Phosphorus Attached Directly To The Five-membered Hetero Ring By Nonionic Bonding Patents (Class 548/111)
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Patent number: 9669399Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.Type: GrantFiled: May 25, 2016Date of Patent: June 6, 2017Assignee: AbbVie Inc.Inventors: Shashank Shekhar, Thaddeus S. Franczyk, David M. Barnes, Travis B. Dunn, Anthony R. Haight, Vincent S. Chan
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Publication number: 20150119365Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.Type: ApplicationFiled: December 29, 2014Publication date: April 30, 2015Inventors: Feng Tian, Qun Dang, G. Sridhar Prasad, Wenyu Li, Brett C. Bookser, Nicholas Brian Raffaele, Mark D. Erion
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Publication number: 20150099165Abstract: The invention relates to an electrolyte for a lithium-based energy storage device comprising at least one lithium salt, a solvent and at least one compound of general formula (1), and to their use in lithium-based energy storage devices.Type: ApplicationFiled: October 31, 2012Publication date: April 9, 2015Inventors: Christian Dippel, Alexandra Lex-Balducci, Martin Winter, Miriam Kunze, René Schmitz, Romek Ansgar Müller, Stefano Passerini, Nataliya Kalinovich, Gerd-Volker Röschenthaler, Tobias Böttcher
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Patent number: 8940907Abstract: The present invention relates to a process for the preparation of phosphoric esters, and to selected compounds.Type: GrantFiled: October 8, 2010Date of Patent: January 27, 2015Assignee: Merck Patent GmbHInventor: Karl Heinz Gluesenkamp
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Publication number: 20140371446Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.Type: ApplicationFiled: August 25, 2014Publication date: December 18, 2014Applicant: AbbVie Inc.Inventors: Shashank Shekhar, Thaddeus S. Franczyk, David M. Barnes, Travis B. Dunn, Anthony R. Haight, Vincent S. Chan
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Publication number: 20140329989Abstract: The present invention relates to the preparation of compounds, in particular to the preparation of compounds of formula (I), which may be used with a compound of formula (VI), or a salt thereof as intermediates for the preparation of antifungal agents, preferably micafungin (MICA) or a salt thereof.Type: ApplicationFiled: September 7, 2012Publication date: November 6, 2014Applicant: SANDOZ AGInventors: Roland Barth, Kerstin Knepper, Hubert Sturm
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Patent number: 8841487Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.Type: GrantFiled: July 15, 2011Date of Patent: September 23, 2014Assignee: AbbVie Inc.Inventors: Shashank Shekhar, Thaddeus S. Franczyk, David M. Barnes, Travis B. Dunn, Anthony R. Haight, Vincent S. Chan
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Publication number: 20140228580Abstract: The present invention relates to a method for purifying a crude PNPNH compound by metalation and re-protonation.Type: ApplicationFiled: February 10, 2014Publication date: August 14, 2014Applicants: LINDE AG, SAUDI BASIC INDUSTRIES CORPORATIONInventors: Uwe Rosenthal, Bernd H. Müller, Normen Peulecke, Marco Harff, Anina Wöhl, Andreas Meiswinkel, Heinz Bölt, Wolfgang Müller, Abdullah Mohammad Al-Qahtani, Mohammed H. Al-Hazmi, Shahid Majeed Azam
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Publication number: 20140045991Abstract: Technologies are generally described for a system and method effective to prepare a flame retardant. In one example, a method may include copolymerizing a mixture of monomers. The mixture of monomers may include at least one dicarboxylic acid monomer, at least one diamine monomer, and at least one monomer having the formula (I) wherein R1 is hydroxyl, halogen, alkoxy, or aryloxy; wherein R2 is hydroxyl, halogen, alkoxy, or aryloxy; wherein R3 is H or -L-R5; wherein R4 is H or L-R5; wherein if R3 is H, then R4 is L-R5; wherein L is alkyl, cycloalkyl, aryl, heteroaryl, or —(R6-O—R7)n-; wherein R6 is alkyl, cycloalkyl, aryl, or heteroaryl, wherein R7 is alkyl, cycloalkyl, aryl, or heteroaryl, wherein n is an integer from 1 to 12; wherein R5 is a flame retarding moiety comprising P, N, halogen, or B; and wherein q is an integer from 1 to 12.Type: ApplicationFiled: August 9, 2012Publication date: February 13, 2014Applicant: EMPIRE TECHNOLOGY DEVELOPMENT, LLCInventor: Glen Leon Brizius
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Patent number: 8642278Abstract: The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.Type: GrantFiled: November 22, 2006Date of Patent: February 4, 2014Assignee: University of South FloridaInventors: Said M. Sebti, Srikumar Chellappan, Nicholas James Lawrence
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Publication number: 20130281687Abstract: Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.Type: ApplicationFiled: March 18, 2013Publication date: October 24, 2013Inventors: ALIOS BIOPHARMA, INC., VERTEX PHARMACEUTICALS INC.
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Publication number: 20130260398Abstract: The present invention relates to the phosphohistidine analogs of the present invention which of the formula (I) and the hapten containing the residue of same. It also relates to the hapten conjugated to a carrier molecule and the isolated antibodies raised against the immunogens, said antibodies recognizing polypeptide containing a phosphorylated histidine or the phosphotriazole residue but it does not recognize an amino acid or polypeptide that is not phosphorylated or a polypeptide which is phosphorylated on amino acids other than histidine but not on histidine.Type: ApplicationFiled: September 23, 2011Publication date: October 3, 2013Applicant: THE ROCKEFELLER UNIVERSITYInventors: Tom W. Muir, Jung-Min Kee
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Patent number: 8288545Abstract: This invention features bis-amides of pyrophosphoric acid and bisphosphonic acids, their preparation, and their use in synthesis of P1,P4-dinucleoside tetraphosphates, tetraphosphonates, and related compounds.Type: GrantFiled: July 23, 2007Date of Patent: October 16, 2012Assignee: GLSynthesis Inc.Inventors: Ivan Yanachkov, George E. Wright
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Patent number: 8278456Abstract: The present invention is directed to the synthesis and stabilization of neutral molecules containing homonuclear single or multiple bonds, methods of preparation, and uses thereof.Type: GrantFiled: June 18, 2009Date of Patent: October 2, 2012Assignee: University of Georgia Research Foundation, Inc.Inventors: Gregory H. Robinson, Yuzhong Wang
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Publication number: 20120215006Abstract: The present invention relates to a process for the preparation of phosphoric esters, and to selected compounds.Type: ApplicationFiled: October 8, 2010Publication date: August 23, 2012Applicant: MERCK PATENTS GESSELLSCHAFT MIT BESCHRANKTER HAFTUNGInventor: Karl Heinz Gluesenkamp
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Patent number: 8202852Abstract: Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate analogs, or pharmaceutical compositions thereof are disclosed.Type: GrantFiled: February 3, 2010Date of Patent: June 19, 2012Assignee: XenoPort, Inc.Inventors: Noa Zerangue, Qingzhi Gao, William J. Dower
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Publication number: 20120149661Abstract: The invention relates to tetra-substituted heteroarylic compounds of the formula (I) wherein X1, X3 and X4 are independently C or N, Y is C—H, N—H or N, wherein the total number of nitrogen atoms represented by X1, X3, X4 and Y is 1 or 2; rings A and B are independently selected from phenyl or pyridyl; R1, R4, R?, R?, n and m are as defined herein. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.Type: ApplicationFiled: August 24, 2010Publication date: June 14, 2012Applicant: NOVARTIS AGInventors: Guido Bold, Pascal Furet, Francois Gessier, Joerg Kallen, Joanna Hergovich Lisztwan, Keiichi Masuya, Andrea Vaupel
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Publication number: 20120022252Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.Type: ApplicationFiled: July 15, 2011Publication date: January 26, 2012Applicant: ABBOTT LABORATORIESInventors: Shashank Shekhar, Thaddeus S. Franczyk, David M. Barnes, Travis B. Dunn, Anthony R. Haight, Vincent S. Chan
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Publication number: 20110269968Abstract: Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-containing compounds simultaneously.Type: ApplicationFiled: July 15, 2011Publication date: November 3, 2011Applicant: Trace Bio Analytics, Inc.Inventors: Poguang Wang, Guodong Li, Roger W. Geise
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Patent number: 8044091Abstract: 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.Type: GrantFiled: November 21, 2008Date of Patent: October 25, 2011Assignee: Idenix Pharmaceuticals, Inc.Inventors: Richard Storer, Cyril Dousson, Francois-Rene Alexandre, Arlene Roland
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Patent number: 7964736Abstract: Cyclocreatine phosphate can be prepared in large quantities from inexpensive starting materials to afford a stable product.Type: GrantFiled: December 29, 2005Date of Patent: June 21, 2011Assignee: Nour Heart, Inc.Inventors: Ahmed Farghaly, Elgebaly A. Salwa
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Patent number: 7744838Abstract: One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acidic group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronsted-acidic group to catalyze a Bronsted-acid-catalyzed chemical reaction. A third aspect of the present invention relates to ionic liquids comprising a pendant nucleophilic group, e.g., an amine. Still another aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to catalyze a nucleophile-assisted chemical reaction. A fifth aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to remove a gaseous impurity, e.g., carbon dioxide, from a gas, e.g., sour natural gas.Type: GrantFiled: April 24, 2007Date of Patent: June 29, 2010Assignee: University of South AlabamaInventor: James H. Davis, Jr.
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Publication number: 20100137255Abstract: Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate analogs, or pharmaceutical compositions thereof are disclosed.Type: ApplicationFiled: February 3, 2010Publication date: June 3, 2010Applicant: XenoPort, Inc.Inventors: Noa Zerangue, Qingzhi Gao, William J. Dower
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Publication number: 20100041895Abstract: The present invention is directed to the synthesis and stabilization of neutral molecules containing homonuclear single or multiple bonds, methods of preparation, and uses thereof.Type: ApplicationFiled: June 18, 2009Publication date: February 18, 2010Applicant: University of Georgia Research Foundation, Inc.Inventors: Gregory H. Robinson, Yuzhong Wang
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Publication number: 20090299048Abstract: This invention features bis-amides of pyrophosphoric acid and bisphosphonic acids, their preparation, and their use in synthesis of P1,P4-dinucleoside tetraphosphates, tetraphosphonates, and related compounds.Type: ApplicationFiled: July 23, 2007Publication date: December 3, 2009Applicant: GLSynthesis IncInventors: Ivan Yanachkov, George E. Wright
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Patent number: 7589210Abstract: The present invention involves new nitrons carrying a positive charge, useful in trapping of free radicals and especially the superoxide radical, of general formula:Type: GrantFiled: October 24, 2006Date of Patent: September 15, 2009Assignees: Universite de Provence, Centre National de la Recherche Scientifique (CNRS)Inventors: Paul Tordo, Jean-Pierre Bernard Finet, Florence Nathalie Laurence Chalier, Olivier Ouari, Micael Hardy
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Patent number: 7589081Abstract: The present invention relates to novel nitrogen-containing monodentate phosphane ligands of formula (I) and to their use in catalytic reactions, especially in the improvement of haloaromatic compounds.Type: GrantFiled: May 3, 2004Date of Patent: September 15, 2009Assignee: DEGUSSA GmbHInventors: Alexander Zapf, Mark Sundermeier, Ralf Jackstell, Matthias Beller, Thomas Riermeier, Axel Monsees, Uwe Dingerdissen
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Publication number: 20090215185Abstract: Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-compounds simultaneously.Type: ApplicationFiled: June 21, 2006Publication date: August 27, 2009Inventors: Poguang Wang, Guodong Li, Roger W. Giese
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Patent number: 7560555Abstract: A process for the preparation of a compound of formula R1—Y1—P(NR2R3)2 is provided. The process comprises reacting a compound of formula PX3 with a compound of formula HNR2R3 to form a compound of formula X—P(NR2R3)2; and reacting the compound of formula X—P(NR2R3)2 with a compound of formula R1—Y1—H in the presence of a hydrocarbon solvent to form the compound of formula R1—Y1—P(NR2R3)2. R1 represents a phosphorus protecting group; R2 and R3 each independently represent an alkyl, prefer-ably a C1-6alkyl, group, or R2 and R3 are joined, together with the N to which they are attached, to form a 5-7 membered ring; Y1 represents O or S, preferably O; and X represents a halogen, preferably Cl. The preferred solvent is toluene.Type: GrantFiled: December 16, 2003Date of Patent: July 14, 2009Assignee: Avecia Biotechnology Inc.Inventors: Jonathan Mark Hardy, Stephen Edward Dinizo
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Publication number: 20090143597Abstract: Novel chemical compounds of the general formula K+A?, in which K+is a 5- or 6-membered heterocyclic ring having 1-3 hetereo atoms, which can be independently N, S, or O; with the proviso that at least one of the hetereo atoms must be a quaternized nitrogen atom having a —R?CN substituent, wherein R? is alkyl (C1 to C12); the heterocyclic ring having up to 4 or 5 substituents independently chosen from the moieties: (i) H; (ii) halogen or (iii) alkyl (C1 to C12), which is unsubstituted or partially or fully substituted by further groups, preferably F, Cl, N(CnF(2n+1?x)Hx)2, O(CnF(2n+1?x)Hx), SO2(CnF(2n+1?x)Hx)2 or CnF(2n+1?x)Hx where 1<n<6 and 0<x<13; and (iv) a phenyl ring which is unsubstituted or partially or fully substituted by further groups, preferably F, Cl, N(CnF(2n+1?x)Hx)2, O(CnF(2n+1?X)Hx), SO2(CnF(2n+1?x)Hx)2 or CnF(2n+1?x)Hx where 1<n<6 and 0<x?13; and A? is any anion that provides a salt with a low melting point, below about 100° C.Type: ApplicationFiled: August 25, 2004Publication date: June 4, 2009Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNEInventors: Paul Dyson, Dongbin Zhao, Zhaofu Fei
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Patent number: 7534809Abstract: 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.Type: GrantFiled: September 16, 2005Date of Patent: May 19, 2009Assignee: Idenix Pharmaceuticals, Inc.Inventors: Richard Storer, Cyril Dousson, Francois-Rene Alexandre, Arlene Roland
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Publication number: 20090105279Abstract: The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.Type: ApplicationFiled: July 19, 2007Publication date: April 23, 2009Inventors: Carina E. Cannizzaro, James M. Chen, Manoj C. Desai, Michael L. Mitchell, Sundaramoorthi Swaminathan, Lianhong Xu, Zheng-Yu Yang
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Publication number: 20080242639Abstract: Cyclocreatine phosphate can be prepared in large quantities from inexpensive starting materials to afford a stable product.Type: ApplicationFiled: December 29, 2005Publication date: October 2, 2008Inventors: Farghaly Ahmed, Salwa A. Elgebaly
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Publication number: 20080112866Abstract: One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acidic group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronsted-acidic group to catalyze a Bronsted-acid-catalyzed chemical reaction. A third aspect of the present invention relates to ionic liquids comprising a pendant nucleophilic group, e.g., an amine. Still another aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to catalyze a nucleophile-assisted chemical reaction. A fifth aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to remove a gaseous impurity, e.g., carbon dioxide, from a gas, e.g., sour natural gas.Type: ApplicationFiled: April 24, 2007Publication date: May 15, 2008Applicant: University of South AlabamaInventor: James Hillard Davis
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Publication number: 20080009465Abstract: Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n-Z-(CH2)m—PO(OR7)(OR8), —(CH2)nZ-(CH2)m—PO(OR7)Rg, —(CH2)n-Z-(CH2)m—OPO(OR7)Rg, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.Type: ApplicationFiled: June 28, 2007Publication date: January 10, 2008Inventors: Denis E. Ryono, Peter T.W. Cheng, Scott A. Bolton, Sean Chen, Yan Shi, Wei Meng, Joseph A. Tino, Hao Zhang, Richard B. Sulsky
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Publication number: 20070265321Abstract: Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.Type: ApplicationFiled: May 7, 2007Publication date: November 15, 2007Inventors: Robert M. Burk, David W. Old, Todd Gac
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Patent number: 7173138Abstract: Pnicogen chelate compounds which have two pnicogen-containing groups joined to one another via a xanthene-like or triptycene-like molecular skeleton and in which at least one pyrrole group is covalently bound via its nitrogen atom to each pnicogen atom form complexes with metals of transition group VIII which are useful as catalysts for the hydroformylation of olefins.Type: GrantFiled: March 28, 2002Date of Patent: February 6, 2007Assignee: BASF AktiengesellschaftInventors: Wolfgang Ahlers, Rocco Paciello, Dieter Vogt, Peter Hofmann
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Patent number: 7109346Abstract: N-Phenylpyrrolebisphosphines of the formula I metal complexes of these N-phenylpyrrolebisphosphines and their use in metal-catalyzed reactions.Type: GrantFiled: December 12, 2001Date of Patent: September 19, 2006Assignee: OXENO Olefinchemie GmbH & Co. KGInventors: Matthias Beller, Ralf Jackstell, Holger Klein, Detlef Heller, Hans-Joachim Drexler, Klaus-Diether Wiese, Dirk Roettger
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Patent number: 7105556Abstract: Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2, X3 and X4 are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.Type: GrantFiled: May 22, 2002Date of Patent: September 12, 2006Assignee: Bristol-Myers Squibb CompanyInventors: Peter T. Cheng, Yoon Jeon, Wei Wang
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Patent number: 7081533Abstract: The present invention concerns novel unsymmetrical chiral diphosphines of a mixed aliphatic-aromatic type and processes for synthesizing them, complexes of these compounds and their use as catalysts.Type: GrantFiled: August 17, 2001Date of Patent: July 25, 2006Assignee: Degussa AGInventors: Boris E Bosch, Axel Monsees, Uwe Dingerdissen, Paul Knochel, Eike Hupe
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Patent number: 6927216Abstract: The present application describes novel cyclic sulfonyl derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa, and S(O)p, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease inhibitors.Type: GrantFiled: September 17, 2001Date of Patent: August 9, 2005Assignee: Bristol-Myers Squibb Pharma CompanyInventors: Robert J. Cherney, Bryan W. King
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Patent number: 6919322Abstract: Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.Type: GrantFiled: March 7, 2001Date of Patent: July 19, 2005Assignee: Metabasis Therapeutics, Inc.Inventors: Brett C. Bookser, Qun Dang, K. Raja Reddy
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Patent number: 6806378Abstract: The present invention provides a catalyst system and a process for the preparation of a nonracemic chiral alcohol by hydrogenation of a ketone using the catalyst system, wherein the catalyst system comprises ruthenium, a nonracemic chiral diphosphine ligand, an amino-thioether ligand, and a base.Type: GrantFiled: May 21, 2002Date of Patent: October 19, 2004Assignee: DSM N.V.Inventors: Charles E. Tucker, Qiongzhong Jiang
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Publication number: 20040116702Abstract: The invention relates to acyl- or bisacylphosphine derivatives according to formula (1), wherein: Y represents O, S, NR3, N—OR3 or N—NR3R54; Z represents O, S, NR3, N—OR3, N—NR3R4 or a free electron pair; Het1 and Het2, independent of one another, represent O, S and/or NR5, and; the other radicals have the meanings as cited in the description. The invention also relates to methods for producing these derivatives and to the use thereof.Type: ApplicationFiled: October 14, 2003Publication date: June 17, 2004Inventors: Ralf Noe, Andreas Henne, Matthias Maase
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Publication number: 20040077855Abstract: Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.Type: ApplicationFiled: August 28, 2003Publication date: April 22, 2004Inventors: Kevin J. Duffy, Juan I Luengo, Antony N Shaw
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Publication number: 20030232991Abstract: Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include (R,S,S,R)-DIOP*. The ruthenium complex reduces enamide to the corresponding amine with up to 99% enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation, hydride transfer, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, hydrocarboxylation, isomerization, allylic alkylation, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition and epoxidation reactions.Type: ApplicationFiled: April 10, 2003Publication date: December 18, 2003Applicant: The Penn State Research FoundationInventor: Xumu Zhang
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Patent number: 6627758Abstract: Compositions and methods are described for hydrating terminal alkynes catalytically in anti-Markovnikov fashion. The compositions comprise a transition metal complex including at least one organic ligand having at least two heteroatoms, wherein the heteroatoms are directly bonded or located one atom away. Preferably, at least one of the heteroatoms is nitrogen, which is typically provided as part of a heterocyclic ring. Other preferred heteroatoms include S, P, N, As or Se. A particularly preferred catalyst employs a P-linked imidazole ligand bound to Ru. Such complexes have a controlled adaptable proton transfer ability and/or a hydrogen bonding ability making them particularly useful as chemical reaction facilitators.Type: GrantFiled: February 16, 2001Date of Patent: September 30, 2003Assignee: San Diego State University FoundationInventor: Douglas Bryan Grotjahn
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Publication number: 20030125565Abstract: The present invention relates to novel imidazolidine derivatives of the formula I, 1Type: ApplicationFiled: May 20, 2002Publication date: July 3, 2003Inventors: Volkmar Wehner, Hans Ulrich Stilz, Wolfgang Schmidt, Dirk Seiffge
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Patent number: 6586415Abstract: Novel triazolinethilone-phosphoric acid derivatives of the formula in which R1, R2, R3 and Q are each as defined in the description and their metal salt complexes, a process for preparing the novel substances and their use as microbicides in crop protection and in the protection of materials are described.Type: GrantFiled: November 15, 2001Date of Patent: July 1, 2003Assignee: Bayer AktiengesellschaftInventors: Stefan Hillebrand, Bernd-Wieland Krüger, Manfred Jautelat, Klaus Stenzel, Astrid Mauler-Machnik, Stefan Dutzmann
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Patent number: 6586357Abstract: Chiral diphosphines constituted by an aromatic pentatomic biheterocyclic system, suitable to act as chiral ligands, complexes between said diphosophines and transition metals, and their utilization as chiral catalysts in sterocontrolled reactions, such as diastereo- and enantioselective reduction reactions. Process for the preparation of said chiral diphosophines and process for the preparation of said complexes and for their utilization as chiral catalysts in sterocontrolled reactions.Type: GrantFiled: August 24, 2001Date of Patent: July 1, 2003Assignee: Chemi S.p.A.Inventors: Patrizia Antognazza, Tiziana Benincori, Elisabetta Brenna, Edoardo Cesarotti, Francesco Sannicolo′, Licia Trimarco