The Additional Polycyclo Ring System Is A Bicyclo Ring System Having Nitrogen As The Only Ring Hetero Atom [e.g., 5-(indolyl-3-methylene)- Hydantoin, Etc.] Patents (Class 548/312.1)
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Publication number: 20040002527Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.Type: ApplicationFiled: May 9, 2003Publication date: January 1, 2004Applicant: WyethInventors: Derek Cecil Cole, Michael Gerard Kelly, David Scott Nunn, Lynne Padilla Greenblatt
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Publication number: 20030232843Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.Type: ApplicationFiled: May 9, 2003Publication date: December 18, 2003Applicant: WyethInventors: Derek Cecil Cole, Michael Gerard Kelly, Byron Abel Bravo, Yvette Latko Palmer
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Publication number: 20030229229Abstract: The present invention refers to a process for preparing indolinone derivatives of the general formula (VI) as defined in the specification and intermediates of that process.Type: ApplicationFiled: February 14, 2003Publication date: December 11, 2003Inventors: Qingwu Jin, Michael A. Mauragis, Paul D. May
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Publication number: 20030229120Abstract: Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.Type: ApplicationFiled: May 14, 2003Publication date: December 11, 2003Inventors: Helle Birk Olsen, Niels C. kaarsholm, Peter Madsen, Soren Ostergaard, Svend Ludvigsen, Palle Jakobsen, Anders Klarskov Petersen, Dorte Bjerre Steensgaard
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Publication number: 20030229091Abstract: Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): 1Type: ApplicationFiled: September 5, 2002Publication date: December 11, 2003Inventors: Andreas Termin, Peter D.J. Grootenhuis, Dean M. Wilson, Valentina Molteni, Long Mao, Angelo Castellino, Zhicai Yang, Anthony Pechulis, Mark Suto
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Publication number: 20030224999Abstract: The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.Type: ApplicationFiled: March 31, 2003Publication date: December 4, 2003Inventors: Han-Cheng Zhang, William J. Hoekstra, Bruce E. Maryanoff, David F. McComsey
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Publication number: 20030220319Abstract: This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: 1Type: ApplicationFiled: January 31, 2003Publication date: November 27, 2003Inventors: Robert Greenhouse, Saul Jaime-Figueroa, Lubica Raptova
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Patent number: 6653308Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.Type: GrantFiled: February 15, 2002Date of Patent: November 25, 2003Assignees: Sugen, Inc., Pharmacia & Upjohn CompanyInventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul M. Herrinton, Michael A. Mauragis
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Patent number: 6649613Abstract: Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R1, 2 and R3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be used to combat thromboses, myocardial infarcts, coronary cardiac diseases, arteriosclerosis, inflammations, tumors, osteoporosis, infections, and restenosis following angioplasty or during pathological processes that are maintained or propagated by angiogenesis.Type: GrantFiled: January 14, 2002Date of Patent: November 18, 2003Assignee: Merck Patent GmbHInventors: Günter Hölzemann, Simon Goodman, Horst Kessler, Christoph Gibson, Gabór Sulyok
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Publication number: 20030199689Abstract: The present invention relates to compounds of formula I, 1Type: ApplicationFiled: November 21, 2002Publication date: October 23, 2003Inventors: Marc Nazare, Melanie Essrich, David William Will, Hans Matter, Kurt Ritter, Volkmar Wehner
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Patent number: 6635771Abstract: Compounds of the formula in which R, R′, R7-R11, X, n1 and n3 are as defined herein. These compounds are useful as intermediates for preparing pharmaceutical compounds having pharmacological activity as chemical inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes.Type: GrantFiled: November 22, 2002Date of Patent: October 21, 2003Assignee: WyethInventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
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Publication number: 20030191128Abstract: The present invention relates to novel imidazoly 2-indolinones and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.Type: ApplicationFiled: February 25, 2003Publication date: October 9, 2003Applicant: SUGEN, INC.Inventors: Peng Cho Tang, Li Sun, Gerald McMahon, G. Davis Harris
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Publication number: 20030187275Abstract: The invention provides improved and simplified methods of synthesizing ligands containing a heteroatom-bearing bridge using a novel intermediate compound. The ligands may be used to form metal complexes that are useful in diagnostic and therapeutic applications.Type: ApplicationFiled: August 22, 2002Publication date: October 2, 2003Inventor: Kondareddiar Ramalingam
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Publication number: 20030181499Abstract: A compound of the formula: 1Type: ApplicationFiled: September 30, 2002Publication date: September 25, 2003Inventors: Toshio Fujishita, Tomokazu Yoshinaga
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Publication number: 20030181447Abstract: This invention is directed to 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives useful as &dgr;-opioid or &mgr;-opioid receptor modulators. Depending on their agonist or antagonist effect, the compounds are useful analgesics, immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.Type: ApplicationFiled: February 7, 2003Publication date: September 25, 2003Inventors: Robert E. Boyd, John R. Carson, Steven J. Coats, Lou Anne Neilson, Philip M. Pitis, Wu-Nan Wu
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Patent number: 6620826Abstract: Novel N-phenyl imidazole derivatives, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.Type: GrantFiled: January 29, 2003Date of Patent: September 16, 2003Assignee: SmithKline Beecham CorporationInventors: John Duncan Elliott, Joseph Weinstock, Jia-Ning Xiang
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Publication number: 20030171353Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.Type: ApplicationFiled: December 19, 2002Publication date: September 11, 2003Applicant: WyethInventors: Derek Cecil Cole, Joseph Raymond Stock, William Joseph Lennox, Ping Zhou
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Publication number: 20030171354Abstract: The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicament, a method of therapeutic treatment using such a compound and processes for producing the compounds.Type: ApplicationFiled: August 21, 2002Publication date: September 11, 2003Applicant: AstraZeneca ABInventors: Michael Wardleworth, Alexander Graham Dossetter, Christopher Thomas Halsall
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Publication number: 20030158405Abstract: Compounds of the formula 1Type: ApplicationFiled: November 22, 2002Publication date: August 21, 2003Applicant: WyethInventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
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Publication number: 20030158194Abstract: The subject invention pertains to novel compounds (and salts thereof), and compositions comprising the compounds, for the treatment of cardiac arrhythmias. The subject invention further concerns methods of making the novel compounds. The novel compounds are rapidly metabolized analogs of amiodarone, having the distinct and advantageous characteristic of being metabolized to a less lipophilic compound. This results in an improved safety profile. The new compounds have particular utility for treating life-threatening ventricular tachyarrhythmias, especially in patients with congestive heart failure (CHF). The compounds also provide effective management for ventricular arrhythmias and supraventricular arrhythmias, including atrial fibrillation and re-entrant tachyarrhythmias involving accessory pathways.Type: ApplicationFiled: December 10, 2002Publication date: August 21, 2003Inventor: Pascal Druzgala
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Patent number: 6608099Abstract: A class of novel acylsulfonamide substituted indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases.Type: GrantFiled: January 30, 2001Date of Patent: August 19, 2003Assignee: Eli Lilly and CompanyInventors: Edward David Mihelich, Michael LeRoy Phillips, Alan M Warshawsky
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Publication number: 20030153763Abstract: The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthridinyl compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.Type: ApplicationFiled: December 17, 2002Publication date: August 14, 2003Inventors: N. Laxma Reddy, Michael Maillard, David Berlove, Sharad Magar, Graham J. Durant
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Publication number: 20030153754Abstract: Disclosed are the compounds of the formula: 1Type: ApplicationFiled: November 22, 2002Publication date: August 14, 2003Applicant: Neurogen Corporation, A Corporation of the State of DelawareInventors: Pamela Albaugh, Gang Liu, Kenneth Shaw, Alan Hutchison
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Publication number: 20030153567Abstract: Novel N-phenyl imidazole derivatives, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.Type: ApplicationFiled: January 29, 2003Publication date: August 14, 2003Applicant: SmithKline Beecham CorporationInventors: John Duncan Elliott, Joseph Weinstock, Jia-Ning Xiang
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Publication number: 20030149050Abstract: The invention provides a novel class of substituted isoindolinone derivatives. Pharmaceutical compositions, and methods of making and using the compounds, or pharmaceutically acceptable salts, hydrates, prodrugs, or mixtures thereof are also described.Type: ApplicationFiled: December 16, 2002Publication date: August 7, 2003Applicant: Inotek Corp.Inventors: Prakash Jagtap, Garry Southan, Andrew Salzman, Csaba Szabo, Siya Ram
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Publication number: 20030144282Abstract: This invention provides substituted indole compounds of the general formula: 1Type: ApplicationFiled: November 22, 2002Publication date: July 31, 2003Applicant: WyethInventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
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Patent number: 6599902Abstract: The present invention relates to certain 5-aralkylsulfonyl-3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular met kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.Type: GrantFiled: May 30, 2002Date of Patent: July 29, 2003Assignee: Sugen, Inc.Inventors: Jingrong Cui, John Ramphal, Congxin Liang, Connie Li Sun, Chung Chen Wei, Peng Cho Tang
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Patent number: 6596738Abstract: Heterocyclic compounds of the following formula: wherein B is [wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or lower alkyl; and X is hydrogen or hydroxy protective group], lower alkanoyl or hydroxyimino(lower)alkyl A is lower alkylene; W is heterocyclic or carbocyclic group, each of which may have one or more substituent(s); Z is heterocyclic group selected from the group consisting of imidazolyl, triazolyl,imidazopyridyl and adenyl, each of which may have one or more substituent(s); or a salt thereof, provided that when W is aryl which may have one or more substituent(s), then (i) Z is triazolyl, imidazopyridyl or adenyl, each of which may have one or more substituent(s); (ii) Z is imidazolyl which may have one or more substituent(s) and B is lower alkanoyl or hydroxyimino(lower)alkyl; or (iii) Z is imidazolyl which may have one or more substituent(s) and R1 and R2 are both lower alkyl.Type: GrantFiled: September 7, 2001Date of Patent: July 22, 2003Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Tadashi Terasaka, Nobuo Seki, Kiyoshi Tsuji, Isao Nakanishi, Takayoshi Kinoshita, Katsuya Nakamura
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Publication number: 20030134886Abstract: The present invention relates to compounds of formula (I) 1Type: ApplicationFiled: November 6, 2002Publication date: July 17, 2003Applicant: ASTRAZENECA AB, a Swedish CorporationInventors: Kostas Karabelas, Matti Lepisto, Peter Sjo
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Patent number: 6586447Abstract: The present invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein n is 0 or 1 and R1, R2, R3, R4, and R5 are as defined herein. The above compounds of formula 1 are useful in the treatment of hyperproliferative disorders, such as cancer, in mammals. The invention also relates to pharmaceutical compositions containing the compounds of formula 1, to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering the compounds of formula 1 to a mammal requiring such treatment, and to methods of preparing compounds of formula 1.Type: GrantFiled: March 31, 2000Date of Patent: July 1, 2003Assignee: Pfizer IncInventors: Joseph Peter Lyssikatos, Bingwei Vera Yang
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Publication number: 20030114667Abstract: The present invention relates to a process for the preparation of compounds of the formula (I) 1Type: ApplicationFiled: March 26, 2002Publication date: June 19, 2003Inventors: Hermann Seifert, Uwe Stelzer
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Publication number: 20030105140Abstract: The present invention is directed to substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs thereof, represented by the general Formula I: 1Type: ApplicationFiled: November 19, 2002Publication date: June 5, 2003Applicant: Cytovia, Inc.Inventors: Sui Xiong Cai, John A. Drewe, Han-Zhong Zhang
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Publication number: 20030105147Abstract: This invention is directed to novel indole and benzothiazole compounds which are selective for cloned human alpha 2 receptors. This invention is also related to uses of these compounds for any indication where use of an alpha 2 agonist may be appropriate. specifically, this includes use as analgesic, sedative and anaesthetic agents. In addition, this invention includes using such compounds for lowering intraocular pressure, presbyopia, treating migraine, hypertension, alcohol withdrawal, drug addiction, rheumatoid arthritis, ischemic pain, spasticity, diarrhea, nasal decongestion, urinary incontinence as well as for use as cognition enhancers and ocular vasoconstriction agents. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.Type: ApplicationFiled: October 22, 2002Publication date: June 5, 2003Applicant: SYNAPTIC PHARMACEUTICAL CORPORATIONInventors: Yoon T. Jeon, Charles Gluchowski
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Patent number: 6573293Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.Type: GrantFiled: February 15, 2001Date of Patent: June 3, 2003Assignees: Sugen, Inc., Pharmacia & Upjohn Co.Inventors: Peng Cho Tang, Todd A. Miller, Xiaoyuan Li, Li Sun, Chung Chen Wei, Shahrzad Shirazian, Congxin Liang, Tomas Vojkovsky, Asaad S. Nematalla, Michael Hawley
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Patent number: 6569868Abstract: The present invention relates to novel imidazoly 2-indolinones and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.Type: GrantFiled: July 6, 2001Date of Patent: May 27, 2003Assignee: Sugen, Inc.Inventors: Peng Cho Tang, Li Sun, Gerald McMahon, G. David Harris
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Publication number: 20030096836Abstract: Disclosed is a compound represented by Structural Formula (I): 1Type: ApplicationFiled: August 29, 2002Publication date: May 22, 2003Applicant: SBR Pharmaceuticals Corp.Inventors: Keizo Koya, Lijun Sun, Mitsunori Ono, David James, Weiwen Ying, Shoujun Chen
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Publication number: 20030092741Abstract: Aspects of the present invention are directed towards compounds of Formula I for the treatment of human erectile disorders including erectile dysfunction in men.Type: ApplicationFiled: August 9, 2002Publication date: May 15, 2003Inventors: Duane D. Miller, Seoung-Soo Hong
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Patent number: 6562816Abstract: The invention provides compounds of Formula I: compounds of the Formula I: wherein R1, R2, R4, R6, X, and W are defined herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which &agr;7 is known to be involved.Type: GrantFiled: August 14, 2002Date of Patent: May 13, 2003Assignee: Pharmacia & Upjohn CompanyInventors: Donn G. Wishka, Jason K. Myers, Bruce N. Rogers, Eric Jon Jacobsen, David W. Piotrowski, Jeffrey W. Corbett, Alice L. Bodnar, Vincent E. Groppi, Jr.
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Publication number: 20030083344Abstract: Compounds of the formula (I), in which M, A1, A2, K1 and K2 have the meanings indicated in the description are novel active tryptase inhibitors.Type: ApplicationFiled: September 20, 2002Publication date: May 1, 2003Inventor: Thomas Martin
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Patent number: 6545162Abstract: The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.Type: GrantFiled: July 22, 1999Date of Patent: April 8, 2003Assignee: California Institute of TechnologyInventors: Peter B. Dervan, Eldon E Baird
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Patent number: 6528650Abstract: The invention relates to novel 4-hydroxyindole derivatives comprising at least one cationic group Z, Z being selected from quaternized aliphatic chains, aliphatic chains containing at least one quaternized saturated ring, and aliphatic chains containing at least one quaternized unsaturated ring, to their use as a coupler for the oxidation dyeing of keratinous fibers, to the dyeing compositions comprising them, and to the methods of oxidation dyeing which employ them.Type: GrantFiled: August 9, 2001Date of Patent: March 4, 2003Assignee: L'Oreal S.A.Inventors: Eric Terranova, Aziz Fadli, Alain LaGrange
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Patent number: 6528513Abstract: Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.Type: GrantFiled: December 15, 2000Date of Patent: March 4, 2003Assignee: Tularik INCInventors: Timothy D. Cushing, Heather L. Mellon, Juan C. Jaen, John A. Flygare, Shi-Chang Miao, Xiaoqi Chen, Jay P. Powers
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Patent number: 6518257Abstract: To provide a composition having a steroid C17,20-lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: wherein R is a hydrogen atom or a protecting group, R1 is a lower alkyl group or a cyclic hydrocarbon group, R2 is an aromatic hydrocarbon group optionally having substituents or an aromatic heterocyclic group optionally having substituents, R3 is a hydrocarbon group optionally having substituents, a hydroxyl group optionally having substituents, a thiol group optionally having substituents, an amino group optionally having substituents, an acyl group or a halogen atom, and n is an integer of 0 to 4, and a salt thereof have a steroid C17,20-lyase inhibitory activity, and are useful as an agent for the pophylaxis or treatment of prostatism and tumors such as beast cancer and the like.Type: GrantFiled: April 18, 2002Date of Patent: February 11, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Akihiro Tasaka, Tomohiro Kaku, Masami Kusaka
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Patent number: 6503938Abstract: 2-phenylindoles are described, as well as a process for making them, pharmaceutical preparations that contain them, methods of using them as pharmaceutical agents.Type: GrantFiled: May 26, 2000Date of Patent: January 7, 2003Assignee: Schering AktiengesellschaftInventors: Erwin Von Angerer, Christian Biberger, Martin Schneider
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Publication number: 20030004342Abstract: The present invention is directed to imidazolyl derivatives of formula (II), wherein the variables are defined in the specification, which are useful as prenyl transeferase inhibitors.Type: ApplicationFiled: May 20, 2002Publication date: January 2, 2003Applicant: Biomeasure, Inc., a Massachusetts corporationInventors: Zheng Xin Dong, Yeelana Shen
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Publication number: 20020193415Abstract: The invention as disclosed herein is a method and composition for the treatment of HIV in humans and other host animals, that includes the administration of an effective HIV treatment amount of a phenylindole as described herein or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier. The compounds of this invention either possess antiviral (i.e., anti-HIV) activity, or are metabolized to a compound that exhibits such activity.Type: ApplicationFiled: April 11, 2002Publication date: December 19, 2002Inventors: Paulo LaColla, Marino Artico, Jean-Pierre Sommadossi
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Publication number: 20020187978Abstract: The present invention relates to certain 4-heteroaryl-3-heteroarylidenyl-2-indolinones compounds and their physiologically acceptable salts which modulate the activity of protein kinases (“PKs”), in particular CDK2. The compounds of the present invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical composition containing these compounds and methods of preparing these compounds are also described.Type: ApplicationFiled: June 29, 2001Publication date: December 12, 2002Inventors: Peng Cho Tang, Chung Chen Wei, Ping Huang, Jingrong Cui
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Patent number: 6492409Abstract: The present invention relates to compounds of formula (I) wherein: Ar1 or Ar2 is an optionally substituted indole, and the other group is an optionally substituted aromatic or heteroaromatic group, suitably an optionally substituted bicyclic heteroaromatic group, preferably an optionally substituted indole, X is O or S, R is H, OH, NH2, C1-6alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl, and R1 is H, C1-6alkyl, fluoro substituted C1-6alkyl, phenyl, benzyl, carboC1-6alkoxy, carbobensyloxy, carbohydroxy, carbamoyl, or methyl(N-C1-6alkylcarbamoyl) and salts and solvates thereof and solvates of such salts, and the use of such compounds in medical therapies.Type: GrantFiled: January 12, 2001Date of Patent: December 10, 2002Assignee: Astrazeneca ABInventors: Kostas Karabelas, Matti Lepistö, Peter Sjö
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Patent number: 6489475Abstract: Heterocyclic derivatives of the formula (I) wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof and method of producing them. Pharmaceutical compositions containing the heterocyclic derivative or a pharmaceutically acceptable salt thereof, particularly, ACAT inhibitors and lipoperoxidation inhibitors. The heterocyclic derivatives and pharmaceutically acceptable salts thereof of the present invention show superior ACAT inhibitory activity and lipoperoxidation inhibitory activity, and are useful as ACAT inhibitors and hyperlipemia inhibitors. To be specific, they are useful for the prevention and treatment of arteriosclerotic lesions of arteriosclerosis, hyperlipemia and diabetes, as well as ischemic diseases of brain, heart and the like.Type: GrantFiled: February 15, 2001Date of Patent: December 3, 2002Assignee: Sankyo Company, LimitedInventors: Hiroshi Matsui, Shoji Kamiya
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Patent number: RE38132Abstract: A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules.Type: GrantFiled: June 12, 2002Date of Patent: June 3, 2003Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Terence A. Kelly, Barbara Jean Bormann, Leah Lynn Frye, Jiang-Ping Wu