Plural Chalcogen Bonded Directly To Ring Carbons Of The Triazole Ring Patents (Class 548/263.4)
  • Patent number: 9024039
    Abstract: This invention relates to the design, synthesis and use of synthetic vitamin D and other steroidal analogs. It further relates to the therapeutic use of such analogs and their manufacture.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: May 5, 2015
    Assignee: Women & Infants' Hospital of Rhode Island
    Inventors: Laurent Brard, Satyan Kalkunte, Rakesh Kumar Singh
  • Publication number: 20140378668
    Abstract: A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an Ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. This reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds.
    Type: Application
    Filed: June 25, 2014
    Publication date: December 25, 2014
    Inventors: Carlos F. Barbas, III, Hitoshi Ban, Julia Gavrilyuk
  • Publication number: 20140206884
    Abstract: The present invention relates to a process using Grignard reagents for providing thio-triazolo group-containing compounds.
    Type: Application
    Filed: March 24, 2014
    Publication date: July 24, 2014
    Applicant: BASF SE
    Inventors: Maximilian DOCHNAHL, Michael KEIL, Joachim GEBHARDT, Uwe Josef VOGELBACHER, Frederik MENGES, Michael RACK, Jens RENNER, Bernd WOLF
  • Publication number: 20140018355
    Abstract: The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF.
    Type: Application
    Filed: June 27, 2013
    Publication date: January 16, 2014
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Timothy L. MACDONALD, Jerry L. NADLER, Peng CUI
  • Publication number: 20130190179
    Abstract: The present invention relates generally to the use of biological or chemical control agents with for controlling insects and nematodes and to methods particularly useful for combating insects or nematodes and/or increasing crop yield in plants that are at least partially resistant to one or more parasitic nematodes or insects.
    Type: Application
    Filed: October 13, 2011
    Publication date: July 25, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Ruediger Hain, Gerhard Johann, Guenter Donn
  • Publication number: 20130116269
    Abstract: The present invention relates to novel cyclic N,N?-diarylureas and N,N?-diarylthioureas—androgen receptor antagonists, anti-cancer agent, pharmaceutical composition, medicament, and method for treatment of cancerous diseases, among them prostate cancer.
    Type: Application
    Filed: July 1, 2011
    Publication date: May 9, 2013
    Inventors: Alexandre Vasilievich Ivachtchenko, Oleg Dmitrievich Mitkin
  • Publication number: 20130005985
    Abstract: The present invention relates to a process using Grignard reagents for providing thio-triazolo group-containing compounds.
    Type: Application
    Filed: March 15, 2011
    Publication date: January 3, 2013
    Applicant: BASF SE
    Inventors: Maximilian Dochnahl, Michael Keil, Joachim Gebhardt, Uwe Josef Vogelbacher, Frederik Menges, Michael Rack, Jens Renner, Bernd Wolf
  • Publication number: 20120289682
    Abstract: A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an Ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. This reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds.
    Type: Application
    Filed: December 23, 2010
    Publication date: November 15, 2012
    Inventors: Carlos F. Barbas, III, Hitoshi Ban, Julia Gavrilyuk
  • Patent number: 8263782
    Abstract: The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein G is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl, indazolyl; p is an integer ranging from 0 to 5; R1 is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl; or corresponds to a group R5; R2 is hydrogen or C1-4alkyl; R3 is C1-4alkyl; R4 is hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; R5 is a moiety selected from the group consisting of: isoxazolyl, —CH2—N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and such a group is optionally substituted by one or two substituent
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: September 11, 2012
    Assignee: Glaxo Group Limited
    Inventors: Luca Arista, Giorgio Bonanomi, Gabriella Gentile, Dieter Hamprecht, Fabrizio Micheli, Anna Maria Capelli, Federica Damiani, Romano Di Fabio, Luca Tarsi, Giovanna Tedesco, Silvia Terreni
  • Publication number: 20120172225
    Abstract: The present invention relates to selective-herbicidal compositions, characterized in that they contain an effective amount of the compound 2-(2-trifluoromethoxy-phenylsulphonylarninocarbonyl)-4-methyl-5-methoxy-2,4-dihydro-3H-1,2,4-triazol-3-one of the formula (I) and/or of salts of the compound of the formula (I), and to the use of these compositions for the selective control of weeds in crops of cereals, in particular crops of wheat, and to methods for the selective control of weeds in crops of cereals by applying the compositions together with surfactants and/or customary extenders.
    Type: Application
    Filed: March 13, 2012
    Publication date: July 5, 2012
    Applicant: Arysta LifeScience North America, LLC
    Inventors: Dieter Feucht, Hans-Joachim Santel, Klaus Lürssen, Ingo Wetcholowsky, Peter Dahmen, Klaus-Helmut Müller
  • Patent number: 7994330
    Abstract: It is desirable to provide a method for easily removing catalyst-derived impurities from a product of a reaction by the catalysis of a compound having a dicarboximide skeleton and thereby efficiently yielding a target compound with high purity. Disclosed is a method for producing an organic compound through a reaction of a substrate in the presence of a catalyst, the catalyst including a compound having a dicarboximide skeleton represented by following Formula (i): wherein R represents hydrogen atom or a hydroxyl-protecting group. The method includes the step of treating a reaction product with hot water so as to decompose and remove an impurity derived from the catalyst. The temperature of the hot water is preferably 100° C. or higher.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: August 9, 2011
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Naruhisa Hirai, Jun Kuwana
  • Patent number: 7906540
    Abstract: Compounds of formula I, wherein R1, R2, R3, R4, R5, X, Y, and Ar are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: March 15, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Zachary Kevin Sweeney, Michael Welch
  • Publication number: 20110009640
    Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
    Type: Application
    Filed: September 21, 2010
    Publication date: January 13, 2011
    Applicant: BASF AKTIENGESELLSCHAFT
    Inventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
  • Patent number: 7858805
    Abstract: The invention relates to processes for the preparation of compounds of general formula (I) and salts thereof: in which Q1 represents O, Q2 represents O, R1 represents —CH3, R2 represents —CH3, R3 represents —OCH3, and R4 represents —CH3.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: December 28, 2010
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ernst Rudolf F. Gesing, Joachim Kluth, Klaus-Helmut Müller, Mark Wilhelm Drewes, Peter Dahem, Dieter Feucht, Rolf Pontzen
  • Publication number: 20100120622
    Abstract: The present invention relates to selective-herbicidal compositions, characterized in that they contain an effective amount of the compound 2-(2-trifluoromethoxy-phenylsulphonylaminocarbonyl)-4-methyl-5-methoxy-2,4-dihydro-3H-1,2,4-triazol-3-one of the formula (I) and/or of salts of the compound of the formula (I), and to the use of these compositions for the selective control of weeds in crops of cereals, in particular crops of wheat, and to methods for the selective control of weeds in crops of cereals by applying the compositions together with surfactants and/or customary extenders.
    Type: Application
    Filed: December 11, 2009
    Publication date: May 13, 2010
    Applicant: Arysta LifeScience North America, LLC
    Inventors: DIETER FEUCHT, Hans-Joachim Santel, Klaus Lürssen, Ingo Wetcholowsky, Peter Dahmen, Klaus-Helmut Müller
  • Publication number: 20100056798
    Abstract: The invention relates to processes for the preparation of compounds of general formula (I) and salts thereof: in which Q1 represents O, Q2 represents O, R1 represents —CH3, R2 represents —CH3, R3 represents —OCH3, and R4 represents —CH3.
    Type: Application
    Filed: November 6, 2009
    Publication date: March 4, 2010
    Applicant: Bayer CropScience AG
    Inventors: Ernst Rudolf F. GESING, Joachim Kluth, Klaus-Helmut Müller, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Patent number: 7651978
    Abstract: The present invention relates to selective-herbicidal compositions, characterized in that they contain an effective amount of the compound 2-(2-trifluoromethoxy-phenylsulphonylaminocarbonyl)-4-methyl-5-methoxy-2,4-dihydro-3H-1,2,4-triazol-3-one of the formula (I) and/or of salts of the compound of the formula (I), and to the use of these compositions for the selective control of weeds in crops of cereals, in particular crops of wheat, and to methods for the selective control of weeds in crops of cereals by applying the compositions together with surfactants and/or customary extenders.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: January 26, 2010
    Assignee: Arysta LifeScience North America, LLC
    Inventors: Dieter Feucht, Hans-Joachim Santel, Klaus Lürssen, Ingo Wetcholowsky, Peter Dahmen, Klaus-Helmut Müller
  • Publication number: 20090274632
    Abstract: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
    Type: Application
    Filed: August 19, 2008
    Publication date: November 5, 2009
    Applicant: Senomyx, Inc.
    Inventors: Xiaodong Li, Andrew Patron, Catherine Tachdjian, Hong Xu, Qing Li, Alexey Pronin, Guy Servant, Lan Zhang, Thomas Brady, Vincent Darmohusodo, Melissa Arellano, Victor Selchau, Brett Weylan Ching, Donald S. Karanewsky, Paul Brust, Jing Ling, Wen Zhao, Chad Priest
  • Patent number: 7511149
    Abstract: Insecticidal sulfoximines are produced efficiently and in high yield by the oxidation of the corresponding sulfilimine with ruthenium tetraoxide or an alkali metal permanganate.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: March 31, 2009
    Assignee: Dow AgroSciences LLC
    Inventors: Kim E. Arndt, Douglas C. Bland, David E. Podhorez, James R. McConnell
  • Publication number: 20090075986
    Abstract: Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.
    Type: Application
    Filed: June 9, 2006
    Publication date: March 19, 2009
    Inventors: Daniel L. Flynn, Peter A. Petillo
  • Publication number: 20080269061
    Abstract: The invention relates to novel substituted thiene-3-ylsulphonylamino(thio)carbonyl-triazolin(ethi)ones of the general formula (I) in which Q1, Q2, R1, R2 R3 and R4 are as defined in the description, except for prior-art compounds. The invention also relates to the preparation of the compounds, to their use as herbicides and to herbicidal compositions comprising the novel compounds.
    Type: Application
    Filed: June 13, 2008
    Publication date: October 30, 2008
    Inventors: Ernst Rudolf F. Gesing, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Publication number: 20080171881
    Abstract: It is desirable to provide a method for easily removing catalyst-derived impurities from a product of a reaction by the catalysis of a compound having a dicarboximide skeleton and thereby efficiently yielding a target compound with high purity. Disclosed is a method for producing an organic compound through a reaction of a substrate in the presence of a catalyst, the catalyst including a compound having a dicarboximide skeleton represented by following Formula (i): wherein R represents hydrogen atom or a hydroxyl-protecting group. The method includes the step of treating a reaction product with hot water so as to decompose and remove an impurity derived from the catalyst. The temperature of the hot water is preferably 100° C. or higher.
    Type: Application
    Filed: March 22, 2006
    Publication date: July 17, 2008
    Inventors: Naruhisa Hirai, Jun Kuwana
  • Publication number: 20080171662
    Abstract: Aminocarbonyl-substituted thiensulfonylamino(thio)carbonyl-triazolin(ethi)ones, processes for their preparation and their use The invention relates to novel substituted thien-3-ylsulfonylamino(thio)carbonyl-triazolin(ethi)ones of the formula (I), in which Q1, Q2, R1, R2, R3, R4 and R5 are as defined in the description, and also to salts of compounds of the formula (I), to processes for their preparation and to their use as herbicides.
    Type: Application
    Filed: July 13, 2005
    Publication date: July 17, 2008
    Inventors: Ernst R. F. Gesing, Thomas Geller, Dieter Feucht, Heinz Kehne, Thomas Auler, Martin Hills
  • Publication number: 20080146544
    Abstract: The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF.
    Type: Application
    Filed: February 25, 2008
    Publication date: June 19, 2008
    Inventors: Timothy L. MacDonald, Jerry L. Nadler, Peng Cui
  • Patent number: 7056941
    Abstract: 2-[Pyrazolyl- and triazolyl-3?-oxymethylene]phenylisoxazolones, -triazolones and -tetrazolones of formula I where: X is a group A, B or C, ?where # denotes the bond with the phenyl ring, Ra is hydrogen, halogen, alkyl or alkoxy, Rb is alkyl; Y is N or CRc, where Rc is hydrogen, halogen or alkyl; n is 0, 1, 2, 3 or 4, where the substituents R1 may be different if n is greater than 1; R1 is nitro, cyano, halogen, alkyl with or without substitution or alkoxy with or without substitution or is additionally, if n is 2, an optionally substituted 3 or 4 membered bridge which forms together with the ring to which it is attached a bicyclic partially unsaturated or aromatic radical; R2 is hydrogen, nitro, cyano, halogen, alkyl, haloalkyl, alkoxy, alkylthio or alkoxycarbonyl; R3 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted hetaryl, their preparation and their use for controlling unwanted animal pests or harmful fungi.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: June 6, 2006
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Müller, Hubert Sauter, Herbert Bayer, Markus Gewehr, Wassilios Grammenos, Thomas Grote, Andreas Gypser, Arne Ptock, Reinhard Kirstgen, Norbert Götz, Roland Götz, Franz Röhl, Eberhard Ammermann, Volker Harries, Gisela Lorenz, Siegfried Strathmann
  • Patent number: 7037880
    Abstract: Ethylene derivatives of formula (I): where Q is an unsubstituted or substituted phenyl or heterocyclic group, especially a 4-thiazolyl, 1- or 3-pyrazolyl, 1,3-oxazol-4-yl, phenyl or pyridyl group; E is a substituent such as a cyano group; A is a substituent such as a 4-pyrazolyl or thiazolyl group; and B is a substituent such as an alkylcarbonyl group. Agricultural chemicals and agents for preventing the attachment of aquatic organisms containing one or more such ethylene derivatives.
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: May 2, 2006
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Tomoyuki Ogura, Hiroshi Murakami, Akira Numata, Rika Miyachi, Toshiro Miyake, Norihiko Mimori, Shinji Takii
  • Patent number: 6969697
    Abstract: The invention relates to novel substituted benzoylcyclohexenones of the formula (I), in which n, A, R1, R2, R3, R4, Y and Z are each as defined in the description, and also to processes for their preparation and to their use as herbicides.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: November 29, 2005
    Assignees: Bayer Aktiengesellschaft, Nihon Bayer Agrochem K. K.
    Inventors: Klaus-Helmut Müller, Hans-Georg Schwarz, Stefan Herrmann, Dorothee Hoischen, Stefan Lehr, Otto Schallner, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen, Akihiko Yanagi, Shinichi Narabu, Toshio Goto, Seishi Ito, Chieko Ueno
  • Patent number: 6964939
    Abstract: The invention relates to novel substituted thien-3-yl-sulphonylamino(thio)carbonyl-triazolin(ethi)ones of the general formula (I) in which Q1, Q2, R1, R2, R3 and R4 are each as defined in the description, and to salts of the compounds according to formula (I), to processes and to novel intermediates for their preparation and to their use as herbicides.
    Type: Grant
    Filed: July 4, 2000
    Date of Patent: November 15, 2005
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ernst Rudolf F. Gesing, Joachim Kluth, Klaus-Helmut Müller, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Patent number: 6762152
    Abstract: The invention relates to novel substituted benzoyl ketones of the formula (I) in which n represents 0, 1, 2 or 3, A represents a single bond or represents alkanediyl (alkylene), R1 represents hydrogen or represents in each case optionally substituted alkyl or cycloalkyl, R2 represents hydrogen, cyano, carbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkoxycarbonyl, alkylthio, alkylsulphinyl or alkylsulphonyl, R3 represents hydrogen, nitro, cyano, carboxyl, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylamino, dialkylamino or dialkylaminosulphonyl, R4 represents nitro, cyano, carboxyl, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylamino, dialkyiamino or dialkylaminosulphonyl, and Z represents an optionally substituted 4- to 12-membered, saturated or u
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: July 13, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus-Helmut Müller, Stefan Lehr, Otto Schallner, Hans-Georg Schwarz, Heinz-Jürgen Wroblowsky, Mark Wilhelm Drewes, Dieter Feucht, Rolf Pontzen, Ingo Wetcholowsky
  • Publication number: 20040102500
    Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-2-alkyl, heteroaryl-C0-2-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C1-C6 alkyl, C3-C6 cycloalkyl and heteroaryl. X is a C2-C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH2)nCOOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C1-C5 alkyl, C1-C5 alkoxy.
    Type: Application
    Filed: September 11, 2003
    Publication date: May 27, 2004
    Inventors: Ivan Collado Cano, Samuel James Dominianni, Garret Jay Etgen, Cristina Garcia-Paredes, Richard Duane Johnston, Michael Edward Letourneau, Nathan Bryan Mantlo, Michael John Martinelli, Daniel Ray Mayhugh, Ashraf Saeed, Richard Craig Thompson, Xiaodong Wang, David Scott Coffey, Christopher Randall Schmid, Jeffrey Thomas Vicenzi, Yanping Xu
  • Patent number: 6727206
    Abstract: The invention relates to novel substituted aryl ketones of the general formula (I) in which n, A, R1, R2, R3, R4 and Z are each as defined in the description, to processes for their preparation and to their use as herbicides.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: April 27, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus-Helmut Müller, Stefan Lehr, Otto Schallner, Hans-Georg Schwarz, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Patent number: 6710049
    Abstract: The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared with presently available agents in this class and the processes for the preparation thereof. This invention also relates to pharmaceutical preparations containing the compounds of the present invention and their use in treating and/or preventing the fungal infections in mammals, preferably humans.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: March 23, 2004
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Mohammed Salman, Rita Katoch, Ashwani Kumar Verma, Jitendra Sattigeri, Ashok Rattan
  • Patent number: 6677277
    Abstract: The invention relates to novel sulfonylamino(thio)carbonyl compounds of the formula (I), in which n represents the numbers 0, 1 or 2, A represents a single bond, or oxygen or sulfur, or the grouping N—R, in which R represents hydrogen, alkyl, alkenyl, alkinyl or cycloalkyl, Q represents oxygen or sulfur, R1 represents hydrogen or formyl, or represents respectively optionally substituted alkyl, alkoxy, alkylamino, alkoxyamino, dialkylamino, N-alkoxy-N-alkyl-amino, alkylcarbonyl, alkoxycarbonyl, alkylsulfonyl, alkenyl, alkinyl, cycloalkyl, cycloalkylcarbonyl or cycloalkylsulfonyl, R2 represents cyano or halogen, or represents respectively optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, dialkylaminosulfonyl, alkenyl, alkinyl, alkenyloxy or alkinyloxy, and R3 represents respectively optionally substituted heterocyclyl having 5 ring members of which at least one is oxygen, sulfur or nitrogen and from one to three further ring members can be nitrogen, an
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: January 13, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Otto Schallner, Mark-Wilhelm Drewes, Kurt Findeisen, Ernst-Rudolf F. Gesing, Johannes-Rudolf Jansen, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Müller, Klaus König, Ulrich Philipp, Hans-Jochem Riebel, Peter Wolfrum, Markus Dollinger
  • Publication number: 20040002599
    Abstract: The invention relates to novel substituted benzoylcyclohexenones of the formula (I), 1
    Type: Application
    Filed: October 21, 2002
    Publication date: January 1, 2004
    Inventors: Klaus-Helmut Muller, Hans-Georg Schwarz, Stefan Herrmann, Dorothee Hoischen, Stefan Lehr, Otto Schallner, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen, Akihiko Yanagi, Shinichi Narabu, Toshio Goto, Seishi Ito, Chieko Ueno
  • Publication number: 20030228983
    Abstract: The invention relates to novel substituted aryl ketones of the general formula (I) 1
    Type: Application
    Filed: April 23, 2003
    Publication date: December 11, 2003
    Inventors: Klaus-Helmut Muller, Stefan Lehr, Otto Schallner, Hans-Georg Schwarz, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Publication number: 20030208073
    Abstract: The invention relates to novel substituted N-aryl nitrogen-containing heterocyclic compounds of the general formula (I) 1
    Type: Application
    Filed: January 29, 2003
    Publication date: November 6, 2003
    Inventors: Karl-Heinz Linker, Kurt Findeisen, Otto Schallner, Andreas Lender, Hans-Joachim Santel, Markus Dollinger, Akihiko Yanagi, Toshio Goto
  • Publication number: 20030144522
    Abstract: The invention relates to novel substituted N-aryl nitrogen-containing heterocyclic compounds of the general formula (I) 1
    Type: Application
    Filed: May 2, 2002
    Publication date: July 31, 2003
    Inventors: Karl-Heinz Linker, Kurt Findeisen, Otto Schallner, Andreas Lender, Hans-Joachim Santel, Markus Dollinger, Akihiko Yanagi, Toshio Goto
  • Patent number: 6600049
    Abstract: A process is described for preparing 1-aryltriazolinones of formula I useful in the production of commercial herbicides: by (i) carbonylating an amidrazone of formula (A) with one or more carbonylating agent, or by (ii) condensing a hydrazonoyl derivative of formula (A) with one or more ring-forming agent, wherein formula (A) is where W, X, Y, Z, and R1 are fully described herein. Preferred are those where W is halogen or —NHR where R is hydrogen or haloalkyl; X and Y are independently selected from hydrogen, chloro, or fluoro; Z is hydrogen, bromo, iodo, nitro, amino, or methylsulfonylamino; and R1 is methyl. Certain compounds of formula (A) are novel compositions of matter. The process as described herein has utility in providing compounds of formula I in unexpectedly high yield and purity.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: July 29, 2003
    Assignee: FMC Corporation
    Inventor: Jaidev S. Goudar
  • Patent number: 6576632
    Abstract: The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b, m, n, p and v are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and methods of treating hyperproliferative disorders in mammals by administering the above compounds.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: June 10, 2003
    Assignee: Pfizer Inc
    Inventors: Steven W. Goldstein, Kelly P. Longo, James F. Blake, Mohamed M. A. Awad, Kenneth P. Raiche, Kevin W. Kramer
  • Patent number: 6573219
    Abstract: The invention relates to novel substituted heterocyclyl-2H-chromenes of the general formula (I) in which R1, R2, R3, R4, R5 Z are each as defined in the description, and to a process for their preparation and to their use as herbicides.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: June 3, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl-Heinz Linker, Roland Andree, Karl-Julius Reubke, Otto Schallner, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Patent number: 6492527
    Abstract: A process is described for preparing 1-aryltriazolinones of formula I useful in the production of commercial herbicides: by (i) carbonylating an amidrazone of formula (A) with one or more carbonylating agent, or by (ii) condensing a hydrazonoyl derivative of formula (A) with one or more ring-forming agent, wherein formula (A) is where W, X, Y, Z, and R1 are fully described herein. Preferred are those where W is halogen or —NHR where R is hydrogen or haloalkyl; X and Y are independently selected from hydrogen, chloro, or fluoro; Z is hydrogen, bromo, iodo, nitro, amino, or methylsulfonylamino; and R1 is methyl. Certain compounds of formula (A) are novel compositions of matter. The process as described herein has utility in providing compounds of formula I in unexpectedly high yield and purity.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: December 10, 2002
    Assignee: FMC Corporation
    Inventor: Jaidev S. Goudar
  • Publication number: 20020123502
    Abstract: The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
    Type: Application
    Filed: December 26, 2001
    Publication date: September 5, 2002
    Applicant: DR. REDDY'S RESEARCH FOUNDATION & REDDY-CHEMINOR, INC.
    Inventors: Vidya Bhushan Lohray, Braj Bhushan Lohray, Rao Bheema Paraselli, Ranga Madhavan Gurram, Rajagopalan Ramanujam, Ranjan Chakrabarti, Sarma K.S. Pakala
  • Patent number: 6426318
    Abstract: The invention relates to novel substituted N-aryl nitrogen-containing heterocyclic compounds of the general formula (I) and to the compounds isomeric to the substituted N-aryl nitrogen-containing heterocyclic compounds of the formula (I), of the formulae (Ia) and (Ib) in which Q1, Q2, R1, R2 and Ar have the meanings given in the description, processes for their preparation and their use as herbicides.
    Type: Grant
    Filed: September 20, 2000
    Date of Patent: July 30, 2002
    Assignees: Bayer Aktiengesellschaft, Nihon Bayer Agrochem KK
    Inventors: Karl-Heinz Linker, Kurt Findeisen, Otto Schallner, Andreas Lender, Hans-Joachim Santel, Markus Dollinger, Akihiko Yanagi, Toshio Goto
  • Patent number: 6383988
    Abstract: The invention relates to novel thienylsulphonylamino(thio)carbonyl compounds of the formula (I), in which Q represents oxygen or sulphur, R1 represents cyano, halogen or in each case optionally cyano-, halogen- or C1-C4-alkoxy-substituted alkyl, alkenyl, alkinyl, alkoxy, alkenyloxy or alkinyloxy having in each case up to 6 carbon atoms, R2 represents cyano, halogen or in each case optionally cyano-, halogen- or C1-C4-alkoxy-substituted alkyl, alkenyl, alkinyl, alkoxy, alkenyloxy or alkinyloxy having in each case up to 6 carbon atoms, and R3 represents in each case optionally substituted heterocyclyl having 5 ring members, at least one of which represents oxygen, sulphur or nitrogen and one to three others may represent nitrogen, and salts of compounds of the formula (I), to processes and novel intermediates for preparing the novel compounds and to their use as herbicides.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: May 7, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus-Helmut Müller, Ernst Rudolf F. Gesing, Mark Wilhelm Drewes, Johannes Rudolf Jansen, Rolf Kirsten, Joachim Kluth, Klaus König, Ulrich Philipp, Markus Dollinger
  • Patent number: 6372744
    Abstract: &bgr;-sheet mimetics and methods relating to the same are disclosed. The &bgr;-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a &bgr;-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.
    Type: Grant
    Filed: February 9, 2000
    Date of Patent: April 16, 2002
    Assignee: Molecumetics Ltd.
    Inventors: Maher N. Qabar, Michael K. McMillan, Michael S. Kahn, John E. Tulinsky, Cyprian O. Ogbu, Jessymol Mathew
  • Patent number: 6350720
    Abstract: The invention relates to new substituted phenyltriazolin(thi)one of the general formula (I), in which Q1, Q2, R1, R2, R3, R4 and R5have the meanings given in the description, and to a process for their preparation and to their use as herbicides.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: February 26, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl-Heinz Linker, Wilhelm Haas, Otto Schallner, Markus Dollinger
  • Patent number: 6288063
    Abstract: Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)xA—B—D—E—G wherein A is an aryl or heteroaryl rings; B is an aryl or heteroaryl ring or a bond; each T is a substituent group; x is 0, 1, or 2; the group D represents the group E represents a two or three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents and with the proviso that when G is each of the substituents on E is an independent substituent; and include pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: September 11, 2001
    Assignee: Bayer Corporation
    Inventors: Harold Clinton Eugene Kluender, David Ross Brittelli, William Riley Schoen, Sookhee Nicole Ha
  • Patent number: 6258751
    Abstract: The present invention relates to novel heterocyclic compounds and their agronomically suitable salts, methods for the use of these compounds in controlling unwanted plant species, and the use of herbicidal compositions containing these compounds. In particular, the present invention pertains to substituted and unsubstituted triazoles, imidazoles and pyrazoles linked to a heterocyclic substituted benzene group. Such compounds are useful as pre-emergent and post-emergent herbicides.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: July 10, 2001
    Assignee: Rohm and Haas Company
    Inventors: Richard Martin Jacobson, Mark Joseph Mulvihill, Changling Liu, Xiaonan Liu
  • Patent number: 6258957
    Abstract: The present invention relates to the use of partly known N-aryl-1,2,4-triazolin-5-ones of the formula (I) in which A, R1, R2, R3, R4 and R5 are each as defined in the description for controlling animal pests.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: July 10, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl-Heinz Linker, Kurt Findeisen, Wilhelm Haas, Andreas Lender, Klaus-Helmut Müller, Otto Schallner, Christoph Erdelen, Andreas Turberg, Norbert Mencke
  • Patent number: RE39607
    Abstract: The invention relates to novel sulphonylamino(thio) carbonyl compounds of the formula (I), in which A represents a single bond, oxygen, sulphur or the group N—R, in which R represents hydrogen, alkyl, alkenyl, alkinyl or cycloalkyl, Q represents oxygen or sulphur, R1 represents hydrogen or formyl or represents in each case optionally substituted alkyl, alkenyl, alkinyl, alkylcarbonyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, cycloalkylcarbonyl or cycloalkylsulphonyl, R2 represents cyano or halogen or represents in each case optionally substituted alkyl, alkenyl, alkinyl, alkoxy, alkenyloxy or alkinyloxy, and R3 represents in each case optionally substituted heterocyclyl having 5 ring members of which at least one is oxygen, sulphur or nitrogen and from one to three further ring members can be nitrogen, and salts of compounds of the formula (I), the previously known compounds 4,5-dimethoxy-2-(2,5-dimethoxy-phenylsulphonylaminocarbonyl)-2,4-dihydro-3H-1,2,4-triazol-3-one, 4,5-diethoxy-2-(2,5-dimetho
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: May 1, 2007
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus-Helmut Müller, Rolf Kirsten, Ernst Rudolf F. Gesing, Joachim Kluth, Mark Wilhelm Drewes, Kurt Findeisen, Johannes Rudolf Jansen, Klaus König, Hans-Jochem Riebel, Otto Schallner, Markus Dollinger, Hans-Joachim Santel