette Ghys, Charles L. Lapiere, Jacques E. Delarge, Leopold N. Thunus
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Patent number: 4225717Abstract: 2-Hydrazino-3-pyridinol-1-oxide hydrobromide is a useful antibacterial agent.Type: GrantFiled: July 9, 1979Date of Patent: September 30, 1980Assignee: Morton-Norwich Products, Inc.Inventor: George C. Wright
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Patent number: 4219557Abstract: The present invention is directed to 1-(2,6-dihalobenzoyl)-3-(5-substituted-2-pyridinyl)urea compounds useful as insecticides.Type: GrantFiled: August 31, 1978Date of Patent: August 26, 1980Assignee: Eli Lilly and CompanyInventor: John L. Miesel
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Patent number: 4216327Abstract: 2-(2-Acetylhydrazino)-4-nitropyridine 1-oxide is a useful antibacterial agent.Type: GrantFiled: July 9, 1979Date of Patent: August 5, 1980Assignee: Morton-Norwich Products, Inc.Inventor: George C. Wright
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Patent number: 4212875Abstract: Bisamidines carrying one unsaturated nitrogen heterocycle-containing substituent, representative of which is 1-[N'-(2-(5-methyl-4-imidazolyl)methylthio)ethyl)guanidino]-8-[N'-methyl-g uanidino]octane, are histamine H.sub.2 -antagonists.Type: GrantFiled: May 2, 1978Date of Patent: July 15, 1980Assignee: Smith Kline & French Laboratories LimitedInventors: Graham J. Durant, Peter D. Miles
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Patent number: 4203988Abstract: Compounds of the formula ##STR1## have been found to inhibit gastric secretion in mammalian species.Type: GrantFiled: September 18, 1978Date of Patent: May 20, 1980Assignee: Merck & Co., Inc.Inventors: William A. Bolhofer, Edward J. Cragoe, Jr., Jacob M. Hoffman, Jr.
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Patent number: 4193788Abstract: N-(2-Chloro-4-pyridyl)ureas represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen or alkyl, R.sub.2 represents an aromatic group, especially phenyl, which may be substituted by alkyl, alkoxyl, hydroxyl or halogen, and X is oxygen or sulfur, and acid addition salts thereof, useful as plant growth regulators, are disclosed. Method of making and using same and agricultural compositions thereof are also disclosed.Type: GrantFiled: October 2, 1978Date of Patent: March 18, 1980Inventors: Koichi Shudo, Toshihiko Okamoto, Yo Isogai, Soshiro Takahashi
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Patent number: 4183856Abstract: Urea derivatives of the formula ##STR1## (wherein Ar represents a residue of 5- or 6-membered heteroaromatic ring; R represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group; R.sup.1 represents a C.sub.1 -C.sub.6 alkyl group; and R.sup.2 represents a C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, or C.sub.1 -C.sub.6 alkoxy group) are produced by reacting an amine of the formulaAr--NH--R(wherein Ar and R have the significance given above) with a carbamoyl halogenide of the formula ##STR2## (wherein X represents a halogen atom, and R.sup.1 and R.sup.2 have the significance given above) in the presence of a Lewis acid in an inert solvent.Type: GrantFiled: April 10, 1978Date of Patent: January 15, 1980Assignee: Shionogi & Co., Ltd.Inventors: Yasuo Makisumi, Takashi Sasatani, Akira Murabayashi
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Patent number: 4182888Abstract: A series of 2,6-diamino-4-tertiary-amino-pyridine 1-oxides is disclosed. Substituents in the 4-position include diethylamino, pyrrolidinyl, piperidino, morpholino, thiomorpholino, and N-methylpiperazino. Novel oxadiazolones such as 5-amino-7-(1-piperidinyl)-2H-[1,2,4]-oxadiazolo[2,3-a]pyridine-2-one which are useful in the preparation of the pyridine 1-oxides are also disclosed. The compounds of this invention lower blood pressure in normotensive and hypertensive mammals and are particularly useful in the treatment of hypertensive conditions in mammals. 2,6-Diamino-4-(1-piperidinyl)pyridine 1-oxides is a prepresentative embodiment of the invention.Type: GrantFiled: January 30, 1978Date of Patent: January 8, 1980Assignee: Mead Johnson & CompanyInventors: John E. Lawson, Ronald D. Dennis
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Patent number: 4154941Abstract: Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the nitrogen of a phenyl-substituted urea, and their pharmaceutically acceptable salts, are active anti-arrhythmic agents.Type: GrantFiled: November 21, 1977Date of Patent: May 15, 1979Assignee: Riker Laboratories, Inc.Inventor: Elden H. Banitt
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Patent number: 4151162Abstract: Dyes for application to hair to impart rich color nuances thereto, include diazamerocyanines, the mesomeric forms thereof and the salts thereof, of the formulaA.dbd.N--N.dbd.Type: GrantFiled: July 22, 1976Date of Patent: April 24, 1979Assignee: L'OrealInventors: Gerard Lang, Andree Bugaut
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Patent number: 4149872Abstract: Compounds of the formula ##STR1## wherein A is ##STR2## in which R.sup.1 is alkyl and n is 0-1, or ##STR3## in which R.sup.2 is hydrogen, alkyl or halogen; Y is halogen or alkyl; and X is halogen, --NR.sup.3 R.sup.4 in which R.sup.3 and R.sup.4 each independently is hydrogen or alkyl; OR.sup.5 ; SR.sup.5 ; S(O)R.sup.5 or S(O).sub.2 R.sup.5, in which R.sup.5 is alkyl, are useful as herbicides.Type: GrantFiled: July 21, 1977Date of Patent: April 17, 1979Assignee: Shell Oil CompanyInventor: Kurt H. G. Pilgram
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Patent number: 4146627Abstract: The circulation provides new aminoalkylidene-amino-1,4-dihydropyridines which influence the circulatory system and are useful, for instance, as antihypertensive agents. Also included in the invention are methods for the preparation of said dihydropyridines, compositions containing them and methods for their use.Type: GrantFiled: August 26, 1977Date of Patent: March 27, 1979Assignee: Bayer AktiengesellschaftInventors: Egbert Wehinger, Friedrich Bossert, Horst Meyer, Wulf Vater, Arend Heise, Stanislav Kaada, Kurt Stoepel
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Patent number: 4139537Abstract: Cardiac arrhythmias can be treated by administering an effective amount of 3-aryloxy-1-(2-or 4-iminodihydro-1-pyridyl)-2-propanol or phamaceutically acceptable acid addition compound. Many new effective compounds of this type are disclosed.Type: GrantFiled: June 29, 1976Date of Patent: February 13, 1979Assignee: Cooper Laboratories, Inc.Inventors: Julius Diamond, Ronald A. Wohl
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Patent number: 4139624Abstract: The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(3-methoxy-2-pyridylmethylthio)ethyl)guanidino]propane and 1-[N-(2-(3-methoxy-pyridylmethylthio)ethyl)guanidino]-3-(N'-2-(5-methyl-4- imidazolylmethylthio)ethyl)guanidino]propane. The compounds of this invention are inhibitors of H-2 histamine receptors.Type: GrantFiled: July 18, 1977Date of Patent: February 13, 1979Assignee: SmithKline & French Laboratories LimitedInventors: Graham J. Durant, Charon R. Ganellin, George S. Sach
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Patent number: 4133956Abstract: Benzoylureas are prepared from a benzamide, an alkyllithium, a phenyl chloroformate, and an amine. Two reaction sequences are described. The benzoylureas obtained by the process are useful as insecticides.Type: GrantFiled: July 27, 1977Date of Patent: January 9, 1979Assignee: Eli Lilly and CompanyInventors: Riaz F. Abdulla, Norman H. Terando
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Patent number: 4127575Abstract: In the process for preparing 2,3,5-trichloropyridine, 2,3,4,5- or 2,3,5,6-tetrachloropyridine by the oxidation of the appropriate trichloro- or tetrachlorohydrazinopyridine, the improvement which comprises carrying out the oxidation with an alkaline hypochlorite in the presence of a reaction medium.Type: GrantFiled: June 20, 1977Date of Patent: November 28, 1978Assignee: The Dow Chemical CompanyInventor: Stanley D. McGregor
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Patent number: RE31244Abstract: The invention relates to a series of new compounds, to methods for preparing the compounds, to compositions containing said compounds which are useful in the human and veterinary medical practice, and to methods for treating patients suffering from certain illnesses with said compounds, the new compounds having the general formula I ##STR1## or the tautomeric forms thereof in which the R.sup.1 -substituted cyano-guanidyl radical is placed in the 2-, 3- or 4-position of the pyridine ring, and in which R.sup.1 stands for a straight or branched, saturated or unsaturated, aliphatic hydrocarbon radical having from 1 to 8 carbon atoms, a cycloalkyl or cycloalkenyl radical having from 3 to 7 carbon atoms, an aryl or an aralkyl radical, and R.sup.Type: GrantFiled: October 22, 1981Date of Patent: May 17, 1983Assignee: Leo Pharmaceutical Products Ltd. A/S (Lovens kemiske Fabrik Produktionsaktieselskab)Inventor: Hans J. Petersen