Chalcogen Or Additional Nitrogen Attached Directly To Ring Carbon Of The Thiadiazole Ring By Nonionic Bonding Patents (Class 548/141)
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Patent number: 4831032Abstract: The present invention provides benzimidazoles of the general formula: ##STR1## wherein R.sub.1, X, A, and R.sub.2 are as defined in the specification. The present invention also provides processes for the preparation of these new benzimidazoles and pharmaceutical compositions containing them, as well as intermediates for the preparation thereof.The new benzimidazoles are useful to treat heart or circulatory diseases which respond to a lowering of blood pressure, a positive inotropic action and/or an improvement in microcirculation.Type: GrantFiled: July 3, 1986Date of Patent: May 16, 1989Assignee: Boehringer Mannheim GmbHInventors: Wolfgang von der Saal, Alfred Mertens, Herbert Berger, Bernd Muller-Beckmann, Klaus Strein
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Patent number: 4803211Abstract: This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH.sub.2 --S-- directly bound to the specific heterocyclic group. These heterocyclic compounds are useful as medicines, particularly as antagonists of SRS-A (slow reacting substance of anaphylaxis).Type: GrantFiled: July 14, 1986Date of Patent: February 7, 1989Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Toshiyasu Mase, Ryuji Tsuzuki, Hiromu Hara, Kiyoshi Murase, Kenichi Tomioka
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Patent number: 4782083Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: one of R.sub.1 and R.sub.2 is hydrogen or C.sub.1-4 alkyl and the other is C.sub.1-4 alkyl or R.sub.1 and R.sub.2 together are C.sub.2-5 -polymethylene;either R.sub.3 is hydrogen, hydroxy, C.sub.1-6 alkoxy or C.sub.1-7 acyloxy and R.sub.4 is hydrogen or R.sub.3 and R.sub.4 together are a bond;R.sub.5 is hydrogen C.sub.1-6 alkyl optionally substituted by halogen hydroxy, C.sub.1-6 alkoxy, C.sub.1-6 alkoxycarbonyl, carboxy or amino optionally substituted by one or two independent C.sub.1-6 alkyl groups, or C.sub.2-6 alkenyl, amino optionally substituted by a C.sub.1-6 alkyl or C.sub.1-6 alkenyl group or by a C.sub.1-6 alkanoyl group optionally substituted by up to three halo atoms, by a phenyl group optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen, or aryl or hetroaryl, either being optionally substituted by one or more groups or atoms selected from the class of C.sub.1-6 alkyl, C.sub.Type: GrantFiled: August 29, 1986Date of Patent: November 1, 1988Assignee: Beecham Group P.L.C.Inventors: Frederick Cassidy, Geoffrey Stemp, John M. Evans
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Patent number: 4742060Abstract: Novel insecticides of the formula ##STR1## in which n is 0 or 1,X is S, O, ##STR2## Y is N or ##STR3## Z is a 5- or 6-membered nitrogen-containing heterocyclic ring, and R to R.sup.9 variously represent hydrogen or specified organic radicals.Type: GrantFiled: January 21, 1986Date of Patent: May 3, 1988Assignee: Nihon Tokushu Noyaku Seizo K. K.Inventors: Kozo Shiokawa, Shinichi Tsuboi, Shinzo Kagabu, Koichi Moriya
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Patent number: 4738960Abstract: 1,3,4-Thiadiazole derivatives corresponding to the general formula I ##STR1## which constitute highly effective inhibitors for histamine-H.sub.2 receptors are described. These compounds in addition have a cytoprotective action.Type: GrantFiled: November 19, 1985Date of Patent: April 19, 1988Assignee: Ludwig Heumann & Co. GmbHInventors: Helmut Schickaneder, Rolf Herter, Kurt Wegner, Walter Schunack, Istvan Szelenyi, Stefan Postius, Kurt H. Ahrens
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Patent number: 4727081Abstract: 3,4-Diazole derivatives corresponding to the general formula I ##STR1## which exert a highly selective action on histamine-H.sub.2 receptors are described. Processes for the preparation of these compounds and pharmaceutical preparations containing these compounds are also described.Type: GrantFiled: November 7, 1985Date of Patent: February 23, 1988Assignee: Ludwig Heumann & Co. GmbHInventors: Kurt Wegner, Irene Kramer, Helmut Schickaneder, Walter Schunack, Istvan Szelenyi, Kurt H. Ahrens
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Patent number: 4696937Abstract: The invention relates to novel thiosulfonate derivatives of general formu a:R--S--SO.sub.2 --R.sub.1in which R represents a 1H-imidazol-2-yl, quinolin-2-yl, 5-amino-1,3,4-thiadizol-2-yl or 4,5-dihydro-thiazol-2-yl radical and R.sub.1 represents a lower alkyl, (hydroxy)lower alkyl, phenyl, (lower alkyl) phenyl, (hydroxy lower alkyl) phenyl, (lower alkanoyl) phenyl or quinolin-8-yl radical.The thiosulfonate derivatives in question exert an inhibitory action with respect to the malformation or destruction of red blood corpuscules due to a genetic modification of haemoglobin or to parasites and can, therefore, be used in the treatment of drepanocytosis, malaria and babebiosis.Type: GrantFiled: November 13, 1985Date of Patent: September 29, 1987Assignees: Sanofi, Institut National de la Sante et de la Recherche Medicale (Inserm)Inventors: Bernard Sebille, Yves Beuzard, Henri Demarne
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Patent number: 4695567Abstract: The present invention provided pyrrolobenzimidazoles or tautomer thereof, of the general formula: ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.3 -C.sub.7 cycloalkyl;R.sub.2 is hydrogen, cyano, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, or a carbonyl group substituted by hydroxyl, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkyoxy, amino, C.sub.1 -C.sub.6 alkylamino, C.sub.2 -C.sub.12 dialkylamino or hydrazino, orR.sub.2 and R.sub.1 together with the carbon to which they are attached form a C.sub.3 -C.sub.8 spirocycloalkyl ring, or R.sub.1 and R.sub.2 together form C.sub.3 -C.sub.7 alkylidene or C.sub.3 -C.sub.7 cycloalkylkidene,X is a valency bond, C.sub.1 -C.sub.Type: GrantFiled: January 17, 1986Date of Patent: September 22, 1987Assignee: Boehringer Mannheim GmbHInventors: Alfred Mertens, Jens-Peter Holck, Herbert Berger, Bernd Muller-Beckmann, Klaus Strein, Egon Roesch
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Patent number: 4678789Abstract: Compounds of the general formula: ##STR1## wherein Ar is naphthyl, biphenylyl, phenyl or substituted phenyl; n is 0, 1 or 2; and Het is a heterocyclic group which may optionally be substituted or fused to a phenyl, substituted phenyl or further heterocyclic ring; and their pharmaceutically acceptable salts are antifungal agents useful in combatting fungal infections in animals, including humans.Type: GrantFiled: March 28, 1983Date of Patent: July 7, 1987Assignee: Pfizer Inc.Inventors: Kenneth Richardson, Peter J. Whittle
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Patent number: 4673747Abstract: Substituted aminoalkylphenoxy derivatives represented by the general formula of: ##STR1## wherein the substituting group Z is either one of the following groups of: ##STR2## were prepared. These derivatives exert antagonism against Histamine H.sub.2 -receptors and hence are efficacious for the treatments of digestive ulcers.Type: GrantFiled: December 3, 1985Date of Patent: June 16, 1987Assignee: Ikeda Mohando Co., Ltd.Inventors: Fujio Nohara, Tomoaki Fujinawa
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Patent number: 4639523Abstract: Substituted aminoalkylphenoxy derivatives represented by the general formula of: ##STR1## wherein the substituting group Z is either one of the following groups of: ##STR2## These derivatives exert antagonism against Histamine H.sub.2 -receptors and hence are efficacious for the treatments of digestive ulcers.Type: GrantFiled: May 24, 1985Date of Patent: January 27, 1987Assignee: Ikeda Mohando Co., Ltd.Inventors: Fujio Nohara, Tomoaki Fujinawa
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Patent number: 4639526Abstract: 2-(alkyl, alkenyl and alkylmercapto)-5-[N-(alkanoyl, chloroalkanoyl, alkoxycarbonyl, phenoxy carbonyl, N'-[alkyl and alkenyl]-aminocarbonyl and N'-alkyl-N'-[alkyl and alkenyl]-aminocarbonyl)-amino]-1,3,4-thiadiazoles, i.e. 2-(alkyl, alkenyl and alkylmercapto)-5-[N-(alkanoylamino, chloroalkanoylamino, alkoxycarbonylamino, phenoxycarbonylamino, N'-[alkyl and alkenyl]-ureido and N'-alkyl-N'-[alkyl and alkenyl]-ureido)]-1,3,4-thiadiazoles, which possess herbicidal properties, and which may be produced by conventional methods.Type: GrantFiled: August 29, 1968Date of Patent: January 27, 1987Assignee: Bayer AktiengesellschaftInventors: Carl Metzger, Ludwig Eue, Helmuth Hack
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Patent number: 4632927Abstract: A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including cytoprotective, H.sub.2 -antagonist, anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions are disclosed.Type: GrantFiled: March 20, 1984Date of Patent: December 30, 1986Assignee: William H. Rorer, Inc.Inventors: Henry F. Campbell, Donald E. Kuhla, William L. Studt, Stuart A. Dodson
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Patent number: 4604132Abstract: The invention concerns novel compounds of the formula I ##STR1## wherein: A, B and D are selected from CH and N;E is selected from oxygen and sulfur;X are selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, alkanoyloxy, benzyloxy, substituted benzyloxy, phenyl, substituted phenyl, amino, substituted amino, and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof;R.sup.1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl;R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl;R.sup.Type: GrantFiled: April 27, 1984Date of Patent: August 5, 1986Assignee: ICI Australia LimitedInventors: Richard J. Conway, Keith G. Watson, Graeme J. Farquharson
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1,3,4-thiadiazole derivatives, process for the production thereof and use thereof as antiulcer agent
Patent number: 4587254Abstract: New 1,3,4-thiadiazole derivatives of the general formula (I): ##STR1## wherein R.sub.1 represents a group of the formula: ##STR2## and R.sub.2 represents an amino, lower alkylamino, cyclohexylamino, benzoylamino, mercapto or lower alkylthio group, a process for the production of them and the use of the derivatives as antiulcer agents.Type: GrantFiled: July 19, 1984Date of Patent: May 6, 1986Assignee: Wakamoto Pharmaceutical Co., Ltd.Inventors: Hatsunori Toyofuku, Yoshihiro Tsuriya, Toshio Kuroda, Hitoshi Aoki, Hiroshi Nagasawa -
Patent number: 4584114Abstract: Mercaptothiadiazole adducts of unsaturated esters such as jojoba oil or pentaerythritol tetraoleate are highly effective multifunctional friction reducing and copper strip passivating additives for various lubricants.Type: GrantFiled: December 20, 1982Date of Patent: April 22, 1986Assignee: Mobil Oil CorporationInventors: Robert M. Gemmill, Andrew G. Horodysky, Phillip S. Landis
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Patent number: 4562260Abstract: An improved process for the production of certain 1,3,4-thiadiazole-5-sulfonamides, specifically the precursor to 5-[[(dimethylamino)-carbonyl]methylamino]-N,N-dimethyl-1,3,4-thiadiazole-2 -sulfonamide.Type: GrantFiled: July 3, 1984Date of Patent: December 31, 1985Assignee: Union Carbide CorporationInventors: Roger L. McDaniel, Jr., Jeffrey W. Portzer, Edward J. Zaiko
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Patent number: 4539408Abstract: Quaternary sulfoalkyl or sulfoalkenyl salts of tertiary amine bases are prepared by reacting the tertiary amine bases at elevated temperatures with a hydroxy alkane sulfonic acid or a hydroxyalkene sulphonic acid.Type: GrantFiled: April 28, 1978Date of Patent: September 3, 1985Assignee: Agfa-Gevaert AktiengesellschaftInventors: Helmut Kampfer, Marie Hase, Max Glass
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Patent number: 4500715Abstract: 1,3,4-Thiazole derivatives of the formula ##STR1## wherein R.sub.26 ' denotes a C.sub.1 -C.sub.8 -alkyl radical which is optionally substituted by hydroxyl, halogen, cyano, C.sub.1 -C.sub.4 -alkoxy, carboxyl, aminocarbonyl or C.sub.1 -C.sub.4 -alkoxycarbonyl, a C.sub.2 -C.sub.4 -alkenyl radical, a cyclohexyl radical which is optionally substituted by C.sub.1 -C.sub.4 -alkyl, a phenyl, benzyl or phenylethyl radical which is optionally substituted by halogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, a C.sub.1 -C.sub.2 -alkylcarbonyl, C.sub.1 -C.sub.4 -alkoxycarbonyl, mono- or di-C.sub.1 -C.sub.4 -alkylaminocarbonyl, aminocarbonyl, mono- or di-C.sub.1 -C.sub.4 -alkylaminosulphonyl, 2-thienyl, 2-furyl, 2-tetrahydrofuryl, amino, C.sub.1 -C.sub.4 -alkylamino or di-(C.sub.1 -C.sub.4 -alkyl)-amino radical or a phenylamino or benzylamino radical which is optionally substituted by C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy and R.sub.27 ' denotes a C.sub.1 -C.sub.Type: GrantFiled: January 26, 1981Date of Patent: February 19, 1985Assignee: Bayer AktiengesellschaftInventor: Hauke Furstenwerth
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Patent number: 4492793Abstract: 2-Amino-5-mercapto-1,3,4-thiadiazoles can be produced in very high yields from thiosemicarbazides and carbon disulfide in aqueous phase by working in the presence of the corresponding ammonium salt of bis-2,5-mercapto-1,3,4-thiadiazole at a temperature above 40.degree. C. Preferably the process is carried out in the presence of the mother liquor from a previous reaction.Type: GrantFiled: August 13, 1982Date of Patent: January 8, 1985Assignee: Degussa AktiengesellschaftInventor: Herbert Klenk
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Patent number: 4456551Abstract: Disclosed are novel azo dyes from 2-amino-5-alkylthio-1,3,4-thiadiazoles and N-acyloxyalkyl-m-acylamidoanilines. These dyes are useful for dyeing synthetic hydrophobic fibers and particularly polyester. The dyes have the general formula: ##STR1## wherein R is alkyl; X is hydrogen, or alkyl; R.sub.1 is hydrogen, alkyl, aralkyl or ##STR2## R.sub.2 is alkyl, aryl, aralkyl, cycloalkyl, alkylamino, or arylamino; and Ac is formyl or alkanoyl; and wherein R and the alkyl, alkylene, aryl and cycloalkyl moieties of R.sub.2 and the alkanoyl moiety of Ac may be substituted with a large variety of groups such as --OH, OOC-alkyl, --COO--alkyl, succinimido, phthalimido, alkoxy, carbamoyl and the like.Type: GrantFiled: July 11, 1983Date of Patent: June 26, 1984Assignee: Eastman Kodak CompanyInventors: Max A. Weaver, Clarence A. Coates, Jr.
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Patent number: 4448968Abstract: A process for preparing 1,3,4-thiadiazolone compounds of the formula ##STR1## comprising reacting a 2-alkoxy-1,3,4-thiadiazole of the formula ##STR2## with hydrogen chloride in non-aqueous organic solvent under non-aqueous conditions at a temperature of from 0.degree. to 100.degree. C.Type: GrantFiled: February 23, 1982Date of Patent: May 15, 1984Assignee: Ciba-Geigy CorporationInventor: Haukur Kristinsson
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Patent number: 4428953Abstract: Novel pleuromutilin derivatives of formula I, ##STR1## in which R.sub.1 is ethyl or vinyl,m is 0 or 1, andR.sub.2 is a heterocyclic radical, in which a 5- or 6-membered, unsaturated or saturated heterocyclic ring containing one or more hetero atoms selected from oxygen, sulphur and nitrogen, is attached to the --S(CH.sub.2).sub.m --group,provided that when m is 0, R.sub.2 is other than pyridyl,their production and use as antimicrobial agents are described.Type: GrantFiled: March 8, 1982Date of Patent: January 31, 1984Assignee: Sandoz, Ltd.Inventors: Heinz Berner, Friederike Turnowsky, Georg Laber, Johannes Hildebrandt
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Patent number: 4412079Abstract: Novel thiadiazole compounds are disclosed which contain in the 5 position, C-linked moieties which are either acyclic hydrocarbon radicals or halogenated acyclic hydrocarbon radicals (in which case each halogen is independently selected from F, Cl and Br). These novel compounds also contain an exocyclic nitrogen in the 2 position, and some of them contain the exocyclic substituent: ##STR1## wherein R.sub.3 is a lower acyclic hydrocarbon radical and R.sub.4 is either H or a lower acyclic hydrocarbon radical. Synthesis of these compounds is disclosed, including synthesis of those which exhibit isomerism and/or tautomerism.Various of these compounds have various agricultural utilities (e.g. as herbicides, insecticides, acaricides and fungicides), each of them having at least one such biological utility. Methods of using these compounds in phytotoxic fungicidal, acaricidal and insecticidal applications are disclosed.Type: GrantFiled: September 20, 1982Date of Patent: October 25, 1983Assignee: Air Products and Chemicals, Inc.Inventors: Tony Cebalo, Robert A. Walde
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Patent number: 4401817Abstract: Certain carbonyl-substituted-1-sulfonylbenzimidazole compounds are useful as antiviral agents.Type: GrantFiled: April 21, 1982Date of Patent: August 30, 1983Assignee: Eli Lilly and CompanyInventors: Charles J. Paget, James W. Chamberlin, James H. Wikel
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Patent number: 4395419Abstract: Amidinoformic acids and amidinosulphinic acids which are histamine H.sub.2 -antagonists. A specific compound of this invention is N-[2-(3-(1,2,5)-thiadiazolylmethylthio)ethyl]amidinoformic acid.Type: GrantFiled: August 10, 1981Date of Patent: July 26, 1983Assignee: Smith Kline & French Laboratories LimitedInventors: Graham J. Durant, Charon R. Ganellin, Rodney C. Young
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Patent number: 4389403Abstract: 1-Aroyl-2-phenylamino-2-imidazolines of the general formula ##STR1## where R.sup.1 and R.sup.2 are identical or different and each is chlorine, bromine, fluorine, methyl, ethyl, methoxy, trifluoromethyl or cyano,R.sup.3 has the meanings given for R.sup.1 and R.sup.2 or is hydrogen andAr is an unsubstituted or substituted monocyclic or bicyclic heteroaromatic radical containing 1, 2 or 3 nitrogen and/or oxygen and/or sulfur atoms, their salts with physiologically tolerated acids, their preparation, and drugs containing these compounds.The compounds have, inter alia, a blood pressure-reducing action.Type: GrantFiled: March 3, 1981Date of Patent: June 21, 1983Assignee: BASF AktiengesellschaftInventors: Hans-Joachim May, Dieter Lenke, Josef Gries, Hans-Juergen Teschendorf, Wolfgang Worstmann
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Patent number: 4382869Abstract: Dimercaptothiadiazole adducts of hydroxyl-containing unsaturated compounds and their borated analogues provide effective multifunctional friction reducing and corrosion inhibiting properties to various lubricating fluids when incorporated therein.Type: GrantFiled: June 18, 1981Date of Patent: May 10, 1983Assignee: Mobil Oil CorporationInventors: Andrew G. Horodysky, Phillip S. Landis, Robert M. Gemmill, Jr.
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Patent number: 4374993Abstract: Disclosed is a novel process for the preparation of the sulfate salt of 2-amino-5-alkylthio-1,3,4-thiadiazoles, which comprises reacting 2,5-dithiobiurea with a dialkylsulfate. Derivatives of compounds produced by this novel process are useful as chemical synthetic intermediates in the preparation of organic dyes and pharmaceuticals.Type: GrantFiled: June 8, 1981Date of Patent: February 22, 1983Assignee: Eastman Kodak CompanyInventor: Kim S. Chamberlin
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Patent number: 4372963Abstract: Bisamidines carrying one unsaturated nitrogen heterocyclo-containing substituent, representative of which i; 1-[N'-(2-(5-methyl-4-imidazolyl)methylthio)ethyl)guanidino]-8-[N'-methylgu anidino]octane, are histamine H.sub.2 -antagonists.Type: GrantFiled: March 27, 1981Date of Patent: February 8, 1983Assignee: Smith Kline & French Laboratories LimitedInventors: Graham J. Durant, Peter D. Miles
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Patent number: 4338329Abstract: Certain carbonyl-substituted-1-sulfonylbenzimidazole compounds are useful as antiviral agents.Type: GrantFiled: April 20, 1981Date of Patent: July 6, 1982Assignee: Eli Lilly and CompanyInventors: Charles J. Paget, James W., both of Chamberlin, James H. Wikel
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Patent number: 4338328Abstract: The compounds are sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines which are useful to produce inhibition of histamine H-2 receptors.Type: GrantFiled: October 16, 1980Date of Patent: July 6, 1982Assignee: SmithKline & French Laboratories LimitedInventor: George R. White
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Patent number: 4331668Abstract: 3-Nitro-2-substituted aminopyrroles are histamine H.sub.2 -receptor antagonists. The 2- position substituent is a fully-unsaturated heterocyclyl alkyl group preferably with alkyl group interrupted by sulfur or oxygen. The 4- and 5- positions of the pyrrole ring can also be substituted.Type: GrantFiled: June 16, 1980Date of Patent: May 25, 1982Assignee: Smith Kline & French Laboratories LimitedInventors: Michael L. Roantree, Rodney C. Young
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Patent number: 4329475Abstract: Disclosed are selected poly(oxyalkylated) 1,3,4-thiadiazoles of the formula: ##STR1## wherein each R is individually selected from hydrogen and methyl; and the sum of y and z is from 2 to about 30. These compounds are shown to be effective corrosion inhibitors in corrosive liquids such as acid metal-treating baths.Type: GrantFiled: November 10, 1980Date of Patent: May 11, 1982Assignee: Olin CorporationInventor: Eugene F. Rothgery
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Patent number: 4316021Abstract: Certain 1-sulfonyl-2,5(6)-substituted-benzimidazole compounds are useful as antiviral agents.Type: GrantFiled: September 2, 1980Date of Patent: February 16, 1982Assignee: Eli Lilly and CompanyInventors: Charles J. Paget, James H. Wikel
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Patent number: 4301019Abstract: Mercaptothiadiazole is reacted with hydroxyl-containing unsaturated esters, or their borated derivatives, to yield a product that is useful as a friction reducing additive in lubricants.Type: GrantFiled: October 29, 1980Date of Patent: November 17, 1981Assignee: Mobil Oil CorporationInventors: Andrew G. Horodysky, Phillip S. Landis
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Patent number: 4290798Abstract: This invention relates to a novel substituted thiadiazole, identified as 1-[5-(2-chloro-1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]-1,3-dimethylurea, to its use in a novel method for the control of unwanted vegetation, and to a novel herbicidal composition employing the substituted thiadiazole as the herbicidally-active ingredient.Type: GrantFiled: November 29, 1978Date of Patent: September 22, 1981Assignee: Air Products and Chemicals, Inc.Inventors: Tony Cebalo, Robert A. Walde
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Patent number: 4284640Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]e thylene.Type: GrantFiled: February 4, 1980Date of Patent: August 18, 1981Assignee: Smith Kline & French Laboratories LimitedInventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin, Hunter D. Prain
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Patent number: 4265898Abstract: The present invention relates to certain new imidazo [2,1-b]-[1,3,4]-thiadiazole compounds, to the provision of pharmaceutical compositions containing said compounds and to the use of said compounds and compositions as antithrombotic agents and thrombolytic agents.Type: GrantFiled: May 10, 1979Date of Patent: May 5, 1981Assignee: Bayer AktiengesellschaftInventors: Harald Horstmann, Karl-August Meng, deceased, by Matthias Meng, legal representative, Friedel Seuter, Eike Moller
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Patent number: 4252962Abstract: Disclosed is a process for producing 2-amino or 2-(lower alkyl or phenyl)amino-5-mercapto-1,3,4-thiadiazole compounds by reacting the corresponding thiosemicarbazide with an alkali metal lower alkyl xanthate salt.Type: GrantFiled: March 24, 1980Date of Patent: February 24, 1981Assignee: Olin CorporationInventor: Eugene F. Rothgery
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Patent number: 4251664Abstract: Certain sulfonamidothiadiazoles, metal complexes thereof and solutions of said compounds in essentially water-immiscible, liquid hydrocarbon solvents are disclosed. The sulfonamidothiadiazoles have the general structural formula: ##STR1## wherein R and A are as defined in the specification and claims hereof. Particular metal values are recovered from their aqueous solutions by using sulfonamidothiadiazoles dissolved in essentially water-immiscible, liquid hydrocarbon solvents. The extraction process involves contacting the metal value containing aqueous solution with the solution of the sulfonamidothiadiazole in essentially water-immiscible, liquid hydrocarbon solvent and stripping the metal from the loaded organic phase.Type: GrantFiled: May 24, 1978Date of Patent: February 17, 1981Assignee: Henkel CorporationInventor: Ernest B. Spitzner
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Patent number: 4230865Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.Type: GrantFiled: September 8, 1978Date of Patent: October 28, 1980Assignee: Smith Kline & French Laboratories LimitedInventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin
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Patent number: 4228291Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.Type: GrantFiled: October 4, 1978Date of Patent: October 14, 1980Assignee: Smith Kline & French Laboratories LimitedInventors: Graham J. Durant, John C. Emmett, Charon R. Genellin
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Patent number: 4201713Abstract: The subject of the invention are dyestuffs of the formula ##STR1## wherein R is hydrogen or a hydrocarbon radicalQ is arylX is .dbd.C(W) -- or .dbd.N--,W is a nitrile ester or amide groups andA represents the remaining members of a heterocyclic radical.The dyestuffs are preferably suitable for dyeing polyester fibres which are dyed in orange, red, violet or bluish shades with good fastness to light.Type: GrantFiled: February 25, 1977Date of Patent: May 6, 1980Assignee: Bayer AktiengesellschaftInventor: Horst Harnisch
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Patent number: 4196125Abstract: Certain 1-sulfonyl-2,5(6)-substituted-benzimidazole compounds are useful as antiviral agents.Type: GrantFiled: March 16, 1978Date of Patent: April 1, 1980Assignee: Eli Lilly and CompanyInventors: Charles J. Paget, James H. Wikel