Nitrogen Attached Indirectly To The Diazole Ring By Acyclic Nonionic Bonding Patents (Class 548/324.5)
-
Patent number: 8946282Abstract: A novel class of indoline-2-one derivatives are disclosed. These compounds are protein kinase inhibitors which are useful for treating hyperproliferative diseases such as cancer.Type: GrantFiled: April 3, 2013Date of Patent: February 3, 2015Assignee: Annji Pharmaceutical Co., Ltd.Inventors: Ji-Wang Chern, Ajit Dhananjay Jagtap, Hsiao-Chun Wang, Grace Shiahuy Chen
-
Publication number: 20140315079Abstract: A method for preparing an imidazole compound with the following formula: wherein Rf is a fluorinated alkyl group comprising between 1 and 5 carbon atoms, said method including: (a) the reaction of the diaminomaleonitrile with the following formula: with the compound with the following formula: wherein Y represents a chlorine atom or the OCORf group to form the salified amide compound with the following formula: at temperature T1, and (b) the dehydration of the salified amide compound with formula (IVa) and/or the corresponding amino (IVb) to form the imidazole compound with formula (III), at temperature T2 higher than T1.Type: ApplicationFiled: October 29, 2012Publication date: October 23, 2014Inventors: Gregory Schmidt, Miguel Flasque
-
Patent number: 8828268Abstract: The present invention pertains to the field of thermosetting or thermoset polymers mainly used as materials, coatings or adhesives. The invention more specifically relates to the use of specific molecules having associative groups including a nitrogen heterocycle as a hardener or co-hardener of thermosetting polymers.Type: GrantFiled: June 3, 2013Date of Patent: September 9, 2014Assignee: Arkema FranceInventors: Bruno Van Hemelryck, Manuel Hidalgo
-
Patent number: 8822701Abstract: The present invention relates to a method for preparing 1-(2-aminoethyl)imidazolidin-2-one or the thiocarbonyl thereof, and also to the product that can be obtained according to this method, and which has a purity of at least 98%, and to the uses thereof.Type: GrantFiled: July 17, 2013Date of Patent: September 2, 2014Assignee: Arkema FranceInventors: Alain Baloche, Jean-Paul Gamet, Jean-Philippe Gillet
-
Patent number: 8637562Abstract: The invention relates to methods for detecting the presence of a compound of formula I in a biological test sample: where R2, R3, and R4 are as defined in the specification; or a salt thereof.Type: GrantFiled: December 17, 2012Date of Patent: January 28, 2014Assignee: Theravance, Inc.Inventors: Yuqin Dai, Donavon McConn, Huiyu Zhou
-
Publication number: 20130303784Abstract: The present invention relates to a method for preparing 1-(2-aminoethyl)imidazolidin-2-one or the thiocarbonyl thereof, and also to the product that can be obtained according to this method, and which has a purity of at least 98%, and to the uses thereof.Type: ApplicationFiled: July 17, 2013Publication date: November 14, 2013Inventors: Alain Baloche, Jean-Paul Gamet, Jean-Philippe Gillet
-
Patent number: 8530671Abstract: The present invention relates to a method of preparing a material formed from arborescent-branched molecules comprising associative groups that includes the following successive steps: (a) the reaction of at least one at least trifunctional compound (A) bearing first and second functional groups with at least one bifunctional compound (B), the functional groups of which are capable of reacting with the first functional groups of the compound (A); and (b) the reaction of the compound(s) obtained in step (a) with at least one compound (C) bearing, on the one hand, at least one reactive group capable of reacting with the second functional groups of (A) and, on the other hand, at least one given associative group.Type: GrantFiled: December 19, 2008Date of Patent: September 10, 2013Assignees: Arkema France, Centre National de la Recherche Scientifique CNRSInventors: François-Genes Tournilhac, Manuel Hidalgo, Ludwik Leibler
-
Patent number: 8513435Abstract: The present invention relates to a method for preparing 1-(2-aminoethyl)imidazolidin-2-one or the thiocarbonyl thereof, and also to the product that can be obtained according to this method, and which has a purity of at least 98%, and to the uses thereof.Type: GrantFiled: January 7, 2011Date of Patent: August 20, 2013Assignee: Arkema FranceInventors: Alain Baloche, Jean-Paul Gamet, Jean-Philippe Gillet
-
Patent number: 8372848Abstract: This invention relates generally to N-benzylamino cyclic thioureas, pharmaceutical compositions containing them, and their use as antagonists of melanin-concentrating hormone receptor (MCH receptor).Type: GrantFiled: March 23, 2005Date of Patent: February 12, 2013Assignees: Mixture Sciences, Inc., The Regents of the University of CaliforniaInventors: Richard A. Houghten, Colette Dooley, Adel Nefzi, Zhiwei Wang, Oliver Civelli, Hiroshi Nagasaki
-
Patent number: 8362061Abstract: The invention relates to methods for detecting the presence of a compound of formula I in a biological test sample: where R2, R3, and R4 are as defined in the specification; or a salt thereof.Type: GrantFiled: June 27, 2012Date of Patent: January 29, 2013Assignee: Theravance, Inc.Inventors: Yuqin Dai, Donavon McConn, Huiyu Zhou
-
Publication number: 20130023667Abstract: The present invention relates to a method for preparing 1-(2-aminoethyl)imidazolidin-2-one or the thiocarbonyl thereof, and also to the product that can be obtained according to this method, and which has a purity of at least 98%, and to the uses thereof.Type: ApplicationFiled: January 7, 2011Publication date: January 24, 2013Applicant: Arkema FranceInventors: Alain Baloche, Jean-Paul Gamet, Jean-Philippe Gillet
-
Publication number: 20120252699Abstract: The present invention relates to novel fluorophores and their use in combination with novel nucleic acid molecules, called aptamers, that bind specifically to the fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.Type: ApplicationFiled: February 18, 2010Publication date: October 4, 2012Applicant: CORNELL UNIVERSITYInventors: Samie R. Jaffrey, Jeremy S. Paige
-
Publication number: 20120209008Abstract: The invention provides processes for preparing intermediates useful for preparing compounds of the formula: or a salt thereof, where R1-3 are as defined in the specification.Type: ApplicationFiled: April 25, 2012Publication date: August 16, 2012Applicant: THERAVANCE, INC.Inventors: Weijiang Zhang, Pierre-Jean Colson
-
Patent number: 8232306Abstract: The invention relates to methods for detecting the presence of a compound of formula I in a biological test sample: where R2, R3, and R4 are as defined in the specification; or a salt thereof.Type: GrantFiled: October 15, 2009Date of Patent: July 31, 2012Assignee: Theravance, Inc.Inventors: Yuqin Dai, Donavon McConn, Huiyu Zhou
-
Patent number: 8202895Abstract: The present application relates to new, substituted 2-acetamido-5-aryl-1,2,4-triazolones, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.Type: GrantFiled: March 18, 2010Date of Patent: June 19, 2012Assignee: Bayer Pharma AktiengesellschaftInventors: Ulf Brüggemeier, Chantal Fürstner, Volker Geiβ, Joerg Keldenich, Armin Kern, Martina Delbeck, Peter Kolkhof, Axel Kretschmer, Elisabeth Pook, Carsten Schmeck, Hubert Trübel
-
Publication number: 20120074353Abstract: The present invention pertains to the field of thermosetting or thermoset polymers mainly used as materials, coatings, or adhesives. The invention more specifically relates to the use of specific molecules having associative groups including a nitrogen heterocycle as a hardener or co-hardener of thermosetting polymers.Type: ApplicationFiled: June 4, 2010Publication date: March 29, 2012Applicant: Arkema FranceInventors: Bruno Van Hemelryck, Manuel Hidalgo
-
Patent number: 7994204Abstract: The present invention aims to provide compounds which have an inhibitory effect on the binding between S1P and its receptor Edg-1(S1P1) and which are useful for pharmaceutical purposes. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: [wherein Ar represents a monocyclic heterocyclic ring containing one or two nitrogen atoms, A represents an oxygen atom or the like, Y1, Y2 and Y3 each represent a carbon atom or a nitrogen atom, R1 represents a hydrogen atom, a C1-C6 alkyl group or the like, R2 represents a C1-C6 alkyl group, a C3-C8 cycloalkyl group or the like, R3 represents a C1-C18 alkyl group or the like, R4 represents a hydrogen atom or a C1-C6 alkyl group, and R5 represents a C1-C10 alkyl group or the like].Type: GrantFiled: February 6, 2007Date of Patent: August 9, 2011Assignee: Taisho Pharmaceutical Co., LtdInventors: Naoya Ono, Tetsuo Takayama, Fumiyasu Shiozawa, Hironori Katakai, Tetsuya Yabuuchi, Tomomi Ota, Takeshi Koami, Rie Nishikawa
-
Publication number: 20100305334Abstract: The present invention relates to a method of preparing a material formed from arborescent-branched molecules comprising associative groups that includes the following successive steps: (a) the reaction of at least one at least trifunctional compound (A) bearing first and second functional groups with at least one bifunctional compound (B), the functional groups of which are capable of, reacting with the first functional groups of the compound (A); and (b) the reaction of the compound(s) obtained in step (a) with at least one compound (C) bearing, on the one hand, at least one reactive group capable of reacting with the second functional groups of (A) and; on the other hand, at least one given associative groupType: ApplicationFiled: December 19, 2008Publication date: December 2, 2010Applicant: Arkema FranceInventor: Francois-Genes Tournilhac
-
Publication number: 20100286219Abstract: A method comprising utilizing a compound of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl or alkylaryl group; X signifies CH2, oxygen atom or sulphur atom; n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2; and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof; wherein the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term aryl means a phenyl or naphthyl group, optionally substituted by alkyloxy, halogen or nitro group; the term halogen means fluorine, chlorine, bromine or iodine, in the manufacture of a medicament for the treatment of one or more of the following indications: congestive heart failure, anginaType: ApplicationFiled: January 10, 2008Publication date: November 11, 2010Applicant: BIAL - PORTELA & CA S.A.Inventor: Patricio Manuel Vieira Araújo Soares Da Silva
-
Publication number: 20090149425Abstract: The present invention provides a malononitrile compound represented by the formula (I): wherein any one of X1, X2, X3 and X4 is CR100, wherein R100 is a group represented by the formula: the other three of X1, X2, X3 and X4 each represent nitrogen or CR5, provided that 1 to 3 of X1, X2, X3 and X4 represent nitrogen, and Z represents oxygen, sulfur or NR6, which has pest-controlling activity.Type: ApplicationFiled: January 13, 2005Publication date: June 11, 2009Inventors: Hiromasa Mitsudera, Ken Otaka, Jun Fujiwara
-
Patent number: 7528200Abstract: An epoxy-hardener system is provided having relatively long latency periods combined with relatively short cure times at low cure temperatures. The hardeners of the present invention are ureidoamines and their derivatives, which are chelates of ureido compounds and amines. The ureidoamines are prepared by reacting an amine with the ureido compound and aqueous formaldehyde without a catalyst. Complexes of ureidoamine hardeners with various blocking agents are prepared in the melt. The hardener is prevented from curing the epoxy by the reaction between the hardener and the blocking agent. The blocked hardener is then blended with the epoxy, usually by warming the mixture briefly at about 50-60 degrees C.Type: GrantFiled: February 1, 2006Date of Patent: May 5, 2009Assignee: ARDES Enterprises, Inc.Inventor: Richard D. Schile
-
Patent number: 7488830Abstract: A polymer that includes at least one monomeric unit having a pendant substituent group according to formula (II): wherein: R1 is H, chloro, bromo, alkyl, hydroxyalkyl, aryl, or aralkyl, R2 and R3 are each independently H, alkyl, hydroxyalkyl, aryl, aralkyl, uriedo, or carboxyalkylene, R4 is alkylene or R5, R7, and R10 are each independently alkylene, R6, R8, and R9 are each independently H or alkyl, A is O or N—R11, provided if A is O and R4 is methylene, then R1 cannot be H, chloro, or bromo, R11 is H or alkyl, and X? is an anion, is useful in personal care application, such as hair styling compositions.Type: GrantFiled: July 26, 2006Date of Patent: February 10, 2009Assignee: Rhodia Inc.Inventors: Krishnamurthy Shanmuganandamurthy, Euen Gunn, Stewart Alexander Warburton
-
Patent number: 7439242Abstract: Modulators of PPAR? activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.Type: GrantFiled: April 15, 2002Date of Patent: October 21, 2008Assignee: Amgen Inc.Inventors: Jonathan B. Houze, Lawrence R. McGee, Steven Marc Rubenstein
-
Publication number: 20080255218Abstract: This invention relates generally to N-benzylamino cyclic thioureas, pharmaceutical compositions containing them, and their use as antagonists of melanin-concentrating hormone receptor (MCH receptor).Type: ApplicationFiled: March 23, 2005Publication date: October 16, 2008Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Richard A. Houghten, Colette Dooley, Adel Nefzi, Zhiwei Wang, Oliver Civelli, Hiroshi Nagasaki
-
Publication number: 20080221169Abstract: Compounds, including 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels and methods of using them to treat disorders or diseases mediated by aquaporins.Type: ApplicationFiled: October 26, 2007Publication date: September 11, 2008Applicant: ARIZONA BOARD OF REG. ON BEHALF OF THE UNIV. OF AZInventors: Gary A. Flynn, Andrea J. Yool, Elton Rodrigues Migliati, Leslie S. Ritter
-
Publication number: 20080176919Abstract: This invention relates to benzonitrile derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R3 are defined in the description, to their use in medicine, and to compositions containing them. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof.Type: ApplicationFiled: December 23, 2005Publication date: July 24, 2008Inventors: Lyn Howard Jones, Sandra Dora Newman, Nigel Alan Swain
-
Patent number: 7390829Abstract: A compound is disclosed herein comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein R is OH or NH2. Methods, compositions, and medicaments related thereto are also disclosed.Type: GrantFiled: June 29, 2005Date of Patent: June 24, 2008Assignee: Allergan, Inc.Inventors: Ken Chow, Todd M. Heidelbaugh, Phong X. Nguyen
-
Patent number: 7265135Abstract: The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compounds and methods of using them in the treatment of neurological disorders and other disorders and conditions mediated by the histamine H3 receptor.Type: GrantFiled: January 14, 2004Date of Patent: September 4, 2007Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Michael Bogenstaetter, Nicholas I. Carruthers, Jill A. Jablonowski, Timothy W. Lovenberg, Kiev S. Ly
-
Patent number: 7125904Abstract: Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl or alkylaryl group; X is CH2, O or S, and n is 1, 2 or 3, with the proviso that if X is CH2, n is not 1, and a method for their preparation. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.Type: GrantFiled: October 8, 2003Date of Patent: October 24, 2006Assignee: Portela & C.A., S.A.Inventors: David Alexander Learmonth, Patricio Manuel Viera Araújo Soares da Silva, Alexander Beliaev
-
Patent number: 7045532Abstract: ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I): Z-???(I) Wherein Z is a zinc coordinating moiety and ? is an amino-acid mimicking moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors and pharmaceutical compositions containing the inhibitors to treat a body weight disorder, to decrease appetite, to increase muscle mass, to decrease body fat, to treat diabetes and to treat a state associated with altered lipid metabolism, are also described.Type: GrantFiled: October 31, 2001Date of Patent: May 16, 2006Assignee: Millennium Pharmaceuticals, Inc.Inventors: Susan L. Acton, Timothy D. Ocain, Alexandra E. Gould, Natalie A. Dales, Bing Guan, James A. Brown, Michael Patane, Vivek J. Kadambi, Michael Solomon, Alain Stricker-Krongrad
-
Patent number: 6884815Abstract: This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as antagonists or inverse agonists of complement C5a receptors. Preferred compounds of the invention possess some or all of the following properties in that they are: 1) multi-aryl in structure, 2) heteroaryl in structure, 3) a pharmaceutically acceptable oral dose can provide a detectable in vitro effect, 4) comprise fewer than four or preferably no amide bonds, and 5) capable of inhibiting leukocyte chemotaxis at nanomolar or sub-nanomolar concentrations. This invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds in treating a variety of inflammatory and immune system disorders. Additionally, this invention relates to the use such compounds as probes for the localization of C5a receptors.Type: GrantFiled: June 12, 2003Date of Patent: April 26, 2005Assignee: Neurogen CorporationInventors: Andrew Thurkauf, Xiao-shu He, He Zhao, John Peterson, Xiaoyan Zhang, Robbin Brodbeck, James Krause, George Maynard, Alan Hutchison
-
Patent number: 6627758Abstract: Compositions and methods are described for hydrating terminal alkynes catalytically in anti-Markovnikov fashion. The compositions comprise a transition metal complex including at least one organic ligand having at least two heteroatoms, wherein the heteroatoms are directly bonded or located one atom away. Preferably, at least one of the heteroatoms is nitrogen, which is typically provided as part of a heterocyclic ring. Other preferred heteroatoms include S, P, N, As or Se. A particularly preferred catalyst employs a P-linked imidazole ligand bound to Ru. Such complexes have a controlled adaptable proton transfer ability and/or a hydrogen bonding ability making them particularly useful as chemical reaction facilitators.Type: GrantFiled: February 16, 2001Date of Patent: September 30, 2003Assignee: San Diego State University FoundationInventor: Douglas Bryan Grotjahn
-
Patent number: 6362183Abstract: An aromatic sulfonyl alpha-hydroxy hydroxamic acid compound that, inter alia, inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.Type: GrantFiled: June 4, 1999Date of Patent: March 26, 2002Assignee: G. D. Searle & CompanyInventors: John N. Freskos, Terri L. Boehm, Brent V. Mischke, Robert M. Heintz, Joseph J. McDonald, Gary A. DeCrescenzo, Susan C. Howard
-
Patent number: 6288151Abstract: Novel alkyl aminoalkyl cyclic urea compounds of the structural formula: wherein each of m, n, and o are independently 1 or 2, p is 0 or 1, R1 is C1 to C4 linear or branched alkyl, R2 is C4 to C10 linear or branched alkyl, or, alternately, CHR1R2 forms a C6 to C12 substituted or unsubstituted cycloalkyl. These novel alkylated aminoalkyl cyclic ureas are useful as surfactants for reducing equilibrium and dynamic surface tension in water-based formulations, particularly coating, ink, and agricultural formulations.Type: GrantFiled: October 14, 1999Date of Patent: September 11, 2001Assignee: Air Products and Chemicals, Inc.Inventors: Kevin Rodney Lassila, Kristen Elaine Minnich, Richard Van Court Carr
-
Patent number: 6229011Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.Type: GrantFiled: August 21, 1998Date of Patent: May 8, 2001Assignee: Hoffman-La Roche Inc.Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achyutharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull