Abstract: The present invention provides a compound having excellent control efficacy against pests, especially Lepidoptera pests. A compound represented by formula (1) has excellent control efficacy against pests, especially Lepidoptera pests.

Abstract: Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.

Abstract: Embodiments of substrates and processes for chromogenic detection, and in particular pyrazolyl dihydrogen phosphate compounds, are disclosed.

Abstract: The present invention relates to pyrazole derivatives of the formula (I), ##STR1## wherein R.sup.1, R.sup.2, X.sup.1, X.sup.2, X.sup.3, X.sup.4, X.sup.5, X.sup.6, X.sup.7, X.sup.8, p and n are as defined on claim 1, or a salt thereof, and herbicides containing them as active ingredients.

Abstract: Oligonucleotides having a low molecular weight tail molecules joined to the 3' terminus of the oligonucleotide via a linking molecule of the structure:Z is ##STR1## wherein ##STR2## m and m' are positive integers less than 11, n is 0 or 1 and Q is a connecting group, are synthesized by selectively reacting three independent functional groups on the linking molecule, i.e., an amine, a primary hydroxyl and a secondary hydroxyl, in a stepwise manner. A tail molecule R is first connected to the amino functionality of the linking molecule. Next the linking molecule-tail molecule combination is attached to a solid state support via the secondary hydroxyl group. The oligonucleotide is systematically stepwise synthesized beginning on the primary hydroxyl group followed by release of the oligonucleotide having the low molecular weight tailed joined to its 3' terminus from the solid state support.

Abstract: There are provided new 3-hydroxy-4-aryl-5-oxo-pyrazoline derivatives of the formula (I) ##STR1## The new 3-hydroxy-4-aryl-5-oxo-pyrazoline derivatives of the formula (I) have a particularly pronounced activity against animal pests, in particular against insects and arachnids, and against weeds.

Abstract: Compounds of formula ##STR1## wherein Y, R.sub.1, R.sub.2, Het, X and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compounds of formula I are useful in the treatment of cardiovascular diseases.

Abstract: A phosphorylating agent represented by the following general formula [1]: ##STR1## wherein R represents a protective group of the phosphoric acid; and X represents a heterocyclic residue represented by the following general formula [2]: ##STR2## wherein Y represents a single bond or an oxygen or sulfur atom; Z represents a heterocyclic nucleus comprising at least one nitrogen atom as a ring-forming element and may be condensed with another aromatic ring; and W represents one or more substituents other than a hydrogen atom. The phosphorylating agent is stable, can rapidly proceed phosphodiester bond-forming reactions in good selectivity under mild conditions and thus makes it possible to perform a reaction even in a relatively large scale.

Abstract: A novel glycerol derivative which is effective to reduce blood pressure has the formula: ##STR1## wherein R.sup.1 is an alkyl group having 10-22 carbon atoms, R.sup.2 is lower acyl, benzoyl, aryl, mono-, di- or triarylalkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is substituted or unsubstituted alkylene containing 1-4 carbon atoms, l is 0 or 1; Y is a nitrogen-containing heterocyclic group or a nitrogen-containing bridged heterocyclic group (--(Q).sub.l -- is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where l is 0; and each of R.sup.5, R.sup.6 and R.sup.7 is hydrogen, lower alkyl, aryl or aralkyl.

Abstract: Disclosed are imidazole derivatives represented by formula [I]: ##STR1## wherein R is a hydrogen atom or ##STR2## wherein R.sup.2 is a hydrogen atom or a hydroxy protecting group, R.sup.2 protecting either a single hydroxy or two hydroxies together when R.sup.2 is a hydroxy protecting group, and R.sup.3 is a hydrogen atom or OR.sup.2 ; A is CONH.sub.2 or CN; and R.sup.1 is a hydrogen atom, lower alkyl, hydroxy lower alkyl, or phenyl.Also disclosed are six processes for producing these novel compounds among which a typical process comprises reacting a starting imidazole compound having a halogen at the 5-position thereof with an acetylene derivative to alkynylate the 5-position.Furthermore, the compounds having remarkable antitumor activities and therefore can provide novel antitumor agents.

Abstract: Novel alkoxycarbonylalkylphospholipids, alkylaminocarbonylalkylphospholipids, processes for the preparation thereof, and methods for treating inflammation utilizing compounds or compositions thereof are disclosed.

Abstract: A pyrazole derivative of the formula I ##STR1## wherein A is C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl or C.sub.2 -C.sub.4 alkynyl; B is hydrogen, C.sub.1 -C.sub.3 alkyl, halogen, C.sub.1 -C.sub.3 haloalkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkylthio, C.sub.2 -C.sub.4 alkoxyalkyl, C.sub.2 -C.sub.4 alkylthioalkyl or C.sub.2 -C.sub.4 alkoxycarbonyl; X is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halogen, nitro, cyano, etc.; Y is --OR.sup.1 (wherein R.sup.1 is C.sub.3 -C.sub.8 cycloalkyl, etc), --O--L--O--R.sup.1 (wherein L is C.sub.1 -C.sub.6 alkylene which may be substituted by C.sub.1 -C.sub.3 alkyl), --O--L--OH, --O--L--O--L--O--R.sup.2 (wherein R.sup.2 is hydrogen, C.sub.1 -C.sub.6 alkyl group, etc.), --O--L--R.sup.3 (wherein R.sup.3 is phenyl which may be substituted by C.sub.1 -C.sub.3 alkyl, etc.), --O--M (wherein M is a 3- to 6-membered alicyclic group), --O--L--M, --O--L--NR.sup.4 R.sup.5 (wherein each of R.sup.4 and R.sup.5 is hydrogen or C.sub.1 -C.sub.6 alkyl, or R.sup.

Abstract: The invention describes novel 3-cyano-4-sulfenylated-5-alkoxy-1-arylpyrazoles of general formula (I) ##STR1## wherein typically preferred substituents are: R is C.sub.1 to C.sub.4 alkyl fully substituted by halogen;R.sub.1 is C.sub.1 to C.sub.4 alkyl, C.sub.3 to C.sub.6 alkenyl and alkynyl or aralkyl (each of which may be optionally substituted), dialkylaminocarbonyl or a group --P(=X)(Oalkyl)(Salkyl) wherein X is oxygen or sulfur;R.sub.2, R.sub.3, R.sub.5 and R.sub.6 are each hydrogen or halogen;R.sub.4 is CF.sub.3, OCF.sub.3, SCF.sub.3, SOCF.sub.3, SO.sub.2 CF.sub.3, OCHF.sub.2, halogen or alkyl; and n is 0, 1 or 2.The invention further relates to intermediates and processes to make the compounds and to compositions thereof and to methods of control of arthopod (especially insect) nematode, helminth, and protozoan pests.

Abstract: A pyrazole derivative having the formula: ##STR1## where A, B, X, Y, Z and Q are described below.

Abstract: 5-hydroxypyrazole derivatives and the insecticidal compositions containing the same are provided. Said derivatives exhibit excellent insecticidal effects and bioactivities, and also they have a broad-spectrum of use.

Abstract: In the preparation of a (thiono)phosphoric ester of the formula ##STR1## in which X represents oxygen or sulphur,R and R.sup.1 are identical or different and represent alkyl, andR.sup.2 represents optionally substituted aryl or represents optionally substituted hetaryl having at least one nitrogen atom,wherein a hydroxyl derivative of the formulaR.sup.2 --OHor an ammonium, alkali metal or alkaline earth metal salt thereof is reacted with a (thiono)phosphoric halide of the formula ##STR2## in which Hal represents halogen,the improvement which comprises effecting the reaction in the presence of a bicyclic organic amine as catalyst. Advantageously the reaction is effected in a diluent in the presence of potassium carbonate as an acid acceptor at 20.degree. to 100.degree. C., and 0.8 to 1.5 mols of the halide and 0.005 to 0.5 mol of 1,4-diazabicayclo-(2,2,2)-octane are used as bicyclic organic amine per mol of the hydroxyl compound.

Abstract: The invention relates to phosphorylating agents containing at least one protected hydroxyl group and at least one leaving group. According to the invention, a methylsulphonylethyl group (Mse) is used as the hydroxyl protecting group. Typical examples of such phosphorylating agents are the compounds (MseO).sub.2 POL, (MseO)POLL', (MseO).sub.2 PL and (MseO)PLL', in which L and L' are leaving groups. The invention also relates to processes for preparing these phosphorylating agents and processes for the phosphorylation of organic hydroxyl or amine compounds, in particular nucleosides and (poly)nucleotides.

Abstract: Pyrazole derivatives, selective herbicidal compositions containing said derivatives and the use of said derivatives are provided. The pyrazole derivatives having selective herbicidal activity are represented by the formula I: ##STR1## wherein, X denotes a halogen, nitro or methanesulfonyl,Y denotes hydrogen, a lower alkyl or a halogen,Z denotes a halogen or methanesulfonyl, andR denotes hydrogen; an organic acid residue; a lower alkynyl; a lower alkyl or a lower alkenyl which may be substituted by a halogen, hydroxy, cyano or an alkoxycarbonyl; or a benzyl which may be substituted by a halogen, nitro or a lower alkyl.

Abstract: A compound of the formula: ##STR1## wherein Y is alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, a halogen atom, nitro or trifluoromethyl; and n is an integer of 1, 2 or 3; and when n is 2, Y.sub.n may be an alkylidenedioxy group; or a salt thereof. These compounds are useful in producing pyrazol-4-yl phosphates which posess insecticidal-acaricidal activity.

Abstract: A 4-pyrazolyl phosphorous acid ester of the following formula, ##STR1## (R is a lower alkyl group; Y is a phenyl group which may optionally be substituted by a halogen, halogens, a lower alkyl group or a halogen and a lower alkyl group.) which is produced by reacting corresponding 4-hydroxylpyrazole compound with a trialkyl phosphite. The ester gives 4-pyrazolyl phosphorothioate by the reaction with an alkylsulfenyl halide.

Abstract: Phosphoric or thiophosphoric esters of 5(3)-hydroxypyrazoles are disclosed having the formula: ##STR1## wherein: R=H; alkyl with 1-7 carbon atoms optionally substituted with halogens, CN, and carboalkoxy groups; phenyl optionally substituted; benzyl; alkenyl; or alkynyl;X=halogen; --SR; --OR; --N(R).sub.2 ; or ##STR2## where Y is equal to or different from each other, and =H; C.sub.1 -C.sub.3 alkyl; halogen; --SR; --OR; or --N(R).sub.2 ;Z=S; or O; andR.sup.1 and R.sup.2, equal to or different from each other, are: alkoxyls; alkyls; phenyls; or alkylthio- or alkylamino-groups.These are useful as insecticides, acaricides and nematodacides.

Abstract: 1-Pyrazolyl-phosphoric acid esters of the formula ##STR1## their preparation and use as crop protection agents, and their immediate precursors, i.e. halogenated 1-hydroxypyrazoles of the formula ##STR2## where R.sup.1 to R.sup.5, X and Y have the meanings given in the claims and description.

Abstract: These compounds are especially useful as intermediates to the corresponding thionophosphonic acid esters having insecticidal and acaricidal properties.

Abstract: The invention provides diiminourea, isothiourea and diisothiourea salts of N-Phosphonomethylglycine. The invention also provides phytotoxic compositions containing the same.

Abstract: Pyrazol-4-yl phosphates of the formula ##STR1## wherein R.sup.1 represents a lower alkyl group, R.sup.2 is a lower alkoxy group or a lower alkylthio group, R.sup.3 represents hydrogen or a lower alkoxycarbonyl group, X is oxygen or sulfur atom, Y represents a lower alkyl, a lower alkoxy or a lower alkylthio group, a halogen atom, nitro or trifluoromethyl, and n is zero or an integer of 1, 2 or 3, or Yn represents an alkylidenedioxy containing 1 to 3 carbon atoms, have marked insecticidal-acaricidal activity against household pests, plant pests, mites, etc. without substantial toxicity to warm-blooded animals and fishes.

Abstract: 1-Alkyl-5-substituted-4-chloropyrazole-3-yl-(thio)phosphates and (thio)phosphonates of the formula ##STR1## wherein R is lower alkyl; R.sup.1 is lower alkoxy; R.sup.2 is lower alkyl or lower alkoxy; X is chloro or the group --SR.sup.3 wherein R.sup.3 is lower alkyl; and Y is sulfur or oxygen are insecticidal, and are particularly effective against cabbage looper.

Abstract: Compounds of the formula: ##STR1## wherein R is lower alkyl; R.sup.1 is lower alkoxy or lower alkylthio; R.sup.2 is lower alkyl or lower alkoxy; R.sup.3 is lower alkyl; and Y is sulfur or oxygen, possess fungicidal and insecticidal activity.

Abstract: Phosphoric or thiophosphoric esters of 5(3)-hydroxypyrazoles are disclosed having the formula: ##STR1## wherein: R=H; alkyl with 1-7 carbon atoms optionally substituted with halogens, CN, and carboalkoxy groups; phenyl optionally substituted; benzyl; alkenyl; or alkynyl;X=halogen; --SR; --OR; --N(R).sub.2 ; or ##STR2## where Y is equal to or different from each other, and=H; C.sub.1 -C.sub.3 alkyl; halogen; --SR; --OR; or --N(R).sub.2 ;Z=S; or O; andR.sup.1 and R.sup.2, equal to or different from each other, are: alkoxyls; alkyls; phenyls; or alkylthio- or alkylamino-groups.These are useful as insecticides, acaricides and nematodacides.Also disclosed are 5(3)-hydroxypyrazoles having the formula: ##STR3## wherein: R=H; alkyl with 1-7 carbon atoms, optionally substituted with halogen atoms, CN, and carboalkoxy-groups; phenyl optionally substituted; benzyl; alkenyl; or alkynyl;X=halogen; --SR; --OR; --N(R).sub.2 ; or ##STR4## where Y is equal to or different from each other, and =H; C.sub.1 -C.sub.

Abstract: A multifunctional ashless additive is described having antiwear and antioxidant properties and high antirust power, and is prepared by reacting a O,O'-dialkylthiophosphoric acid with a compound chosen from substituted 2-oxazolines and substituted imidazolines.

Abstract: Pyrazolyl phosphates of the formula ##STR1## wherein R.sup.1 is alkyl, aralkyl, or phenyl which may optionally be substituted by halogen or lower alkyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen, halogen, nitro, lower alkyl or --COOR.sup.6 wherein R.sup.6 is lower alkyl; R.sup.4 is lower alkyl; R.sup.5 is lower alkylthio; and X is oxygen or sulfur, have marked insecticidal-acaricidal activity against household pests, plant pests and mites, without substantial toxicity to warm-blooded animals and fish.

Abstract: O-Ethyl-S-n-propyl-O-(1-substituted-pyrazol-4-yl)-(thiono)-thiolphosphoric acid esters of the formula ##STR1## wherein R is alkyl, cycloalkyl or phenyl, andX is oxygen or sulphur, which possess arthropodicidal and nematicidal properties.

Abstract: Organophosphorus esters, useful in increasing the resistance of keratinous materials to attack by keratin-eating insects, have the general formula: ##STR1## wherein: X and Y are independently O or S;R.sub.1 is an alkyl, alkoxy, alkylamino, dialkylamino or alkylmercapto radical having 1 to 6 carbon atoms;an amino or aryl radical;R.sub.2 is an alkyl radical having 1 to 6 carbon atoms;R.sub.3 is a radical of the general formula:-J-(K-L).sub.n (2)wherein:J is an aliphatic radical, or radical containing an aromatic or heterocyclic ring;K is one of the following radicals: ##STR2## linked to J through the oxygen atom in the case of (3), (5) or (6), and through the nitrogen atom in the case of (4), and in which the carbonyl oxygen atom of (3), (4) or (5), or one or both carbonyl oxygen atoms of (6) may be replaced by sulphur; R.sub.

Abstract: Phosphoric or thiophosphoric esters of 5(3)-hydroxypyrazoles are disclosed having the formula: ##STR1## wherein: R=H; alkyl with 1-7 carbon atoms optionally substituted with halogens, CN, and carboalkoxy groups; phenyl optionally substituted; benzyl; alkenyl; or alkynyl;X=halogen; --SR; --OR; --N(R).sub.2 ; or ##STR2## where Y is equal to or different from each other, and=H; C.sub.1 -C.sub.3 alkyl; halogen; --SR; --OR; or --N(R).sub.2 ;Z=S; or O; andR.sup.1 and R.sup.2, equal to or different from each other, are: alkoxyls; alkyls; phenyls; or alkylthio- or alkyl-amino-groups.These are useful as insecticides, acaricides and nematodacides.Also disclosed are 5(3)-hydroxypyrazoles having the formula: ##STR3## wherein: R=H; alkyl with 1-7 carbon atoms, optionally substituted with halogen atoms, CN, and carboalkoxy-groups; phenyl optionally substituted; benzyl; alkenyl; or alkynyl;X=halogen; --SR; --OR; --N(R).sub.2 ; or ##STR4## where Y is equal to or different from each other, and =H; C.sub.1 -C.sub.