The Additional Hetero Ring Contains Sulfur As The Only Ring Hetero Atom [e.g., 5-(2-thienyl) Hydantoin, Etc.] Patents (Class 548/315.1)
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Patent number: 6943183Abstract: The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis.Type: GrantFiled: April 16, 2001Date of Patent: September 13, 2005Assignee: Pfizer IncInventors: William Alexander Denny, Richard H. Hutchings, Douglas S. Johnson, James Stanley Kaltenbronn, Ho Huat Lee, Daniele Marie Leonard, Jared Bruce John Milbank, Joseph Thomas Repine, Gordon William Rewcastle, Andrew David White
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Patent number: 6916813Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts thereof, are useful for modulating mitochondrial F1F0 ATPase activity and treating ischemic conditions including myocardial infarction, congestive heart failure, and cardiac arrhythmias.Type: GrantFiled: December 10, 2002Date of Patent: July 12, 2005Assignee: Bristol-Myers Squibb Co.Inventors: Karnail S. Atwal, Gary J. Grover, Charles Z. Ding, Philip D. Stein, John Lloyd, Saleem Ahmad, Lawrnce G. Hamann, David Green, Francis N. Ferrara
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Patent number: 6890942Abstract: The present invention relates a series of compounds of Formula I wherein R1, R2, R3, and B are as defined in the specification. The compounds are useful for the inhibition of HIV integrase and for the treatment of AIDS or ARC by administering compounds of the formula.Type: GrantFiled: May 5, 2004Date of Patent: May 10, 2005Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Walker, Hatice Belgin Gulgeze, Jacques Banville, Roger Remillard, Donald Corson
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Patent number: 6875894Abstract: The invention relates to bis(alkylthio)carbenium salts of the formula I with the stated definitions for R1, R2, R3 and Y?, and to a process for the preparation thereof. The compounds according to the invention are advantageously suitable as electrophilic reagents for the transfer of fluorinated alkyl and acyl radicals onto nucleophilic compounds.Type: GrantFiled: February 11, 2002Date of Patent: April 5, 2005Assignee: Merck Patent GmbHInventors: Peer Kirsch, Andreas Ruhl, Gerd-Volker Röschenthaler, Dmitrii Sevenard
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Patent number: 6875788Abstract: Compounds of formula (I): wherein: R1 represents an optionally substituted heteroaryl group, R2 represents an optionally substituted cycloalkyl group, R3 represents a hydrogen atom or an alkyl group, and R4 and R5 are as defined in the description, and Medicinal products containing the same are useful in the treatment of non-insulin-dependent type II diabetes, obesity, type I diabetes, hyperlipidaemia, hypercholesterolaemia and cardiovascular complications thereof.Type: GrantFiled: October 20, 2003Date of Patent: April 5, 2005Assignee: Les Laboratoires ServierInventors: Sylvain Rault, Marina Kopp, Jean-Charles Lancelot, Stéphane Lemaitre, Daniel-Henri Caignard, Jean-Guy Bizot-Espiard, Pierre Renard
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Patent number: 6858611Abstract: Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.Type: GrantFiled: March 19, 2003Date of Patent: February 22, 2005Assignee: Icagen, Inc.Inventors: Aimee Dolores Reed, Michael Francis Gross, Serge Beaudoin
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Publication number: 20040242573Abstract: The invention relates to thiophene carboxanmides of formula (I). wherein A, R1, R2, R3, n and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.Type: ApplicationFiled: January 22, 2004Publication date: December 2, 2004Inventors: Alan Faull, Craig Johnstone, Andrew Morley, Jeffrey Philip Poyser
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Publication number: 20040171001Abstract: Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they do not require any chemical reaction on the probes or on the analytes since they are based on different electrostatic interactions between cationic poly (3-alkoxy-4-methylthiophene) derivatives and single-stranded or double-stranded (hibridized) oligonucleotides.Type: ApplicationFiled: April 5, 2004Publication date: September 2, 2004Inventors: Mario Leclerc, Hoang Ahn Ho, Maurice Boissinot
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Patent number: 6784173Abstract: Compounds of formula I wherein A, R1 and R2 are defined in the specification. These compounds are useful as HDAC inhibitors. Also disclosed are methods of making and using said compounds.Type: GrantFiled: June 11, 2002Date of Patent: August 31, 2004Assignee: Hoffmann-La Roche Inc.Inventors: Ulrike Leser-Reiff, Tim Sattelkau, Gerd Zimmermann
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Patent number: 6784298Abstract: Hydantoin compounds which are active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.Type: GrantFiled: June 4, 2003Date of Patent: August 31, 2004Assignee: Hoffmann-La Roche Inc.Inventors: Robert Alan Goodnow, Jr., Kang Le
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Publication number: 20040162324Abstract: The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.Type: ApplicationFiled: February 13, 2004Publication date: August 19, 2004Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.Inventors: Ramon Merce-Vidal, Blas Andaluz-Mataro, Jordi Frigola-Constansa
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Publication number: 20040157883Abstract: The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.Type: ApplicationFiled: August 26, 2003Publication date: August 12, 2004Inventors: Chiung-Tong Chen, Wen-Tai Li, Der-Ren Hwang, Chu-Chung Lin
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Patent number: 6770667Abstract: The present invention is a compound and pharmaceutical composition comprising a compound of formula (I): wherein R1 is a 4-(lower) alkyl-imidazol-1-yl or a 4,5-di(lower) alkyl-imidazol-1-yl group, R2 is a hydrogen atom or a lower alkyl group, and R3 is a fluorenyl group. The compound of formula (I) includes pharmaceutically acceptable salts: The compound of formula (I) and salts thereof have 5-HT antagonism activity.Type: GrantFiled: March 21, 2002Date of Patent: August 3, 2004Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyotaka Ito, Glen W. Spears, Fumie Takahashi, Akira Yamada, Masaki Tomishima, Hiroshi Miyake
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Publication number: 20040147575Abstract: Nitric acid salts with medicines having an antihypertensive activity.Type: ApplicationFiled: September 29, 2003Publication date: July 29, 2004Applicant: Nicox S.A.Inventor: Piero Del Soldato
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Publication number: 20040122053Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1Type: ApplicationFiled: December 9, 2003Publication date: June 24, 2004Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
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Publication number: 20040122004Abstract: The present invention relates to substituted phenylcyclohexanecarboxamides of the Formula (I) 1Type: ApplicationFiled: November 17, 2003Publication date: June 24, 2004Applicant: Bayer AktiengesellschaftInventors: Erwin Bischoff, Thomas Krahn, Stephan-Nicholas Muller, Holger Paulsen, Joachim Schuhmacher, Henning Steinhagen, Wolfgang Thielemann
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Publication number: 20040122024Abstract: An N-aminoimidazole or N-aminoimidazolethione derivative, a pharmaceutically acceptable salt, a tautomer, an isomer, an ester or glycosylation product thereof, said derivative being represented by general formula (I): wherein m=zero or 1, n=zero or 1, R1 is selected from hydrogen, methyl or ethyl, R2 is selected from hydrogen, SH or —SR0 wherein R0 is methyl, benzyl or glucose residue; Q is selected from 1-naphtyl, 2-naphtyl, biphenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, thienyl, or a substituted or unsubstituted phenyl ring, wherein the substitution is understood as being one or two substituents selected from H, F, Cl, Br, I, methyl, ethyl or isopropyl; L is selected from 1-naphtyl, 2-naphtyl, biphenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, thienyl, or a substituted or unsubstituted phenyl ring wherein the substitution is understood as being one or two substituents selected from H, F, Cl, Br, I, methyl, ethyl or isopropType: ApplicationFiled: February 11, 2004Publication date: June 24, 2004Inventors: Erik De Clercq, Arthur Van Aerschot, Piet Herdewijn, Irene Lagoja, Christophe Pannecoucque
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Publication number: 20040097733Abstract: Compounds of the formula 1Type: ApplicationFiled: July 2, 2003Publication date: May 20, 2004Inventors: Richard L. Beard, Thong Vu, Diana F. Colon, Vidyasagar Vuligonda, Roshantha A. Chandraratna
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Patent number: 6723743Abstract: This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as antagonists or inverse agonists of complement C5a receptors, preferably human C5a receptors, Preferred compounds of the invention possess one or more, and preferably two or more, three or more, four or more, or all of the following properties in that they are; 1) multi-aryl in structure (having a plurality of un-fused or fused aryl groups), 2) heteroaryl in structure, 3) orally available in vivo (such that a sub-lethal or preferably a pharmaceutically acceptable oral dose can provide a detectable in vitro effect such as a reduction of C5a-induced neutropenia), 4) comprised of fewer than four, preferably fewer than three, or fewer than two, or no amide bonds, and 5) capable of inhibiting leukocyte chemotaxis at nanomolar concentrations and preferably atType: GrantFiled: September 28, 2000Date of Patent: April 20, 2004Assignee: Neurogen CorporationInventors: Andrew Thurkauf, Xiao-shu He, He Zhao, John Peterson, Xiaoyan Zhang, Robbin Brodbeck, James Krause, George Maynard, Alan Hutchison
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Publication number: 20040019084Abstract: The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration of antioxidants or entities trapping reactive oxygen species (ROS) and intervening in a more general manner in the redox status of thiol groups. The invention also concerns methods for preparing them, pharmaceutical compositions containing them and their use for therapeutic purposes, particularly their use as NO-synthase inhibitors and/or as agents acting more generally in the redox status of thiol groups.Type: ApplicationFiled: April 21, 2003Publication date: January 29, 2004Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (S.C.R.A.S)Inventors: Jeremiah Harnett, Michel Auguet, Pierre-Etienne Chabrier de Lassauhyere
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Patent number: 6683190Abstract: The invention concerns a novel method for preparing chiral amino acids of formula (I) characterised in that it consists in contracting a racemic hydantoin of formula (II) with an enantiomeric splitting agent.Type: GrantFiled: October 9, 2001Date of Patent: January 27, 2004Assignee: Bayer Cropscience S.A.Inventor: Isabelle Pelta
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Publication number: 20040006119Abstract: Substituted thiophenes, processes for their preparation, their use as medicament or diagnostic agent.Type: ApplicationFiled: May 30, 2003Publication date: January 8, 2004Applicant: Aventis Pharma Deutschland GmbHInventors: Hans-Jochen Lang, Uwe Heinelt, Armin Hofmeister, Klaus Wirth, Michael Gekle, Markus Bleich
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Patent number: 6673941Abstract: Compounds of formula (I) and formula (II) are disclosed which are useful in the treatment bacterial infections: wherein: R1 is C1-4alkyl, Ar or 2-thienyl or 3-thienyl; R2 is C1-4alkyl or Ar; and n is 0-3; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 9, 2003Date of Patent: January 6, 2004Assignee: Affinium Pharmaceuticals, Inc.Inventors: Dirk Heerding, Kenneth A. Newlander
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Publication number: 20030229076Abstract: Disclosed are compounds of the formula: 1Type: ApplicationFiled: September 16, 2002Publication date: December 11, 2003Inventors: Stanislaw Rachwal, Alan Hutchison, Kenneth Shaw, George D. Maynard, Xiao-Shu He, Robert DeSimone, Kevin Hodgetts
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Publication number: 20030229123Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1Type: ApplicationFiled: April 29, 2003Publication date: December 11, 2003Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
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Publication number: 20030225145Abstract: A peroxisome proliferator activated receptor regulator containing a compound of formula (I) 1Type: ApplicationFiled: May 2, 2003Publication date: December 4, 2003Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Hisao Tajima, Yoshisuke Nakayama, Daikichi Fukushima
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Patent number: 6649643Abstract: Imidazol-4-ylmethanols and their uses for preventing and treating primary tumors, metastasis and recurrence of tumors, various symptoms accompanying tumors, prostatic hypertrophy, virilism, hirsutism, male pattern alopecia, precocious puberty, endometriosis, uterine myoma, mastopathy and polycystic ovary syndrome are disclosed.Type: GrantFiled: April 12, 2002Date of Patent: November 18, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Akihiro Tasaka, Akio Ojida, Tomohiro Kaku, Masami Kusaka, Masuo Yamaoka
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Patent number: 6639076Abstract: This invention relates to novel compounds of formula I wherein A, B, D, E, G, J, L, X, V are as defined in the specification, and the compounds are useful in the modulation of endogenous growth hormone levels in a mammal.Type: GrantFiled: April 17, 2001Date of Patent: October 28, 2003Assignee: Eli Lilly and CompanyInventors: Kenneth Lee Hauser, Jeffrey Alan Dodge, Mark Louis Heiman, Scott Alan Jones, Charles Arthur Alt, Henry Uhlman Bryant, James Densmore Copp, William Harlan Gritton, Charles Willis Lugar, III, Brian Stephen Muehl, Alan David Palkowitz, Andrew Michael Ratz, Gary Anthony Rhodes, Roger Lewis Robey, Timothy Alan Shepherd, Kenneth Jeff Thrasher, William George Trankle
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Patent number: 6630498Abstract: This invention relates to (E)-&agr;-[2-n-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene-2-thiophenepropionic acid arginyl charge-neutralization-complex, a process for its production, compositions containing the compound and methods of using the compound to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.Type: GrantFiled: December 12, 2001Date of Patent: October 7, 2003Assignee: SmithKline Beecham CorporationInventors: Manga R Gudipati, John M Jushchyshyn, Nageswara R Palepu, Gopadi M Venkatesh
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Publication number: 20030183812Abstract: A nonlinear optical chromophore having the formula D-&pgr;-A, wherein &pgr; is a &pgr; bridge including a thiophene ring having oxygen atoms bonded directly to the 3 and 4 positions of the thiophene ring, D is a donor, and A is an acceptor.Type: ApplicationFiled: March 24, 2003Publication date: October 2, 2003Inventors: Diyun Huang, Baoquan Chen
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Publication number: 20030186947Abstract: Compounds having Formula 4 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.Type: ApplicationFiled: February 11, 2003Publication date: October 2, 2003Inventors: Jayasree Vasudevan, Alan T. Johnson, Liming Wang, Roshantha A. Chandraratna
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Patent number: 6620826Abstract: Novel N-phenyl imidazole derivatives, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.Type: GrantFiled: January 29, 2003Date of Patent: September 16, 2003Assignee: SmithKline Beecham CorporationInventors: John Duncan Elliott, Joseph Weinstock, Jia-Ning Xiang
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Publication number: 20030171595Abstract: The invention relates to novel thienylsulphonylamino(thio)carbonyl compounds of the formula (I), 1Type: ApplicationFiled: October 31, 2002Publication date: September 11, 2003Inventors: Klaus-Helmut Muller, Ernst Rudolf F. Gesing, Mark Wilhelm Drewes, Johannes Rudolf Jansen, Rolf Kirsten, Joachim Kluth, Klaus Konig
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Patent number: 6613789Abstract: A class of imidazolyl compounds is described for use in treating inflammation. Compounds of particular interest are defined by Formula V: and pharmaceutically-acceptable salts thereof.Type: GrantFiled: December 5, 2001Date of Patent: September 2, 2003Assignee: G. D. Searle & Co.Inventors: Ish K. Khanna, Richard M. Weier, Paul W. Collins, Yi Yu, Xiangdong Xu, Richard A. Partis, Francis J. Koszyk, Renee M. Huff
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Patent number: 6605637Abstract: The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration of antioxidants or entities trapping reactive oxygen species (ROS) and intervening in a more general manner in the redox status of thiol groups. The invention also concerns methods for preparing them, pharmaceutical compositions containing them and their use for therapeutic purposes, particularly their use as NO-synthase inhibitors and/or as agents acting more generally in the redox status of thiol groups.Type: GrantFiled: September 27, 2001Date of Patent: August 12, 2003Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Jeremiah Harnett, Michel Auguet, Pierre-Etienne Chabrier de Lassauniere
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Publication number: 20030149089Abstract: Compounds of formula (I) and formula (II) are disclosed which are useful in the treatment bacterial infections: 1Type: ApplicationFiled: January 9, 2003Publication date: August 7, 2003Applicant: SmithKline Beecham CorporationInventors: Dirk Heerding, Kenneth A. Newlander
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Publication number: 20030144292Abstract: The compounds have a structure according to the following Formula (I): 1Type: ApplicationFiled: September 18, 2002Publication date: July 31, 2003Inventors: Michael George Natchus, Stanislaw Pikul, Neil Gregory Almstead, Matthew John Laufersweiler, Biswanath De
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Publication number: 20030144290Abstract: Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives capable of modulating NPY5 receptor activity, are provided. Such compounds may be used to modulate NPY binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders (e.g., eating disorders such as obesity or bulimia, psychiatric disorders, diabetes and cardiovascular disorders such as hypertension) in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such compounds for detecting NPY5 receptors.Type: ApplicationFiled: October 21, 2002Publication date: July 31, 2003Applicant: NEUROGEN CORPORATIONInventors: Charles A. Blum, Harry L. Brielmann, Stephane De Lombaert, Xiaozhang Zheng
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Publication number: 20030130307Abstract: Compounds of formula (I) 1Type: ApplicationFiled: December 20, 2002Publication date: July 10, 2003Inventors: Bernard Joseph Banks, Nathan Anthony Logan Chubb
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Publication number: 20030107027Abstract: A nonlinear optical chromophore having the formula D-&pgr;-A, wherein &pgr; is a &pgr; bridge including a thiophene ring having oxygen atoms bonded directly to the 3 and 4 positions of the thiophene ring, D is a donor, and A is an acceptor.Type: ApplicationFiled: November 22, 2002Publication date: June 12, 2003Inventors: Diyun Huang, Baoquan Chen
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Patent number: 6566380Abstract: Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.Type: GrantFiled: July 24, 2001Date of Patent: May 20, 2003Assignee: ICAgen, Inc.Inventors: Aimee Dolores Reed, Michael Francis Gross, Serge Beaudoin
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Patent number: 6559172Abstract: Novel disubstituted imidazoles are disclosed which are useful in the treatment of bacterial infections, particularly through the inhibition of FAB I.Type: GrantFiled: November 14, 2001Date of Patent: May 6, 2003Assignee: SmithKline Beecham CorporationInventors: Dirk Heerding, Kenneth A. Newlander
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Publication number: 20030078239Abstract: The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.Type: ApplicationFiled: October 11, 2001Publication date: April 24, 2003Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Patent number: 6545163Abstract: A process is disclosed for the preparation of imidazole derivatives, in particular, 1-aryl-2-(1-imidazolyl) alkyl ethers and thioethers, and more particular for the preparation of tioconazole. The preferred process involves alpha bromination of thiophene in cyclohexane, coupling with an imidazole to form the crude product, and forming the bisulfate salt thereof. The reaction utilizes less hazardous chemicals than currently employed for the production of 1-aryl-2-(1-imidazolyl) alkyl ethers and thioethers, and may be run at room temperature.Type: GrantFiled: October 2, 1995Date of Patent: April 8, 2003Assignee: Napp TechnologiesInventors: Olan Stanley Fruchey, Brian David Burke, Huh-Sun Chiou, Michele L. Nichols
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Publication number: 20030055266Abstract: Disclosed herein are small molecule modulators of the G protein coupled receptor six, methods of making such compounds, and methods of using such compounds.Type: ApplicationFiled: May 6, 2002Publication date: March 20, 2003Inventors: Nigel R.A. Beeley, Dominic P. Behan, Derek T. Chalmers, Frederique Menzaghi, Sonja Strah-Pleynet
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Publication number: 20030036655Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1Type: ApplicationFiled: May 31, 2002Publication date: February 20, 2003Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
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Patent number: 6521655Abstract: This invention relates to a series of substituted imidazoles of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with overproduction of inflammatory cytokines.Type: GrantFiled: November 3, 2000Date of Patent: February 18, 2003Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Scott A. Beers, Elizabeth A. Malloy, Michael P. Wachter, Wei Wu
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Patent number: 6518257Abstract: To provide a composition having a steroid C17,20-lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: wherein R is a hydrogen atom or a protecting group, R1 is a lower alkyl group or a cyclic hydrocarbon group, R2 is an aromatic hydrocarbon group optionally having substituents or an aromatic heterocyclic group optionally having substituents, R3 is a hydrocarbon group optionally having substituents, a hydroxyl group optionally having substituents, a thiol group optionally having substituents, an amino group optionally having substituents, an acyl group or a halogen atom, and n is an integer of 0 to 4, and a salt thereof have a steroid C17,20-lyase inhibitory activity, and are useful as an agent for the pophylaxis or treatment of prostatism and tumors such as beast cancer and the like.Type: GrantFiled: April 18, 2002Date of Patent: February 11, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Akihiro Tasaka, Tomohiro Kaku, Masami Kusaka
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Publication number: 20030023098Abstract: Methods and compounds for the treatment of conditions including pain, particularly chronic pain, glaucoma or elevated intraocular pressure with reduced cardiovascular or sedative side effects. Also included are methods of making and using such compounds.Type: ApplicationFiled: March 21, 2001Publication date: January 30, 2003Applicant: ALLERGAN SALES, INC.Inventors: Ken Chow, Daniel W. Gil, James A. Burke, Dale A. Harcourt, Michael E. Garst, Larry A. Wheeler
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Publication number: 20030004354Abstract: The invention relates to novel thienylsulphonylamino(thio)carbonyl compounds of the formula (I), 1Type: ApplicationFiled: November 9, 2001Publication date: January 2, 2003Inventors: Klaus-Helmut Muller, Ernst Rudolf F. Gesing, Mark Wilhelm Drewes, Johannes Rudolf Jansen, Rolf Kirsten, Joachim kluth, Klaus Konig, Ulrich Philipp, Markus Dollinger