Polycyclo Ring System Having The Triazole Ring As One Of The Cyclos Patents (Class 548/262.4)
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Patent number: 7205406Abstract: An azomethine dye represented by the following Formula 1: wherein Y represents a substituent of 0.2??p?0.9, Z1 and Z2 each represent —CR1?, where R1 represents a hydrogen atom or a substituent, or —N?, L represents the group represented by the following Formula 1a, X represents an unsubstituted or substituted di-alkylamino group, R represents an unsubstituted or substituted alkyl group, and n represents an integer more than 0. wherein B represents a group of non-metallic atoms which are necessary to form a heterocyclic ring.Type: GrantFiled: July 1, 2005Date of Patent: April 17, 2007Assignee: Konica Minolta Holdings, Inc.Inventors: Emiko Kataoka, Takatugu Suzuki, Dai Ikemizu
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Patent number: 7179911Abstract: Processes for using a compound of formula III: to make compounds of formulae I and II: and processes for making the compound of formula III, where R1-5 and J are as defined herein.Type: GrantFiled: June 7, 2005Date of Patent: February 20, 2007Assignee: WyethInventors: Ting-Zhong Wang, Lalitha Krishnan, Joseph Zeldis, Jeremy I. Levin, Jean Schmid, Mellard Jennings, Huan-Qiu Li, Zhixin Wen
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Patent number: 7153873Abstract: Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula: addition products thereof with acids, and methods for preparing the salts and addition products. Also disclosed are pharmaceutical compositions comprising the same and methods using the pharmaceutical compositions for the treatment or prophylaxis of pain, drug or alcohol abuse, diarrhoea, gastritis, ulcers, urinary incontinence, depression, narcolepsy, overweight, asthma, glaucoma, tinnitus, itching, hyperkinetic syndrome, epilepsy, or schizophrenia, for inducing anesthesia, and for anxiolysis.Type: GrantFiled: June 6, 2006Date of Patent: December 26, 2006Assignee: Gruenenthal GmbHInventors: Matthias Gerlach, Corinna Sundermann
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Patent number: 7041833Abstract: A process and intermediate useful for forming a 1H-Pyrazolo[1,5-b][1,2,4]triazole compounds comprise the step of reacting a 1,5-diaminopyrazole bearing a substituent, bonded to one and only one of the amine nitrogens by an acyl or thioacyl group, with a dehydrating agent in the presence of an aprotic solvent.Type: GrantFiled: April 23, 2004Date of Patent: May 9, 2006Assignee: Eastman Kodak CompanyInventor: Catherine Mineur
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Patent number: 7004979Abstract: The invention relates to a dye composition comprising an oxidation base of the diaminopyrazole type and a pyrazolo-azole coupler. The invention also relates to the use of this composition for dyeing keratin fibres and also to the dyeing process using this composition.Type: GrantFiled: September 27, 2002Date of Patent: February 28, 2006Assignee: L'Oreal S.A.Inventors: Sylvain Kravtchenko, Alain Lagrange
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Patent number: 6995273Abstract: A compound represented by the following formula (I): and a silver halide color photographic light-sensitive material containing the compound as a coupler. In formula (I), R represents an alkyl, alkenyl, alkynyl, aryl or heterocyclic group; L is —CO— or —SO2—; and X is a hydrogen atom or a group capable of being split-off upon coupling with an oxidized product of a developing agent selected from the group consisting of a halogen atom, an aryloxy group, an alkoxy group, an arylthio group, an alkylthio group, an acyloxy group, a sulfonamide group, and an acylamino group whose bonding site is the nitrogen atom.Type: GrantFiled: December 11, 2002Date of Patent: February 7, 2006Assignee: Fuji Photo Film Co., Ltd.Inventors: Hideaki Satoh, Takeshi Nakamine, Nobuo Seto, Hiroyuki Yoneyama, Yasuhiro Shimada
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Patent number: 6946562Abstract: Disclosed is a process for the preparation of a peptoid substituted azole compound comprising reacting an amino functionalized azole compound with a resin bound peptoid oligomer bearing a terminal halogen substituent followed by cleavage of the resultant product from the resin surface using a fluorinated organic acid in an inert solvent.Type: GrantFiled: December 12, 2001Date of Patent: September 20, 2005Assignee: Eastman Kodak CompanyInventors: Donald R. Diehl, Robert J. Niger, Hans F. Schmitthenner, William J. Sonnefeld, Richard P. Dunlap
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Patent number: 6936631Abstract: A novel bicyclic imidazo-5-yl-amine derivative of Formula I, wherein X denotes CR5, N or S, and Y in the case where X denotes S, denotes CR6 or N and in all other cases denotes N, and methods for preparation thereof are disclosed. Also disclosed are methods for treating pain using the compound of Formula I, and pharmaceutical compositions comprising the compound of Formula I.Type: GrantFiled: August 5, 2003Date of Patent: August 30, 2005Assignee: Gruenenthal GmbHInventors: Matthias Gerlach, Corinna Maul
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Patent number: 6888004Abstract: The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) useful for the treatment of depression, anxiety, affective disorders, feeding disorders, post-traumatic stress disorder, headache, drug addiction, inflammatory disorders, drug or alcohol withdrawal symptoms and other conditions the treatment of which can be effected by the antagonism of the CRF-1 receptor.Type: GrantFiled: January 11, 2002Date of Patent: May 3, 2005Assignee: Bristol-Myers Squibb CompanyInventors: Gene M. Dubowchik, Vivekananda M. Vrudhula, Dmitry Zuev, Bireshwar Dasgupta, John E. Macor
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Patent number: 6855827Abstract: A composition for dyeing keratinous fibers, in particular human keratinous fibers, such as human hair, containing, in a medium suitable for dyeing: as oxidation base, at least one compound of formula (I) below: in which: R1 is a hydrogen atom, an alkyl radical, an aryl radical, a heterocycle radical, or a halogen atom, R2 is a hydrogen atom, an alkyl radical, a hydroxyalkyl radical, or an aminoalkyl radical, Za, Zb and Zc are independently a nitrogen atom or a carbon carrying an R3 or R4 radical with meanings identical to those of R1; wherein at least one of Za, Zb and Zc is a nitrogen atom; it being possible for R3 and R4 to form between themselves a substituted or unsubstituted aromatic ring.Type: GrantFiled: March 7, 2002Date of Patent: February 15, 2005Assignee: L'OréalInventors: Laurent Vidal, Mireille Maubru
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Patent number: 6787294Abstract: Disclosed is a photographic element comprising a light sensitive silver halide emulsion layer and, having associated with that layer, a 1H-pyrazo[1,5-b]-1,2,4-triazole dye forming coupler having a fully substituted carbon atom at the 6-position, a chloro group at the 7-position, and, at the 2-position, a propionic ester moiety.Type: GrantFiled: June 24, 2003Date of Patent: September 7, 2004Assignee: Eastman Kodak CompanyInventors: Robert F. Romanet, Susan M. Fischer, David G. Lincoln, Gary M. Russo
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Dye-forming coupler, silver halide photographic light-sensitive material and azomethine dye compound
Publication number: 20040122238Abstract: A dye-forming coupler and compound of formula (I): formula (I) 1Type: ApplicationFiled: October 7, 2003Publication date: June 24, 2004Applicant: Fuji Photo Film Co., Ltd.Inventors: Kiyoshi Takeuchi, Shigeki Uehira, Mario Aoki, Jun Ogasawara, Yasuhiro Shimada, Seiji Ichijima, Yasuaki Deguchi, Naoto Matsuda, Akira Ikeda, Hisashi Mikoshiba, Masaharu Sugai, Taiji Katsumata -
Publication number: 20040110962Abstract: Disclosed is a process for forming a 1H-pyrazolo (1,5-b)-[1,2,4]-triazole compound by ring closing a pyrazoloamidine compound comprising reacting the amidine with an oxidizing agent having a reduction potential vs Ag/AgCl that is more positive than −0.16V and less than +1.43V in the presence of a halogen atom. The invention also discloses certain triazole compounds that are successfully made by the conventional process. The process and compounds of the invention provide improved yields and reduce or eliminate unwanted side-reactions.Type: ApplicationFiled: November 6, 2003Publication date: June 10, 2004Inventors: Ileana Place, John W. Harder, Robert F. Romanet, William B. Vreeland
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Publication number: 20040039197Abstract: The invention relates to novel, substituted, fused indole and heteroindole derivatives of the general formula I 1Type: ApplicationFiled: August 30, 2002Publication date: February 26, 2004Inventors: Heinz Weinberger, Thomas Beckers, Mathias Schmidt, Silke Baasner, Bernd Nickel
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Patent number: 6673825Abstract: Urazole compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective as anti-inflammatory or immunosuppressive agents, wherein L and K are O or S; Q is a linker such as —O—, —S—, C(═O), and so forth, R1 is an aryl or heteroaryl group, and R3, R4a, R4c, Z, r, s and t are as defined in the specification.Type: GrantFiled: May 21, 2002Date of Patent: January 6, 2004Assignees: Bristol-Myers Squibb Co., Cerep SAInventors: Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Antoine Nicolai, Edwin J. Iwanowicz, T. G. Murali Dhar
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Patent number: 6667330Abstract: Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial infarction, myocardial ischemia, chronic heart failure, inflammation and other oxidative stress-related conditions, as well as Alzheimer's disease and senile dementia; they are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.Type: GrantFiled: January 28, 2003Date of Patent: December 23, 2003Assignee: Galileo Pharmaceuticals, Inc.Inventors: Bing Wang, Wei Zhang, Jiangao Song, Ughetta del Balzo, Lesley Brown, Gail Walkinshaw
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Patent number: 6657066Abstract: Disclosed is a process for forming a 1H-pyrazolo (1,5-b)-[1,2,4]-triazole compound by ring closing a pyrazoloamidine compound comprising reacting the amidine with an oxidizing agent having a reduction potential vs Ag/AgCl that is more positive than −0.16V and less than +1.43V in the presence of a halogen atom. The invention also discloses certain triazole compounds that are successfully made by the conventional process. The process and compounds of the invention provide improved yields and reduce or eliminate unwanted side-reactions.Type: GrantFiled: December 10, 2002Date of Patent: December 2, 2003Assignee: Eastman Kodak CompanyInventors: Ileana Place, John W. Harder, Robert F. Romanet, William B. Vreeland
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Patent number: 6649771Abstract: A pyrrolotriazole compound of the following formula (I), and a silver halide color photographic light-sensitive material containing the pyrrolotriazole compound as a cyan coupler: wherein R1 and R2 each independently are an alkyl, cycloalkyl, alkenyl, aryl or heterocyclic group, provided that R1 and R2 may bond together to form a 5- or 6-membered nitrogen-containing heterocycle; R3 is an alkyl, cycloalkyl, alkenyl, aryl or heterocyclic group; R4 is an alkyl, cycloalkyl, alkenyl, alkoxy or amino group; R5 is a hydrogen atom, an alkyl or aryl group; R6 is an alkyl, cycloalkyl or alkenyl group; and X is an oxygen or sulfur atom.Type: GrantFiled: March 26, 2001Date of Patent: November 18, 2003Assignee: Fuji Photo Film Co., Ltd.Inventors: Takeshi Nakamine, Nobuo Seto, Hideaki Sato, Yasuaki Deguchi
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Publication number: 20030203327Abstract: A silver halide color photosensitive material comprises at least one layer on a support.Type: ApplicationFiled: January 28, 2003Publication date: October 30, 2003Applicant: FUJI PHOTO FILM CO.,LTD.Inventors: Yasuhiro Kato, Hisashi Mikoshiba, Naoto Matsuda
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Patent number: 6635634Abstract: This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic, anti-urinary incontinence and anti-pollakiuria activities, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.Type: GrantFiled: February 14, 2002Date of Patent: October 21, 2003Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Minoru Sakurai, Naoaki Fujii, Kumi Hosoi, Yasuyo Tomishima, Hisashi Takasugi, Hajime Sogabe, Hirofumi Ishikawa, Naomi Hanioka
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Patent number: 6586552Abstract: Aminoazole-blocked isocyanate components can be used as self crosslinking binders in heat-curable compositions.Type: GrantFiled: April 9, 2001Date of Patent: July 1, 2003Assignee: E. I. du Pont de Nemours and CompanyInventors: Carmen Flosbach, Patrick Gloeckner, Michael Herm, Helmut Ritter
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Publication number: 20030055094Abstract: The invention provides compounds of the formula I 1Type: ApplicationFiled: July 31, 2002Publication date: March 20, 2003Inventors: Chongqing Sun, Jeffrey A. Robl, Mark E. Salvati, Tammy Wang, Lawrence Hamann, David Augeri
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Publication number: 20030013745Abstract: Urazole compounds having the formula (I), 1Type: ApplicationFiled: May 21, 2002Publication date: January 16, 2003Inventors: Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Antoine Nicolai, Edwin J. Iwanowicz, T. G. Murali Dhar
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Patent number: 6495697Abstract: A silver halide color photographic lightsensitive material contains a coupler represented by formula (I) below in at least one layer on a support (in this formula, X represents a hydrogen atom or a group which can split off by a coupling reaction with an oxidized form of an aromatic primary amine color developing agent, each of R1 and R2 represents an electron-attracting group having a Hammett's substituent constant p value of 0.20 or more, and the sum of the p values of R1 and R2 is 0.65 or more, and each of G1 and G2 represents a nitrogen atom or a substituent). A pyrrolotriazole compound represented by formula (I) below is also provided.Type: GrantFiled: April 15, 2002Date of Patent: December 17, 2002Assignee: Fuji Photo Film Co., Ltd.Inventors: Keiichi Tateishi, Hisashi Mikoshiba, Naoto Matsuda
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Patent number: 6495546Abstract: Propanolamine derivatives represented by the following formula (I): These derivatives may be &bgr;3 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria activities. Pharmaceutical compositions containing such propanolamine derivatives, methods for the prevention and/or treatment diseases using these propanolamine derivatives, and processes for their preparation are also described.Type: GrantFiled: November 22, 2000Date of Patent: December 17, 2002Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Minoru Sakurai, Naoaki Fujii, Kumi Hosoi, Yasuyo Tomishima, Hisashi Takasugi, Hajime Sogabe, Hirofumi Ishikawa, Naomi Hanioka
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Publication number: 20020183320Abstract: A novel bicyclic imidazo-5-yl-amine derivative of Formula I, 1Type: ApplicationFiled: April 8, 2002Publication date: December 5, 2002Inventors: Matthias Gerlach, Corinna Maul
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Patent number: 6465657Abstract: There is disclosed a method of preparing a refined organic compound, comprising the steps of adding water to an organic reaction mixture and mixing them, and then subjecting the mixture to filtration processing using a filter, to separate an organic phase from an aqueous phase, and then isolating the intended organic compound from said organic phase. The method enables highly precise removal of a water-easily soluble compound from an organic reaction mixture, and it further enables obtaining the intended synthesized organic compound in high yield with a high quality.Type: GrantFiled: March 30, 2000Date of Patent: October 15, 2002Assignee: Fuji Photo Film Co., Ltd.Inventors: Masayuki Goto, Noboru Tanaka
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Publication number: 20020128488Abstract: An azomethine compound is represented by the formula (I).Type: ApplicationFiled: March 13, 2002Publication date: September 12, 2002Applicant: FUJI PHOTO FILM CO., LTD.Inventors: Katsuyoshi Yamakawa, Masuji Motoki, Naoki Asanuma, Ryo Suzuki, Tadahisa Sato, Hisashi Mikoshiba
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Publication number: 20020115029Abstract: A silver halide color photographic lightsensitive material comprising at least one layer on a support, wherein the at least one layer contains a coupler represented by formula (I) below 1Type: ApplicationFiled: November 21, 2001Publication date: August 22, 2002Inventors: Yasuhiro Kato, Hisashi Mikoshiba, Naoto Matsuda, Tetsuro Kojima
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Publication number: 20020107399Abstract: There is disclosed a 1H-pyrrolo-[1,2-b] [1,2,4]triazole compound represented by formula (I): 1Type: ApplicationFiled: February 4, 2002Publication date: August 8, 2002Applicant: Fuji Photo Film Co., Ltd.Inventors: Yasuhiro Shimada, Hideki Maeta, Yoshio Shimura
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Publication number: 20020065341Abstract: Benzotriazole UV absorbers which are substituted at the 5-position of the benzo ring by an electron withdrawing group exhibit enhanced durability and very low loss rates when incorporated into automotive coatings. This is particularly the case when the 3-position of the phenyl ring is also substituted by phenyl or phenylalkyl such as &agr;-cumyl. Compounds where the 5-position of the benzo ring are substituted by perfluoroalkyl such as trifluoromethyl are particularly of interest for both their enhanced durability and for their excellent solubility and excellent color properties in some thermoplastic compositions when the phenyl ring is substituted at the 3-position by hydrogen or tert-alkyl.Type: ApplicationFiled: May 7, 2001Publication date: May 30, 2002Inventors: Ramanathan Ravichandran, Joseph Suhadolnik, Mervin G. Wood, Anthony Debellis, Robert E. Detlefsen, Revathi Iyengar, Jean-Pierre Wolf
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Patent number: 6384219Abstract: There is disclosed a 1H-pyrrolo-[1,2-b][1,2,4]triazole compound represented by formula (I): wherein R is an alkyl group; R1, R2, R3, R1′, R2′, and R3′ each are a hydrogen atom or an alkyl group; R1 and R2, and R1′ and R2′ may bond together to form a ring, respectively; R4 is a hydrogen atom or an alkyl group, and X is heterocyclic group, a substituted amino group, or an aryl group. The compound is useful as a photographic cyan coupler. There is also disclosed synthetic intermediates of the compound and a production method of the intermediates.Type: GrantFiled: January 7, 1998Date of Patent: May 7, 2002Assignee: Fuji Photo Film Co., Ltd.Inventors: Yasuhiro Shimada, Hideki Maeta, Yoshio Shimura
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Publication number: 20020022731Abstract: A description is given of a process for the transesterification of carboxylic esters, characterized in that the catalyst used is a tin(IV) compound comprising a radical of the formula 1Type: ApplicationFiled: March 29, 2001Publication date: February 21, 2002Inventors: Benoit Pugin, Benoit Dubuis, Adrian Muller
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Publication number: 20020018973Abstract: A coupler represented by the following formula (I), and a silver halide color photographic light-sensitive material containing the coupler: 1Type: ApplicationFiled: June 11, 2001Publication date: February 14, 2002Applicant: FUJI PHOTO FILM CO., LTD.Inventors: Hideaki Satoh, Takeshi Nakamine, Nobuo Seto, Hiroyuki Yoneyama, Yasuhiro Shimada
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Patent number: 6303625Abstract: The invention is directed to novel triazolopyridine derivatives which are useful as antagonists of GPIIb/IIIa. Pharmaceutical compositions comprising the triazolopyridine derivatives of the present invention, methods of treating conditions mediated by GPIIb/IIIa (e.g., methods for treating platelet-mediated thrombotic disorders) along with processes for making the compounds and novel intermediates are also disclosed.Type: GrantFiled: July 15, 1999Date of Patent: October 16, 2001Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: William J. Hoekstra, Edward C. Lawson, Bruce E. Maryanoff
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Patent number: 6258751Abstract: The present invention relates to novel heterocyclic compounds and their agronomically suitable salts, methods for the use of these compounds in controlling unwanted plant species, and the use of herbicidal compositions containing these compounds. In particular, the present invention pertains to substituted and unsubstituted triazoles, imidazoles and pyrazoles linked to a heterocyclic substituted benzene group. Such compounds are useful as pre-emergent and post-emergent herbicides.Type: GrantFiled: June 13, 2000Date of Patent: July 10, 2001Assignee: Rohm and Haas CompanyInventors: Richard Martin Jacobson, Mark Joseph Mulvihill, Changling Liu, Xiaonan Liu
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Patent number: 6242609Abstract: A method for manufacturing a color coupler used in a silver halide photographic light-sensitive material using an ammonium trihalide. Said method for manufacturing the color coupler comprising the following step: a step for halogenating a coupling position of a four equivalent coupler using a halogenating agent, wherein said halogenating agent is said ammonium trihalide.Type: GrantFiled: April 7, 1999Date of Patent: June 5, 2001Assignee: Konica CorporationInventor: Fumio Ishii
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Patent number: RE39263Abstract: There is disclosed substituted thiocarboxamides of the general formula (I) useful as herbicides.Type: GrantFiled: December 12, 2003Date of Patent: September 5, 2006Assignee: Bayer AktiengesellschaftInventors: Karl-Heinz Linker, Kurt Findeisen, Roland Andree, Mark-Wilhelm Drewes, Andreas Lender, Otto Schallner, Wilhelm Haas, Hans-Joachim Santel, Markus Dollinger