At Least Four Rings In The Polycyclo Ring System Patents (Class 548/223)
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Patent number: 12041850Abstract: Polycyclic aromatic hydrocarbon derivatives represented by the following general formula: (I) wherein R independently represents an aromatic group and/or an aliphatic group; Q is one of a cyclic aliphatic hydrocarbon, a cyclic aromatic hydrocarbon, a polycyclic hydrocarbon, a polycyclic aromatic hydrocarbon, and/or a fused polycyclic aromatic hydrocarbon; wherein the substituents independently comprise one or more of a hydrogen atom, a deuterium atom, a fluorine atom, a chlorine atom, a bromine atom, a carbon atom, an oxygen atom (e.g. an alkylated oxygen atom), a nitrogen atom (e.g. an alkylated nitrogen atom), a cyano group, a nitro group, an alkyl group and/or an aryl group; p is an integer of 1 to 2; q is an integer of 1 to 4; Y1 and Y2 independently represent one or more of a hydrogen atom, a deuterium atom, a fluorine atom, a chlorine atom, a bromine atom, a carbon atom, an oxygen atom (e.g. an alkylated oxygen atom), a nitrogen atom (e.g.Type: GrantFiled: March 21, 2019Date of Patent: July 16, 2024Assignee: CHROMATWIST LIMITEDInventors: Alex Robinson, Jon Preece, Gregory O'Callaghan, Karolis Virzbickas, Owen Jones, Dennis Zhao, Michael Butlin, Sareena Sund
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Publication number: 20140252324Abstract: Provided is an organic light-emitting diode including a compound of Formula 1 below: wherein a detailed description of a substituent in Formula 1 above is defined as described in the detailed description.Type: ApplicationFiled: August 5, 2013Publication date: September 11, 2014Inventor: Jung-Sub LEE
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Publication number: 20140027755Abstract: The present invention relates to an electronic device comprising one or more compounds of a formula (I) or (II). Furthermore, the invention encompasses the use of a compound of the formula (I) or (II) in an electronic device, and the provision of certain compounds of the formula (I) or (II).Type: ApplicationFiled: March 15, 2012Publication date: January 30, 2014Applicant: Merck Patent GmbH Patents & Scientific InformationInventors: Teresa Mujica-Fernaud, Christof Pflumm, Irina Martynova
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Patent number: 8618307Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.Type: GrantFiled: September 15, 2010Date of Patent: December 31, 2013Assignee: Calcimedica, Inc.Inventors: Jeffrey P. Whitten, Yazhong Pei, Jianguo Cao, Zhijun Wang, Evan Rogers
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Publication number: 20110065762Abstract: The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses.Type: ApplicationFiled: September 13, 2010Publication date: March 17, 2011Inventors: Jizhou Wang, Xiaodong Fan, Lidia Cristian
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Publication number: 20100249349Abstract: The present invention relates to novel polymers comprising a repeating unit of the formula (I) and their use in electronic devices. The polymers according to the invention have excellent solubility in organic solvents and excellent film-forming properties. In addition, high charge carrier mobilities and high stability of the emission color can be observed, if the polymers according to the invention are used in organic light emitting diodes (OLEDs).Type: ApplicationFiled: January 31, 2007Publication date: September 30, 2010Inventors: Natalia Chebotareva, Roger Prétôt, Paul Adriaan Van Der Schaaf, Thomas Schäfer, Beat Schmidhalter, Peter Murer
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Publication number: 20100039024Abstract: The present invention relates electroluminescent devices, comprising a compound of the formula (I), especially as host for phosphorescent compounds. The hosts may function with phosphorescent materials to provide improved efficiency, stability, manufacturability, or spectral characteristics of electroluminescent devices.Type: ApplicationFiled: September 4, 2007Publication date: February 18, 2010Inventors: Frédérique Wendeborn, Beat Schmidhalter, Thomas Schäfer, Peter Murer, Kristina Bardon
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Publication number: 20090105447Abstract: The present invention relates to polymers comprising a repeating unit of the formula (I), and their use in electronic devices. The polymers according to the invention have excellent 5 solubility in organic solvents and excellent film-forming properties. In addition, high charge carrier mobilities and high temperature stability of the emission color are observed, if the polymers according to the invention are used in polymer light emitting diodes (PLEDs).Type: ApplicationFiled: March 8, 2006Publication date: April 23, 2009Inventors: Thomas Schafer, Beat Schmidhalter, Peter Murer, Kristina Bardon, Tobias Hintermann
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Publication number: 20080177080Abstract: This invention provides compounds of the formula: wherein A?, X and Y are defined in the specification. These compounds are useful as antibacterial agents.Type: ApplicationFiled: March 24, 2008Publication date: July 24, 2008Applicant: WyethInventors: Phaik-Eng Sum, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini
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Patent number: 7365087Abstract: This invention provides compounds of the formula: wherein A?, X and Y are defined in the specification. These compounds are useful as antibacterial agents.Type: GrantFiled: December 13, 2006Date of Patent: April 29, 2008Assignee: WyethInventors: Phaik-Eng Sum, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini
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Patent number: 7176225Abstract: This invention provides compounds of the formula: wherein A?, X and Y are defined in the specification. These compounds are useful as antibacterial agents.Type: GrantFiled: December 8, 2004Date of Patent: February 13, 2007Assignee: WyethInventors: Phaik-Eng Sum, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini
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Patent number: 7166715Abstract: The invention provides an asymmetric cyanine dye compound having the structure including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labelled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labelled polynucleotides.Type: GrantFiled: May 5, 2004Date of Patent: January 23, 2007Assignee: Applera CorporationInventors: Linda G. Lee, Ronald J. Graham, Khairuzzaman B. Mullah, Francis T. Haxo
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Patent number: 6750024Abstract: The invention provides an asymmetric cyanine dye compound having the structure including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labelled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labelled polynucleotides.Type: GrantFiled: March 31, 2003Date of Patent: June 15, 2004Assignee: Applera CorporationInventors: Linda G. Lee, Ronald J. Graham, Khairuzzaman B. Mullah, Francis T. Haxo
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Patent number: 6660732Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.Type: GrantFiled: September 25, 2001Date of Patent: December 9, 2003Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Rajashehar Betageri, Steffen Breitfelder, Pier F. Cirillo, Thomas A. Gilmore, Eugene R. Hickey, Thomas M. Kirrane, Monica H. Moriak, Neil Moss, Usha R. Patel, John R. Proudfoot, John R. Regan, Rajiv Sharma, Sanxing Sun, Alan D. Swinamer, Hidenori Takahashi
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Patent number: 6656933Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.Type: GrantFiled: September 25, 2001Date of Patent: December 2, 2003Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventor: Eugene R. Hickey
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Patent number: 6541618Abstract: The invention provides an asymmetric cyanine dye compound having the structure including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labelled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labelled polynucleotides.Type: GrantFiled: June 21, 2000Date of Patent: April 1, 2003Assignee: Applera CorporationInventors: Linda G. Lee, Ronald J. Graham, Khairuzzaman B. Mullah, Francis T. Haxo
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Patent number: 6407127Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as defined in the specification. These compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).Type: GrantFiled: April 13, 2001Date of Patent: June 18, 2002Assignees: Novo Nordisk A/S, Dr. Reddy's Research foundationInventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
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Patent number: 6350431Abstract: This invention provides a physiologically tolerable light imaging contrast agent compound having a molecular weight in the range 500 to 5000000 and containing at least two chromophores having delocalized electron systems as well as at least one polyalkylene oxide (PAO) moiety having a molecular weight in the range 60 to 100000.Type: GrantFiled: October 28, 1999Date of Patent: February 26, 2002Assignee: Nycomed Imaging ASInventors: Robert Allen Snow, Paul Mark Henrichs, Daniel Joseph Delecki, William Anthony Sanderson, Vinay Chandrakant Desai, Edward Bacon, Kenneth Robert Hollister, Eric Paul Hohenschuh
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Publication number: 20010021710Abstract: The present invention relates to therapeutically active compounds of formula I 1Type: ApplicationFiled: October 27, 1997Publication date: September 13, 2001Inventors: POUL JACOBSEN, SVEND TREPPENDAHL, PAUL STANLEY BURY, ANDERS KANSTRUP, LISE BROWN CHRISTIANSEN
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Patent number: 6080868Abstract: The invention provides an asymmetric cyanine dye compound having the structure ##STR1## including substituted forms thereof, wherein, at least one of R.sub.1 and R.sub.2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labeled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labeled polynucleotides.Type: GrantFiled: January 23, 1998Date of Patent: June 27, 2000Assignee: The Perkin-Elmer CorporationInventors: Linda G. Lee, Ronald J. Graham, Khairuzzaman B. Mullah, Francis T. Haxo
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Patent number: 5998437Abstract: The present invention provides novel benzimidazole derivatives or salts thereof represented by the general formula, ##STR1## wherein R.sup.1 is a hydrogen atom or a halogen atom; R.sup.2 is a phenyl-lower alkyl group; R.sup.3 is a heterocyclic group selected from the group consisting of an indolyl group, indolinyl group, 1H-indazolyl group, 2(1H)-quinolinonyl group, 3,4-dihydro-2(1H)-quinolinonyl group and 1,4-benzoxazinyl group; A is a lower alkylene group; n is 0 or 1.The benzimidazole derivatives or salts of the present invention are effective agents for treating various arteriosclerotic diseases.Type: GrantFiled: March 6, 1997Date of Patent: December 7, 1999Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Takao Nishi, Seiji Sato, Takeshi Nagatani, Hirotaka Yukawa, Nobuyuki Koga, Masahiro Saito, Shinji Yoshinaga
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Patent number: 5703065Abstract: The invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein A, W, P, R.sup.3, Q and R.sup.1 are as defined herein. The compounds of formula I, and pharmaceutically acceptable salts thereof, are substance P antagonists and as such are useful in the treament of various inflammatory and central nervous system disorders.Type: GrantFiled: May 7, 1996Date of Patent: December 30, 1997Assignee: Pfizer Inc.Inventor: Harry R. Howard, Jr.
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Patent number: 5703104Abstract: Compounds, topical compositions and methods useful for preventing the penetration of toxic chemicals through the skin of a mammal are disclosed.The compounds of the invention provide an enhanced barrier for the skin of a mammal to further inhibit or decrease the passage of bioactive agents through the skin of a mammal either from the outside environment into the systems of said mammal or from the mammal into the outside environment.Type: GrantFiled: July 3, 1996Date of Patent: December 30, 1997Assignee: Durham Pharmaceuticals LLCInventors: James V. Peck, Gevork Minaskanian, Mark C. Sleevi
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Patent number: 5576343Abstract: An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: ##STR1## wherein the group represented by ##STR2## is a group selected from indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, naphthyl, tetrahydronaphthyl and indanyl; X is a single bond, an oxygen atom, a sulfur atom or a carbonyl group; and Y is a saturated or unsaturated 5- or 6-membered heterocyclic moiety or cyclic hydrocarbon moiety optionally having a substituent group, an amino group optionally having a substituent group or an aminoalkyl group optionally having a substituent group.The inventive compound has a high anticoagulant capacity based on its excellent FXa inhibition activity.Type: GrantFiled: June 6, 1995Date of Patent: November 19, 1996Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Takayasu Nagahara, Naoaki Kanaya, Kazue Inamura, Yukio Yokoyama
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Patent number: 5569655Abstract: Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.Type: GrantFiled: July 29, 1994Date of Patent: October 29, 1996Assignee: Sterling Winthrop Inc.Inventors: John A. Dority, Jr., William G. Earley, Virendra Kumar, John P. Mallamo, Matthew S. Miller, Chakrapani Subramanyam
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Patent number: 5204467Abstract: Photopolymerizable compositions containing photoinitiator systems that absorb in the visible are disclosed.Type: GrantFiled: December 20, 1991Date of Patent: April 20, 1993Assignee: E. I. Du Pont de Nemours and CompanyInventor: William K. Smothers
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Patent number: 5091501Abstract: This invention provides a process for producing 2H-1-benzopyran-2-ones (coumarins) from optionally-substituted o-halocinnamic acids or esters under polyester-forming conditions. When the coumarins contain appropriately reactive functional groups, and desired monomers are present, a colored or UV-absorbing coumarin/polyester copolymer is provided in one step.Type: GrantFiled: October 4, 1990Date of Patent: February 25, 1992Assignee: Eastman Kodak CompanyInventors: Max A. Weaver, Samuel D. Hilbert, Wayne P. Pruett, Clarence A. Coates, Jr.
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Patent number: 5059598Abstract: Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 is a lower alkyl group;R.sup.2 and R.sup.3 are each hydrogen or lower alkyl or R.sup.2 and R.sup.3 taken together may form --(CH.sub.2).sub.4 -- or --CH.dbd.CH--CH.dbd.CH--;.alpha. is a 5- or 6-membered heretoaromatic ring group containing 1 to 3 hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur, or a pyrazine-N-oxide ring, pyridazine-N-oxide ring or pyrimidine -N-oxide ring group, wherein each of these heteroaromatic ring groups may optionally have 1 to 3 substituents selected from the group consisting of a lower alkyl halogen, phenyl, lower alkoxycarbonyl, amino, lower alkoxy and hydroxy-lower alkyl, with the proviso that said 5- or 6-membered heteroaromatic ring group is not thiazolyl, isothiazolyl, pyridyl or 1,3,5-triazinyl group; or salts thereof. These compounds and salts thereof have anti-inflammatory activity and lipoxygenase-inhibitory activity.Type: GrantFiled: September 19, 1989Date of Patent: October 22, 1991Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Kenichi Kanai, Kiyoto Goto, Kinji Hashimoto
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Patent number: 4764622Abstract: A light-collecting system, which contains a coumarin derivative of the formula ##STR1## in which T denotes O or NR.sub.4,R.sub.4 represents hydrogen, optionally substituted aryl, cycloalkyl or aralkyl,R.sub.1 denotes a carbocyclic or heterocyclic 5 or 6 membered ring bonded via a C.atom, or a 5 or 6 membered heterocyclic ring which is bonded via a N atom and is rotationally asymmetrical to an axis placed through the coumarin/N-heterocyclic bond, the 5 or 6 membered rings may carry non-ionic substituents and for an optionally substituted benzene ring or naphthalene ring to be fused to the said rings;X signifies ##STR2## or --OR.sub.2 ', R.sub.2 represents hydrogen, alkyl, cycloalkyl, aralkyl or aryl, hydrocarbon radicals may be substituted, andR.sub.3, in addition to having the definitions given for R.sub.2, also signifies a radical of the formulaeR.sub.6 --(X).sub.n --CO-- or R.sub.7 --(X).sub.n --SO.sub.2 --R.sub.6 and R.sub.Type: GrantFiled: October 17, 1986Date of Patent: August 16, 1988Assignee: Bayer AktiengesellschaftInventors: Uwe Claussen, Horst Harnisch
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Patent number: 4552684Abstract: An anthraquinonic dye of the formula ##STR1## is provided. When used as dichloric dyes in liquid crystalline color display elements, these dyes (1) have sufficient coloring ability in small amounts, (2) have a high dichloric ratio, (3) are fully soluble in liquid crystals, and (4) have excellent durability, are stable and do not degrade the performance of a display device upon long-term use.Type: GrantFiled: March 7, 1984Date of Patent: November 12, 1985Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Yasuyuki Yamada, Tsutomu Nishizawa, Tamio Mikoda, Tooru Miyahara, Masaharu Kikutsugi
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Patent number: 4482563Abstract: 3-Nitro-2-substituted aminopyrroles are histamine H.sub.2 - receptor antagonists. The 2- position substituent is a fully-unsaturated heterocyclyl alkyl group preferably with alkyl group interrupted by sulfur or oxygen. The 4- and 5- positions of the pyrrole ring can also be substituted.Type: GrantFiled: June 27, 1983Date of Patent: November 13, 1984Assignee: Smith Kline & French Laboratories LimitedInventors: Michael L. Roantree, Rodney C. Young