Polycyclo Ring System Having The Triazole Ring As One Of The Cyclos Patents (Class 548/257)
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Patent number: 12054830Abstract: A system and method for coating a foil mesh with a no-chrome conversion coating is provided, wherein the system includes a solution tank, wherein the solution tank defines a tank cavity for containing a conversion coating solution, wherein the conversion coating solution comprises at least one of 5% butyl benzotriazole sodium salt and 7% alodine 5200. The system further includes a reel/roller system configured to cause the foil mesh to be disposed within the conversion coating solution for a predetermine period of time.Type: GrantFiled: June 15, 2021Date of Patent: August 6, 2024Assignee: ASTROSEAL PRODUCTS MFG CORPORATIONInventors: Michael Milardo, John Sulzbach
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Patent number: 11981793Abstract: An ultraviolet radiation absorbing composition can be used as a light stabilizer for a shaped artificial polymer article, wherein the polymer is a synthetic polymer and/or a natural elastomer and wherein the ultraviolet radiation absorbing composition includes the compound of formula (I) wherein n and m are independently 0 to 20, and at least one of m and n being ?1; and X1, X2, X3, X4 and X5 are the same or different and are independently selected from H, C(O)R1 with R1 being C8-C24-alkyl, or a group of the general formula (II) wherein R2 is H or halogen.Type: GrantFiled: April 1, 2019Date of Patent: May 14, 2024Assignee: BASF SEInventors: Thomas Ehlis, Heinz Herbst, Daniel Mueller, Manuele Vitali, Gregor Huber
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Patent number: 10752720Abstract: Described are high energy light blocking compounds and ophthalmic devices containing the compounds. In particular, described are hydroxybiphenyl benzotriazole structures with polymerizable functionality that block high energy light and are visibly transparent. The hydroxybiphenyl benzotriazole structures can be incorporated into ophthalmic devices, such as hydrogel contact lenses, to protect eyes from high energy light radiation.Type: GrantFiled: May 15, 2018Date of Patent: August 25, 2020Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Shivkumar Mahadevan, Leilani K. Sonoda, Dola Sinha, Patricia Martin
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Patent number: 9960294Abstract: The invention provides highly fluorescent materials comprising a compound of formula (I): The chromophores are particularly useful for absorption and emission of photons in the visible and near infrared wavelength range. The photo-stable highly luminescent chromophores are useful in various applications, including in wavelength conversion films. Wavelength conversion films have the potential to significantly enhance the solar harvesting efficiency of photovoltaic or solar cell devices.Type: GrantFiled: January 3, 2014Date of Patent: May 1, 2018Assignee: Nitto Denko CorporationInventors: Mila Rachwal, Michiharu Yamamoto
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Patent number: 9914720Abstract: The invention relates to crystalline forms of (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone, processes for the preparation thereof, pharmaceutical compositions containing such crystalline forms, pharmaceutical compositions prepared from such crystalline forms, and their use as a medicament, especially as orexin receptor antagonists.Type: GrantFiled: December 2, 2014Date of Patent: March 13, 2018Assignee: IDORSIA PHARMACEUTICALS LTDInventors: Christoph Boss, Christine Brotschi, Markus Gude, Bibia Heidmann, Thierry Sifferlen, Markus Von Raumer, Jodi T. Williams
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Patent number: 9802905Abstract: A process for removing impurities from a liquid azole heteroaromatic compound-containing (e.g., triazole-containing) mixture by: (a) providing a liquid azole heteroaromatic compound-containing mixture having impurities; and (b) passing the azole heteroaromatic compound-containing mixture through at least one filtration membrane which is a nanofiltration membrane and/or ultrafiltration membrane having a molecular pore size in the range of from about 200 daltons to about 1 kilodaltons to provide a permeate that is an at least partially purified azole heteroaromatic compound-containing mixture and a retentate with at least some impurities.Type: GrantFiled: March 23, 2016Date of Patent: October 31, 2017Assignee: Wincom, Inc.Inventors: Peter F. Vogt, James E. Milawski, Michael E. Lees, Alexander J. Wessel
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Patent number: 9309205Abstract: A process for removing impurities from a liquid azole heteroaromatic compound-containing (e.g., triazole-containing) mixture by: (a) providing a liquid azole heteroaromatic compound-containing mixture having impurities; and (b) passing the azole heteroaromatic compound-containing mixture through at least one filtration membrane which is a nanofiltration membrane and/or ultrafiltration membrane having a molecular pore size in the range of from about 200 daltons to about 1 kilodaltons to provide a permeate that is an at least partially purified azole heteroaromatic compound-containing mixture and a retentate with at least some impurities.Type: GrantFiled: October 28, 2013Date of Patent: April 12, 2016Assignee: Wincom, Inc.Inventors: Peter F. Vogt, James E. Milawski, Michael E. Lees, Alexander J. Wessel
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Patent number: 9242942Abstract: Impure aryltriazoles such as benzotriazole and tolyltriazole that are contaminated with dark colored imputities can be purified by conversion to an aryltriazole acid salt by treatment with aqueous acid. The aryltriazole acid salt is water soluble whereas the dark colored impurities are not. The aryltriazole acid salt solution is separated from the dark colored impurities and the aryltriazole is recovered by neutralization with base.Type: GrantFiled: July 1, 2013Date of Patent: January 26, 2016Inventor: Randolph K Belter
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Patent number: 9051282Abstract: Disclosed are methods of synthesizing triazoles that avoids the use of concentrated acids in favor of carbonic acid generated from CO2 that can be practiced at ambient and/or elevated temperature and/or atmospheric and/or elevated pressures. The disclosed methods also provide a way of synthesizing triazole products that are sufficiently pure and/or of sufficient concentration whereby the reaction product(s) may not require purification or other treatment before being used in, for example, formulating water treatment compositions that will tend to suppress corrosion or as an intermediate product in a more complex synthesis.Type: GrantFiled: December 17, 2012Date of Patent: June 9, 2015Assignee: CHEMTREAT, INC.Inventors: William H. Henderson, John Richardson
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Publication number: 20150119578Abstract: A process for removing impurities from a liquid azole heteroaromatic compound-containing (e.g., triazole-containing) mixture by: (a) providing a liquid azole heteroaromatic compound-containing mixture having impurities; and (b) passing the azole heteroaromatic compound-containing mixture through at least one filtration membrane which is a nanofiltration membrane and/or ultrafiltration membrane having a molecular pore size in the range of from about 200 daltons to about 1 kilodaltons to provide a permeate that is an at least partially purified azole heteroaromatic compound-containing mixture and a retentate with at least some impurities.Type: ApplicationFiled: October 28, 2013Publication date: April 30, 2015Applicant: Wincom, Inc.Inventors: Peter F. Vogt, James E. Milawski, Michael E. Lees, Alexander J. Wessel
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Publication number: 20150118104Abstract: Compounds and compositions are used as corrosion inhibitors for pipelines for crude oil containing water with high salt concentrations. The inhibitors are ionic liquids, imidazoles, benzotriazoles, and mixtures thereof. The composition includes two or more members of the inhibitors with a solvent. The inhibitors reduce corrosion of metallic surfaces of the pipelines containing crude oil having 0.2 and 40 wt % water, 10,000 to 70,000 ppm salt, and 9 to 600 ppm hydrogen sulfide. A synergic effect is provided by two or more different inhibitors. This synergy is derived from interactions with the metallic surface, among themselves or with the corrosive medium depending on the chain length, to inhibit the corrosion with decrease of the formulation dose. The composition can be a ternary formulation of the three families or two components of one family and a third component of a different family.Type: ApplicationFiled: October 28, 2014Publication date: April 30, 2015Inventors: Jesus MARIN CRUZ, Araceli VEGA PAZ, Luisa Elena MONTIEL SANCHEZ, Salvador CASTILLO CERVANTES, Rafael MARTINEZ PALOU, Arquimedes ESTRADA MARTINEZ, Luis Manuel QUEJ AKE, Jose Luis Rodolfo BENITEZ AGUILAR, Veronica SANCHEZ GARCIA
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Publication number: 20150005508Abstract: Impure aryltriazoles such as benzotriazole and tolyltriazole that are contaminated with dark colored imputities can be purified by conversion to an aryltriazole acid salt by treatment with aqueous acid. The aryltriazole acid salt is water soluble whereas the dark colored impurities are not. The aryltriazole acid salt solution is separated from the dark colored impurities and the aryltriazole is recovered by neutralization with base.Type: ApplicationFiled: July 1, 2013Publication date: January 1, 2015Inventor: Randolph Kenneth Belter
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Patent number: 8912188Abstract: Disclosed herein are substituted quinoxaline carboxylic acids of Formula (I): and compositions thereof, which may be useful as inhibitors of PAS Kinase (PASK) activity in a human or animal for the treatment of diseases such as diabetes mellitus.Type: GrantFiled: March 2, 2012Date of Patent: December 16, 2014Assignee: BioEnergenix, LLCInventors: John M. McCall, Donna L. Romero, Robert C. Kelly
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Publication number: 20140364594Abstract: The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.Type: ApplicationFiled: July 23, 2014Publication date: December 11, 2014Inventors: Takamitsu HOSOYA, Isao KII, Suguru YOSHIDA, Takeshi MATSUSHITA
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Patent number: 8901312Abstract: The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.Type: GrantFiled: March 9, 2011Date of Patent: December 2, 2014Assignee: JNC CorporationInventors: Takamitsu Hosoya, Isao Kii, Suguru Yoshida, Takeshi Matsushita
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Patent number: 8883829Abstract: The present invention relates to novel benzotriazoles and to novel topical compositions comprising these benzotriazoles. Furthermore, the invention relates to the use of the novel benzotriazoles as photostabilizer and solubilizer for dibenzoylmethane derivatives such as Butyl Methoxydibenzoylmethane. In one aspect the invention relates to novel benzotriazoles of formula (Ia) wherein R2 is hydrogen; C1-30alkyl; C1-5alkoxy; C1-5alkoxycarbonyl; C5-7cycloalkyl; C6-10aryl or aralkyl; R3 is hydrogen; C1-5alkyl; C1-5alkoxy or halogen, preferably hydrogen or Cl; R4 is hydrogen or C1-5alkyl; R5 is C1-30alkyl or C5-10cycloalkyl.Type: GrantFiled: January 13, 2011Date of Patent: November 11, 2014Assignee: DSM IP Assets B.V.Inventors: Alexander Schlifke-Poschalko, Christine Mendrok-Edinger, Horst Westenfelder
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Patent number: 8865731Abstract: Provided are: an agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), which comprises a compound having adenosine A2A receptor antagonistic activity or a pharmaceutically acceptable salt thereof as an active ingredient; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance or constipation; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance; and the like.Type: GrantFiled: May 29, 2009Date of Patent: October 21, 2014Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Jun Ouchi, Shunji Kunori, Yozo Kojima, Katsumi Shinoda, Katsutoshi Sasaki, Shiro Shirakura
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Publication number: 20140231715Abstract: The present invention relates to a compound of the formula (I), to the use of this compound in an electronic device, and to an electronic device comprising one or more compounds of the formula (I). The invention furthermore relates to the preparation of the compound of the formula (I) and to a formulation comprising one or more compounds of the formula (I).Type: ApplicationFiled: March 23, 2012Publication date: August 21, 2014Applicant: Merck Patent GmbH Patents & Scientific InformationInventors: Philipp Stoessel, Arne Buesing, Frank Voges, Christof Pflumm, Amir Hossain Parham, Thomas Eberle, Teresa Mujica-Fernaud
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Patent number: 8802053Abstract: Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same are provided. [N-radio-methyl] vorozole substantially separated from an N-3 radio-methyl isomer of vorozole is provided. Separation is accomplished through use of chromatography resins providing multiple mechanisms of selectivity.Type: GrantFiled: March 19, 2013Date of Patent: August 12, 2014Assignee: Brookhaven Science Associates, LLCInventors: Sung Won Kim, Anat Biegon, Joanna S. Fowler
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Patent number: 8795629Abstract: Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same are provided. [N-radio-methyl] vorozole substantially separated from an N-3 radio-methyl isomer of vorozole is provided. Separation is accomplished through use of chromatography resins providing multiple mechanisms of selectivity.Type: GrantFiled: February 11, 2010Date of Patent: August 5, 2014Assignee: Brookhaven Science Associates, LLCInventors: Sung Won Kim, Anat Biegon, Joanna S. Fowler
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Patent number: 8785482Abstract: The present invention is directed to cyclohexene benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.Type: GrantFiled: April 30, 2012Date of Patent: July 22, 2014Assignee: Merck Sharp & Dohme Corp.Inventors: Douglas C. Beshore, Scott D. Kuduk
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Patent number: 8772276Abstract: The present invention is directed to alkyne benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.Type: GrantFiled: April 30, 2012Date of Patent: July 8, 2014Assignee: Merck Sharp & Dohme Corp.Inventors: Scott D. Kuduk, Jason W. Skudlarek
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Publication number: 20140171658Abstract: Disclosed are methods of synthesizing triazoles that avoids the use of concentrated acids in favor of carbonic acid generated from CO2 that can be practiced at ambient and/or elevated temperature and/or atmospheric and/or elevated pressures. The disclosed methods also provide a way of synthesizing triazole products that are sufficiently pure and/or of sufficient concentration whereby the reaction product(s) may not require purification or other treatment before being used in, for example, formulating water treatment compositions that will tend to suppress corrosion or as an intermediate product in a more complex synthesis.Type: ApplicationFiled: December 17, 2012Publication date: June 19, 2014Applicant: ChemTreat Inc.Inventors: William H. Henderson, John Richardson
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Publication number: 20140088150Abstract: The present invention is directed to cyclohexene benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.Type: ApplicationFiled: April 30, 2012Publication date: March 27, 2014Inventors: Douglas C. Beshore, Scott D. Kuduk
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Publication number: 20140088112Abstract: The present invention is directed to alkyne benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.Type: ApplicationFiled: April 30, 2012Publication date: March 27, 2014Inventors: Scott D. Kuduk, Jason W. Skudlarek
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Patent number: 8614229Abstract: The present invention relates to Substituted Indole Derivatives, compositions comprising at least one Substituted Indole Derivative, and methods of using these Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.Type: GrantFiled: August 27, 2008Date of Patent: December 24, 2013Assignee: Merck Sharp & Dohme Corp.Inventors: Gopinadhan N. Anilkumar, Frank Bennett, Tin-Yau Chan, Kevin X. Chen, Mousumi Sannigrahi, Francisco Velazquez, Srikanth Venkatraman, Qingbei Zeng, Jose S. Duca, Charles A. Lesburg, Joseph A. Kozlowski, F. George Njoroge, Stuart B. Rosenblum, Neng-Yang Shih
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Patent number: 8598078Abstract: Compounds of Formula I wherein the substituents are as defined in Claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as agrochemical active ingredients and can be prepared in a manner known per se.Type: GrantFiled: August 21, 2008Date of Patent: December 3, 2013Assignee: Syngenta Crop Protection, LLCInventors: Olivier Loiseleur, Roger Graham Hall, André Denis Stoller, Gerald Wayne Craig, André Jeanguenat, Andrew Edmunds
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Patent number: 8585938Abstract: UV absorbing compounds that are effective in blocking UV and short-wavelength blue light are disclosed. The UV absorbing compounds are particularly suitable for use in intraocular lens materials.Type: GrantFiled: March 29, 2013Date of Patent: November 19, 2013Assignee: Novartis AGInventors: David L. Jinkerson, Walter R. Laredo
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Publication number: 20130225831Abstract: Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same are provided. [N-radio-methyl] vorozole substantially separated from an N-3 radio-methyl isomer of vorozole is provided. Separation is accomplished through use of chromatography resins providing multiple mechanisms of selectivity.Type: ApplicationFiled: March 19, 2013Publication date: August 29, 2013Applicant: Brookhaven Science Associates, LLCInventor: Brookhaven Science Associates, LLC
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Patent number: 8519074Abstract: Polymers including pendent hydrophobic groups and pendent proton transfer groups are shown to form nanostructured films exhibiting greatly increased proton conductivity compared with films prepared from corresponding polymers lacking hydrophobic groups. The polymers can include repeating units each of which has both a hydrophobic group and a proton transfer group. Alternatively, the polymers can be the product of copolymerizing a first monomer with at least one hydrophobic group and a second monomer with at least one proton transfer group. The polymers are useful for the preparation of fuel cell proton exchange membranes.Type: GrantFiled: December 21, 2010Date of Patent: August 27, 2013Assignee: The University of MassachusettesInventors: Sankaran Thayumanavan, Mark Tuominen, Ryan Hayward
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Patent number: 8425891Abstract: Dihydroxybenzotriazole UV absorbing compounds that are particularly useful in ophthalmic devices are disclosed.Type: GrantFiled: October 15, 2012Date of Patent: April 23, 2013Assignee: Novartis AGInventor: David L. Jinkerson
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Patent number: 8415131Abstract: Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.Type: GrantFiled: October 23, 2009Date of Patent: April 9, 2013Assignee: University of South CarolinaInventors: Qian Wang, Kai Li, Charlene Mello
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Publication number: 20130074927Abstract: The invention provides highly fluorescent materials comprising a single (n=0) or a series (n=1, 2, etc.) of benzo heterocyclic systems. The photo-stable highly luminescent chromophores are useful in various applications, including in wavelength conversion films. Wavelength conversion films have the potential to significantly enhance the solar harvesting efficiency of photovoltaic or solar cell devices.Type: ApplicationFiled: September 25, 2012Publication date: March 28, 2013Applicant: NITTO DENKO CORPORATIONInventor: NITTO DENKO CORPORATION
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Publication number: 20130029846Abstract: The present invention relates to the use of bicyclic amidine compounds of formula I as defined in the description, and the N-oxides, and salts thereof for combating harmful fungi, and also to compositions and seed comprising at least one such compound. The invention also relates to novel bicyclic amidines and processes and intermediates for preparing these compounds.Type: ApplicationFiled: March 28, 2011Publication date: January 31, 2013Applicant: BASF SEInventors: Joachim Rheinheimer, Christian Pilger, Stefan Redlich, Doris Kremzow, Claudia Rosenbaum, Burghard Liebmann, Wassilios Grammenos
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Publication number: 20130011901Abstract: The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.Type: ApplicationFiled: March 9, 2011Publication date: January 10, 2013Applicant: JNC CORPORATIONInventors: Takamitsu Hosoya, Isao Kii, Suguru Yoshida, Takeshi Matsushita
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Patent number: 8324400Abstract: This invention is about a material which provides to observe all colors necessary for display technologies in a very small potential range. The material is a derivative of benzotriazole containing donor acceptor type conducting polymer which is soluble, fluorescent and can be used in LEDs, solar cells, electrochromic devices, smart windows and many other technologies.Type: GrantFiled: December 14, 2011Date of Patent: December 4, 2012Inventors: Levent Kamil Toppare, Abidin Balan, Derya Baran
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Patent number: 8324256Abstract: Described herein are tri-functional compounds useful in the production of ophthalmic lenses. The compounds are composed of UV absorber having a polymerization initiator directly or indirectly bonded to the ultraviolet absorber, and an olefinic group directly or indirectly bonded to the ultraviolet absorber. Also described herein are polymers and ophthalmic lenses produced from the tri-functional compounds described herein.Type: GrantFiled: December 17, 2009Date of Patent: December 4, 2012Assignee: Novartis AGInventors: Angelika Maria Domschke, Lynn Cook Winterton, Troy Vernon Holland, Richard Charles Turek
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Patent number: 8323631Abstract: Dihydroxybenzotriazole UV absorbing compounds that are particularly useful in ophthalmic devices are disclosed.Type: GrantFiled: July 19, 2011Date of Patent: December 4, 2012Assignee: Novartis AGInventor: David L. Jinkerson
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Patent number: 8314131Abstract: The present invention comprises a new class of compounds useful for modulating the activity of p38 MAP kinase. The compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R1 and R5 are defined herein. The invention further provides pharmaceutical compositions including one or more compounds of Formula I, use of such compounds and compositions for treatment of p38 MAP kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.Type: GrantFiled: September 19, 2008Date of Patent: November 20, 2012Assignee: Amgen Inc.Inventors: Liping H. Pettus, Kelvin K. C. Sham, Andrew Tasker, Shimin Xu
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Patent number: 8273877Abstract: Substituted tetraazapentalenes have two benzenoid rings and eight substitutable positions. Substitutions are made of hydrogen or C—H groups in favor of amino groups, nitro groups or nitrogen atoms. The tetraazapentalenes are synthesized through an intermediate azo, which is made from a 1:1:1 molar ratio of a nitroaniline, sodium nitrite and an amine.Type: GrantFiled: November 18, 2011Date of Patent: September 25, 2012Assignee: The United States of America as Represented by the Secretary of the NavyInventors: Alfred G. Stern, Patrick A. Caruana
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Patent number: 8262947Abstract: Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials.Type: GrantFiled: July 2, 2010Date of Patent: September 11, 2012Assignee: Novartis AGInventor: Walter R. Laredo
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Patent number: 8262949Abstract: The instant invention relates to novel benzotriazole UV-absorbers having a long wavelength shifted absorption spectrum with significant absorbance up to 410-420 nm. Further aspects of the invention are a process for their preparation, a UV stabilized composition containing the new UV-absorbers and the use of the new compounds as UV-light stabilizers for organic materials.Type: GrantFiled: June 18, 2007Date of Patent: September 11, 2012Assignee: BASF SEInventors: Katharina Fritzsche, Markus Grob, Adalbert Braig, Ilona Marion Kienzle, Gérard Daniel Georges Vilain
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Patent number: 8262948Abstract: Disclosed are ophthalmic device materials having improved light transmission characteristics. The materials contain a combination of certain UV absorbers and blue-light absorbing chromophores.Type: GrantFiled: April 27, 2011Date of Patent: September 11, 2012Assignee: Novartis AGInventors: Walter R. Laredo, Ali E. Akinay
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Patent number: 8232326Abstract: Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials.Type: GrantFiled: February 8, 2012Date of Patent: July 31, 2012Assignee: Novartis AGInventor: Walter R. Laredo
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Publication number: 20120172392Abstract: Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.Type: ApplicationFiled: March 7, 2012Publication date: July 5, 2012Inventors: LUISA M. SALTER-CID, ERIC Y. WANG, MARY T. MACDONALD, JINGJING ZHAO
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Patent number: 8153703Abstract: Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials.Type: GrantFiled: November 3, 2009Date of Patent: April 10, 2012Assignee: Novartis AGInventor: Walter R. Laredo
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Patent number: 8043607Abstract: Dihydroxybenzotriazole UV absorbing compounds that are particularly useful in ophthalmic devices are disclosed.Type: GrantFiled: July 10, 2009Date of Patent: October 25, 2011Assignee: Novartis AGInventor: David L. Jinkerson
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Patent number: 8026360Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: August 13, 2009Date of Patent: September 27, 2011Assignee: Xenon Pharmaceuticals Inc.Inventors: Rajender Kamboj, Zaihui Zhang, Jianmin Fu, Vandna Raina, Serguei Sviridov, Vishnumurthy Kodumuru, Nagasree Chakka, Shifeng Lui, Shaoyi Sun, Duanjie Hou
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Patent number: 7956185Abstract: Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.Type: GrantFiled: May 24, 2007Date of Patent: June 7, 2011Assignee: Abbott LaboratoriesInventors: Robert B. Diebold, Stevan W. Djuric, Vincent L. Giranda, Laura A. Hexamer, Nan-Horng Lin, Julie M. Miyashiro, Thomas D. Penning, Magdalena Przytulinska, Thomas J. Sowin, Gerard M. Sullivan, Zhi-Fu Tao, Yunsong Tong, Anil Vasudevan, Le Wang, Keith W. Woods, Zhiren Xia, Henry Q. Zhang
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Publication number: 20110118219Abstract: Prodrugs of steroidal C-17 benzoazoles, pyrimidinoazoles(azabenzoazoles) and diazines. Methods of synthesis are also described, whereby a prodrug group is substituted for a functional group at A ring portion of the ABC ring structure of the steroid. Suitable prodrug groups include amino acid groups, succinate groups, phosphate groups, or sulfamate groups. The prodrugs of the disclosed compounds allow for improved oral bioavailability of the compounds that are inhibitors of human CYP17 enzyme as well as potent antagonists of both wild type and mutant androgen receptors (AR). The compounds and the corresponding prodrugs are useful for the treatment of conditions such as human prostate cancer, breast cancer, and prostate hyperplasia.Type: ApplicationFiled: March 19, 2009Publication date: May 19, 2011Applicant: UNIVERSITY OF MARYLAND, BALTIMOREInventors: Vincent C.O. Njar, Angela M.H. Brodie, Lalji K. Gediya