Nitrogen Attached Directly To The Diazole Ring By Nonionic Bonding Patents (Class 548/321.5)
The nitrogen is attached directly to ring nitrogen of the diazole ring by nonionic bonding (e.g., dinitroethylene urea, etc.) (Class 548/322.1)
  • Benzoic acid derivatives, processes for producing the same and drugs containing the same as the active ingredient
    Publication number: 20030114435
    Abstract: An agent comprising the benzoic acid of formula (I) 1
    Type: Application
    Filed: August 16, 2002
    Publication date: June 19, 2003
    Inventors: Kousuke Tani, Kaoru Kobayashi, Takayuki Maruyama
  • Derivatives of C2-substituted indan-1-ol compounds, methods for their preparation and use
    Publication number: 20030105331
    Abstract: Derivatives of C2-substituted indan-1-ol compounds, processes for their preparation and their use are disclosed.
    Type: Application
    Filed: August 30, 2002
    Publication date: June 5, 2003
    Inventors: Gerhard Jaehne, Volker Krone, Martin Bickel, Matthias Gossel
  • Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
    Publication number: 20020132807
    Abstract: The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
    Type: Application
    Filed: June 25, 2001
    Publication date: September 19, 2002
    Inventors: Gary T. Wang, Sheldon Wang, Robert Gentles
  • Intermediates for (R)-3(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-a]imidazol-2-one
    Patent number: 6437148
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-a]imidazol-2-one (1): This compound is useful as an intermediate in the preparation of certain small molecules that are useful in the treatment or prevention of inflammatory and immune cell-mediated diseases. The present invention also relates to certain intermediates used in this novel process.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: August 20, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Phenylserine derivatives as integrin antagonists
    Publication number: 20020095050
    Abstract: The present invention relates to new phenylserine derivatives as integrin antagonists with a broad spectrum of action having, inter alia, antiosteoporotic, antirestenotic, anticarcinogenic and antiatherosclerotic activity. The present invention moreover relates to the preparation of these compounds and their use for the production of medicaments, and also medicaments comprising them.
    Type: Application
    Filed: June 12, 2001
    Publication date: July 18, 2002
    Inventor: Andrea Vaupel
  • INTERMEDIATES FOR (R)-3(4-BROMOBENZYL)-1-(3,5-DICHLOROPHENYL)-5-IODO-3-METHYL-1-H-IMIDAZO[1,2-A] IMIDAZOL-2-ONE
    Publication number: 20020087009
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1 ,2-a]imidazol-2-one (1): 1
    Type: Application
    Filed: February 15, 2002
    Publication date: July 4, 2002
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Tricyclic compounds, preparation method and said method intermediates, application as medicines and pharmaceutical compositions containing same
    Patent number: 6339082
    Abstract: A compound selected from the group consisting of a compound of the formula wherein the substituents are defined as set forth in the specification and its salts with non-toxic pharmaceutically acceptable acids and bases useful for treating loss of bone matrix.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: January 15, 2002
    Assignees: Aventis Pharma S.A., Genetech, Inc.
    Inventors: Denis Carniato, Thomas R. Gadek, Jean-Francois Gourvest, Jochen Knolle, Robert S. McDowell, Anurschirwan Peyman
  • Measurement and quantification of 17 ketosteroid-sulfates as a biomarker of biological age
    Patent number: 6326209
    Abstract: The present invention provides an improved method for using the measurement of total urinary 17 KS-S, referred to herein as the urinary Anabolic/Catabolic Index (ACI), as part of a biomarker for biological age.
    Type: Grant
    Filed: January 7, 2000
    Date of Patent: December 4, 2001
    Assignee: Univera Pharmaceuticals, Inc.
    Inventors: Qi Jia, Mei-Feng Hong, Stephen Cherniske
  • Hydrazono-benzazulene derivatives, pharmaceutical compositions and intermediates
    Patent number: 6277845
    Abstract: Compounds of the formula wherein the substituents are as defined in the application and their pharmaceutically acceptable acid and base salts thereof which are useful for preventing loss of bone matrix.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: August 21, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Denis Carniato, Thomas R. Gadek, Francois Goubet, Jean-Francois Gourvest, Jochen Knolle, Robert S. McDowell, Karl-Heinz Scheunemann
  • C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
    Patent number: 6197750
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: March 6, 2001
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Robert J. Ternansky