Acyclic Chalcogen Bonded Directly At The 2- And At The 4- Or 5- Positions Of Each Of The Two Diazole Rings (e.g., N, N Methylene Bis -hydantoin, Etc.) Patents (Class 548/314.1)
Abstract: The subject matter of the present application is novel imidazolidine-2,4-dione derivatives. These products have an antiproliferative activity. They are particularly advantageous for treating pathological conditions and diseases associated with abnormal cell proliferation, such as cancers. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for preparing a medicament.
Abstract: The subject matter of the present application is novel imidazolidine-2,4-dione derivatives of general formula (I) in which R1, R2, R3 and X are variables. These products have an anti-proliferative activity. They are particularly advantageous for treating pathological conditions and diseases associated with abnormal cell proliferation, such as cancers. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for preparing a medicament.
Abstract: This invention is directed to aroyl pyrrole heteroaryl methanone and methanol compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.
Type:
Grant
Filed:
December 10, 2002
Date of Patent:
May 24, 2005
Assignee:
Ortho-McNeil Pharmaceutical, Inc.
Inventors:
John R. Carson, Ellen E. Codd, Philip M. Pitis
Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
Type:
Application
Filed:
December 9, 2003
Publication date:
June 24, 2004
Inventors:
Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
Abstract: The present invention provides novel compounds possessing antibacterial, antifungal, antiviral, anticancer, and/or antiparasitic activities. Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
Type:
Application
Filed:
September 18, 2003
Publication date:
April 1, 2004
Inventors:
Janos Botyanszki, Dong-Fang Shi, Christopher Don Roberts, Mikail Hakan Gezginci, Stephen Corey Valdez, Sherwin Sattarzadeh
Abstract: Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): 1
Type:
Application
Filed:
September 5, 2002
Publication date:
December 11, 2003
Inventors:
Andreas Termin, Peter D.J. Grootenhuis, Dean M. Wilson, Valentina Molteni, Long Mao, Angelo Castellino, Zhicai Yang, Anthony Pechulis, Mark Suto
Abstract: The present invention relates to phenolic acid derivatives of the formula I and compositions for the preventing and the treating blood lipid level-related diseases comprising the phenolic acid derivatives. The compounds have excellent effects of reducing blood lipid level, inhibiting cholesterol metabolism-related enzymes and preventing and treating blood lipid level-related diseases.
Abstract: Non-peptide somatostatin receptor ligands with conformationally restricted side chains exhibiting high binding affinity toward somatostatin receptors are provided. The compounds exhibit a high selectivity and act as agonists at human subtype 2 somatostatin receptors. The compounds are long acting for advantageous use as medicaments in peripheral diseases where somatostatinergic therapy is indicated. Furthermore, many of the compounds are lipophilic and are particularly useful for treating central nervous system and ophthalmic diseases where penetration of the blood brain and blood retinal barriers is required. It is a further object to describe the preferred stereoisomers of these somatostatin agonists and processes for their preparation. Further objects will become apparent from reading the following description.
Type:
Application
Filed:
November 7, 2002
Publication date:
October 9, 2003
Inventors:
Gideon Shapiro, Michael G. Natchus, Mark A. Lockwood, Simona Jurczyk
Abstract: This invention is directed to aroyl pyrrole heteroaryl methanone and methanol compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.
Type:
Application
Filed:
December 10, 2002
Publication date:
September 25, 2003
Inventors:
John R. Carson, Ellen E. Codd, Philip M. Pitis
Abstract: Small molecule polyamides that specifically bind with subnanomolar affinity to any predetermined sequence in the human genome with potential use in molecular biology and human medicine are described. Further, the designed compounds which target the minor groove of B-form double helical DNA offer a general approach for the control of gene-expression. Simple rules are disclosed which provide for rational control of the DNA-binding sequence specificity of synthetic polyamides containing N-methylpyrrole and N-methylimidazole amino acids. A series of molecular templates for polyamide design are disclosed which provide for small molecules which recognize predetermined DNA sequences with affinities and specificities comparable to sequence-specific DNA-binding proteins such as transcription factors. These design rule are applied to provide a polyamide for specific targeting of a predetermined 7 base pair sequence from a conserved HIV gene promoter at subnanomolar concentration.
Abstract: The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
Type:
Application
Filed:
December 26, 2001
Publication date:
September 5, 2002
Applicant:
DR. REDDY'S RESEARCH FOUNDATION & REDDY-CHEMINOR, INC.
Abstract: Compounds and pharmaceutical compositions useful as anti-parasitic agents agents, particularly in the treatment, prevention or amelioration of one or more symptoms of malaria or Chagas' disease, are provided. In particular, methods of modulating the activity of falcipain or cruzain, preferably inhibiting falcipain or cruzain, with the compounds and compositions are provided.
Type:
Application
Filed:
December 11, 2001
Publication date:
August 8, 2002
Inventors:
Marguerita Lim-Wilby, Joseph Edward Semple, Michael I. Weinhouse, Erick A. Goldman, Gian L. Araldi