Patent number: 7235669
Abstract: The invention concerns compounds which can be obtained by fermenting DSM 6773, especially epothilones A1, A2, A8, A9, B10, C1, C2, C3, C4, C5, C6, C7, C8, C9, D1, D2, D5, G1, G2, H1, H2, I1, I2, I3, I4, I5, I6 and K and trans-epothilones C1 and C2.
Type:
Grant
Filed:
February 15, 2006
Date of Patent:
June 26, 2007
Assignee:
Helmholtz-Zentrum fur Infektionsforschung, GmbH
Inventors:
Gerhard Hoefle, Hans Reichenbach, Klaus Gerth, Ingo Hardt, Florenz Sasse, Heinrich Steinmetz
Patent number: 6699896
Abstract: This invention provides compounds having the structure
wherein
A is OR5, or
R1 is alkyl, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, pyridyl,
R2 is H, alkyl, or aryl; R3 and R4 are halo, H, alkyl, aryl, trifluoromethyl, alkoxyaryl, nitro, amino, carboalkoxy, carbamide, carbamate, urea, alkylsulfonamide, —NR7(CH2)mCO2H, arylsulfonamide, cycloalkyl, or a heterocycle; R5 is H, alkyl, —CH(R8)R9, —CH2(CH2)nCO2R10, —C(CH3)2CO2R10, —CH(R8)(CH2)nCO2R10, —CH(R8)C6H4CO2R10, or —CH2-tetrazole; R6 is H, alkyl, halo, alkoxy, trifluoroalkyl or trifluoroalkoxy; R7 is H or alkyl; R8 is H, alkyl, aryl, arylalkyl, cycloalkyl, phthalic acid,
R9 is CO2R12, CONHR12, tetrazole, or PO3R12; R10 is H, alkyl, aryl, or aralkyl;
R11 is alkyl; R12 is H, alkyl, aryl, or aralkyl; X is O, or S; Y is O, N, or S; Z is C, or N;
Q is O, N, or S; m=1-3; n=1-6, or a pharmaceutically acceptable salt thereof, which
Type:
Grant
Filed:
May 10, 1999
Date of Patent:
March 2, 2004
Assignee:
Wyeth
Inventor:
Michael S. Malamas