Halogen Attached Indirectly To The Six-membered Hetero Ring By Nonionic Bonding Patents (Class 546/346)
  • Patent number: 10253056
    Abstract: A palladium(II) complex of formula (1) or a palladium(II) complex of formula (2). Also, a process for the preparation of the complexes, and their use in carbon-carbon and carbon-heteroatom coupling reactions.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: April 9, 2019
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Thomas Colacot, Ruishan Chow, Andrew Jon Deangelis
  • Patent number: 10000453
    Abstract: Chelation directed C—H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or graphene are provided. The reactions are used to directly and regioselectively or regiospecifically functionalize specific C—H bonds, e.g. to build complexity into small molecules. Features and advantages of the present invention will be set forth in the description of invention that follows, and in part will be apparent from the description or may be learned by practice of the invention. The invention will be realized and attained by the compositions and methods particularly pointed out in the written description and claims hereof.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: June 19, 2018
    Assignee: Virginia Commonwealth University
    Inventors: Keith C. Ellis, Frank B. Gupton
  • Patent number: 9802963
    Abstract: An object of the present invention is to enable the synthesis of various fluorine-containing compounds having an organic group at both terminals of their tetrafluoroethylene structure (—CF2—CF2—). The present invention provides a fluorine-containing complex compound including a fluorine-containing organic metal compound represented by formula (1a): R1—CF2—CF2-M1??(1a) wherein M1 is a metal selected from the group consisting of copper, zinc, nickel, iron, cobalt, and tin; and R1 represents an organic group, and at least one ligand selected from the group consisting of pyridine ring-containing compounds and phosphines.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: October 31, 2017
    Assignees: DAIKIN INDUSTRIES, LTD., OSAKA UNIVERSITY
    Inventors: Kenji Adachi, Takashi Shibanuma, Takabumi Nagai, Sensuke Ogoshi, Masato Ohashi
  • Patent number: 8940185
    Abstract: To provide a novel liquid crystal compound having general physical properties necessary for the compound, namely, stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compounds, a large refractive index anisotropy, a large dielectric anisotropy and a small viscosity. The liquid crystal compound is provided as compound (1): wherein, for example, R1 is alkyl having 1 to 20 carbons; ring A1 and ring B1 are 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are a single bond, —CH2CH2—, —CH?CH— or —C?C—; L1 is fluorine; L2, Y1 and Y2 are hydrogen, fluorine or chlorine; and X1 is halogen, —C?N or alkyl having 1 to 10 carbons, and in the alkyl, arbitrary —CH2— may be replaced by —O— or —S—, and m is 1 and n is 0.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: January 27, 2015
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventor: Hiroyuki Tanaka
  • Publication number: 20140213792
    Abstract: Disclosed is a method for producing an optically active 2-arylpiperidinium salt, comprising asymmetrically hydrogenating a pyridinium salt in the presence of an iridium complex and hydrogen, the 2-arylpiperidinium salt being represented by the following general formula (1): wherein R1, R2, X, *, and m are as described in Description, the pyridinium salt being represented by the following general formula (2): wherein R1, R2, X, and m are as described in Description, and the iridium complex being represented by the following general formula (3): IrH(Z)(Q)(PP*)??(3), wherein Z, PP*, and Q are as described in Description, or the following general formula (4): [{IrH(PP*)}2(?-Z)3]Z??(4), wherein Z and PP* are as described in Description.
    Type: Application
    Filed: January 30, 2014
    Publication date: July 31, 2014
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kazushi MASHIMA, Yusuke KITA, Takuto NAGANO, Atsuhiro IIMURO, Kenta YAMAJI, Shoji HIDA, Kiyoto HORI, Hideki NARA
  • Publication number: 20140186872
    Abstract: The present invention provides compounds having the formula A: (A) or pharmaceutically acceptable salt thereof, wherein W, R1, R2 and R5 are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as cytotoxic agents towards proliferating and/or quiescent cancer stem cells, and thus are useful, for example, for the treatment of cancer.
    Type: Application
    Filed: June 6, 2012
    Publication date: July 3, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE- CNRS, UNIVERSITE DE STRASBOURG
    Inventors: Marie Feve, Maria Zeniou-Meyer, Jacques Haiech, Herve Chneiweiss, Marie-Claude Kilhoffer, Samir Mameri, Marcel Hibert
  • Publication number: 20140160384
    Abstract: The present invention relates to a smectic A phase liquid crystal material, which contains at least one heterocyclic compound. The smectic A phase liquid crystal material of the present invention may further contain at least one ester compound and an ionic compound. By using the smectic A phase liquid crystal material in a display device, a displayed image can be completely erased without any residual images after a long-term placement or a long-term drive, the contrast is generally higher than 10, and the drive voltage is generally 20 to 50 V.
    Type: Application
    Filed: September 27, 2012
    Publication date: June 12, 2014
    Inventors: Wenlei Li, Gang Sun, Huan Yin, Zhixian Tan, Huaibin Zhai
  • Publication number: 20140107073
    Abstract: Described are GCF-8 inhibitors of the formula (I), and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R5, R6, X and Z are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue.
    Type: Application
    Filed: October 4, 2013
    Publication date: April 17, 2014
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Somasekhar Bhamidipati, Marina Gelman, Pingyu Ding, Rajinder Singh, Jeffrey Clough, Todd Kinsella, Donald Payan
  • Publication number: 20140012004
    Abstract: The invention relates to palladium(0) tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results.
    Type: Application
    Filed: December 13, 2011
    Publication date: January 9, 2014
    Applicant: H4SEP KFT
    Inventors: Zoltán Daliczek, Tibor Soós, Zoltán Finta, Géza Timári, Gábor Vlád
  • Publication number: 20130281700
    Abstract: The invention relates to palladium(0)-tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results.
    Type: Application
    Filed: June 14, 2013
    Publication date: October 24, 2013
    Applicants: CHINOIN GYOGYSZER-ES VEGYESZETI TER-MEKEK GYARA ZRT, H4SEP KFT
    Inventors: Zoltán DALICZEK, Tibor SOÓS, Zoltán FINTA, Géza Timári, Gábor Vlád
  • Publication number: 20130261310
    Abstract: 3-substituted-6-trifluoromethyl pyridines are useful synthetic intermediates in the preparation of the N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines, which are useful in forming potent insecticides. Methods of forming such 3-substituted-6-trifluoromethyl pyridines are disclosed. Also disclosed are methods of using 6-trichloromethyl halogenated pyridines to form 3-substituted-6-trifluoromethyl pyridines are disclosed.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 3, 2013
    Inventors: RONALD ROSS, JR., JAMES RENGA, DOUGLAS C. BLAND, GARY A. ROTH, ALEXANDER P. FUNG, CLARK S. DAVIS
  • Publication number: 20130225815
    Abstract: A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1.
    Type: Application
    Filed: February 19, 2013
    Publication date: August 29, 2013
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: John F. Hartwig, Hiroyuki Morimoto, Patrick Fier
  • Publication number: 20130165660
    Abstract: A complex of formula (1), wherein, M is palladium or nickel, R1 and R2 are independently organic groups having 1-20 carbon atoms, or R1 and R2 are linked to form a ring structure with the phosphorus atom, R3 is selected from the group consisting of substituted and unsubstituted aryl, substituted and unsubstituted heteroaryl, and substituted and unsubstituted metallocenyl, R4 is an organic group having 1-20 carbon atoms, n is 0, 1, 2, 3, 4 or 5, X is an anionic ligand. A process for the preparation of the complex, and its use in carbon-carbon or carbon-nitrogen coupling reactions is also provided.
    Type: Application
    Filed: June 22, 2011
    Publication date: June 27, 2013
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventors: Thomas John Colacot, Carin Johansson Seechurn, Sebastien Laurent Parisel
  • Patent number: 8460851
    Abstract: A salt represented by the formula (I): wherein Q1 and Q2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, L1 represents *—CO—O-La- or *—CH2—O-Lb-, * represents a binding position to —C(Q1)(Q2)-, La and Lb independently represent a C1-C15 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO—, ring W1 represents a C2-C36 nitrogen-containing heterocyclic group in which one or more —CH2— can be replaced by —O—, and Z1? represents an organic counter ion.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: June 11, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Satoshi Yamaguchi, Koji Ichikawa
  • Publication number: 20130119310
    Abstract: To provide a novel liquid crystal compound having general physical properties necessary for the compound, namely, stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compounds, a large refractive index anisotropy, a large dielectric anisotropy and a small viscosity. The liquid crystal compound is provided as compound (1): wherein, for example, R1 is alkyl having 1 to 20 carbons; ring A1 and ring B1 are 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are a single bond, —CH2CH2—, —CH?CH— or —C?C—; L1 is fluorine; L2, Y1 and Y2 are hydrogen, fluorine or chlorine; and X1 is halogen, —C?N or alkyl having 1 to 10 carbons, and in the alkyl, arbitrary —CH2— may be replaced by —O— or —S—, and m is 1 and n is 0.
    Type: Application
    Filed: December 20, 2010
    Publication date: May 16, 2013
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventor: Hiroyuki Tanaka
  • Publication number: 20130123506
    Abstract: The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.
    Type: Application
    Filed: December 17, 2012
    Publication date: May 16, 2013
    Applicant: BAYER CROPSCIENCE AG
    Inventor: BAYER CROPSCIENCE AG
  • Patent number: 8435717
    Abstract: A sulfonic acid onium salt represented by the following formula (1) can be used as a superior radiosensitive acid generator for resist compositions. It is possible to form a good pattern by using a resist composition containing this sulfonic acid onium salt. In formula (1), R1 represents a monovalent organic group, and Q+ represents a sulfonium cation or iodonium cation.
    Type: Grant
    Filed: February 14, 2008
    Date of Patent: May 7, 2013
    Assignee: Central Glass Company, Limited
    Inventors: Yuji Hagiwara, Jonathan Joachim Jodry, Satoru Narizuka, Kazuhiko Maeda
  • Patent number: 8420812
    Abstract: A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: April 16, 2013
    Assignee: Sanofi
    Inventors: Omar Rkyek, Marc Nazare, Andreas Lindenschmidt, Jorge Alonso, Matthias Urmann, Nis Halland
  • Publication number: 20120245360
    Abstract: The present invention relates to a process for the production of trifluoromethylated unsubstituted or substituted aryl or heteroaryl compounds which comprises reacting an unsubstituted or substituted aryl or heteroaryl halide with a trifluoroacetate of formula (I) or (II), wherein R1 is hydrogen or a C1-C5 alkyl group and M an alkali metal or an ammonium ion, in the presence of and an anorganic halogenide salt or a trifluoroacetacid salt as activator compound and a catalytic combination of a copper salt with a monodentate, bidentate or tridentate aromatic or aliphatic amine or pyridine ligand.
    Type: Application
    Filed: October 26, 2011
    Publication date: September 27, 2012
    Applicant: SALTIGO GMBH
    Inventors: Alain Cotté, Matthias Gotta, Matthias Beller, Thomas Schareina, Alexander Zapf, Xiao-feng Wu
  • Publication number: 20120172392
    Abstract: Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.
    Type: Application
    Filed: March 7, 2012
    Publication date: July 5, 2012
    Inventors: LUISA M. SALTER-CID, ERIC Y. WANG, MARY T. MACDONALD, JINGJING ZHAO
  • Patent number: 8211513
    Abstract: The present invention relates to liquid-crystalline compounds having at least three fluorine-substituted benzene rings, a terminal trifluoromethyl group and at least one —CF2O— bridge. The invention also relates to liquid-crystalline media prepared therewith and to liquid-crystal display devices (LC displays) containing these media.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: July 3, 2012
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Axel Jansen, Helmut Haensel, Philipp Krattiger, Andreas Taugerbeck, Malgorzata Rillich
  • Patent number: 8168683
    Abstract: A fluorinated pyridinium cationic compound of formula (I) wherein, Rf is F(CF2)6(CH2CF2)m(CH2CH2)n—, m and n are each independently integers of 1 to 3, and R is H, C1 to C5 linear or branched alkyl, or C1 to C5 linear or branched alkoxy, having surfactant properties for lowering surface tension in an aqueous medium or solvent medium, and for use as a foaming agent.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: May 1, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Sheng Peng, Allison Mary Yake, Cheryl Lynn Casper
  • Patent number: 8153794
    Abstract: The present invention relates to a new method of cross-coupling aryl moieties comprising reacting an arylhalide with an arylboronic acid in the presence of a palladium compound and a compound comprising a di-alkylphosphine moiety.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: April 10, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Alex Sergey Ionkin
  • Publication number: 20120035372
    Abstract: The present invention relates to a process of a process for producing a 2-halogeno-6-substituted-4-trifluoromethylpyridine. Specifically, the present invention provides a process for producing a 2-halogeno-6-substituted-4-trifluoromethylpyridine represented by the formula (I): in which X is a chlorine atom, a bromine atom, or an iodine atom; R is alkyl, alkenyl, alkynyl, phenyl which may be substituted with A, benzyl which may be substituted with A, or cycloalkyl; and A is alkyl, alkoxy, a fluorine atom, or a chlorine atom, which comprises allowing a 2,6-dihalogeno-4-trifluoromethylpyridine represented by the formula (II): in which X is defined above, and a Grignard reagent represented by the formula (III): RMgX, in which R and X are defined above, to react with each other in the presence of a solvent.
    Type: Application
    Filed: April 14, 2010
    Publication date: February 9, 2012
    Applicant: ISHIHARA SANGYO KAISHA, LTD.
    Inventor: Masahiko IKEGUCHI
  • Patent number: 8106206
    Abstract: Provided is a solid luminescent quinoline compound capable of emitting light in a crystalline state, capable of changing the luminescent color not requiring modification of molecular configuration and capable of emitting light in response to external pressure such as heat, physical pressure, etc. The quinoline compound is represented by the following general formula (1): wherein R1 may be the same or different, each representing any of CF3 or CF3CF2; R2 represents any of an amino group, an N,N-dimethylamino group, an N-phenylamino group, a carbazole group, an N-methylamino group or an N-methyl-N-phenylamino group.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: January 31, 2012
    Assignee: Kyushu University, National University Corporation
    Inventors: Noboru Koga, Satoru Karasawa, Yuichiro Abe
  • Patent number: 8062768
    Abstract: Organic compounds of formula I may be used in optoelectronic devices wherein R1 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; R2 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; a is, independently at each occurrence, an integer ranging from 0-4; b is, independently at each occurrence, an integer ranging from 0-3; Ar1 is a direct bond or heteroaryl, aryl, or alkyl or cycloalkyl; Ar2 is heteroaryl, aryl, or alkyl or cycloalkyl; c is 0, 1 or 2; and n is an integer ranging from 2-4.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: November 22, 2011
    Assignee: General Electric Company
    Inventors: Yangang Liang, Shengxia Liu, Kelly Scott Chichak, Qing Ye, Jie Liu
  • Patent number: 8012547
    Abstract: The invention relates to liquid-crystalline compounds of the formula I in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, V, a, b and c have the meanings indicated in claim 1, and to liquid-crystalline media comprising at least one compound of the formula I and to electro-optical displays containing a liquid-crystalline medium of this type.
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: September 6, 2011
    Assignee: Merch Patent GmbH
    Inventors: Lars Lietzau, Markus Czanta
  • Publication number: 20110160460
    Abstract: The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, 0, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FXI0)N—(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte.
    Type: Application
    Filed: March 7, 2011
    Publication date: June 30, 2011
    Applicants: ACEP INC., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTREAL
    Inventors: Christophe Michot, Michel Armand, Michel Gauthier, Nathalie Ravet
  • Publication number: 20110092395
    Abstract: A fluorinated pyridinium cationic compound of formula (I) wherein, Rf is F(CF2)6(CH2CF2)m(CH2CH2)n—, m and n are each independently integers of 1 to 3, and R is H, C1 to C5 linear or branched alkyl, or C1 to C5 linear or branched alkoxy, having surfactant properties for lowering surface tension in an aqueous medium or solvent medium, and for use as a foaming agent.
    Type: Application
    Filed: October 15, 2009
    Publication date: April 21, 2011
    Applicant: E. I. DUPONT DE NEMOURS AND COMPANY
    Inventors: Sheng Peng, Allison Mary Yake, Cheryl Lynn Casper
  • Publication number: 20110092394
    Abstract: A composition comprising a fluorinated pyridinium cationic compound of formula (I) wherein Rf is R1(CH2CH2)n—, R1 is a C7 to C20 perfluoroalkyl group interrupted by at least one catenary oxygen atom, each oxygen bonded to two carbon atoms, n is an integer of 1 to 3, and R is H, C1 to C5 linear or branched alkyl, or C1 to C5 linear or branched alkoxy, having surfactant properties for lowering surface tension in an aqueous medium or solvent medium, and for use as a foaming agent.
    Type: Application
    Filed: October 15, 2009
    Publication date: April 21, 2011
    Applicant: E. I. DUPONT DE NEMOURS AND COMPANY
    Inventors: Sheng Peng, Allison Mary Yake, Cheryl Lynn Casper
  • Publication number: 20110028725
    Abstract: The present disclosure provides methods of synthesizing alkylating agents and methods of use.
    Type: Application
    Filed: August 17, 2010
    Publication date: February 3, 2011
    Applicant: The Queen's Medical Center
    Inventor: John L. Lim
  • Patent number: 7816016
    Abstract: Provided are complexes of the formula: where R1 is H, R4, OR4, N(R4)2 or CHAr2; R2 is H, CnF2n+1, CnF2n+1 SO2, COOR4, or CN; R3 is H, CnF2n+1, CnF2n+1SO2, COOR4, or CN; R4 is the same or different at each occurrence and is H, alkyl, or aryl, or adjacent R4 groups can join together to form a 5- or 6-membered ring, or adjacent R4 groups can join together to form a 5- or 6-membered ring; or adjacent R4 groups can join together to form a multicyclic moiety; each Ar is independently an aryl group; L? is a polydentate ligand that is not a phenylpyridine, phenylpyrimidine, or phenylquinoline; L? is a monodentate ligand, and is not a phenylpyridine, and phenylpyrimidine, or phenylquinoline; m is 1, 2 or 3; n is an integer from 1 through 20; y is 0, 1 or 2; and z is 0 or an integer from 1 through 4; with the proviso that the compound is charge neutral and the iridium is hexacoordinate.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: October 19, 2010
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Norman Herron, Mark A. Guidry, Viasceslav Petrov, Nora Sabina Radu
  • Publication number: 20100261900
    Abstract: A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.
    Type: Application
    Filed: December 23, 2009
    Publication date: October 14, 2010
    Applicant: sanofi-aventis
    Inventors: Omar RKYEK, Marc NAZARE, Andreas LINDENSCHMIDT, Jorge ALONSO, Matthias URMANN, Nis HALLAND
  • Patent number: 7786043
    Abstract: The invention relates to 2-(pyridin-2-yl)-pyrimidine compounds of general formula (I) and their use for controlling pathogenic fungi and as plant protection products that, as an active constituent, contain compounds of this type: In general formula (I), k represents 0, 1, 2, 3; m represents 0, 1, 2, 3, 4 or 5; n represents 1, 2, 3, 4 or 5; R1, independent of one another, represents halogen, OH, CN, NO2, C1-C4 alkyl, C1-C4 alkyl halide, C1-C4 alkoxy, C1-C4 alkoxy halide, C2-C4 alkenyl, C2-C4 alkynyl, C3-C8 cycloalkyl, C1-C4 alkoxy-C1-C4 alkyl, amino, phenoxy, which is optionally substituted by halogen or C1-C4 alkyl, NHR, NR2, C(Ra)?N—ORb, S(?O)pA1 or C(?O)A2, or two radicals R1 bound to adjacent carbon atoms can, together, also represent a group —O-Alk-O—, wherein Alk represents a linear or branched C1-C4 alkylene, and 1, 2, 3 or 4 hydrogen atoms can also be replaced by halogen; R2 represents C1-C4 alkyl halide, C1-C4 alkoxy, C1-C4 alkoxy halide, hydroxy, halogen, CN or NO2; whereby R2 can also represent
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: August 31, 2010
    Assignee: BASF Aktiengesellschaft
    Inventors: Wassilios Grammenos, Thomas Grote, Carsten Blettner, Markus Gewehr, Udo Hünger, Bernd Müller, Joachim Rheinheimer, Peter Schäfer, Frank Schieweck, Anja Schwögler, Ulrich Schöfl, Harald Köhle, Siegfried Strathmann, Maria Scherer, Reinhard Stierl, Jan Rether
  • Publication number: 20100016607
    Abstract: The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O2 and HF.
    Type: Application
    Filed: December 11, 2007
    Publication date: January 21, 2010
    Applicant: University of Florida Research Foundation Inc.
    Inventors: William R. Dolbier, JR., Krishna Murthy Janmanchi
  • Publication number: 20090289224
    Abstract: Organic compounds of formula I may be used in optoelectronic devices wherein R1 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; R2 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; a is, independently at each occurrence, an integer ranging from 0-4; b is, independently at each occurrence, an integer ranging from 0-3; Ar1 is a direct bond or heteroaryl, aryl, or alkyl or cycloalkyl; Ar2 is heteroaryl, aryl, or alkyl or cycloalkyl; c is 0, 1 or 2; and n is an integer ranging from 2-4.
    Type: Application
    Filed: May 22, 2008
    Publication date: November 26, 2009
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Yangang Liang, Shengxia Liu, Kelly Scott Chichak, Qing Ye, Jie Liu
  • Publication number: 20090105278
    Abstract: The invention relates to compounds for selectively inhibiting human corticosteroid syntheses CYP11B1 and CYP11B2, to the production thereof and to their use for treating hypercortisolism and diabetes mellitus or insufficiency of the heart and myocardial fibrosis.
    Type: Application
    Filed: July 21, 2005
    Publication date: April 23, 2009
    Applicant: Universitat Des Saarlandes
    Inventors: Rolf Hartmann, Sarah Ulmschneider, Ursula Muller-Viera, Rita Bernhardt, Mattas Bureik
  • Publication number: 20090076048
    Abstract: The present application describes deuterium-enriched xaliproden, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
    Type: Application
    Filed: September 15, 2008
    Publication date: March 19, 2009
    Applicant: Protia, LLC
    Inventor: Anthony W. Czarnik
  • Publication number: 20090065739
    Abstract: A compound represented by formula (1): wherein R1 is hydrogen or alkyl having 1 to 20 carbons, in which in the alkyl, arbitrary —CH2— may be replaced by —O—, —S—, —COO—, —CH?CH— or —C?C—, and arbitrary hydrogen may be replaced by halogen or alkyl having 1 to 3 carbons; ring A1, ring A2, ring A3, ring A4 and ring A5 are each independently a benzene ring, a piperidine ring, a tetrahydropyrane ring or a dioxane ring, in which in the rings, arbitrary hydrogen may be replaced by halogen, alkyl having 1 to 3 carbons, alkoxy having 1 to 3 carbons or halogenated alkyl having 1 to 3 carbons, and —CH? may be replaced by —N?; Z1, Z2, Z4, Z5 and Z6 are each independently a single bond, —COO— or —CF2O—; Z3 is a single bond or —CF2O—, and in the case where Z3 is a single bond, ring A3 is a ring represented by formula (RG-5), or L1 and L2 are both fluorine, or at least one of Z1, Z2, Z4, Z5 and Z6 is —CF2O—; L1, L2, L3 and L4 are each independently hydrogen or halogen; X1 is hydrogen, halogen, —C?N, —N?C?S, —C?C—C?N, —S
    Type: Application
    Filed: August 21, 2008
    Publication date: March 12, 2009
    Applicants: CHISSO CORPORATION, CHISSO PETROCHEMICAL CORPORATION
    Inventors: Yasuhiro HASEBA, Masayuki SAITO
  • Publication number: 20090054650
    Abstract: The present invention relates to a new method of cross-coupling aryl moieties comprising reacting an arylhalide with an arylboronic acid in the presence of a palladium compound and a compound comprising a di-alkylphosphine moiety.
    Type: Application
    Filed: October 3, 2008
    Publication date: February 26, 2009
    Inventor: Alex Sergey IONKIN
  • Patent number: 7439366
    Abstract: The present invention relates to a phenacylamine derivative of the formula (I) or a salt thereof: wherein A is alkyl, cycloalkyl, phenyl which may be substituted by Y, pyridyl which may be substituted by Y, or pyrazolyl which may be substituted by Y, R1 and R2 are each alkyl, or R1 and R2 may together form a 3- to 6-membered saturated carbocycle, R3 is hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl or COR4, X is halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkenyloxy, haloalkenyloxy, alkynyloxy, haloalkynyloxy, alkylthio, haloalkylthio, alkenylthio, haloalkenylthio, alkynylthio, haloalkynylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, dialkylaminosulfonyl, nitro, cyano, phenyl which may be substituted by Y, phenoxy which may be substituted by Y, benzyloxy which may be substituted by Y, or pyridyloxy which may be substituted by Y, and n is an integer of from 0 to 5.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: October 21, 2008
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Yuji Nakamura, Masayuki Morita, Kenji Izakura
  • Publication number: 20080255365
    Abstract: The invention relates to a microparticulate form of 1-[2-(2-naphthyl)-ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride consisting of particles for which at least 55% of the population have a diameter below 50 micrometers, and to pharmaceutical compositions in which it is present.
    Type: Application
    Filed: June 13, 2008
    Publication date: October 16, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Antoine CARON, Jean-Pierre CHAMBON, Olivier MONNIER
  • Patent number: 7189383
    Abstract: The present invention relates to Halogenated amino acid analogues for use in diagnosis, which compounds have the general formula (I) wherein: R is (C1–C6) alkyl optionally substituted with thioether or ether oxygen atom when n=0, or a substituted aromatic or heteraromatic ring when n=1–6; and m=0 or 1; and X is a halogen atom.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: March 13, 2007
    Assignee: Mallinckrodt Inc.
    Inventor: John J. R. Mertens
  • Patent number: 7002018
    Abstract: The present invention relates to a simple and efficient process for the preparation of amorphous form of torsemide. The process includes recovering amorphous torsemide from a solution thereof in a suitable solvent comprising alcohols, ketones, chlorinated hydrocarbons, esters, nitriles, cyclic ethers, and mixtures thereof, by spray drying.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: February 21, 2006
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Yatendra Kumar, Om Dutt Tyagi, Nitin Maheshwari
  • Patent number: 6943258
    Abstract: These compounds contain an oxetane functionality and a cinnamyl functionality. The oxetane functionality is homopolymerizable in reactions that can undergo cationic or anionic ring opening, and the cinnamyl functionality is polymerizable with compounds such as electron acceptor compounds. The dual functionality allows for dual cure processing. The generic structure of such compounds is in which R is a methyl or ethyl group, X and Y independently are a direct bond, or an ether, ester, or carbamate group, and Q is a divalent hydrocarbon (which may contain heteroatoms of N, O, or S), provided that X and Y will not both be direct bonds in the same molecule.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: September 13, 2005
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventor: Osama M. Musa
  • Patent number: 6919460
    Abstract: The present invention provides processes useful in the preparation of certain ?3-adrenergic receptor agonists of the structural formula the pharmaceutically acceptable salts thereof, and the hydrates of said pharmaceutically acceptable salts, wherein HET is as described herein. The invention further provides intermediates useful in the preparation of such agonists, and processes useful in the production of such intermediates.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: July 19, 2005
    Assignee: Pfizer Inc,
    Inventors: Robert J. Chambers, Robert W. Dugger, Ming Kang, Yong Tao, John W. Wong
  • Patent number: 6855850
    Abstract: To provide a practical method of manufacturing fluorine compounds in a small number of steps that can carry out fluorination reaction of substrates using easily available fluorinating agents that can be inexpensively produced industrially, and recover precursors of the fluorinating agents generated accompanying the reaction quantitatively in an easy operation, and a method of recovery and regeneration of the precursors of the fluorinating agents. N-Fluoro-quaternary-nitrogen-onium tetrafluoroborate salts represented by the general formula (1) as the fluorinating agents are used. N-Hydro-quaternary-nitrogen-onium tetrafluoroborate salts represented by the general formula (2) generated accompanying the reaction are separated and recovered from the reaction mixture by means of depositing as crystals by the addition of solvents with a low affinity to the salts to the reaction mixture after the reaction.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: February 15, 2005
    Assignee: Daikin Industries Ltd.
    Inventors: Kenji Adachi, Ginjiro Tomizawa, Satoshi Oishi
  • Patent number: 6844441
    Abstract: A process for preparing a compound of the formula: wherein n, R1, R2, R3 and X are as defined above, used as an intermediate in the synthesis of ?-adrenergic receptor agonists.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: January 18, 2005
    Assignee: Pfizer Inc
    Inventors: Robert L. Dow, Steven R. Schneider
  • Patent number: 6770463
    Abstract: There is provided a process for the preparation of a chiral insecticidal and acaricidal compound of formula I. Also provided are intermediate compounds useful in the process of the present invention.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: August 3, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: John Francis Chiarello, Brian Lee Buckwalter, Timothy Claude Barden
  • Publication number: 20040092728
    Abstract: The present invention provides a process for producing aromatic bromide or aromatic iodide from an aromatic amine derivative using nitrite ion and holodimethylsulfonium halide generated in situ from hydrobromic acid/DMSO or hydriodic acid/DMSO. The process for producing compounds of the formula (1) is disclosed (1) wherein X is bromine or iodine: Y is carbon C or nitrogen; R1, R?2?, R3, R4 which may be the same or different and are selected independently from the group consisting of a hydrogen, a hologen, a C1-C8 alkyl, a C1-C10 alkoxy, a nitro, a formyl, an aryl, a benzyl, a C2-C10 alkylcarbonyl and an arylcarbonyl, provided that adjacent groups as selected from among R1, R2, R3, R4 and R1 may combine to form a ring.
    Type: Application
    Filed: November 25, 2002
    Publication date: May 13, 2004
    Inventors: Woon Phil Baik, Jung Min Kim, Young Sam Kim, Cheol Hun Yoon, Shin Jong Kim, Seok Woo Lee