Chalcogen Or Nitrogen Attached Directly To The Tetrazole Ring By Nonionic Bonding Patents (Class 548/251)
  • Patent number: 10501408
    Abstract: The present invention discloses processes for producing a thiol compound or a sulfide compound from an olefin compound. Diphenylamine or a phenol compound can be used to increase the rate of conversion of the olefin compound to the thiol compound or the sulfide compound.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: December 10, 2019
    Assignee: Chevron Phillips Chemical Company LP
    Inventor: Kenneth M. Lassen
  • Patent number: 10189779
    Abstract: The present invention discloses processes for producing a thiol compound or a sulfide compound from an olefin compound. Diphenylamine or a phenol compound can be used to increase the rate of conversion of the olefin compound to the thiol compound or the sulfide compound.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: January 29, 2019
    Assignee: Chevron Phillips Chemical Company, LP
    Inventor: Kenneth M. Lassen
  • Patent number: 9670168
    Abstract: Described are methods for preparing salts of 5-nitrotetrazolate that include reacting aqueous solutions of 5-aminotetrazole, an acid, and sodium nitrite in a continuous flow system at an elevated temperature.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: June 6, 2017
    Assignee: Pacific Scientific Energetic Materials Company
    Inventors: Jon G. Bragg, John W. Fronabarger, Michael D. Williams
  • Patent number: 9512113
    Abstract: N-(Tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxylic acid thioamides of the general formula (I) are described as herbicides. In this formula (I), R, W, X and Z represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. A and B each represent carbon or nitrogen.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: December 6, 2016
    Assignee: Bayer Cropscience AG
    Inventors: Ralf Braun, Simon Doerner-Rieping, Hartmut Ahrens, Arnim Koehn, Christian Waldraff, Hansjoerg Dietrich, Dirk Schmutzler, Elmar Gatzweiler, Christopher Hugh Rosinger
  • Patent number: 9259001
    Abstract: 5-phenyl-substituted N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of the general formula (I) are described as herbicides. In this formula (I), W, X, Y, Z and R are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. A and B are N and CY.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: February 16, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Ralf Braun, Hartmut Ahrens, Andreas Van Almsick, Stefan Lehr, Isolde Häuser-Hahn, Hansjörg Dietrich, Elmar Gatzweiler, Ines Heinemann, Christopher Hugh Rosinger
  • Patent number: 9204650
    Abstract: N-(1,2,5-Oxadiazol-3-yl)-, N-(1,3,4-oxadiazol-2-yl)-, N-(tetrazol-5-yl)- or N-(triazol-5 -yl)arylcarboxamides of the general formula (I) are described as herbicides. In this formula (I), R, V, X, Y and Z are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. Q is a tetrazolyl, triazolyl or oxadiazolyl radical. W is CY or N.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: December 8, 2015
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Armin Koehn, Stefan Lehr, Ralf Braun, Simon Doerner-Rieping, Hartmut Ahrens, Hansjoerg Dietrich, Isolde Haeuser-Hahn, Christopher Hugh Rosinger, Elmar Gatzweiler
  • Publication number: 20150105253
    Abstract: Salts of N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of the general formula (I) are described as herbicides. In this formula (I), W, X, Z and R represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. A and B each represent nitrogen or carbon. M+ represents a cation.
    Type: Application
    Filed: April 30, 2013
    Publication date: April 16, 2015
    Applicant: Bayer Cropscience AG
    Inventors: Ralf Braun, Simon Doerner-Rieping, Hartmut Ahrens, Christian Waldraff, Arnim Koehn, Hansjoerg Dietrich, Elmar Gatzweiler, Christopher Hugh Rosinger
  • Publication number: 20150087519
    Abstract: N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of formula I and their use as herbicides, The invention relates to N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of formula I and their use as herbicides. In said formula I, B represents N or CH, whereas R, R1, R2, R3, R4 and R5 represent groups such as hydrogen, halogen or organic groups such as alkyl or phenyl.
    Type: Application
    Filed: April 16, 2013
    Publication date: March 26, 2015
    Inventors: Helmut Kraus, Matthias Witschel, Thomas Seitz, Trevor William Newton, Liliana Parra Rapado, Klaus Kreuz, Johannes Hutzler, Maciej Pasternak, Jens Lerchl, Richard Roger Evans
  • Patent number: 8975288
    Abstract: A compound or its pharmaceutically acceptable salt, as well as a pharmaceutical, composition containing that compound or salt dissolved or dispersed in a pharmaceutically acceptable carrier, and a method of using that compound or salt in an antibacterial treatment. A contemplated compound corresponds in structure to structural Formula I or a pharmaceutically acceptable salt of that compound, wherein V is O or NR9, Y is halogen, OR10, C1-C4 hydrocarbyl or NHR10, Z is NR2—X—R1 or CH2—R8, n is 1-6, X is H, S(O)2, C(O), C(O)NR7, C(NH)NR7 or C(O)O, and R1, R2, R7, R8, R9 and R10 are defined within.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 10, 2015
    Assignee: The Penn State Research Foundation
    Inventors: Kenneth Charles Keiler, John Nandwa Alumasa
  • Patent number: 8962667
    Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: February 24, 2015
    Assignee: Microdose Therapeutix, Inc.
    Inventors: Theodore J. Nitz, Janet A. Gaboury, Christopher J. Burns, Sylvie Laquerre, Daniel C. Pevear, Thomas A. Lessen, David J. Rys
  • Publication number: 20150051171
    Abstract: The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1): [wherein R1 represents an C6-C16 aryl group, an C1-C12 alkyl group, or a C3-C12 cycloalkyl group, etc., which each optionally be substituted; R2, R3, R4 and R5 represent independently of each other a hydrogen atom, a halogen atom or an C1-C3 alkyl group, etc.; R6 represents an C1-C6 alkyl group, a C3-C6 cycloalkyl group, a halogen atom, a C1-C6 haloalkyl group, an C2-C6 alkenyl group, an C1-C6 alkoxy group, or a C1-C6 haloalkoxy group, etc.; R7, R8 and R9 represent independently of each other a hydrogen atom, a halogen atom, or an C1-C4 alkyl group, etc.; X represents an oxygen atom or a sulfur atom; and R10 represents an C1-C6 alkyl group, etc.] shows an excellent controlling efficacy on pests.
    Type: Application
    Filed: April 26, 2013
    Publication date: February 19, 2015
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yuya Yoshimoto, Sadayuki Arimori, Yuichi Matsuzaki
  • Patent number: 8957096
    Abstract: What is described are oxime ether-substituted benzoylamides of the general formula (I) as herbicides. In this formula (I), R, Y and Y are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. Q is a tetrazolyl, triazolyl or oxadiazolyl radical.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: February 17, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Andreas Van Almsick, Hartmut Ahrens, Hansjörg Dietrich, Isolde Häuser-Hahn, Ines Heinemann, Elmar Gatzweiler, Christopher Rosinger
  • Publication number: 20150031537
    Abstract: There are described 4-nitro-substituted N-(tetrazol-5-yl)-, N-(triazol-5-yl)- and N-(1,3,4-oxadiazol-2-yl)arylcarboxamides of the general formula (I) as herbicides. In this formula (I), X, Y and W are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. A is N and CY.
    Type: Application
    Filed: February 18, 2013
    Publication date: January 29, 2015
    Inventors: Simon Dörner-Rieping, Ralf Braun, Arnin Köhn, Hartmut Ahrens, Stefan Lehr, Hansjörg Dietrich, Elmar Gatzweiler, Christopher Hugh Rosinger, Dirk Schmutzler
  • Publication number: 20150018210
    Abstract: Sulfinylaminobenzamides of the general formula (I) as herbicides are described. In this formula (I), R, R?, R?, X, W and Z are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. Q is a tetrazolyl, triazolyl or oxadiazolyl radical.
    Type: Application
    Filed: February 18, 2013
    Publication date: January 15, 2015
    Inventors: Hartmut Ahrens, Ralf Braun, Arnim Koehn, Stefan Lehr, Hansjoerg Dietrich, Dirk Schmutzler, Elmar Gatzweiler, Christopher Hugh Rosinger
  • Publication number: 20150018209
    Abstract: The invention relates to sulfin- and sulfonimidoylbenzamides of general formula (S) used as herbicides. In said formula (I), R, R?, R?, X, W and Z represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogens. Q represents a tetrazolyl-, triazolyl or oxadiazolyl radicals.
    Type: Application
    Filed: February 18, 2013
    Publication date: January 15, 2015
    Inventors: Hartmut Ahrens, Ralf Braun, Simon Doerner-Rieping, Arnim Koehn, Stefan Lehr, Hansjoerg Dietrich, Dirk Schmutzler, Elmar Gatzweiler, Christopher HUGH Rosinger
  • Publication number: 20150018399
    Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: August 5, 2014
    Publication date: January 15, 2015
    Inventors: SONGNIAN LIN, Fengqi Zhang, Emma R. Parmee, Sunita V. Dewnani
  • Publication number: 20140378510
    Abstract: Provided herein are small molecule activators of calcium-activated chloride channels. These small molecules may be used for treatment of diseases and disorders that are treatable by activating calcium-activated chloride channels, such as cystic fibrosis, disorders related to salivary gland dysfunction (for example, Sjogren's syndrome and dysfunction following radiation injury), dry eye syndrome, and intestinal hypomotility.
    Type: Application
    Filed: August 3, 2012
    Publication date: December 25, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Alan S. Verkman, Wan Namkung
  • Publication number: 20140371068
    Abstract: N-(1,2,5-Oxadiazol-3-yl)-, N-(1,3,4-oxadiazol-2-yl)-, N-(tetrazol-5-yl)- or N-(triazol-5-yl)arylcarboxamides of the general formula (I) are described as herbicides. In this formula (I), R, V, X, Y and Z are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. Q is a tetrazolyl, triazolyl or oxadiazolyl radical. W is CY or N.
    Type: Application
    Filed: December 10, 2012
    Publication date: December 18, 2014
    Inventors: Armin Koehn, Stefan Lehr, Ralf Braun, Simon Doerner-Rieping, Hartmut Ahrens, Hansjoerg Dietrich, Isolde Haeuser-Hahn, Christopher Hugh Rosinger, Elmar Gatzweiler
  • Publication number: 20140343292
    Abstract: The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament.
    Type: Application
    Filed: December 6, 2012
    Publication date: November 20, 2014
    Inventors: Ben De Lange, Dennis Heemskerk, Karin Henderika Maria Bessembinder
  • Patent number: 8865900
    Abstract: The present invention relates to a process for the preparation of a 1-methyl-1H-tetrazole-5-thio derivative comprising reaction of a halomethyl substrate with 1-methyl-H-tetrazole-5-thiol to obtain a thio-ether compound, and oxidizing the thio-ether compound to the corresponding sulfone. In case of a chiral halomethyl substrate, the resulting chiral diol sulfone derivative is suitable as a building block for statin type compounds.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: October 21, 2014
    Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
    Inventor: Ben De Lange
  • Publication number: 20140309112
    Abstract: What is described are oxime ether-substituted benzoylamides of the general formula (I) as herbicides. In this formula (I), R, Y and Y are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. Q is a tetrazolyl, triazolyl or oxadiazolyl radical.
    Type: Application
    Filed: October 29, 2012
    Publication date: October 16, 2014
    Inventors: Andreas Van Almsick, Hartmut Ahrens, Hansjörg Dietrich, Isolde Häuser-Hahn, Ines Heinemann, Elmar Gatzweiler, Christopher Rosinger
  • Publication number: 20140296245
    Abstract: This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.
    Type: Application
    Filed: October 30, 2012
    Publication date: October 2, 2014
    Inventors: Shaoyi Sun, Alla Yurevna Zenova, Mikhail Chafeev, Qi Jia, Zaihui Zhang, Renata Marcella Oballa
  • Publication number: 20140296069
    Abstract: 5-phenyl-substituted N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of the general formula (I) are described as herbicides. In this formula (I), W, X, Y, Z and R are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. A and B are N and CY.
    Type: Application
    Filed: October 29, 2012
    Publication date: October 2, 2014
    Inventors: Ralf Braun, Hartmut Ahrens, Andreas Van Almsick, Stefan Lehr, Isolde Häuser-Hahn, Hansjörg Dietrich, Elmar Gatzweiler, Ines Heinemann, Christopher Hugh Rosinger
  • Publication number: 20140296292
    Abstract: Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.
    Type: Application
    Filed: November 12, 2012
    Publication date: October 2, 2014
    Inventors: Lin Zhi, Keith Marschke, Virginia H. Grant, Steven L. Roach, Yixing Shen, Jason C. Pickens, Bijan Pedram, C. Arjan van Oeveren, Lino J. Valdez, Andrew R. Hudson
  • Patent number: 8846735
    Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: September 30, 2014
    Assignee: Microdose Therapeutx, Inc.
    Inventors: Theodore J. Nitz, Janet A. Gaboury, Christopher J. Burns, Sylvie Laguerre, Daniel C. Pevear, Thomas A. Lessen, David J. Rys
  • Publication number: 20140275192
    Abstract: A compound or its pharmaceutically acceptable salt, as well as a pharmaceutical, composition containing that compound or salt dissolved or dispersed in a pharmaceutically acceptable carrier, and a method of using that compound or salt in an antibacterial treatment. A contemplated compound corresponds in structure to structural Formula I or a pharmaceutically acceptable salt of that compound, wherein V is O or NR9, Y is halogen, OR10, C1-C4 hydrocarbyl or NHR10, Z is NR2—X—R1 or CH2—R8, n is 1-6, X is H, S(O)2, C(O), C(O)NR7, C(NH)NR7 or C(O)O, and R1, R2, R7, R8, R9 and R10 are defined within.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventors: Kenneth Charles Keiler, John Nandwa Alumasa
  • Publication number: 20140256730
    Abstract: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
    Type: Application
    Filed: January 13, 2014
    Publication date: September 11, 2014
    Applicant: Corsair Pharma, Inc.
    Inventors: Cyrus K. BECKER, Jürg R. PFISTER, Gwenaella RESCOURIO, Meenakshi S. VENKATRAMAN, Xiaoming ZHANG
  • Publication number: 20140251433
    Abstract: In one aspect, an electrolyte for a dye-sensitized solar cell and a dye-sensitized solar cell including the same are provided.
    Type: Application
    Filed: August 20, 2013
    Publication date: September 11, 2014
    Applicant: Samsung SDI Co., Ltd.
    Inventors: Si-Young Cha, Ji-Won Lee, Moon-Sung Kang, Maeng-Eun Lee, Yong-Soo Kang, Woo-Hyung Cho
  • Patent number: 8822378
    Abstract: N-(Tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides and use thereof as herbicides N-(Tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of the general formula (I) are described as herbicides. In this formula (I), X, Y, Z and R represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. A and B represent N and CY.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: September 2, 2014
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Ralf Braun, Simon Dörner-Rieping, Arnim Köhn, Hartmut Ahrens, Stefan Lehr, Andreas Van Almsick, Isolde Häuser-Hahn, Hansjörg Dietrich, Elmar Gatzweiler, Ines Heinemann, Christopher Hugh Rosinger
  • Publication number: 20140242473
    Abstract: Provided is an electrolyte solution for a magnesium battery, containing a mesoionic compound represented by the following general formula (1): (in general formula (1), R1 and R2 are each independently a C1-7 hydrocarbyl group or oxygen-containing hydrocarbyl group and X is O or S).
    Type: Application
    Filed: February 27, 2014
    Publication date: August 28, 2014
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, National University Corporation Nagoya Institute Of Technology
    Inventors: Tsunehisa HIRASHITA, Hirofumi NAKAMOTO
  • Patent number: 8816094
    Abstract: The present invention is a method for promoting hydrothiolation of an unactivated alkenes with a thiol using gallium triflate.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: August 26, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Jimmy Wu, Markku A. Savolainen
  • Publication number: 20140206883
    Abstract: The present invention relates to the field of pharmaceutical chemistry, specifically relates to a statin intermediate having formula I and preparation thereof. The advantages of the method used to prepare the chiral sulfone intermediate having formula I are that a fluorophore is introduced at the beginning of the synthesis, and the intermediates are mostly solid, which enables quality control to be easily carried out.
    Type: Application
    Filed: July 19, 2012
    Publication date: July 24, 2014
    Applicants: YICHANG CHANGJIANG PHARMACEUTICAL CO., LTD., SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Shouhua Zhang, Zhongqing Wang, Zhonghua Luo
  • Publication number: 20140206885
    Abstract: Described are methods for preparing salts of 5-nitrotetrazolate that include reacting aqueous solutions of 5-aminotetrazole, an acid, and sodium nitrite in a continuous flow system at an elevated temperature.
    Type: Application
    Filed: January 22, 2014
    Publication date: July 24, 2014
    Applicant: Pacific Scientific Energetic Materials Company
    Inventors: John W. Fronabarger, Michael D. Williams
  • Publication number: 20140187677
    Abstract: This invention relates to a surface modified silica by an alkyl sulfonated tetrazole compound, a preparation method thereof, and a resin composition containing the same. The silica according to this invention can exhibit superior adhesion to a metal.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 3, 2014
    Applicant: SAMSUNG ELECTRO-MECHANICS CO., LTD.
    Inventors: Young Kwan Seo, Jin Won Lee, Sung Nam Cho, Jun Young Kim, Hyun Jung Lee
  • Patent number: 8765797
    Abstract: Methods and compounds for treating cancer, dmg resistance and/or metastasis are described herein. These methods and compounds can inhibit the expression of aberrant TG2 expression and/or inhibit the binding of GTP to TG2, and thereby prevent the induction of epithelial to mesenchymal transition of cancer cells, and a stem cell-like phenotype.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: July 1, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kapil Mehta, Anupam Kumar, Jansina Fok, Shuxing Zhang
  • Publication number: 20140179527
    Abstract: N-(Tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of the general formula (I) are described as herbicides. In this formula (I), X, Y, Z and R represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. A and B represent N and CY.
    Type: Application
    Filed: July 30, 2012
    Publication date: June 26, 2014
    Applicant: Bayer Intellectual Property Gmbh
    Inventors: Ralf Braun, Simon Dörner-Rieping, Arnim Köhn, Hartmut Ahrens, Stefan Lehr, Andreas Van Almsick, Isolde Häuser, Hansjörg Dietrich, Elmar Gatzweiler, Ines Heinemann, Christopher Hugh Rosinger
  • Patent number: 8759518
    Abstract: A compound of Formula (1), is disclosed wherein P1 and P2 are alcohol protecting groups or 1,3-diol protecting group, R is selected from: wherein R4a is selected from alkyl, aryl, arylalkyl and cycloalkyl, Rc is selected from H, alkyl, aryl, alkaoxy, haloalkyl, monohaloalkyloxy, and dihaloalkyloxy, Rd is selected from alkyl, aryl, arylalkyl, CF3, halo and NO2 and X is selected from O, N—H, N-alkyl and S, Ra and Rb are same or different and each represents hydrogen, an alkyl group of 1 to 12 carbon atoms, an aryl group of 6 to 12 carbon atoms, or an aralkyl group of 7 to 12 carbon atoms.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: June 24, 2014
    Assignee: Cadila Healthcare Limited
    Inventors: Shriprakash Dhar Dwivedi, Dhimant Jasubhai Patel, Mahesh Laljibhai Rupapara
  • Patent number: 8759365
    Abstract: The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: June 24, 2014
    Assignee: Novartis AG
    Inventors: Muneto Mogi, Toshio Kawanami, Ken Yamada, Kayo Yasoshima, Hidetomo Imase, Takahiro Miyake, Osamu Ohmori
  • Publication number: 20140171642
    Abstract: The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.
    Type: Application
    Filed: February 19, 2014
    Publication date: June 19, 2014
    Applicant: BIONOMICS LIMITED
    Inventors: JASON HUGH CHAPLIN, GURMIT SINGH GILL, DAMIAN WOJCIECH GROBELNY, BERNARD LUKE FLYNN, GABRIEL KREMMIDIOTIS
  • Publication number: 20140171657
    Abstract: The invention relates to an energetic active composition comprising a dihydroxylammonium salt or diammonium salt of 5,5?-bistetrazole-1,1?-diol, 5,5?-bistetrazole-1,2?-diol or 5,5?-bistetrazole-2,2?-diol or a mixture of at least two of these salts.
    Type: Application
    Filed: August 16, 2012
    Publication date: June 19, 2014
    Inventors: Thomas M. Klapötke, Niko Fischer, Dennis Fischer, Davin G. Piercey, Jörg Stierstorfer, Marius Reymann
  • Publication number: 20140163032
    Abstract: The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like.
    Type: Application
    Filed: February 18, 2014
    Publication date: June 12, 2014
    Applicant: ARENA PHARMACEUTICALS, INC.
    Inventors: BRADLEY TEEGARDEN, Dennis Chapman, Marc Decaire, Peter I. Dosa, Konrad Feichtinger, HONNAPPA JAYAKUMAR, THUY-ANH Tran, Sonja Strah-Pleynet, Jay Xu
  • Patent number: 8729114
    Abstract: Disclosed are Cathepsin-S reversible inhibitor compounds of the formula (I) which are useful in the treatment of autoimmune and other diseases. Also disclosed are pharmaceutical compositions containing the same, and methods of making and using the same.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: May 20, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Michael J. Burke, Derek Cogan, Donghong Amy Gao, Alexander Heim-Riether, Eugene Richard Hickey, Matthew Russell Netherton, Philip Dean Ramsden, David Charles Thompson, Zhaoming Xiong
  • Publication number: 20140113884
    Abstract: Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
    Type: Application
    Filed: April 4, 2012
    Publication date: April 24, 2014
    Inventors: John David Imig, William B. Campell, John Russell Falck
  • Publication number: 20140106969
    Abstract: N-(1,2,5-Oxadiazol-3-yl)-, N-(tetrazol-5-yl)- and N-(triazol-5-yl)bicycloarylcarboxamides of the general formula (I) are described as herbicides. In this formula (I), R3, R4 and R5 are each radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. Q is a heterocycle. X and Y are each oxygen and sulfur.
    Type: Application
    Filed: March 12, 2012
    Publication date: April 17, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GmbH
    Inventors: Andreas Almsick, Hartmut Ahrens, Arnim Köhn, Simon Dörner-Rieping, Ralf Braun, Isolde Häuser-Hahn, Christopher Hugh Rosinger, Ines Heinemann, Elmar Gatzweiler
  • Publication number: 20140105898
    Abstract: This invention relates generally to methods and agents for modulating adiposity-related conditions. More particularly, the present invention relates to the use of TRAIL death receptor agonists, including nucleic acids such as TRAIL polynucleotides, peptides and polypeptides including TRAIL polypeptides, TRAIL DR agonist antigen-binding molecules, TRAIL DR peptide agonists as well as small molecule TRAIL DR agonists in compositions and methods for treating or preventing adiposity-related conditions such as obesity, diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: February 27, 2012
    Publication date: April 17, 2014
    Applicant: Istituto Di Ricovero E Cura A Carattere Scientific Materno-Infantile Burlo Garo
    Inventors: Merlin C. Thomas, Giorgio Zauli, Paola Secchiero, Bruno Fabris, Stella Bernardi
  • Patent number: 8680119
    Abstract: The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: March 25, 2014
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Bradley Teegarden, Dennis Chapman, Marc Decaire, Peter I. Dosa, Konrad Feichtinger, Honnappa Jayakumar, Thuy-Anh Tran, Sonja Strah-Pleynet, Jingdong Xu
  • Publication number: 20140072532
    Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.
    Type: Application
    Filed: October 11, 2013
    Publication date: March 13, 2014
    Applicant: MICRODOSE THERAPEUTX, INC.
    Inventors: Theodore J. Nitz, Janet A. Gaboury, Christopher J. Burns, Sylvie Laguerre, Daniel C. Pevear, Thomas A. Lessen, David J. Rys
  • Publication number: 20140066630
    Abstract: A process for the preparation of Bis-(1(2)H-tetrazol-5-yl)-amine monohydrate. This preparation process is carried out by the reaction between sodium dicynamide and sodium azide in presence of a dilute solution of an inorganic acid solution in aqueous medium.
    Type: Application
    Filed: March 18, 2013
    Publication date: March 6, 2014
    Inventors: Deevi Sarangapani IYENGAR, Anil SAIKIA, Nagi Reddy BHIMIREDDY
  • Publication number: 20140024530
    Abstract: Use of N-(tetrazol-4-yl)- or N-(triazol-3-yl)arylcarboxamides of formula (I) or salts thereof for controlling unwanted plants in areas of transgenic crop plants being tolerant to HPPD inhibitor herbicides by containing one or more chimeric gene(s) comprising (I) a DNA sequence encoding hydroxyphenylpyruvate dioxygenase (HPPD) derived from a member of a group of organisms consisting of (a) Avena, (b) Pseudomonas, (c) Synechococcoideae, (d) Blepharismidae, (e) Rhodococcus, (f) Picrophilaceae, (g) Kordia, or (II) comprising one or more mutated DNA sequences of HPPD encoding genes of the before defined organisms.
    Type: Application
    Filed: March 21, 2012
    Publication date: January 23, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Fabien Poree, Andreas Almsick, Ralf Braun, Bernd Laber, Ruediger Hain
  • Patent number: RE44721
    Abstract: A method of forming monoammonium salt of 5,5?-bis-1H-tetrazole (BTA-1NH3) is presented comprising the steps of charging a mixing vessel with a solution of free BTA acid and distilled water, adding ammonium hydroxide in excess to obtain a pH of at least 9.5 and mixing the solution, and adding sulfuric acid cooled to 10-20 degrees Celsius to obtain a pH of at least 4.5 and mixing the solution. A gas generator 10 containing a gas generant 12 containing the BTA-1NH3 formed in accordance with the present invention is also presented. Gas generating systems 180 such as vehicle occupant protection systems 180, containing the gas generator 10, are also provided.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: January 21, 2014
    Assignee: TK Holdings Inc.
    Inventors: Deborah L. Hordos, Sean P. Burns