At Least Three Ring Hetero Atoms In The Polycyclo Ring System Patents (Class 548/218)
-
Patent number: 7262212Abstract: The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R2 represents a group —OR3 or the like, and R3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R1 and —(CH2)nR2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.Type: GrantFiled: October 10, 2003Date of Patent: August 28, 2007Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Hidetsugu Tsubouchi, Hirofumi Sasaki, Hideaki Kuroda, Motohiro Itotani, Takeshi Hasegawa, Yoshikazu Haraguchi, Takeshi Kuroda, Takayuki Matsuzaki, Kuninori Tai, Makoto Komatsu, Makoto Matsumoto, Hiroyuki Hashizume, Tatsuo Tomishige, Yuji Seike, Masanori Kawasaki, Takumi Sumida, Shin Miyamura
-
Patent number: 7253154Abstract: The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which may have a substituent or the like; R2 is halogen, nitro, cyano, carboxyl, or the like; R3 is hydrogen, halogen, hydroxyl, amino, carboxyl, or the like; X is NR11, oxygen, or sulfur, in which R11 is hydrogen, or an alkyl group having 1-8 carbon atom which may have a substituent; and each of Y and Z is CR12 or nitrogen, in which R12 has the same meaning as R3 above, and a xanthine oxidase inhibitor containing the compound as an active ingredient.Type: GrantFiled: November 14, 2002Date of Patent: August 7, 2007Assignee: Nippon Chemiphar Co., Ltd.Inventors: Shinichi Yoshida, Atsushi Tendo, Kunio Kobayashi, Nobutaka Mochiduki, Tomio Yamakawa, Yoriko Shinohara
-
Patent number: 7252892Abstract: An organic electroluminescent (EL) device which contains a novel coumarin derivative composed of a coumarin ring, a naphthalene ring with one or more hydrocarbon groups, and a five-membered hetero ring condensed with the naphthalene ring so as to give an electronic resonance through the coumarin and naphthalene rings. The coumarin derivative emits a visible luminescence with a satisfactory color purity, which consistently continues over a long period of time even at an elevated temperature when used in such an organic device.Type: GrantFiled: April 23, 2002Date of Patent: August 7, 2007Assignees: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Kabushiki Kaisha Toyota JidoshokkiInventors: Makoto Satsuki, Natsuko Ishida, Sadaharu Suga, Hisayoshi Fujikawa, Yasunori Taga
-
Patent number: 7232815Abstract: The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-? (TNF-?) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.Type: GrantFiled: April 9, 2003Date of Patent: June 19, 2007Assignee: GlaxoSmithKlineInventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Iva Benko
-
Patent number: 7230112Abstract: Described in this invention is a catalytic process for making amide acetals from nitrites and diethanolamines. Amide acetals can be further crosslinked by hydrolyzing the amide acetal groups, and subsequently reacting the hydroxyl groups and/or the amine functions that are formed, to crosslink the composition.Type: GrantFiled: October 7, 2004Date of Patent: June 12, 2007Assignee: E. I. duPont de Nemours and CompanyInventors: Douglas J. Adelman, Neville Everton Drysdale, Christian Peter Lenges, Mark A. Scialdone, Leen Tanghe, Jozef Theresia Huybrechts, Laura Ann Lewin, Robert John Barsotti
-
Patent number: 7173051Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.Type: GrantFiled: June 10, 2004Date of Patent: February 6, 2007Assignee: IRM, LLCInventors: Hong Liu, David Tully, Phillip Alper, Robert Epple, Arnab Chatterjee, Michael Roberts
-
Patent number: 7161010Abstract: Disclosed is a compound represented by the following formula (I): wherein Z1 represents an atomic group necessary to form a 5- or 6-membered nitrogen-containing heterocyclic ring; Z2 represents an atomic group necessary to form a 5- or 6-membered heterocyclic ring, Z2 may further be substituted, or may be condensed with a hetero ring of a benzene ring; R1 represents a hydrogen atom, a halogen atom, a mercapto group, an alkyl group, an alkenyl group, an aryl group, an alkylthio group, an alkenylthio group, or an arylthio group; L1 and L2 each represents a methine group; pi represents 0 or 1; V1 represents a substituent; and n represents 0, 1 or 2, and when n represents 2, a plurality of V1 may be the same or different.Type: GrantFiled: August 1, 2003Date of Patent: January 9, 2007Assignee: Fuji Photo Film Co., Ltd.Inventors: Katsumi Kobayashi, Takashi Katoh, Junji Nishigaki
-
Patent number: 7112582Abstract: The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X is S.Type: GrantFiled: May 1, 2003Date of Patent: September 26, 2006Assignee: WyethInventors: Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Itsuki Yamamura, Tsuyoshi Takasaki, Atul Agarwal, Osvaldo dos Santos, Fuk-Wah Sum, Yang-I Lin
-
Patent number: 7094516Abstract: An optical recording medium having an organic dye layer as a recording layer on a substrate, wherein at least one benzobisazole-based compound represented by a general formula (1) is contained in the recording layer: (wherein substituents X and Y each independently represent an aryl group or a heteroaryl group, rings A and B each independently represent an oxazole ring or a thiazole ring, and Q1 and Q2 each independently represent a hydrogen atom, a halogen atom or an alkyl group, with a proviso that, aryl group(s) or heteroaryl group(s) represented by the substituents X and Y each independently may be substituted by a halogen atom, a hydroxyl group, a cyano group, an amino group or a substituted or unsubstituted alkyl, aralkyl, aryl, alkenyl, alkoxy, aralkyloxy, aryloxy, alkenyloxy, alkylthio, aralkylthio, arylthio, alkenylthio, mono-substituted amino, di-substituted amino, acyl, alkoxycarbonyl, aralkyloxycarbonyl, aryloxycarbonyl, alkenyloxycarbonyl, mono-substituted aminocarbonyl, di-substituted aminocType: GrantFiled: January 5, 2001Date of Patent: August 22, 2006Assignee: Mitsui Chemicals, Inc.Inventors: Akira Ogiso, Shinobu Inoue, Hisashi Tsukahara, Taizo Nishimoto, Tsutami Misawa
-
Patent number: 7091196Abstract: The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents, and/or prokinetic (gastrointestinal modulatory) agents, having the formula: or pharmaceutically acceptable salts, esters, or prodrugs thereof.Type: GrantFiled: September 25, 2003Date of Patent: August 15, 2006Assignee: Rib-X Pharmaceuticals, Inc.Inventors: Deping Wang, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Timothy S. McConnell, Joseph A. Ippolito, John N. Abelson, Dane M. Springer, Joseph M. Salvino, Rongliang Lou, Joel A. Goldberg, Jay J. Farmer, Erin M. Duffy, Ashoke Bhattacharjee
-
Patent number: 6911445Abstract: Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.Type: GrantFiled: September 10, 2003Date of Patent: June 28, 2005Assignee: WyethInventors: Deborah Ann Evrard, Gary Paul Stack, Uresh Shantilal Shah
-
Patent number: 6891043Abstract: Potent inhibitors of fatty acid amide hydrolase (FAAH) are constructed having K1's below 200 pM and activities 102-103 times more potent than the corresponding trifluoromethyl ketones. The potent inhibitors combine several features, viz.: 1.) an ?-keto heterocylic head group; 2.) a hydrocarbon linkage unit employing an optimal C12-C8 chain length; and 3.) a phenyl or other ?-unsaturation corresponding to the arachidonyl ?8,9/?11,12 and/or oleyl ?9,10 positions. A preferred ?-keto heterocylic head group is ?-keto N4 oxazolopyridine, with incorporation of a second weakly basic nitrogen. Fatty acid amide hydrolase is an enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid) and anandamide (an endogenous ligand for cannabinoid receptors).Type: GrantFiled: October 8, 2002Date of Patent: May 10, 2005Assignee: The Scripps Research InstituteInventor: Dale L. Boger
-
Patent number: 6888003Abstract: A process for preparing 7-(pyrazol-3-yl)benzoxazoles of the formula I in which the variables R1-R6 are as defined in claim 1, which process is characterized in that a 2-halo-3-(pyrazol-3-yl)anilide of the formula II, in which X is bromine or iodine is reacted with a base in the presence of a transition metal compound of subgroup VIIa, VIIIa or Ib of the Periodic Table of the Elements, is disclosed.Type: GrantFiled: March 15, 2001Date of Patent: May 3, 2005Assignee: BASF AktiengesellschaftInventors: Cyrill Zagar, Robert Reinhard, Michael Puhl, Thorsten Volk, Norbert Götz, Gerhard Hamprecht, Olaf Menke, Ingo Sagasser
-
Patent number: 6858607Abstract: The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: or pharmaceutically acceptable salts or prodrugs thereof, wherein: wherein A, R1, R2, R5, X, Y, and Z, are defined herein and B is a fused thiazole, oxazole, 2-imino-imidazole, 2,1,3-thiadiazo-2-one, thiazol-2-one, oxazol-2-one, imidazol-2-thione, thiazol-2-thione, oxazol-2-thione, imidazoline, oxazoline, thiazoline, triazole, oxazine, oxazine-2,3-dione, or piperazine ring. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.Type: GrantFiled: May 16, 2002Date of Patent: February 22, 2005Assignee: Cytovia, Inc.Inventors: Sui Xiong Cai, Lifen Xu, Richard Storer, Giorgio Attardo
-
Publication number: 20040242874Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification 1Type: ApplicationFiled: May 12, 2004Publication date: December 2, 2004Applicant: Wyeth Holdings CorporationInventors: Michael William Winkley, Anita Wai-Yin Chan, Ivo L. Jirkovsky, Kenneth Alfred Martin Kremer, Joseph Zeldis, Antonia Aristotelevna Nikitenko, Henry Lee Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam M. Venkatesan
-
Patent number: 6815448Abstract: Compounds of the formula are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia. The compounds of the invention are also useful for the treatment of disorders such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior.Type: GrantFiled: April 25, 2002Date of Patent: November 9, 2004Assignee: WyethInventors: Gary P. Stack, Megan Tran
-
Patent number: 6800637Abstract: Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.Type: GrantFiled: September 10, 2003Date of Patent: October 5, 2004Assignee: WyethInventors: Gary Paul Stack, Michael Byron Webb, Deborah Ann Evrard, Dahul Zhou
-
Patent number: 6800648Abstract: Compounds of the formula useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced pychoses and dyskinesias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addiction to ethanol, nicotine or cocaine and related illnesses.Type: GrantFiled: April 25, 2002Date of Patent: October 5, 2004Assignee: WyethInventors: Megan Tran, Gary P. Stack
-
Publication number: 20040138222Abstract: Compounds of the formula: 1Type: ApplicationFiled: September 10, 2003Publication date: July 15, 2004Inventors: Gary Paul Stack, Michael Byron Webb, Deborah Ann Evrard, Dahui Zhou
-
Publication number: 20040106597Abstract: Novel fused indazoles and indoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.Type: ApplicationFiled: November 25, 2003Publication date: June 3, 2004Inventors: Jesse A. May, Anura P. Dantanarayana
-
Patent number: 6723731Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as defined in the specification. These compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).Type: GrantFiled: April 13, 2001Date of Patent: April 20, 2004Assignees: Novo Nordisk A/S, Dr. Reddy's Research FoundationInventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
-
Patent number: 6706879Abstract: The invention relates to fluorescent dyes. More particularly, the invention relates to fluorescent cyanine dyes, and especially to water soluble fluorescent cyanine dyes that contain additional sites for attachment to biomolecules. The invention provides a group of novel, water soluble fluorescent cyanine dyes that have distinct fluorescence characteristics that permit their use in any assay or method suited to water soluble fluorescent dyes, and especially to assays requiring a plurality of distinguishable fluorescent markers. The invention further relates to nucleotides, nucleosides, polynucleotides and polypeptides labeled with novel fluorescent cyanine dyes according to the invention, and methods of using them.Type: GrantFiled: February 28, 2002Date of Patent: March 16, 2004Assignee: StratageneInventors: Jack Anderson, Jeffrey Carl Braman
-
Patent number: 6696441Abstract: The present invention provides compounds that act to suppress p53 activity in mammalian cells, and a method to effectively suppress p53 activity in the cells of a mammal subject to a stress or pathology that is ameliorated by such suppression.Type: GrantFiled: August 11, 2000Date of Patent: February 24, 2004Assignee: The Regents of the University of CaliforniaInventors: Howard B. Cottam, Lorenzo M. Leoni, Dennis A. Carson
-
Patent number: 6667405Abstract: Disclosed is a compound represented by the following formula (I): wherein Z1 represents an atomic group necessary to form a 5- or 6-membered nitrogen-containing heterocyclic ring; Z2 represents an atomic group necessary to form a 5- or 6-membered heterocyclic ring, Z2 may further be substituted, or may be condensed with a hetero ring or a benzene ring; R1 represents a hydrogen atom, a halogen atom, a mercapto group, an alkyl group, an alkenyl group, an aryl group, an alkylthio group, an alkenylthio group, or an arylthio group; L1 and L2 each represents a methine group; p1 represents 0 or 1; V1 represents a substituent; and n represents 0, 1 or 2, and when n represents 2, a plurality of V1 may be the same or different.Type: GrantFiled: November 1, 2001Date of Patent: December 23, 2003Assignee: Fuji Photo Film Co., Ltd.Inventors: Katsumi Kobayashi, Takashi Katoh, Junji Nishigaki
-
Publication number: 20030195361Abstract: This invention relates to compounds of Formula I 1Type: ApplicationFiled: February 14, 2003Publication date: October 16, 2003Applicant: Pfizer Inc.Inventor: Daisy Joe Du Bois
-
Patent number: 6613913Abstract: Compounds of the formula: useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.Type: GrantFiled: January 10, 2003Date of Patent: September 2, 2003Assignee: WyethInventors: Megan Tran, Gary P. Stack
-
Publication number: 20030158243Abstract: Novel carbohydrate-based compounds with an attached ring system that have antimicrobial or cytostatic activity. The compounds are administered to humans and animals for the treatment or amelioration of bacterial, fungal, viral or protozoal infections or tumors.Type: ApplicationFiled: October 15, 2001Publication date: August 21, 2003Inventors: Benedikt Sas, Johan Van der Eycken, Johan Van hemel, Petra Blom, Jan Vandenkerckhove, Bart Ruttens
-
Publication number: 20030143699Abstract: The present invention provides a process for preparation of optically active azabicyclo heptanone derivatives using lactamases that will react with racemic −lactam of formula (I) to give a single enantiomer of lactam (III) and the corresponding ring opened compound of formula (IV) in an enantiomerically pure form.Type: ApplicationFiled: December 27, 2001Publication date: July 31, 2003Inventors: Rohini Ramesh Joshi, Asmita Ashutosh Prabhune, Ramesh Anna Joshi, Mukund Keshav Gurjar
-
Patent number: 6586452Abstract: The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.Type: GrantFiled: July 9, 2001Date of Patent: July 1, 2003Assignee: Merck & Co., Inc.Inventors: Thomas Shih, Steven L. Colletti, Michael H. Fisher, Peter T. Meinke, Howard C. H. Kuo, Prasun K. Chakravarty, Matthew J. Wyvratt, Sriram Tyagarajan, Richard Berger
-
Patent number: 6583089Abstract: Tricyclic benzoylcyclohexanedione derivatives of the formula I where X, Y, R1, R2, R3, R4, R5, R9, and m are defined herein, and their agriculturally useful salts. Process for preparing the tricyclic benzoylcyclohexanedione derivatives; compositions comprising them and the use of these derivatives or of the compositions comprising them for controlling undesirable plants are described.Type: GrantFiled: November 29, 2001Date of Patent: June 24, 2003Assignee: BASF AktiengesellschaftInventors: Matthias Witschel, Steffen Kudis, Klaus Langemann, Ernst Baumann, Wolfgang von Deyn, Guido Mayer, Ulf Misslitz, Ulf Neidlein, Martina Otten, Karl-Otto Westphalen, Helmut Walter
-
Publication number: 20030114432Abstract: The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.Type: ApplicationFiled: September 19, 2002Publication date: June 19, 2003Inventors: Michael Clare, Joyce Z. Crich, Timothy J. Hagen, Gunnar J. Hanson, Stephen C. Houdek, He Huang, Richard M. Weier
-
Publication number: 20030109562Abstract: Compounds of the formula: 1Type: ApplicationFiled: January 10, 2003Publication date: June 12, 2003Applicant: WyethInventors: Megan Tran, Gary P. Stack
-
Publication number: 20030091861Abstract: Disclosed is a material for a light emitting device excellent in color purity, good in light emitting characteristics and excellent in stability, which consists of a compound represented by the following general formula (I):Type: ApplicationFiled: August 21, 2002Publication date: May 15, 2003Applicant: FUJI PHOTO FILM CO., LTD.Inventors: Hisashi Okada, Toshihiro Ise
-
Publication number: 20030088109Abstract: The invention relates to fluorescent dyes. More particularly, the invention relates to fluorescent cyanine dyes, and especially to water soluble fluorescent cyanine dyes that contain additional sites for attachment to biomolecules. The invention provides a group of novel, water soluble fluorescent cyanine dyes that have distinct fluorescence characteristics that permit their use in any assay or method suited to water soluble fluorescent dyes, and especially to assays requiring a plurality of distinguishable fluorescent markers. The invention further relates to nucleotides, nucleosides, polynucleotides and polypeptides labeled with novel fluorescent cyanine dyes according to the invention, and methods of using them.Type: ApplicationFiled: February 28, 2002Publication date: May 8, 2003Applicant: StratageneInventors: Jack Anderson, Jeffrey Carl Braman
-
Publication number: 20030073697Abstract: Compounds of the formula 1Type: ApplicationFiled: April 25, 2002Publication date: April 17, 2003Applicant: WyethInventors: Megan Tran, Gary P. Stack
-
Patent number: 6548530Abstract: Analogs of the antitumor antibiotics CC-1065 and the duocarmycins incorporate the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) alkylation subunit. The CBI-based analogs have potent cytotoxic activity and are useful as efficacious antitumor compounds. A direct relationship between functional stability and in vitro cytotoxic potency is disclosed. The CBI-based analogs are easily synthesized and are 4× more stable and 4× more potent than the corresponding analogs containing the authentic CPI alkylation subunit of CC-1065 and comparable in potency to agents containing the authentic alkylation subunit of duocarmycin SA. Similarly, the CBI-based agents alkylate DNA with an unaltered sequence selectivity at an enhanced rate and with a greater efficiency than the corresponding CPI analog and were comparable to the corresponding analog incorporating the duocarmycin SA alkylation subunit.Type: GrantFiled: October 2, 1998Date of Patent: April 15, 2003Assignee: The Scripps Research InstituteInventor: Dale L. Boger
-
Patent number: 6534506Abstract: The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.Type: GrantFiled: April 6, 2001Date of Patent: March 18, 2003Assignee: Merck & Co., Inc.Inventors: Diem N. Nguyen, Craig A. Stump, Theresa M. Williams
-
Publication number: 20030004355Abstract: A fused pyrazolyl compound of the following formula: 1Type: ApplicationFiled: January 24, 2002Publication date: January 2, 2003Inventors: Che-Ming Teng, Sheng-Chu Kuo, Fang Yu Lee
-
Patent number: 6461747Abstract: Disclosed is a material for a light emitting device excellent in color purity, good in light emitting characteristics and excellent in stability, which consists of a compound represented by the following general formula (I): L&Parenopenst;A)m (I) wherein A represents a heterocyclic group in which two or more aromatic heterocycles are condensed; m represents an integer of 2 or more, and the heterocyclic groups represented by A may be the same or different; and L represents a connecting group.Type: GrantFiled: July 21, 2000Date of Patent: October 8, 2002Assignee: Fuji Photo Co., Ltd.Inventors: Hisashi Okada, Toshihiro Ise
-
Patent number: 6451988Abstract: Novel naphthol derivatives, and various azo compounds and metal complexes prepared by using the derivatives are provided. The instant invention provides naphthol derivatives represented by general formula (1); wherein at least one of Y1 and Y2 is a group represented by formula (2); wherein X1 is —O—, —S— or —NH—; and Z is an optionally substituted aromatic group or heterocyclic group having conjugated double bonds, and salts thereof; mono-, bis-, and trisazo compounds prepared from the derivatives; and metal complexes containing the derivatives as the ligand.Type: GrantFiled: January 16, 2002Date of Patent: September 17, 2002Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Masaya Kitayama, Kenji Minami, Hiroyuki Wakamori
-
Patent number: 6417213Abstract: A compound of the formula wherein R1 is H or a substituent; m is 1-3; Ar is an aromatic group which may be substituted; X is a bond or a divalent straight-chain group having 1-6 atoms which may be substituted; Y is —S—, —O—, or —N(R2)— (R2 is H or a substituent group), Z is —N═ or —C(R3)═ (R3 is H or a hydrocarbon group), ring A is a benzene ring; ring B is a 5- to 7-membered ring which may be substituted, or a salt thereof is useful for eliciting a prostaglandin I2 receptor agonistic effect.Type: GrantFiled: March 7, 2001Date of Patent: July 9, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Shigenori Ohkawa, Masaki Setoh, Zen-ichi Terashita
-
Publication number: 20020072612Abstract: The present invention provides a novel 7a-alkoxy-4H-pyrano-[3,2-d]-oxazol-2(3H)-one represented by the formula (I): 1Type: ApplicationFiled: November 16, 2001Publication date: June 13, 2002Inventors: Hiroyuki Miyata, Takashi Honma, Yasuhito Yamamoto, Kikuo Ataka
-
Patent number: 6380228Abstract: The present invention is directed to peptidomimetic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.Type: GrantFiled: April 6, 2001Date of Patent: April 30, 2002Assignee: Merck & Co., Inc.Inventors: Craig A. Stump, Theresa M. Williams
-
Publication number: 20020049242Abstract: A compound represented by the formula: 1Type: ApplicationFiled: May 3, 2001Publication date: April 25, 2002Inventors: Tsuneo Yasuma, Tsuneo Oda, Masatoshi Hazama, Shigehisa Taketomi
-
Publication number: 20020045759Abstract: The present invention is directed to peptidomimetic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.Type: ApplicationFiled: April 6, 2001Publication date: April 18, 2002Inventors: Craig A. Stump, Theresa M. Williams
-
Patent number: 6365610Abstract: The invention provides a urokinase production inhibitor or angiogenesis inhibitor comprising as an active component an ozonide derivative represented by the formula (1), and method of prevention or therapy using the inhibitor wherein A is an oxygen atom or N—R (wherein R is phenyl or phenyl having as a substituent lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom); B is an oxo group or —R4; and (1) when A is an oxygen atom, R1 is a hydrogen atom, etc., R2 is phenyl, etc., R3 is a hydrogen atom, etc., B is an oxo group or —R4, R4 is a hydrogen atom, etc., R5 is a hydrogen atom, etc.; (2) when A is N—R, R1 is a hydrogen atom, etc., R2 is a hydrogen atom, etc., R3 is a hydrogen atom, etc., B is —R4, R4 is a hydrogen atom, etc., R5 is a hydrogen atom, etc.Type: GrantFiled: March 28, 2000Date of Patent: April 2, 2002Assignee: Taiho Pharmaceutical Company Ltd.Inventors: Takuma Sasaki, Masatomo Nojima
-
Patent number: 6352983Abstract: Novel compounds of the formula wherein the substituents are defined as in the application having antibiotic properties.Type: GrantFiled: October 8, 1999Date of Patent: March 5, 2002Assignee: Aventis Pharma S.A.Inventors: Constantin Agouridas, Francois Bretin, Alexis Denis, Claude Fromentin
-
Patent number: 6294564Abstract: The invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and Y have the meanings given in the description. Said compounds are novel active bronchial therapeutic agents.Type: GrantFiled: November 1, 2000Date of Patent: September 25, 2001Assignee: Byk Gulden Lomberg Chemische Fabrik GmbHInventor: Thomas Bär
-
Patent number: 6245796Abstract: A tricyclic pyrrole or pyrazole derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof, which shows strong affinity and selectivity for the 5-HT2C receptor and is useful for the treatment of central nervous system diseases such as sexual disorders, eating disorders, anxiety, depression and sleeping disorders. (In the above formula, each symbol means as follows; Y ring: an unsaturated five-membered ring which may have 1 to 3 of one or more types of hetero atom(s) each selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom or an unsaturated six-membered ring having 1 or 2 nitrogen atom(s), X: a bond or a carbon atom, a double bond or a single bond, V: a nitrogen atom or a group represented by a formula CH, and A: a straight or branched lower alkylene group which may be substituted with a halogen atom or a cycloalkyl group).Type: GrantFiled: December 2, 1999Date of Patent: June 12, 2001Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kyoichi Maeno, Ken-ichi Kazuta, Hideki Kubota, Itsuro Shimada, Tetsuya Kimizuka, Shuichi Sakamoto, Fumikazu Wanibuchi
-
Patent number: RE39743Abstract: Novel compounds of the formula wherein the substituents are defined as in the application having antibiotic properties.Type: GrantFiled: November 21, 2002Date of Patent: July 24, 2007Assignee: Aventis Pharma S.A.Inventors: Constantin Agouridas, Francois Bretin, Alexis Denis, Claude Fromentin