Having -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To The Six-membered Hetero Ring Patents (Class 546/310)
-
Patent number: 12017993Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.Type: GrantFiled: June 23, 2022Date of Patent: June 25, 2024Assignee: CORTEVA AGRISCIENCE LLCInventors: Jayachandran Devaraj, Nugzar Ghavtadze, Nicholas M. Irvine, Jeremy Kister, Melissa Lee, Ronald B. Leng, Rongrong [Mandy] Lin, Rong Ling, Noormohamed M. Niyaz, Abraham D. Schuitman, Aaron A. Shinkle, Siyu Tu, Gregory T. Whiteker, Chunming Zhang
-
Patent number: 11691943Abstract: The present disclosure provides a preparation method of 4-(heptafluoro-2-propyl)-2-trifluoromethylaniline and an application thereof. The preparation method comprises the following steps: reacting 2-aminobenzotrifluoride and 2-bromoheptafluoropropane in the presence of sodium formate or hydrates thereof and a SO2 reagent, so as to obtain 4-(heptafluoro-2-propyl)-2-trifluoromethylaniline. The present disclosure adds sodium formate or hydrate thereof and the SO2 reagent during the reaction of 2-aminobenzotrifluoride and 2-bromoheptafluoropropane. Under the cooperation of these two compounds, the yield of the reaction is high. And the purity of the product is high, the operation method is simple, the cost is relatively low, and the pH of the reaction doesn't need to be controlled.Type: GrantFiled: March 4, 2022Date of Patent: July 4, 2023Inventors: Chaoqun Huang, Jintao Zhu, Liangming Luo, Rong Zhang
-
Patent number: 11401242Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.Type: GrantFiled: September 18, 2019Date of Patent: August 2, 2022Assignee: Corteva Agriscience LLCInventors: Jayachandran Devaraj, Nugzar Ghavtadze, Nicholas M. Irvine, Jeremy Kister, Melissa Lee, Ronald B. Leng, Rongrong [Mandy] Lin, Rong Ling, Noormohamed M. Niyaz, Abraham D. Schuitman, Aaron A. Shinkle, Siyu Tu, Gregory T. Whiteker, Chunming Zhang
-
Publication number: 20150133301Abstract: 3-alkoxy, thioalkyl and amino-4-amino-6-(substituted)picolinic acids having a halogen, alkyl or mono-, di-tri- and tetra-substituted aryl substituents in the 6-position, and their acid derivatives, are herbicides demonstrating a broad spectrum of weed control.Type: ApplicationFiled: April 29, 2014Publication date: May 14, 2015Applicant: DOW AGROSCIENCES LLCInventors: Jeffrey B. Epp, Christian T. Lowe, James M. Renga, Paul R. Schmitzer, Joseph D. Eckelbarger, Katherine A. Guenthenspberger, Thomas L. Siddall, Carla N. Yerkes, Lindsey G. Fischer, Natalie C. Giampietro, Jeremy Kister, Joshua Roth
-
Publication number: 20150119397Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.Type: ApplicationFiled: January 8, 2015Publication date: April 30, 2015Inventors: Young K. Chen, Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
-
Publication number: 20150099888Abstract: The present invention provides a compound of general formulae A useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof.Type: ApplicationFiled: February 25, 2014Publication date: April 9, 2015Inventors: Ahmed Kamal, Mohammed Ashraf, Shaikh Faazil Bagwan, Yellamelli Valli Venkata Srikanth, Syed Mohammed Ali Hussaini, Adla Malla Reddy
-
Publication number: 20150094338Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.Type: ApplicationFiled: December 5, 2014Publication date: April 2, 2015Applicant: PFIZER INC.Inventors: Gary Erik Aspnes, Mary Theresa Didiuk, Kevin James Filipski, Angel Guzman-Perez, Jeffrey Allen Pfefferkorn, Benjamin Dawson Stevens, Meihua Mike Tu
-
Patent number: 8993772Abstract: 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation, nitrile hydrolysis, esterification, and transition metal assisted coupling.Type: GrantFiled: March 24, 2014Date of Patent: March 31, 2015Assignee: Dow AgroSciences, LLC.Inventors: Yuanming Zhu, Gregory T. Whiteker, James M. Renga, Kim E. Arndt, Gary Roth, David E. Podhorez, Scott P. West, Yang Cheng
-
Publication number: 20150072396Abstract: Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations are also provided.Type: ApplicationFiled: March 1, 2012Publication date: March 12, 2015Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Kyle Gee, Upinder Singh, Scott Grecian, Scott Clarke
-
Patent number: 8962527Abstract: A process for the preparation of solid amine salts of aromatic substituted carboxylic acid herbicides by reaction of the aromatic substituted carboxylic acid herbicide with an amine comprising reacting the aromatic substituted carboxylic acid herbicide in an ether solvent with an amine to form the amine salt and collecting the amine salt of the aromatic substituted carboxylic acid herbicide as a precipitate from the ether solvent reaction mixture wherein the ether is a dialiphatic ether comprising at least one primary aliphatic group.Type: GrantFiled: May 11, 2011Date of Patent: February 24, 2015Assignee: Nufarm Australia LimitedInventor: Eduard Kravets
-
Publication number: 20150051199Abstract: The invention provides compounds that are useful in the treatment of hepatitis C virus (HCV) infections.Type: ApplicationFiled: October 31, 2012Publication date: February 19, 2015Applicant: ASTEX THERAPEUTICS LIMITEDInventors: Andrew James Woodhead, Christopher Charles Frederick Hamlett, Gilbert Ebai Besong, Gianni Chessari, Maria Grazia Carr, Alessia Millemaggi, David Norton, Susanne Maria Saalau-Bethell, Hendrika Maria Gerarda Willems, Neil Thomas Thompson, Steven Douglas Hiscock
-
Patent number: 8952151Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.Type: GrantFiled: December 23, 2013Date of Patent: February 10, 2015Assignee: Quanticel Pharmaceuticals, Inc.Inventors: Young K. Chen, Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
-
Patent number: 8927731Abstract: 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinates by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation and transition metal assisted coupling.Type: GrantFiled: October 9, 2013Date of Patent: January 6, 2015Assignee: Dow AgroSciences, LLC.Inventors: Gregory T. Whiteker, James M. Renga, Yuanming Zhu, Christian T. Lowe, Thomas L. Siddall, David E. Podhorez, Gary Roth, Scott P. West
-
Patent number: 8912339Abstract: Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted benzene is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate. The (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate is reacted with an acid to form a 4 chloro-2-fluoro-3-substituted-phenylboronic acid. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is reacted with 2,3-dimethyl-2,3-butanediol to form 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters.Type: GrantFiled: December 20, 2012Date of Patent: December 16, 2014Assignee: Dow AgroSciences, LLC.Inventor: Jossian Oppenheimer
-
Patent number: 8889719Abstract: The invention provides novel compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation.Type: GrantFiled: March 5, 2013Date of Patent: November 18, 2014Assignee: Merck Patent GmbHInventors: Andreas Goutopoulos, Henry Yu, Benny C. Askew, Jr., Lesley Liu-Bujalski
-
Patent number: 8871943Abstract: Provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates comprising a step of converting chloropicolinoyl chlorides to fluoropicolinoyl fluorides.Type: GrantFiled: July 23, 2013Date of Patent: October 28, 2014Assignee: Dow AgroSciences, LLC.Inventors: James M. Renga, Yang Cheng, Joseck M. Muhuhi, David E. Podhorez, Gary A. Roth, Scott P. West, Gregory T. Whiteker, Yuanming Zhu
-
Publication number: 20140296533Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.Type: ApplicationFiled: June 13, 2014Publication date: October 2, 2014Applicant: DOW AGROSCIENCES LLCInventors: James M. Renga, Gregory T. Whiteker, Peter L. Johnson, Christopher Galliford
-
Publication number: 20140274696Abstract: Provided herein are 4-amino-6-(4-substituted-phenyl)-picolinic acids and their derivatives, and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylic acids and their derivatives, compositions comprising the acids and their derivatives, and methods of use thereof as herbicides.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: DOW AGROSCIENCES LLCInventors: Joseph D. ECKELBARGER, Jeffrey B. Epp, Lindsey G. Fischer, Natalie C. Giampietro, Nicholas M. Irvine, Jeremy Kister, William C. Lo, Christian T. Lowe, Jeffrey Petkus, Joshua Roth, Norbert M. Satchivi, Paul R. Schmitzer, Thomas L. Siddall, Carla N. Yerkes
-
Publication number: 20140274703Abstract: 4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinic acids and their derivatives; 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their derivatives; and methods of using the same as herbicides.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Dow AgroSciences LLCInventors: Joseph D. ECKELBARGER, Jeffrey B. EPP, Lindsey G. FISCHER, Natalie C. GIAMPIETRO, Jeremy KISTER, Jeffrey PETKUS, Joshua ROTH, Norbert M. SATCHIVI, Paul R. SCHMITZER, Thomas L. SIDDALL, Carla N. YERKES
-
Publication number: 20140256678Abstract: There are disclosed aminopyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include aminopyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.Type: ApplicationFiled: May 20, 2014Publication date: September 11, 2014Applicant: Syntrix Biosystems, Inc.Inventors: Dean Y. Maeda, John A. Zebala, Aaron D. Schuler
-
Patent number: 8809342Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.Type: GrantFiled: December 22, 2011Date of Patent: August 19, 2014Assignee: Pfizer Inc.Inventors: Gary Erik Aspnes, Mary Theresa Didiuk, Kevin James Filipski, Angel Guzman-Perez, Jeffrey Allen Pfefferkorn, Benjamin Dawson Stevens, Meihua Mike Tu
-
Publication number: 20140213591Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.Type: ApplicationFiled: December 23, 2013Publication date: July 31, 2014Applicant: Quanticel Pharmaceuticals, Inc.Inventors: Young K. Chen, Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
-
Publication number: 20140206881Abstract: 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation, nitrile hydrolysis, esterification, and transition metal assisted coupling.Type: ApplicationFiled: March 24, 2014Publication date: July 24, 2014Applicant: DOW AGROSCIENCES LLCInventors: Yuanming Zhu, Gregory T. Whiteker, James M. Renga, Kim E. Arndt, Gary Roth, David E. Podhorez, Scott P. West, Yang Cheng
-
Publication number: 20140171652Abstract: Processes for the preparation and isolation of 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid.Type: ApplicationFiled: December 12, 2013Publication date: June 19, 2014Applicant: DOW AGROSCIENCES LLCInventors: Mark V. Emonds, Robert C. Clouse
-
Publication number: 20140170058Abstract: Residual palladium is removed and recovered from 4-amino-3-halo-5-fluoro-6-(aryl)pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates by treatment with an aqueous solution containing from about 20 to about 50% of an alkali metal bisulfite at a temperature from about 60 to about 90° C. and a pH from about 3.8 to about 7.0.Type: ApplicationFiled: March 14, 2013Publication date: June 19, 2014Applicant: DOW AGROSCIENCES LLCInventors: Jossian Oppenheimer, Mark V. M. Emonds
-
Publication number: 20140171653Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.Type: ApplicationFiled: December 12, 2013Publication date: June 19, 2014Applicant: DOW AGROSCIENCES LLCInventors: James M. Renga, Gregory T. Whiteker, Peter L. Johnson, Christopher Galliford
-
Publication number: 20140171650Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a C1-C4 alkyl propiolate and a substituted methylene amine by a series of steps.Type: ApplicationFiled: December 12, 2013Publication date: June 19, 2014Applicant: DOW AGROSCIENCES LLCInventors: Natalie C. Giampietro, James M. Renga
-
Publication number: 20140171654Abstract: 4-Amino-3-chloro-6-(substituted)picolinates are prepared from difluoroacetic acid or trifluoroacetic acid, tritylamine or t-butylamine as a protecting group, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.Type: ApplicationFiled: December 12, 2013Publication date: June 19, 2014Applicant: DOW AGROSCIENCES LLCInventors: Peter L. Johnson, James M. Renga, Natalie C. Giampietro, Gregory T. Whiteker, Christopher Galliford
-
Patent number: 8754110Abstract: Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. One method comprises adding methyl isobutyl ketone to an aqueous solution comprising 4-chloro-2-fluoro-3-methoxyphenyl-boronic acid to form an organic phase comprising the 4-chloro-2-fluoro-3-methoxyphenylboronic acid and an aqueous phase. The organic phase and the aqueous phase are separated. The 4-chloro-2-fluoro-3-methoxyphenylboronic acid is reacted with methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate in methyl isobutyl ketone to produce methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate, which is deacetylated to produce methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate.Type: GrantFiled: December 28, 2012Date of Patent: June 17, 2014Assignee: Dow AgroSciences, LLC.Inventors: Jossian Oppenheimer, Mark V. M. Emonds, Christopher W. Derstine, Robert C. Clouse
-
Patent number: 8754231Abstract: 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation, nitrile hydrolysis, esterification, and transition metal assisted coupling.Type: GrantFiled: January 24, 2012Date of Patent: June 17, 2014Assignee: Dow AgroSciences, LLC.Inventors: Yuanming Zhu, Gregory T. Whiteker, James M. Renga, Gary A. Roth, David E. Podhorez, Scott P. West, Cynthia Arndt
-
Publication number: 20140142317Abstract: 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange and hydrolysis, esterification and transition metal assisted coupling.Type: ApplicationFiled: February 4, 2014Publication date: May 22, 2014Applicant: DOW AGROSCIENCES LLCInventors: James M. Renga, Yuanming Zhu, Gregory T. Whiteker, Christian T. Lowe
-
Publication number: 20140135329Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.Type: ApplicationFiled: June 20, 2013Publication date: May 15, 2014Inventors: Urs BAETTIG, Kamlesh BALA, Emma BUDD, Lee EDWARDS, Catherine HOWSHAM, Glyn Alan HUGHES, Darren Mark LEGRAND, Katrin SPIEGEL
-
Publication number: 20140128600Abstract: The present invention provides methods of synthesizing compounds of formula (1) and intermediates thereto. The present invention also provides intermediates useful in the synthesis of compounds of formula (1).Type: ApplicationFiled: May 11, 2012Publication date: May 8, 2014Applicant: Bionomics LimitedInventors: Dharam Paul, Andrew John Harvey, Bernard Luke Flynn
-
Publication number: 20140107160Abstract: The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods.Type: ApplicationFiled: October 9, 2013Publication date: April 17, 2014Applicant: Millennium Pharmaceuticals, Inc.Inventors: Paul E. Fleming, Geraldine C.B. Harriman, Zhan Shi, B. Shaowu Chen
-
Patent number: 8691852Abstract: The present disclosure relates to compounds of formula (I): or a pharmaceutically acceptable salt or N-oxide thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds of formula (I), and to their methods of use in therapy.Type: GrantFiled: August 6, 2012Date of Patent: April 8, 2014Assignee: Amirall, S.A.Inventors: Julio Cesar Castro Palomino Laria, Montserrat Erra Sola, Maria Estrella Lozoya Toribio, Eloisa Navarro Romero
-
Patent number: 8669209Abstract: Soluble granule formulations of amine salts of pyridine containing carboxylic acids with improved handling properties are provided by an improved process in which the pyridine containing carboxylic acid is partially neutralized with an amine.Type: GrantFiled: November 22, 2010Date of Patent: March 11, 2014Assignee: Dow AgroSciences, LLC.Inventors: Franklin N. Keeney, Neil A. Foster, Martin C. Logan, Maria G. Perry
-
Publication number: 20140046070Abstract: 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, reaction with hydrazine, halogenation, hydrolysis and esterification, and transition metal assisted coupling.Type: ApplicationFiled: October 9, 2013Publication date: February 13, 2014Applicant: DOW AGROSCIENCES LLCInventors: Cynthia Armdt, James M. Renga, Kim E. Arndt, Gregory T. Whiteker, Yuanming Zhu, Robert D.J. Froese
-
Publication number: 20140039196Abstract: 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinates by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation and transition metal assisted coupling.Type: ApplicationFiled: October 9, 2013Publication date: February 6, 2014Applicant: DOW AGROSCIENCES LLCInventors: Gregory T. Whiteker, Kim E. Arndt, James M. Renga, Yuanming Zhu, Christian T. Lowe, Thomas L. Siddall, David E. Podhorez, Gary Roth, Scott P. West
-
Publication number: 20140038822Abstract: Use of substituted spirocyclic sulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof for enhancement of stress tolerance in plants. The invention relates to the use of spirocyclic sulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof of the formula (I) in which the respective substituents have the meanings given in the description, for increasing stress tolerance in plants with respect to abiotic stress, and also for increasing plant growth and/or for increasing plant yield.Type: ApplicationFiled: December 27, 2011Publication date: February 6, 2014Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Jens Frackenpohl, Lothar Willms, Thomas Müller, Stefan Lehr, Pascal Von Koskull-Döring, Ines Heinemann, Christopher Hugh Rosinger, Isolde Häuser-hahn, Martin Jeffrey Hills
-
Publication number: 20140031556Abstract: Provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates comprising a step of converting chloropicolinoyl chlorides to fluoropicolinoyl fluorides.Type: ApplicationFiled: July 23, 2013Publication date: January 30, 2014Applicant: Dow AgroSciences LLCInventors: James M. Renga, Yang Cheng, Joseck M. Muhuhi, David E. Podhorez, Gary A. Roth, Scott P. West, Gregory T. Whiteker, Yuanming Zhu
-
Patent number: 8633228Abstract: A pest control agent containing a compound represented by the following Formula (1), wherein A represents a carbon atom, a nitrogen atom, or the like, K represents a non-metal atom group necessary for forming a cyclic linking group derived from a 5- or 6-membered aromatic ring, in combination with A and two carbon atoms to which A bonds, X represents a hydrogen atom, a halogen atom, or the like, n represents an integer of from 0 to 4, T represents —C(?G1)-Q1 (wherein G1 and G2 represent an oxygen atom or the like, Q1 represents a phenyl group which may have a substituent, a heterocyclic group which may have a substituent, or the like), or the like, Q2 represents a phenyl group or the like, G3 represents an oxygen atom or the like, and R1 and R2 each independently represent a hydrogen atom, a C1-C6 alkyl group, or a group represented by -L-D, or the like (provided that at least either R1 or R2 represents a group represented by -L-D); as an active ingredient exhibits an excellent effect.Type: GrantFiled: June 29, 2009Date of Patent: January 21, 2014Assignee: Mitsui Chemicals Agro, Inc.Inventors: Yumi Kobayashi, Hiroyuki Katsuta, Michikazu Nomura, Hidetaka Tsukada, Atsushi Hirabayashi, Hidenori Daido, Yusuke Takahashi, Shinichi Banba
-
Patent number: 8609855Abstract: 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinates by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation and transition metal assisted coupling.Type: GrantFiled: January 24, 2012Date of Patent: December 17, 2013Assignee: Dow AgroSciences, LLC.Inventors: Gregory T. Whiteker, James M. Renga, Yuanming Zhu, Christian T. Lowe, Thomas L. Siddall, David E. Podhorez, Gary A. Roth, Scott P. West, Cynthia Arndt
-
Publication number: 20130326735Abstract: The present invention relates to novel herbicidally active 6-(2-aminophenyl)picoline derivatives and to processes for preparation thereof. The present invention further provides for the use thereof as a herbicide, especially as a herbicide for selective control of weed plants in useful plant crops, and as a plant growth regulator alone or in combination with safeners and/or in a mixture with other herbicides.Type: ApplicationFiled: December 12, 2011Publication date: December 5, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Marco Brünjes, Uwe Döller, Hansjörg Dietrich, Michael Gerhard Hoffmann, Isolde Häuser-Hahn, Christopher Hugh Rosinger, Elmar Gatzweiler, Ines Heinemann
-
Patent number: 8598086Abstract: 3-Halo-6-(aryl)-4-iminotetrahydropicolinic acids having mono-, di- tri- and tetra-substituted aryl substituents in the 6-position, and their acid derivatives, are herbicides demonstrating a broad spectrum of weed control.Type: GrantFiled: June 7, 2010Date of Patent: December 3, 2013Assignee: Dow AgroSciences, LLC.Inventors: James M. Renga, Paul R. Schmitzer, Gregory T. Whiteker, Kim E. Arndt, Noormohamed M. Niyaz, Christian T. Lowe
-
Patent number: 8598363Abstract: The present disclosure relates to a process for manufacturing 2-[(3,5-difluoro-3?-methoxy-1,1?biphenyl-4-yl)amino]nicotinic acid.Type: GrantFiled: October 14, 2010Date of Patent: December 3, 2013Assignee: Almirall, S.A.Inventor: Maria Carmen Boix Bernardini
-
Publication number: 20130316907Abstract: A process for the preparation of solid amine salts of aromatic substituted carboxylic acid herbicides by reaction of the aromatic substituted carboxylic acid herbicide with an amine comprising reacting the aromatic substituted carboxylic acid herbicide in an ether solvent with an amine to form the amine salt and collecting the amine salt of the aromatic substituted carboxylic acid herbicide as a precipitate from the ether solvent reaction mixture wherein the ether is a dialiphatic ether comprising at least one primary aliphatic group.Type: ApplicationFiled: May 11, 2011Publication date: November 28, 2013Applicant: NUFARM AUSTRALIA LIMITEDInventor: Eduard Kravets
-
Publication number: 20130289081Abstract: A derivative of nicotinic acid N-oxide is described having formula (I): that acts as inhibitor of enzyme 3-hydroxyanthranilate-3,4-dioxygenase (3HAO), and is thus able to reduce QUIN biosynthesis in vivo under excitotoxic or pathological conditions, said compound being at the same time also chemically stable towards auto-oxidation.Type: ApplicationFiled: January 19, 2011Publication date: October 31, 2013Applicants: UNIVERSITA' DEGLI DI PARMA, UNIVERSITY OF MARYLAND, BALTIMOREInventors: Robert Schwarcz, Gabriele Costantino, Laura Amori
-
Publication number: 20130252922Abstract: The present invention relates to substituted phenoxypyridine compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: October 27, 2011Publication date: September 26, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventor: Marion Hitchcock
-
Publication number: 20130210631Abstract: 6-Amino-4-pyrimidinecarboxylic acids having alkyl, alkenyl or alkynyl substituents in the 5-position and 4-aminopicolinic acids having alkyl, alkenyl or alkynyl substituents in the 3-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.Type: ApplicationFiled: August 16, 2012Publication date: August 15, 2013Applicant: DOW AGROSCIENCES LLCInventors: Jeffrey B. Epp, Paul R. Schmitzer, Terry W. Balko, Carla N. Yerkes
-
Patent number: 8501788Abstract: This invention is generally directed to a method for recovering flunixin and flunixin analogs from pharmaceutical compositions. The recovered flunixin and analogs can be, for example, reused to make new pharmaceutical compositions and thereby reduce the need and expense of manufacturing new flunixin and flunixin analogs.Type: GrantFiled: December 12, 2008Date of Patent: August 6, 2013Assignee: Intervet Inc.Inventors: James C. Towson, Donal Coveney