Abstract: The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
Type:
Grant
Filed:
March 4, 2002
Date of Patent:
December 5, 2006
Assignee:
Glaxo Group Limited
Inventors:
Diane Mary Coe, Michael John Monteith, Panayiotis Alexandrou Procopiou
Abstract: A subject-matter of the disclosure is a novel composition for the dyeing of human keratinous fibres, for example, the hair, comprising a monocationic monoazo dye of formula (I) W1-N?N—W2-NW3-W4-W5, the dyeing processes employing it, the use of the dyes of formula (I) as direct dyes and the novel compounds of formula (I).
Abstract: The invention concerns a novel dyeing composition for dyeing keratinous fibers, in particular human hair, comprising a cationic azo-dye of formula (I): W1—N?N—W2—W3, as well as the dyeing method using said composition and the novel compounds of formula (I).
Abstract: A dye-forming coupler of the formula (I). A silver halide photographic light-sensitive material that contains at least one dye-forming coupler of the formula (I). A method for producing an azomethine dye, which method comprises using a compound of the formula (I): wherein E is an aryl, heterocyclic, or —C(?O)W group, in which W is a nitrogen-containing heterocyclic group, Z is an aryl or heterocyclic group, and X and Y each independently are ?O, ?S or ?N—R, in which R is a substituent, with the proviso that when E is an aryl or heterocyclic group, X and Y each are ?O, and that when E is a —C(?O)W group, Z is a substituted aryl group.
Abstract: The invention concerns a dyeing composition for dyeing keratinous fibers, in particular human keratinous fibers and more particularly hair, comprising a dicationic diazo dye of formula W1—N?N—W2—N?N—W3 as well as the dyeing method using same and the novel compounds of formula (I).
Abstract: The invention concerns a novel dyeing composition for dyeing keratinous fibers, in particular human hair, comprising a cationic azo-dye of formula (I): W1—N?N—W2—W3, as well as the dyeing method using said composition and the novel compounds of formula (I).
Abstract: The invention concerns a novel dyeing composition for dyeing keratinous fibers, in particular human hair, comprising a cationic azo dye of formula (I): W1—N?N—W2—NW3W4, and the dyeing method using said composition and the novel compounds of formula (I).
Abstract: The invention concerns a novel dyeing composition for dyeing keratinous fibers, in particular human hair, comprising a dicationic diazo dye of formula (I): W1—W2—N?N—W3—L—W4—N?N—W5—W6, as well as the dyeing method using said composition and the novel compounds of formula (I).
Abstract: The invention concerns a novel dyeing composition for dyeing keratinous fibers, in particular human hair, comprising a cationic azo-dye of formula (I): W1-N?N-W2-W3, as well as the dyeing method using said composition and the novel compounds of formula (I).
Abstract: The invention concerns a novel method for preparing chiral amino acids of formula (I) characterised in that it consists in contracting a racemic hydantoin of formula (II) with an enantiomeric splitting agent.
Abstract: A process for preparing blocked derivatives of m- or p- isopropenyl-&agr;,&agr;-dimethylbenzyl isocyanates, comprising reacting a meta- or a para-isopropenyl-&agr;,&agr;-dimethylbenzyl carbamate ester with hydroxy functional blocking group, such as hydroxyethylene-ethyleneurea, hydroxyethylenepropylene urea, dialkylaminoethanol and dialkylamino propanol
Abstract: Disclosed is a 5-acylamino-2-arylazo, nitro, or nitroso-4-substituted-phenol having the structural formula I:
wherein:
R* is an arylazo, nitro, or nitroso group,
Y is a coupling-off group, and
R′ is a substituent group.
Also disclosed is a method of using the compound in a simplified process for making a photographic coupler.
Abstract: Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind specifically to the androgen receptor and find use in indications associated with the androgen receptor, such as cell hyperplasia dependent on androgens, hirsutism, acne and androgenetic alopecia.
Type:
Grant
Filed:
February 11, 2000
Date of Patent:
October 29, 2002
Assignee:
Biophysica, Inc.
Inventors:
Milos Sovak, Allen L. Seligson, James Gordon Douglas, III, Brian Campion, Jason W. Brown
Abstract: The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R1, R2, R3 and R4 are as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.
Type:
Grant
Filed:
March 30, 2000
Date of Patent:
May 7, 2002
Assignee:
LG Chemical Ltd.
Inventors:
Jin Ho Lee, Jong Sung Koh, Jong Hyun Kim, Hyun Il Lee, Won Hee Jung, Seong Gu Ro, You Seong Shin, Sang Woong Kim, Ki Won Park, Tae Hwan Kwak, Kyung Duk Moon, Hyun Ho Chung
Abstract: A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules.
Type:
Grant
Filed:
August 16, 1999
Date of Patent:
March 12, 2002
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
Inventors:
Terence A. Kelly, Barbara Jean Bormann, Leah Lynn Frye, Jiang-Ping Wu
Abstract: Process for preparing compounds of the formula I
in which R is alkyl or aryl, in each case unsubstituted or substituted, R3 is hydrogen, alkyl or aryl, in each case unsubstituted or substituted, and X═O or NH,
which comprises reacting an aldehyde R—CHO with CO and a compound of the formula II
in which R2 is a group which reacts with a —CO2H group, which is formed during the reaction, with ring-closure to give compounds of the formula I,
in the presence of a transition metal catalyst described.
Type:
Grant
Filed:
April 27, 2000
Date of Patent:
November 20, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Michael Slany, Michael Schulz, Martin Schäfer, Edgar Zeller, Klaus Ebel
Abstract: Peptoid compounds of Formula I and Formula II are disclosed
The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.
Type:
Grant
Filed:
June 4, 1999
Date of Patent:
September 25, 2001
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Donald T. Witiak, Paul J. Bertics, Yingsheng Zhang
Abstract: A subject of the invention is the products of formula (I):
in which:
R1 and R2 represent in particular cyano and trifluoromethyl,
R3 represents in particular alkyl, alkenyl or alkynyl, substituted in particular by nitrooxy or carbonyloxy,
R4 and R5 represent in particular methyl optionally substituted by fluorine,
X and Y represent in particular oxygen, as well as their salts and isomers.
Type:
Grant
Filed:
September 28, 1998
Date of Patent:
June 5, 2001
Assignee:
Hoechst Marion Roussel
Inventors:
Andre Claussner, Francois Goubet, Jean-Georges Teutsch