Acyclic Nitrogen Bonded Directly To Chalcogen Patents (Class 546/338)
-
Patent number: 4851032Abstract: Cyclohexane-1,3-dione derivatives of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings given in the disclosure, and the use thereof for combating unwanted plants, especially Gramineae.Type: GrantFiled: February 9, 1987Date of Patent: July 25, 1989Assignee: BASF AktiengesellschaftInventors: Dieter Jahn, Rainer Becker, Norbert Goetz, Bruno Wuerzer
-
Patent number: 4837236Abstract: A heterocyclic compound of the formula: ##STR1## wherein A is an oxygen atom or a sulfur atom;B is either one of the groups: --CH.sub.2 --CHR.sup.1 -- or --CH.dbd.CR.sup.1 -- (in which R.sup.1 is a hydrogen atom or a methyl group);W is, the same or different, each a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group;X is either one of the following groups: ##STR2## (in which R.sup.2 is a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkoxy(lower)alkyl group, a hydroxyl group or a hydroxy(lower)alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group and n is an integer of 0 or 1);Z is, the same or different, each a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower)alkyl group, a halo(lower)alkoxy group, a nitro group, a methylenedioxy group or a cyano group;p is an integer of 0 to 5; andq is an integer of 0 or 1, or its salt, which is useful as a fungicide.Type: GrantFiled: September 24, 1987Date of Patent: June 6, 1989Assignee: Sumitomo Chemical Company, LimitedInventors: Naoto Meki, Hirotaka Takano
-
Patent number: 4812463Abstract: Alkane sulfonamides with an electron withdrawing function .beta. to the sulfonamide group are topically effective carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and glaucoma.Type: GrantFiled: December 10, 1987Date of Patent: March 14, 1989Assignee: Merck & Co., Inc.Inventors: Samuel L. Graham, Thomas H. Scholz
-
Patent number: 4808750Abstract: Novel fluorophenoxyphenoxypropionates and derivatives thereof possess herbicidal activity selectively in the presence of broadleaf crops. Preemergent and postemergent applications are contemplated.Type: GrantFiled: July 14, 1986Date of Patent: February 28, 1989Assignee: The Dow Chemical CompanyInventors: Richard B. Rogers, B. Clifford Gerwick, III
-
Patent number: 4803278Abstract: 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones are prepared in a three step process by(a) reducing 1-pyridyl-1,3-deketo-2-oximinoalkanes to produce 1-pyridyl-1-hydroxy-2-amine-3-ketoalkanes;(b) reacting the thus produced hydroxyaminoketone with cyanate ion to produce a 1,3-dihydro-4-hydroxy(pyridyl)methyl-2H-imidazol-2-one; and(c) oxidizing the thus produced hydroxymethyl compound to yield the desired product.Type: GrantFiled: October 7, 1986Date of Patent: February 7, 1989Assignee: Merrell Dow Pharmaceuticals, Inc.Inventors: Richard A. Schnettler, Chi-Hsin R. King
-
Patent number: 4800226Abstract: A novel dimethylsulfate quaternary salt process intermediate useful in the manufacture of the antiarrhythmic agent encainide.Type: GrantFiled: April 20, 1987Date of Patent: January 24, 1989Assignee: Bristol-Myers CompanyInventors: John L. Dillon, Richard H. Spector
-
Patent number: 4798841Abstract: Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as analgesic agents or agents for the teatment or amelioration of the symptoms of cerebral insufficiency characterized by decreased central acetylcholine production or release.Type: GrantFiled: March 31, 1987Date of Patent: January 17, 1989Assignee: Warner-Lambert CompanyInventors: David A. Downs, Walter H. Moos, David W. Moreland, Haile Tecle
-
Patent number: 4771059Abstract: The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are compounds of the formula ##STR1## and the non-toxic pharmaceutically acceptable salts thereof, wherein D is the residue of a centrally acting primary, secondary or tertiary amine and ##STR2## is an unsubstituted or substituted dihydropyridyl, dihydroquinolyl or dihydroisoquinolyl radical. The corresponding ionic pyridinium, quinolinium and isoquinolinium salts ##STR3## X.sup.-, wherein X.sup.- is the anion of a non-toxic pharmaceutically acceptable acid, are also disclosed.Type: GrantFiled: August 29, 1985Date of Patent: September 13, 1988Assignee: University of FloridaInventor: Nicholas S. Bodor
-
Patent number: 4739068Abstract: N-Phenylsulfonyl-N'-pyrimidinylureas and --N'-triazinylureas of the general formula ##STR1## and the salts of these compounds with amines, alkali metal bases and alkaline earth metal bases or with quaternary ammonium bases, have good selective herbicidal and plant growth regulating properties when applied pre- and postemergence.In the formulaR.sub.1 is hydrogen, halogen, nitro, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.5 alkenyl or C.sub.1 -C.sub.4 alkoxycarbonyl,R.sub.2 is C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy, each unsubstituted or substituted by 1 to 3 halogen atoms,R.sub.3 is halogen, hydrogen, --NR.sub.4 R.sub.5, C.sub.1 -C.sub.3 alkyl, unsubstituted or substituted by 1 to 3 halogen atoms or C.sub.1 -C.sub.4 alkoxy, or is C.sub.1 -C.sub.3 alkoxy, unsubstituted or substituted by methoxy, ethoxy, or 1 to 3 halogen atoms,R.sub.4 is hydrogen or methyl,R.sub.5 is hydrogen, C.sub.1 -C.sub.2 alkyl or methoxy,A is C.sub.1 -C.sub.4 alkylene or C.sub.Type: GrantFiled: July 21, 1986Date of Patent: April 19, 1988Assignee: Ciba-Geigy CorporationInventors: Karl Gass, Werner Fory, Willy Meyer, Werner Topfl
-
Patent number: 4727186Abstract: Phenylsulfonamides of Formula II ##STR1## wherein A is a radical of the formula --C.tbd.C--R;R is H, or an optionally substituted (i) C.sub.1 -C.sub.9 alkyl, (ii) C.sub.3 -C.sub.9 cycloalkyl, (iii) phenyl, or (iv) 5-or-6 membered heterocyclic ring;m is one or two;R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, or --Y--R.sub.5 ;R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, C.sub.1 -C.sub.4 haloalkenyl, --Y--R.sub.5, --COOR.sub.6, --NO.sub.2, or --CO--NR.sub.7 --R.sub.8 ;R.sub.5 and R.sub.6 are each independently C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.1 -C.sub.5 haloalkyl, C.sub.2 -C.sub.5 haloalkenyl, or C.sub.2 -C.sub.6 alkoxyalkyl;R.sub.7 and R.sub.8 are each independently hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, or C.sub.2 -C.sub.6 alkynyl; andY is oxygen, sulfur, sulfinyl or sulfonyl bridge; or a salt thereof.Type: GrantFiled: June 17, 1985Date of Patent: February 23, 1988Assignee: Ciba-Geigy CorporationInventors: Rolf Schurter, Werner Fury, Willy Meyer
-
Patent number: 4710508Abstract: Certain O-substituted 1-(1,2,3,6-tetrahydro-1-methyl-3-pyridinyl)ketone oximes and O-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)ketone oximes are useful as analgesic agents or agents for the treatment or amelioration of the symptoms of cerebral insufficiency characterized by decreased central acetylcholine production or release.Pharmaceutical compositions containing the compounds and methods of using the compositions in a pharmaceutical method are also disclosed.Type: GrantFiled: December 8, 1986Date of Patent: December 1, 1987Assignee: Warner-Lambert CompanyInventors: Stephen C. Bergmeier, David A. Downs, Walter H. Moos, David W. Moreland, Haile Tecle
-
Patent number: 4699652Abstract: The invention is directed to fungicidal pyridine derivatives and their N-amino salts and acid addition salts, said pyridine derivatives having the formula ##STR1## wherein R is mono-, di- or trisubstituted phenyl, wherein the substituents are the same or different and are selected from the group consisting of 1 to 3 halogen, 1 or 2 C.sub.1-3 -alkyl, 1 or 2 C.sub.1-3 -alkoxy and 1 or 2 trifluoromethyl moieties; R.sup.1 is hydrogen, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl or C.sub.2-6 -alkynyl; R.sup.2 is hydrogen; R.sup.3 is selected from the group consisting of --CO--R.sup.4, --C(OR.sup.5).dbd.CHR.sup.6, --CH(R.sup.4)OR.sup.5, --C(R.sup.4).dbd.NOR.sup.7 and ##STR2## R.sup.4 is hydrogen or C.sub.1-5 -alkyl; R.sup.5 is C.sub.1-4 -alkyl; R.sup.6 and R.sup.7 are hydrogen or C.sub.1-4 -alkyl; n is 2 or 3; or R.sup.2 taken together with R.sup.4 is equal to the group --CH.dbd.Type: GrantFiled: July 14, 1986Date of Patent: October 13, 1987Assignee: Hoffmann-La Roche Inc.Inventor: Beat Zehnder
-
Patent number: 4699984Abstract: Shown is the process which comprises heating 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid to produce a mixture of 4-(2-fluorophenyl)-2,6-dimethylpyridine and 2,4-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one, separating the components of said mixture and nitrating 4-(2-fluorophenyl)-2,6-dimethylpyridine to produce 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine. Also shown are the 3-step synthesis of 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid from 2-fluorobenzaldehyde and the five step synthesis of 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolin ecarboxylic acid, a highly potent antibacterial agent, starting with 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine. Other intermediates shown in said five step synthesis include 3-(2,6-dimethyl-4-pyridinyl)-4-fluorobenzeneamine and diethyl 4-fluoro-3-(2,6-dimethyl-4-pyridinyl)anilinomethylenemalonate.Type: GrantFiled: February 20, 1986Date of Patent: October 13, 1987Assignee: Sterling Drug Inc.Inventor: Baldev Singh
-
Patent number: 4677206Abstract: There is described a photographic system wherein development of an exposed photosensitive element with an aqueous alkaline photographic developing composition is effected in the presence of a compound which releases a quaternary in alkaline environment. Photographic products and processes utilizing such compounds are also disclosed.Type: GrantFiled: February 20, 1986Date of Patent: June 30, 1987Assignee: Polaroid Corporation, Patent Dept.Inventor: John M. Dolphin
-
Patent number: 4623381Abstract: Cyclohexane-1,3-dione derivatives of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, A and X have the meanings given in the description, and their use for controlling undesirable plant growth.Type: GrantFiled: August 10, 1983Date of Patent: November 18, 1986Assignee: BASF AktiengesellschaftInventors: Dieter Jahn, Rainer Becker, Norbert Goetz, Michael Keil, Bruno Wuerzer
-
Patent number: 4613608Abstract: Compounds of the formula ##STR1## are disclosed whereinR.sup.1 is hydrogen or lower alkyl, one of R.sup.2 and R.sup.3 is mono (or di)-nitroxy(lower)alkyl and the otherR.sup.2 and R.sup.3 is hydrogen and pharmaceutically acceptable salts thereof.Also disclosed are vasodilating compositions containing the above.Type: GrantFiled: May 8, 1985Date of Patent: September 23, 1986Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Daizo Morino, Koichi Takimoto
-
Patent number: 4610981Abstract: This invention concerns novel N-[(1H-imidazol-1-yl), (1H-1,2,4-triazol-1-yl) and (3-pyridyl)alkyl]benzenesulfonamides which are useful as inhibitors of thromboxane synthetase enzyme and/or as antihypertensive agents.Type: GrantFiled: February 11, 1985Date of Patent: September 9, 1986Assignee: American Cyanamid CompanyInventors: Joseph W. Marsico, Jr., William B. Wright, Jr.
-
Patent number: 4605656Abstract: Pyridine and pyrazine compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as hereinafter set forth and acid addition salts of these compounds, processes for their preparation, fungicidal compositions containing these compounds as the active ingredients and methods for the use of such compounds or compositions for combating fungi in agriculture and horticulture are disclosed.Type: GrantFiled: October 21, 1983Date of Patent: August 12, 1986Assignee: Hoffmann-La Roche Inc.Inventor: Franz Dorn
-
Patent number: 4540701Abstract: This invention relates to pyridylalkyl nitrate compound and a salt thereof. More particularly, it relates to a new pyridylalkyl nitrate compound and a pharmaceutically acceptable salt thereof which have vasodilating activities, to process for the preparation thereof, and to a pharmaceutical composition comprising the same for therapeutical treatment of cardiovascular disorder in human being.Type: GrantFiled: July 20, 1983Date of Patent: September 10, 1985Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Daizo Morino, Koichi Takimoto
-
Patent number: 4477453Abstract: The present invention relates to oxime ethers of the general formula I ##STR1## R.sub.2 being a pyridyl radical. The invention also relates to processes for the preparation of oxime ethers of general formula I.The compounds according to the invention may be used as medicaments particularly for their spasmolytic and anti-histamine action.Type: GrantFiled: September 24, 1982Date of Patent: October 16, 1984Assignee: UnivablotInventors: Jacques N. Astoin, Francis Lepage, Jean-Pierre M. J. Fromantin
-
Patent number: 4446321Abstract: Novel 4-aryl-or heteroaryl-2,6-bis[(substituted-amino)phenyl]pyridines which are useful as color formers in pressure-sensitive carbonless duplicating systems and thermal marking systems are prepared by reacting a 2-, 3- or 4-R.sub.1 R.sub.2 N-acetophenone with an aryl or heteroaryl aldehyde in the present of ammonia or an ammonia-releasing agent.Type: GrantFiled: June 3, 1982Date of Patent: May 1, 1984Assignee: Sterling Drug Inc.Inventors: Paul J. Schmidt, William M. Hung
-
Patent number: 4435330Abstract: Amphoteric branched sulfatobetaines of the formula ##STR1## wherein R.sub.f is perfluoroalkyl or perfluoroxyperfluoroalkyl; R.sub.1 is a direct bond or a divalent connecting group; R.sub.2, R.sub.3, and R.sub.4 are independently hydrogen or lower alkyl; R.sub.5, R.sub.6 and R.sub.7 are independently lower alkyl, and R.sub.6 may additionally represent aralkyl, and R.sub.6 and R.sub.7 taken together with the nitrogen to which they are attached may also represent piperidino or morpholino and R.sub.5, R.sub.6 and R.sub.7 taken together may also represent pyridyl, acridyl or quinolyl and salts thereof, their preparation and use as surfactants are disclosed.Type: GrantFiled: December 29, 1982Date of Patent: March 6, 1984Assignee: Ciba-Geigy CorporationInventor: Robert A. Falk
-
Patent number: 4420434Abstract: The instant invention relates to the use of ion-pair complexes derived from anionic perfluoroalkyl sulfonates, carboxylates, phosphates and phosphonates and cationic perfluoroalkyl surfactants. Such complexes are capable of reducing the surface tension of aqueous solutions dramatically even at extremely low concentrations, and are useful as wetting, spreading and leveling agents and are especially preferred as components in so-called aqueous film forming foam compositions for fighting polar and non-polar solvent and fuel fires.Type: GrantFiled: January 9, 1981Date of Patent: December 13, 1983Assignee: Ciba-Geigy CorporationInventor: Robert A. Falk
-
Patent number: 4305947Abstract: Aqueous solutions of pralidoxime salts are stabilized with hydroxylamine salts.Type: GrantFiled: August 26, 1980Date of Patent: December 15, 1981Assignee: Survival Technology, Inc.Inventor: Elliot Bartner
-
Patent number: 4294841Abstract: A drug useful as antiarhythmic, antidepressant and anxiolytic containing as an active agent a compound of the formula ##STR1## wherein X and Y are the same or different and represent hydrogen or halogen atoms, or 1-4C alkyl groups, 1-4C alkoxy groups, 1-4C alkylthio groups, CF.sub.3, OH, NH.sub.2, 1-4C monoalkylamino or amino groups substituted by a 1-4C alkylsulfonyl group, a 1-5C alkylcarbonyl group or an aroyl group and A is a CO, CHOH or CH.sub.2 group, or a salt of said compound with a pharmaceutically acceptable acid, is disclosed together with methods for the preparation thereof and its use in human therapy.Type: GrantFiled: November 27, 1979Date of Patent: October 13, 1981Assignee: PharmindustrieInventors: Alain A. Champseix, Gerard R. Le Fur
-
Patent number: 4269834Abstract: A method of combatting mycoplasma infections by treatment with copper complexes of certain phenanthroline, isoquinoline and quinazoline derivatives. A number of the complexes and ligand compounds are novel, therapeutically useful substances. Processes for their preparation are described.Type: GrantFiled: June 19, 1978Date of Patent: May 26, 1981Inventor: Wijbe T. Nauta
-
Patent number: 4263305Abstract: Novel pyridiniumaldoximes having micellar characteristics are useful in the deactivation of organophosphates. Fast and effective detoxification of areas and equipment contaminated with organophosphate pesticides and insecticides results from use of the reagents.Type: GrantFiled: March 12, 1979Date of Patent: April 21, 1981Assignee: Interx Research CorporationInventors: Joseph Epstein, Nicholas S. Bodor
-
Patent number: 4247550Abstract: The invention relates to a series of new compounds, salts thereof and to methods for the preparation of the compounds which have the general formula ##STR1## in which R.sub.1 stands for an unsubstituted or substituted phenoxy, phenylthio, benzyl, phenylsulfinyl, or anilino radical;R.sub.2 stands for a --YR.sub.2 ' radical, in which Y represents --O--, --S--, or --NH--, and R.sub.2 ' represents C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl or -alkynyl; or methyl or ethyl substituted with phenyl, furyl, thienyl or pyridyl;R.sub.3 and R.sub.4 which can be the same or different, and unsubstituted or substituted, stand for hydrogen or for a straight or branched C.sub.1 -C.sub.8 -alkyl, C.sub.2 -C.sub.8 -alkenyl or -alkynyl radical, a C.sub.5 -C.sub.7 -cycloalkyl, a phenyl, or a 5-, 6- or 7-membered heterocyclic ring system containing not more than two hetero atoms selected from the group consisting of oxygen, sulphur and nitrogen, or for a C.sub.1 -C.sub.Type: GrantFiled: December 21, 1977Date of Patent: January 27, 1981Assignee: Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab)Inventors: Peter W. Feit, Ole B. T. Nielsen, Herta Bruun, Claus A. S. Bretting
-
Patent number: 4246420Abstract: An improved method of preparing 3-(4-pyridinyl)-2-cyclohexen-1-one oxime from ethyl 5-oxo-2-[(4-pyridinyl)-carbonyl]hexanoate is a one pot sequence which comprises first heating ethyl 5-oxo-2-[(4-pyridinyl)carbonyl]hexanoate with excess sulfuric acid, neutralizing the excess acid, extracting the resulting 3-(4-pyridinyl)-2-cyclohexen-1-one with isopropyl alcohol, draining off the heavier aqueous layer, adding hydroxylamine hydrochloride to the isopropyl alcohol solution of said 2-cyclohexen-1-one, stirring the mixture at reflux, basifying the mixture and evaporating it to dryness, and isolating 3-(4-pyridinyl)-2-cyclohexen-1-one oxime from the residue. The oxime is an intermediate for preparing 3-(4-pyridinyl)aniline, in turn, an intermediate for preparing rosoxacin, an antibacterial agent.Type: GrantFiled: December 19, 1979Date of Patent: January 20, 1981Assignee: Sterling Drug Inc.Inventors: Rudolf Oesterlin, Peter A. Pareene
-
Patent number: 4243807Abstract: 4-Phenoxymethyl-piperidines of the formula ##STR1## wherein R is hydrogen, halogen, nitro, lower alkyl or lower alkoxy, in the form of the free base or an acid addition salt, are provided and they are useful as intermediates in the production of anti-hypertensive agents through condensation with (a) propyl chloride and then with an adenine, or (b) a propyl indole.Type: GrantFiled: November 1, 1976Date of Patent: January 6, 1981Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Max Thiel, Kurt Stach, deceased, by Werner Plattner, administrator
-
Patent number: 4181802Abstract: Novel 1-(heterocyclylalkyl)-1,3-dihydro-2H-benzimidazol-2-ones, wherein said heterocyclyl group is a 3-pyrrolidinyl or 3-piperidinyl group, each substituted in the 1-position with a 3-aryloxy-2-hydroxypropyl, 3-arylthio-2-hydroxypropyl or 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-2-hydroxyethyl group, said compounds having useful .beta.-adrenergic receptor blocking activity.Type: GrantFiled: December 14, 1978Date of Patent: January 1, 1980Assignee: Janssen Pharmaceutica N.V.Inventor: Ludo Kennis
-
Patent number: 4145362Abstract: A process for arylating an olefinic compound by addition of an aryl group to a double bond of said olefinic compound consisting in diazotizing an arylamine in an aqueous acidic solution comprising a lower alkanoic acid to form a solution of an aryldiazonium salt and reacting said aryldiazonium salt solution with an olefinic compound in an organic solvent in the presence of a catalytically effective amount of a copper halide.The amount of alkanoic acid is about 15 to 37% by volume of the total solvents used. The alkanoic acid is preferably acetic acid and the copper halide cuprous chloride.Type: GrantFiled: May 10, 1977Date of Patent: March 20, 1979Assignee: S.A. P R B en Neerlandais PRB N.V.Inventors: Joseph R. Brepoels, Jean-Marie Vaneghem