Benzene Ring Bonded Directly At The 2- Position Of The Diazole Ring Patents (Class 548/310.7)
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Publication number: 20130158089Abstract: Treatment of cancer and thromboembolic disorders using inhibitors of Factor VIIa are disclosed herein using a compound of Formula I:Type: ApplicationFiled: November 2, 2012Publication date: June 20, 2013Applicant: PHARMACYCLICS, INC.Inventor: Pharmacyclics, Inc
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Publication number: 20130146856Abstract: Compounds including optionally substituted Ring Systems 1-4 may be used as host in light-emitting devices.Type: ApplicationFiled: February 7, 2013Publication date: June 13, 2013Applicant: NITTO DENKO CORPORATIONInventor: Nitto Denko Corporation
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Publication number: 20130053412Abstract: The invention relates to cyclopentanecarboxamide derivatives of formula 1, to their use as Fatty Acid Synthase inhibitors, to methods for their therapeutic use and to pharmaceutical compositions containing them, wherein R1, R2, R3, LO, W, AR1, n are as defined in claim 1.Type: ApplicationFiled: October 15, 2010Publication date: February 28, 2013Applicant: Boehringer Ingelheim International GmbHInventors: Joerg Kley, Bradford S. Hamilton, Juergen Mack, Norbert Redemann, Corinna Schoelch
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Patent number: 8383832Abstract: Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ib-1: wherein Z, X1, X2, X5, R2b and R10 are as defined herein. Compounds of Formula Ib-1 can be used to prepare heterocyclic derivatives such as benzimidazole derivatives.Type: GrantFiled: September 9, 2011Date of Patent: February 26, 2013Assignees: Array BioPharma Inc., AstraZeneca ABInventors: John Demattei, Sagar Shakya, Anthony D. Piscopio, Bruno P. Hache, Matthew Charles Evans, James Gair Ford, Simon Mark Pointon, Koen Peeters, Timothy John Lilley, John Leonard
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Publication number: 20120313083Abstract: Provided are an organic compound having high heat stability suitable for use in an organic light-emitting device, and an organic light-emitting device using the organic compound. The organic light-emitting device is an organic light-emitting device, including: an anode; a cathode; and an organic compound layer disposed between the anode and the cathode, in which at least one layer of the organic compound layer has a 6,12-dinaphthylchrysene derivative represented by one of the following general formulae (1) and (2): in the formulae (1) and (2), Z represents a naphthyl group, and Q represents an electron-withdrawing substituent selected from the group consisting of the following general formulae (3) to (5): in the formula (5), R1 represents a hydrogen atom or a methyl group.Type: ApplicationFiled: May 25, 2012Publication date: December 13, 2012Applicant: CANON KABUSHIKI KAISHAInventors: Hironobu Iwawaki, Hiroki Ohrui, Yuko Chishina, Masanori Muratsubaki, Tetsuo Takahashi
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Patent number: 8329316Abstract: The present invention provides a novel tetraphenylnaphthalene derivative, and an organic light emitting device using the same.Type: GrantFiled: March 9, 2007Date of Patent: December 11, 2012Assignee: LG Chem, Ltd.Inventors: Yeon-Hwan Kim, Dong-Hoon Lee, Hye-Young Jang, Sung-Kil Hong, Sung-Jin Yeo, Kong-Kyeom Kim, Dong-Seob Jeong, So-Yeon Choi, legal representative
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Publication number: 20120292601Abstract: Novel heteroleptic iridium complexes are provided. These iridium complexes are useful compounds in OLED devices. The ligands for these novel complexes may be obtained using a new synthetic methodology that utilizes manganese dioxide.Type: ApplicationFiled: May 19, 2011Publication date: November 22, 2012Applicant: Universal Display CorporationInventors: Gregg Kottas, Chuanjun Xia, Zeinab Eishenawy, Nasrin Ansari
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Patent number: 8314134Abstract: The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.Type: GrantFiled: March 5, 2010Date of Patent: November 20, 2012Assignee: Synta Pharmaceuticals Corp.Inventors: Shoujun Chen, Jun Jiang, Hao Li, David James, Dinesh Chimmanamada, Christopher Borella, Lijun Sun, Yu Xie, Mats Holmqvist, Jerome Mahiou, Zhiqiang Xia
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Patent number: 8309581Abstract: The present invention relates to compounds of formula (I), as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein A, B, R1, R2, R3, R4, R5, n, m and p have the significance defined herein.Type: GrantFiled: September 20, 2010Date of Patent: November 13, 2012Assignee: Hoffmann-La Roche Inc.Inventors: Gregory Martin Benson, Konrad Bleicher, Song Feng, Uwe Grether, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Markus Rudolph, Sven Taylor
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Publication number: 20120214804Abstract: The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect.Type: ApplicationFiled: October 25, 2010Publication date: August 23, 2012Inventors: Soon Ha Kim, Hyoung Jin Kim, Heui Sul Park, Seon Yeong Gu, Hyo Shin Kwak, Du Hee Park, Hyo Soo Kim, Hyun Jai Cho, Ji Hyun Kim, Ju Young Kim, Kwang Min Park
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Patent number: 8232410Abstract: The present invention relates to novel benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis or Francisella tulerensis by administering to the patient a benzimidazole derivative or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 21, 2008Date of Patent: July 31, 2012Assignee: The Research Foundation of State University of New YorkInventors: Iwao Ojima, Seung-yub Lee
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Publication number: 20120184556Abstract: Disclosed are substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mGluR4 potentiators.Type: ApplicationFiled: July 23, 2010Publication date: July 19, 2012Inventors: P. Jeffrey Conn, Craig W. Lindsley, Corey R. Hopkins, Charles David Weaver, Colleen M. Niswender, Yiu-Yin Cheung
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Patent number: 8222248Abstract: The present invention provides compounds of the following structure; A-L1-B—C-D that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, particularly humans.Type: GrantFiled: October 17, 2007Date of Patent: July 17, 2012Assignee: Novartis AGInventors: Moo Je Sung, Gary Mark Coppola, Taeyoung Yoon, Thomas A. Gilmore
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Publication number: 20120139410Abstract: An organic electroluminescence device includes: a cathode; an anode; and a single-layered or multilayered organic thin-film layer provided between the cathode and the anode. In the organic electroluminescence device, the organic thin-film layer includes at least one emitting layer, and the at least one emitting layer contains: at least one phosphorescent material; and a host material represented by the following formula (1).Type: ApplicationFiled: December 7, 2011Publication date: June 7, 2012Applicant: Idemitsu Kosan Co., Ltd.Inventors: Kazuki NISHIMURA, Toshihiro IWAKUMA, Kenichi FUKUOKA, Chishio HOSOKAWA, Masahiro KAWAMURA, Mitsunori ITO, Yoriyuki TAKASHIMA, Toshinari OGIWARA
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Patent number: 8193370Abstract: Disclosed is an alanine racemase chiral binaphthol derivative having the ability to recognize amino alcohols selectively on the basis of chirality and transform amino acids from an L-form into a D-form. Methods for the optical resolution of amino acid or amino alcohol and for the optical transformation of D- and L-forms of amino acids using the binaphthol derivative are also provided.Type: GrantFiled: October 26, 2010Date of Patent: June 5, 2012Assignee: Aminolux Co., Ltd.Inventors: Kwan Mook Kim, Lijun Tang
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Publication number: 20120132899Abstract: A nitrogen-containing heterocyclic derivative represented by the following formula (1): wherein any “12-a” groups of R1 to R12 are independently a hydrogen atom, a fluorine atom, a substituted or unsubstituted aryl group having 6 to 30 ring carbon atoms or a substituted or unsubstituted heterocyclic group having 5 to 30 ring atoms; any “a” groups of R1 to R12 are independently a single bond which is bonded to L1; L1 is a single bond, a “b+1” valent substituted or unsubstituted hydrocarbon ring group having 6 to 30 ring carbon atoms or a “b+1” valent substituted or unsubstituted heterocyclic group having 5 to 30 ring atoms; HAr is a substituted or unsubstituted nitrogen-containing heterocyclic group; and “a” and “b” are independently an integer of 1 to 4, and at least one of “a” and “b” is 1.Type: ApplicationFiled: January 13, 2011Publication date: May 31, 2012Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Masahiro Kawamura, Yuichiro Kawamura, Sayaka Mizutani, Hirokatsu Ito
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Publication number: 20120126180Abstract: The present invention relates to substituted benz[a]anthracene derivatives, to the preparation and use thereof in organic electroluminescent devices, and to organic electroluminescent devices, in particular blue-emitting devices, in which these compounds are used as matrix material or dopant in the emitting layer and/or as hole-transport material and/or as electron-transport material.Type: ApplicationFiled: July 5, 2010Publication date: May 24, 2012Applicant: Merck Patent GmbHInventors: Amir Hossain Parham, Arne Buesing, Holger Heil, Philipp Stoessel, Michael Holbach
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Publication number: 20120049768Abstract: To provide a novel organic compound having a bipolar property. To reduce power consumption of a light-emitting element, a light-emitting device, and an electronic device. The organic compound has a fluorene skeleton and a structure in which an electron-accepting unit and a hole-accepting unit are bonded through carbon at the 9-position of the fluorene skeleton. The organic compound has a bipolar property and a large band gap. The use of the organic compound makes it possible to reduce power consumption of a light-emitting element, a light-emitting device, and an electronic device.Type: ApplicationFiled: August 26, 2011Publication date: March 1, 2012Inventors: Satoshi Seo, Sachiko Kawakami, Harue Osaka
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Patent number: 8119814Abstract: The present invention provides an aromatic heterocyclic compound represented by Formula 1 below, an organic light-emitting diode including an organic layer comprising the aromatic heterocyclic compound, and a method of manufacturing the organic light-emitting diode: wherein A, Ar1, Ar2, n, m, and k are as described in the detailed description of the present invention.Type: GrantFiled: April 30, 2008Date of Patent: February 21, 2012Assignees: Samsung Electronics Co., Ltd., Samsung Mobile Display Co., Ltd.Inventors: Dong-woo Shin, Myeong-suk Kim, Tae-woo Lee, Yu-jin Kim, Eun-sil Han, Woon-jung Paek, Yu-ri Choi, Byoung-ki Choi, Tae-yong Noh, O-hyun Kwon, Haa-jin Yang, Young-mok Son
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Publication number: 20120028959Abstract: The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.Type: ApplicationFiled: March 26, 2010Publication date: February 2, 2012Applicant: MERCK SERONO S.A.Inventors: Siva Sanjeeva Rao Thunuguntla, Hosahalli Subramanya, Satish Reddy Kunnam, Sekhar Reddy Sanivaru Vijay, Chakrapani Bingi, Raviraj Kusanur, Matthias Schwarz, Michael Arlt
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Patent number: 8106084Abstract: This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrazine compounds having selected substitution patterns are disclosed, and the activity of various subject compounds is demonstrated. For example, the invention provides compounds having the general formula: their pharmaceutical compositions, and methods of treatment using the subject compounds and compositions.Type: GrantFiled: March 3, 2011Date of Patent: January 31, 2012Assignee: Spelman CollegeInventor: Leyte L. Winfield
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Patent number: 8088930Abstract: The invention is concerned with novel benzimidazole derivatives of formula (I) wherein A, n and R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.Type: GrantFiled: September 4, 2009Date of Patent: January 3, 2012Assignee: Hoffmann-La Roche Inc.Inventors: Gregory Martin Benson, Konrad Bleicher, Song Feng, Uwe Grether, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Sven Taylor
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Publication number: 20110306611Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.Type: ApplicationFiled: August 3, 2009Publication date: December 15, 2011Applicant: Paratek Pharmaceuticals, Inc.Inventors: Michael N. Alekshun, Victor Amoo, Oak K. Kim, Atul K. Verma
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Publication number: 20110301146Abstract: GSK-3beta inhibitors comprising 7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives are provided. For example, the inhibitors have following general formula (I).Type: ApplicationFiled: September 29, 2009Publication date: December 8, 2011Applicant: ONCOTHERAPY SCIENCE, INC.Inventors: Yo Matsuo, Ryuji Ohsawa, Shoji Hisada
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Publication number: 20110288292Abstract: The present invention relates to substituted benzo[c]phenanthrene derivatives and to the production and to the use thereof in electronic devices, and to the electronic devices themselves. The present invention relates in particular to benzo[c]phenanthrene derivatives substituted with at least one aromatic unit or at least one diarylamino unit.Type: ApplicationFiled: December 22, 2009Publication date: November 24, 2011Applicant: Merck Patent GmbHInventors: Amir H. Parham, Arne Buesing, Holger Heil, Philipp Stoessel
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Patent number: 8063230Abstract: The present invention relates to tris(N-aryl-benzimidazole)benzene compounds of the formula: where R1-R6, Ar, m, n, p, q, r, and s are defined in the specification. Also provided are compositions comprising tris(N-aryl-benzimidazole)benzene compounds. The invention also relates to use of such compounds in electronic devices.Type: GrantFiled: December 15, 2005Date of Patent: November 22, 2011Assignee: E. I. du Pont de Nemours and CompanyInventors: Steven W. Shuey, William J. Delaney, Eric M. Smith, Ying Wang
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Patent number: 8058450Abstract: A novel nitrogen-containing heterocyclic compound having a specific structure and an organic electroluminescence device comprising an anode, a cathode and an organic thin film layer which comprises a single layer or a plurality of layers comprising at least a light emitting layer and is disposed between the anode and the cathode, wherein at least one layer in the organic thin film layer comprises the above nitrogen-containing heterocyclic derivative singly or as a component of a mixture. The organic electroluminescence device exhibits a great luminance of emitted light and a great efficiency of light emission even under application of a low voltage.Type: GrantFiled: July 7, 2006Date of Patent: November 15, 2011Assignee: Idemitsu Kosan Co., Ltd.Inventors: Chishio Hosokawa, Hiroshi Yamamoto, Takashi Arakane
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Publication number: 20110275663Abstract: The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or acylurea derivatives as such, to their use as a medicinal product, and to pharmaceutical compositions containing them.Type: ApplicationFiled: April 16, 2009Publication date: November 10, 2011Inventors: Martial Ruat, Hélène Faure, Elisabeth Traiffort, Angèle Schoenfelder, André Mann, Maurizio Taddei, Antonio Solinas, Fabrizio Manetti
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Publication number: 20110253994Abstract: A compound for an organic optoelectronic device, an organic optoelectronic device including the same, and a display device including the same, the compound for an organic optoelectronic device being represented by the following Chemical Formula 1:Type: ApplicationFiled: June 29, 2011Publication date: October 20, 2011Inventors: Hyung-Sun Kim, Ho-Jae Lee, Sung-Hyun Jung, Young-Sung Park, Eun-Sun Yu, Mi-Young Chae, Young-Hoon Kim, Ja-Hyun Kim
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Patent number: 8039638Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3 and R4 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV replication, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.Type: GrantFiled: December 3, 2007Date of Patent: October 18, 2011Assignee: Boehringer Ingelheim International GmbHInventors: Christiane Yoakim, Patrick Deroy, Martin Duplessis, Alexandre Gagnon, Sylvie Goulet, Oliver Hucke, Christopher Lemke, Simon Suprenant
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Patent number: 8039637Abstract: Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ia-1 and their synthetic intermediates: wherein Z, X1, X2, X5, R2 and R10 are as defined herein. Compounds of Formula Ia-1 and their synthetic intermediates can be used to prepare heterocyclic derivatives such as benzimidazole derivatives.Type: GrantFiled: June 21, 2006Date of Patent: October 18, 2011Assignee: Array BioPharma Inc.Inventors: John DeMattei, Sagar Shakya, Anthony D. Piscopio, Bruno P. Hache, Matthew Charles Evans, James Gair Ford, Simon Mark Pointon, Koen Peeters, Timothy John Lilley, John Leonard
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Publication number: 20110251401Abstract: Polyphenylene compounds such as compounds represented by Formula I may be used in electronic devices such as organic light-emitting devices. For example, the compounds may be used as host materials in a light-emitting layer.Type: ApplicationFiled: June 22, 2011Publication date: October 13, 2011Applicant: Nitto Denko CorporationInventors: Shijun Zheng, Rebecca Bottger
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Publication number: 20110240980Abstract: In accordance with various embodiments, an organic electronic device includes an n-type dopant material including an imidazole-based material having a hydrogen-based material bonded between nitrogen atoms. The n-type dopant material n-dopes an organic material, and can be used to mitigate degradation in mobility due to conditions such as exposure to ambient atmosphere, which can effect an undesirable reduction in charge transport. Other embodiments are directed to carbon nanotubes or graphene structures with this type of n-type dopant, wherein the Fermi level for the carbon nanotubes or graphene structures is below ?2.5 eV to effect such n-type doping.Type: ApplicationFiled: April 5, 2011Publication date: October 6, 2011Inventors: Peng Wei, Zhenan Bao
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Patent number: 8030497Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof: wherein R1-R7 are as disclosed in the specification.Type: GrantFiled: January 13, 2005Date of Patent: October 4, 2011Assignee: Novartis AGInventors: Marc Gerspacher, Sven Weiler
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Publication number: 20110210320Abstract: The present invention relates to an anthracene derivative and an organic electroluminescent device using the same. More specifically, the present invention relates to: a novel compound which has a core (for example, an indenoanthracene core) where both an anthracene moiety with excellent device characteristics and a fluorene moiety with excellent fluorescent properties are fused, wherein substituents (for example, a heterocyclic group such as a benzimidazole group, a benzothiazole group, a benzoxazole group, a pyridinyl group or a bipyridinyl group) with an electron transfer capacity are substituted to the core; and an organic electroluminescence element which has improved luminous efficiency, brightness, thermal stability, driving voltage, and lifetime, by comprising an organic layer which is positioned between a positive electrode and negative electrode and contains the novel compound.Type: ApplicationFiled: September 1, 2009Publication date: September 1, 2011Applicant: DOOSAN CORPORATIONInventors: Chang-Ju Shin, Tae-Hyung Kim, Kyoung-Soo Kim, Jung-Sub Lee
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Patent number: 7999117Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.Type: GrantFiled: March 30, 2009Date of Patent: August 16, 2011Inventors: Vincent L. Giranda, Thomas D. Penning, Virajkumar B. Gandhi, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong
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Publication number: 20110195932Abstract: Combinations comprising (or consisting essentially of) one or more compounds of formula (1) with one or more ancillary agents, to processes for preparing the combinations, and to various therapeutic uses of the combinations. Also provided are pharmaceutical compositions containing the combinations as well as a method of treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia using the combinations.Type: ApplicationFiled: August 1, 2008Publication date: August 11, 2011Inventors: Graham Michael Wynne, Stephen Paul Wren, Peter David Johnson, Paul Damien Price, Olivier De Moor, Gary Nugent, Richard Storer, Richard Joseph Pye, Colin Richard Dorgan
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Publication number: 20110140093Abstract: Compounds including optionally substituted Ring Systems 1-4 may be used as hosts in light-emitting devices.Type: ApplicationFiled: February 23, 2011Publication date: June 16, 2011Inventors: Shijun Zheng, Liping Ma, Amane Mochizuki
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Patent number: 7947723Abstract: This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrizine compounds having selected substitution patterns are disclosed, and the activity of various subject compounds is demonstrated. For example, the invention provides compounds having the general formula: their pharmaceutical compositions, and methods of treatment using the subject compounds and compositions.Type: GrantFiled: January 30, 2009Date of Patent: May 24, 2011Assignee: Spelman CollegeInventor: Leyte L. Winfield
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Publication number: 20110095282Abstract: The invention relates to organic electroluminescent devices which comprise triazine derivatives as the electron transport material.Type: ApplicationFiled: November 26, 2009Publication date: April 28, 2011Applicant: Merck Patent GmbHInventors: Christof Pflumm, Simone Leu, Joachim Kaiser, Amir Hossain Parham, Frank Voges, Jonas Valentin Kroeber, Arne Buesing
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Publication number: 20110077273Abstract: The present invention relates to compounds of formula (I), as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein A, B, R1, R2, R3, R4, R5, n, m and p have the significance defined herein.Type: ApplicationFiled: September 20, 2010Publication date: March 31, 2011Inventors: Gregory Martin Benson, Konrad Bleicher, Song Feng, Uwe Grether, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Markus Rudolph, Sven Taylor
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Patent number: 7915299Abstract: The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.Type: GrantFiled: November 15, 2007Date of Patent: March 29, 2011Assignee: High Point Pharmaceuticals, LLCInventors: Anders Klarskov Petersen, Preben Houlberg Olesen, Lise Brown Christiansen, Holger Claus Hansen, Flemming Elmelund Nielsen
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Publication number: 20110046133Abstract: The present invention provides compounds of the following structure; A-L1-B-C-D that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, particularly humans.Type: ApplicationFiled: October 17, 2007Publication date: February 24, 2011Inventors: Moo Je Sung, Gary Mark Coppola, Taeyoung Yoon, Thomas A. Gilmore
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Publication number: 20110039895Abstract: The invention described herein relates to certain benzimidazol-4-ylcarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.Type: ApplicationFiled: April 29, 2009Publication date: February 17, 2011Inventors: Deping Chai, Duke M. Fitch
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Publication number: 20110040101Abstract: Disclosed is an alanine racemase chiral binaphthol derivative having the ability to recognize amino alcohols selectively on the basis of chirality and transform amino acids from an L-form into a D-form. Methods for the optical resolution of amino acid or amino alcohol and for the optical transformation of D- and L-forms of amino acids using the binaphthol derivative are also provided.Type: ApplicationFiled: October 26, 2010Publication date: February 17, 2011Applicant: GREEN FORMULA CO. LTD.Inventors: Kim Kwan Mook, Tang Lijun
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Publication number: 20110021532Abstract: Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).Type: ApplicationFiled: April 21, 2009Publication date: January 27, 2011Inventors: David Powell, Marie-Eve Lebrun, Sathesh Bhat, Yeeman K. Ramtohul
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Publication number: 20110012092Abstract: A novel nitrogen-containing heterocyclic derivative having a specific structure. An organic electroluminescence device comprises an organic thin-film layer which is disposed between a cathode and an anode and comprises one or more layers having a light emitting layer. At least one layer of the organic thin-film layer comprises the nitrogen-containing heterocyclic derivative. The organic electroluminescence device exhibits a high luminance and a high luminous efficiency even at a low driving voltage.Type: ApplicationFiled: December 24, 2008Publication date: January 20, 2011Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Hiroshi Yamamoto, Takashi Arakane
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Publication number: 20100326526Abstract: Disclosed herein are compounds represented by Formula 1, wherein R1, Ar1, X, Ar2, Ara, and Het are described herein. Compositions and light-emitting devices related thereto are also disclosed.Type: ApplicationFiled: June 29, 2010Publication date: December 30, 2010Applicant: NITTO DENKO CORPORATIONInventors: SHIJUN ZHENG, JENSEN CAYAS, SHENG LI, AMANE MOCHIZUKI, HYUNSIK CHAE, BRETT T. HARDING
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Publication number: 20100327270Abstract: The present invention relates to the compounds of the formula (1) and to organic electroluminescent devices, in particular blue-emitting devices, in which these compounds are used as host material in the emitting layer and/or as electron-transport material.Type: ApplicationFiled: February 13, 2009Publication date: December 30, 2010Applicant: Merck Patent GmbHInventors: Arne Buesing, Holger Heil, Philipp Stoessel
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Publication number: 20100256203Abstract: The present invention relates to novel benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis or Francisella tulerensis by administering to the patient a benzimidazole derivative or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: April 21, 2008Publication date: October 7, 2010Inventors: Iwao Ojima, Seung-yub Lee